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yutaka Saito

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https://www.readbyqxmd.com/read/29908178/new-generation-full-spectrum-endoscopy-versus-standard-forward-viewing-colonoscopy-a-multicenter-randomized-tandem-colonoscopy-trial-j-fuse-study
#1
Toyoki Kudo, Yutaka Saito, Hiroaki Ikematsu, Kinichi Hotta, Yoji Takeuchi, Masaaki Shimatani, Ken Kawakami, Naoto Tamai, Yuichi Mori, Yasuharu Maeda, Masayoshi Yamada, Taku Sakamoto, Takahisa Matsuda, Kenichiro Imai, Sayo Ito, Kenta Hamada, Norimasa Fukata, Takuya Inoue, Hisao Tajiri, Kenichi Yoshimura, Hideki Ishikawa, Shin-Ei Kudo
OBJECTIVES: Although colonoscopy is the criterion standard for detection of colorectal adenomas, some adenomas are missed. Full-spectrum endoscopy (FUSE) allows for observation with a 330° angle of view, which is expected to decrease the miss rate. However, no consensus has been reached regarding the superiority of FUSE over standard forward-viewing colonoscopy (SFVC) for detection of adenomas; we therefore compared new-generation FUSE and SFVC regarding colorectal adenoma miss rate (AMR) in this, the first reported randomized control trial using new-generation FUSE...
June 13, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29885651/the-influence-of-patient-factors-on-femoral-rotation-after-total-hip-arthroplasty
#2
Taro Tezuka, Yutaka Inaba, Naomi Kobayashi, Hyonmin Choe, Syota Higashihira, Tomoyuki Saito
BACKGROUND: A postoperative change in femoral rotation following total hip arthroplasty (THA) might be the cause of dislocation due to the change in combined anteversion. However, very few studies have evaluated the femoral rotation angle following THA, or the factors that influence femoral rotation. We aimed to evaluate changes in femoral rotation after THA, and to investigate preoperative patient factors that influence femoral rotation after THA. METHODS: This study involved 211 hips treated with primary THA...
June 9, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29883254/time-dependent-changes-of-the-intention-of-mothers-in-japan-to-inoculate-their-daughters-with-the-hpv-vaccine-after-suspension-of-governmental-recommendation
#3
Asami Yagi, Yutaka Ueda, Yusuke Tanaka, Ruriko Nakae, Reisa Kakubari, Akiko Morimoto, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Noriomi Matsumura, Kiyoshi Yoshino, Tadashi Kimura, Junko Saito, Sayaka Ikeda, Mikiko Asai-Sato, Etsuko Miyagi, Masayuki Sekine, Takayuki Enomoto, Kei Hirai, Yorihiko Horikoshi, Tetsu Takagi, Kentaro Shimura
In Japan, the trend for cervical cancer at younger ages has been increasing. As a countermeasure, the HPV vaccine was introduced as a routine vaccination in April 2013. However, the Ministry of Health, Labour and Welfare (MHLW) announced a "Suspension of its active inoculation recommendation for HPV vaccine" in June 2013. In 2016, 32 months after that suspension, we conducted survey via Internet and compared the results with our previous ones conducted at 9 and 23 months after suspension (in 2014 and 2015, respectively)...
June 8, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29868411/computer-assisted-hip-arthroscopic-surgery-for-femoroacetabular-impingement
#4
Naomi Kobayashi, Yutaka Inaba, So Kubota, Shota Higashihira, Hyonmin Choe, Hiroyuki Ike, Daigo Kobayashi, Tomoyuki Saito
Precise osteochondroplasty is key for success in hip arthroscopic surgery, especially for femoroacetabular impingement (FAI) caused by cam or pincer morphology. In this Technical Note, we present computer-assisted hip arthroscopic surgery for FAI, including preoperative planning by virtual osteochondroplasty and intraoperative computer navigation assistance. The important concept of this technique is that navigation assistance for osteochondroplasty is based on planning made by computer simulation analysis...
April 2018: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29846588/glucose-dependent-insulinotropic-polypeptide-suppresses-peripheral-arterial-remodeling-in-male-mice
#5
Yusaku Mori, Hideki Kushima, Masakazu Koshibu, Tomomi Saito, Munenori Hiromura, Kyoko Kohashi, Michishige Terasaki, Yutaka Seino, Yuichiro Yamada, Tsutomu Hirano
Glucose-dependent insulinotropic polypeptide (GIP) exhibits direct cardiovascular actions in addition to its well-known insulinotropic effect. However, the role of GIP in peripheral artery disease remains unclear. Here we evaluated the effects of GIP against peripheral arterial remodeling in mouse models. The genetic deletion of GIPR led to exaggerated neointimal hyperplasia after transluminal femoral artery wire injury. Conversely, chronic GIP infusion suppressed neointimal hyperplasia and facilitated endothelial regeneration...
May 28, 2018: Endocrinology
https://www.readbyqxmd.com/read/29802255/cd11c-m1-like-macrophages-m%C3%AE-s-but-not-cd206-m2-like-m%C3%AE-are-involved-in-folliculogenesis-in-mice-ovary
#6
Yosuke Ono, Miwako Nagai, Osamu Yoshino, Kaori Koga, Allah Nawaz, Hideki Hatta, Hirofumi Nishizono, Gentaro Izumi, Akitoshi Nakashima, Johji Imura, Kazuyuki Tobe, Tomoyuki Fujii, Yutaka Osuga, Shigeru Saito
Macrophages (MΦs) are involved in folliculogenesis and ovulation. However, it is unknown which type of MΦ, M1 or M2, plays a more essential role in the ovary. CD206 or CD11c diphtheria toxin receptor transgenic (DTR) mice, which enable depletion of CD206+ M2 MΦs and CD11c+ MΦ or CD11c+ Dendritic cells (DCs), respectively, were used. Oocytes were used for in vitro fertilization and embryo transfer. In vitro fertilized embryos derived from M2 MΦ depleted oocytes were transferred to pseudo pregnant wild type mice...
May 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789649/superficially-serrated-adenoma-a-proposal-for-a-novel-subtype-of-colorectal-serrated-lesion
#7
Taiki Hashimoto, Yusaku Tanaka, Reiko Ogawa, Taisuke Mori, Hiroshi Yoshida, Hirokazu Taniguchi, Nobuyoshi Hiraoka, Motohiro Kojima, Yasuhiro Oono, Yutaka Saito, Shigeki Sekine
We describe a series of colorectal polyps characterized by mixed adenomatous and serrated features, herein referred to as superficially serrated adenomas. Twenty superficially serrated adenomas were obtained from 11 female and 9 male patients aged 62-87 years. Most lesions endoscopically appeared as small sessile polyps, but larger lesions were plaque-like (2-20 mm; median, 5 mm). Eighteen lesions (90%) were located in the sigmoid colon or rectum. They consisted primarily of straight, adenomatous glands but showed serration confined to the superficial layer...
May 22, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29788999/the-first-case-of-multiple-pulmonary-granulomas-with-amyloid-deposition-in-a-dental-technician-a-rare-manifestation-as-an-occupational-lung-disease
#8
Taizou Hirano, Tadahisa Numakura, Hiroshi Moriyama, Ryoko Saito, Yutaka Shishikura, Jun Shiihara, Hisatoshi Sugiura, Masakazu Ichinose
BACKGROUND: Occupational lung diseases, such as pneumoconiosis, are one of the health problems of dental workers that have been receiving increasing interest. Pulmonary amyloidosis is a heterogenous group of diseases, and can be classified into primary (idiopathic) and secondary (associated with various inflammatory diseases, hereditary, or neoplastic). To date, the development of pulmonary amyloidosis in dental workers has not been reported. CASE PRESENTATION: A 58-year-old Japanese female presented with chest discomfort and low-grade fever that has persisted for 2 months...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29765561/a-pilot-study-of-peptide-vaccines-for-vegf-receptor-1-and-2-in-patients-with-recurrent-progressive-high-grade-glioma
#9
Shunsuke Shibao, Ryo Ueda, Katsuya Saito, Ryogo Kikuchi, Hideaki Nagashima, Atsuhiro Kojima, Hiroshi Kagami, Eriel Sandika Pareira, Hikaru Sasaki, Shinobu Noji, Yutaka Kawakami, Kazunari Yoshida, Masahiro Toda
Object: Early-phase clinical studies of glioma vaccines have shown feasibility and encouraging preliminary clinical activity. A vaccine that targets tumor angiogenesis factors in glioma microenvironment has not been reported. Therefore, we performed a pilot study to evaluate the safety and immunogenicity of a novel vaccination targeting tumor angiogenesis with synthetic peptides for vascular endothelial growth factor (VEGF) receptor epitopes in patients with recurrent/progressive high grade gliomas...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29735587/high-dose-versus-low-dose-pitavastatin-in-japanese-patients-with-stable-coronary-artery-disease-real-cad-a-randomized-superiority-trial
#10
Isao Taguchi, Satoshi Iimuro, Hiroshi Iwata, Hiroaki Takashima, Mitsuru Abe, Eisuke Amiya, Takanori Ogawa, Yukio Ozaki, Ichiro Sakuma, Yoshihisa Nakagawa, Kiyoshi Hibi, Takafumi Hiro, Yoshihiro Fukumoto, Seiji Hokimoto, Katsumi Miyauchi, Tsutomu Yamazaki, Hiroshi Ito, Yutaka Otsuji, Kazuo Kimura, Jun Takahashi, Atsushi Hirayama, Hiroyoshi Yokoi, Kazuo Kitagawa, Takao Urabe, Yasushi Okada, Yasuo Terayama, Kazunori Toyoda, Takehiko Nagao, Masayasu Matsumoto, Yasuo Ohashi, Tetsuji Kaneko, Retsu Fujita, Hiroshi Ohtsu, Hisao Ogawa, Hiroyuki Daida, Hiroaki Shimokawa, Yasushi Saito, Takeshi Kimura, Teruo Inoue, Masunori Matsuzaki, Ryozo Nagai
BACKGROUND: Current guidelines call for high-intensity statin therapy in patients with cardiovascular disease on the basis of several previous "more versus less statins" trials. However, no clear evidence for more versus less statins has been established in an Asian population. METHODS: In this prospective, multicenter, randomized, open-label, blinded end point study, 13 054 Japanese patients with stable coronary artery disease who achieved low-density lipoprotein cholesterol (LDL-C) <120 mg/dL during a run-in period (pitavastatin 1 mg/d) were randomized in a 1-to-1 fashion to high-dose (pitavastatin 4 mg/d; n=6526) or low-dose (pitavastatin 1 mg/d; n=6528) statin therapy...
May 8, 2018: Circulation
https://www.readbyqxmd.com/read/29713910/employment-status-and-termination-among-survivors-of-pediatric-brain-tumors-a-cross-sectional-survey
#11
Iori Sato, Akiko Higuchi, Takaaki Yanagisawa, Shiho Murayama, Toshihiro Kumabe, Kazuhiko Sugiyama, Akitake Mukasa, Nobuhito Saito, Yutaka Sawamura, Mizuhiko Terasaki, Soichiro Shibui, Jun Takahashi, Ryo Nishikawa, Yasushi Ishida, Kiyoko Kamibeppu
BACKGROUND: Some childhood cancer survivors experience employment difficulties. This study aimed to describe pediatric brain-tumor survivors' employment status. METHODS: A cross-sectional, observational study was conducted, with questionnaires distributed to 101 pediatric brain-tumor survivors (aged 15 years or older) and their attending physicians from nine institutions in Japan. We compared category and time-series histories for participants' first-time employment using national census information...
April 30, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29709915/hydrogen-peroxide-reducing-factor-released-by-pc12d-cells-increases-cell-tolerance-against-oxidative-stress
#12
Asami Muraishi, Emi Haneta, Yoshiro Saito, Yutaka Hitomi, Mamoru Sano, Noriko Noguchi
PC12D cells, a subline of rat adrenal pheochromocytoma PC12 cells, extend neurites rapidly in response to differentiation stimuli and are used to investigate the molecular mechanisms of neurite extension. In the present study, we found significant tolerance of PC12D cells against Parkinson's disease-related stimuli such as dopamine and 6-hydroxydopamine; this tolerance was significantly decreased by a change in the medium. Conditioned medium from PC12D cells induced tolerance against oxidative stress, which suggests that cytoprotective factor may be released by PC12D cells into the culture medium...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29700599/pilot-study-on-probe-based-confocal-laser-endomicroscopy-for-colorectal-neoplasms-an-initial-experience-in-japan
#13
Seiichiro Abe, Yutaka Saito, Yasuhiro Oono, Yusaku Tanaka, Taku Sakamoto, Masayoshi Yamada, Takeshi Nakajima, Takahisa Matsuda, Hiroaki Ikematsu, Tomonori Yano, Shigeki Sekine, Motohiro Kojima, Hidetsugu Yamagishi, Hiroyuki Kato
BACKGROUND: The aim of this pilot study is to investigate the diagnostic yield of probe-based confocal laser endomicroscopy (pCLE) in the evaluation of depth of invasion in colorectal lesions. METHODS: Patients with colorectal lesions eligible for either endoscopic treatment or surgery were enrolled in the study. Tumor's depth of invasion was classified as mucosal or slight submucosal (M-SM1) and deep submucosal invasion or deeper (SM2 or deeper). White light endoscopy (WLE), magnifying narrow band imaging (M-NBI), and magnifying chromoendoscopy (M-CE) were used to assess colorectal lesions, and pCLE was used to identify tumor's features related to SM2 or deeper...
April 26, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29699614/neoatherosclerosis-5-years-after-bioresorbable-vascular-scaffold-implantation
#14
Noriaki Moriyama, Koki Shishido, Yutaka Tanaka, Shohei Yokota, Takahiro Hayashi, Hirokazu Miyashita, Tatsuya Koike, Hiroaki Yokoyama, Takuma Takada, Takashi Nishimoto, Tomoki Ochiai, Kazuki Tobita, Futoshi Yamanaka, Shingo Mizuno, Masato Murakami, Saeko Takahashi, Shigeru Saito
BACKGROUND: Data regarding neoatherosclerosis after everolimus-eluting bioresorbable vascular scaffold (BVS) (ABSORB BVS Rev. 1.1, Abbott Vascular, Santa Clara, California) implantation are limited. OBJECTIVES: This study investigated the findings of neoatherosclerosis at 5 years after BVS 1.1 implantation by using multi-imaging modalities, including optical coherence tomography (OCT). METHODS: Patients included in the ABSORB EXTEND (ABSORB EXTEND Clinical Investigation) trial at Shonan Kamakura General Hospital underwent OCT at baseline after the index procedure and at 1 and 5 years...
May 1, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29682811/upregulation-of-hypothalamic-arginine-vasopressin-by-peripherally-administered-furosemide-in-transgenic-rats-expressing-arginine-vasopressin-enhanced-green-fluorescent-protein
#15
Hiromichi Ueno, Mitsuhiro Yoshimura, Kentaro Tanaka, Haruki Nishimura, Kazuaki Nishimura, Satomi Sonoda, Yasuhito Motojima, Reiko Saito, Takashi Maruyama, Tetsu Miyamoto, Ryota Serino, Masahito Tamura, Tatsushi Onaka, Yutaka Otsuji, Yoichi Ueta
Furosemide, which is used worldwide as a diuretic agent, inhibits sodium reabsorption in the Henle's loop, resulting in diuresis and natriuresis. Arginine vasopressin (AVP) is synthesized in the supraoptic nucleus (SON), paraventricular nucleus (PVN), and suprachiasmatic nucleus (SCN) of the hypothalamus. The synthesis AVP in the magnocellular neurons of SON and PVN physiologically regulated by plasma osmolality and blood volume and contributed water homeostasis by increasing water reabsorption in the collecting duct...
April 22, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29663558/usefulness-of-bcor-gene-mutation-as-a-prognostic-factor-in-acute-myeloid-leukemia-with-intermediate-cytogenetic-prognosis
#16
Kazuki Terada, Hiroki Yamaguchi, Toshimitsu Ueki, Kensuke Usuki, Yutaka Kobayashi, Kenji Tajika, Seiji Gomi, Saiko Kurosawa, Riho Saito, Yutaka Furuta, Keiki Miyadera, Taichiro Tokura, Atushi Marumo, Ikuko Omori, Masahiro Sakaguchi, Yusuke Fujiwara, Shunsuke Yui, Takeshi Ryotokuji, Kunihito Arai, Tomoaki Kitano, Satoshi Wakita, Takahiro Fukuda, Koiti Inokuchi
BCOR gene is a transcription regulatory factor that plays an essential role in normal hematopoiesis. The wider introduction of next-generation sequencing technology has led to reports in recent years of mutations in the BCOR gene in acute myeloid leukemia (AML), but the related clinical characteristics and prognosis are not sufficiently understood. We investigated the clinical characteristics and prognosis of 377 de novo AML cases with BCOR or BCORL1 mutation. BCOR or BCORL1 gene mutations were found in 28 cases (7...
April 16, 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29656581/japan-nbi-expert-team-classification-narrow-band-imaging-magnifying-endoscopic-classification-of-colorectal-tumors
#17
Yasushi Sano, Daizen Hirata, Yutaka Saito
No abstract text is available yet for this article.
April 14, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29650932/-a-case-of-sigmoid-colon-cancer-with-locally-advanced-infiltration-curatively-resected-after-capeox-therapy
#18
Yuki Suematsu, Mao Nakayama, Shunsuke Yamagishi, Hiroyuki Saito, Miyuki Takahashi, Kyohei Kanematsu, Michiko Fukabori, Kazuhiko Wakabayashi, Yutaka Itoh
A 68-year-old man presented with malaise and abdominal swelling.Lower gastrointestinal endoscopy revealed a type 2 circumferential sigmoid colon cancer.Computed tomography suggested the cancer infiltrating bladder and abdominal wall with abscess.Because of locally advanced infiltration, the patient was treated with capecitabine plus oxaliplatin(CapeOX) plus bevacizumab therapy after loop-colostomy.After 2 courses of chemotherapy, a CT revealed tumor reduction and increased abscess, which was punctured drainage...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29643916/antireflux-metal-stent-for-initial-treatment-of-malignant-distal-biliary-obstruction
#19
Shinichi Morita, Yasuaki Arai, Shunsuke Sugawara, Miyuki Sone, Yasunari Sakamoto, Takuji Okusaka, Shigetaka Yoshinaga, Yutaka Saito, Shuji Terai
Objectives: To compare the use of an antireflux metal stent (ARMS) with that of a conventional covered self-expandable metal stent (c-CSEMS) for initial stenting of malignant distal biliary obstruction (MDBO). Materials and Methods: We retrospectively investigated 59 consecutive patients with unresectable MDBO undergoing initial endoscopic biliary drainage. ARMS was used in 32 patients and c-CSEMS in 27. Technical success, functional success, complications, causes of recurrent biliary obstruction (RBO), time to RBO (TRBO), and reintervention were compared between the groups...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29643697/vascular-healing-response-after-everolimus-eluting-stent-implantation-in-acute-coronary-syndrome-culprit-lesions-comparison-with-implantation-in-stable-angina-pectoris
#20
Yutaka Goryo, Teruyoshi Kume, Tomoya Ueda, Makoto Watanabe, Ryotaro Yamada, Yoji Neishi, Yoshihiko Saito, Shiro Uemura
Background: To evaluate the neointimal conditions of everolimus-eluting stents (EESs) implanted in culprit lesions of patients with acute coronary syndrome (ACS) compared with stable angina pectoris (SAP) using optical coherence tomography (OCT). EESs are second-generation drug-eluting stents that have recently been shown to be useful in patients with ACS as well as in patients with SAP. However, few studies have analyzed the intra-stent conditions of EESs that can lead to favorable results in such ACS lesions...
March 2018: Acta Cardiologica Sinica
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