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https://www.readbyqxmd.com/read/29691832/clinical-trials-and-management-of-osteochondral-lesions
#1
Carlos A Vilela, Alain da Silva Morais, Sandra Pina, J Miguel Oliveira, Vitor M Correlo, Rui L Reis, João Espregueira-Mendes
Osteochondral lesions are frequent and important causes of pain and disability. These lesions are induced by traumatic injuries or by diseases that affect both the cartilage surface and the subchondral bone. Due to the limited cartilage ability to regenerate and self-repair, these lesions tend to gradually worsen and progress towards osteoarthritis. The clinical, social, and economic impact of the osteochondral lesions is impressive and although therapeutic alternatives are under discussion, a consensus is not yet been achieved...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29691831/osteochondral-tissue-engineering-translational-research-and-turning-research-into-products
#2
Victoria Spencer, Erica Illescas, Lorenzo Maltes, Hyun Kim, Vinayak Sathe, Syam Nukavarapu
Osteochondral (OC) defect repair is a significant clinical challenge. Osteoarthritis results in articular cartilage/subchondral bone tissue degeneration and tissue loss, which in the long run results in cartilage/ostecochondral defect formation. OC defects are commonly approached with autografts and allografts, and both these options have found limitations. Alternatively, tissue engineered strategies with biodegradable scaffolds with and without cells and growth factors have been developed. In order to approach regeneration of complex tissues such as osteochondral, advanced tissue engineered grafts including biphasic, triphasic, and gradient configurations are considered...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29691818/nanomaterials-nanocomposites-for-osteochondral-tissue
#3
Ohan S Manoukian, Connor Dieck, Taylor Milne, Caroline N Dealy, Swetha Rudraiah, Sangamesh G Kumbar
For many years, the avascular nature of cartilage tissue has posed a clinical challenge for replacement, repair, and reconstruction of damaged cartilage within the human body. Injuries to cartilage and osteochondral tissues can be due to osteoarthritis, sports, aggressive cancers, and repetitive stresses and inflammation on wearing tissue. Due to its limited capacity for regeneration or repair, there is a need for suitable material systems which can recapitulate the function of the native osteochondral tissue physically, mechanically, histologically, and biologically...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29691281/loss-of-fgfr1-in-chondrocytes-inhibits-osteoarthritis-through-promoting-autophagic-activity-in-temporomandibular-joint
#4
Zuqiang Wang, Junlan Huang, Siru Zhou, Fengtao Luo, Qiaoyan Tan, Xianding Sun, Zhenhong Ni, Hangang Chen, Xiaolan Du, Yangli Xie, Lin Chen
Temporomandibular joint osteoarthritis (TMJ OA) is common degenerative disease with few effective disease-modifying treatments in clinic. Fibroblast growth factor (FGF) signaling is implicated in articular cartilage homeostasis, but the functional roles of FGFR1 in TMJ OA remain largely unknown. In this study, we report that deletion of Fgfr1 in TMJ chondrocytes delayed the TMJ OA progression in age-associated spontaneous OA model and abnormal dental occlusion OA model. Immunohistochemical staining revealed that Fgfr1 deficiency decreased the expressions of matrix metalloproteinase-13 (MMP13),A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) , COL10A1, while increased aggrecan expression level in two TMJ OA models...
April 24, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29688920/mixed-treatment-comparisons-for-nonsurgical-treatment-of-knee-osteoarthritis-a-network-meta-analysis
#5
David S Jevsevar, Peter B Shores, Kyle Mullen, Danielle M Schulte, Gregory A Brown, Deborah S Cummins
INTRODUCTION: Knee osteoarthritis (KOA) is a significant health problem with lifetime risk of development estimated to be 45%. Effective nonsurgical treatments are needed for the management of symptoms. METHODS: We designed a network meta-analysis to determine clinically relevant effectiveness of nonsteroidal anti-inflammatory drugs, acetaminophen, intra-articular (IA) corticosteroids, IA platelet-rich plasma, and IA hyaluronic acid compared with each other as well as with oral and IA placebos...
May 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29688919/surgical-management-of-osteoarthritis-of-the-knee
#6
Robert H Quinn, Jayson N Murray, Ryan Pezold, Kaitlyn S Sevarino
The American Academy of Orthopaedic Surgeons has developed Appropriate Use Criteria (AUC) for Surgical Management of Osteoarthritis of the Knee. Evidence-based information, in conjunction with the clinical expertise of physicians, was used to develop the criteria to improve patient care and obtain best outcomes while considering the subtleties and distinctions necessary in making clinical decisions. The Surgical Management of Osteoarthritis of the Knee AUC clinical patient scenarios were derived from indications of patients under consideration for surgical treatment of osteoarthritis of the knee as well as from current evidence-based clinical practice guidelines and supporting literature to identify the appropriateness of the three treatments...
May 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29687303/effects-of-psidium-guajava-linn-leaf-extract-in-japanese-subjects-with-knee-pain-a-randomized-double-blind-placebo-controlled-parallel-pilot-study
#7
Shingo Kakuo, Takashi Fushimi, Keiko Kawasaki, Junji Nakamura, Noriyasu Ota
The extract of Psidium guajava Linn. (guava) leaf was recently revealed to suppress the advance of osteoarthritis (OA) in rat anterior cruciate ligament-transection models. To investigate the efficacy of guava leaf extract in improving knee pain, which is a common symptom of OA, we conducted a double-blind parallel pilot clinical study in Japanese subjects with knee pain. The subjects, who had no medical history of knee treatment, were randomly assigned to two groups with similar total Japanese Knee Osteoarthritis Measure (JKOM) scores...
April 23, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29686884/exercise-therapy-patient-education-and-patellar-taping-in-the-treatment-of-adolescents-with-patellofemoral-pain-a-prospective-pilot-study-with-6-months-follow-up
#8
Michael S Rathleff, Camilla R Rathleff, Sinead Holden, Kristian Thorborg, Jens L Olesen
Background: Patellofemoral pain (PFP) is the most common knee condition among adolescents, with a prevalence of 6-7% resulting in reduced function and quality of life. Exercise therapy is recommended for treating PFP, but has only been tested in older adolescents (15-19 years). This pilot study aimed to investigate the adherence to, and clinical effects of, exercise and patient education in young adolescents (12-16 years), with PFP. Methods: Twenty adolescents (16 females) with PFP were recruited from a population-based cohort to undergo a 3-month multimodal intervention...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29685834/effect-of-increased-coronal-inclination-of-the-tibial-plateau-after-opening-wedge-high-tibial-osteotomy
#9
Yasushi Akamatsu, Ken Kumagai, Hideo Kobayashi, Masaki Tsuji, Tomoyuki Saito
PURPOSE: To assess whether the increased inclination of the tibial plateau on the coronal view after opening-wedge high tibial osteotomy affects radiographic coronal alignment, clinical outcomes, and cartilage findings. METHODS: After adjustment for the preoperative medial proximal tibial angle (MPTA), patients who underwent opening-wedge high tibial osteotomy were retrospectively divided into those with postoperative MPTA values of 95° or less (normal group) and greater than 95° (increased group), with each group containing 43 knees...
April 20, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29685524/medial-meniscal-extrusion-detection-evaluation-and-clinical-implications
#10
REVIEW
Nayanatara Swamy, Vibhor Wadhwa, Gitanjali Bajaj, Avneesh Chhabra, Tarun Pandey
The menisci play an important role in knee kinematics. Their unique anatomy allows them to channel forces generated during knee movements through the larger tibio-femoral condylar surfaces while simultaneously resisting deleterious hoop stresses. Although physiologic meniscal extrusion occurs with every knee joint movement, pathologic meniscal extrusion subjects the knee to persistent and excessive load transmission. This renders the knee structures susceptible to injury or exacerbates worsening of existing knee joint internal derangement...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29685500/evidence-of-generalised-mechanical-hyperalgesia-in-patients-with-advanced-knee-osteoarthritis-undergoing-total-knee-arthroplasty
#11
Khalid Jaber, Shaun O'Leary, Ashley Pedler, Michele Sterling, Michael McAuliffe
BACKGROUND AND OBJECTIVE: Persistent pain is reported in up to 34% of patients following total knee arthroplasty (TKA) for management of knee osteoarthritis (KOA). Persistent pain in this group is thought to be at least partly reflective of pain sensory hypersensitivity. The objective of this study was to evaluate sensory hypersensitivity, using mechanical and thermal quantitative sensory testing, in patients about to undergo TKA. DESIGN AND METHODS: Pressure pain thresholds (PPT) and cold pain thresholds (CPT) were recorded from 30 participants prior to their TKA, and compared with recordings taken from 30 healthy control participants of similar age and gender...
April 20, 2018: Knee
https://www.readbyqxmd.com/read/29685141/sinew-acupuncture-for-knee-osteoarthritis-study-protocol-for-a-randomized-sham-controlled-trial
#12
Kwok Yin Au, Haiyong Chen, Wing Chung Lam, Chiu On Chong, Andrew Lau, Varut Vardhanabhuti, Kin Cheung Mak, Fei Jiang, Wing Yi Lam, Fung Man Wu, Hiu Ngok Chan, Yan Wah Ng, Bacon Fung-Leung Ng, Eric Tat-Chi Ziea, Lixing Lao
BACKGROUND: Sinew acupuncture is a new modality of acupuncture in which needles are inserted into acupoints, ashi points or spasm points of sinew and muscles along the meridian sinew pathway. A previous observational study revealed that sinew acupuncture has immediate analgesic effects on various soft tissue injuries, including knee injuries. However, no rigorous trials have been conducted. This study aims to examine whether sinew acupuncture can safely relieve pain and symptoms of knee osteoarthritis (KOA) and improve patients' functional movement and quality of life...
April 23, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29684539/fewer-complications-after-uka-than-tka-in-patients-over-85-years-of-age-a-case-control-study
#13
Quentin Ode, Romain Gaillard, Cécile Batailler, Yannick Herry, Philippe Neyret, Elvire Servien, Sébastien Lustig
INTRODUCTION: Implanting a knee prosthesis in patients aged over 85 years is not without risk. Unicompartmental knee arthroplasty (UKA) is reputed to show lower morbidity and mortality than total knee arthroplasty (TKA). Elderly patients with isolated unicompartmental osteoarthritis without specific contraindications are thus good candidates for this procedure. The present retrospective case-control study compared complications rates in elderly patients receiving UKA versus TKA. The study hypothesis was that UKA incurs fewer complications, with equivalent functional results...
April 20, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29684218/what-is-the-evidence-for-a-role-for-diet-and-nutrition-in-osteoarthritis
#14
Sally Thomas, Heather Browne, Ali Mobasheri, Margaret P Rayman
As current treatment options in OA are very limited, OA patients would benefit greatly from some ability to self-manage their condition. Since diet may potentially affect OA, we reviewed the literature on the relationship between nutrition and OA risk or progression, aiming to provide guidance for clinicians. For overweight/obese patients, weight reduction, ideally incorporating exercise, is paramount. The association between metabolic syndrome, type-2 diabetes and OA risk or progression may partly explain the apparent benefit of dietary-lipid modification resulting from increased consumption of long-chain omega-3 fatty-acids from oily fish/fish oil supplements...
May 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29684166/development-and-evaluation-of-the-boston-university-osteoarthritis-functional-pain-short-form-bu-oa-fps
#15
Adam P Goode, Pengshend Ni, Alan Jette, G Kelley Fitzgerald
Background: Pragmatic studies have gained popularity, thus emphasizing the need for patient-reported outcomes (PRO) to be integrated into electronic health records. Objective: This study describes the development of a customized short form from the Boston University Osteoarthritis Functional Assessment PRO (BU-OA-PRO) for a specific pragmatic clinical trial. Methods: A Functional Pain Short Form was created from an existing item bank of deidentified data in the BU-OA-PRO...
April 19, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29683803/is-cemented-or-cementless-femoral-stem-fixation-more-durable-in-patients-older-than-75-years-of-age-a-comparison-of-the-best-performing-stems
#16
Michael Tanzer, Stephen E Graves, Andrea Peng, Andrew J Shimmin
BACKGROUND: There is ongoing debate concerning the best method of femoral fixation in older patients receiving primary THA. Clinical studies have shown high survivorship for cemented and cementless femoral stems. Arthroplasty registry studies, however, have universally shown that cementless stems are associated with a higher rate of revision in this patient population. It is unclear if the difference in revision rate is a reflection of the range of implants being used for these procedures rather than the mode of fixation...
April 9, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29683374/finite-element-analysis-of-the-effect-of-high-tibial-osteotomy-correction-angle-on-articular-cartilage-loading
#17
Zahra Trad, Abdelwahed Barkaoui, Moez Chafra, João Manuel Rs Tavares
Osteoarthritis is a globally common disease that imposes a considerable ongoing health and economic burden on the socioeconomic system. As more and more biomechanical factors have been explored, malalignment of the lower limb has been found to influence the load distribution across the articular surface of the knee joint substantially. In this work, a three-dimensional finite element analysis was carried out to investigate the effect of varying the high tibial osteotomy correction angle on the stress distribution in both compartments of the human knee joint...
April 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29682329/active-discopathy-a-clinical-reality
#18
REVIEW
Margaux Boisson, Marie-Martine Lefèvre-Colau, François Rannou, Christelle Nguyen
In the late 1980s, the description by Modic and colleagues of elementary discovertebral changes detected on MRI (Modic classification) suggested for the first time a possible correlation between anatomical and clinical features in a subgroup of patients with non-specific chronic low back pain. Degenerative disc disease is frequent and usually asymptomatic, but Modic 1 changes in the vertebral endplates adjacent to a degenerated disc are associated with inflammatory-like chronic low back pain and low-grade local and systemic inflammation, which led to the concept of 'active discopathy'...
2018: RMD Open
https://www.readbyqxmd.com/read/29681797/electroacupuncture-potentiates-cannabinoid-receptor-mediated-descending-inhibitory-control-in-a-mouse-model-of-knee-osteoarthritis
#19
Xiao-Cui Yuan, Bing Zhu, Xiang-Hong Jing, Li-Ze Xiong, Cai-Hua Wu, Fang Gao, Hong-Ping Li, Hong-Chun Xiang, He Zhu, Bin Zhou, Wei He, Chuan-You Lin, Hui-Lin Pan, Qiang Wang, Man Li
Knee osteoarthritis (KOA) is a highly prevalent, chronic joint disorder, which can lead to chronic pain. Although electroacupuncture (EA) is effective in relieving chronic pain in the clinic, the involved mechanisms remain unclear. Reduced diffuse noxius inhibitory controls (DNIC) function is associated with chronic pain and may be related to the action of endocannabinoids. In the present study, we determined whether EA may potentiate cannabinoid receptor-mediated descending inhibitory control and inhibit chronic pain in a mouse model of KOA...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29680400/an-investigation-of-mechanical-nociceptive-thresholds-in-dogs-with-hind-limb-joint-pain-compared-to-healthy-control-dogs
#20
L K Harris, H R Whay, J C Murrell
This study investigated the effects of osteoarthritis (OA) on somatosensory processing in dogs using mechanical threshold testing. A pressure algometer was used to measure mechanical thresholds in 27 dogs with presumed hind limb osteoarthritis and 28 healthy dogs. Mechanical thresholds were measured at the stifles, radii and sternum, and were correlated with scores from an owner questionnaire and a clinical checklist, a scoring system that quantified clinical signs of osteoarthritis. The effects of age and bodyweight on mechanical thresholds were also investigated...
April 2018: Veterinary Journal
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