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https://www.readbyqxmd.com/read/29660440/the-long-term-effect-of-maternal-dietary-protein-restriction-on-5-ht-1a-receptor-function-and-behavioral-responses-to-stress-in-adulthood
#1
Wenrui Ye, Michael Duffy Pitlock, Martin A Javors, Brent Thompson, James D Lechleiter, Julie G Hensler
Maternal nutrition impacts fetal development, and may play a role in determining resilience to stress and vulnerability to stress-precipitated psychiatric disorders, such as anxiety and depression. In this study, we examined the effect of a reduction in maternal dietary protein during pregnancy on the brain neurochemistry and behavior of offspring. We focused specifically on the serotonin system, the 5-HT1A receptor and the responsivity of offspring as adults to stress. Dams were fed either a low protein diet (10% protein by weight) or isocaloric control diet (20% protein by weight)...
April 13, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29648638/ovulatory-induction-of-scg2-in-human-non-human-primate-and-rodent-granulosa-cells-stimulates-ovarian-angiogenesis
#2
Patrick R Hannon, Diane M Duffy, Katherine L Rosewell, Mats Brännström, James W Akin, Thomas E Curry
The luteinizing hormone (LH) surge is essential for ovulation, but the intrafollicular factors induced by LH that mediate ovulatory processes (e.g. angiogenesis) are poorly understood, especially in women. The role of secretogranin II (SCG2) and its cleaved bioactive peptide, secretoneurin (SN), were investigated as potential novel mediators of ovulation by testing the hypothesis that SCG2/SN is induced in granulosa cells by human chorionic gonadotropin (hCG), via a downstream LH receptor signaling mechanism, and stimulates ovarian angiogenesis...
April 10, 2018: Endocrinology
https://www.readbyqxmd.com/read/29623683/essential-ocean-variables-for-global-sustained-observations-of-biodiversity-and-ecosystem-changes
#3
Patricia Miloslavich, Nicholas J Bax, Samantha E Simmons, Eduardo Klein, Ward Appeltans, Octavio Aburto-Oropeza, Melissa Andersen Garcia, Sonia D Batten, Lisandro Benedetti-Cecchi, David M Checkley, Sanae Chiba, J Emmett Duffy, Daniel C Dunn, Albert Fischer, John Gunn, Raphael Kudela, Francis Marsac, Frank E Muller-Karger, David Obura, Yunne-Jai Shin
Sustained observations of marine biodiversity and ecosystems focused on specific conservation and management problems are needed around the world to effectively mitigate or manage changes resulting from anthropogenic pressures. These observations, while complex and expensive, are required by the international scientific, governance and policy communities to provide baselines against which the effects of human pressures and climate change may be measured and reported, and resources allocated to implement solutions...
April 5, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29602204/high-levels-of-fecundity-in-small-and-isolated-populations-of-a-self-compatible-aloe-pollinated-by-opportunistic-birds-and-bees
#4
Kirsten L Patrick, Steven D Johnson, Karl J Duffy
Plant species that are effective colonizers of transient habitats are expected to have a capacity for uniparental reproduction and show flexibility in pollination systems. Such traits may enable populations to be established from a small number of founding individuals without these populations succumbing to reductions in fecundity arising from pollinator limitation. We tested these predictions for Aloe thraskii (Xanthorrhoeaceae), a succulent treelet that colonizes shifting coastal dunes and has both bird and bee pollinators...
March 30, 2018: Plant Biology
https://www.readbyqxmd.com/read/29570399/temperature-drives-epidemics-in-a-zooplankton-fungus-disease-system-a-trait-driven-approach-points-to-transmission-via-host-foraging
#5
Marta S Shocket, Alexander T Strauss, Jessica L Hite, Maja Šljivar, David J Civitello, Meghan A Duffy, Carla E Cáceres, Spencer R Hall
Climatic warming will likely have idiosyncratic impacts on infectious diseases, causing some to increase while others decrease or shift geographically. A mechanistic framework could better predict these different temperature-disease outcomes. However, such a framework remains challenging to develop, due to the nonlinear and (sometimes) opposing thermal responses of different host and parasite traits and due to the difficulty of validating model predictions with observations and experiments. We address these challenges in a zooplankton-fungus (Daphnia dentifera-Metschnikowia bicuspidata) system...
April 2018: American Naturalist
https://www.readbyqxmd.com/read/29474451/racial-residential-segregation-socioeconomic-disparities-and-the-white-black-survival-gap
#6
Ioana Popescu, Erin Duffy, Joshua Mendelsohn, José J Escarce
OBJECTIVE: To evaluate the association between racial residential segregation, a prominent manifestation of systemic racism, and the White-Black survival gap in a contemporary cohort of adults, and to assess the extent to which socioeconomic inequality explains this association. DESIGN: This was a cross sectional study of White and Black men and women aged 35-75 living in 102 large US Core Based Statistical Areas. The main outcome was the White-Black survival gap...
2018: PloS One
https://www.readbyqxmd.com/read/29435209/the-relative-contribution-of-diurnal-and-nocturnal-pollinators-to-plant-female-fitness-in-a-specialized-nursery-pollination-system
#7
Giovanni Scopece, Lucia Campese, Karl J Duffy, Salvatore Cozzolino
Plants involved in specialized pollinator interactions, such as nursery pollination, may experience trade-offs in their female fitness, as the larvae of their pollinators may also consume seeds produced by the flowers they pollinate. These interactions could potentially shift between mutualism and parasitism, depending on the presence and abundance of both the nursery pollinator and of other pollinators. We investigated the fitness trade-off in a Mediterranean plant (Silene latifolia), which has a specialist nocturnal nursery pollinator moth (Hadena bicruris) and is also visited by several diurnal pollinators...
February 2018: AoB Plants
https://www.readbyqxmd.com/read/29422046/easy-and-fast-method-for-expression-and-native-extraction-of-plasmodium-vivax-duffy-binding-protein-fragments
#8
Darwin Andrés Moreno-Pérez, Luis Alfredo Baquero, Maritza Bermúdez, Laura Alejandra Gómez-Muñoz, Yahson Varela, Manuel Alfonso Patarroyo
BACKGROUND: The Plasmodium vivax Duffy binding protein (PvDBP) has been the most studied ligand binding human reticulocytes to date. This molecule has a cysteine-rich domain in region II (RII) which has been used as control for evaluating the target cell binding activity of several parasite molecules. However, obtaining rPvDBP-RII in a soluble form using the Escherichia coli expression system usually requires laborious and time-consuming steps for recovering the molecule's structure and function, considering it is extracted from inclusion bodies...
February 8, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29418003/in-vitro-evaluation-of-chitosan-copper-chelate-gels-as-a-multimicronutrient-feed-additive-for-cattle
#9
Ciara Duffy, E Dolores O' Riordan, Michael O' Sullivan, Jean-Christophe Jacquier
BACKGROUND: Effective micronutrient supplementation strategies are critical to ensure optimal health and productivity in livestock. The objective of this study was to develop a copper and vitamin (multimicronutrient) delivery system based on chitosan gel beads, and test its suitability, in vitro, for use as a cattle feed additive. RESULTS: Chitosan was chelated with copper sulphate to produce millimetre-scale gel matrices (~2mm). The copper content was significantly increased (from 61 to 95mg...
February 8, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29412982/circadian-rhythm-sleep-wake-disorders-in-older-adults
#10
REVIEW
Jee Hyun Kim, Jeanne F Duffy
The timing, duration, and consolidation of sleep result from the interaction of the circadian timing system with a sleep-wake homeostatic process. When aligned and functioning optimally, this allows wakefulness throughout the day and a long consolidated sleep episode at night. Mismatch between the desired timing of sleep and the ability to fall and remain asleep is a hallmark of the circadian rhythm sleep-wake disorders. This article discusses changes in circadian regulation of sleep with aging; how age influences the prevalence, diagnosis, and treatment of circadian rhythm sleep-wake disorders; and how neurologic diseases in older patients affect circadian rhythms and sleep...
March 2018: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/29378145/assessment-of-common-red-blood-cell-pretreatments-to-yield-an-accurate-serologic-antigen-phenotype-compared-with-genotypepredicted-phenotype
#11
Trina Horn, Janis Hamilton, Joanne Kosanke, Virginia W Hare, Wendy Kluver, Wendy Beres, Sandra Nance, Margaret A Keller
For patients requiring multiple transfusions and patients with positive direct antiglobulin tests (DATs), an extended red blood cell (RBC) phenotype can provide valuable information and help to determine the risk of forming alloantibodies. In some instances, the phenotype may be used for prophylactic matching. Phenotyping in this patient population is often hindered by the presence of circulating donor cells and/or by a positive DAT. Several methods, such as EDTA glycine acid (EGA) treatment to remove IgG, hypotonic saline wash to separate autologous RBCs, or reticulocyte separation, are often used in these situations to isolate patient RBCs for serologic phenotyping...
December 2017: Immunohematology
https://www.readbyqxmd.com/read/29355936/auditory-structural-connectivity-in-preterm-and-healthy-term-infants-during-the-first-postnatal-year
#12
Leire Zubiaurre-Elorza, Annika C Linke, Charlotte Herzmann, Conor J Wild, Hester Duffy, David S C Lee, Victor K Han, Rhodri Cusack
Assessing language development in the first postnatal year is difficult, as receptive and expressive skills are rudimentary. Although outward manifestations of change are limited, the auditory language system is thought to undergo critical development at this age, as the foundations are laid for the rapid onset of spoken language in the second and third years. We recruited 11 infants, 7 healthy controls (gestational age = 40.69 ± 0.56; range from 40 to 41.43) and preterm babies (gestational age = 28...
April 2018: Developmental Psychobiology
https://www.readbyqxmd.com/read/29334375/a-small-molecule-inhibitor-of-the-ubiquitin-activating-enzyme-for-cancer-treatment
#13
Marc L Hyer, Michael A Milhollen, Jeff Ciavarri, Paul Fleming, Tary Traore, Darshan Sappal, Jessica Huck, Judy Shi, James Gavin, Jim Brownell, Yu Yang, Bradley Stringer, Robert Griffin, Frank Bruzzese, Teresa Soucy, Jennifer Duffy, Claudia Rabino, Jessica Riceberg, Kara Hoar, Anya Lublinsky, Saurabh Menon, Michael Sintchak, Nancy Bump, Sai M Pulukuri, Steve Langston, Stephen Tirrell, Mike Kuranda, Petter Veiby, John Newcomb, Ping Li, Jing Tao Wu, Josh Powe, Lawrence R Dick, Paul Greenspan, Katherine Galvin, Mark Manfredi, Chris Claiborne, Benjamin S Amidon, Neil F Bence
The ubiquitin-proteasome system (UPS) comprises a network of enzymes that is responsible for maintaining cellular protein homeostasis. The therapeutic potential of this pathway has been validated by the clinical successes of a number of UPS modulators, including proteasome inhibitors and immunomodulatory imide drugs (IMiDs). Here we identified TAK-243 (formerly known as MLN7243) as a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE), the primary mammalian E1 enzyme that regulates the ubiquitin conjugation cascade...
February 2018: Nature Medicine
https://www.readbyqxmd.com/read/29330014/frequency-of-red-blood-cell-genotypes-in-multi-transfused-patients-and-blood-donors-from-minas-gerais-southeast-brazil
#14
Vitor Mendonça Alves, Fernanda Bernadelli De Vito, Paulo Roberto Juliano Martins, Sheila Soares Silva, Lilian Castilho, Helio Moraes-Souza
BACKGROUND AND OBJECTIVES: The frequency of red blood cell (RBC) antigens in Brazil varies due to differences in the ethnic groups in different regions; however, these studies have not been performed in Minas Gerais, where African admixture is more prevalent in comparison with other states. Due to these facts, this study aimed to determine the frequency of RBC genotypes on Rh, Kell, Duffy and Kidd systems in blood donors and multi-transfused patients from Minas Gerais, Southeast Brazil...
February 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29325571/development-of-a-hospital-based-patient-reported-outcome-framework-for-lung-cancer-patients-a-study-protocol
#15
Natasha Moloczij, Karla Gough, Benjamin Solomon, David Ball, Linda Mileshkin, Mary Duffy, Mei Krishnasamy
BACKGROUND: Patient-reported outcome (PRO) data is central to the delivery of quality health care. Establishing sustainable, reliable and cost-efficient methods for routine collection and integration of PRO data into health information systems is challenging. This protocol paper describes the design and structure of a study to develop and pilot test a PRO framework to systematically and longitudinally collect PRO data from a cohort of lung cancer patients at a comprehensive cancer centre in Australia...
January 11, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29281179/a-high-parasite-density-environment-induces-transcriptional-changes-and-cell-death-in-plasmodium-falciparum-blood-stages
#16
Evelyn S Chou, Sabia Z Abidi, Marian Teye, Aleksandra Leliwa-Sytek, Thomas S Rask, Simon A Cobbold, Gerry Q Tonkin-Hill, Krishanthi S Subramaniam, Anna E Sexton, Darren J Creek, Johanna P Daily, Michael F Duffy, Karen P Day
Transient regulation of Plasmodium numbers below the density that induces fever has been observed in chronic malaria infections in humans. This species transcending control cannot be explained by immunity alone. Using an in vitro system we have observed density dependent regulation of malaria population size as a mechanism to possibly explain these in vivo observations. Specifically, Plasmodium falciparum blood stages from a high but not low-density environment exhibited unique phenotypic changes during the late trophozoite (LT) and schizont stages of the intraerythrocytic cycle...
March 2018: FEBS Journal
https://www.readbyqxmd.com/read/29198986/australian-trends-in-procedural-characteristics-and-outcomes-in-patients-undergoing-percutaneous-coronary-intervention-for-st-elevation-myocardial-infarction
#17
Sinjini Biswas, Stephen J Duffy, Jeffrey Lefkovits, Nick Andrianopoulos, Angela Brennan, Antony Walton, William Chan, Samer Noaman, James A Shaw, Luke Dawson, Andrew Ajani, David J Clark, Melanie Freeman, Chin Hiew, Ernesto Oqueli, Christopher M Reid, Dion Stub
Over the last decade, systems of care for ST-elevation myocardial infarction (STEMI) have evolved to try to improve outcomes and timely access to percutaneous coronary intervention (PCI). There have also been advances in PCI techniques and adjunctive pharmacotherapies. In this study, we sought to determine temporal changes in practices and clinical outcomes of PCI in patients with STEMI. We prospectively collected data on 8,412 consecutive patients undergoing PCI for STEMI between 2005 and 2016 in the multicenter Melbourne Interventional Group registry...
February 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29180681/subthalamic-nucleus-deep-brain-stimulation-does-not-modify-the-functional-deficits-or-axonopathy-induced-by-nigrostriatal-%C3%AE-synuclein-overexpression
#18
D Luke Fischer, Fredric P Manfredsson, Christopher J Kemp, Allyson Cole-Strauss, Jack W Lipton, Megan F Duffy, Nicole K Polinski, Kathy Steece-Collier, Timothy J Collier, Sara E Gombash, Daniel J Buhlinger, Caryl E Sortwell
Subthalamic nucleus deep brain stimulation (STN DBS) protects dopaminergic neurons of the substantia nigra pars compacta (SNpc) against 6-OHDA and MPTP. We evaluated STN DBS in a parkinsonian model that displays α-synuclein pathology using unilateral, intranigral injections of recombinant adeno-associated virus pseudotype 2/5 to overexpress wildtype human α-synuclein (rAAV2/5 α-syn). A low titer of rAAV2/5 α-syn results in progressive forelimb asymmetry, loss of striatal dopaminergic terminal density and modest loss of SNpc dopamine neurons after eight weeks, corresponding to robust human-Snca expression and no effect on rat-Snca, Th, Bdnf or Trk2...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29154744/generation-and-characterization-of-a-novel-candidate-gene-therapy-and-vaccination-vector-based-on-human-species-d-adenovirus-type-56
#19
Margaret R Duffy, Julio Alonso-Padilla, Lijo John, Naresh Chandra, Selina Khan, Monika Z Ballmann, Agnieszka Lipiec, Evert Heemskerk, Jerome Custers, Niklas Arnberg, Menzo Havenga, Andrew H Baker, Angelique Lemckert
The vectorization of rare human adenovirus (HAdV) types will widen our knowledge of this family and their interaction with cells, tissues and organs. In this study we focus on HAdV-56, a member of human Ad species D, and create ease-of-use cloning systems to generate recombinant HAdV-56 vectors carrying foreign genes. We present in vitro transduction profiles for HAdV-56 in direct comparison to the most commonly used HAdV-5-based vector. In vivo characterizations demonstrate that when it is delivered intravenously (i...
January 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29150856/defining-sepsis-on-the-wards-results-of-a-multi-centre-point-prevalence-study-comparing-two-sepsis-definitions
#20
T Szakmany, R Pugh, M Kopczynska, R M Lundin, B Sharif, P Morgan, G Ellis, J Abreu, S Kulikouskaya, K Bashir, L Galloway, H Al-Hassan, T Grother, P McNulty, S T Seal, A Cains, M Vreugdenhil, M Abdimalik, N Dennehey, G Evans, J Whitaker, E Beasant, C Hall, M Lazarou, C V Vanderpump, K Harding, L Duffy, A Guerrier Sadler, R Keeling, C Banks, S W Y Ng, S Y Heng, D Thomas, E W Puw, I Otahal, C Battle, O Minik, R A Lyons, J E Hall
Our aim was to prospectively determine the predictive capabilities of SEPSIS-1 and SEPSIS-3 definitions in the emergency departments and general wards. Patients with National Early Warning Score (NEWS) of 3 or above and suspected or proven infection were enrolled over a 24-h period in 13 Welsh hospitals. The primary outcome measure was mortality within 30 days. Out of the 5422 patients screened, 431 fulfilled inclusion criteria and 380 (88%) were recruited. Using the SEPSIS-1 definition, 212 patients had sepsis...
February 2018: Anaesthesia
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