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https://www.readbyqxmd.com/read/28911357/pulmonary-tuberculosis-diagnostic-practices-among-people-living-with-the-human-immunodeficiency-virus-in-lesotho
#1
D E O'Connor, K Frederix, S Saito, L B Maama, Y Hirsch-Moverman, B Pitt, E Hayes-Larson, L Lebelo, M Shale, A A Howard
SETTING: Twelve health facilities in Berea District, Lesotho, that participated in the Start TB Patients on ART and Retain on Treatment (START) Study, a mixed-methods cluster-randomized trial evaluating a combination intervention package to improve early initiation of antiretroviral therapy (ART) and anti-tuberculosis treatment success among patients with tuberculosis (TB) and human immunodeficiency virus (HIV). OBJECTIVE: To assess TB and HIV diagnostic practices among TB-HIV patients...
October 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28911027/green-nail-syndrome
#2
H Matsuura, A Senoo, M Saito, Y Hamanaka
No abstract text is available yet for this article.
September 1, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28910620/ctag-paperclip-reveals-alternative-polyadenylation-promotes-cell-type-specific-protein-diversity-and-shifts-araf-isoforms-with-microglia-activation
#3
Hun-Way Hwang, Yuhki Saito, Christopher Y Park, Nathalie E Blachère, Yoko Tajima, John J Fak, Ilana Zucker-Scharff, Robert B Darnell
Alternative polyadenylation (APA) is increasingly recognized to regulate gene expression across different cell types, but obtaining APA maps from individual cell types typically requires prior purification, a stressful procedure that can itself alter cellular states. Here, we describe a new platform, cTag-PAPERCLIP, that generates APA profiles from single cell populations in intact tissues; cTag-PAPERCLIP requires no tissue dissociation and preserves transcripts in native states. Applying cTag-PAPERCLIP to profile four major cell types in the mouse brain revealed common APA preferences between excitatory and inhibitory neurons distinct from astrocytes and microglia, regulated in part by neuron-specific RNA-binding proteins NOVA2 and PTBP2...
September 13, 2017: Neuron
https://www.readbyqxmd.com/read/28905472/design-paper-japan-endoscopy-database-jed-a-prospective-big-database-project-related-to-gastroenterological-endoscopy-in-japan
#4
K Matsuda, K Tanaka, M Fujishiro, Y Saito, K Ohtsuka, I Oda, C Katada, M Kato, M Kida, K Kobayashi, S Hoteya, T Horimatsu, S Kodashima, T Matsuda, M Muto, H Yamamoto, S Ryozawa, R Iwakiri, H Kutsumi, H Miyata, M Kato, K Haruma, K Fujimoto, N Uemura, M Kaminishi, H Tajiri
The advent of electrical medical records brought image filing systems to many hospitals, as well as electrical endoscopic medical records. However, data integration among multiple different venders has not yet been accomplished. We start the Japan Endoscopic Database (JED) Project endorsed by Japan Gastroenterological Endoscopy Society (JGES) from January 2015. The purposes of this project are as follows: 1) developing the world's largest endoscopic database generated from daily use of the reporting system 2) capturing the actual performance of endoscopic practice in Japan; and 3) standardizing the terminology and fundamental items for the registry of clinical studies...
September 14, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28887197/reduction-in-open-field-activity-in-the-absence-of-memory-deficits-in-the-app-nl-g-f-knock-in-mouse-model-of-alzheimer-s-disease
#5
Lauren S Whyte, Kim M Hemsley, Adeline A Lau, Sofia Hassiotis, Takashi Saito, Takaomi C Saido, John J Hopwood, Timothy J Sargeant
The recent development of knock-in mouse models of Alzheimer's disease provides distinct advantages over traditional transgenic mouse models that rely on over-expression of amyloid precursor protein. Two such knock-in models that have recently been widely adopted by Alzheimer's researchers are the App(NL-F) and App(NL-G-F) mice. This study aimed to further characterise the behavioural phenotype and amyloid plaque distribution of App(NL-G-F/NL-G-F) (C57BL/6J background) mice at six-months of age. An attempt to replicate a previous study that observed deficits in working memory in the Y-maze, showed no difference between App(NL-G-F/NL-G-F) and wild-type mice...
September 5, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28885724/first-progress-report-on-the-japan-endoscopy-database-jed-project
#6
S Kodashima, K Tanaka, K Matsuda, M Fujishiro, Y Saito, K Ohtsuka, I Oda, C Katada, M Kato, M Kida, K Kobayashi, S Hoteya, T Horimatsu, T Matsuda, M Muto, H Yamamoto, S Ryozawa, R Iwakiri, H Kutsumi, H Miyata, M Kato, K Haruma, K Fujimoto, N Uemura, M Kaminishi, H Tajiri
OBJECTIVES: The Japan Endoscopy Database (JED) Project was initiated to develop the world's largest endoscopic database, capture the actual performance of endoscopic practice, and standardize the terminology and fundamental items needed for a clinical and research registry. This paper presents a progress report on the first phase of this project undertaken at 8 endoscopic centers in Japan. METHODS: The list of data items to be collected was drafted by the MSED-J (Minimal Standard Endoscopic Database) subcommittee...
September 8, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28864106/gastric-mesenchymal-tumors-as-incidental-findings-during-roux-en-y-gastric-bypass
#7
Everton Cazzo, Helena Paes de Almeida de Saito, José Carlos Pareja, Elinton Adami Chaim, Francisco Callejas-Neto, João de Souza Coelho-Neto
BACKGROUND: Occurrences of mesenchymal tumors have been more recognized in recent years, and the incidental diagnosis of these lesions during bariatric surgery has been previously reported. OBJECTIVE: To describe the cases of incidentally diagnosed mesenchymal tumors during consecutive bariatric surgeries. SETTING: Private health-providing service, Brazil. METHODS: A retrospective population-based study, which enrolled individuals who consecutively underwent Roux-en-Y gastric bypass at a single center from January 2006 through July 2016...
July 29, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28836776/mechanistic-insight-into-reversible-core-structural-changes-of-dinuclear-%C3%AE-hydroxoruthenium-ii-complexes-with-a-2-8-di-2-pyridyl-1-9-10-anthyridine-backbone-prior-to-water-oxidation-catalysis
#8
Masanari Hirahara, Sho Nagai, Kosuke Takahashi, Shunsuke Watabe, Taisei Sato, Kenji Saito, Tatsuto Yui, Yasushi Umemura, Masayuki Yagi
proximal,proximal-(p,p)-[Ru(II)2(tpy)2LXY](n+) (tpy = 2,2';6',2″-terpyridine, L = 5-phenyl-2,8-di-2-pyridyl-1,9,10-anthyridine, and X and Y = other coordination sites) yields the structurally and functionally unusual Ru(II)(μ-OH)Ru(II) core, which is capable of catalyzing water oxidation with key water insertion to the core (Inorg. Chem. 2015, 54, 7627). Herein, we studied a sequence of bridging-ligand substitution among p,p-[Ru2(tpy)2L(μ-Cl)](3+) (Ru2(μ-Cl)), p,p-[Ru2(tpy)2L(μ-OH)](3+) (Ru2(μ-OH)), p,p-[Ru2(tpy)2L(OH)(OH2)](3+) (Ru2(OH)(OH2)), and p,p-[Ru2(tpy)2L(OH)2](2+) (Ru2(OH)2) in aqueous solution...
August 24, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28830195/is-liver-perfusion-ct-reproducible-a-study-on-intra-and-inter-observer-agreement-of-normal-hepatic-hemodynamic-parameters-obtained-with-two-different-software-packages
#9
Elisa Almeida Sathler Bretas, Ulysses S Torres, Lucas Torres, Daniel Bekhor, Celso Fernando Saito Filho, Douglas Jorge Racy, Lorenzo Faggioni, Giuseppe D'Ippolito
OBJECTIVES: To evaluate the agreement between the measurements of perfusion CT parameters in normal livers by using two different software packages. METHODS: This retrospective study was based on 78 liver perfusion CT examinations acquired for detecting suspected liver metastasis. Patients with any morphological or functional hepatic abnormalities were excluded. The final analysis included 37 patients (59.7 ± 14.9 y). Two readers (1 and 2) independently measured perfusion parameters using different software packages from two major manufacturers (A and B)...
August 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28818825/mr-imaging-features-of-the-cerebellum-in-adult-onset-neuronal-intranuclear-inclusion-disease-8-cases
#10
A Sugiyama, N Sato, Y Kimura, T Maekawa, M Enokizono, Y Saito, Y Takahashi, H Matsuda, S Kuwabara
Neuronal intranuclear inclusion disease is a neurodegenerative disorder pathologically characterized by eosinophilic hyaline intranuclear inclusions. A high-intensity signal along the corticomedullary junction on DWI has been described as a specific MR imaging finding of the cerebrum in neuronal intranuclear inclusion disease. However, MR imaging findings of the cerebellum in neuronal intranuclear inclusion disease have not been fully evaluated. Here, we review MR imaging findings of the cerebellum in a series of 8 patients with pathologically confirmed neuronal intranuclear inclusion disease...
August 17, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28817942/-the-current-status-of-diagnostic-tools-for-leptospirosis
#11
Mitsumasa Saito, Yasuhiko Nikaido, Masahiro Matsumoto, Midori Ogawa, Sharon Y A M Villanueva
Leptospirosis is a worldwide zoonosis caused by pathogenic Leptospira spp. The severity of leptospirosis vary from mild, flu-like disease to a more severe form, Weil's disease causing jaundice, hemorrhage, renal failure, and even death. Every year, 300,000‒500,000 cases of severe leptospirosis are reported around the world, with the case fatality rate being 10‒30%. The usual diagnostic tools for leptospirosis are 1) direct observation of leptospires in blood and urine under dark-field microscope, 2) isolation of leptospires from blood, cerebrospinal fluid (CSF), or urine samples by culture, 3) microscopic agglutination test (MAT) to detect anti-Leptospira antibodies in serum, and 4) PCR to detect Leptospira DNA...
August 15, 2017: JARMAM: Journal of the Association for Rapid Method and Automation in Microbiology
https://www.readbyqxmd.com/read/28816304/iodoarene-catalyzed-oxidative-transformations-using-molecular-oxygen
#12
K Miyamoto, J Yamashita, S Narita, Y Sakai, K Hirano, T Saito, C Wang, M Ochiai, M Uchiyama
Molecular oxygen serves as a useful oxidant for the glycol scission of 1,2-diols and the Hofmann rearrangement of primary amides using pentamethyliodobenzene as a catalyst. The use of isobutyraldehyde and Lewis basic nitriles under O2 enabled the iodine(i)/(iii) catalytic cycle, where in situ-generated peracid acts as a terminal oxidant.
August 29, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28807087/allergic-bronchopulmonary-mycosis-due-to-exposure-to-eurotium-herbariorum-after-the-great-east-japan-earthquake
#13
Chiyako Oshikata, Maiko Watanabe, Akemi Saito, Masatsugu Ishida, Seiichi Kobayashi, Rumi Konuma, Yoichi Kamata, Jun Terajima, Junichi Cho, Masaru Yanai, Naomi Tsurikisawa
BACKGROUND: Indoor mold levels typically increase after natural disasters, flooding, and water damage. Eurotium herbariorum is the sexual stage of Aspergillus glaucus. Case Presentation A 66-year-old, Japanese male, ex-smoker had been diagnosed with bronchial asthma when he was five years old; he achieved remission at the age of 13 years. He was displaced from his home during the Great East Japan Earthquake on March 11, 2011 and moved to temporary housing in Miyagi Prefecture in June 2011...
August 15, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28794945/third-order-nonlinear-optical-properties-of-one-dimensional-quinoidal-oligothiophene-derivatives-involving-phenoxyl-groups
#14
Ryohei Kishi, Tsubasa Katsurayama, Shoki Ochi, Akihiro Makino, Naoyuki Matsushita, Michika Saito, Takanori Nagami, Jun-Ya Fujiyoshi, Masayoshi Nakano
The diradical characters (y) and third-order nonlinear optical (NLO) properties of open-shell quinoidal oligothiophene derivatives with phenoxyl groups, and the corresponding reduced (hydrogenated)-state oligomers, are investigated by using the broken-symmetry density functional theory method. The oxidized (dehydrogenated) states are predicted to have an open-shell singlet ground state and their y values increase with the number of units. Static second hyperpolarizabilities (γ) of the open-shell oligomers with intermediate y are shown to be enhanced significantly compared with those of the closed-shell analogues...
August 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28761576/efficacy-and-safety-of-the-dipeptidyl-peptidase-4-inhibitor-sitagliptin-on-atherosclerosis-%C3%AE-cell-function-and-glycemic-control-in-japanese-patients-with-type-2-diabetes-mellitus-who-are-treatment-na%C3%A3-ve-or-poorly-responsive-to-antidiabetes-agents-a-multicenter
#15
Yuya Tsurutani, Masao Omura, Yoko Matsuzawa, Jun Saito, Mariko Higa, Matsuo Taniyama, Tetsuo Nishikawa
BACKGROUND: Sitagliptin, a dipeptidyl peptidase-4 inhibitor, is widely used in patients with type 2 diabetes. However, the pleiotropic effects of sitagliptin is not well understood. OBJECTIVE: To assess the clinical efficacy and safety of sitagliptin on atherosclerosis, β-cell function, and glycemic control in Japanese patients with type 2 diabetes. METHODS: A prospective observational study of 270 patients with type 2 diabetes mellitus was carried out...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28745320/surfactant-protein-d-inhibits-activation-of-non-small-cell-lung-cancer-associated-mutant-egfr-and-affects-clinical-outcomes-of-patients
#16
Y Umeda, Y Hasegawa, M Otsuka, S Ariki, R Takamiya, A Saito, Y Uehara, H Saijo, K Kuronuma, H Chiba, H Ohnishi, Y Sakuma, H Takahashi, Y Kuroki, M Takahashi
Tyrosine kinase inhibitor (TKI)-sensitive and TKI-resistant mutations of epidermal growth factor receptor (EGFR) are associated with lung adenocarcinoma. EGFR mutants were previously shown to exhibit ligand-independent activation. We have previously demonstrated that pulmonary surfactant protein D (SP-D, SFTPD) suppressed wild-type EGFR signaling by blocking ligand binding to EGFR. We herein demonstrate that SFTPD downregulates ligand-independent signaling in cells harboring EGFR mutations such as TKI-sensitive exon 19 deletion (Ex19del) and L858R mutation as well as TKI-resistant T790M mutation, subsequently suppressing cellular growth and motility...
July 24, 2017: Oncogene
https://www.readbyqxmd.com/read/28730823/pathophysiological-analysis-of-the-progression-of-hepatic-lesions-in-stam-mice
#17
T Saito, M Muramatsu, Y Ishii, Y Saigo, T Konuma, Y Toriniwa, K Miyajima, T Ohta
Nonalcoholic steatohepatitis (NASH) is a current health issue since the disease often leads to hepatocellular carcinoma; however, the pathogenesis of the disease has still not been fully elucidated. In this study, we investigated the pathophysiological changes observed in hepatic lesions in STAM mice, a novel NASH model. STAM mice, high fat-diet (HFD) fed mice, and streptozotocin (STZ) treated mice were prepared, and changes over time, such as biological parameters, mRNA expression, and histopathological findings, were evaluated once animal reached 5, 7, and 10 weeks of age...
July 18, 2017: Physiological Research
https://www.readbyqxmd.com/read/28722315/association-between-chronic-musculoskeletal-pain-and-executive-function-in-community-dwelling-older-adults
#18
S Murata, R Sawa, N Nakatsu, T Saito, T Sugimoto, R Nakamura, S Misu, Y Ueda, R Ono
BACKGROUND: We examined the association of chronic musculoskeletal pain with executive function in community-dwelling older adults. METHOD: This cross-sectional study recruited 234 community-dwelling older adults in Japan (mean age: 72.7, women: 62.8%). Chronic musculoskeletal pain was defined as having moderate or more severe pain lasting ≥ 3 months. Executive function was assessed using the Digit Symbol Substitution Test (DSST), Trail Making Test (TMT) parts A and B, Letter Verbal Fluency Test (LVFT) and Category Verbal Fluency Test (CVFT)...
July 18, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28718531/next-generation-sequencing-for-patients-with-non-obstructive-azoospermia-implications-for-significant-roles-of-monogenic-oligogenic-mutations
#19
S Nakamura, M Miyado, K Saito, M Katsumi, A Nakamura, Y Kobori, Y Tanaka, H Ishikawa, A Yoshida, H Okada, K Hata, K Nakabayashi, K Okamura, H Ogata, Y Matsubara, T Ogata, H Nakai, M Fukami
Azoospermia affects up to 1% of adult men. Non-obstructive azoospermia is a multifactorial disorder whose molecular basis remains largely unknown. To date, mutations in several genes and multiple submicroscopic copy-number variations (CNVs) have been identified in patients with non-obstructive azoospermia. The aim of this study was to clarify the contribution of nucleotide substitutions in known causative genes and submicroscopic CNVs in the genome to the development of non-obstructive azoospermia. To this end, we conducted sequence analysis of 25 known disease-associated genes using next-generation sequencing and genome-wide copy-number analysis using array-based comparative genomic hybridization...
July 2017: Andrology
https://www.readbyqxmd.com/read/28713250/impaired-in-vivo-gamma-oscillations-in-the-medial-entorhinal-cortex-of-knock-in-alzheimer-model
#20
Tomoaki Nakazono, Travis N Lam, Ayushi Y Patel, Masashi Kitazawa, Takashi Saito, Takaomi C Saido, Kei M Igarashi
The entorhinal cortex (EC) has bidirectional connections with the hippocampus and plays a critical role in memory formation and retrieval. EC is one of the most vulnerable regions in the brain in early stages of Alzheimer's disease (AD), a neurodegenerative disease with progressive memory impairments. Accumulating evidence from healthy behaving animals indicates gamma oscillations (30-100 Hz) as critical for mediating interactions in the circuit between EC and hippocampus. However, it is still unclear whether gamma oscillations have causal relationship with memory impairment in AD...
2017: Frontiers in Systems Neuroscience
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