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https://www.readbyqxmd.com/read/28220034/exhaled-and-nasal-nitric-oxide-in-relation-to-lung-function-blood-cell-counts-and-disease-characteristics-in-cystic-fibrosis
#1
Christina Krantz, Christer Janson, Annika Hollsing, Kjell Alving, Andrei Malinovschi
BACKGROUND: Patients with cystic fibrosis (CF) have similar or lower exhaled nitric oxide (FeNO) and lower nasal nitric oxide (nNO) levels than controls. There are divergent results on alveolar NO (CalvNO) concentrations in relation to CF. There are inconsistent results on correlation between different nitric oxide parameters and lung function and inflammation in CF. AIM: To compare FeNO, CalvNO and nNO levels between subjects with CF, asthma and healthy controls and to study whether these parameters are related to lung function, blood cell counts or clinical characteristics in CF patients...
March 20, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28199951/a-dioxidovanadium-v-complex-of-nno-donor-schiff-base-as-a-selective-inhibitor-of-protein-tyrosine-phosphatase-1b-synthesis-characterization-and-biological-activities
#2
Yuqi Jia, Liping Lu, Miaoli Zhu, Caixia Yuan, Shu Xing, Xueqi Fu
A new dioxidovanadium (V) complex, VO2(HPPCH) (1) (H2PPCH = N'-picolinoylpyridin-1-ium-2-carbohydrazonate) has been synthesized and characterized by elemental analysis, IR, X-ray diffraction analysis and electrospray ionization mass spectra. Complex 1 crystallized in the monoclinic system with space group P21/c. It potently inhibited PTP1B with IC50 of 0.13 μM, about 7, 15 and 125-fold stronger against PTP1B than over TCPTP, SHP-1 and SHP-2, displaying obvious selectivity against PTP1B. Western blotting analysis indicated that complex 1 effectively increased the phosphorylation of PTP1B substrates, especially the phosphorylation of IR/IGF 1R and IRS-1...
February 6, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28199369/nasal-nitric-oxide-in-unilateral-sinus-disease
#3
Chia-Hsiang Fu, Hsiao-Jung Tseng, Chi-Che Huang, Po-Hung Chang, Yi-Wei Chen, Ta-Jen Lee
Unilateral sinus disease (USD) can sometimes be difficult to accurately diagnose before surgery. The application of nasal nitric oxide (nNO) for USD diagnosis and its surgical outcome in USD has not been reported in the literature. We prospectively enrolled sixty-six USD patients who underwent endoscopic sinus surgery for fungal rhinosinusitis (n = 19), chronic rhinosinusitis (CRS) without nasal polyps (n = 13), CRS with nasal polyps (n = 12) and sinonasal mass lesions (n = 22). nNO levels were measured preoperatively and at three and six months postoperatively...
2017: PloS One
https://www.readbyqxmd.com/read/28171837/efficient-photoreductive-decomposition-of-n-nitrosodimethylamine-by-uv-iodide-process
#4
Zhuyu Sun, Chaojie Zhang, Xiaoyun Zhao, Jing Chen, Qi Zhou
N-nitrosodimethylamine (NDMA) has aroused extensive concern as a disinfection byproduct due to its high toxicity and elevated concentration levels in water sources. This study investigates the photoreductive decomposition of NDMA by UV/iodide process. The results showed that this process is an effective strategy for the treatment of NDMA with 99.2% NDMA removed within 10min. The depletion of NDMA by UV/iodide process obeyed pseudo-first-order kinetics with a rate constant (k1) of 0.60±0.03min(-1). Hydrated electrons (eaq(-)) generated by the UV irradiation of iodide were proven to play a critical role...
May 5, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28029746/respiratory-manifestations-in-38-patients-with-alstr%C3%A3-m-syndrome
#5
Caroline Boerwinkle, Jan D Marshall, Joy Bryant, William A Gahl, Kenneth N Olivier, Meral Gunay-Aygun
OBJECTIVES: Alström syndrome (AS) is a rare, multi-system condition characterized by retinal degeneration, sensorineural hearing loss, obesity, insulin-resistant diabetes, hypertriglyceridemia, cardiomyopathy, hepatorenal disease, and recurrent respiratory infections. It belongs to a group of genetic disorders known as primary ciliopathies, which includes autosomal dominant and recessive polycystic kidney diseases, as well as Joubert and Bardet-Biedl syndromes. Prior studies have suggested phenotypic overlap between primary ciliopathies affecting the non-motile, sensory cilia, and primary ciliary dyskinesia (PCD), a motile ciliopathy characterized by respiratory tract disease...
April 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27997189/influence-of-radical-bridges-on-electron-spin-coupling
#6
Torben Steenbock, David A Shultz, Martin L Kirk, Carmen Herrmann
Increasing interactions between spin centers in molecules and molecular materials is a desirable goal for applications such as single-molecule magnets for information storage or magnetic metal-organic frameworks for adsorptive separation and targeted drug delivery and release. To maximize these interactions, introducing unpaired spins on bridging ligands is a concept used in several areas where such interactions are otherwise quite weak, in particular, lanthanide-based molecular magnets and magnetic metal-organic frameworks...
December 20, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27894463/what-should-we-say-to-patients-with-unexplained-neurological-symptoms-how-explanation-affects-offence
#7
Juen Mei Ding, Richard A A Kanaan
OBJECTIVES: Unexplained neurological symptoms (UNS) are common presentations in neurology but there is no consensus as to what they should be called. This is important, as patient acceptance is a predictor of outcome and there is evidence that patients are unhappy with the terms used. Patient understanding of these terms may be limited, however, and, once explained, the terms may seem more or less offensive. We sought to elicit patients' views of 7 frequently used terms for UNS, and whether these changed once definitions were provided...
December 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27863128/one-component-aluminum-heteroscorpionate-catalysts-for-the-formation-of-cyclic-carbonates-from-epoxides-and-carbon-dioxide
#8
Javier Martínez, José A Castro-Osma, Carlos Alonso-Moreno, Antonio Rodríguez-Diéguez, Michael North, Antonio Otero, Agustín Lara-Sánchez
New neutral and zwitterionic chiral NNO-donor scorpionate ligands 1 and 2 were designed to obtain new mononuclear and dinuclear NNO-heteroscorpionate aluminum complexes. Reaction of 1 with [AlR3 ] (R=Me, Et) in a 1:1 or 1:2 molar ratio afforded the neutral mononuclear alkyl complexes [AlR2 (κ(2) -bpzappe)] {R=Me (3), Et (4); bpzappeH=2,2-bis(3,5-dimethylpyrazol-1-yl)-1-[4-(dimethylamino)phenyl]-1-phenylethanol} and bimetallic complexes [{AlR2 (κ(2) -bpzappe)}(μ-O){AlR3 }] [R=Me (5), Et (6)]. By reaction of complexes 3-6 with PhCH2 Br, mononuclear and dinuclear cationic aluminum complexes [AlR2 (κ(2) -bbpzappe)]Br {R=Me (7), Et (8); bbpzappeH=N-benzyl-4-[2,2-bis(3,5-dimethyl-1H-pyrazol-1-yl)-1-hydroxy-1-phenylethyl]-N,N-dimethylbenzenaminium bromide} and [{AlR2 (κ(2) -bbpzappe)}(μ-O){AlR3 }]Br [R=Me (9), Et (10)] were synthesized...
March 22, 2017: ChemSusChem
https://www.readbyqxmd.com/read/27845934/localization-driven-metal-insulator-transition-in-epitaxial-hole-doped-nd1-x-sr-x-nio3-ultrathin-films
#9
Le Wang, Lei Chang, Xinmao Yin, Andrivo Rusydi, Lu You, Yang Zhou, Liang Fang, Junling Wang
Advances in thin film growth technologies make it possible to obtain ultra-thin perovskite oxide films and open the window for controlling novel electronic phases for use in functional nanoscale electronics, such as switches and sensors. Here, we study the thickness-dependent transport characteristics of high-quality ultrathin Nd0.9Sr0.1NiO3 (Sr-NNO) films, which were grown on LaAlO3 (0 0 1) single-crystal substrates by using pulsed laser deposition method. Thick Sr-NNO films (25 unit cells) exhibit metallic behavior with the electrical resistivity following the T ( n) (n  <  2) law corresponding to a non-Fermi liquid system, while a temperature driven metal-insulator transition (MIT) is observed with films of less than 15 unit cells...
January 18, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27785596/the-diagnostic-accuracy-of-chromatic-pupillary-light-responses-in-diseases-of-the-outer-and-inner-retina
#10
Paul Richter, Helmut Wilhelm, Tobias Peters, Holger Luedtke, Anne Kurtenbach, Herbert Jaegle, Barbara Wilhelm
PURPOSE: To compare the chromatic pupillary light responses (PLR) in healthy subjects with those from patients with diseases of the outer or inner retina under various stimulus conditions, and to ascertain the parameters required to optimally distinguish between disease and control groups. METHODS: Fifteen patients with retinitis pigmentosa (RP), 19 patients with optic nerve disease (ON), and 16 healthy subjects were enrolled in this prospective study. ON included optic neuritis (NNO) and non-arteritic anterior ischemic optic neuropathy (NAION)...
March 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27753120/longitudinal-analysis-of-inflammatory-biomarkers-during-acute-rhinosinusitis
#11
Timo J Autio, Timo Koskenkorva, Tuomo K Leino, Petri Koivunen, Olli-Pekka Alho
OBJECTIVE: To illuminate the pathophysiology of acute rhinosinusitis (ARS) with sequential monitoring of inflammatory biomarkers during an ARS episode and to clarify their diagnostic usability in bacterial ARS. STUDY DESIGN: Inception cohort study with 50 conscripts with ARS. METHODS: We collected peripheral blood high-sensitive C-reactive protein (hs-CRP), white blood cell (WBC), procalcitonin, and nasal nitric oxide (nNO) counts at 2 to 3 and 9 to 10 days of symptoms during an ARS episode...
February 2017: Laryngoscope
https://www.readbyqxmd.com/read/27692146/primary-ciliary-dyskinesia-in-israel-prevalence-clinical-features-current-diagnosis-and-management-practices
#12
Revital Abitbul, Israel Amirav, Hannah Blau, Soliman Alkrinawi, Micha Aviram, David Shoseyov, Lea Bentur, Avraham Avital, Chaim Springer, Moran Lavie, Dario Prais, Husein Dabbah, Nael Elias, Arnon Elizur, Shmuel Goldberg, Avigdor Hevroni, Eitan Kerem, Anthony Luder, Yehudah Roth, Malena Cohen-Cymberknoh, Marta Ben Ami, Avigdor Mandelberg, Galit Livnat, Elie Picard, Joseph Rivlin, Moshe Rotschild, Ruth Soferman, Niki T Loges, Heike Olbrich, Claudius Werner, Alexander Wolter, Martina Herting, Julia Wallmeier, Johanna Raidt, Heymut Omran, Huda Mussaffi
BACKGROUND: Primary Ciliary Dyskinesia (PCD) is rare and its features in Israel have not been described. AIMS: to assess prevalence utilizing state-of-the-art diagnostic techniques, and describe clinical features, diagnostic and management practices in Israel. METHODS: A national multicenter study from 2012 to 2013 recruited patients diagnosed or suspected of having PCD. Diagnosis was verified using: nasal Nitric Oxide (nNO); High-speed Video Microscope Analysis (HVMA); Transmission Electron Microscopy (TEM) of cilia; Immuno-fluorescence staining (IF) for ciliary proteins, and genetic analysis...
October 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27531163/localized-mixed-valence-and-redox-activity-within-a-triazole-bridged-dinucleating-ligand-upon-coordination-to-palladium
#13
Daniël L J Broere, Raoul Plessius, Joanne Tory, Serhiy Demeshko, Bas de Bruin, Maxime A Siegler, Frantisek Hartl, Jarl Ivar van der Vlugt
The new dinucleating redox-active ligand (L(H4) ), bearing two redox-active NNO-binding pockets linked by a 1,2,3-triazole unit, is synthetically readily accessible. Coordination to two equivalents of Pd(II) resulted in the formation of paramagnetic (S=1/2 ) dinuclear Pd complexes with a κ(2) -N,N'-bridging triazole and a single bridging chlorido or azido ligand. A combined spectroscopic, spectroelectrochemical, and computational study confirmed Robin-Day Class II mixed-valence within the redox-active ligand, with little influence of the secondary bridging anionic ligand...
September 19, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27525360/reversible-redox-chemistry-and-catalytic-c-sp-3-h-amination-reactivity-of-a-paramagnetic-pd-complex-bearing-a-redox-active-o-aminophenol-derived-nno-pincer-ligand
#14
Daniël L J Broere, Nicolaas P van Leest, Bas de Bruin, Maxime A Siegler, Jarl Ivar van der Vlugt
The synthesis, spectroelectrochemical characterization (ultraviolet-visible and nuclear magnetic resonance), solid state structures, and computational metric parameters of three isostructural PdCl(NNO) complexes 1 [PdCl(NNO(ISQ))], 2 {[PdCl(NNO(AP))](-)}, and 5 {[PdCl(NNO(IBQ))](+)} (NNO = o-aminophenol-derived redox-active ligand with a pendant pyridine) with different NNO oxidation states are described. The reduced diamagnetic complex 2 readily reacts with halogenated solvents, including lattice solvent from crystalline pure material, as supported by spectroscopic data and density functional theory calculations...
September 6, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27479795/dinuclear-and-trinuclear-nickel-complexes-as-effective-catalysts-for-alternating-copolymerization-on-carbon-dioxide-and-cyclohexene-oxide
#15
Chen-Yen Tsai, Fu-Yin Cheng, Kuan-Yeh Lu, Jung-Tsu Wu, Bor-Hunn Huang, Wei-An Chen, Chu-Chieh Lin, Bao-Tsan Ko
A series of novel nickel complexes 1-9 supported by NNO-tridentate Schiff-base derivatives have been synthesized and characterized. Treatment of the pro-ligands [L(1)-H = 2,4-di-tert-butyl-6-(((2-(dimethylamino)ethyl)imino)methyl)phenol, L(2)-H = 2-(((2-(dimethylamino)ethyl)imino)methyl)-4,6-bis(2-phenylpropan-2-yl)phenol, L(3)-H = 2-(((2-(dimethylamino)ethyl)imino)methyl)phenol] with Ni(OAc)2·4H2O in refluxing ethanol afforded mono- or bimetallic nickel complexes {[(L(1))Ni(OAc)] (1); (L(2))Ni(OAc)] (2); (L(3))2Ni2(OAc)2(H2O)] (3)}...
August 15, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27435378/synthesis-of-tetrazino-tetrazine-1-3-6-8-tetraoxide-ttto
#16
Michael S Klenov, Alexey A Guskov, Oleg V Anikin, Aleksandr M Churakov, Yurii A Strelenko, Ivan V Fedyanin, Konstantin A Lyssenko, Vladimir A Tartakovsky
This study presents the first synthesis and characterization of a new high energy compound [1,2,3,4]tetrazino[5,6-e][1,2,3,4]tetrazine 1,3,6,8-tetraoxide (TTTO). It was synthesized in ten steps from 2,2-bis(tert-butyl-NNO-azoxy)acetonitrile. The synthetic strategy was based on the sequential closure of two 1,2,3,4-tetrazine 1,3-dioxide rings by the generation of oxodiazonium ions and their intramolecular coupling with tert-butyl-NNO-azoxy groups. The TTTO structure was confirmed by single-crystal X-ray.
September 12, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27425415/sphenopalatine-ganglion-acupuncture-improves-nasal-ventilation-and-modulates-autonomic-nervous-activity-in-healthy-volunteers-a-randomized-controlled-study
#17
Kuiji Wang, Luquan Chen, Yang Wang, Chengshuo Wang, Luo Zhang
The study aimed to assess the effects of Sphenopalatine ganglion (SPG) acupuncture on nasal ventilation function and autonomic nervous system in health volunteers. 39 healthy subjects were randomly assigned to either active SPG acupuncture group (AA group) or sham-SPG acupuncture group (SA group). All subjects were assessed for self-reported nasal ventilation, nasal patency (nasal airway resistance (NAR) and nasal cavity volume (NCV), exhaled nasal nitric oxide (nNO), and neuropeptides (substance P(SP), vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY)) in nasal secretions at baseline, 30 minutes, 2 hours, and 24 hours after acupuncture...
July 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27381923/preparation-of-3-azoindoles-and-3-hydrazonoindolin-2-imines-as-well-as-their-applications-as-nno-pincer-ligands-for-boron
#18
Hualong Ding, Zhixing Peng, Jinjin Wang, Ping Lu, Yanguang Wang
Potassium carbonate-promoted coupling reactions between 3-diazoindolin-2-imines and nucleophiles were tested. By respectively applying 2-naphthalenols and 2-arylacetates as nucleophiles, 3-azoindoles and 3-hydrazonoindolin-2-imines were obtained in excellent yields. Moreover, 3-azoindol-2-amines could be used as NNO pincer ligands for boron and resulted in the formation of hexacycleborofluorides with their absorption around 580 nm in dichloromethane.
August 7, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27355194/synthesis-and-biological-evaluation-of-n-2-substituted-2-4-diamino-6-cyclohexylmethoxy-5-nitrosopyrimidines-and-related-5-cyano-nno-azoxy-derivatives-as-cyclin-dependent-kinase%C3%A2-2-cdk2-inhibitors
#19
Daniela Cortese, Konstantin Chegaev, Stefano Guglielmo, Lan Z Wang, Bernard T Golding, Céline Cano, Roberta Fruttero
The potent and selective cyclin-dependent kinase 2 (CDK2) inhibitor NU6027 (6-cyclohexylmethoxy-5-nitroso-2,4-diaminopyrimidine) was used as the lead for the synthesis of a series of analogues in order to provide further insight into the structure-activity relationships for 2,4-diaminopyrimidine CDK2 inhibitors. Aliphatic amino substituents were introduced at position 2. The use of linear or less sterically hindered amines gave rise to compounds endowed with slightly better activity than the lead; on the other hand, the compounds were less active if a bulkier amino substituent was used...
August 19, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27284310/circulating-micrornas-indicate-cardioprotection-by-sevoflurane-inhalation-in-patients-undergoing-off-pump-coronary-artery-bypass-surgery
#20
Xiao Liu, Xiaopeng Liu, Ruike Wang, Hui Luo, Gang Qin, L U Wang, Zhi Ye, Qulian Guo, E Wang
In patients undergoing off-pump coronary artery bypass surgery (OPCAB), it is important to attenuate myocardium injury during the surgery. The present study aimed to observe the cardioprotection induced by sevoflurane induction and maintenance compared with propofol intravenous anesthesia, and to detect its potential protection against acute myocardial injury with sensitive biomarkers. In total, 36 patients undergoing OPCAB were randomly assigned into two groups, receiving sevoflurane (n=18) or propofol (n=18) as the induction and maintenance anesthetic agent...
June 2016: Experimental and Therapeutic Medicine
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