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https://www.readbyqxmd.com/read/28213546/environmental-surveillance-of-norovirus-genogroups-i-and-ii-for-sensitive-detection-of-epidemic-variants
#1
Shinobu Kazama, Takayuki Miura, Yoshifumi Masago, Yoshimitsu Konta, Kentaro Tohma, Takafumi Manaka, Xiaofang Liu, Daisuke Nakayama, Takashi Tanno, Mayuko Saito, Hitoshi Oshitani, Tatsuo Omura
Sewage samples have been investigated to study the level of noroviruses concentration in sewage or the genotypes of noroviruses circulating in human populations. However, the statistical relationship between the concentration of the virus and the number of infected individuals, and the clinical importance of genotypes or strains detected in sewage are unclear. In this study, we carried out both environmental and clinical surveillance of noroviruses for three years: 2013-2016. We performed cross-correlation analysis between the concentrations of norovirus GI or GII in sewage samples collected weekly and the number of gastroenteritis cases...
February 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28212665/clinical-outcome-of-periodontal-regenerative-therapy-using-collagen-membrane-and-deproteinized-bovine-bone-mineral-a-2-5-year-follow-up-study
#2
Daisuke Irokawa, Takahiro Takeuchi, Katsuya Noda, Hiroaki Goto, Masahiro Egawa, Sachiyo Tomita, Hiroki Sugito, Masahiko Nikaido, Atsushi Saito
BACKGROUND: This study aimed to evaluate, longitudinally, the outcome of periodontal regenerative therapy using a deproteinized bovine bone mineral (DBBM) in combination with a collagen barrier (CB) for the treatment of intrabony defects. RESULTS: Patients with chronic periodontitis who have completed initial periodontal therapy participated in this study. They had at least one 2- or 3-wall intrabony periodontal defect of ≥3 mm in depth. During surgery, defects were filled with DBBM and covered with CB...
February 17, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28209790/unexpected-functional-consequences-of-the-loss-of-the-autophagy-related-conjugation-system
#3
Toshiro Saito, Junichi Sadoshima
We discuss the recent finding by Mizishima's group regarding the role of the autophagy-related conjugation system in mediating the closure of autophagosomes and its implication in the study of autophagy in mammalian cells. The study not only shows a novel function of the autophagy-related conjugation system but also indicates that mammalian cells are capable of generating autophagosomes even without it.
February 17, 2017: Circulation Research
https://www.readbyqxmd.com/read/28208812/relationship-between-self-reported-dietary-nutrient-intake-and-self-reported-sleep-duration-among-japanese-adults
#4
Yoko Komada, Hajime Narisawa, Fumitaka Ueda, Hitomi Saito, Hiroyuki Sakaguchi, Makoto Mitarai, Rina Suzuki, Norihisa Tamura, Shigeru Inoue, Yuichi Inoue
Several studies have reported that short sleep duration is a risk factor for obesity and metabolic disease. Moreover, both sleep duration and sleep timing might independently be associated with dietary nutrient intake. In this study, we investigated the associations between self-reported sleep duration and dietary nutrient intake, with and without adjustments for variations in sleep timing (i.e., the midpoint of sleep). We conducted a questionnaire survey, comprising a validated brief self-administered diet history questionnaire (BDHQ) and the Japanese version of the Pittsburgh Sleep Quality Index (PSQI) among 1902 healthy Japanese adults and found that the dietary intakes of several nutrients correlated with sleep duration among men regardless of adjustment for the midpoint of sleep...
February 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28208699/induction-of-syndecan-4-by-organic-inorganic-hybrid-molecules-with-a-1-10-phenanthroline-structure-in-cultured-vascular-endothelial-cells
#5
Takato Hara, Takayuki Kojima, Hiroka Matsuzaki, Takehiro Nakamura, Eiko Yoshida, Yasuyuki Fujiwara, Chika Yamamoto, Shinichi Saito, Toshiyuki Kaji
Organic-inorganic hybrid molecules constitute analytical tools used in biological systems. Vascular endothelial cells synthesize and secrete proteoglycans, which are macromolecules consisting of a core protein and glycosaminoglycan side chains. Although the expression of endothelial proteoglycans is regulated by several cytokines/growth factors, there may be alternative pathways for proteoglycan synthesis aside from downstream pathways activated by these cytokines/growth factors. Here, we investigated organic-inorganic hybrid molecules to determine a variant capable of analyzing the expression of syndecan-4, a transmembrane heparan-sulfate proteoglycan, and identified 1,10-phenanthroline (o-Phen) with or without zinc (Zn-Phen) or rhodium (Rh-Phen)...
February 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28208004/a-novel-partially-covered-self-expandable-metallic-stent-with-proximal-flare-in-patients-with-malignant-gastric-outlet-obstruction
#6
Naminatsu Takahara, Hiroyuki Isayama, Yousuke Nakai, Shuntaro Yoshida, Tomotaka Saito, Suguru Mizuno, Hiroshi Yagioka, Hirofumi Kogure, Osamu Togawa, Saburo Matsubara, Yukiko Ito, Natsuyo Yamamoto, Minoru Tada, Kazuhiko Koike
Background/Aims: Endoscopic placement of self-expandable metal stents (SEMSs) has emerged as a palliative treatment for malignant gastric outlet obstruction (GOO). Although covered SEMSs can prevent tumor ingrowth, frequent migration of covered SEMSs may offset their advantages in preventing tumor ingrowth. Methods: We conducted this multicenter, single-arm, retrospective study at six tertiary referral centers to evaluate the safety and efficacy of a partially covered SEMS with an uncovered large-bore flare at the proximal end as an antimigration system in 41 patients with symptomatic malignant GOO...
February 17, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28207964/impaired-nephrogenesis-in-neonatal-rats-with-oxygen-induced-retinopathy
#7
Mayu Nakagawa, Naoto Nishizaki, Amane Endo, Tomonosuke Someya, Yuta Saito, Akira Mizutani, Taichi Hara, Yayoi Murano, Koji Sakuraya, Satoshi Hara, Daisuke Umino, Daishi Hirano, Shuichiro Fujinaga, Yoshiyuki Ohtomo, Toshiaki Shimizu
OBJECTIVES: Preterm neonates are born while nephrogenesis is ongoing and are commonly exposed to factors in a hyperoxic environment that can impair renal development. Oxidative stress has also been implicated in the development of retinopathy of prematurity (ROP). The rat model of oxygen-induced retinopathy (OIR) is the most clinically relevant model of ROP because its biologic features closely resemble those of ROP in preterm infants. We investigated impaired renal development in a rat model of OIR...
February 16, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28207638/association-of-local-intrapulmonary-production-of-antibodies-specific-to-donor-major-histocompatibility-complex-class-i-with-the-progression-of-chronic-rejection-of-lung-allografts
#8
Ei Miyamoto, Hideki Motoyama, Masaaki Sato, Akihiro Aoyama, Toshi Menju, Kei Shikuma, Terumasa Sowa, Akihiko Yoshizawa, Masao Saito, Akihiro Takahagi, Satona Tanaka, Mamoru Takahashi, Keiji Ohata, Takeshi Kondo, Kyoko Hijiya, Toyofumi F Chen-Yoshikawa, Hiroshi Date
BACKGROUND: Antibody-mediated rejection may lead to chronic lung allograft dysfunction, but antibody-mediated rejection may develop in the absence of detectable donor-specific antibody (DSA) in recipient serum. This study investigated whether humoral immune responses develop not only systemically but locally within rejected lung allografts, resulting in local production of DSA. METHODS: Lewis rats received orthotopic left lung transplantation from Lewis (syngeneic control) or Brown-Norway (major histocompatibility complex-mismatched allogeneic) donor rats...
February 15, 2017: Transplantation
https://www.readbyqxmd.com/read/28206706/efficient-synthesis-of-1-4-bis-heteroatom-substituted-tetraselanylbenzenes-via-1-4-dilithiation-of-hexaselanylbenzene-and-investigation-on-their-electronic-properties
#9
Masaichi Saito, Shunsuke Furukawa, Masahiro Fujita
We successfully synthesized mono- and bis-substituted polyselanylbenzenes 3 and 5 via mono- and dilithiation of hexakis(phenylselanyl)benzene (1), respectively. Introduction of various heteroatom functionalities into hexaselanylbenzene changed the electronic properties dependent on the σ-symmetric circular orbitals that were formed by the interactions between neighboring heteroatoms. In the cyclic voltammetry and theoretical studies on bis-heteroatom-substituted benzenes 5, the extent of the interactions in the circular orbitals with σ-symmetry affected the stability of the cationic species of 5...
February 16, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28205646/connexin30-3-is-expressed-in-mouse-embryonic-stem-cells-and-is-responsive-to-leukemia-inhibitory-factor
#10
Mikako Saito, Yuma Asai, Keiichi Imai, Shoya Hiratoko, Kento Tanaka
The expression of 19 connexin (Cx) isoforms was observed in the mouse embryonic stem (ES) cell line, EB3. Their expression patterns could be classified into either pluripotent state-specific, differentiating stage-specific, or non-specific Cxs. We focused on Cx30.3 as typical of the first category. Cx30.3 was pluripotent state-specific and upregulated by leukemia inhibitory factor (LIF), a specific cytokine that maintains the pluripotent state of ES cell, via a Jak signaling pathway. Cx30.3 protein was localized to both the cell membrane and cytosol...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28205420/tetrabutylammonium-salts-of-aluminum-iii-and-gallium-iii-phthalocyanine-radical-anions-bonded-with-fluoren-9-olato%C3%AF-anions-and-indium-iii-bromide-phthalocyanine-radical-anions
#11
Dmitri Konarev, Salavat Khasanov, Manabu Ishikawa, Yoshiaki Nakano, Akihiro Otsuka, Hideki Yamochi, Gunzi Saito, Rimma N Lyubovskaya
Reduction of aluminum(III), gallium(III) and indium(III) chloride phthalocyanines by sodium fluorenone ketyl in the presence of tetrabutylammonium cations yielded crystalline salts (Bu4N+)2[M(III)(HFl-O-)(Pc*3-)](*-)(Br-).1.5C6H4Cl2 (M = Al (1), Ga(2), HFl-O- = Fluoren-9-olato- anion) and (Bu4N+)[In(III)Br(Pc*3-)]*-.0.875C6H4Cl2.0.125C6H14 (3). The salts contain Pc(*3-) radical anions with negatively charged phthalocyanine macrocycles evidenced by the presence of intense bands of (Pc*3-) in the NIR range and noticeable blue shift of both Q- and Soret bands of phthalocyanine...
February 15, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28205315/prevention-of-chemotherapy-induced-vomiting-in-children-receiving-multiple-day-cisplatin-chemotherapy-a-hospital-based-retrospective-cohort-study
#12
Kenji Kishimoto, Keiichiro Kawasaki, Atsuro Saito, Aiko Kozaki, Toshiaki Ishida, Daiichiro Hasegawa, Yoshiyuki Kosaka
BACKGROUND: Optimal prevention of chemotherapy-induced vomiting (CIV) has not been established for patients receiving cisplatin in divided doses. The aim of this study was to describe the incidence and risk factors of CIV in children who received multiple-day cisplatin chemotherapy. PROCEDURE: A total of 24 consecutive pediatric patients (age 0-19 years) who received multiple-day cisplatin chemotherapy in our hospital were enrolled. Patients with relapsed disease or primary intracranial tumor and those who received concurrent radiation therapy were excluded...
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28205287/upstream-regulation-for-initiation-of-restricted-shh-expression-in-the-chick-limb-bud
#13
Haruka Matsubara, Daisuke Saito, Gembu Abe, Hitoshi Yokoyama, Takayuki Suzuki, Koji Tamura
Background The organizing center, which serves as a morphogen source, has crucial functions in morphogenesis in animal development. The center is necessarily located in a certain restricted area in the morphogenetic field, and there are several ways in which an organizing center can be restricted. The organizing center for limb morphogenesis, the ZPA (zone of polarizing activity), specifically expresses the Shh gene and is restricted to the posterior region of the developing limb bud. Results The prepattern along the limb antero-posterior axis, provided by anterior Gli3 expression and posterior Hand2 expression, seems insufficient for the initiation of Shh expression restricted to a narrow, small spot in the posterior limb field...
February 16, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28205070/clinicopathological-significance-of-ganglioside-dsgb5-expression-in-renal-cell-carcinoma
#14
Jun Itoh, Akihiro Ito, Shuichi Shimada, Yoshihide Kawasaki, Narihiko Kakoi, Hideo Saito, Koji Mitsuzuka, Mika Watanabe, Makoto Satoh, Seiichi Saito, Yoichi Arai
Disialosyl globopentaosylceramide (DSGb5) is a ganglioside originally isolated from tissue extracts of renal cell carcinoma (RCC) with metastasis. Previous in vitro experiments have suggested that DSGb5 promotes metastasis by enhancing the migration of RCC cells and downregulating NK cell cytotoxicity against RCC cells. In this study, we investigated the clinicopathological significance of DSGb5 expression in RCC and outcomes of RCC patients. A total of 156 RCC patients who underwent surgical treatments at our hospital from January 2007 through December 2012 were analyzed in this study...
February 15, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28204779/development-of-real-time-radiation-exposure-dosimetry-system-using-synthetic-ruby-for-interventional-radiology
#15
Yoshiyuki Hosokai, Kenki Matsumoto, Masataka Kozakai, Kaito Takahashi, Akihito Usui, Thet Pe Win, Kenzo Muroi, Haruo Saito
No abstract text is available yet for this article.
February 14, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28203135/successful-treatment-of-hepatocellular-carcinoma-complicated-by-fanconi-anemia
#16
Koji Takahashi, Eiichiro Suzuki, Masayuki Yokoyama, Masanori Inoue, Toru Wakamatsu, Tomoko Saito, Yuko Kusakabe, Sadahisa Ogasawara, Yoshihiko Ooka, Akinobu Tawada, Yuhei Nagao, Chiaki Nakaseko, Tetsuhiro Chiba
A 42-year-old woman with liver tumors was referred to our hospital. Her condition was complicated by Fanconi anemia, and she had undergone total laryngectomy 8 years ago. On admission, contrast-enhanced computed tomography revealed hypervascular tumors in the right hepatic lobe. Ultrasound-guided tumor biopsy revealed that the tumor comprised moderately differentiated hepatocellular carcinoma. Although the patient exhibited preserved liver function (Child-Pugh A), complete blood count revealed severe pancytopenia...
January 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28203044/a-case-of-sitosterolemia-due-to-compound-heterozygous-mutations-in-abcg5-clinical-features-and-treatment-outcomes-obtained-with-colestimide-and-ezetimibe
#17
Sahoko Ono, Junko Matsuda, Aki Saito, Takenobu Yamamoto, Wataru Fujimoto, Hitomi Shimizu, Sumito Dateki, Kazunobu Ouchi
Sitosterolemia is a rare, autosomal recessively inherited disorder of lipid metabolism caused by mutations in the "ATP-binding cassette, subfamily G" member 5 and 8 proteins (encoded by the ABCG5 and ABCG8 genes, respectively), which play critical roles in the intestinal and biliary excretion of plant sterols. We report the clinical features and treatment outcomes of an 18-month-old Japanese girl with sitosterolemia, who presented with multiple linear and intertriginous xanthomas around the joint areas. Serum lipid analyses revealed elevated levels of total cholesterol (T-Chol: 866 mg/dL), low density lipoprotein-cholesterol (LDL-C: 679 mg/dL), and plant sterols (sitosterol: 24...
January 2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/28202596/the-3-hydroxyacyl-acp-dehydratase-component-of-the-plant-mitochondrial-fatty-acid-synthase-system
#18
Xin Guan, Yozo Okazaki, Andrew Lithio, Ling Li, Xuefeng Zhao, Huanan Jin, Dan Nettleton, Kazuki Saito, Basil J Nikolau
We report the characterization of the Arabidopsis 3-hydroxyacyl-acyl carrier protein (ACP) dehydratase (mtHD) component of the mitochondrial fatty acid synthase (mtFAS) system, encoded by AT5G60335. The mitochondrial localization and catalytic capability of mtHD were demonstrated with a green fluorescent protein (GFP) transgenesis experiment, and by in vivo complementation and in vitro enzymatic assays. RNAi knockdown lines with reduced mtHD expression exhibit traits typically associated with mtFAS mutants, namely a miniaturized morphological appearance, reduced lipoylation of lipoylated proteins, and altered metabolomes consistent with the reduced catalytic activity of lipoylated enzymes...
February 15, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28201898/a-rayleighian-approach-for-modeling-kinetics-of-ionic-transport-in-polymeric-media
#19
Rajeev Kumar, Jyoti P Mahalik, Vera Bocharova, Eric W Stacy, Catalin Gainaru, Tomonori Saito, Mallory P Gobet, Steve Greenbaum, Bobby G Sumpter, Alexei P Sokolov
We report a theoretical approach for analyzing impedance of ionic liquids (ILs) and charged polymers such as polymerized ionic liquids (PolyILs) within linear response. The approach is based on the Rayleigh dissipation function formalism, which provides a computational framework for a systematic study of various factors, including polymer dynamics, in affecting the impedance. We present an analytical expression for the impedance within linear response by constructing a one-dimensional model for ionic transport in ILs/PolyILs...
February 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28199095/interrelationship-among-the-fe-his-bond-strengths-oxygen-affinities-and-intersubunit-hydrogen-bonding-changes-upon-ligand-binding-in-%C3%AE-subunit-of-human-hemoglobin-the-alkaline-bohr-effect
#20
Shigenori Nagatomo, Miki Okumura, Kazuya Saito, Takashi Ogura, Teizo Kitagawa, Masako Nagai
Regulation of oxygen affinity of human adult hemoglobin (Hb A) at high pH, known as the alkaline Bohr effect, is essential to its physiological function. In this study structural mechanisms of the alkaline Bohr effect and pH-dependent O2 affinity changes are investigated with (1)H NMR, and visible- and UV-resonance Raman spectra of mutant Hbs, Hb M Iwate (αH87Y) and Hb M Boston (αH58Y). It was found that even though the O2 binding to the α subunits is forbidden in the mutant Hbs, the O2 affinity became higher at alkaline pH than at neutral pH and concomitantly, the Fe-His stretching frequency of the β subunits was shifted to higher values...
February 15, 2017: Biochemistry
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