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Han-Mo Chiu

Ying-Wei Wang, Hsiu-Hsi Chen, Ming-Shiang Wu, Han-Mo Chiu
Colorectal cancer (CRC) is the most common cancer in Taiwan, and is the third leading cause of cancer-related death. Screening has been proven the most effective way to reduce CRC mortality, and stool-based screening is currently the most popular method of screening worldwide. In 2004, Taiwanese government launched a nationwide screening program and fecal immunochemical test (FIT) is offered biennially to individuals aged 50 to 75. The results from the program have demonstrated that FIT screening could effectively reduce the mortality from CRC...
October 5, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Han-Mo Chiu, Wen-Feng Hsu, Li-Chun Chang, Ming-Hsiang Wu
PURPOSE OF REVIEW: Colorectal cancer (CRC) is increasing in Asia, especially in regions with higher levels of economic development. Several Asian countries have launched population CRC screening programs to combat this devastating disease because previous studies have demonstrated that either fecal occult blood test or lower gastrointestinal endoscopy can effectively reduce CRC mortality. RECENT FINDINGS: Screening includes engaging the population, testing, administering a confirmation examination, and treating screening-detected neoplasms; thus, monitoring the whole process using measurable indicators over time is of utmost importance...
August 10, 2017: Current Gastroenterology Reports
Li-Chun Chang, Chia-Hung Tu, Been-Ren Lin, Chia-Tung Shun, Weng-Feng Hsu, Jin-Tung Liang, Hsiu-Po Wang, Ming-Shiang Wu, Han-Mo Chiu
BACKGROUND AND AIMS: Endoscopic diagnosis of sessile serrated adenomas/polyps (SSA/P) is challenging because of their subtle appearance. Narrow-band imaging (NBI) is useful for diagnosis, but its utility with concurrent chromoendoscopy (CE), especially to detect small SSA/P, is unproven. PATIENTS AND METHODS: This prospective study enrolled 367 consecutive patients who underwent screening colonoscopy with the finding of serrated polyps. Patients were divided into derivation and validation cohorts: Diagnostic criteria using different endoscopic modalities were generated by regression analysis in the derivation cohort and were validated in the validation cohort for sensitivity, specificity, and accuracy...
July 7, 2017: Journal of Gastroenterology and Hepatology
Yi-Chia Lee, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Sherry Yueh-Hsia Chiu, Jean Ching-Yuan Fann, Shu-Lin Chuang, Tsung-Hsien Chiang, Chu-Kuang Chou, Han-Mo Chiu, Ming-Shiang Wu, Chien-Yuan Wu, Shu-Li Chia, Shu-Ti Chiou, Hsiu-Hsi Chen
Background: To what extent the risk for colorectal cancer (CRC) death among noncompliers of colonoscopy is elevated following positive fecal immunological testing and whether the elevated risk varies with the fecal hemoglobin concentration (f-Hb) and location of CRC have not been researched. Methods: We used data on 59 389 individuals (4.0%) among 1 489 937 Taiwanese screenees age 50 to 69 years with f-Hb 20 μg hemoglobin or more per gram of feces from 2004 to 2009...
May 1, 2017: Journal of the National Cancer Institute
Ping-Huei Tseng, Pei-Lin Lee, Wei-Chung Hsu, Yan Ma, Yi-Chia Lee, Han-Mo Chiu, Yi-Lwun Ho, Ming-Fong Chen, Ming-Shiang Wu, Chung-Kang Peng
OBJECTIVE: The prevalence of metabolic syndrome (MS) has increased rapidly in Taiwan and worldwide. We aim to determine the association between sleep-disordered breathing (SDB) and MS in a Chinese general population. METHODS: This case-control study recruited subjects who have undergone a prospective electrocardiogram-based cardiopulmonary coupling (CPC) sleep spectrogram as part of the periodic health check-ups at the National Taiwan University Hospital. Comprehensive anthropometrics, blood biochemistry, prevalence of MS and its individual components were compared with Bonferroni correction between 40 subjects with SDB, defined as the CPC-derived apnea-hypopnea index (CPC-AHI) >5 event/hour and 80 age- and sex-matched controls, defined as CPC-AHI <1 event/hour...
2017: PloS One
Shu-Lin Chuang, William Wang-Yu Su, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Cheng-Ping Wang, Jean Ching-Yuan Fann, Sherry Yueh-Hsia Chiu, Yi-Chia Lee, Han-Mo Chiu, Dun-Cheng Chang, Yann-Yuh Jou, Chien-Yuan Wu, Hsiu-Hsi Chen, Mu-Kuan Chen, Shu-Ti Chiou
BACKGROUND: To reduce oral cancer mortality, an organized, population-based screening program for the early detection of oral premalignancy and oral cancer was designed for high-risk individuals with habits of betel quid chewing, cigarette smoking, or both. The objective of this report was to evaluate the long-term effectiveness of this program in reducing the incidence of advanced disease and deaths from oral cancer. METHODS: A nationwide, population-based screening program for oral cancer has been conducted in Taiwan since 2004...
May 1, 2017: Cancer
Chun-Bing Chen, Yi-Hsin Hsiao, Tony Wu, Mo-Song Hsih, Wichittra Tassaneeyakul, Teekayu P Jorns, Chonlaphat Sukasem, Chien-Ning Hsu, Shih-Chi Su, Wan-Chun Chang, Rosaline Chung-Yee Hui, Chia-Yu Chu, Yi-Ju Chen, Ching-Ying Wu, Chao-Kai Hsu, Tsu-Man Chiu, Pei-Lun Sun, Hua-En Lee, Chin-Yi Yang, Pei-Han Kao, Chih-Hsun Yang, Hsin-Chun Ho, Jing-Yi Lin, Ya-Ching Chang, Ming-Jing Chen, Chun-Wei Lu, Chau Yee Ng, Kang-Ling Kuo, Chien-Yio Lin, Ching-Sheng Yang, Ding-Ping Chen, Pi-Yueh Chang, Tsu-Lan Wu, Yu-Jr Lin, Yi-Ching Weng, Tseng-Tong Kuo, Shuen-Iu Hung, Wen-Hung Chung
OBJECTIVE: To investigate the risk and genetic association of oxcarbazepine-induced cutaneous adverse reactions (OXC-cADRs), including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), in Asian populations (Chinese and Thai). METHODS: We prospectively enrolled patients with OXC-cADRs in Taiwan and Thailand from 2006 to 2014, and analyzed the clinical course, latent period, drug dosage, organ involvement, complications, and mortality. We also investigated the carrier rate of HLA-B*15:02 and HLA-A*31:01 of patients with OXC-cADRs and compared to OXC-tolerant controls...
January 3, 2017: Neurology
Abdullah Murdani, Ajay Kumar, Han-Mo Chiu, Khean-Lee Goh, Byung Ik Jang, Christopher J L Khor, James Lau, Ibrahim Mostafa, Mohan Ramchandani, Siriporn Ratanalert, Hisao Tajiri, Minghwa Yuen, Shu Tian Zhang, Dianelle Duforest-Rey, Jean-Francois Rey
The aim of this position statement is to reinforce the key points of hygiene in digestive endoscopy. The present article details the minimum hygiene requirements for reprocessing of endoscopes and endoscopic devices, regardless of the reprocessing method (automated washer-disinfector or manual cleaning) and the endoscopy setting (endoscopy suite, operating room, elective or emergency procedures). These minimum requirements are mandatory for patient safety. Both advanced diagnostic and therapeutic endoscopies should be carried out in an environment that is safe for patients and staff...
October 1, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Chu-Kuang Chou, Chi-Yang Chang, Chun-Chao Chang, Li-Chun Chang, Wen-Feng Hsu, Chi-Yi Chen, Hsiu-Po Wang, Han-Mo Chiu
BACKGROUND: Bowel preparation is burdensome, and less-demanding preparation procedures are needed. Few studies have investigated the effects of low-residue diet and prepackaged low-residue diet in combination with low-volume polyethylene glycol-electrolyte lavage solution during colonoscopy preparation. OBJECTIVE: We compared self-prepared low-residue diets with prepackaged low-residue diets in combination with low-volume polyethylene glycol. DESIGN: This was a single-blinded, 3-arm, multicenter, randomized controlled trial...
October 2016: Diseases of the Colon and Rectum
Li-Chun Chang, Chia-Tung Shun, Weng-Feng Hsu, Chia-Hong Tu, Pei-Yu Tsai, Been-Ren Lin, Jin-Tung Liang, Ming-Shiang Wu, Han-Mo Chiu
BACKGROUND & AIMS: The serrated pathway is a distinct pathway of colorectal carcinogenesis that has been implicated in development of a substantial proportion of interval colorectal cancers. The fecal immunochemical test (FIT) detects early neoplasms with a higher level of sensitivity than the guaiac test. We investigated the sensitivity of the FIT in detection of sessile serrated adenomas/polyps (SSA/Ps). METHODS: We performed a prospective study of 6198 asymptomatic subjects (mean age, 59...
August 4, 2016: Clinical Gastroenterology and Hepatology
Takahisa Matsuda, Masau Sekiguchi, Yasuo Kakugawa, Hiroaki Ikematsu, Yasuhiro Oono, Han-Mo Chiu, Yasushi Sano, Takahiro Fujii, Yutaka Saito
No abstract text is available yet for this article.
July 2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Chu-Kuang Chou, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Sherry Yueh-Hsia Chiu, Jean Ching-Yuan Fann, Han-Mo Chiu, Shu-Lin Chuang, Tsung-Hsien Chiang, Ming-Shiang Wu, Chien-Yuan Wu, Shu-Li Chia, Yi-Chia Lee, Shu-Ti Chiou, Hsiu-Hsi Chen
BACKGROUND: Outreach (i.e., to invite those who do not use, or who under use screening services) and inreach (i.e., to invite an existing population who have already accessed the medical system) approaches may influence people to increase their use of screening test; however, whether their outcomes would be equivalent remains unclear. METHODS: A total of 3,363,896 subjects, 50-69 years of age, participated in a colorectal cancer (CRC) screening program using biennial fecal immunochemical tests; 34...
2016: PloS One
Amy Ming-Fang Yen, Huei-Shian Tsau, Jean Ching-Yuan Fann, Sam Li-Sheng Chen, Sherry Yueh-Hsia Chiu, Yi-Chia Lee, Shin-Liang Pan, Han-Mo Chiu, Wen-Horng Kuo, King-Jen Chang, Yi-Ying Wu, Shu-Lin Chuang, Chen-Yang Hsu, Dun-Cheng Chang, Shing-Lang Koong, Chien-Yuan Wu, Shu-Lih Chia, Mei-Ju Chen, Hsiu-Hsi Chen, Shu-Ti Chiou
IMPORTANCE: Different screening strategies for breast cancer are available but have not been researched in quantitative detail. OBJECTIVE: To assess the benefits and the harms of risk-based and universal mammography screening in comparison with annual clinical breast examination (CBE). DESIGN: Population-based cohort study comparing incidences of stage II+ disease and death from breast cancer across 3 breast cancer screening strategies, with adjustment for a propensity score for participation based on risk factors for breast cancer and comparing the 3 strategies for overdetection between January 1999 and December 2009...
July 1, 2016: JAMA Oncology
Martin C S Wong, Jessica Y L Ching, Han-Mo Chiu, Kai Chun Wu, Rungsun Rerknimitr, Jingnan Li, Deng-Chiang Wu, Khean Lee Goh, Takahisa Matsuda, Hyun-Soo Kim, Rupert Leong, Khay Guan Yeoh, Vui Heng Chong, Jose D Sollano, Furqaan Ahmed, Jayaram Menon, Siew C Ng, Justin C Y Wu, Francis K L Chan, Joseph J Y Sung
OBJECTIVES: We tested the hypothesis that the risk of colorectal cancer (CRC), advanced colorectal neoplasia (ACN), and colorectal adenoma among screening participants with different first-degree relatives (FDRs) affected by CRC was similar. METHODS: A multi-center, prospective colonoscopy study involving 16 Asia-Pacific regions was performed from 2008 to 2015. Consecutive self-referred CRC screening participants aged 40-70 years were recruited, and each subject received one direct optical colonoscopy...
November 2016: American Journal of Gastroenterology
Yu-Ting Huang, Yu-Wei Lin, Han-Mo Chiu, Been-Huang Chiang
This study investigated the effect of curcumin on colorectal cancer stem cells (CCSCs) and its possible mechanism. Comparison of the metabolic profiles of human adenomatous polyp (N = 61) and colorectal cancer (CRC) (N = 57) tissue found statistically significant differences (p < 0.05) in their composition of adenosine monophosphate (AMP), adenine, 5'-methythioadenosine, 3-hydroxybutyric acid, prostaglandin E2, threonine, and glutamine. Our cell culture model study found that curcumin treatment (50 μM for 48 h) did indeed increase apoptosis of CRC cells as well as of CCSCs, but at a significant level only in CD44(+) cells...
March 23, 2016: Journal of Agricultural and Food Chemistry
Takahisa Matsuda, Han-Mo Chiu, Yasushi Sano, Takahiro Fujii, Akiko Ono, Yutaka Saito
Colonoscopy is considered the gold standard to detect and remove colorectal neoplasia. The efficacy of colonoscopy with polypectomy to reduce colorectal cancer incidence and mortality has been demonstrated. Recently, post-polypectomy surveillance colonoscopy has become a necessary intervention in daily practice not only in Western countries but also in the Asia-Pacific region. Therefore, it is crucial to establish new clinical practice guidelines to reduce the number of unnecessary surveillance colonoscopies in order to create space for screening colonoscopy...
April 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Han-Mo Chiu, Li-Chun Chang, Wen-Feng Hsu, Chu-Kuang Chou, Ming-Shiang Wu
There is an increasing trend of colorectal cancer incidence in Asia and nearly 45% of CRC cases worldwide occur in Asia therefore screening for CRC becomes an urgent task. Stool-based tests, including guaiac fecal occult blood test (gFOBT) and fecal immunochemical test (FIT), can select subjects at risk of significant colorectal neoplasms from the large target population thus are currently the most commonly used non-invasive screening tool in large population screening programs. FIT has the advantage over gFOBT in terms of higher sensitivity for early neoplasms, the ability to provide high-throughput automatic analysis, and better public acceptance thus greater effectiveness on reducing CRC mortality and incidence is expected...
December 2015: Best Practice & Research. Clinical Gastroenterology
Han-Mo Chiu, Jessica Y L Ching, Kai Chun Wu, Rungsun Rerknimitr, Jingnan Li, Deng-Chiang Wu, Khean Lee Goh, Takahisa Matsuda, Hyun-Soo Kim, Rupert Leong, Khay Guan Yeoh, Vui Heng Chong, Jose D Sollano, Furqaan Ahmed, Jayaram Menon, Joseph J Y Sung
BACKGROUND & AIMS: Age, sex, smoking, and family history are risk factors for colorectal cancer in Asia. The Asia-Pacific Colorectal Screening (APCS) scoring system was developed to identify subjects with a high risk for advanced neoplasm (AN). We tested an algorithm that combined APCS scores with fecal immunochemical test (FIT) in colorectal cancer screening. METHODS: We performed a multicenter prospective study, enrolling asymptomatic individuals older than 40 years old in 12 Asia-Pacific regions from December 2011 to December 2013...
March 2016: Gastroenterology
Yasushi Sano, Jeong-Sik Byeon, Xiao-Bo Li, Martin C S Wong, Han-Mo Chiu, Rungsun Rerknimitr, Takahiro Utsumi, Santa Hattori, Wataru Sano, Mineo Iwatate, Philip Chiu, Joseph Sung
In recent years, the incidence of colorectal cancer (CRC) has been increasing, and CRC has been becoming the major cause of cancer deaths in Asian countries. Therefore, an organized screening program to reduce CRC incidence and mortality is currently implemented in each country. In the present review, we summarize the current status and future perspectives of CRC screening of the general population in East Asian and South-East Asian countries. The fecal occult blood test is widely used for CRC screening in these countries, and its effectiveness in reducing CRC incidence and mortality has been demonstrated; however, the low participation rate in CRC screening programs is a problem to be solved in every country...
April 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Sherry Yueh-Hsia Chiu, Shu-Ling Chuang, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Jean Ching-Yuan Fann, Dun-Cheng Chang, Yi-Chia Lee, Ming-Shiang Wu, Chu-Kuang Chou, Wen-Feng Hsu, Shu-Ti Chiou, Han-Mo Chiu
OBJECTIVES: Interval colorectal cancer (CRC) after colonoscopy may affect effectiveness and cost-effectiveness of screening programmes. We aimed to investigate whether and how faecal haemoglobin concentration (FHbC) of faecal immunochemical testing (FIT) affected the risk prediction of interval cancer (IC) caused by inadequate colonoscopy quality in a FIT-based population screening programme. DESIGN: From 2004 to 2009, 29 969 subjects underwent complete colonoscopy after positive FIT in the Taiwanese Nationwide CRC Screening Program...
February 2017: Gut
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