keyword
https://read.qxmd.com/read/38639679/consensus-statements-on-the-current-landscape-of-artificial-intelligence-applications-in-endoscopy-addressing-roadblocks-and-advancing-artificial-intelligence-in-gastroenterology
#1
Sravanthi Parasa, Tyler Berzin, Cadman Leggett, Seth Gross, Alessandro Repici, Omer F Ahmad, Austin Chiang, Nayantara Coelho-Prabhu, Jonathan Cohen, Evelien Dekker, Rajesh N Keswani, Charles E Kahn, Cesare Hassan, Nicholas Petrick, Peter Mountney, Jonathan Ng, Michael Riegler, Yuichi Mori, Yutaka Saito, Shyam Thakkar, Irving Waxman, Michael Bradley Wallace, Prateek Sharma
BACKGROUND AND AIMS: The American Society for Gastrointestinal Endoscopy (ASGE) AI Task Force along with experts in endoscopy, technology space, regulatory authorities, and other medical subspecialties initiated a consensus process that analyzed the current literature, highlighted potential areas, and outlined the necessary research in artificial intelligence (AI) to allow a clearer understanding of AI as it pertains to endoscopy currently. METHODS: A modified Delphi process was used to develop these consensus statements...
April 16, 2024: Gastrointestinal Endoscopy
https://read.qxmd.com/read/38638518/perceiving-humanness-across-ages-neural-correlates-and-behavioral-patterns
#2
JOURNAL ARTICLE
Toshiki Saito, Rui Nouchi, Ryo Ishibashi, Kosuke Motoki, Yutaka Matsuzaki, Akiko Kobayashi, Motoaki Sugiura, Ryuta Kawashima
Humanness perception, which attributes fundamental and unique human characteristics to other objects or people, has significant consequences for people's interactions. Notably, the failure to perceive humanness in older adults can lead to prejudice. This study investigates the effect of a target's age on humanness perception in terms of two dimensions: agency (the ability to act and do) and experience (the ability to feel and sense). We also examined brain activity using a magnetic resonance imaging (MRI) scanner in order to understand the underlying neural mechanisms...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38636543/the-running-suture-with-clip-and-string-technique-after-colonic-endoscopic-submucosal-dissection
#3
JOURNAL ARTICLE
Mai Ego Makiguchi, Yutaka Saito
No abstract text is available yet for this article.
December 2024: Endoscopy
https://read.qxmd.com/read/38628101/risk-stratification-of-synchronous-gastric-cancers-including-alcohol-related-genetic-polymorphisms
#4
JOURNAL ARTICLE
Sho Asonuma, Waku Hatta, Tomoyuki Koike, Hideki Okata, Kaname Uno, Wataru Iwai, Masashi Saito, Makoto Yonechi, Daisuke Fukushi, Shoichi Kayaba, Ryosuke Kikuchi, Hirotaka Ito, Jun Fushiya, Ryuhei Maejima, Yasuhiko Abe, Masashi Kawamura, Junya Honda, Yutaka Kondo, Naohiro Dairaku, Shusuke Toda, Kenta Watanabe, Kiichi Takahashi, Hiroharu Echigo, Yasuaki Abe, Hiroyuki Endo, Tomoki Okata, Tatsuya Hoshi, Kenji Kinoshita, Madoka Kisoi, Tomohiro Nakamura, Naoki Nakaya, Katsunori Iijima, Atsushi Masamune
BACKGROUND AND AIM: We previously identified that ever-smoking and severe gastric atrophy in pepsinogen are risk factors for synchronous gastric cancers (SGCs). This study aimed to determine the association of alcohol drinking status or alcohol-related genetic polymorphism with SGCs and also stratify their risk. METHODS: This multi-center prospective cohort study included patients who underwent endoscopic submucosal dissection for the initial early gastric cancers at 22 institutions in Japan...
April 16, 2024: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38614865/spatial-and-single-cell-colocalisation-analysis-reveals-mdk-mediated-immunosuppressive-environment-with-regulatory-t-cells-in-colorectal-carcinogenesis
#5
JOURNAL ARTICLE
Masahiro Hashimoto, Yasuhiro Kojima, Takeharu Sakamoto, Yuki Ozato, Yusuke Nakano, Tadashi Abe, Kiyotaka Hosoda, Hideyuki Saito, Satoshi Higuchi, Yuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Tsuyoshi Hata, Satoshi Nagayama, Koichi Kagawa, Yasuhiro Goto, Mitsuaki Utou, Ayako Gamachi, Kiyomi Imamura, Yuta Kuze, Junko Zenkoh, Ayako Suzuki, Kazuki Takahashi, Atsushi Niida, Haruka Hirose, Shuto Hayashi, Jun Koseki, Satoshi Fukuchi, Kazunari Murakami, Tomoharu Yoshizumi, Kenji Kadomatsu, Taro Tobo, Yoshinao Oda, Mamoru Uemura, Hidetoshi Eguchi, Yuichiro Doki, Masaki Mori, Masanobu Oshima, Tatsuhiro Shibata, Yutaka Suzuki, Teppei Shimamura, Koshi Mimori
BACKGROUND: Cell-cell interaction factors that facilitate the progression of adenoma to sporadic colorectal cancer (CRC) remain unclear, thereby hindering patient survival. METHODS: We performed spatial transcriptomics on five early CRC cases, which included adenoma and carcinoma, and one advanced CRC. To elucidate cell-cell interactions within the tumour microenvironment (TME), we investigated the colocalisation network at single-cell resolution using a deep generative model for colocalisation analysis, combined with a single-cell transcriptome, and assessed the clinical significance in CRC patients...
April 9, 2024: EBioMedicine
https://read.qxmd.com/read/38596161/penetrating-cardiac-injury-caused-by-multiple-rib-fractures-following-high-energy-trauma-usefulness-of-the-exploratory-video-assisted-thoracoscopic-surgery
#6
Keisuke Tetsumoto, Masakazu Takayama, Tadaaki Koyama, Hidenao Kayawake, Masao Saito, Ken Nakamura, Yutaka Takahashi, Hiroshi Hamakawa
BACKGROUND: Penetrating cardiac injuries are usually fatal and associated with poor survival rates. CASE PRESENTATION: A 69-year-old man was injured in a motor vehicle accident and suffered from left hemothorax and multiple rib fractures near the heart. A comprehensive assessment raised suspicions of lacerated pericardium and myocardial injury. Consequently, a thoracoscopy was performed 9 h after injury. A penetrating cardiac injury was detected and surgically treated via video-assisted thoracoscopic surgery...
2024: Acute Medicine & Surgery
https://read.qxmd.com/read/38593994/the-case-of-infected-intra-abdominal-hematoma-complicating-endoscopic-ultrasound-guided-tissue-acquisition
#7
JOURNAL ARTICLE
Daiki Agarie, Susumu Hijioka, Yoshikuni Nagashio, Yuta Maruki, Mark Chatto, Yutaka Saito, Takuji Okusaka
No abstract text is available yet for this article.
December 2024: Endoscopy
https://read.qxmd.com/read/38574990/use-of-data-independent-acquisition-mass-spectrometry-to-identify-an-objective-serum-indicator-of-the-need-for-osteoporotic-therapeutic-intervention
#8
JOURNAL ARTICLE
Yusuke Nakai, Ken Kumagai, Yoko Ino, Tomoko Akiyama, Kayano Moriyama, Yuriko Takeda, Kenji Egashira, Takashi Ohira, Akihide Ryo, Tomoyuki Saito, Yutaka Inaba, Hisashi Hirano, Yayoi Kimura
Osteoporosis is characterized by weakened bone microstructure and loss of bone mass. Current diagnostic criteria for osteoporosis are based on the T-score, which is a measure of bone mineral density. However, osteoporotic fragility fractures can occur regardless of the T-score, underscoring the need for additional criteria for the early detection of patients at fracture risk. To identify indicators of reduced bone strength, we performed serum proteomic analysis using data-independent acquisition mass spectrometry with serum samples from two patient groups, one with osteoporosis but no fractures and the other with osteopenia and fragility fractures...
April 2, 2024: Journal of Proteomics
https://read.qxmd.com/read/38558228/intractable-nocardial-mycetoma-with-possible-colonisation-by-candida-species
#9
JOURNAL ARTICLE
Ayano Sumioki, Kanami Saito, Haruto Nishida, Akira Nishizono, Yuji Miyamoto, Norihisa Ishii, Masataro Hiruma, Kazutoshi Shibuya, Takashi Yaguchi, Yutaka Hatano
A Japanese male in his 30s with no underlying medical condition presented with painless nodules after being bitten by a dog during a stay in Bali, Indonesia, 7 years earlier. He was referred to our department with multiple ulcers, nodules, and masses on the right leg. The final diagnosis was mycetoma caused by Nocardia vulneris, which may have been exacerbated by colonization of Candida parapsilosis and C. tropicalis as these yeasts were isolated by culture from the tissue. Treatment with minocycline hydrochloride and sulfamethoxazole trimethoprim showed partial efficacy, but the addition of posaconazole achieved significant efficacy...
April 1, 2024: Journal of Dermatology
https://read.qxmd.com/read/38556472/international-digestive-endoscopy-network-consensus-on-the-management-of-antithrombotic-agents-in-patients-undergoing-gastrointestinal-endoscopy
#10
REVIEW
Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
Antithrombotic agents, including antiplatelet agents and anticoagulants, are widely used in Korea because of the increasing incidence of cardiocerebrovascular disease and the aging population. The management of patients using antithrombotic agents during endoscopic procedures is an important clinical challenge. The clinical practice guidelines for this issue, developed by the Korean Society of Gastrointestinal Endoscopy, were published in 2020. However, new evidence on the use of dual antiplatelet therapy and direct anticoagulant management has emerged, and revised guidelines have been issued in the United States and Europe...
March 2024: Clinical Endoscopy
https://read.qxmd.com/read/38548963/primary-analysis-of-a-prospective-cohort-study-of-japanese-patients-with-plasma-cell-neoplasms-in-the-novel-drug-era-2016-2021
#11
JOURNAL ARTICLE
Hirohiko Shibayama, Mitsuhiro Itagaki, Hiroshi Handa, Akihiro Yokoyama, Akio Saito, Satoru Kosugi, Shuichi Ota, Makoto Yoshimitsu, Yasuhiro Tanaka, Shingo Kurahashi, Shin-Ichi Fuchida, Masaki Iino, Takayuki Shimizu, Yukiyoshi Moriuchi, Kohtaro Toyama, Kinuko Mitani, Yutaka Tsukune, Akiko Kada, Hideto Tamura, Masahiro Abe, Hiromi Iwasaki, Junya Kuroda, Hiroyuki Takamatsu, Kazutaka Sunami, Masahiro Kizaki, Tadao Ishida, Toshiki Saito, Itaru Matsumura, Koichi Akashi, Shinsuke Iida
The emergence of novel drugs has significantly improved outcomes of patients with plasma cell neoplasms (PCN). The Japanese Society of Hematology conducted a prospective observational study in newly diagnosed PCN patients between 2016 and 2021. The analysis focused on 1385 patients diagnosed with symptomatic PCN between 2016 and 2018. The primary endpoint was the 3-year overall survival (OS) rate among patients requiring treatment (n = 1284), which was 70.0% (95%CI 67.4-72.6%). Approximately 94% of these patients received novel drugs as frontline therapy...
March 29, 2024: International Journal of Hematology
https://read.qxmd.com/read/38475964/identification-of-gravity-responsive-serum-proteins-in-spaceflight-mice-using-a-quantitative-proteomic-approach-with-data-independent-acquisition-mass-spectrometry
#12
JOURNAL ARTICLE
Yayoi Kimura, Yusuke Nakai, Yoko Ino, Tomoko Akiyama, Kayano Moriyama, Takashi Ohira, Tomoyuki Saito, Yutaka Inaba, Ken Kumagai, Akihide Ryo, Hisashi Hirano
Physical inactivity associated with gravity unloading, such as microgravity during spaceflight and hindlimb unloading (HU), can cause various physiological changes. In this study, we attempted to identify serum proteins whose levels fluctuated in response to gravity unloading. First, we quantitatively assessed changes in the serum proteome profiles of spaceflight mice using mass spectrometry with data-independent acquisition. The serum levels of several proteins involved in the responses to estrogen and glucocorticoid, blood vessel maturation, osteoblast differentiation, and ossification were changed by microgravity exposure...
March 12, 2024: Proteomics
https://read.qxmd.com/read/38464977/incidence-and-factors-associated-with-stent-dysfunction-and-pancreatitis-after-gastroduodenal-stenting-for-malignant-gastric-outlet-obstruction
#13
JOURNAL ARTICLE
Daiki Yamashige, Susumu Hijioka, Yoshikuni Nagashio, Yuta Maruki, Soma Fukuda, Shin Yagi, Kohei Okamoto, Hidenobu Hara, Yuya Hagiwara, Daiki Agarie, Tetsuro Takasaki, Mark Chatto, Akihiro Ohba, Shunsuke Kondo, Chigusa Morizane, Hideki Ueno, Miyuki Sone, Yutaka Saito, Takuji Okusaka
Background and study aims Endoscopic gastroduodenal stent (GDS) deployment is currently a standard treatment for malignant gastric outlet obstruction (mGOO) in patients with limited life expectancy; however, stent dysfunction (SD) and complicated pancreatitis often occur after GDS deployment. We investigated incidence and contributing factors of SD and complicated pancreatitis. Patients and methods We retrospectively reviewed 203 patients who underwent initial GDS deployment for palliation of mGOO symptoms between October 2017 and July 2022, including 109 who underwent GDS deployment across the duodenal papilla (sub-cohort)...
March 2024: Endoscopy International Open
https://read.qxmd.com/read/38462466/-endoscopic-diagnosis-and-treatment-of-colorectal-tumors-and-future-prospects
#14
JOURNAL ARTICLE
Naoya Toyoshima, Yutaka Saito
No abstract text is available yet for this article.
2024: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://read.qxmd.com/read/38447662/top-tips-for-performing-high-quality-optical-zoom-chromocolonoscopy
#15
JOURNAL ARTICLE
Yutaka Saito
No abstract text is available yet for this article.
March 4, 2024: Gastrointestinal Endoscopy
https://read.qxmd.com/read/38433322/proportions-and-characteristics-of-interval-cancer-in-annual-fecal-immunochemical-test-screening-and-postcolonoscopy-colorectal-cancer-results-from-a-japanese-multicenter-prospective-study-using-questionnaires-the-c-detect-study
#16
JOURNAL ARTICLE
Masau Sekiguchi, Yoshihiro Kishida, Hiroaki Ikematsu, Maki Konno, Yasuhiko Mizuguchi, Kinichi Hotta, Kenichiro Imai, Sayo Ito, Kazunori Takada, Akio Shiomi, Hirofumi Yasui, Shunsuke Tsukamoto, Hidekazu Hirano, Nozomu Kobayashi, Yutaka Saito, Atsushi Inaba, Kensuke Shinmura, Jun Konishi, Heita Ozawa, Shin Fujita, Yoshitaka Murakami, Takahisa Matsuda
OBJECTIVES: There are several types of colorectal cancer (CRC) according to the detection methods and intervals, including interval CRC (iCRC) and postcolonoscopy CRC (PCCRC). We aimed to examine their proportions and characteristics. METHODS: We conducted a multicenter prospective study using questionnaires in Japan ("C-DETECT study"), in which differences in CRC characteristics according to detection methods and intervals were examined from consecutive adult patients...
March 3, 2024: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://read.qxmd.com/read/38420152/interactive-training-with-a-novel-simulation-model-for-upper-gastrointestinal-endoscopic-hemostasis-improves-trainee-technique-and-confidence
#17
JOURNAL ARTICLE
Takeshi Kanno, Yutaro Arata, Eric Greenwald, Paul Moayyedi, Suguo Suzuki, Yutaka Hatayama, Masahiro Saito, Xiaoyi Jin, Waku Hatta, Kaname Uno, Naoki Asano, Akira Imatani, Yutaka Kagaya, Tomoyuki Koike, Atsushi Masamune
Background and study aims Endoscopic hemostasis is a life-saving procedure for gastrointestinal bleeding; however, training for it is often performed on real patients and during urgent situations that put patients at risk. Reports of simulation-based training models for endoscopic hemostasis are scarce. Herein, we developed a novel simulator called "Medical Rising STAR-Ulcer type" to practice endoscopic hemostasis with hemoclips and coagulation graspers. This study aimed to evaluate the reproducibility of the clinical difficulty of this model and the effectiveness of simulation-based training for clipping hemostasis...
February 2024: Endoscopy International Open
https://read.qxmd.com/read/38389505/impacts-of-febuxostat-on-cerebral-and-cardiovascular-events-in-elderly-patients-with-hyperuricemia-post-hoc-analysis-of-a-randomized-controlled-trial
#18
JOURNAL ARTICLE
Masahiro Sugawara, Sunao Kojima, Ichiro Hisatome, Kunihiko Matsui, Kazuaki Uchiyama, Naoto Yokota, Eiichi Tokutake, Yutaka Wakasa, Shinya Hiramitsu, Masako Waki, Hideaki Jinnouchi, Hirokazu Kakuda, Takahiro Hayashi, Naoki Kawai, Hisao Mori, Kenichi Tsujita, Yusuke Ohya, Kazuo Kimura, Yoshihiko Saito, Hisao Ogawa
A recent meta-analysis found no benefit of uric acid-lowering therapy including febuxostat on death, cardiovascular events, or renal impairment. However, there may be populations that benefit from febuxostat in reducing mortality and cerebral and cardiovascular events. The aim of the present study was to examine the clinical benefit of febuxostat in elderly patients stratified by age using Febuxostat for Cerebral and CaRdiorenovascular Events PrEvEntion StuDy (FREED) data. FREED was a randomized study involving patients aged 65 years or older with hyperuricemia and risk factors for cerebral, cardiovascular, or renal diseases...
February 23, 2024: Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38345215/treatment-decision-for-locally-resected-t1-colorectal-carcinoma-verification-of-the-japanese-guideline-criteria-for-additional-surgery-based-on-long-term-clinical-outcomes
#19
JOURNAL ARTICLE
Shiro Oka, Shinji Tanaka, Yoshiki Kajiwara, Shoichi Saito, Yosuke Fukunaga, Manabu Takamatsu, Hiroshi Kawachi, Kinich Hotta, Hiroaki Ikematsu, Motohiro Kojima, Yutaka Saito, Masayoshi Yamada, Yukihide Kanemitsu, Shigeki Sekine, Shinji Nagata, Kazutaka Yamada, Nozomu Kobayashi, Soichiro Ishihara, Yusuke Saitoh, Kenji Matsuda, Kazutomo Togashi, Koji Komori, Megumi Ishiguro, Toshio Kuwai, Takashi Okuyama, Akihiro Ohuchi, Shinobu Ohnuma, Kazuhiro Sakamoto, Tamotsu Sugai, Kenji Katsumata, Hiro-O Matsushita, Hiro-O Yamano, Hirotsugu Eda, Toshio Uraoka, Naohiko Akimoto, Hirotoshi Kobayashi, Kenichi Sugihara, Hideki Ueno
OBJECTIVES: To verify the value of the pathological criteria for additional treatment in locally resected pT1 colorectal carcinoma (CRC) which have been used in the Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines since 2009. METHODS: We enrolled 4719 patients with pT1 CRC treated at 27 institutions between July 2009 and December 2016 (1259 patients with local resection alone [Group A], 1508 patients with additional surgery after local resection [Group B], and 1952 patients with surgery alone [Group C])...
February 12, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38331727/efficacy-of-endoscopic-submucosal-resection-with-a-ligation-device-for-small-rectal-neuroendocrine-tumor-study-protocol-of-a-multicenter-open-label-randomized-control-trial-bandit-trial
#20
JOURNAL ARTICLE
Kazunori Takada, Kenichiro Imai, Takanori Yamada, Ken Ohata, Takashi Kanesaka, Yasuaki Nagami, Yasushi Yamasaki, Hideki Kobara, Yasuhiro Inokuchi, Akiko Chino, Shinjiro Yamaguchi, Hisatomo Ikehara, Takuji Kawamura, Yohei Yabuuchi, Yasuhiko Mizuguchi, Hiroaki Ikematsu, Chizu Yokoi, Santa Hattori, Kazuya Ohno, Yashiro Yoshizawa, Masakatsu Fukuzawa, Yosuke Tsuji, Jun Konishi, Takeshi Yamamura, Satoshi Osawa, Shiro Oka, Takuto Hikichi, Kazutomo Togashi, Kingo Hirasawa, Toshio Uraoka, Yoji Takeuchi, Hideyuki Chiba, Yoriaki Komeda, Hisashi Doyama, Mari S Oba, Yutaka Saito
BACKGROUND: Endoscopic resection is widely accepted as a local treatment for rectal neuroendocrine tumors sized ≤ 10 mm. However, there is no consensus on the best method for the endoscopic resection of rectal neuroendocrine tumors. As a simplified endoscopic procedure, endoscopic submucosal resection with a ligation device (ESMR-L) indicates a histologically complete resection rate comparable to that of endoscopic submucosal dissection (ESD). We hypothesized that ESMR-L than ESD would be preferred for rectal neuroendocrine tumors...
February 8, 2024: BMC Gastroenterology
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