keyword
https://read.qxmd.com/read/38533748/stabilization-of-the-neutral-25-hexaphyrin-1-0-1-0-1-0-radical-by-hetero-bimetal-coordination
#1
JOURNAL ARTICLE
Songlin Xue, Yuting Dong, Xiaojuan Lv, Fengxian Qiu, Yue Wang, Hiroyuki Furuta, Toshiharu Teranishi, Fan Wu
Stabilization of hexaphyrin(1.0.1.0.1.0) (named "rosarin") in its 25π radical state is achieved using a hetero-bimetal-coordination strategy. The antiaromatic BF2 complex B-1 was first synthesized, and then rhodium ion was inserted into B-1 to produce the BF2/Rh(CO)2 mixed complex Rh-B-1 as a highly air-stable radical. The structures of B-1 and Rh-B-1 were determined by single-crystal X-ray diffractions, and the antiaromatic or radical character was identified by various spectroscopy evidence and theoretical calculations...
March 27, 2024: Chemistry: a European Journal
https://read.qxmd.com/read/38531718/an-atmospheric-water-harvesting-system-based-on-the-optimal-harvesting-window-design-for-worldwide-water-production
#2
JOURNAL ARTICLE
Qian Li, Zhao Shao, Qihong Zou, Quanwen Pan, Yao Zhao, Yaohui Feng, Wenwen Wang, Ruzhu Wang, Tianshu Ge
Atmospheric water harvesting (AWH) is a promising solution to the water shortage problem. Current sorption-based AWH (SAWH) systems seldom obtain both wide climatic adaptability and high energy efficiency due to the lack of thermodynamic optimization. To achieve the ideal harvesting circulation in SAWH systems, the "optimal harvesting window" (OHW) design based on thermodynamic analysis was first proposed and validated by our prototype. The "OHW" theory indicates the water production rate and energy efficiency could be improved by properly reducing the adsorption temperature...
March 9, 2024: Science Bulletin
https://read.qxmd.com/read/38530340/ozonolysis-of-2-methyl-2-pentenal-new-insights-from-master-equation-modeling
#3
JOURNAL ARTICLE
Najoua Derbel, Carmen Kalalian, Alexander Alijah, Struan H Robertson, Abdelkhaleq Chakir, Estelle Roth
Experimental and theoretical studies were carried out to investigate the ozonolysis of trans -2-methyl-2-pentenal. The experiments were conducted in atmospheric simulation chambers coupled to a Fourier transform infrared (FTIR) spectrometer and a gas chromatograph-mass spectrometer at room temperature and atmospheric pressure in the presence of an excess of cyclohexane in dry conditions (RH < 1%). The ozonolysis reaction was investigated theoretically from the results of accurate density functional (M06-2X) and ab initio [CCSD(T)] computations, employing the AVTZ basis set...
March 26, 2024: Journal of Physical Chemistry. A
https://read.qxmd.com/read/38526133/blood-volume-phenotypes-and-patient-sex-in-resistant-hypertension
#4
JOURNAL ARTICLE
Brendan J Carry, Wayne L Miller
The relationship of blood volume (BV) to systemic blood pressure (BP) is not well defined in resistant hypertension (RH). The goal of this study was to examine the extent to which systemic BP stratified by patient sex would impact BV phenotypes. A retrospective analysis of clinical and quantitative BV data was undertaken in a cohort of ambulatory patients with a history of controlled and uncontrolled RH. We analyzed 253 unique BVs with 54% of patients above goal BP of <150 mmHg. BV phenotypes were highly variable but no correlation of systolic BP to absolute BV or percentage deviation from normal volume was identified in either sex...
February 15, 2024: Journal of Hypertension
https://read.qxmd.com/read/38523363/prediction-of-the-antigenic-regions-in-eight-rhd-variants-identified-by-computational-biology
#5
JOURNAL ARTICLE
Rocio Trueba-Gómez, Fany Rosenfeld-Mann, Higinio Estrada-Juárez
BACKGROUND AND OBJECTIVES: Changes in RHD generate variations in protein structure that lead to antigenic variants. The classical model divides them into quantitative (weak and Del) and qualitative (partial D). There are two types of protein antigens: linear and conformational. Computational biology analyses the theoretical assembly of tertiary protein structures and allows us to identify the 'topological' differences between isoforms. Our aim was to determine the theoretical antigenic differences between weak RhD variants compared with normal RhD based on structural analysis using bioinformatic techniques...
March 24, 2024: Vox Sanguinis
https://read.qxmd.com/read/38523298/evaluation-of-therapeutic-efficacy-of-emustil-drops-for-ocular-discomfort-and-tear-film-osmolarity-using-different-treatment-management-modes-under-dry-environmental-conditions
#6
JOURNAL ARTICLE
Ali Abusharha, E Ian Pearce, Tayyaba Afsar, Suhail Razak
BACKGROUND: We aimed to check the efficacy of Emustil (oil in water emulsion) drops on tear film index and ocular surface dynamics in dry environments through protection and relief treatment modalities. METHODS: The subjects were exposed to a dry environment using a Controlled Environment Chamber (CEC) where the relative humidity (RH) was 5% and the temperature was 21 °C and screened for ocular symptoms, tear osmolarity, ocular surface temperature (OST) and tear production using ocular Surface Disease Index questionnaire (OSDI), OcuSense TearLab Osmometer, FLIR System ThermaCAM P620 and Schirmer strips/phenol red test respectively...
March 25, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38509839/total-synthesis-of-the-euphorbia-diterpenoid-pepluacetal
#7
JOURNAL ARTICLE
Meng Liu, Chuanhua Wu, Xingang Xie, Huilin Li, Xuegong She
The first total synthesis of the Euphorbia diterpenoid pepluacetal is disclosed in both racemic and chiral fashions. The synthesis strategically relies on a photo-induced Wolff rearrangement/lactonization cascade (WRLC) reaction to access the cyclobutane moiety, a ring-closing metathesis/cyclopropanation sequence to rapidly forge the 7-3 bicyclic system, and a late-stage Rh-catalyzed transannular carbenoid insertion to C(sp3)-H bond followed by a Baeyer-Villiger oxidation and ring-opening manipulations to install the side chain...
March 21, 2024: Angewandte Chemie
https://read.qxmd.com/read/38498516/rapid-visual-detection-of-peronophythora-litchii-on-lychees-using-recombinase-polymerase-amplification-combined-with-lateral-flow-assay-based-on-the-unique-target-gene-pl_101565
#8
JOURNAL ARTICLE
Rongbo Wang, Benjin Li, Mingyue Shi, Yumei Zhao, Jinlong Lin, Qinghe Chen, Peiqing Liu
Downy blight, caused by Peronophythora litchii , is a destructive disease that impacts lychee fruit throughout the pre-harvest, post-harvest, and transportation phases. Therefore, the prompt and precise identification of P. litchii is crucial for the effective management of the disease. A novel gene encoding a Rh-type ammonium transporter, Pl_101565 , was identified in P. litchii through bioinformatic analysis in this study. Based on this gene, a coupled recombinase polymerase amplification-lateral flow (RPA-LF) assay for the rapid visual detection of P...
February 18, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38497619/construction-of-seven-membered-oxacycles-using-a-rh-i-catalyzed-cascade-c-c-formation-cleavage-of-cyclobutenol-derivatives
#9
JOURNAL ARTICLE
Jin Su Ham, Mina Son, Christina G Na, Bohyun Park, Mu-Hyun Baik, Richmond Sarpong
Herein, we describe the synthesis of substituted oxepane derivatives through the skeletal remodeling of 4-hydroxy-2-cyclobutenones, which are readily prepared from commercially available dialkyl squarates upon their reaction with acrylonitrile. Mechanistically, a Rh(I)-catalyzed C-C bond formation and cleavage cascade is proposed. Specifically, a fused [3.2.0] bicycle is proposed to form from dialkyl squarate-derived cyclobutenols via an unusual Rh(I)-catalyzed intermolecular oxa-Michael addition of a tertiary alcohol with acrylonitrile, followed by an intramolecular conjugate addition/migratory insertion...
March 18, 2024: Journal of Organic Chemistry
https://read.qxmd.com/read/38494079/dna-reference-reagents-for-genotyping-rh-variants
#10
JOURNAL ARTICLE
Emilia Sippert, Evgeniya Volkova, Meagan Rippee-Brooks, Gregory A Denomme, Willy A Flegel, Christine Lee, Richardae Araojo, Orieji Illoh, Zhugong Liu, Maria Rios
Patients who carry RH blood group variants may develop Rh alloantibodies requiring matched red cell transfusions. Serologic reagents for Rh variants often fail to specifically identify variant Rh antigens and are in limited supply. Therefore, red cell genotyping assays are essential for managing transfusions in patients with clinically relevant Rh variants. Well-characterized DNA reference reagents are needed to ensure quality and accuracy of the molecular tests. Eight lyophilized DNA reference reagents, representing 21 polymorphisms in RHD and RHCE, were produced from an existing repository of immortalized B-lymphoblastoid cell lines at CBER/U...
March 15, 2024: Journal of Molecular Diagnostics: JMD
https://read.qxmd.com/read/38493177/application-of-3-2-factorial-design-for-loratadine-loaded-nanosponge-in-topical-gel-formulation-comprehensive-in-vitro-and-ex-vivo-evaluations
#11
JOURNAL ARTICLE
Durgaramani Sivadasan, Krishnaraju Venkatesan, Jamal Moideen Muthu Mohamed, Saud Alqahtani, Yahya I Asiri, Mennatullah M Faisal, Adel Ehab Ibrahim, Yahya Bin Abdullah Alrashdi, Farid Menaa, Sami El Deeb
Loratadine (LoR) is a highly lipophilic and practically insoluble in water, hence having a low oral bioavailability. As it is formulated as topical gel, it competitively binds with the receptors, thus reducing the side-effects. The objective of this study was to prepare LoR loaded nanosponge (LoR-NS) in gel for topical delivery. Nine different formulations of emulsion were prepared by solvent evaporation method with polyvinyl alcohol (PVA), ethyl cellulose (EC), and dichloromethane (DCM). Based on 32 Full Factorial Design (FFD), optimization was carried out by varying the concentration of LOR:EC ratio and stirring rate...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38487289/postharvest-handling-of-ethylene-with-oxidative-and-absorptive-means
#12
REVIEW
Sunil Kumar, Ramesh Kumar, Bhushan R Bibwe, Prerna Nath, Rajesh K Singh, Shiwani Mandhania, Ajay Pal, Ramesh Soni, Anuj Kumar
UNLABELLED: Fruit ripening is an unfolding of a series of genetically-programmed modifications and tend to be highly orchestrated irrevocable phenomenon mediated by ethylene. Phytohormone ethylene also leads to over-ripening, senescence, loss of texture, microbial attack, reduced post-harvest life and other associated problems during storage and transportation of fruits. Its harmful impacts on fresh fruits, vegetables, and ornamentals result in substantial product losses even up to 80%...
May 2024: Journal of Food Science and Technology
https://read.qxmd.com/read/38475336/poly-ester-imide-s-with-low-linear-coefficients-of-thermal-expansion-and-low-water-uptake-vii-a-strategy-to-achieve-ultra-low-dissipation-factors-at-10-ghz
#13
JOURNAL ARTICLE
Masatoshi Hasegawa, Taro Fukuda, Junichi Ishii
In this study, a series of ester-linked tetracarboxylic dianhydrides (TCDAs) with 2,6-naphthalene-containing longitudinally extended structures consisting of different numbers of aromatic rings ( N Ar = 6-8) was synthesized to obtain novel modified polyimides, poly(ester imide)s (PEsIs). These TCDAs were fully compatible with the conventional manufacturing processes of conventional polyimide (PI) systems. As an example, the PEsI film obtained from the ester-linked TCDA ( N Ar = 8) and an ester-linked diamine achieved unprecedented outstanding dielectric properties without the support of fluorinated monomers, specifically an ultra-low dissipation factor (tan δ ) of 0...
February 28, 2024: Polymers
https://read.qxmd.com/read/38474607/spectrophotometric-and-chromatographic-assessment-of-total-polyphenol-and-flavonoid-content-in-rhododendron-tomentosum-extracts-and-their-antioxidant-and-antimicrobial-activity
#14
JOURNAL ARTICLE
Halyna Kukhtenko, Nataliia Bevz, Yulian Konechnyi, Oleksandr Kukhtenko, Izabela Jasicka-Misiak
In the literature, the chemical composition of Rhododendron tomentosum is mainly represented by the study of isoprenoid compounds of essential oil. In contrast, the study of the content of flavonoids will contribute to the expansion of pharmacological action and the use of the medicinal plant for medical purposes. The paper deals with the technology of extracts from Rh. tomentosum shoots using ethanol of various concentrations and purified water as an extractant. Extracts from Rh. tomentosum were obtained by a modified method that combined the effects of ultrasound and temperature to maximize the extraction of biologically active substances from the raw material...
February 29, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38463953/functional-partitioning-of-sentence-processing-and-emotional-prosody-in-the-right-perisylvian-cortex-after-perinatal-stroke
#15
Kelly C Martin, Anna Seydell-Greenwald, Peter E Turkeltaub, Catherine E Chambers, William D Gaillard, Elissa L Newport
In healthy adults different language abilities-sentence processing versus emotional prosody-are supported by the left (LH) versus the right hemisphere (RH), respectively. However, after LH stroke in infancy, RH regions support both abilities with normal outcomes. We investigated how these abilities co-exist in RH regions after LH perinatal stroke by evaluating the overlap in the activation between two fMRI tasks that probed auditory sentence processing and emotional prosody processing. We compared the overlap for these two functions in the RH of individuals with perinatal stroke with the symmetry of these functions in the LH and RH of their healthy siblings...
February 22, 2024: Research Square
https://read.qxmd.com/read/38462300/grazing-system-and-hyalomma-marginatum-tick-infestation-in-cattle-with-high-prevalence-of-sfg-rickettsia-spp
#16
JOURNAL ARTICLE
Kassim Abdullahi Jimale, Valeria Zeni, Alice Ripamonti, Angelo Canale, Marcello Mele, Giovanni Benelli, Domenico Otranto
Tick-borne diseases (TBDs) represent a significant portion of infectious diseases of global public health interest. In Italy, knowledge about the occurrence of tick-borne pathogens (TBPs) in ticks parasitizing cattle is scarce. In this research, we focused on ticks infesting Maremmana cattle grazing in open pasture and silvopasture systems. After being morphologically identified, ticks were molecularly tested for the presence of pathogens of the genus Rickettsia. Of the 794 ticks detected, 117 were collected, being the majority Hyalomma marginatum (72...
April 2024: Veterinary Parasitology (Amsterdam)
https://read.qxmd.com/read/38459688/formulation-and-optimisation-of-ozenoxacin-topical-nano-emulgel-including-a-comprehensive-methodology-to-qualify-and-validate-the-critical-parameters-of-an-in-vitro-release-test-method-and-ex-vivo-permeation-test
#17
JOURNAL ARTICLE
Amarnath Reddy Ramireddy, Dilip Kumar Behara
Objective: The purpose of this study was to formulate, optimise Ozenoxacin topical nano-emulsion using factorial design followed by to prepare and evaluate nano-emulgel using validated In-Vitro Release Testing (IVRT) technique for determination of Ozenoxacin release rate along with Ex-Vivo Permeation Testing (EVPT). Significance: Nano-emulgel are a proven delivery system for poorly soluble substances works by enhancing the solubility and bioavailability. Factorial design provides a systematic and efficient means to study the effect of multiple factors on responses...
March 8, 2024: Drug Development and Industrial Pharmacy
https://read.qxmd.com/read/38457869/clinical-effects-of-equine-assisted-therapeutic-exercises-in-static-and-dynamic-balance-of-children-with-cerebral-palsy
#18
JOURNAL ARTICLE
A N Stergiou, D N Varvarousis, S Mattila-Rautiainen, M Tzoufi, S Doulgeri, A Ploumis
OBJECTIVE: To evaluate the efficacy of equine-assisted therapy for the static and dynamic balance in the rehabilitation of children and adolescents with cerebral palsy maintaining obtained improvement 8-weeks after the end of the intervention. METHOD: The study lasted 28 weeks, of which the intervention lasted 12 weeks. Measurements were taken before, in the middle, after the end of the intervention and follow-up after 12 weeks. Paediatric Balance Scale and dynamic plate were used to evaluate the balance...
March 7, 2024: Rehabilitación
https://read.qxmd.com/read/38457026/dynamic-intervention-to-enhance-the-stability-of-pegylated-ibrutinib-loaded-lipidic-nano-vesicular-systems-transitioning-from-colloidal-dispersion-to-lyophilized-product
#19
JOURNAL ARTICLE
Kanan Panchal, Akhila Reddy, Rishi Paliwal, Akash Chaurasiya
Liposomes being a promising colloidal system facilitates delivery of drugs with limited pharmacokinetic properties to achieve desirable clinical applications. However, development of a stable liposomal system is always challenging due to multiple complexities involved. Aqueous instability of liposomes and impact of various process and formulation parameters can lead to serious alteration of its therapeutic performance. In the proposed work, the authors aim to develop stable Ibrutinib-loaded liposomes using lyophilization and Quality-by-Design and assess their long-term stability...
March 8, 2024: Drug Delivery and Translational Research
https://read.qxmd.com/read/38456513/resistant-hypertension
#20
JOURNAL ARTICLE
Farnoosh Shariati, Nitin Tandan, Carl J Lavie
PURPOSE OF REVIEW: Resistant hypertension (RH) is characterized by persistently elevated blood pressure despite the concurrent use of three antihypertensive medications, including a diuretic, at optimal doses. This clinical phenomenon poses a significant burden on healthcare systems worldwide due to its association with increased cardiovascular disease morbidity and mortality. RECENT FINDINGS: Ongoing studies on device-based treatment of RH, with aim to reduce sympathetic nervous system outflow, have shown promising evidence in management of RH which may in turn decrease the incidence of composite cardiovascular outcome faced by the affected population...
March 5, 2024: Current Opinion in Cardiology
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