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Osteoarthritis clinic

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https://www.readbyqxmd.com/read/29452296/development-and-persistence-of-suspected-neuropathic-pain-after-total-knee-arthroplasty-in-individuals-with-osteoarthritis
#1
Matthew Fitzsimmons, Eloise Carr, Linda Woodhouse, Geoff P Bostick
BACKGROUND: Despite the effectiveness of total knee arthroplasty (TKA) for osteoarthritis (OA), up to 20% will report knee pain 1-year after surgery. One possible reason is the development of neuropathic pain before or after TKA. OBJECTIVE: To longitudinally describe suspected neuropathic pain in patients pre- and post-TKA and to explore relationships between pre-TKA suspected neuropathic pain and post-TKA outcomes. DESIGN: Prospective observational study...
February 13, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29451138/detection-of-repair-of-the-zone-of-calcified-cartilage-with-osteoarthritis-through-mesenchymal-stem-cells-by-ultrashort-echo-time-magnetic-resonance-imaging
#2
REVIEW
Quan Zhou, Shao-Lin Li, Ya-Jun Ma, Vicki de Tal, Wei Li, Ying-Hua Zhao
Objective: Currently, magnetic resonance imaging (MRI) is the most commonly used imaging modality for observing the growth and development of mesenchymal stem cells (MSCs) after in vivo transplantation to treat osteoarthritis (OA). However, it is a challenge to accurately monitor the treatment effects of MSCs in the zone of calcified cartilage (ZCC) with OA. This is especially true in the physiological and biochemical views that are not accurately detected by MRI contrast agents. In contrast, ultrashort time echo (UTE) MRI has been shown to be sensitive to the presence of the ZCC, creating the potential for more effectively observing the repair of the ZCC in OA by MSCs...
February 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29450666/recent-advances-in-hyaluronic-acid-based-therapy-for-osteoarthritis
#3
REVIEW
Steven Bowman, Mohamed E Awad, Mark W Hamrick, Monte Hunter, Sadanand Fulzele
Osteoarthritis is a debilitating disease that has increased in prevalence across the world due to the aging population. Currently, physicians use a plethora of treatment strategies to try and slow down the progression of the disease, but none have been shown to ubiquitously treat and cure the disease. One of the strategies uses the high molecular weight molecule hyaluronic acid as either an injectable or oral supplement for treatment. Hyaluronic acid (HA) is a relatively new treatment that has shown varied results through several clinical trials...
February 16, 2018: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/29450208/clinical-outcomes-after-microfracture-of-the-knee-midterm-follow-up
#4
Alexander E Weber, Philip H Locker, Erik N Mayer, Gregory L Cvetanovich, Annemarie K Tilton, Brandon J Erickson, Adam B Yanke, Brian J Cole
Background: Microfracture is a single-stage arthroscopic procedure used to treat small- and medium-sized cartilage defects, the clinical results of which have been mixed to date. Purpose: To retrospectively evaluate prospectively collected patient-reported outcomes (PROs) after microfracture as well as to determine patient-related and defect-related factors associated with clinical outcomes and which factors predict the need for additional surgery. Study Design: Case-control study; Level of evidence, 3...
February 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29449014/periarticular-bone-predicts-knee-osteoarthritis-progression-data-from-the-osteoarthritis-initiative
#5
Grace H Lo, Erika Schneider, Jeffrey B Driban, Lori Lyn Price, David J Hunter, Charles B Eaton, Marc C Hochberg, Rebecca D Jackson, C Kent Kwoh, Michael C Nevitt, John A Lynch, Timothy E McAlindon
OBJECTIVE: Osteoarthritis (OA) is a disease with a substantial public health burden. Quantitative assessments of periarticular bone may be a biomarker capable of monitoring early disease progression. The purpose of this study was to evaluate whether measures of periarticular bone associate with longitudinal structural progression. METHODS: We conducted a 12-18 months longitudinal study using the Osteoarthritis Initiative (OAI). Participants received knee dual-energy x-ray absorptiometry (DXA), trabecular magnetic resonance (MR) imaging, and x-rays...
January 31, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29449003/upper-partial-fibulectomy-improves-knee-biomechanics-and-function-and-decreases-knee-pain-of-osteoarthritis-a-pilot-and-biomechanical-study
#6
Yong Nie, Jun Ma, ZeYu Huang, Bin Xu, Shuo Tang, Bin Shen, Virginia Byers Kraus, FuXing Pei
To investigate the change in clinical outcomes and biomechanical properties of the knee in response to upper partial fibulectomy. Sixteen patients with medial compartment knee osteoarthritis (KOA) underwent upper partial fibulectomy. Visual analog scale (VAS) pain, the hospital for special surgery knee score (HSS), hip-knee-ankle (HKA) angle (measured in the frontal plane), and flexion/extension range of motion of the knee were assessed before and up to 6 months after surgery. Patients were evaluated for gait parameters and overall peak knee adduction moment (KAM)...
December 13, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29448817/treating-severe-knee-osteoarthritis-with-combination-of-intra-osseous-and-intra-articular-infiltrations-of-platelet-rich-plasma-an-observational-study
#7
Mikel Sánchez, Diego Delgado, Orlando Pompei, Juan Carlos Pérez, Pello Sánchez, Ane Garate, Ane Miren Bilbao, Nicolás Fiz, Sabino Padilla
Objective Assessing the therapeutic effects of a combination of intra-articular and intra-osseous infiltrations of platelet-rich plasma (PRP) to treat severe knee osteoarthritis (KOA) using intra-articular injections of PRP as the control group. Design In this observational study, 60 patients suffering from severe KOA were treated with intra-articular infiltrations of PRP (IA group) or with a combination of intra-osseous and intra-articular infiltrations of PRP (IO group). Both groups were matched for sex, age, body mass index, and radiographic severity (III and IV degree according to Ahlbäck scale)...
February 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29446485/effects-of-glucosamine-supplements-on-painful-temporomandibular-joint-osteoarthritis-a-systematic-review
#8
REVIEW
Gilberto Melo, Elora Casett, Juliana Stuginski-Barbosa, Eliete Neves da Silva Guerra, Daniel Araujo Fernandes, André Luís Porporatti, Carlos Flores-Mir, Graziela De Luca Canto
OBJECTIVE: To systematically review the literature for studies that assessed the effects of glucosamine supplements (GS) on pain and maximum mouth opening (MMO) restriction compared to other therapies, placebo, or no intervention on painful temporomandibular joint osteoarthritis (TMJ OA). METHODS: Randomized controlled trials were selected in a two-phase process. Seven electronic databases, in addition to three grey literature databases, were searched. Risk of bias was assessed using the Cochrane Collaboration's tool for assessing risk of bias in randomized trials...
February 15, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29446121/atrophy-of-hip-abductor-muscles-is-related-to-clinical-severity-in-a-hip-osteoarthritis-population
#9
Anita Zacharias, Rodney A Green, Adam Semciw, Daniel J English, Theo Kapakoulakis, Tania Pizzari
INTRODUCTION: Osteoarthritis mainly affects weight-bearing joints such as the hip and knee and is the most common form of arthritis. Greater muscle atrophy with fatty infiltration of gluteal muscles and decreased hip abduction strength has previously been identified with increasing severity of radiological hip OA. However, it is well documented that radiographic findings of OA do not always correlate with clinical severity. The aim of this secondary analysis was to examine whether atrophy and strength of gluteus maximus (GMax), medius (GMed), minimus (GMin), and tensor fascia lata (TFL) is associated with the clinical severity of OA...
February 15, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29444664/the-knitting-community-based-trial-for-older-women-with-osteoarthritis-of-the-hands-design-and-rationale-of-a-randomized-controlled-trial
#10
Paulette Guitard, Lucie Brosseau, George A Wells, Nicole Paquet, Gail Paterson, Karine Toupin-April, Sabrina Cavallo, Sibel Z Aydin, Guillaume Léonard, Gino De Angelis
BACKGROUND: The prevalence of hand osteoarthritis (HOA) has been reported to be higher amongst women over 50 years old (66%) compared to men of the same age (34%). Although exercise therapy has been shown effective in reducing symptoms and disability associated with HOA, adherence to treatment programs remains low. The primary objective of this RCT is to examine the effectiveness of a 12-week knitting program for morning stiffness (primary outcome) and pain relief (secondary outcome) 2 h post-wakening in females (aged 50 to 85 years old) with mild to moderate hand osteoarthritis (HOA)...
February 14, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29443030/treatment-of-ankle-osteoarthritis-with-total-ankle-replacement-through-a-lateral-transfibular-approach
#11
Federico G Usuelli, Riccardo D'Ambrosi, Luigi Manzi, Camilla Maccario, Cristian Indino
Total ankle replacement (TAR) is a valid option for the treatment of ankle osteoarthritis. The traditional surgical approach for TAR is the anterior approach. Recently, the lateral transfibular approach to the ankle has gained popularity since a new TAR implant was designed to be performed via this approach that results in an ideal visualization of the center of rotation of the ankle and curved resections that allow for sparing bone cuts. The aim of the present paper is to present our preoperative, operative, and postoperative protocols for the treatment of the osteoarthritis of the ankle with TAR via lateral approach...
January 24, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29441992/microrna-320a-protects-against-osteoarthritis-cartilage-degeneration-by-regulating-the-expressions-of-bmi-1-and-runx2-in-chondrocytes
#12
Hao Peng, Du Liang, Baolin Li, Chizhang Liang, Wenhua Huang, Haibin Lin
Osteoarthritis (OA) is one of the most common chronic degenerative diseases characterized by deterioration of articular cartilage. Many studies have demonstrated the role of microRNAs (miRNAs) in OA, but the role of miR-320a in OA remains elusive. The aim of this study was to identify the protective role of miR-320a in OA cartilage degeneration by regulating the expression of BMI-1 and RUNX-2 proteins in chondrocytes. Normal and OA chondrocytes obtained from patients were cultured in vitro. The chondrocytes (both normal and OA) were transfected with miR-320a inhibitor to investigate the effects of miR-320a on chondrocyte proliferation, and to identify the miR-320a target proteins...
April 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29440159/multicentre-study-on-capsular-closure-versus-non-capsular-closure-during-hip-arthroscopy-in-danish-patients-with-femoroacetabular-impingement-fai-protocol-for-a-randomised-controlled-trial
#13
Christian Dippmann, Otto Kraemer, Bent Lund, Michael Krogsgaard, Per Hölmich, Martin Lind, Karen Briggs, Marc Philippon, Bjarne Mygind-Klavsen
INTRODUCTION: Hip arthroscopy has become a standard procedure in the treatment of hip joint pain not related to osteoarthritis or dysplasia in the young and active patient. There has been increasing focus on the contribution of the hip capsule to function and on stability following hip arthroscopy. It has been suggested that capsular closure after hip arthroscopy may prevent microinstability and macroinstability of the hip joint and reduce revision rate. However, it remains unknown whether capsular closure should be performed as a standard procedure when performing hip arthroscopies, especially in patients without additional risk factors for instability such as hypermobility or dysplasia of the hip...
February 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29439307/ultrasound-combined-transcutaneous-electrical-nerve-stimulation-ultratens-versus-phonophoresis-of-piroxicam-php-in-symptomatic-knee-osteoarthritis-a-randomized-double-blind-controlled-trial
#14
Jariya Boonhong, Phitsanu Suntornpiyapan
BACKGROUND: Ultrasound combined with transcutaneous electrical nerve stimulation (UltraTENS) and phonophoresis of piroxicam (PhP) are combined modality therapy that frequently used in musculoskeletal pain including knee osteoarthritis (OA). But it is lack of a good clinical trial to prove and compare their effects. OBJECTIVE: To compare the effects of UltraTENS with PhP on mild to moderate degree of symptomatic knee OA. METHODS: Sixty-one patients (55 women), mean age of 63...
February 2, 2018: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29439295/transcriptional-profiling-of-synovial-macrophages-using-minimally-invasive-ultrasound-guided-synovial-biopsies-in-rheumatoid-arthritis
#15
Arthur M Mandelin, Philip J Homan, Alexander M Shaffer, Carla M Cuda, Salina T Dominguez, Emily Bacalao, Mary Carns, Monique Hinchcliff, Jungwha Lee, Kathleen Aren, Anjali Thakrar, Anna B Montgomery, S Louis Bridges, Joan M Bathon, John P Atkinson, David A Fox, Eric L Matteson, Christopher D Buckley, Costantino Pitzalis, Deborah Parks, Laura B Hughes, Laura Geraldino-Pardilla, Robert Ike, Kristine Phillips, Kerry Wright, Andrew Filer, Stephen Kelly, Eric M Ruderman, Vince Morgan, Hiam Abdala-Valencia, Alexander V Misharin, G Scott Budinger, Elizabeth T Bartom, Richard M Pope, Harris Perlman, Deborah R Winter
OBJECTIVE: Currently, there are no reliable biomarkers for predicting therapeutic response in patients with rheumatoid arthritis (RA). The synovium may unlock critical information for determining efficacy as reduction in numbers of sublining synovial macrophages remains the most reproducible biomarker. Thus, a clinically actionable method for collection of synovial tissue, which can be analyzed using high-throughput strategies, must become a reality. METHODS: Rheumatologists at six United States academic sites were trained in minimally invasive ultrasound-guided synovial tissue biopsy...
February 13, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29435594/-periacetabular-osteotomy-what-influence-does-age-have-on-patient-relevant-results-a-prospective-5%C3%A2-year-investigation
#16
L Franken, F Thielemann, A Postler, S Blum, A Hartmann, K-P Günther, J Goronzy
INTRODUCTION: Periacetabular osteotomy (PAO) is an effective procedure in treatment of symptomatic hip dysplasia. To achieve a good outcome a strict patient selection has to be applied. The aim of this study was to evaluate the influence of patient age at surgery on clinical outcome. METHODS: In a prospective study 86 patients (106 hips) underwent clinical and radiographic follow-up at a mean time of 5 years (2.5-8.5 years) after PAO. Patient-related outcome measurements (PROMs: EQ-5D, WOMAC, OHS, GTO) were applied preoperatively as well as postoperatively and the deformity correction as well as development of osteoarthritis were evaluated...
February 12, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29434185/glucagon-like-peptide-1-receptor-regulates-endoplasmic-reticulum-stress-induced-apoptosis-and-the-associated-inflammatory-response-in-chondrocytes-and-the-progression-of-osteoarthritis-in-rat
#17
Jian Chen, Jun-Jun Xie, Ke-Si Shi, Yun-Tao Gu, Cong-Cong Wu, Jun Xuan, Yue Ren, Long Chen, Yao-Sen Wu, Xiao-Lei Zhang, Jian Xiao, De-Zhong Wang, Xiang-Yang Wang
Treatments for osteoarthritis (OA) are designed to restore chondrocyte function and inhibit cell apoptosis. Previous studies have shown that activation of the glucagon-like peptide-1 receptor (GLP-1R) leads to anti-inflammatory and anti-apoptotic effects. However, the role of GLP-1R in the pathological process of OA is unclear. In present work, we aimed to demonstrate the potential effect of GLP-1R on chondrocytes and elucidate its underlying mechanisms. We found that activation of GLP-1R with liraglutide could protect chondrocytes against endoplasmic reticulum stress and apoptosis induced by interleukin (IL)-1β or triglycerides (TGs)...
February 12, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29433980/fatty-infiltration-and-muscle-atrophy-of-the-rotator-cuff-in-stemless-total-shoulder-arthroplasty-a-prospective-cohort-study
#18
Arkan S Sayed-Noor, Raymond Pollock, Bassem T Elhassan, Bakir Kadum
BACKGROUND: The influence of preoperative rotator cuff fatty infiltration (FI) and muscle atrophy (MA) on the postoperative outcome of total shoulder arthroplasty (TSA) has only rarely been investigated and reported in the literature. We hypothesized that more FI and MA would be associated with a worse postoperative functional outcome. METHODS: This prospective cohort study included 63 patients (31 female and 32 male patients; mean age, 71 years [range, 53-89 years; standard deviation, 7 years]) with primary osteoarthritis of the shoulder operated on with anatomic stemless TSA...
February 9, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29429373/long-term-clinical-and-mri-results-of-matrix-assisted-autologous-chondrocyte-implantation-for-articular-cartilage-defects-of-the-knee
#19
Peter Cornelius Kreuz, Richard Horst Kalkreuth, Philipp Niemeyer, Markus Uhl, Christoph Erggelet
Objective To evaluate the long-term clinical and radiological outcome of matrix-assisted autologous chondrocyte implantation (mACI) for articular cartilage defects in the knee joint. Design Clinical evaluation was assessed in 21 patients with full-thickness cartilage defects, International Cartilage Repair Society (ICRS) grade IV. Clinical scoring was performed preoperatively and 12 years after transplantation using the International Knee Documentation Committee (IKDC) score, the Lysholm score, the Knee injury and Osteoarthritis Outcome Score (KOOS), and the Noyes sports activity rating scale...
February 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29428418/results-of-surgical-treatment-of-acromioclavicular-dislocations-type-iii-using-modified-weaver-dunn-technique
#20
S López-Alameda, T Fernández-Santás, A García-Villanueva, D Varillas-Delgado, F Garcia de Lucas
OBJECTIVE: To evaluate the clinical and radiological results of the surgical treatment of type III acromioclavicular dislocations using the Weaver-Dunn technique in the delayed phase. MATERIAL AND METHOD: A non-randomised controlled retrospective observational study of 38 patients operated between January 2006 and December 2014. We excluded 10 patients due to death or non-localisation. We collected demographic data, time to intervention, complications, analysing the Visual Analog Scale, DASH and Oxford Shoulder Score and the updated radiological result...
February 7, 2018: Revista Española de Cirugía Ortopédica y Traumatología
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