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https://www.readbyqxmd.com/read/29765561/a-pilot-study-of-peptide-vaccines-for-vegf-receptor-1-and-2-in-patients-with-recurrent-progressive-high-grade-glioma
#1
Shunsuke Shibao, Ryo Ueda, Katsuya Saito, Ryogo Kikuchi, Hideaki Nagashima, Atsuhiro Kojima, Hiroshi Kagami, Eriel Sandika Pareira, Hikaru Sasaki, Shinobu Noji, Yutaka Kawakami, Kazunari Yoshida, Masahiro Toda
Object: Early-phase clinical studies of glioma vaccines have shown feasibility and encouraging preliminary clinical activity. A vaccine that targets tumor angiogenesis factors in glioma microenvironment has not been reported. Therefore, we performed a pilot study to evaluate the safety and immunogenicity of a novel vaccination targeting tumor angiogenesis with synthetic peptides for vascular endothelial growth factor (VEGF) receptor epitopes in patients with recurrent/progressive high grade gliomas...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29735587/high-dose-versus-low-dose-pitavastatin-in-japanese-patients-with-stable-coronary-artery-disease-real-cad-a-randomized-superiority-trial
#2
Isao Taguchi, Satoshi Iimuro, Hiroshi Iwata, Hiroaki Takashima, Mitsuru Abe, Eisuke Amiya, Takanori Ogawa, Yukio Ozaki, Ichiro Sakuma, Yoshihisa Nakagawa, Kiyoshi Hibi, Takafumi Hiro, Yoshihiro Fukumoto, Seiji Hokimoto, Katsumi Miyauchi, Tsutomu Yamazaki, Hiroshi Ito, Yutaka Otsuji, Kazuo Kimura, Jun Takahashi, Atsushi Hirayama, Hiroyoshi Yokoi, Kazuo Kitagawa, Takao Urabe, Yasushi Okada, Yasuo Terayama, Kazunori Toyoda, Takehiko Nagao, Masayasu Matsumoto, Yasuo Ohashi, Tetsuji Kaneko, Retsu Fujita, Hiroshi Ohtsu, Hisao Ogawa, Hiroyuki Daida, Hiroaki Shimokawa, Yasushi Saito, Takeshi Kimura, Teruo Inoue, Masunori Matsuzaki, Ryozo Nagai
BACKGROUND: Current guidelines call for high-intensity statin therapy in patients with cardiovascular disease on the basis of several previous "more versus less statins" trials. However, no clear evidence for more versus less statins has been established in an Asian population. METHODS: In this prospective, multicenter, randomized, open-label, blinded end point study, 13 054 Japanese patients with stable coronary artery disease who achieved low-density lipoprotein cholesterol (LDL-C) <120 mg/dL during a run-in period (pitavastatin 1 mg/d) were randomized in a 1-to-1 fashion to high-dose (pitavastatin 4 mg/d; n=6526) or low-dose (pitavastatin 1 mg/d; n=6528) statin therapy...
May 8, 2018: Circulation
https://www.readbyqxmd.com/read/29713910/employment-status-and-termination-among-survivors-of-pediatric-brain-tumors-a-cross-sectional-survey
#3
Iori Sato, Akiko Higuchi, Takaaki Yanagisawa, Shiho Murayama, Toshihiro Kumabe, Kazuhiko Sugiyama, Akitake Mukasa, Nobuhito Saito, Yutaka Sawamura, Mizuhiko Terasaki, Soichiro Shibui, Jun Takahashi, Ryo Nishikawa, Yasushi Ishida, Kiyoko Kamibeppu
BACKGROUND: Some childhood cancer survivors experience employment difficulties. This study aimed to describe pediatric brain-tumor survivors' employment status. METHODS: A cross-sectional, observational study was conducted, with questionnaires distributed to 101 pediatric brain-tumor survivors (aged 15 years or older) and their attending physicians from nine institutions in Japan. We compared category and time-series histories for participants' first-time employment using national census information...
April 30, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29709915/hydrogen-peroxide-reducing-factor-released-by-pc12d-cells-increases-cell-tolerance-against-oxidative-stress
#4
Asami Muraishi, Emi Haneta, Yoshiro Saito, Yutaka Hitomi, Mamoru Sano, Noriko Noguchi
PC12D cells, a subline of rat adrenal pheochromocytoma PC12 cells, extend neurites rapidly in response to differentiation stimuli and are used to investigate the molecular mechanisms of neurite extension. In the present study, we found significant tolerance of PC12D cells against Parkinson's disease-related stimuli such as dopamine and 6-hydroxydopamine; this tolerance was significantly decreased by a change in the medium. Conditioned medium from PC12D cells induced tolerance against oxidative stress, which suggests that cytoprotective factor may be released by PC12D cells into the culture medium...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29700599/pilot-study-on-probe-based-confocal-laser-endomicroscopy-for-colorectal-neoplasms-an-initial-experience-in-japan
#5
Seiichiro Abe, Yutaka Saito, Yasuhiro Oono, Yusaku Tanaka, Taku Sakamoto, Masayoshi Yamada, Takeshi Nakajima, Takahisa Matsuda, Hiroaki Ikematsu, Tomonori Yano, Shigeki Sekine, Motohiro Kojima, Hidetsugu Yamagishi, Hiroyuki Kato
BACKGROUND: The aim of this pilot study is to investigate the diagnostic yield of probe-based confocal laser endomicroscopy (pCLE) in the evaluation of depth of invasion in colorectal lesions. METHODS: Patients with colorectal lesions eligible for either endoscopic treatment or surgery were enrolled in the study. Tumor's depth of invasion was classified as mucosal or slight submucosal (M-SM1) and deep submucosal invasion or deeper (SM2 or deeper). White light endoscopy (WLE), magnifying narrow band imaging (M-NBI), and magnifying chromoendoscopy (M-CE) were used to assess colorectal lesions, and pCLE was used to identify tumor's features related to SM2 or deeper...
April 26, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29699614/neoatherosclerosis-5-years-after-bioresorbable-vascular-scaffold-implantation
#6
Noriaki Moriyama, Koki Shishido, Yutaka Tanaka, Shohei Yokota, Takahiro Hayashi, Hirokazu Miyashita, Tatsuya Koike, Hiroaki Yokoyama, Takuma Takada, Takashi Nishimoto, Tomoki Ochiai, Kazuki Tobita, Futoshi Yamanaka, Shingo Mizuno, Masato Murakami, Saeko Takahashi, Shigeru Saito
BACKGROUND: Data regarding neoatherosclerosis after everolimus-eluting bioresorbable vascular scaffold (BVS) (ABSORB BVS Rev. 1.1, Abbott Vascular, Santa Clara, California) implantation are limited. OBJECTIVES: This study investigated the findings of neoatherosclerosis at 5 years after BVS 1.1 implantation by using multi-imaging modalities, including optical coherence tomography (OCT). METHODS: Patients included in the ABSORB EXTEND (ABSORB EXTEND Clinical Investigation) trial at Shonan Kamakura General Hospital underwent OCT at baseline after the index procedure and at 1 and 5 years...
May 1, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29682811/upregulation-of-hypothalamic-arginine-vasopressin-by-peripherally-administered-furosemide-in-transgenic-rats-expressing-arginine-vasopressin-enhanced-green-fluorescent-protein
#7
Hiromichi Ueno, Mitsuhiro Yoshimura, Kentaro Tanaka, Haruki Nishimura, Kazuaki Nishimura, Satomi Sonoda, Yasuhito Motojima, Reiko Saito, Takashi Maruyama, Tetsu Miyamoto, Ryota Serino, Masahito Tamura, Tatsushi Onaka, Yutaka Otsuji, Yoichi Ueta
Furosemide, which is used worldwide as a diuretic agent, inhibits sodium reabsorption in the Henle's loop, resulting in diuresis and natriuresis. Arginine vasopressin (AVP) is synthesized in the supraoptic nucleus (SON), paraventricular nucleus (PVN), and suprachiasmatic nucleus (SCN) of the hypothalamus. The synthesis AVP in the magnocellular neurons of SON and PVN physiologically regulated by plasma osmolality and blood volume and contributed water homeostasis by increasing water reabsorption in the collecting duct...
April 22, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29663558/usefulness-of-bcor-gene-mutation-as-a-prognostic-factor-in-acute-myeloid-leukemia-with-intermediate-cytogenetic-prognosis
#8
Kazuki Terada, Hiroki Yamaguchi, Toshimitsu Ueki, Kensuke Usuki, Yutaka Kobayashi, Kenji Tajika, Seiji Gomi, Saiko Kurosawa, Riho Saito, Yutaka Furuta, Keiki Miyadera, Taichiro Tokura, Atushi Marumo, Ikuko Omori, Masahiro Sakaguchi, Yusuke Fujiwara, Shunsuke Yui, Takeshi Ryotokuji, Kunihito Arai, Tomoaki Kitano, Satoshi Wakita, Takahiro Fukuda, Koiti Inokuchi
BCOR gene is a transcription regulatory factor that plays an essential role in normal hematopoiesis. The wider introduction of next-generation sequencing technology has led to reports in recent years of mutations in the BCOR gene in acute myeloid leukemia (AML), but the related clinical characteristics and prognosis are not sufficiently understood. We investigated the clinical characteristics and prognosis of 377 de novo AML cases with BCOR or BCORL1 mutation. BCOR or BCORL1 gene mutations were found in 28 cases (7...
April 16, 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29656581/the-jnet-classification-nbi-magnifying-endoscopic-classification-of-colorectal-tumors
#9
Yasushi Sano, Daizen Hirata, Yutaka Saito
The NICE classification is widely used around the world as a universal NBI endoscopic classification that is available without magnifying endoscopy. On the other hand, as histopathological criteria of curative endoscopic resection for early colorectal cancers is getting clear in Japan, endoscopists are required to diagnose their invasion depth accurately with magnifying endoscopy and obtain deeper histopathological materials by endoscopic mucosal resection (EMR)/endoscopic submucosal dissection (ESD). Therefore, we need a new classification which provides accurate qualitative and quantitative diagnosis linking to the appropriate treatment strategy including polypectomy, EMR/ESD, and surgery...
April 14, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29650932/-a-case-of-sigmoid-colon-cancer-with-locally-advanced-infiltration-curatively-resected-after-capeox-therapy
#10
Yuki Suematsu, Mao Nakayama, Shunsuke Yamagishi, Hiroyuki Saito, Miyuki Takahashi, Kyohei Kanematsu, Michiko Fukabori, Kazuhiko Wakabayashi, Yutaka Itoh
A 68-year-old man presented with malaise and abdominal swelling.Lower gastrointestinal endoscopy revealed a type 2 circumferential sigmoid colon cancer.Computed tomography suggested the cancer infiltrating bladder and abdominal wall with abscess.Because of locally advanced infiltration, the patient was treated with capecitabine plus oxaliplatin(CapeOX) plus bevacizumab therapy after loop-colostomy.After 2 courses of chemotherapy, a CT revealed tumor reduction and increased abscess, which was punctured drainage...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29643916/antireflux-metal-stent-for-initial-treatment-of-malignant-distal-biliary-obstruction
#11
Shinichi Morita, Yasuaki Arai, Shunsuke Sugawara, Miyuki Sone, Yasunari Sakamoto, Takuji Okusaka, Shigetaka Yoshinaga, Yutaka Saito, Shuji Terai
Objectives: To compare the use of an antireflux metal stent (ARMS) with that of a conventional covered self-expandable metal stent (c-CSEMS) for initial stenting of malignant distal biliary obstruction (MDBO). Materials and Methods: We retrospectively investigated 59 consecutive patients with unresectable MDBO undergoing initial endoscopic biliary drainage. ARMS was used in 32 patients and c-CSEMS in 27. Technical success, functional success, complications, causes of recurrent biliary obstruction (RBO), time to RBO (TRBO), and reintervention were compared between the groups...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29643697/vascular-healing-response-after-everolimus-eluting-stent-implantation-in-acute-coronary-syndrome-culprit-lesions-comparison-with-implantation-in-stable-angina-pectoris
#12
Yutaka Goryo, Teruyoshi Kume, Tomoya Ueda, Makoto Watanabe, Ryotaro Yamada, Yoji Neishi, Yoshihiko Saito, Shiro Uemura
Background: To evaluate the neointimal conditions of everolimus-eluting stents (EESs) implanted in culprit lesions of patients with acute coronary syndrome (ACS) compared with stable angina pectoris (SAP) using optical coherence tomography (OCT). EESs are second-generation drug-eluting stents that have recently been shown to be useful in patients with ACS as well as in patients with SAP. However, few studies have analyzed the intra-stent conditions of EESs that can lead to favorable results in such ACS lesions...
March 2018: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29619992/bullous-pemphigoid-accompanied-by-iga-nephropathy-and-atypical-haemolytic-uraemic-syndrome
#13
Kazumasa Oya, Rei Watanabe, Sae Inoue, Naoshi Obara, Yusuke Kiyoki, Mamiko Sakata-Yanagimoto, Shigeru Chiba, Chie Saito, Yutaka Matsumura, Yoshiyuki Nakamura, Yosuke Ishitsuka, Hiroshi Maruyama, Naoko Okiyama, Yasuhiro Fujisawa, Manabu Fujimoto
No abstract text is available yet for this article.
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29607945/atrial-fibrillation-had-less-impact-on-the-risk-of-ischemic-stroke-in-non-anticoagulated-patients-undergoing-hemodialysis-insight-from-the-rakuen-study
#14
Wataru Mitsuma, Taku Matsubara, Katsuharu Hatada, Shunsuke Imai, Makoto Tamura, Yutaka Tsubata, Kozo Ikarashi, Tetsuo Morioka, Noriko Saito, Hisaki Shimada, Shigeru Miyazaki
Objective The progress of non-anticoagulated patients with atrial fibrillation (AF) undergoing hemodialysis has not been determined. Using data from the RAKUEN (Registry of Atrial fibrillation in chronic Kidney disease Under hEmodialysis from Niigata) study, we examined the clinical characteristics and outcomes among hemodialysis patients with AF who were not receiving a vitamin K antagonist (VKA). Methods and Results Forty-three of 423 patients undergoing hemodialysis (-10%) were prescribed a VKA. The remaining 380 patients (age 64...
March 30, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29603399/validation-study-for-development-of-the-japan-nbi-expert-team-jnet-classification-of-colorectal-lesions
#15
Mineo Iwatate, Yasushi Sano, Shinji Tanaka, Shin-Ei Kudo, Shoichi Saito, Takahisa Matsuda, Yoshiki Wada, Takahiro Fujii, Hiroaki Ikematsu, Toshio Uraoka, Nozomu Kobayashi, Hisashi Nakamura, Kinichi Hotta, Takahiro Horimatsu, Naoto Sakamoto, Kuang-I Fu, Osamu Tsuruta, Hiroshi Kawano, Hiroshi Kashida, Yoji Takeuchi, Hirohisa Machida, Toshihiro Kusaka, Naohisa Yoshida, Ichiro Hirata, Takeshi Terai, Hiro-O Yamano, Takeshi Nakajima, Taku Sakamoto, Yuichiro Yamaguchi, Naoto Tamai, Naoko Nakano, Nana Hayashi, Shiro Oka, Hideki Ishikawa, Yoshitaka Murakami, Shigeaki Yoshida, Yutaka Saito
OBJECTIVE: The Japan NBI Expert Team (JNET) was organized to unify four previous magnifying NBI classifications (the Sano, Hiroshima, Showa, and Jikei classifications). The JNET working group created criteria (referred to as the NBI scale) for evaluation of vessel pattern (VP) and surface pattern (SP). We conducted a multicenter validation study of the NBI scale to develop the JNET classification of colorectal lesions. METHODS: Twenty-five expert JNET colonoscopists read 100 still NBI images with and without magnification on the web to evaluate the NBI findings and the necessity of the criteria for the final diagnosis...
March 30, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29601346/low-bone-mineral-density-in-elite-female-athletes-with-a-history-of-secondary-amenorrhea-in-their-teens
#16
Sayaka Nose-Ogura, Osamu Yoshino, Michiko Dohi, Mika Kigawa, Miyuki Harada, Takashi Kawahara, Yutaka Osuga, Shigeru Saito
OBJECTIVE: To determine whether secondary amenorrhea during teenage years influences bone mineral density (BMD) in female athletes in their 20s. DESIGN: Original research. SETTING: Japan Institute of Sports Sciences. PARTICIPANTS: Two hundred ten elite female athletes older than 20 years were included in the study. MAIN OUTCOME MEASURES: Information on the participants' past (ie, during their teenage years) and current menstrual cycle, training time, history of stress fractures, and blood tests for hormones received was obtained...
March 27, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29596567/malignant-disease-as-a-comorbidity-in-patients-with-severe-aortic-stenosis-clinical-presentation-outcomes-and-management
#17
Eri Minamino-Muta, Takao Kato, Takeshi Morimoto, Tomohiko Taniguchi, Kenji Nakatsuma, Yuki Kimura, Moriaki Inoko, Shinichi Shirai, Norio Kanamori, Koichiro Murata, Takeshi Kitai, Yuichi Kawase, Makoto Miyake, Chisato Izumi, Hirokazu Mitsuoka, Yutaka Hirano, Tomoki Sasa, Kazuya Nagao, Tsukasa Inada, Ryusuke Nishikawa, Yasuyo Takeuchi, Shintaro Yamagami, Keiichiro Yamane, Kanae Su, Akihiro Komasa, Katsuhisa Ishii, Yugo Yamashita, Yoshihiro Kato, Kensuke Takabayashi, Naritatsu Saito, Kenji Minatoya, Takeshi Kimura
Aim: To investigate the effect of malignancy on the outcomes of patients with severe aortic stenosis (AS) and the management strategy for AS with malignancy. Methods: Using data of 3815 patients with severe AS in a retrospective multicenter registry (CURRENT AS registry), we compared 3-year clinical outcomes among three groups based on malignancy status: with malignancy currently under treatment including best supportive care (malignancy group), with a history of malignancy without any current treatment (past history group), or without history of malignancy (no malignancy group)...
March 27, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29569309/patterns-of-reproductive-isolation-in-a-haplodiploid-strong-postmating-prezygotic-barriers-among-three-forms-of-a-social-spider-mite
#18
Yukie Sato, Hironori Sakamoto, Tetsuo Gotoh, Yutaka Saito, Jung-Tai Chao, Martijn Egas, Atsushi Mochizuki
In speciation research, much attention is paid to the evolution of reproductive barriers, preventing diverging groups from hybridizing back into one gene pool. The prevalent view is that reproductive barriers evolve gradually as a byproduct of genetic changes accumulated by natural selection and genetic drift in groups that are segregated spatially and/or temporally. Reproductive barriers, however, can also be reinforced by natural selection against maladaptive hybridization. These mutually compatible theories are both empirically supported by studies, analyzing relationships between intensity of reproductive isolation and genetic distance in sympatric taxa and allopatric taxa...
March 22, 2018: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29566399/endocuff-assisted-underwater-snare-polypectomy-in-complex-ascending-colon-neoplasia
#19
Taku Sakamoto, Seiichiro Abe, Marina Kaori Yoshida, Yusaku Tanaka, Yutaka Saito
No abstract text is available yet for this article.
March 22, 2018: Endoscopy
https://www.readbyqxmd.com/read/29553111/-sensitization-pattern-for-inhaled-and-food-allergens-in-japanese-recurrent-wheezers-under-60-months-of-age
#20
Mari Saito, Yutaka Kikuchi, Alan Kawarai Lefor, Wakamichi Shimamura
BACKGROUND: Allergen sensitization differs according to countries and regions. Understanding the characteristics of allergen sensitization in one's own country is useful for the treatment of patients with allergic diseases. Recently, Japanese cedar pollen (JCP) sensitization is increasing in young Japanese children. Therefore, we evaluated allergen sensitization patterns in under 60-month-old Japanese recurrent wheezers using multiple allergen tests. METHODS: Allergen tests for 204 Japanese recurrent wheezers between April 2010 and April 2016 were reviewed...
2018: Arerugī, [Allergy]
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