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Han-Mo Chiu

Murdani Abdullah, Ajay Kumar, Han-Mo Chiu, Khean-Lee Goh, Byung Ik Jang, Christopher J L Khor, James Lau, Ibrahim Mostafa, Mohan Ramchandani, Siriporn Ratanalert, Hisao Tajiri, Minghwa Yuen, Shu Tian Zhang, Danielle Duforest-Rey, Jean-François Rey
In many endoscopy units in Asia and the Middle East, reprocessing procedures have lagged behind those of Western countries for cultural reasons or lack of financial resources. This inconsistency in standards is now being addressed, and the World Endoscopy Organization (WEO) have prepared this position statement to highlight the key points for quality assurance in any endoscopy unit in any country. This article is protected by copyright. All rights reserved.
October 1, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Chu-Kuang Chou, Chi-Yang Chang, Chun-Chao Chang, Li-Chun Chang, Wen-Feng Hsu, Chi-Yi Chen, Hsiu-Po Wang, Han-Mo Chiu
BACKGROUND: Bowel preparation is burdensome, and less-demanding preparation procedures are needed. Few studies have investigated the effects of low-residue diet and prepackaged low-residue diet in combination with low-volume polyethylene glycol-electrolyte lavage solution during colonoscopy preparation. OBJECTIVE: We compared self-prepared low-residue diets with prepackaged low-residue diets in combination with low-volume polyethylene glycol. DESIGN: This was a single-blinded, 3-arm, multicenter, randomized controlled trial...
October 2016: Diseases of the Colon and Rectum
Li-Chun Chang, Chia-Tung Shun, Weng-Feng Hsu, Chia-Hong Tu, Pei-Yu Tsai, Been-Ren Lin, Jin-Tung Liang, Ming-Shiang Wu, Han-Mo Chiu
BACKGROUND & AIMS: The serrated pathway is a distinct pathway of colorectal carcinogenesis that has been implicated in development of a substantial proportion of interval colorectal cancers. The fecal immunochemical test (FIT) detects early neoplasms with a higher level of sensitivity than the guaiac test. We investigated the sensitivity of the FIT in detection of sessile serrated adenomas/polyps (SSA/Ps). METHODS: We performed a prospective study of 6198 asymptomatic subjects (mean age, 59...
August 4, 2016: Clinical Gastroenterology and Hepatology
Takahisa Matsuda, Masau Sekiguchi, Yasuo Kakugawa, Hiroaki Ikematsu, Yasuhiro Oono, Han-Mo Chiu, Yasushi Sano, Takahiro Fujii, Yutaka Saito
No abstract text is available yet for this article.
July 2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Chu-Kuang Chou, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Sherry Yueh-Hsia Chiu, Jean Ching-Yuan Fann, Han-Mo Chiu, Shu-Lin Chuang, Tsung-Hsien Chiang, Ming-Shiang Wu, Chien-Yuan Wu, Shu-Li Chia, Yi-Chia Lee, Shu-Ti Chiou, Hsiu-Hsi Chen
BACKGROUND: Outreach (i.e., to invite those who do not use, or who under use screening services) and inreach (i.e., to invite an existing population who have already accessed the medical system) approaches may influence people to increase their use of screening test; however, whether their outcomes would be equivalent remains unclear. METHODS: A total of 3,363,896 subjects, 50-69 years of age, participated in a colorectal cancer (CRC) screening program using biennial fecal immunochemical tests; 34...
2016: PloS One
Amy Ming-Fang Yen, Huei-Shian Tsau, Jean Ching-Yuan Fann, Sam Li-Sheng Chen, Sherry Yueh-Hsia Chiu, Yi-Chia Lee, Shin-Liang Pan, Han-Mo Chiu, Wen-Horng Kuo, King-Jen Chang, Yi-Ying Wu, Shu-Lin Chuang, Chen-Yang Hsu, Dun-Cheng Chang, Shing-Lang Koong, Chien-Yuan Wu, Shu-Lih Chia, Mei-Ju Chen, Hsiu-Hsi Chen, Shu-Ti Chiou
IMPORTANCE: Different screening strategies for breast cancer are available but have not been researched in quantitative detail. OBJECTIVE: To assess the benefits and the harms of risk-based and universal mammography screening in comparison with annual clinical breast examination (CBE). DESIGN: Population-based cohort study comparing incidences of stage II+ disease and death from breast cancer across 3 breast cancer screening strategies, with adjustment for a propensity score for participation based on risk factors for breast cancer and comparing the 3 strategies for overdetection between January 1999 and December 2009...
July 1, 2016: JAMA Oncology
Martin C S Wong, Jessica Y L Ching, Han-Mo Chiu, Kai Chun Wu, Rungsun Rerknimitr, Jingnan Li, Deng-Chiang Wu, Khean Lee Goh, Takahisa Matsuda, Hyun-Soo Kim, Rupert Leong, Khay Guan Yeoh, Vui Heng Chong, Jose D Sollano, Furqaan Ahmed, Jayaram Menon, Siew C Ng, Justin C Y Wu, Francis K L Chan, Joseph J Y Sung
OBJECTIVES: We tested the hypothesis that the risk of colorectal cancer (CRC), advanced colorectal neoplasia (ACN), and colorectal adenoma among screening participants with different first-degree relatives (FDRs) affected by CRC was similar. METHODS: A multi-center, prospective colonoscopy study involving 16 Asia-Pacific regions was performed from 2008 to 2015. Consecutive self-referred CRC screening participants aged 40-70 years were recruited, and each subject received one direct optical colonoscopy...
March 15, 2016: American Journal of Gastroenterology
Yu-Ting Huang, Yu-Wei Lin, Han-Mo Chiu, Been-Huang Chiang
This study investigated the effect of curcumin on colorectal cancer stem cells (CCSCs) and its possible mechanism. Comparison of the metabolic profiles of human adenomatous polyp (N = 61) and colorectal cancer (CRC) (N = 57) tissue found statistically significant differences (p < 0.05) in their composition of adenosine monophosphate (AMP), adenine, 5'-methythioadenosine, 3-hydroxybutyric acid, prostaglandin E2, threonine, and glutamine. Our cell culture model study found that curcumin treatment (50 μM for 48 h) did indeed increase apoptosis of CRC cells as well as of CCSCs, but at a significant level only in CD44(+) cells...
March 23, 2016: Journal of Agricultural and Food Chemistry
Takahisa Matsuda, Han-Mo Chiu, Yasushi Sano, Takahiro Fujii, Akiko Ono, Yutaka Saito
Colonoscopy is considered the gold standard to detect and remove colorectal neoplasia. The efficacy of colonoscopy with polypectomy to reduce colorectal cancer incidence and mortality has been demonstrated. Recently, post-polypectomy surveillance colonoscopy has become a necessary intervention in daily practice not only in Western countries but also in the Asia-Pacific region. Therefore, it is crucial to establish new clinical practice guidelines to reduce the number of unnecessary surveillance colonoscopies in order to create space for screening colonoscopy...
April 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Han-Mo Chiu, Li-Chun Chang, Wen-Feng Hsu, Chu-Kuang Chou, Ming-Shiang Wu
There is an increasing trend of colorectal cancer incidence in Asia and nearly 45% of CRC cases worldwide occur in Asia therefore screening for CRC becomes an urgent task. Stool-based tests, including guaiac fecal occult blood test (gFOBT) and fecal immunochemical test (FIT), can select subjects at risk of significant colorectal neoplasms from the large target population thus are currently the most commonly used non-invasive screening tool in large population screening programs. FIT has the advantage over gFOBT in terms of higher sensitivity for early neoplasms, the ability to provide high-throughput automatic analysis, and better public acceptance thus greater effectiveness on reducing CRC mortality and incidence is expected...
December 2015: Best Practice & Research. Clinical Gastroenterology
Han-Mo Chiu, Jessica Y L Ching, Kai Chun Wu, Rungsun Rerknimitr, Jingnan Li, Deng-Chiang Wu, Khean Lee Goh, Takahisa Matsuda, Hyun-Soo Kim, Rupert Leong, Khay Guan Yeoh, Vui Heng Chong, Jose D Sollano, Furqaan Ahmed, Jayaram Menon, Joseph J Y Sung
BACKGROUND & AIMS: Age, sex, smoking, and family history are risk factors for colorectal cancer in Asia. The Asia-Pacific Colorectal Screening (APCS) scoring system was developed to identify subjects with a high risk for advanced neoplasm (AN). We tested an algorithm that combined APCS scores with fecal immunochemical test (FIT) in colorectal cancer screening. METHODS: We performed a multicenter prospective study, enrolling asymptomatic individuals older than 40 years old in 12 Asia-Pacific regions from December 2011 to December 2013...
March 2016: Gastroenterology
Yasushi Sano, Jeong-Sik Byeon, Xiao-Bo Li, Martin C S Wong, Han-Mo Chiu, Rungsun Rerknimitr, Takahiro Utsumi, Santa Hattori, Wataru Sano, Mineo Iwatate, Philip Chiu, Joseph Sung
In recent years, the incidence of colorectal cancer (CRC) has been increasing, and CRC has been becoming the major cause of cancer deaths in Asian countries. Therefore, an organized screening program to reduce CRC incidence and mortality is currently implemented in each country. In the present review, we summarize the current status and future perspectives of CRC screening of the general population in East Asian and South-East Asian countries. The fecal occult blood test is widely used for CRC screening in these countries, and its effectiveness in reducing CRC incidence and mortality has been demonstrated; however, the low participation rate in CRC screening programs is a problem to be solved in every country...
April 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Sherry Yueh-Hsia Chiu, Shu-Ling Chuang, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Jean Ching-Yuan Fann, Dun-Cheng Chang, Yi-Chia Lee, Ming-Shiang Wu, Chu-Kuang Chou, Wen-Feng Hsu, Shu-Ti Chiou, Han-Mo Chiu
OBJECTIVES: Interval colorectal cancer (CRC) after colonoscopy may affect effectiveness and cost-effectiveness of screening programmes. We aimed to investigate whether and how faecal haemoglobin concentration (FHbC) of faecal immunochemical testing (FIT) affected the risk prediction of interval cancer (IC) caused by inadequate colonoscopy quality in a FIT-based population screening programme. DESIGN: From 2004 to 2009, 29 969 subjects underwent complete colonoscopy after positive FIT in the Taiwanese Nationwide CRC Screening Program...
October 29, 2015: Gut
Tsung-Hsien Chiang, Yi-Chia Lee, Wan-Chung Liao, Jui-Hung Chung, Han-Mo Chiu, Chia-Hung Tu, Su-Chiu Chen, Ming-Shiang Wu
BACKGROUND: Following a negative test, the performance of fecal immunochemical testing in the subsequent screening round is rarely reported. It is crucial to allocate resources to participants who are more likely to test positive subsequently following an initial negative result. OBJECTIVE: To identify risk factors associated with a positive result in subsequent screening. METHODS: Dataset was composed of consecutive participants who voluntarily underwent fecal tests and colonoscopy in a routine medical examination at the National Taiwan University Hospital between January 2007 and December 2011...
2015: PloS One
Mei-Jyh Chen, Yu-Tse Tsan, Jyh-Ming Liou, Yi-Chia Lee, Ming-Shiang Wu, Han-Mo Chiu, Hsiu-Po Wang, Pau-Chung Chen
The aim of this study was to determine whether statin use exerts a protective effect against pancreatic cancer in Type 2 diabetic patients. A retrospective population-based cohort study was designed to analyze the National Health Insurance Research database (NHIRD) from 1997-2010 in Taiwan. A total of 1,140,617 patients with a first-time diagnosis of Type 2 diabetes were enrolled. The event was defined as newly diagnosed pancreatic cancer. A Cox proportional hazards regression model with time-dependent covariates was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of pancreatic cancer associated with statin use in the diabetic cohort...
February 1, 2016: International Journal of Cancer. Journal International du Cancer
Chi-Sheng Hung, Ping-Huei Tseng, Chia-Hung Tu, Chien-Chuan Chen, Wei-Chih Liao, Yi-Chia Lee, Han-Mo Chiu, Hung-Ju Lin, Yi-Lwun Ho, Wei-Shiung Yang, Ming-Shiang Wu, Ming-Fong Chen
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is independently associated with QT prolongation among patients with diabetes. It has not yet been determined whether this association remains valid in the general population. We designed an observational study to explore this association. METHODS AND RESULTS: We conducted a cross-sectional analysis of 31 116 consecutive participants in our health management program. Heart rate-corrected QT (QTc) interval was derived from 12-lead electrocardiography and by Bazett's formula...
July 2015: Journal of the American Heart Association
Han-Mo Chiu, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Sherry Yueh-Hsia Chiu, Jean Ching-Yuan Fann, Yi-Chia Lee, Shin-Liang Pan, Ming-Shiang Wu, Chao-Sheng Liao, Hsiu-Hsi Chen, Shin-Lan Koong, Shu-Ti Chiou
BACKGROUND: The effectiveness of fecal immunochemical testing (FIT) in reducing colorectal cancer (CRC) mortality has not yet been fully assessed in a large, population-based service screening program. METHODS: A prospective cohort study of the follow-up of approximately 5 million Taiwanese from 2004 to 2009 was conducted to compare CRC mortality for an exposed (screened) group and an unexposed (unscreened) group in a population-based CRC screening service targeting community residents of Taiwan who were 50 to 69 years old...
September 15, 2015: Cancer
Yan Zhang, Yong-Fei Wang, Jing Yang, Jing Zhang, Liangdan Sun, Nattiya Hirankarn, Hai-Feng Pan, Chak Sing Lau, Tak Mao Chan, Tsz Leung Lee, Alexander Moon Ho Leung, Chi Chiu Mok, Lu Zhang, Jiangshan Jane Shen, Sik Nin Wong, Ka Wing Lee, Marco Hok Kung Ho, Pamela Pui Wah Lee, Brian Hon-Yin Chung, Chun Yin Chong, Raymond Woon Sing Wong, Mo Yin Mok, Wilfred Hing Sang Wong, Kwok Lung Tong, Niko Kei Chiu Tse, Xiang-Pei Li, Yingyos Avihingsanon, Pornpimol Rianthavorn, Thavatchai Deekajorndej, Kanya Suphapeetiporn, Vorasuk Shotelersuk, Shirley King Yee Ying, Samuel Ka Shun Fung, Wai Ming Lai, Chun-Ming Wong, Irene Oi Lin Ng, Maria-Merce Garcia-Barcelo, Stacey S Cherny, Paul Kwong-Hang Tam, Pak Chung Sham, Sen Yang, Dong Qing Ye, Yong Cui, Xue-Jun Zhang, Wanling Yang, Yu Lung Lau
INTRODUCTION: Systemic lupus erythematosus (SLE) is a heterogeneous disease with a diverse spectrum of clinical symptoms, ranging from skin rash to end-organ damage. 22q11.21 has been identified as a susceptibility region for several autoimmune diseases, including SLE. However, detailed information for SLE association and the underlying functional mechanism(s) is still lacking. METHODS: Through meta-analysis of two genome-wide association studies (GWAS) on Han Chinese populations, comprising a total of 1,659 cases and 3,398 controls matched geographically, we closely examined the 22q11...
2015: Arthritis Research & Therapy
Takahisa Matsuda, Hiroshi Kawano, Han-Mo Chiu
Colonoscopy is considered the best modality for the detection and treatment of colorectal polyps. However, some polyps still may not be detected. Although conventional white-light endoscopy is the gold standard for the detection of colorectal polyps, up to a fifth of lesions may be missed on screening colonoscopy, especially non-polypoid colorectal neoplasms. Recently, many studies have reported on various endoscopic modalities that improve the detection and characterization of colorectal lesions. Newly developed modalities might be helpful to recognize colorectal lesions; however, careful observation is required to identify flat/depressed lesions as well as hidden polyps during screening and surveillance colonoscopy...
April 2015: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Li-Chun Chang, Han-Mo Chiu, Chia-Tung Shun, Jin-Tung Liang, Jaw-Town Lin, Chien-Chuan Chen, Yi-Chia Lee, Ming-Shiang Wu
BACKGROUND: Investigations of genetic alterations and correlations with histology or morphology could provide further insights into colorectal carcinogenesis. Nevertheless, such genetic changes were less investigated in adenoma stage and a comprehensive survey of oncogenic mutations in EGFR signaling pathway according to different morphologic subtypes has not been performed. METHODS: A total of 94 neoplasms, including 34 polypoid adenoma, 16 lateral spreading tumors-granular (LST-G), 20 non-granular LST (LST-NG), and 24 depressed tumors, were subjected for mutational analysis of KRAS (exon 2), BRAF (exon 11 and 15), PIK3CA (exon 9 and 20), AKT (exon 4), EGFR (exon 18-24) and HER2 (exon18-24)...
2014: BMC Gastroenterology
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