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https://www.readbyqxmd.com/read/29656581/the-jnet-classification-nbi-magnifying-endoscopic-classification-of-colorectal-tumors
#1
Yasushi Sano, Daizen Hirata, Yutaka Saito
The NICE classification is widely used around the world as a universal NBI endoscopic classification that is available without magnifying endoscopy. On the other hand, as histopathological criteria of curative endoscopic resection for early colorectal cancers is getting clear in Japan, endoscopists are required to diagnose their invasion depth accurately with magnifying endoscopy and obtain deeper histopathological materials by endoscopic mucosal resection (EMR)/endoscopic submucosal dissection (ESD). Therefore, we need a new classification which provides accurate qualitative and quantitative diagnosis linking to the appropriate treatment strategy including polypectomy, EMR/ESD, and surgery...
April 14, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29650932/-a-case-of-sigmoid-colon-cancer-with-locally-advanced-infiltration-curatively-resected-after-capeox-therapy
#2
Yuki Suematsu, Mao Nakayama, Shunsuke Yamagishi, Hiroyuki Saito, Miyuki Takahashi, Kyohei Kanematsu, Michiko Fukabori, Kazuhiko Wakabayashi, Yutaka Itoh
A 68-year-old man presented with malaise and abdominal swelling.Lower gastrointestinal endoscopy revealed a type 2 circumferential sigmoid colon cancer.Computed tomography suggested the cancer infiltrating bladder and abdominal wall with abscess.Because of locally advanced infiltration, the patient was treated with capecitabine plus oxaliplatin(CapeOX) plus bevacizumab therapy after loop-colostomy.After 2 courses of chemotherapy, a CT revealed tumor reduction and increased abscess, which was punctured drainage...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29643916/antireflux-metal-stent-for-initial-treatment-of-malignant-distal-biliary-obstruction
#3
Shinichi Morita, Yasuaki Arai, Shunsuke Sugawara, Miyuki Sone, Yasunari Sakamoto, Takuji Okusaka, Shigetaka Yoshinaga, Yutaka Saito, Shuji Terai
Objectives: To compare the use of an antireflux metal stent (ARMS) with that of a conventional covered self-expandable metal stent (c-CSEMS) for initial stenting of malignant distal biliary obstruction (MDBO). Materials and Methods: We retrospectively investigated 59 consecutive patients with unresectable MDBO undergoing initial endoscopic biliary drainage. ARMS was used in 32 patients and c-CSEMS in 27. Technical success, functional success, complications, causes of recurrent biliary obstruction (RBO), time to RBO (TRBO), and reintervention were compared between the groups...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29643697/vascular-healing-response-after-everolimus-eluting-stent-implantation-in-acute-coronary-syndrome-culprit-lesions-comparison-with-implantation-in-stable-angina-pectoris
#4
Yutaka Goryo, Teruyoshi Kume, Tomoya Ueda, Makoto Watanabe, Ryotaro Yamada, Yoji Neishi, Yoshihiko Saito, Shiro Uemura
Background: To evaluate the neointimal conditions of everolimus-eluting stents (EESs) implanted in culprit lesions of patients with acute coronary syndrome (ACS) compared with stable angina pectoris (SAP) using optical coherence tomography (OCT). EESs are second-generation drug-eluting stents that have recently been shown to be useful in patients with ACS as well as in patients with SAP. However, few studies have analyzed the intra-stent conditions of EESs that can lead to favorable results in such ACS lesions...
March 2018: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29619992/bullous-pemphigoid-accompanied-by-iga-nephropathy-and-atypical-haemolytic-uraemic-syndrome
#5
Kazumasa Oya, Rei Watanabe, Sae Inoue, Naoshi Obara, Yusuke Kiyoki, Mamiko Sakata-Yanagimoto, Shigeru Chiba, Chie Saito, Yutaka Matsumura, Yoshiyuki Nakamura, Yosuke Ishitsuka, Hiroshi Maruyama, Naoko Okiyama, Yasuhiro Fujisawa, Manabu Fujimoto
No abstract text is available yet for this article.
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29607945/atrial-fibrillation-had-less-impact-on-the-risk-of-ischemic-stroke-in-non-anticoagulated-patients-undergoing-hemodialysis-insight-from-the-rakuen-study
#6
Wataru Mitsuma, Taku Matsubara, Katsuharu Hatada, Shunsuke Imai, Makoto Tamura, Yutaka Tsubata, Kozo Ikarashi, Tetsuo Morioka, Noriko Saito, Hisaki Shimada, Shigeru Miyazaki
Objective The progress of non-anticoagulated patients with atrial fibrillation (AF) undergoing hemodialysis has not been determined. Using data from the RAKUEN (Registry of Atrial fibrillation in chronic Kidney disease Under hEmodialysis from Niigata) study, we examined the clinical characteristics and outcomes among hemodialysis patients with AF who were not receiving a vitamin K antagonist (VKA). Methods and Results Forty-three of 423 patients undergoing hemodialysis (-10%) were prescribed a VKA. The remaining 380 patients (age 64...
March 30, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29603399/validation-study-for-development-of-the-japan-nbi-expert-team-jnet-classification-of-colorectal-lesions
#7
Mineo Iwatate, Yasushi Sano, Shinji Tanaka, Shin-Ei Kudo, Shoichi Saito, Takahisa Matsuda, Yoshiki Wada, Takahiro Fujii, Hiroaki Ikematsu, Toshio Uraoka, Nozomu Kobayashi, Hisashi Nakamura, Kinichi Hotta, Takahiro Horimatsu, Naoto Sakamoto, Kuang-I Fu, Osamu Tsuruta, Hiroshi Kawano, Hiroshi Kashida, Yoji Takeuchi, Hirohisa Machida, Toshihiro Kusaka, Naohisa Yoshida, Ichiro Hirata, Takeshi Terai, Hiro-O Yamano, Takeshi Nakajima, Taku Sakamoto, Yuichiro Yamaguchi, Naoto Tamai, Naoko Nakano, Nana Hayashi, Shiro Oka, Hideki Ishikawa, Yoshitaka Murakami, Shigeaki Yoshida, Yutaka Saito
OBJECTIVE: The Japan NBI Expert Team (JNET) was organized to unify four previous magnifying NBI classifications (the Sano, Hiroshima, Showa, and Jikei classifications). The JNET working group created criteria (referred to as the NBI scale) for evaluation of vessel pattern (VP) and surface pattern (SP). We conducted a multicenter validation study of the NBI scale to develop the JNET classification of colorectal lesions. METHODS: Twenty-five expert JNET colonoscopists read 100 still NBI images with and without magnification on the web to evaluate the NBI findings and the necessity of the criteria for the final diagnosis...
March 30, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29601346/low-bone-mineral-density-in-elite-female-athletes-with-a-history-of-secondary-amenorrhea-in-their-teens
#8
Sayaka Nose-Ogura, Osamu Yoshino, Michiko Dohi, Mika Kigawa, Miyuki Harada, Takashi Kawahara, Yutaka Osuga, Shigeru Saito
OBJECTIVE: To determine whether secondary amenorrhea during teenage years influences bone mineral density (BMD) in female athletes in their 20s. DESIGN: Original research. SETTING: Japan Institute of Sports Sciences. PARTICIPANTS: Two hundred ten elite female athletes older than 20 years were included in the study. MAIN OUTCOME MEASURES: Information on the participants' past (ie, during their teenage years) and current menstrual cycle, training time, history of stress fractures, and blood tests for hormones received was obtained...
March 27, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29596567/malignant-disease-as-a-comorbidity-in-patients-with-severe-aortic-stenosis-clinical-presentation-outcomes-and-management
#9
Eri Minamino-Muta, Takao Kato, Takeshi Morimoto, Tomohiko Taniguchi, Kenji Nakatsuma, Yuki Kimura, Moriaki Inoko, Shinichi Shirai, Norio Kanamori, Koichiro Murata, Takeshi Kitai, Yuichi Kawase, Makoto Miyake, Chisato Izumi, Hirokazu Mitsuoka, Yutaka Hirano, Tomoki Sasa, Kazuya Nagao, Tsukasa Inada, Ryusuke Nishikawa, Yasuyo Takeuchi, Shintaro Yamagami, Keiichiro Yamane, Kanae Su, Akihiro Komasa, Katsuhisa Ishii, Yugo Yamashita, Yoshihiro Kato, Kensuke Takabayashi, Naritatsu Saito, Kenji Minatoya, Takeshi Kimura
Aim: To investigate the effect of malignancy on the outcomes of patients with severe aortic stenosis (AS) and the management strategy for AS with malignancy. Methods: Using data of 3815 patients with severe AS in a retrospective multicenter registry (CURRENT AS registry), we compared 3-year clinical outcomes among three groups based on malignancy status: with malignancy currently under treatment including best supportive care (malignancy group), with a history of malignancy without any current treatment (past history group), or without history of malignancy (no malignancy group)...
March 27, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29569309/patterns-of-reproductive-isolation-in-a-haplodiploid-strong-postmating-prezygotic-barriers-among-three-forms-of-a-social-spider-mite
#10
Yukie Sato, Hironori Sakamoto, Tetsuo Gotoh, Yutaka Saito, Jung-Tai Chao, Martijn Egas, Atsushi Mochizuki
In speciation research, much attention is paid to the evolution of reproductive barriers, preventing diverging groups from hybridizing back into one gene pool. The prevalent view is that reproductive barriers evolve gradually as a byproduct of genetic changes accumulated by natural selection and genetic drift in groups that are segregated spatially and/or temporally. Reproductive barriers, however, can also be reinforced by natural selection against maladaptive hybridization. These mutually compatible theories are both empirically supported by studies, analyzing relationships between intensity of reproductive isolation and genetic distance in sympatric taxa and allopatric taxa...
March 22, 2018: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29566399/endocuff-assisted-underwater-snare-polypectomy-in-complex-ascending-colon-neoplasia
#11
Taku Sakamoto, Seiichiro Abe, Marina Kaori Yoshida, Yusaku Tanaka, Yutaka Saito
No abstract text is available yet for this article.
March 22, 2018: Endoscopy
https://www.readbyqxmd.com/read/29553111/-sensitization-pattern-for-inhaled-and-food-allergens-in-japanese-recurrent-wheezers-under-60-months-of-age
#12
Mari Saito, Yutaka Kikuchi, Alan Kawarai Lefor, Wakamichi Shimamura
BACKGROUND: Allergen sensitization differs according to countries and regions. Understanding the characteristics of allergen sensitization in one's own country is useful for the treatment of patients with allergic diseases. Recently, Japanese cedar pollen (JCP) sensitization is increasing in young Japanese children. Therefore, we evaluated allergen sensitization patterns in under 60-month-old Japanese recurrent wheezers using multiple allergen tests. METHODS: Allergen tests for 204 Japanese recurrent wheezers between April 2010 and April 2016 were reviewed...
2018: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29544953/quantitative-assessment-of-paravalvular-leakage-after-transcatheter-aortic-valve-replacement-using-a-patient-specific-pulsatile-flow-model
#13
Yutaka Tanaka, Shigeru Saito, Saeko Sasuga, Azuma Takahashi, Yusuke Aoyama, Kazuto Obama, Mitsuo Umezu, Kiyotaka Iwasaki
BACKGROUND: Quantitative assessment of post-transcatheter aortic valve replacement (TAVR) aortic regurgitation (AR) remains challenging. We developed patient-specific anatomical models with pulsatile flow circuit and investigated factors associated with AR after TAVR. METHODS: Based on pre-procedural computed tomography (CT) data of the six patients who underwent transfemoral TAVR using a 23-mm SAPIEN XT, anatomically and mechanically equivalent aortic valve models were developed...
May 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29508236/mortality-impact-of-post-discharge-myocardial-infarction-size-after-percutaneous-coronary-intervention-a-patient-level-pooled-analysis-from-the-4-large-scale-japanese-studies
#14
Hirotoshi Watanabe, Takeshi Morimoto, Hiroki Shiomi, Yusuke Yoshikawa, Takao Kato, Naritatsu Saito, Satoshi Shizuta, Koh Ono, Kyohei Yamaji, Kenji Ando, Shuichiro Kaji, Yutaka Furukawa, Masaharu Akao, Tetsuya Ishikawa, Takashi Tamura, Yoshito Yamamoto, Toshiya Muramatsu, Satoru Suwa, Yoshihisa Nakagawa, Kazushige Kadota, Yoshiki Takatsu, Hideo Nishikawa, Yoshikazu Hiasa, Yasuhiko Hayashi, Shunichi Miyazaki, Takeshi Kimura
It is unknown whether there is a threshold of creatine kinase (CK) or CK-MB affecting the subsequent mortality for post-discharge myocardial infarction (PDMI) after percutaneous coronary intervention. Current study sought to evaluate the impact of PDMI. The study population included 30,051 patients with successful coronary stenting and discharged alive in the pooled patient-level database of 4 Japanese studies (j-Cypher registry, CREDO-Kyoto PCI/CABG registry cohort-2, RESET, and NEXT). During 4.4 ± 1...
March 5, 2018: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/29507423/expansions-of-intronic-tttca-and-tttta-repeats-in-benign-adult-familial-myoclonic-epilepsy
#15
Hiroyuki Ishiura, Koichiro Doi, Jun Mitsui, Jun Yoshimura, Miho Kawabe Matsukawa, Asao Fujiyama, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Yutaka Suzuki, Sumio Sugano, Wei Qu, Kazuki Ichikawa, Hideaki Yurino, Koichiro Higasa, Shota Shibata, Aki Mitsue, Masaki Tanaka, Yaeko Ichikawa, Yuji Takahashi, Hidetoshi Date, Takashi Matsukawa, Junko Kanda, Fumiko Kusunoki Nakamoto, Mana Higashihara, Koji Abe, Ryoko Koike, Mutsuo Sasagawa, Yasuko Kuroha, Naoya Hasegawa, Norio Kanesawa, Takayuki Kondo, Takefumi Hitomi, Masayoshi Tada, Hiroki Takano, Yutaka Saito, Kazuhiro Sanpei, Osamu Onodera, Masatoyo Nishizawa, Masayuki Nakamura, Takeshi Yasuda, Yoshio Sakiyama, Mieko Otsuka, Akira Ueki, Ken-Ichi Kaida, Jun Shimizu, Ritsuko Hanajima, Toshihiro Hayashi, Yasuo Terao, Satomi Inomata-Terada, Masashi Hamada, Yuichiro Shirota, Akatsuki Kubota, Yoshikazu Ugawa, Kishin Koh, Yoshihisa Takiyama, Natsumi Ohsawa-Yoshida, Shoichi Ishiura, Ryo Yamasaki, Akira Tamaoka, Hiroshi Akiyama, Taisuke Otsuki, Akira Sano, Akio Ikeda, Jun Goto, Shinichi Morishita, Shoji Tsuji
Epilepsy is a common neurological disorder, and mutations in genes encoding ion channels or neurotransmitter receptors are frequent causes of monogenic forms of epilepsy. Here we show that abnormal expansions of TTTCA and TTTTA repeats in intron 4 of SAMD12 cause benign adult familial myoclonic epilepsy (BAFME). Single-molecule, real-time sequencing of BAC clones and nanopore sequencing of genomic DNA identified two repeat configurations in SAMD12. Intriguingly, in two families with a clinical diagnosis of BAFME in which no repeat expansions in SAMD12 were observed, we identified similar expansions of TTTCA and TTTTA repeats in introns of TNRC6A and RAPGEF2, indicating that expansions of the same repeat motifs are involved in the pathogenesis of BAFME regardless of the genes in which the expanded repeats are located...
March 5, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29495372/ultrahigh-density-linkage-map-construction-using-low-coverage-whole-genome-sequencing-of-a-doubled-haploid-population-case-study-of-torafugu-takifugu-rubripes
#16
Xiang Zhang, Misaki Mizukoshi, Hong Zhang, Engkong Tan, Yoji Igarashi, Yutaka Suzuki, Susumu Mitsuyama, Shigeharu Kinoshita, Kazuyoshi Saito, Shugo Watabe, Shuichi Asakawa
Next-generation sequencing enables genome-wide genotyping of a large population and further facilitates the construction of a genetic linkage map. Low-coverage whole-genome sequencing has been employed for genetic linkage map construction in several species. However, this strategy generally requires available high-quality reference genomes and/or designed inbred pedigree lines, which restrict the scope of application for non-model and unsequenced species. Here, using torafugu ( Takifugu rubripes ) as a test model, we propose a new strategy for ultrahigh-density genetic linkage map construction using low-coverage whole-genome sequencing of a haploid/doubled haploid (H/DH) population without above requirements...
February 26, 2018: Genes
https://www.readbyqxmd.com/read/29483431/-prolonged-survival-achieved-with-surgical-resection-and-multidisciplinary-therapy-for-acinar-cell-carcinoma-of-the-pancreas-with-liver-metastases
#17
Kyohei Kanematsu, Yuki Suematsu, Shunsuke Yamagishi, Miyuki Takahashi, Hiroyuki Saito, Mao Nakayama, Michiko Fukabori, Kazuhiko Wakabayashi, Yutaka Ito
We report 2 cases of prolonged survival achieved with surgical resection and multidisciplinary therapy for acinar cell carcinoma of the pancreas with liver metastases.Case 1: The patient was a 55-year-old woman.She presented with upper right abdominal pain and anemia.We diagnosed a tumor originating from the pancreas and multiple liver metastases.To avoid death caused by bleeding from the tumor, we performed pancreaticoduodenectomy and right-hemi hepatectomy, and a rapid diagnosis of acinar cell carcinoma of the pancreas was confirmed intraoperatively...
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29455535/antioxidative-nanoparticles-significantly-enhance-therapeutic-efficacy-of-an-antibacterial-therapy-against-listeria-monocytogenes-infection
#18
Yutaka Ikeda, Kazuhiro Shoji, Chitho P Feliciano, Shinji Saito, Yukio Nagasaki
Acute inflammatory conditions such as sepsis lead to fatal conditions, including multiple organ failure. Several treatments such as steroidal anti-inflammatory drugs are currently being investigated in order to decrease the blood cytokine level, which increases remarkably. However, any of these therapeutic treatments are not always reliable and effective; none have drastically improved survival rates, and some have mostly ended with failure. Reactive oxygen species (ROS) are signaling molecules responsible for the production of cytokines and chemokines that can mediate hyperactivation of the immune response called cytokine storm...
February 20, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29445505/the-japanese-clinical-practice-guidelines-for-management-of-sepsis-and-septic-shock-2016-j-sscg-2016
#19
Osamu Nishida, Hiroshi Ogura, Moritoki Egi, Seitaro Fujishima, Yoshiro Hayashi, Toshiaki Iba, Hitoshi Imaizumi, Shigeaki Inoue, Yasuyuki Kakihana, Joji Kotani, Shigeki Kushimoto, Yoshiki Masuda, Naoyuki Matsuda, Asako Matsushima, Taka-Aki Nakada, Satoshi Nakagawa, Shin Nunomiya, Tomohito Sadahiro, Nobuaki Shime, Tomoaki Yatabe, Yoshitaka Hara, Kei Hayashida, Yutaka Kondo, Yuka Sumi, Hideto Yasuda, Kazuyoshi Aoyama, Takeo Azuhata, Kent Doi, Matsuyuki Doi, Naoyuki Fujimura, Ryota Fuke, Tatsuma Fukuda, Koji Goto, Ryuichi Hasegawa, Satoru Hashimoto, Junji Hatakeyama, Mineji Hayakawa, Toru Hifumi, Naoki Higashibeppu, Katsuki Hirai, Tomoya Hirose, Kentaro Ide, Yasuo Kaizuka, Tomomichi Kan'o, Tatsuya Kawasaki, Hiromitsu Kuroda, Akihisa Matsuda, Shotaro Matsumoto, Masaharu Nagae, Mutsuo Onodera, Tetsu Ohnuma, Kiyohiro Oshima, Nobuyuki Saito, So Sakamoto, Masaaki Sakuraya, Mikio Sasano, Norio Sato, Atsushi Sawamura, Kentaro Shimizu, Kunihiro Shirai, Tetsuhiro Takei, Muneyuki Takeuchi, Kohei Takimoto, Takumi Taniguchi, Hiroomi Tatsumi, Ryosuke Tsuruta, Naoya Yama, Kazuma Yamakawa, Chizuru Yamashita, Kazuto Yamashita, Takeshi Yoshida, Hiroshi Tanaka, Shigeto Oda
Background and Purpose: The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 in Japanese. An English-language version of these guidelines was created based on the contents of the original Japanese-language version...
January 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29444864/lineage-specific-gene-acquisition-or-loss-is-involved-in-interspecific-hybrid-sterility-in-rice
#20
Yohei Koide, Atsushi Ogino, Takanori Yoshikawa, Yuki Kitashima, Nozomi Saito, Yoshitaka Kanaoka, Kazumitsu Onishi, Yoshihiro Yoshitake, Takuji Tsukiyama, Hiroki Saito, Masayoshi Teraishi, Yoshiyuki Yamagata, Aiko Uemura, Hiroki Takagi, Yoriko Hayashi, Tomoko Abe, Yoshimichi Fukuta, Yutaka Okumoto, Akira Kanazawa
Understanding the genetic basis of reproductive barriers between species has been a central issue in evolutionary biology. The S 1 locus in rice causes hybrid sterility and is a major reproductive barrier between two rice species, Oryza sativa and Oryza glaberrima The O. glaberrima -derived allele (denoted S1 g ) on the S 1 locus causes preferential abortion of gametes with its allelic alternative (denoted S1 s ) in S 1 g / S 1 s heterozygotes. Here, we used mutagenesis and screening of fertile hybrid plants to isolate a mutant with an allele, S 1 mut , which does not confer sterility in the S 1 mut / S 1 g and S 1 mut / S 1 s hybrids...
February 27, 2018: Proceedings of the National Academy of Sciences of the United States of America
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