Durgaramani Sivadasan, Krishnaraju Venkatesan, Jamal Moideen Muthu Mohamed, Saud Alqahtani, Yahya I Asiri, Mennatullah M Faisal, Adel Ehab Ibrahim, Yahya Bin Abdullah Alrashdi, Farid Menaa, Sami El Deeb
Loratadine (LoR) is a highly lipophilic and practically insoluble in water, hence having a low oral bioavailability. As it is formulated as topical gel, it competitively binds with the receptors, thus reducing the side-effects. The objective of this study was to prepare LoR loaded nanosponge (LoR-NS) in gel for topical delivery. Nine different formulations of emulsion were prepared by solvent evaporation method with polyvinyl alcohol (PVA), ethyl cellulose (EC), and dichloromethane (DCM). Based on 32 Full Factorial Design (FFD), optimization was carried out by varying the concentration of LOR:EC ratio and stirring rate...
March 16, 2024: Scientific Reports