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Duffy system

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https://www.readbyqxmd.com/read/28818038/role-of-the-type-vi-secretion-systems-during-disease-interactions-of-erwinia-amylovora-with-its-plant-host
#1
Tim Kamber, Joël F Pothier, Cosima Pelludat, Fabio Rezzonico, Brion Duffy, Theo H M Smits
BACKGROUND: Type VI secretion systems (T6SS) are widespread among Gram-negative bacteria and have a potential role as essential virulence factors or to maintain symbiotic interactions. Three T6SS gene clusters were identified in the genome of E. amylovora CFBP 1430, of which T6SS-1 and T6SS-3 represent complete T6SS machineries, while T6SS-2 is reduced in its gene content. RESULTS: To assess the contribution of T6SSs to virulence and potential transcriptomic changes of E...
August 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28813042/the-carotenoid-pathway-what-is-important-for-excitation-quenching-in-plant-antenna-complexes
#2
Kieran F Fox, Vytautas Balevičius, Jevgenij Chmeliov, Leonas Valkunas, Alexander V Ruban, Christopher D P Duffy
Plant light-harvesting is regulated by the Non-Photochemical Quenching (NPQ) mechanism involving the reversible formation of excitation quenching sites in the Photosystem II (PSII) antenna in response to high light. While the major antenna complex, LHCII, is known to be a site of NPQ, the precise mechanism of excitation quenching is not clearly understood. A preliminary model of the quenched crystal structure of LHCII implied that quenching arises from slow energy capture by Car pigments. It predicted a thoroughly quenched system but offered little insight into the defining aspects of this quenching...
August 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28797351/implant-and-midterm-outcomes-of-the-subcutaneous-implantable-cardioverter-defibrillator-registry-the-effortless-study
#3
Lucas Boersma, Craig Barr, Reinoud Knops, Dominic Theuns, Lars Eckardt, Petr Neuzil, Marcoen Scholten, Margaret Hood, Juergen Kuschyk, Paul Jones, Elizabeth Duffy, Michael Husby, Kenneth Stein, Pier D Lambiase
BACKGROUND: The subcutaneous implantable cardioverter-defibrillator (S-ICD) was developed to defibrillate ventricular arrhythmias, avoiding drawbacks of transvenous leads. The global EFFORTLESS S-ICD (Evaluation oF FactORs ImpacTing CLinical Outcome and Cost EffectiveneSS of the S-ICD) registry is collecting outcomes in 985 patients during a 5-year follow-up. OBJECTIVES: The primary goal of the EFFORTLESS registry is to determine the safety of the S-ICD by evaluating complications and inappropriate shock rate...
August 15, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28766698/allocation-not-male-resistance-increases-male-frequency-during-epidemics-a-case-study-in-facultatively-sexual-hosts
#4
Jessica L Hite, Rachel M Penczykowski, Marta S Shocket, Katherine Griebel, Alexander T Strauss, Meghan A Duffy, Carla E Cáceres, Spencer R Hall
Why do natural populations vary in the frequency of sexual reproduction? Virulent parasites may help explain why sex is favored during disease epidemics. To illustrate, we show a higher frequency of males and sexually produced offspring in natural populations of a facultative parthenogenetic host during fungal epidemics. In a multi-year survey of 32 lakes, the frequency of males (an index of sex) was higher in populations of zooplankton hosts with larger epidemics. A lake mesocosm experiment established causality: experimental epidemics produced a higher frequency of males relative to disease-free controls...
August 2, 2017: Ecology
https://www.readbyqxmd.com/read/28765255/malignancy-in-pediatric-onset-systemic-lupus-erythematosus
#5
Sasha Bernatsky, Ann E Clarke, Omid Zahedi Niaki, Jeremy Labrecque, Laura E Schanberg, Earl D Silverman, Kristen Hayward, Lisa Imundo, Hermine I Brunner, Kathleen A Haines, Randy Q Cron, Kiem Oen, Linda Wagner-Weiner, Alan M Rosenberg, Kathleen M O'Neil, Ciarán M Duffy, Emily von Scheven, Lawrence Joseph, Jennifer L Lee, Rosalind Ramsey-Goldman
OBJECTIVE: To determine cancer incidence in a large pediatric-onset systemic lupus erythematosus (SLE) population. METHODS: Data were examined from 12 pediatric SLE registries in North America. Patients were linked to their regional cancer registries to detect cancers observed after cohort entry, defined as date first seen in the clinic. The expected number of malignancies was obtained by multiplying the person-years in the cohort (defined from cohort entry to end of followup) by the geographically matched age-, sex-, and calendar year-specific cancer rates...
August 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28747668/deformability-based-cell-sorting-using-microfluidic-ratchets-enabling-phenotypic-separation-of-leukocytes-directly-from-whole-blood
#6
Quan Guo, Simon P Duffy, Kerryn Matthews, Emel Islamzada, Hongshen Ma
The separation of leukocytes from whole blood is a prerequisite for many biological assays. Traditional methods require significant sample volumes and are often undesirable because they expose leukocytes to harsh physical or chemical treatment. Existing microfluidic approaches can work with smaller volumes, but lack selectivity. In particular, the selectivity of microfluidic systems based on microfiltration is limited by fouling due to clogging. Here, we developed a method to separate leukocytes from whole blood using the microfluidic ratchet mechanism, which filters the blood sample using a matrix of micrometer-scale tapered constrictions...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28712646/live-births-after-embryo-selection-using-morphokinetics-versus-conventional-morphology-a-retrospective-analysis
#7
Simon Fishel, Alison Campbell, Sue Montgomery, Rachel Smith, Lynne Nice, Samantha Duffy, Lucy Jenner, Kathyrn Berrisford, Louise Kellam, Rob Smith, Ivy D'Cruz, Ashley Beccles
The increasing corpus of clinical studies using time-lapse imaging for embryo selection demonstrates considerable variation in study protocols and only limited-sized study cohorts. Outcome measures are based on implantation or clinical pregnancy; some predict blastulation from early cleavage-stage data, and few have evaluated live birth. Erroneously, most studies treat the embryos as independent variables and do not include patient or treatment variables in the statistical analyses. In this study, cohort size was 14,793 patients and 23,762 cycles...
June 23, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28690827/stabilizing-mechanisms-in-a-food-web-with-an-introduced-omnivore
#8
Monica Granados, Sean Duffy, Christopher W McKindsey, Gregor F Fussmann
Intraguild predation (IGP) is an omnivorous food web configuration in which the top predator consumes both a competitor (consumer) and a second prey that it shares with the competitor. This omnivorous configuration occurs frequently in food webs, but theory suggests that it is unstable unless stabilizing mechanisms exist that can decrease the strength of the omnivore and consumer interaction. Although these mechanisms have been documented in native food webs, little is known about whether they operate in the context of an introduced species...
July 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28650643/high-pressure-study-of-perovskites-and-postperovskites-in-the-mg-fe-geo3-system
#9
Camelia V Stan, Rajkrishna Dutta, Robert J Cava, Vitali B Prakapenka, Thomas S Duffy
The effect of incorporation of Fe(2+) on the perovskite (Pbnm) and postperovskite (Cmcm) structures was investigated in the (Mg,Fe)GeO3 system at high pressures and temperatures using laser-heated diamond anvil cell and synchrotron X-ray diffraction. Samples with compositions of Mg# ≥ 48 were shown to transform to the perovskite (∼30 GPa and ∼1500 K) and postperovskite (>55 GPa, ∼1600-1800 K) structures. Compositions with Mg# ≥ 78 formed single-phase perovskite and postperovskite, whereas those with Mg# < 78 showed evidence for partial decomposition...
July 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28648410/the-great-unknown-a-systematic-literature-review-about-risk-associated-with-intraoperative-imaging-during-orthopaedic-surgeries
#10
REVIEW
Amir Matityahu, Ryan K Duffy, Sabine Goldhahn, Alexander Joeris, Peter H Richter, Florian Gebhard
INTRODUCTION: Modern techniques in orthopaedic surgery using minimally invasive procedures, and increased use of fluoroscopic imaging present a potential increased risk to surgeons due to ionizing radiation exposure. This article is a systematic review of recent literature on radiation exposure of orthopaedic surgeons. MATERIALS AND METHODS: Pubmed and Cochrane searches were performed on intraoperative radiation exposure covering English and German articles published between 1...
April 21, 2017: Injury
https://www.readbyqxmd.com/read/28615382/factors-influencing-the-gut-microbiota-inflammation-and-type-2-diabetes
#11
REVIEW
Li Wen, Andrew Duffy
The gut microbiota is a complex community of bacteria residing in the intestine. Animal models have demonstrated that several factors contribute to and can significantly alter the composition of the gut microbiota, including genetics; the mode of delivery at birth; the method of infant feeding; the use of medications, especially antibiotics; and the diet. There may exist a gut microbiota signature that promotes intestinal inflammation and subsequent systemic low-grade inflammation, which in turn promotes the development of type 2 diabetes...
July 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28596615/assessing-national-biodiversity-trends-for-rocky-and-coral-reefs-through-the-integration-of-citizen-science-and-scientific-monitoring-programs
#12
Rick D Stuart-Smith, Graham J Edgar, Neville S Barrett, Amanda E Bates, Susan C Baker, Nicholas J Bax, Mikel A Becerro, Just Berkhout, Julia L Blanchard, Daniel J Brock, Graeme F Clark, Antonia T Cooper, Tom R Davis, Paul B Day, J Emmett Duffy, Thomas H Holmes, Steffan A Howe, Alan Jordan, Stuart Kininmonth, Nathan A Knott, Jonathan S Lefcheck, Scott D Ling, Amanda Parr, Elisabeth Strain, Hugh Sweatman, Russell Thomson
Reporting progress against targets for international biodiversity agreements is hindered by a shortage of suitable biodiversity data. We describe a cost-effective system involving Reef Life Survey citizen scientists in the systematic collection of quantitative data covering multiple phyla that can underpin numerous marine biodiversity indicators at high spatial and temporal resolution. We then summarize the findings of a continental- and decadal-scale State of the Environment assessment for rocky and coral reefs based on indicators of ecosystem state relating to fishing, ocean warming, and invasive species and describing the distribution of threatened species...
February 1, 2017: Bioscience
https://www.readbyqxmd.com/read/28587995/duffy-blood-group-system-new-genotyping-method-and-distribution-in-a-brazilian-extra-amazonian-population
#13
Marina Lobato Martins, Adão Rogerio da Silva, Hadassa Campos Santos, Michelle Teodoro Alves, Luciana Cayres Schmidt, Stela Brener Vertchenko, Luci Maria SantAna Dusse, Maria Clara Fernandes da Silva Malta
Duffy blood group system is of interest in several fields of science including transfusion medicine, immunology and malariology. Although some methods have been developed for Duffy polymorphism genotyping, not all of them have been sufficiently described and validated, and all present limitations. At the same time, the frequency of Duffy alleles and antigens in some densely populated regions of the world are still missing. In this study we present new tests for genotyping the major alleles of the Duffy blood system and describe Duffy alleles and antigens in blood donors and transfusion-dependent patients in Minas Gerais, Brazil...
June 3, 2017: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/28544500/non-communicable-diseases-and-hiv-care-and-treatment-models-of-integrated-service-delivery
#14
REVIEW
Malia Duffy, Bisola Ojikutu, Soa Andrian, Elaine Sohng, Thomas Minior, Lisa R Hirschhorn
OBJECTIVES: Non-communicable diseases (NCD) are a growing cause of morbidity in low-income countries including in people living with human immunodeficiency virus (HIV). Integration of NCD and HIV services can build upon experience with chronic care models from HIV programmes. We describe models of NCD and HIV integration, challenges and lessons learned. METHODS: A literature review of published articles on integrated NCD and HIV programs in low-income countries and key informant interviews were conducted with leaders of identified integrated NCD and HIV programs...
August 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28542602/antimicrobial-resistance-status-of-enterococcus-from-australian-cattle-populations-at-slaughter
#15
Robert S Barlow, Kate E McMillan, Lesley L Duffy, Narelle Fegan, David Jordan, Glen E Mellor
Antimicrobial agents are used in cattle production systems for the prevention and control of bacterial associated diseases. A consequence of their use is the potential development of antimicrobial resistance (AMR). Enterococcus faecium and Enterococcus faecalis that are resistant to antimicrobials are of increased concern to public health officials throughout the world as they may compromise the ability of various treatment regimens to control disease and infection in human medicine. Australia is a major exporter of beef; however it does not have an ongoing surveillance system for AMR in cattle or foods derived from these animals...
2017: PloS One
https://www.readbyqxmd.com/read/28529728/measurements-of-rates-of-cooling-of-a-manikin-insulated-with-different-mountain-rescue-casualty-bags
#16
Christopher Press, Christopher Duffy, Jonathan Williams, Ben Cooper, Neil Chapman
BACKGROUND: Accidental hypothermia is common in those who sustain injuries in remote environments. This is unpleasant and associated with adverse effects on subsequent patient outcomes. To minimise further heat loss, a range of insulating systems are available to mountain rescue teams although the most effective and cost-efficient have yet to be determined. METHODS: Under ambient, still, dry, air conditions, a thermal manikin was filled with water at a temperature of 42 °C and then placed into a given insulation system...
2017: Extreme Physiology & Medicine
https://www.readbyqxmd.com/read/28521386/remobilisation-of-industrial-lead-depositions-in-ash-during-australian-wildfires
#17
Liqin Wu, Mark Patrick Taylor, Heather K Handley
This study examined the recycling of lead (Pb) in ash from wildfires, its source and potential contribution to environmental contamination. Ash from wildfires was collected from four Australian sites following uncontrolled fires during 2012 to 2013 close to major urban populations in Sydney (New South Wales), Hobart (Tasmania) and Adelaide (South Australia). The samples were analysed for their total Pb concentration and Pb isotopic composition to determine the sources of Pb and the extent, if any, of industrial contamination and its recycling into the ecosystem...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28488363/the-role-of-regulatory-t-cells-in-nervous-system-pathologies
#18
REVIEW
Samuel S Duffy, Brooke A Keating, Chamini J Perera, Gila Moalem-Taylor
Regulatory T (Treg) cells are a special subpopulation of immunosuppressive T cells that are essential for sustaining immune homeostasis. They maintain self-tolerance, inhibit autoimmunity, and act as critical negative regulators of inflammation in various pathological states including autoimmunity, injury, and degeneration of the nervous system. Treg cells are known to convey both beneficial and detrimental influences in certain disease contexts, and accumulating research suggests that their action may be altered in a range of peripheral and central nervous system pathologies...
May 10, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28463428/single-layer-cystotomy-closure-of-excised-porcine-bladders-with-barbed-versus-smooth-suture-material
#19
Joshua S Montel, Daniel J Duffy, Hsin-Yi Weng, Lynetta J Freeman
OBJECTIVE: To determine which of 2 suture materials would be superior in terms of closure time and leakage pressure in open single-layer cystotomy closure. STUDY DESIGN: Experimental study. ANIMALS: Twenty-four freshly harvested porcine urinary bladders. METHODS: A cystotomy was performed and the incision closed with a single layer simple continuous suture pattern with barbed (n = 12) or smooth (n = 12) suture...
May 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28438419/importance-of-extended-blood-group-genotyping-in-multiply-transfused-patients
#20
Nadila Haryani Osman, Jameela Sathar, Chooi Fun Leong, Noor Fadzilah Zulkifli, Raja Zahratul Azma Raja Sabudin, Ainoon Othman, Asral Wirda Ahmad Asnawi
Blood group antigen systems are not limited to the ABO blood groups. There is increasing interest in the detection of extended blood group systems on the red cell surface. The conventional method used to determine extended blood group antigens or red cell phenotype is by serological testing, which is based on the detection of visible haemagglutination or the presence of haemolysis. However, this technique has many limitations due to recent exposure to donor red cell, certain drugs or medications or other diseases that may alter the red cell membrane...
April 9, 2017: Transfusion and Apheresis Science
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