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https://www.readbyqxmd.com/read/26908954/classifying-the-causes-of-perinatal-death
#1
EDITORIAL
Emma Allanson, Özge Tunçalp, Jason Gardosi, Robert C Pattinson, Jan Jaap Hm Erwich, Vicki J Flenady, J Frederik Frøen, James Neilson, Doris Chou, Matthews Mathai, Lale Say, Metin Gülmezoglu
No abstract text is available yet for this article.
February 1, 2016: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/25200099/difference-in-performance-of-fecal-immunochemical-tests-with-the-same-hemoglobin-cutoff-concentration-in-a-nationwide-colorectal-cancer-screening-program
#2
Tsung-Hsien Chiang, Shu-Lin Chuang, Sam Li-Sheng Chen, Han-Mo Chiu, Amy Ming-Fang Yen, Sherry Yueh-Hsia Chiu, Jean Ching-Yuan Fann, Chu-Kuang Chou, Yi-Chia Lee, Ming-Shiang Wu, Hsiu-Hsi Chen
BACKGROUND & AIMS: We investigated whether 2 quantitative fecal immunochemical tests (FITs) with the same cutoff concentration of fecal hemoglobin perform equivalently in identifying patients with colorectal cancer (CRC). METHODS: A total of 956,005 Taiwanese subjects, 50 to 69 years old, participated in a nationwide CRC screening program to compare results from 2 FITs; 78% were tested using the OC-Sensor (n = 747,076; Eiken Chemical Co, Tokyo, Japan) and 22% were tested using the HM-Jack (n = 208,929; Kyowa Medex Co Ltd, Tokyo, Japan), from 2004 through 2009...
December 2014: Gastroenterology
https://www.readbyqxmd.com/read/24723343/biomarker-discovery-for-neuroendocrine-cervical-cancer
#3
Li-Hsun Lin, Shing-Jyh Chang, Ren-Yu Hu, Meng-Wei Lin, Szu-Ting Lin, Shun-Hong Huang, Ping-Chiang Lyu, Hsiu-Chuan Chou, Zih-Yin Lai, Yung-Jen Chuang, Hong-Lin Chan
Neuroendocrine cervical cancer is an aggressive but rare form of cervical cancer. The majority of neuroendocrine cervical cancer patients present with advanced-stage diseases. However, the limited numbers of neuroendocrine tumor markers are insufficient for clinical purposes. Thus, we used a proteomic approach combining lysine labeling 2D-DIGE and MALDI-TOF MS to investigate the biomarkers for neuroendocrine cervical cancer. By analyzing the global proteome alteration between the neuroendocrine cervical cancer line (HM-1) and non-neuroendocrine cervical cancer lines (CaSki cells, ME-180 cells, and Hela cells), we identified 82 proteins exhibiting marked changes between HM-1 and CaSki cells, and between ME-180 and Hela cells...
July 2014: Electrophoresis
https://www.readbyqxmd.com/read/18775325/bypassing-sir2-and-o-acetyl-adp-ribose-in-transcriptional-silencing
#4
Chia-Ching Chou, Yao-Cheng Li, Marc R Gartenberg
The yeast Sir2/3/4 complex forms a heterochromatin-like structure that represses transcription. The proteins nucleate at silencers and spread distally, utilizing the Sir2 NAD(+)-dependent histone deacetylase activity and the affinity of Sir3/4 for deacetylated histone tails. A by-product of the Sir2 reaction, O-acetyl-ADP-ribose (OAADPr), is thought to aid spreading by binding one of the Sir proteins. We developed a protein chimera approach to reexamine the contributions of Sir2. We show that a Sir3 chimera-bearing Hos3, an unrelated NAD(+)-independent histone deacetylase, substitutes for Sir2 in silencing...
September 5, 2008: Molecular Cell
https://www.readbyqxmd.com/read/18703844/high-molecular-weight-polymers-for-protein-crystallization-poly-gamma-glutamic-acid-based-precipitants
#5
Ting Chou Hu, Justyna Korczyńska, David K Smith, Andrzej Marek Brzozowski
Protein crystallization has been revolutionized by the introduction of high-throughput technologies, which have led to a speeding up of the process while simultaneously reducing the amount of protein sample necessary. Nonetheless, the chemistry dimension of protein crystallization has remained relatively undeveloped. Most crystallization screens are based on the same set of precipitants. To address this shortcoming, the development of new protein precipitants based on poly-gamma-glutamic acid (PGA) polymers with different molecular-weight ranges is reported here: PGA-LM (low molecular weight) of approximately 400 kDa and PGA-HM (high molecular weight) of >1,000 kDa...
September 2008: Acta Crystallographica. Section D, Biological Crystallography
https://www.readbyqxmd.com/read/15690416/heuristic-molecular-lipophilicity-potential-hmlp-a-2d-qsar-study-to-ladh-of-molecular-family-pyrazole-and-derivatives
#6
Qishi Du, P G Mezey, Kuo-Chen Chou
The quantum chemical and structure-based technique heuristic molecular lipophilicity potential (HMLP) is used in the liver alcohol dehydrogenase (LADH) study of molecular family pyrazole and derivatives. The molecular lipophilic index LM, molecular hydrophilic index HM, lipophilic indices lss, and hydrophilic indices hss of the substitutes (fragments), and atomic lipophilicity indices las are constructed and used in QSAR study. The HMLP indices are correlated with bioactivities of 18 pyrazole derivatives according to the 2D QSAR procedure...
April 15, 2005: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/11753431/crystal-structure-of-pea-toc34-a-novel-gtpase-of-the-chloroplast-protein-translocon
#7
Yuh-Ju Sun, Farhad Forouhar, Hsou-min Li Hm, Shuh-Long Tu, Yi-Hong Yeh, Sen Kao, Hui-Lin Shr, Chia-Cheng Chou, Chinpan Chen, Chwan-Deng Hsiao
Toc34, a 34-kDa integral membrane protein, is a member of the Toc (translocon at the outer-envelope membrane of chloroplasts) complex, which associates with precursor proteins during protein transport across the chloroplast outer membrane. Here we report the 2.0 A resolution crystal structure of the cytosolic part of pea Toc34 in complex with GDP and Mg2+. In the crystal, Toc34 molecules exist as dimers with features resembling those found in a small GTPase in complex with a GTPase activating protein (GAP)...
February 2002: Nature Structural Biology
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