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https://www.readbyqxmd.com/read/27896569/anti-pituitary-antibodies-against-corticotrophs-in-igg4-related-hypophysitis
#1
Naoko Iwata, Shintaro Iwama, Yoshihisa Sugimura, Yoshinori Yasuda, Kohtaro Nakashima, Seiji Takeuchi, Daisuke Hagiwara, Yoshihiro Ito, Hidetaka Suga, Motomitsu Goto, Ryoichi Banno, Patrizio Caturegli, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Arima
PURPOSE: IgG4-related disease is a systemic inflammatory disease characterized by infiltration of IgG4-positive plasma cells into multiple organs, including the pituitary gland. Autoimmunity is thought to be involved in the pathogenesis of IgG4-related disease. The diagnosis of IgG4-related hypophysitis (IgG4-RH) is difficult because its clinical features, such as pituitary swelling and hypopituitarism, are similar to those of other pituitary diseases, including lymphocytic hypophysitis and sellar/suprasellar tumors...
November 28, 2016: Pituitary
https://www.readbyqxmd.com/read/27895876/assessment-of-mean-glandular-dose-in-mammography-system-with-different-anode-filter-combinations-using-mcnp-code
#2
Lida Gholamkar, Ali Asghar Mowlavi, Mahdi Sadeghi, Mitra Athari
BACKGROUND: X-ray mammography is one of the general methods for early detection of breast cancer. Since glandular tissue in the breast is sensitive to radiation and it increases the risk of cancer, the given dose to the patient is very important in mammography. OBJECTIVES: The aim of this study was to determine the average absorbed dose of X-ray radiation in the glandular tissue of the breast during mammography examinations as well as investigating factors that influence the mean glandular dose (MGD)...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27894696/complex-analysis-of-concentrated-antibody-gold-nanoparticle-conjugates-mixtures-using-asymmetric-flow-field-flow-fractionation
#3
Irina V Safenkova, Elvira S Slutskaya, Vasily G Panferov, Anatoly V Zherdev, Boris B Dzantiev
Conjugates of gold nanoparticles (GNPs) with antibodies are powerful analytical tools. It is crucial to know the conjugates' state in both the concentrated and mixed solutions used in analytical systems. Herein, we have applied asymmetrical flow field-flow fractionation (AF4) to identify the conjugates' state. The influence of a conjugate's composition and concentration on aggregation was studied in a true analytical solution (a concentrated mixture with stabilizing components). GNPs with an average diameter of 15...
November 22, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27893356/single-stranded-dna-aptamer-targeting-and-neutralization-of-anti-d-alloantibody-a-potential-therapeutic-strategy-for-haemolytic-diseases-caused-by-rhesus-alloantibody
#4
Yinze Zhang, Fan Wu, Manni Wang, Naibao Zhuang, Huayou Zhou, Hua Xu
BACKGROUND: Rhesus (Rh) D antigen is the most important antigen in the Rh blood group system because of its strong immunogenicity. When RhD-negative individuals are exposed to RhD-positive blood, they may produce anti-D alloantibody, potentially resulting in delayed haemolytic transfusion reactions and Rh haemolytic disease of the foetus and newborn, which are difficult to treat. Inhibition of the binding of anti-D antibody with RhD antigens on the surface of red blood cells may effectively prevent immune haemolytic diseases...
November 11, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27893352/prevalence-of-antibodies-to-a-new-histo-blood-system-the-fors-system
#5
Carlos Jesus, Camilla Hesse, Clara Rocha, Nádia Osório, Ana Valado, Armando Caseiro, António Gabriel, Lola Svensson, Ali-Reza Moslemi, Wafa Abu Siba, Mahmoud A Srour, Cristina Pereira, Jorge Tomaz, Paulo Teixeira, Fernando Mendes
BACKGROUND: In 1987, three unrelated English families were reported with a putative blood subgroup called Apae. Swedish researchers later found evidence leading to abolishment of the Apae subgroup and establishment instead of the FORS blood group system (System 31 - ISBT, 2012). It is important to know the prevalence of antibodies in order to make the best decisions in transfusion medicine. Cells expressing the Forssman saccharide, such as sheep erythrocytes, are needed to detect the anti-Forssman antibody...
October 24, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27890595/the-formation-and-physical-stability-of-two-phase-solid-dispersion-systems-of-indomethacin-in-supercooled-molten-mixtures-with-different-matrix-formers
#6
Kristian Semjonov, Karin Kogermann, Ivo Laidmäe, Osmo Antikainen, Clare J Strachan, Henrik Ehlers, Jouko Yliruusi, Jyrki Heinämäki
Amorphous solid dispersions (SDs) are a promising approach to improve the dissolution rate of and oral bioavailability of poorly water-soluble drugs. In some cases multi-phase, instead of single-phase, SD systems with amorphous drug are obtained. While it is widely assumed that one-phase amorphous systems are desirable, two-phase systems may still potentially exhibit enhanced stability and dissolution advantages over undispersed systems. The objective of the present study was to understand the solid-state properties of two-phase SDs with amorphous drug and their relation to physical stability...
November 23, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27878165/chemoselective-hydrogenation-of-arenes-by-pvp-supported-rh-nanoparticles
#7
Mahmoud Ibrahim, Raju Poreddy, Karine Philippot, Anders Riisager, Eduardo J Garcia-Suarez
Polyvinylpyrrolidone-stabilized Rh nanoparticles (RhNPs/PVP) of ca. 2.2 nm in size were prepared by the hydrogenation of the organometallic complex [Rh(η(3)-C3H5)3] in the presence of PVP and evaluated as a catalyst in the hydrogenation of a series of arene substrates as well as levulinic acid and methyl levulinate. The catalyst showed excellent activity and selectivity towards aromatic ring hydrogenation compared to other reported transition metal-based catalysts under mild reaction conditions (room temperature and 1 bar H2)...
November 23, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27871991/tumor-targeted-micelle-forming-block-copolymers-for-overcoming-of-multidrug-resistance
#8
Alena Braunová, Libor Kostka, Ladislav Sivák, Lucie Cuchalová, Zuzana Hvězdová, Richard Laga, Sergey Filippov, Peter Černoch, Michal Pechar, Olga Janoušková, Milada Šírová, Tomáš Etrych
New amphiphilic diblock polymer nanotherapeutics serving simultaneously as a drug delivery system and an inhibitor of multidrug resistance were designed, synthesized, and evaluated for their physico-chemical and biological characteristics. The amphiphilic character of the diblock polymer, containing a hydrophilic block based on the N-(2-hydroxypropyl)methacrylamide copolymer and a hydrophobic poly(propylene oxide) block (PPO), caused self-assembly into polymer micelles with an increased hydrodynamic radius (Rh of approximately 15nm) in aqueous solutions...
November 18, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27863769/erratum-to-frequencies-of-polymorphisms-of-rh-kell-kidd-duffy-and-diego-systems-of-santa-catarina-southern-brazil-rev-bras-hematol-hemoter-2016-38-3-199-205
#9
Daiane Cobianchi Costa, Alessandra Arruda Schinaider, Thais Mattos Santos, Everaldo José Schörner, Daniel Simon, Sharbel Weidner Maluf, Ana Carolina Rabello de Moraes, Maria Claudia Silva Silva
No abstract text is available yet for this article.
October 2016: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/27829895/experimental-and-theoretical-investigations-on-the-high-electron-donor-character-of-pyrido-annelated-n-heterocyclic-carbenes
#10
Michael Nonnenmacher, Dominik M Buck, Doris Kunz
Rh(CO)2Cl(NHC) complexes of dipyrido-annelated N-heterocyclic carbenes were prepared. From the C-H coupling constant of the respective imidazolium salts and the N-C-N angle of the N-heterocyclic carbene (NHC), a weaker σ-donor character than that of typical unsaturated NHCs is expected. However, the IR stretching frequencies of their Rh(CO)2Cl complexes suggest an electron-donor character even stronger than that of saturated NHCs. We ascribe this to the extremely weak π-acceptor character of the dipyrido-annelated NHCs caused by the conjugated 14 πe(-) system that thus allows for an enhanced Rh-CO backbonding...
2016: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27812335/rapid-hplc-quantification-approach-for-detection-of-active-constituents-in-modern-combinatorial-formula-san-huang-xie-xin-tang-shxxt
#11
Tung-Ying Wu, Fang-Rong Chang, Jing-Ru Liou, I-Wen Lo, Tang-Chia Chung, Li-Yao Lee, Chun-Chen Chi, Ying-Chi Du, Man-Hon Wong, Suh-Hang Hank Juo, Chun-Chen Lee, Yang-Chang Wu
San-Huang-Xie-Xin-Tang (SHXXT), one of the most important traditional Chinese medicinal formulas, is comprised by three herbal medicines, the rhizome of Rheum officinale [or Rheum tanguticum (Polygonaceae) (Dahuang in Chinese)], the root of Scutellaria baicalensis (Labiatae) (Huangqin in Chinese), and the rhizome of Coptis chinensis (Ranunculaceae) (Huanglian in Chinese) in the ratios of 2:1:1 or 1:1:1. This study is aimed to quantitate and qualify of SHXXT, by a rapid, convenient, and effective HPLC-PDA approach associated with LC-MS technique...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27812263/clinical-significance-of-rare-maternal-anti-jk-a-antibody
#12
Kshitija Mittal, Tanvi Sood, Naveen Bansal, Ravneet Kaur Bedi, Paramjit Kaur, Gagandeep Kaur
We hereby report a rare case of HDFN because of antibody to Kidd (Jk) blood group system-anti Jk(a). An EDTA sample of a baby along with mother's sample was received in the Department for Direct Antiglobulin Test (DAT) alongwith blood requisition for double volume exchange transfusion. On blood grouping, baby's and mother's blood group was found to be B Rh D positive. DAT with polyspecific anti human globulin (AHG) was positive. Screening of mother's serum for irregular antibodies showed anti-Jk(a) antibody...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27792349/relay-rh-ii-pd-0-dual-catalysis-selective-construction-of-cyclic-all-quaternary-carbon-centers
#13
Zi-Sheng Chen, Xiao-Yan Huang, Jin-Ming Gao, Kegong Ji
A novel relay Rh(II)/Pd(0) dual catalysis strategy that promotes the divergent reaction of α-diazo-carbonyl compounds with allylic carboxylates for the selective construction of cyclic all-quaternary carbon centers has been developed. This binary catalyst system rendered domino C-H insertion/allylic alkylation process under mild conditions. Remarkably, the domino catalytic reaction shows good selectivity and excellent tolerance to various functionalities and is operationally simple.
October 28, 2016: Organic Letters
https://www.readbyqxmd.com/read/27791066/mixing-of-secondary-organic-aerosols-versus-relative-humidity
#14
Qing Ye, Ellis Shipley Robinson, Xiang Ding, Penglin Ye, Ryan C Sullivan, Neil M Donahue
Atmospheric aerosols exert a substantial influence on climate, ecosystems, visibility, and human health. Although secondary organic aerosols (SOA) dominate fine-particle mass, they comprise myriad compounds with uncertain sources, chemistry, and interactions. SOA formation involves absorption of vapors into particles, either because gas-phase chemistry produces low-volatility or semivolatile products that partition into particles or because more-volatile organics enter particles and react to form lower-volatility products...
October 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27791063/lability-of-secondary-organic-particulate-matter
#15
Pengfei Liu, Yong Jie Li, Yan Wang, Mary K Gilles, Rahul A Zaveri, Allan K Bertram, Scot T Martin
The energy flows in Earth's natural and modified climate systems are strongly influenced by the concentrations of atmospheric particulate matter (PM). For predictions of concentration, equilibrium partitioning of semivolatile organic compounds (SVOCs) between organic PM and the surrounding vapor has widely been assumed, yet recent observations show that organic PM can be semisolid or solid for some atmospheric conditions, possibly suggesting that SVOC uptake and release can be slow enough that equilibrium does not prevail on timescales relevant to atmospheric processes...
October 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27785399/von-hippel-lindau-disease-the-clinical-manifestations-and-genetic-analysis-results-of-two-cases-from-a-single-family
#16
S Kinyas, S A Ozal, H Guclu, V Gurlu, H Esgin, H Gurkan
von Hippel-Lindau (VHL) disease is an autosomal dominant inherited multi systemic cancer syndrome that is classically associated with neoplasms in multiple organs, and caused by mutations in the VHL gene on chromosome 3p25-p26. Retinal hemangioblastoma (RH) is the most frequent and the earliest clinical sign of the disease, which is seen in 40.0-60.0% of patients. In recent years, studies of patients with VHL tried to put forward the relationship between genotype and phenotype. In this study, two VHL cases in the same family with clinical findings and genetic analysis results are presented...
December 1, 2015: Balkan Journal of Medical Genetics: BJMG
https://www.readbyqxmd.com/read/27784397/-significance-and-clinical-application-of-the-establishment-of-rhd-c-c-e-e-blood-group-base-in-chinese-nanyang-city
#17
Hai-Yun Li, Cong-Yuan Cheng
OBJECTIVE: To understand the regularity of Rh blood typing of valunteary blood donors in Chinese Nanyang city, and to estabbish a Rh DC/c/E/e antigen negative donor base so as to provide the help for clinical emergent blood transfusion to patients and ensure the safety of blood transfusion. METHODS: The Rh D blood group of blood samples from 81462 voluntary blood donors in Chinese Nanyang city in 2014 was identified by serologic method; after first screening and confirmation, the RhE/e/C/c typing of Rh D negative samples was performed; the detailed infornation of donors was registered seriously by using unified creteria; the data base and base in kind of RhE/e/C/c types of valuntary donors were established by means of compater-mamayement system...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27770530/some-clinically-important-erythrocyte-blood-group-antigens-in-donors
#18
I Tsintsadze, T Gorgoshadze, S Donskov, L Akhvlediani, M Nagervadze
The distribution of erythrocyte blood group antigens was evaluated among 656 donors; samples were provided by the diagnostic laboratory "Medina" Ltd Health Centre of Batumi. Lab analysis of the sample was conducted by the immunogenetics laboratory at Batumi Shota Rustaveli State University. The frequency of the ABO allele system in donors was as follows: r (0.70), q (0.23), p (0.07). The distribution of Rhesus (Rh) factor in the donor population was as follows: Rh(-) was found among 16.3±1.43% of investigated donors; the Rh(+) phenotype was found in 83...
September 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27762564/active-and-recyclable-catalytic-synthesis-of-indoles-by-reductive-cyclization-of-2-2-nitroaryl-acetonitriles-in-the-presence-of-co-rh-heterobimetallic-nanoparticles-with-atmospheric-hydrogen-under-mild-conditions
#19
Isaac Choi, Hyunho Chung, Jang Won Park, Young Keun Chung
A cobalt-rhodium heterobimetallic nanoparticle-catalyzed reductive cyclization of 2-(2-nitroaryl)acetonitriles to indoles has been achieved. The tandem reaction proceeds without any additives under the mild conditions (1 atm H2 and 25 °C). This procedure could be scaled up to the gram scale. The catalytic system is significantly stable under these reaction conditions and could be reused more than ten times without loss of catalytic activity.
October 20, 2016: Organic Letters
https://www.readbyqxmd.com/read/27757422/quasi-particle-interference-of-heavy-fermions-in-resonant-x-ray-scattering
#20
András Gyenis, Eduardo H da Silva Neto, Ronny Sutarto, Enrico Schierle, Feizhou He, Eugen Weschke, Mariam Kavai, Ryan E Baumbach, Joe D Thompson, Eric D Bauer, Zachary Fisk, Andrea Damascelli, Ali Yazdani, Pegor Aynajian
Resonant x-ray scattering (RXS) has recently become an increasingly important tool for the study of ordering phenomena in correlated electron systems. Yet, the interpretation of RXS experiments remains theoretically challenging because of the complexity of the RXS cross section. Central to this debate is the recent proposal that impurity-induced Friedel oscillations, akin to quasi-particle interference signals observed with a scanning tunneling microscope (STM), can lead to scattering peaks in RXS experiments...
October 2016: Science Advances
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