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L C Hewitt, I Z Inam, Y Saito, T Yoshikawa, A Quaas, A Hoelscher, E Bollschweiler, G E Fazzi, V Melotte, R E Langley, M Nankivell, D Cunningham, W Allum, G G Hutchins, H I Grabsch
BACKGROUND: Oesophageal (OeC) and gastric (GC) cancer patients are treated with similar multimodal therapy and have poor survival. There remains an urgent clinical need to identify biomarkers to individualise patient management and improve outcomes. Therapy with immune checkpoint inhibitors has shown promising results in other cancers. Proposed biomarkers to predict potential response to immune checkpoint inhibitors include DNA mismatch repair (MMR) and/or Epstein-Barr virus (EBV) status...
March 15, 2018: European Journal of Cancer
Suguru Mizuno, Yousuke Nakai, Hiroyuki Isayama, Tatsunori Suzuki, Kei Saito, Rie Uchino, Naminatsu Takahara, Hirofumi Kogure, Minoru Tada, Kazuhiko Koike
No abstract text is available yet for this article.
March 12, 2018: Endoscopic Ultrasound
Y Satoh, K Nakano, H Yoshinari, S Nakayamada, S Iwata, S Kubo, I Miyagawa, M Yoshikawa, Y Miyazaki, K Saito, Y Tanaka
It has been reported that T helper 17 cells are involved in the pathogenesis of systemic lupus erythematosus, but there is no report on interleukin-17-targeted therapy. We report a case of a 62-year-old female who presented with psoriasis vulgaris and refractory lupus nephritis. Because her conditions were resistant to conventional treatment, and flow cytometry confirmed the proliferation of activated T helper 17 cells in peripheral blood, and examination of a renal biopsy tissue sample confirmed infiltration of numerous interleukin-17-positive lymphocytes to the renal interstitium, administration of the anti-interleukin-17A antibody secukinumab was initiated...
January 1, 2018: Lupus
Seiji Niho, Norihiko Ikeda, Hiroshi Michimae, Kenji Suzuki, Hiroshi Sakai, Takayuki Kaburagi, Katsuo Yoshiya, Koichi Minato, Terufumi Kato, Hiroaki Okamoto, Takashi Seto, Yukio Hosomi, Kimihiro Shimizu, Haruhiro Saito, Masanori Tsuchida, Hideo Kunitoh, Masahiro Tsuboi, Masahiro Takeuchi, Koshiro Watanabe
OBJECTIVES: The TORG0809 study was a multicenter feasibility study of long-term single-agent therapy with S-1 after docetaxel plus cisplatin therapy in patients with completely resected stage II or stage IIIA non-small cell lung cancer. We report the results of the final overall survival (OS) analysis. PATIENTS AND METHODS: A total of 129 eligible patients received 3 cycles of docetaxel (60 mg/m, day 1) plus cisplatin (80 mg/m, day 1), followed by S-1 at 40 mg/m twice daily for 14 consecutive days, for >6 months (maximum, 1 y)...
March 7, 2018: American Journal of Clinical Oncology
Daisuke Kawahara, Hisashi Nakano, Shuichi Ozawa, Akito Saito, Tomoki Kimura, Tatsuhiko Suzuki, Masato Tsuneda, Sodai Tanaka, Yoshimi Ohno, Yuji Murakami, Yasushi Nagata
OBJECTIVES: We examine the contrast agent Lipiodol effect on the relative biological effectiveness (RBE) values for flattening filter free (FFF) and flattening filter (FF) beams of 6 MV-Xray (6 MVX) and 10 MVX. METHODS: Lipiodol was placed at 5 cm depth in water. According to the microdosimetric kinetic model, the RBE values for killing the human liver hepatocellular cells were calculated from dose and lineal energy (yd(y)) from Monte Carlo simulations. RBE200kVX and RBECo were defined as the ratios of dose using reference radiation (200 kVX, Co-ɤ) to the dose of test radiation (FFF and FF beams for 6 MV and 10 MV) to produce the same biological effects...
February 2018: Physica Medica: PM
K Tabeta, M Hosojima, M Nakajima, S Miyauchi, H Miyazawa, N Takahashi, Y Matsuda, N Sugita, Y Komatsu, K Sato, T Ishikawa, K Akiishi, K Yamazaki, K Kato, A Saito, H Yoshie
BACKGROUND AND OBJECTIVES: Previous reports suggest that several serum biomarkers play roles in the pathogenesis, inflammatory response, and oxidative stress in periodontitis caused by bacterial infections, linking chronic periodontitis to atherosclerotic vascular disease (ASVD). The aim of this preliminary study was to investigate, in a Japanese cross-sectional community survey, potential serum biomarkers of periodontitis that are associated with ASVD and chronic periodontitis. MATERIAL AND METHODS: The study cohort included a total of 108 male subjects who underwent annual health examinations...
March 8, 2018: Journal of Periodontal Research
Denis R Beckford Vera, Christof C Smith, Lisa M Bixby, Dylan M Glatt, Stuart S Dunn, Ryoichi Saito, William Y Kim, Jonathan S Serody, Benjamin G Vincent, Matthew C Parrott
The ability to non-invasively monitor tumor-infiltrating T cells in vivo could provide a powerful tool to visualize and quantify tumor immune infiltrates. For non-invasive evaluations in vivo, an anti-CD3 mAb was modified with desferrioxamine (DFO) and radiolabeled with zirconium-89 (Zr-89 or 89Zr). Radiolabeled 89Zr-DFO-anti-CD3 was tested for T cell detection using positron emission tomography (PET) in both healthy mice and mice bearing syngeneic bladder cancer BBN975. In vivo PET/CT and ex vivo biodistribution demonstrated preferential accumulation and visualization of tracer in the spleen, thymus, lymph nodes, and bone marrow...
2018: PloS One
N Takemae, P T Nguyen, V T Le, T N Nguyen, T L To, T D Nguyen, V P Pham, H V Vo, Q V T Le, H T Do, D T Nguyen, Y Uchida, T Saito
Three subtypes-H1N1, H1N2 and H3N2-of influenza A viruses of swine (IAVs-S) are currently endemic in swine worldwide, but there is considerable genotypic diversity among each subtype and limited geographical distribution. Through IAVs-S monitoring in Vietnam, two H1N2 influenza A viruses were isolated from healthy pigs in Ba Ria-Vung Tau Province, Southern Vietnam, on 2 December 2016. BLAST and phylogenetic analyses revealed that their HA and NA genes were derived from those of European avian-like H1N2 IAVs-S that contained avian-origin H1 and human-like N2 genes, and were particularly closely related to those of IAVs-S circulating in the Netherlands, Germany or Denmark...
March 6, 2018: Transboundary and Emerging Diseases
S Takács, F Ditrói, Z Szűcs, M Aikawa, H Haba, Y Komori, M Saito
Cross sections of alpha particle induced nuclear reactions on iridium were investigated using a 51.2-MeV alpha particle beam. The standard stacked-foil target technique and the activation method were applied. The activity of the reaction products was assessed without chemical separation using high resolution gamma-ray spectrometry. Excitation functions for production of gold, platinum and iridium isotopes (196m2 Au,196m,g Au,195m,g Au,194 Au,193 m,g Au,192 Au,191m,g Au,191 Pt,195m Pt,194g Ir,194m Ir,192g Ir,190g Ir and189 Ir) were determined and compared with available earlier measured experimental data and results of theoretical calculations using TALYS code system...
February 22, 2018: Applied Radiation and Isotopes
K Nakamura, K Saito, J Kashiwazaki, T Aoyagi, K Arai, Y Hara, S Kobari, H Mori, K Ohashi, Y Takano, M Kaku, K Kanemitsu
We evaluated the bacterial removal effects of hand washing with ozonated water using the ASTM E1174 standard test method. Thirty healthy volunteers were assigned randomly to three groups: ozonated water, antimicrobial soap and water, and non-antimicrobial soap and water. A 3 log 10 CFU reduction was achieved by washing hands with ozonated water or antimicrobial soap and water. However, ozonated water was not significantly superior to non-antimicrobial soap and water. Ozonated water may remove bacteria from the hands to at least a similar extent as that by non-antimicrobial soap and water in the absence of visible dirt or body fluid contamination...
February 13, 2018: Journal of Hospital Infection
N Miyoshi, T Tanigawa, S Nishioka, K Maruyama, E Eguchi, K Tanaka, I Saito, K Yamazaki, Y Miyake
BACKGROUND AND OBJECTIVE: Salivary lactate dehydrogenase (LDH) was reported to be a useful parameter for the screening of periodontal disease. We performed a cross-sectional study to verify the usefulness of salivary LDH as a biomarker of periodontitis and to investigate the association of severity of periodontitis with systemic inflammation by measuring salivary LDH and serum high sensitive C-reactive protein (hs-CRP) levels in a community-based middle-aged and elderly population in Japan...
February 15, 2018: Journal of Periodontal Research
M Isawa, R Tashiro, C Naruse, Y Yamaguchi, H Itoh, T Nishimura, M Tomi, H Shimada, H Saito, M Mochizuki, E Nakashima
Patients benefit from drug therapy not only through pharmacological mechanisms, but also through non-pharmacological action (placebo effect), which may be mediated in part by the prefrontal area of the brain. We consider that the difference between responders and non-responders to placebo might be related to polymorphisms in the serotonin transporter-linked polymorphic region (5-HTTLPR). To study this idea, we performed a randomized double-blind clinical trial using caffeine and lactose (placebo). Activity in the prefrontal area of the brain was measured in terms of blood flow by means of near-infrared spectroscopy (NIRS) as an objective indicator...
January 2, 2018: Die Pharmazie
T Nishida, T Hayashi, T Inamoto, R Kato, N Ibuki, K Takahara, T Takai, Y Yoshikawa, T Uchimoto, K Saito, N Tanda, J Kouno, K Minami, H Uehara, H Hirano, H Nomi, Y Okada, H Azuma
BACKGROUND: Hydrogen (H2) and carbon monoxide (CO) gas are both reported to reduce reactive oxygen species and alleviate tissue ischemia-reperfusion (I-R) injury. The present study was conducted to evaluate the effects of a mixture of H2 gas and CO gas (dual gas) in comparison with hydrogen gas (H2: 2%) alone on I-R renal injury (composition of dual gas; N2: 77.8%; O2: 20.9%; H2: 1.30%; CO: 250 parts per million). METHODS: Adult male Sprague-Dawley rats (body weight 250-280 g) were divided into 5 groups: (1) sham operation control, (2) dual gas inhalation (dual treatment) without I-R treatment, (3) I-R renal injury, (4) H2 gas alone inhalation (H2 treatment) with I-R renal injury, and (5) dual treatment with I-R renal injury...
January 2018: Transplantation Proceedings
T Kodaira, Y Kagami, T Shibata, N Shikama, Y Nishimura, S Ishikura, K Nakamura, Y Saito, Y Matsumoto, T Teshima, Y Ito, T Akimoto, K Nakata, T Toshiyasu, K Nakagawa, Y Nagata, T Nishimura, T Uno, M Kataoka, A Yorozu, M Hiraoka
Background: We assessed the non-inferiority of accelerated fractionation (AF) (2.4 Gy/fraction) compared with standard fractionation (SF) (2 Gy/fraction) regarding progression-free survival (PFS) in patients with T1-2N0M0 glottic cancer (GC). Patients and Methods: In this multi-institutional, randomized, phase 3 trial, patients were enrolled from 32 Japanese institutions. Key inclusion criteria were GC T1 - 2N0M0, age 20 - 80, Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 1, and adequate organ function...
February 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
M Amenomori, X J Bi, D Chen, T L Chen, W Y Chen, S W Cui, Danzengluobu, L K Ding, C F Feng, Zhaoyang Feng, Z Y Feng, Q B Gou, Y Q Guo, H H He, Z T He, K Hibino, N Hotta, Haibing Hu, H B Hu, J Huang, H Y Jia, L Jiang, F Kajino, K Kasahara, Y Katayose, C Kato, K Kawata, M Kozai, Labaciren, G M Le, A F Li, H J Li, W J Li, C Liu, J S Liu, M Y Liu, H Lu, X R Meng, T Miyazaki, K Mizutani, K Munakata, T Nakajima, Y Nakamura, H Nanjo, M Nishizawa, T Niwa, M Ohnishi, I Ohta, S Ozawa, X L Qian, X B Qu, T Saito, T Y Saito, M Sakata, T K Sako, J Shao, M Shibata, A Shiomi, T Shirai, H Sugimoto, M Takita, Y H Tan, N Tateyama, S Torii, H Tsuchiya, S Udo, H Wang, H R Wu, L Xue, Y Yamamoto, K Yamauchi, Z Yang, A F Yuan, T Yuda, L M Zhai, H M Zhang, J L Zhang, X Y Zhang, Y Zhang, Yi Zhang, Ying Zhang, Zhaxisangzhu, X X Zhou
We analyze the Sun's shadow observed with the Tibet-III air shower array and find that the shadow's center deviates northward (southward) from the optical solar disk center in the "away" ("toward") interplanetary magnetic field (IMF) sector. By comparing with numerical simulations based on the solar magnetic field model, we find that the average IMF strength in the away (toward) sector is 1.54±0.21_{stat}±0.20_{syst} (1.62±0.15_{stat}±0.22_{syst}) times larger than the model prediction. These demonstrate that the observed Sun's shadow is a useful tool for the quantitative evaluation of the average solar magnetic field...
January 19, 2018: Physical Review Letters
K Ogata, S Jeon, D-S Ko, I S Jung, J H Kim, K Ito, Y Kubo, K Takei, S Saito, Y-H Cho, H Park, J Jang, H-G Kim, J-H Kim, Y S Kim, W Choi, M Koh, K Uosaki, S G Doo, Y Hwang, S Han
Nano-structured silicon is an attractive alternative anode material to conventional graphite in lithium-ion batteries. However, the anode designs with higher silicon concentrations remain to be commercialized despite recent remarkable progress. One of the most critical issues is the fundamental understanding of the lithium-silicon Coulombic efficiency. Particularly, this is the key to resolve subtle yet accumulatively significant alterations of Coulombic efficiency by various paths of lithium-silicon processes over cycles...
February 2, 2018: Nature Communications
Y Matsumoto, Y Asao, A Yoshikawa, H Sekiguchi, M Takada, M Furu, S Saito, M Kataoka, H Abe, T Yagi, K Togashi, M Toi
We analysed the vascular morphology of the palm using a photoacoustic tomography (PAT) instrument with a hemispherical detector array. The three-dimensional (3D) morphology of blood vessels was determined noninvasively. Overall, 12 females and 11 males were recruited as healthy volunteers. Their ages were distributed almost evenly from 22 to 59 years. In all cases, many vascular networks were observed just beneath the skin and were determined to be veins anatomically. To analyse the major arteries, the layer containing the subcutaneous venous network was removed from the image...
January 15, 2018: Scientific Reports
T Numata, T Nagatani, K Shirai, T Maeda, K Mae, M Nakasu, M Saito, T Usuda, R Tsuboi, Y Okubo
A 70-year-old man presented to our clinic with a 10-year history of recurrent pruritic erythema and plaques on his trunk and limbs. Based on the pathological findings and monoclonal rearrangement of the T-cell receptor (TCR)-Cβ1 gene, mycosis fungoides (T2N0M0B0 stage IB) was diagnosed. Despite combination therapy including histone deacetylase inhibitor (vorinostat), the symptoms slowly evolved into Sézary syndrome (SS; T4N1M0B2) over 4 years, with dense infiltrates due to atypical lymphocytes expressing CCR4 developing in the entire dermis...
April 2018: Clinical and Experimental Dermatology
Toshiaki Yoshimoto, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Y U Saito, Chie Takasu, Daichi Ishikawa, Hiroki Teraoku, Yoshimi Bando, Mitsuo Shimada
BACKGROUND/AIM: We report the outcomes of sorafenib therapy for advanced hepatocellular carcinoma (HCC) in our Department. PATIENTS AND METHODS: Thirty-eight patients with unresectable HCC who were administrated sorafenib from 2009 to 2015 were investigated retrospectively. RESULTS: The 1-year overall survival rate was 59.3%. The macroscopic vascular invasion and response rate were independent prognostic factors of survival. Surgical resection after sorafenib achieved long-term survival in two cases...
January 2018: Anticancer Research
Y A Saito, M Camilleri
No abstract text is available yet for this article.
January 2018: Alimentary Pharmacology & Therapeutics
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