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https://www.readbyqxmd.com/read/28070829/functional-analysis-of-kif20a-a-potential-immunotherapeutic-target-for-glioma
#1
Katsuya Saito, Shigeki Ohta, Yutaka Kawakami, Kazunari Yoshida, Masahiro Toda
Kinesin family member 20A (KIF20A), an ideal cancer-testis antigen, was reported to be a promising immunotherapeutic target for pancreatic cancers. Clinical trials of KIF20A peptide vaccine immunotherapy have been conducted against pancreatic cancers. To demonstrate the efficacy of KIF20A as a candidate molecular target for gliomas, we analyzed the expression and function of KIF20A in gliomas. Western blot and quantitative PCR analyses showed that KIF20A expression in glioma cell lines and glioma tissues was high compared with that found in a normal brain...
January 9, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28045669/long-term-outcomes-of-successful-endovascular-therapy-via-the-retrograde-approach-for-below-the-knee-chronic-total-occlusion-in-patients-with-critical-limb-ischemia-after-a-failed-antegrade-approach
#2
Junya Matsumi, Takuma Takada, Noriaki Moriyama, Tomoki Ochiai, Kazuki Tobita, Koki Shishido, Kazuya Sugitatsu, Shingo Mizuno, Futoshi Yamanaka, Masato Murakami, Yutaka Tanaka, Saeko Takahashi, Takeshi Akasaka, Shigeru Saito
OBJECTIVE: This study evaluated long-term results following successful endovascular therapy (EVT) for chronic total occlusion (CTO) below the knee (BTK) using the retrograde approach after a failed antegrade approach. METHODS: Nineteen patients (19 limbs) with critical limb ischemia (CLI) who underwent successful EVT for BTK-CTO using the retrograde approach after a failed antegrade approach during 2010-2014 were studied. RESULTS: Mean duration of the follow-up period was 25...
January 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28040440/persistent-bioresorbable-vascular-scaffold-by-optical-coherence-tomography-imaging-at-5-years
#3
Noriaki Moriyama, Koki Shishido, Kazuki Tobita, Takuma Takada, Tomoki Ochiai, Saori Tsukuda, Futoshi Yamanaka, Kazuya Sugitatsu, Shingo Mizuno, Yutaka Tanaka, Masato Murakami, Junya Matsumi, Saeko Takahashi, Takeshi Akasaka, Shigeru Saito
No abstract text is available yet for this article.
December 17, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28029606/lacunar-infarcts-rather-than-white-matter-hyperintensity-as-a-predictor-of-future-higher-level-functional-decline-the-ohasama-study
#4
Megumi Tsubota-Utsugi, Michihiro Satoh, Naoki Tomita, Azusa Hara, Takeo Kondo, Miki Hosaka, Sho Saito, Kei Asayama, Ryusuke Inoue, Mikio Hirano, Aya Hosokawa, Keiko Murakami, Takahisa Murakami, Hirohito Metoki, Masahiro Kikuya, Shin-Ichi Izumi, Yutaka Imai, Takayoshi Ohkubo
OBJECTIVE: We aimed to determine the associations between silent cerebrovascular lesions, characterized by lacunar infarcts and white matter hyperintensity, and future decline in higher level functional capacity in older community-dwelling adults. MATERIALS AND METHODS: For this observational study, we selected individuals from the general population of Ohasama, a rural Japanese community. Three hundred thirty-one participants who were free of functional decline at baseline and who were at least 60 years old underwent brain magnetic resonance imaging and answered a questionnaire on higher level functional capacity derived from the Tokyo Metropolitan Institute of Gerontology Index of Competence...
October 28, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28026087/oral-contraceptive-therapy-reduces-serum-relaxin-2-in-elite-female-athletes
#5
Sayaka Nose-Ogura, Osamu Yoshino, Kaori Yamada-Nomoto, Mariko Nakamura, Miyuki Harada, Michiko Dohi, Toru Okuwaki, Yutaka Osuga, Takashi Kawahara, Shigeru Saito
AIM: Recent investigations have demonstrated that athletes with high relaxin-2 levels have a high risk of anterior cruciate ligament injuries, while athletes taking oral contraceptives (OC) have low relaxin-2 levels. It has not yet been clarified whether taking OC reduces relaxin-2 levels. The purpose of this study was to investigate changes in relaxin-2 levels in athletes taking OC. METHODS: Levels of relaxin-2, estradiol, progesterone, luteinizing hormone and follicle-stimulating hormone were measured in serum samples (n = 183) from 106 elite female athletes...
December 27, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28005247/efficacy-and-safety-of-low-dose-capecitabine-plus-docetaxel-versus-single-agent-docetaxel-in-patients-with-anthracycline-pretreated-her2-negative-metastatic-breast-cancer-results-from-the-randomized-phase-iii-jo21095-trial
#6
Daigo Yamamoto, Nobuaki Sato, Yoshiaki Rai, Yutaka Yamamoto, Mitsue Saito, Hiroji Iwata, Norikazu Masuda, Shoji Oura, Junichiro Watanabe, Satoshi Hattori, Yoshimasa Matsuura, Katsumasa Kuroi
PURPOSE: The randomized phase III JO21095 trial compared the efficacy and safety of low-dose capecitabine plus docetaxel combination therapy (XT) versus single-agent administration of docetaxel in anthracycline-pretreated HER2-negative metastatic breast cancer. METHODS: Patients were randomized to either low-dose XT (capecitabine 825 mg/m(2) twice daily, days 1-14; docetaxel 60 mg/m(2), day 1 every 3 weeks) or docetaxel (70 mg/m(2), day 1 every 3 weeks). The primary objective was to demonstrate superior progression-free survival (PFS) with low-dose XT versus single-agent docetaxel...
December 22, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27993290/increased-levels-of-prostaglandin-e-major-urinary-metabolite-pge-mum-in-chronic-fibrosing-interstitial-pneumonia
#7
Tsugumi Horikiri, Hiromichi Hara, Nayuta Saito, Jun Araya, Naoki Takasaka, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Yutaka Yoshii, Hiroshi Wakui, Shunsuke Minagawa, Takeo Ishikawa, Kenichiro Shimizu, Takanori Numata, Seiji Arihiro, Yumi Kaneko, Katsutoshi Nakayama, Tomokazu Matsuura, Masaaki Matsuura, Mutsunori Fujiwara, Isao Okayasu, Satoru Ito, Kazuyoshi Kuwano
BACKGROUND: Dysregulation of the prostaglandin E2 (PGE2) signaling pathway has been implicated in interstitial pneumonia (IP) pathogenesis. Due to the unstable nature of PGE2, available detection methods may not precisely reflect PGE2 levels. We explored the clinical usefulness of measuring stable prostaglandin E-major urinary metabolite (PGE-MUM) with respect to pathogenesis and extent of chronic fibrosing IP (CFIP), including idiopathic pulmonary fibrosis (IPF), as PGE-MUM is reflective of systemic PGE2 production...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27943566/impact-of-androgen-deprivation-therapy-on-volume-reduction-and-lower-urinary-tract-symptoms-in-patients-with-prostate-cancer
#8
Satoshi Washino, Masaru Hirai, Kimitoshi Saito, Yutaka Kobayashi, Yoshiaki Arai, Tomoaki Miyagawa
OBJECTIVE: To evaluate the impact of androgen deprivation therapy (ADT) on prostate volume, lower urinary tract symptoms (LUTS), and LUTS-related quality of life (QOL) in patients with prostate cancer. METHODS: Patients with prostate cancer (PCa) were treated with goserelin and bicalutamide for 24 weeks. Changes in the total prostate volume (TPV), International Prostate Symptom Score (IPSS), and QOL score for urinary symptoms were assessed every 12 weeks. Of the 42 patients enrolled, 8 patients withdrew and 2 were excluded, so 32 patients were analyzed...
December 12, 2016: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/27938790/surveillance-after-endoscopic-and-surgical-resection-of-colorectal-cancer
#9
REVIEW
Masau Sekiguchi, Takahisa Matsuda, Yutaka Saito
With the increase in colorectal cancer burden, surveillance following endoscopic and surgical resection is an essential issue. The aim of surveillance programs is improvement of patient survival by early detection of residual tumor tissue or local recurrence, metachronous colorectal tumors, and metastases. Appropriate surveillance should be determined according to this risk of factors. In current guidelines, only surveillance colonoscopy is recommended after endoscopic resection of polyps with high-grade dysplasia, whereas intensive, multimodality surveillance using colonoscopy, radiological imaging and tumor marker measurements is recommended following surgical resection of invasive colorectal cancer...
December 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27934619/a-case-of-fulminant-type-1-diabetes-mellitus-with-a-precipitous-decrease-in-pancreatic-volume-induced-by-nivolumab-for-malignant-melanoma-analysis-of-hla-and-ctla-4-polymorphisms
#10
Kazushi Ishikawa, Tomoko Shono-Saito, Tomoko Yamate, Yoshitaka Kai, Takashi Sakai, Fumiaki Shimizu, Yasunari Yamada, Hiromu Mori, Shinsuke Noso, Hiroshi Ikegami, Hiroto Kojima, Hidenori Tanaka, Sakuhei Fujiwara, Yutaka Hatano
No abstract text is available yet for this article.
December 8, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27919194/total-knee-arthroplasty-improves-both-knee-function-and-disease-activity-in-patients-with-rheumatoid-arthritis
#11
Ken Kumagai, Kengo Harigane, Yoshihiro Kusayama, Taro Tezuka, Yutaka Inaba, Tomoyuki Saito
OBJECTIVE: This study evaluated the effect of TKA with capsulosynovectomy on disease activity and knee function in patients with RA. METHODS: Seventy-six RA patients who underwent primary TKA with more than two years of follow-up were retrospectively reviewed to assess postoperative knee function and disease activity. RESULTS: Postoperative knee function was significantly improved in all clinical scores, and maintained up to 24 months after surgery...
December 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27916776/favorable-clinical-outcomes-of-transcatheter-aortic-valve-implantation-in-japanese-patients%C3%A3-first-report-from-the-post-approval-k-tavi-registry
#12
Shinya Takimoto, Naritatsu Saito, Kenji Minakata, Shinichi Shirai, Akihiro Isotani, Yoshio Arai, Michiya Hanyu, Tatsuhiko Komiya, Takeshi Shimamoto, Tsuyoshi Goto, Yasushi Fuku, Natsuhiko Ehara, Yutaka Furukawa, Tadaaki Koyama, Atsuhi Nagasawa, Toshihiro Tamura, Makoto Miyake, Kazuo Yamanaka, Hisashi Sakaguchi, Koichiro Murata, Tomoya Onodera, Fumio Yamazaki, Masanao Nakai, Tomohiko Taniguchi, Ryuzo Sakata, Takeshi Kimura
BACKGROUND: Very limited data exist on the outcomes of transcatheter aortic valve implantation (TAVI) since Japanese marketing approval of the first TAVI device.Methods and Results:The Kyoto University-related hospital Transcatheter Aortic Valve Implantation (K-TAVI) registry includes prospectively collected data from 6 participating hospitals in Japan. We included 302 patients with severe aortic stenosis who underwent TAVI using the SAPIEN XT balloon-expandable valve via transfemoral (TF; n=203, 67%) or transapical (TA; n=99, 33%) approach between October 2013 and September 2015...
December 22, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27867814/the-assessment-of-myometrium-perfusion-in-patients-with-uterine-fibroid-by-arterial-spin-labeling-mri
#13
Nozomi Takahashi, Osamu Yoshino, Osamu Hiraike, Eriko Maeda, Masanobu Nakamura, Masaaki Hori, Miyuki Harada, Kaori Koga, Shigeru Saito, Tomoyuki Fujii, Yutaka Osuga
BACKGROUND: It has been suggested that an inadequate blood supply caused by uterine fibroids may lead to decreasing fertility. Therefore, a quantitative evaluation of blood flow in the uterus might be a good tool for infertility treatments. For the first step, the ability to perform arterial spin labeling (ASL)-MRI in pelvic organs was examined by measuring blood flow in the uterine muscle layer. RESULTS: Three normal volunteer women, seven patients with one uterine fibroid and four patients treated with GnRH analogue for uterine fibroids, were enrolled in this study...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27865193/different-clinical-outcomes-in-patients-with-asymptomatic-severe-aortic-stenosis-according-to-the-stage-classification-does-the-aortic-valve-area-matter
#14
Takeshi Kitai, Tomohiko Taniguchi, Takeshi Morimoto, Toshiaki Toyota, Chisato Izumi, Shuichiro Kaji, Kitae Kim, Naritatsu Saito, Kazuya Nagao, Tsukasa Inada, Eri Minamino-Muta, Takao Kato, Moriaki Inoko, Katsuhisa Ishii, Tadaaki Koyama, Ryuzo Sakata, Yutaka Furukawa, Takeshi Kimura
BACKGROUND: The ACC/AHA guidelines introduced a new classification of severe aortic stenosis (AS) mainly based on maximum jet velocity (Vmax) and mean pressure gradient (mPG), but not on aortic valve area (AVA). However, prognostic value of this new classification has not yet been fully evaluated. METHODS AND RESULTS: We studied 1512 patients with asymptomatic severe AS enrolled in the CURRENT AS registry in whom surgery was not initially planned. Patients were divided into 2 groups: Group 1 (N=122) comprised patients who met the recommendation for surgery; high-gradient (HG)-AS (Vmax≥4...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27835982/effectiveness-of-hepatoprotective-drugs-for-anti-tuberculosis-drug-induced-hepatotoxicity-a-retrospective-analysis
#15
Zenya Saito, Yugo Kaneko, Akira Kinoshita, Yusuke Kurita, Kyuto Odashima, Tsugumi Horikiri, Yutaka Yoshii, Aya Seki, Yoshitaka Seki, Hiroshi Takeda, Kazuyoshi Kuwano
BACKGROUND: The effectiveness of hepatoprotective drugs for DIH (drug induced hepatotoxicity) during tuberculosis treatment is not clear. We evaluated the effectiveness of hepatoprotective drugs by comparing the period until the normalization of hepatic enzymes between patients who were prescribed with the hepatoprotective drugs after DIH was occurred and patients who were not prescribed with the hepatoprotective drugs. METHODS: During 2006-2010, 389 patients with active tuberculosis were included in this study...
November 11, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27815008/the-distribution-of-impingement-region-in-cam-type-femoroacetabular-impingement-and-borderline-dysplasia-of-the-hip-with-or-without-cam-deformity-a-computer-simulation-study
#16
Naomi Kobayashi, Yutaka Inaba, So Kubota, So Nakamura, Taro Tezuka, Yohei Yukizawa, Hyonmin Choe, Tomoyuki Saito
PURPOSE: To identify the distribution of the impingement region in cam-type femoroacetabular impingement (FAI) or patients with borderline developmental dysplasia of the hip (DDH) using computer simulation analysis. METHODS: A total of 51 painful hip joints from 42 consecutive cases diagnosed as cam-type FAI (center edge [CE] angle ≥ 25°, alpha angle ≥ 55°) or borderline DDH (CE angle ≥ 20° and < 25°) with or without a cam deformity (alpha angle ≥ 55° or < 55°) were enrolled...
November 1, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27793921/investigation-of-bioequivalence-between-brand-name-and-generic-irinotecan-products
#17
Ken-Ichi Saito, Yutaka Inoue, Yoji Ikegami, Izumi Nanbo, Mari Onozuka, Kazumi Sano, Hisahiro Yoshida, Toshihiro Sakamoto, Emi Tatebayashi, Ken-Ichi Fujita, Yasutsuna Sasaki, Takaki Kitazawa
BACKGROUND/AIM: To investigate bioequivalence among generic and brand-name irinotecan products. MATERIALS AND METHODS: Products of Yakult and Daiichi-Sankyo (brand-name products), Sandoz, Nippon Kayaku, Taiho, and Sawai were compared with respect to their composition and antitumor activity. RESULTS: High-performance liquid chromatography demonstrated that related substances were within the acceptable range. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay revealed significant differences in cytotoxicity for four cancer cell lines among the products...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27779697/myofibroblast-distribution-is-associated-with-invasive-growth-types-of-colorectal-cancer
#18
Masafumi Takatsuna, Satoko Morohashi, Tadashi Yoshizawa, Hideaki Hirai, Toshihiro Haga, Rie Ota, Kensuke Saito, Yunyan Wu, Hiroko Seino, Yutaka Aoyagi, Shuji Terai, Hiroshi Kijima
Both the invasive growth types of colorectal cancer (CRC) and the number of myofibroblasts have been associated with histopathological factors such as lymph node and liver metastasis, and local recurrence. However, there are few studies, that have assessed the association between invasive growth type and myofibroblast distribution in CRC. We aimed to evaluate the relationship between the clinicopathological factors of CRC and two invasive growth types, the expanding and infiltrating types. We categorized 150 cases of pT3 CRC into the expanding and infiltrating types and measured the myofibroblast density of three histological layers: the submucosa (SM), the muscularis propria (MP) and the subserosa (SS)...
December 2016: Oncology Reports
https://www.readbyqxmd.com/read/27766701/alpha-7-nicotinic-acetylcholine-receptor-nachr-agonist-inhibits-the-development-of-endometriosis-by-regulating-inflammation
#19
Kaori Yamada-Nomoto, Osamu Yoshino, Ikumi Akiyama, Akemi Ushijima, Yosuke Ono, Tomoko Shima, Akitoshi Nakashima, Shusaku Hayashi, Makoto Kadowaki, Yutaka Osuga, Shigeru Saito
OBJECTIVE: We investigated α-7 nAchR expression in human peritoneal macrophages and examined whether activation of nAchR might be a new therapy for endometriosis. MATERIALS AND METHODS: Human peritoneal fluid mononuclear cells (PFMC) were stimulated with lipopolysaccharide (LPS) in the presence of α-7 nAChR agonists. In a murine endometriosis model, α-7 nAChR modulators were administered. RESULTS: Human PFMC expressed α-7 nAChR at the mRNA and protein levels...
December 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27751873/clinical-outcomes-and-prognostic-factors-in-gastric-cancer-patients-aged%C3%A2-%C3%A2-85-years-undergoing-endoscopic-submucosal%C3%A2-dissection
#20
Masau Sekiguchi, Ichiro Oda, Haruhisa Suzuki, Seiichiro Abe, Satoru Nonaka, Shigetaka Yoshinaga, Hirokazu Taniguchi, Shigeki Sekine, Yutaka Saito
BACKGROUND AND AIMS: Although the number of gastric cancer patients aged ≥85 years indicated for endoscopic submucosal dissection (ESD) has increased, little is known about the outcomes and prognostic factors. This study aimed to investigate the clinical outcomes and prognostic factors for overall survival (OS) of patients aged ≥85 years who underwent ESD for gastric cancer. METHODS: We retrospectively reviewed 108 patients aged ≥85 years with 149 gastric cancers treated by ESD between 1999 and 2014 at our institution...
October 15, 2016: Gastrointestinal Endoscopy
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