keyword
MENU ▼
Read by QxMD icon Read
search

MNS system

keyword
https://www.readbyqxmd.com/read/28906130/human-movement-responses-to-the-rorschach-and-mirroring-activity-an-fmri-study
#1
Luciano Giromini, Donald J Viglione, Jaime A Pineda, Piero Porcelli, David Hubbard, Alessandro Zennaro, Franco Cauda
It has been suggested that the Rorschach human movement (M) response could be associated with an embodied simulation mechanism mediated by the mirror neuron system (MNS). To date, evidence for this hypothesis comes from two electroencephalogram studies and one repetitive transcranial magnetic stimulation study. To provide additional data on this topic, the Rorschach was administered during fMRI to a sample of 26 healthy adult volunteers. Activity in MNS-related brain areas temporally associated with M responses was compared with such activity for other, non-M Rorschach responses...
September 1, 2017: Assessment
https://www.readbyqxmd.com/read/28890691/predicting-intentions-of-a-familiar-significant-other-beyond-the-mirror-neuron-system
#2
Stephanie Cacioppo, Elsa Juan, George Monteleone
Inferring intentions of others is one of the most intriguing issues in interpersonal interaction. Theories of embodied cognition and simulation suggest that this mechanism takes place through a direct and automatic matching process that occurs between an observed action and past actions. This process occurs via the reactivation of past self-related sensorimotor experiences within the inferior frontoparietal network (including the mirror neuron system, MNS). The working model is that the anticipatory representations of others' behaviors require internal predictive models of actions formed from pre-established, shared representations between the observer and the actor...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28863534/sers-active-self-assembled-diphenylalanine-micro-nanostructures-a-combined-experimental-and-theoretical-investigation
#3
Sergio Kogikoski, Soma Khanra, Wendel A Alves, Suchismita Guha
Enhancing Raman signatures of molecules by self-assembled metal nanoparticles, nanolithography patterning, or by designing plasmonic nanostructures is widely used for detection of low abundance biological systems. Self-assembled peptide nanostructures provide a natural template for tethering Au and Ag nanoparticles due to its fractal surface. Here, we show the use of L,L-diphenylalanine micro-nanostructures (FF-MNSs) for the organization of Ag and Au nanoparticles (Nps) and its potential as surface-enhanced Raman scattering (SERS)-active substrates...
August 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28854515/intravenous-immunoglobulin-in%C3%A2-the%C3%A2-management-of-a-rare-cause-of%C3%A2-hemolytic-disease-of-the-newborn-anti-sara-antibodies
#4
R Venkataraman, K Yusuf
Hemolytic disease of newborn (HDN) is a condition that develops in a fetus, when the IgG molecules produced by the mother pass through the placenta and attack the fetal red blood cells. HDN can occur due to Rh and ABO incompatibilities between the mother and the fetus as well as due to other allo-immune antibodies belonging to Kell (K and k), Duffy (Fya), Kidd (Jka and Jkb), and MNS (M, N, S, and s) systems. Role of intravenous immunoglobulin in management of HDN is not clear.SARA red blood cell antigen, first discovered in 1990 is a low frequency antigen...
August 23, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28829994/language-for-action-motor-resonance-during-the-processing-of-human-and-robotic-voices
#5
G Di Cesare, A Errante, M Marchi, V Cuccio
In this fMRI study we evaluated whether the auditory processing of action verbs pronounced by a human or a robotic voice in the imperative mood differently modulates the activation of the mirror neuron system (MNs). The study produced three results. First, the activation pattern found during listening to action verbs was very similar in both the robot and human conditions. Second, the processing of action verbs compared to abstract verbs determined the activation of the fronto-parietal circuit classically involved during the action goal understanding...
August 19, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28821461/cutaneous-vaccination-with-coated-microneedles-prevents-development-of-airway-allergy
#6
Akhilesh Kumar Shakya, Chang Hyun Lee, Harvinder Singh Gill
Allergy cases are increasing worldwide. Currently allergies are treated after their appearance in patients. However, now there is effort to make a preventive vaccine against allergies. The rationale is to target patient populations that are already sensitized to allergens but have yet to develop severe forms of the allergic disease, or who are susceptible to allergy development but have not yet developed them. Subcutaneous injections and the sublingual route have been used as the primary mode of preventive vaccine delivery...
August 15, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28819449/self-assembly-dna-polyplex-vaccine-inside-dissolving-microneedles-for-high-potency-intradermal-vaccination
#7
Jing-Fong Liao, Jin-Ching Lee, Chun-Kuang Lin, Kuo-Chen Wei, Pin-Yuan Chen, Hung-Wei Yang
The strong immunogenicity induction is the powerful weapon to prevent the virus infections. This study demonstrated that one-step synthesis of DNA polyplex vaccine in microneedle (MN) patches can induce high immunogenicity through intradermal vaccination and increase the vaccine stability for storage outside the cold chain. More negative charged DNA vaccine was entrapped into the needle region of MNs followed by DNA polyplex formation with branched polyethylenimine (bPEI) pre-coated in the cavities of polydimethylsiloxane (PDMS) molds that can deliver more DNA vaccine to immune-cell rich epidermis with high transfection efficiency...
2017: Theranostics
https://www.readbyqxmd.com/read/28747684/generation-and-validation-of-novel-adeno-associated-viral-vectors-for-the-analysis-of-ca-2-homeostasis-in-motor-neurons
#8
Rosa Pia Norante, Maria Lina Massimino, Paolo Lorenzon, Agnese De Mario, Caterina Peggion, Mattia Vicario, Mattia Albiero, Maria Catia Sorgato, Raffaele Lopreiato, Alessandro Bertoli
A finely tuned Ca(2+) homeostasis in restricted cell domains is of fundamental importance for neurons, where transient Ca(2+) oscillations direct the proper coordination of electro-chemical signals and overall neuronal metabolism. Once such a precise regulation is unbalanced, however, neuronal functions and viability are severely compromised. Accordingly, disturbed Ca(2+) metabolism has often been claimed as a major contributor to different neurodegenerative disorders, such as amyotrophic lateral sclerosis that is characterised by selective motor neuron (MN) damage...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28740383/enhanced-immunization-via-dissolving-microneedle-array-based-delivery-system-incorporating-subunit-vaccine-and-saponin-adjuvant
#9
Ji-Hui Zhao, Qi-Bo Zhang, Bao Liu, Xiang-Hua Piao, Yu-Lu Yan, Xiao-Ge Hu, Kuan Zhou, Yong-Tai Zhang, Nian-Ping Feng
PURPOSE: To enhance the immunogenicity of the model subunit vaccine, ovalbumin (OVA) was combined with platycodin (PD), a saponin adjuvant. To reduce the toxicity of PD, OVA, and adjuvant were loaded together into liposomes before being incorporated into a dissolving microneedle array. METHODS: OVA- and PD-loaded liposomes (OVA-PD-Lipos) were prepared using the film dispersion method. Their uptake behavior, toxicity to mouse bone marrow dendritic cells (BMDCs), and hemolytic activity to rabbit red blood cells (RBCs) were evaluated...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28724783/intra-and-intersegmental-influences-among-central-pattern-generating-networks-in-the-walking-system-of-the-stick-insect
#10
Charalampos Mantziaris, Till Bockemühl, Philip Holmes, Anke Borgmann, Silvia Daun, Ansgar Bueschges
In order to efficiently move around, animals need to coordinate their limbs. Proper, context-dependent coupling among the neural networks underlying leg movement is necessary for generating intersegmental coordination. In the slow-walking stick insect local sensory information is very important for shaping coordination. However, central coupling mechanisms among segmental central pattern generators (CPGs) may also contribute to this. Here, we analyzed the interactions between contralateral networks that drive the depressor trochanteris muscle of the legs in both isolated and interconnected deafferented thoracic ganglia of the stick insect upon application of pilocarpine, a muscarinic acetylcholine receptor agonist...
July 19, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28722833/targeted-next-generation-sequencing-using-a-multigene-panel-in-myeloid-neoplasms-implementation-in-clinical-diagnostics
#11
B Maes, J Willemse, A Broekmans, R Smets, B Cruys, N Put, V Madoe, M Janssen, O Soepenberg, G Bries, I Vrelust, R Achten, K Van Pelt, K Buvé, K Theunissen, V Peeters, G Froyen
INTRODUCTION: Detection of mutations in patients with myeloid neoplasms (MNs) has shown great potential for diagnostic and prognostic purposes. Next-generation sequencing (NGS) is currently implemented for the diagnostic profiling of the four major MN subgroups. METHODS: First, we validated the targeted NGS approach using the TruSight Myeloid panel. Next, we screened 287 patients with a clinical suspicion of MN and 61 follow-up patients with documented MN. RESULTS: Validation of the NGS workflow resulted in maximal precision, accuracy, sensitivity, and specificity for gene variants with an allele frequency of at least 5% and a minimal read depth of 300...
July 19, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28673921/two-social-brains-neural-mechanisms-of-intersubjectivity
#12
REVIEW
Kai Vogeley
It is the aim of this article to present an empirically justified hypothesis about the functional roles of the two social neural systems, namely the so-called 'mirror neuron system' (MNS) and the 'mentalizing system' (MENT, also 'theory of mind network' or 'social neural network'). Both systems are recruited during cognitive processes that are either related to interaction or communication with other conspecifics, thereby constituting intersubjectivity. The hypothesis is developed in the following steps: first, the fundamental distinction that we make between persons and things is introduced; second, communication is presented as the key process that allows us to interact with others; third, the capacity to 'mentalize' or to understand the inner experience of others is emphasized as the fundamental cognitive capacity required to establish successful communication...
August 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28661688/solution-synthesis-of-nonequilibrium-zincblende-mns-nanowires
#13
Li Zhang, Su You, Ming Zuo, Qing Yang
Uniform four-coordinate nonequilibrium MnS nanowires mainly in zincblende structure, other than the stable rock-salt phase, are reported for the first time. The MnS nanowires are grown via a solution-solid-solid model from the reaction of a Mn(II) source with dibenzyl disulfide in oleylamine at 180-200 °C catalyzed by Ag2S nanocrystals in a body-centered cubic (bcc) fast-ionic phase transformed from their low-temperature monoclinic form. Investigations show that most of the zincblende MnS nanowires are grown along the ⟨112⟩ zone axis but a small proportion grow along the ⟨111⟩ZB/⟨0001⟩Wur axis with zincblende/defect-section and/or wurtzite/defect-section superlattices connected with the stems along the ⟨112⟩ direction...
July 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28658782/unusually-detected-anti-m-antibody-presenting-as-cross-match-incompatibility-in-a-female-child-diagnosed-with-small-round-cell-tumour
#14
Sheetal Anand Chandak, Aruna Vishwanath Vanikar
MNS antigen system is one of the human blood group systems. Anti-M antibody is a relatively common, naturally occurring antibody of IgM variety. Clinically significant anti-M antibody is reactive at 37°C in the anti-human globulin phase due to high thermal amplitude of IgM component or presence of IgG component. If anti-M antibody is activated at 37°C or in the anti-human globulin phase, it may cause delayed haemolytic transfusion reactions or haemolytic disease of newborn, which suggest variable clinical significance...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28645642/ngs-and-blood-group-systems-state-of-the-art-and-perspectives
#15
Y Fichou, C Férec
Molecular analysis, or genotyping, of genes involved in the expression of blood group antigens has been a standard strategy used in immunohaematology laboratories routinely. For the past ten years, next-generation sequencing (NGS), or second-generation sequencing, has become the reference method in genetics. Extensive study of distinct targets, large genomic regions, and even whole genome is henceforth possible by this approach at minimal cost. Blood group genotyping has thus taken advantage of this technological advent...
June 20, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28641519/neural-stem-cells-and-human-induced-pluripotent-stem-cells-to-model-rare-cns-diseases
#16
Lidia De Filippis, Cristina Zalfa, Daniela Ferrari
Despite the great effort spent over the last decades to unravel the pathological mechanisms underpinning the development of central nervous system disorders, most of them remain still unclear. In particular, the study of rare brain diseases is hurdled by the lack of post-mortem samples and of reliable epidemiological studies, thus the setting of in vitro modeling systems appears essential to dissect the puzzle of genetic and environmental alterations affecting neural cells viability and functionality The isolation and expansion in vitro of embryonic (ESC) and fetal neural stem cells (NSC) from human tissue has efficiently allowed to model several neurological diseases "in a dish" and has also provided a novel platform to test potential therapeutic strategies in a pre-clinical setting...
June 15, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28622300/the-als-linked-e102q-mutation-in-sigma-receptor-1-leads-to-er-stress-mediated-defects-in-protein-homeostasis-and-dysregulation-of-rna-binding-proteins
#17
Alice Dreser, Jan Tilmann Vollrath, Antonio Sechi, Sonja Johann, Andreas Roos, Alfred Yamoah, Istvan Katona, Saeed Bohlega, Dominik Wiemuth, Yuemin Tian, Axel Schmidt, Jörg Vervoorts, Marc Dohmen, Cordian Beyer, Jasper Anink, Eleonora Aronica, Dirk Troost, Joachim Weis, Anand Goswami
Amyotrophic lateral sclerosis (ALS) is characterized by the selective degeneration of motor neurons (MNs) and their target muscles. Misfolded proteins which often form intracellular aggregates are a pathological hallmark of ALS. Disruption of the functional interplay between protein degradation (ubiquitin proteasome system and autophagy) and RNA-binding protein homeostasis has recently been suggested as an integrated model that merges several ALS-associated proteins into a common pathophysiological pathway...
October 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28604865/investigation-of-zinc-ion-storage-of-transition-metal-oxides-sulfides-and-borides-in-zinc-ion-battery-systems
#18
Wenbao Liu, Jianwu Hao, Chengjun Xu, Jian Mou, Liubing Dong, Fuyi Jiang, Zhuang Kang, Junlin Wu, Baozheng Jiang, Feiyu Kang
Zn-ion batteries have been widely investigated due to their low cost, high safety and eco-friendliness. We comprehensively evaluate the performance of oxides (MoO3, TiO2, and Fe3O4), sulfides (MoS2, WS2, and MnS) and borides (TiB2 and ZrB2) in zinc ion battery systems. It is found that MnS is a good alternative cathode material with a reversible capacity of 221 mA h g(-1), while the other materials show different behaviours.
June 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28600672/significant-reduction-in-procedure-duration-in-remote-magnetic-guided-catheter-ablation-of-atrial-fibrillation-using-the-third-generation-magnetic-navigation-system
#19
Tilman Maurer, Christian Sohns, Sebastian Deiss, Laura Rottner, Peter Wohlmuth, Bruno Reißmann, Christian H Heeger, Christine Lemes, Johannes Riedl, Francesco Santoro, Shibu Mathew, Andreas Metzner, Feifan Ouyang, Karl-Heinz Kuck, Erik Wissner
PURPOSE: The magnetic navigation system (MNS) has shown to be safe and effective for catheter ablation of atrial fibrillation (AF). However, longer procedure duration as compared to manual catheter ablation may limit its widespread use. This study aimed to assess the impact of the newest generation MNS using an optimized mapping and ablation protocol on the efficacy and safety of remote magnetic catheter (RMC)-guided pulmonary vein isolation (PVI). METHODS: This observational study included 52 patients with symptomatic AF who underwent RMC-guided PVI using the second-generation MNS Niobe II (initial 28 patients, group I) or the third-generation MNS Niobe ES in combination with an optimized mapping and ablation protocol (24 patients, group II)...
September 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28560812/threshold-position-control-of-anticipation-in-humans-a-possible-role-of-corticospinal-influences
#20
Lei Zhang, Nicolas A Turpin, Anatol G Feldman
KEY POINTS: Sudden unloading of preloaded wrist muscles elicits motion to a new wrist position. Such motion is prevented if subjects unload muscles using the contralateral arm (self-unloading). Corticospinal influences originated from the primary motor cortex maintain tonic influences on motoneurons of wrist muscles before sudden unloading but modify these influences prior to the onset and until the end of self-unloading. Results are interpreted based on the previous finding that intentional actions are caused by central, particularly corticospinal, shifts in the spatial thresholds at which wrist motoneurons are activated, thus predetermining the attractor point at which the neuromuscular periphery achieves mechanical balance with environment forces...
August 1, 2017: Journal of Physiology
keyword
keyword
116649
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"