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https://www.readbyqxmd.com/read/29310239/an-ortho-aldehyde-modified-probe-to-image-thiols-in-living-cells-with-enhanced-selectivity
#1
Panfei Xing, Yuchen Shi, Qiu Li, Yanxian Feng, Lei Dong, Chunming Wang
Developing fluorescent probes to image thiols in the living system may provide powerful tools to study the functions of thiol-containing biological molecules. In this study, we report the design and evaluation of a novel turn-on fluorescent probe NQNO for selective detection of thiols in living cells. By introducing an ortho-aldehyde group to NNO, a conventional compound representing a class of thiol-imaging strategy, we obtained NQNO with enhanced selectivity for thiols over the major interferent hydrogen sulfide (H2S)...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29276419/lessons-from-unilateral-loss-of-cilia-early-nasal-nitric-oxide-gas-mixing-and-the-role-of-sinus-patency-in-determining-nasal-nitric-oxide
#2
Kenneth Rodriguez, Benjamin Gaston, Jay Wasman, Nadzeya Marozkina
Nasal nitric oxide (nNO) measurement is a diagnostic test for primary ciliary dyskinesia (PCD). Here, we have shown the development of unilateral PCD-like symptoms associated with low nNO. A 60-year-old man had been previously healthy but developed unilateral, severe pansinusitis. He required surgical drainage of all left sinuses, and biopsies showed loss of the ciliated epithelium. At 4 weeks, he had unilateral (left-sided), profuse, clear rhinorrhea characteristic of PCD, and his surgical ostia were all patent endoscopically...
2017: Clinical Medicine Insights. Ear, Nose and Throat
https://www.readbyqxmd.com/read/29222862/photocytotoxic-copper-ii-complexes-with-schiff-base-scaffolds-for-photodynamic-therapy
#3
Rong-Kai Lin, Chin-I Chiu, Cho-Han Hsu, Ying-Ju Lai, Parthiban Venkatesan, Po-Han Huang, Ping-Shan Lai, Chu-Chieh Lin
Photodynamic therapy (PDT) is a promising and minimally invasive method for the treatment of superficial diseases, and photosensitizers with high phototoxicity indexes (defined as (IC50Dark)/(IC50Irridation)) are essential for the development of ideal photosensitizing properties for this technology. In this study, a series of photocytotoxic copper(II) complexes [Cu(RQYMP)(dppn)] (QYMP = NNO-tridentate Schiff base derivatives, dppn = benzo[i]dipyrido[3,2-a;2´,3´-c]-phenazine) were reported, with their respective structural confirmations by mass spectrometry and FTIR spectroscopy...
December 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29212650/low-nasal-no-in-congenital-heart-disease-with-systemic-right-ventricle-and-postcardiac-transplantation
#4
Phillip S Adams, Maliha Zahid, Omar Khalifa, Brian Feingold, Cecilia W Lo
BACKGROUND: NO bioavailability has not been systematically examined in congenital heart disease (CHD). To assess NO in patients with CHD, we measured nasal NO (nNO) generated by the nasal epithelia, given blood NO is difficult to measure (half-life, <2 ms). Given NO's role in hemodynamic regulation and the association of NO bioavailability with heart failure risk, we hypothesized NO levels may differ with varying severity of CHD physiologic characteristics. METHODS AND RESULTS: Six-hundred eighteen subjects, 483 with CHD and 135 controls, had nNO measured noninvasively via the nares using American Thoracic Society/European Respiratory Society guidelines...
December 6, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29177705/acid-facilitated-product-release-from-a-mo-iv-center-relevance-to-oxygen-atom-transfer-reactivity-of-molybdenum-oxotransferases
#5
Feifei Li, Marat R Talipov, Chao Dong, Sofia Bali, Keying Ding
We report that pyridinium ions (HPyr+) accelerate the conversion of [Tp*MoIVOCl(OPMe3)] (1) to [Tp*MoIVOCl(NCCH3)] (2) by 103-fold, affording 2 in near-quantitative yield; Tp* = hydrotris(3,5-dimethyl-1-pyrazolyl)borate. This novel reactivity and the mechanism of this reaction were investigated in detail. The formation of 2 followed pseudo-first-order kinetics, with the observed pseudo-first-order rate constant (k obs) linearly correlated with [HPyr+]. An Eyring plot revealed that this HPyr+-facilitated reaction has a small positive value of ∆S ‡ indicative of a dissociative interchange (Id) mechanism, different from the slower associative interchange (Ia) mechanism in the absence of HPyr+ marked with a negative ∆S ‡...
November 25, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29077199/accumulation-and-distribution-characteristics-of-biomass-and-nitrogen-in-bitter-gourd-momordica-charantia-l-under-different-fertilization-strategies
#6
Baige Zhang, Mingzhu Li, Qiang Li, Jian Cao, Changyuan Zhang, Fusuo Zhang, Xinping Chen
BACKGROUND: The elemental uptake and allocation patterns of crops create insight for nutrient management. Two-year field experiments were conducted to determine the growth and nitrogen (N) uptake patterns of bitter gourd and to evaluate different N management strategies. Two N practices during the nursery stage, namely, the conventional fertilizer method (Scon) and the controlled-release fertilizer management method (Scrf), combined with three N management strategies after transplanting, namely, zero N fertilizer application (Nno), the conventional strategy (Ncon) and the systematic N management strategy (Nopt) were assessed...
October 27, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29068018/mono-and-binuclear-chiral-n-n-o-scorpionate-zinc-alkyls-as-efficient-initiators-for-the-rop-of-rac-lactide
#7
Antonio Otero, Juan Fernández-Baeza, Luis F Sánchez-Barba, Sonia Sobrino, Andrés Garcés, Agustín Lara-Sánchez, Ana M Rodríguez
The preparation of new chiral bis(pyrazol-1-yl)methane-based N,N,O-donor scorpionate ligands in the form of the alcohol compounds bpzampeH (1) {2,2-bis(3,5-dimethylpyrazol-1-yl)-1-[4-(dimethylamino)phenyl]ethanol}, bpzaepeH (2) {2,2-bis(3,5-dimethylpyrazol-1-yl)-1-[4-(diethylamino)phenyl]ethanol}, and bpzimeH (3) {2,2-bis(3,5-dimethylpyrazol-1-yl)-1-[1-methyl-1H-imidazol-2-yl]ethanol} has been carried out by the 1,2-addition reactions of a series of aldehydes. These new chiral heteroscorpionate ligands reacted with [ZnR2] (R = Me, Et, CH2SiMe3) in a 1 : 1 molar ratio in toluene to give the mononuclear monoalkyl zinc complexes [Zn(R)(κ(3)-NNO)] (4-12)...
November 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29056267/airway-ciliary-dysfunction-association-with-adverse-postoperative-outcomes-in-nonheterotaxy-congenital-heart-disease-patients
#8
Eileen Stewart, Phillip S Adams, Xin Tian, Omar Khalifa, Peter Wearden, Maliha Zahid, Cecilia W Lo
OBJECTIVE: Heterotaxy (HTX) congenital heart disease (CHD) patients with ciliary dysfunction (CD) have been shown to have increased postoperative respiratory morbidity. We hypothesized that non-HTX CHD infants with CD also will have increased postoperative morbidity, particularly respiratory complications. METHODS: Sixty-three infants with non-HTX CHD undergoing cardiac surgery were enrolled. Tests commonly used to assess for CD, nasal nitric oxide (nNO) measurements and nasal epithelial ciliary motion (CM) assessment, were obtained...
September 20, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29032923/is-it-necessary-to-dissect-the-posterior-lymph-nodes-along-the-splenic-vessels-during-total-gastrectomy-with-d2-lymphadenectomy-for-advanced-gastric-cancer
#9
Jian-Xian Lin, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin
BACKGROUND: D2 lymphadenectomy including No.10 lymph nodes (LNs) is the standard procedure for treating advanced gastric cancer (AGC) via total gastrectomy. However, there was no research focusing on the posterior LN dissection along the splenic vessels (No.10p LNs). This study is performed to assess the effect of dissecting No.10p LNs. METHODS: We analyzed 404 consecutive gastric cancer patients who underwent laparoscopic total gastrectomy (LTG) with D2 lymphadenectomy...
September 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29025172/-anti-myelin-oligodendrocyte-glycoprotein-antibodies-in-paediatric-patients-with-optic-neuritis
#10
Helmut Tegetmeyer, Andreas Merkenschlager
Background Myelin oligodendrocyte glycoprotein (MOG) is located on the surface of oligodendrocytes and myelin in the central nervous system. MOG-IgG is associated with acute disseminated encephalomyelitis (ADEM), relapsing and bilateral optic neuritis (NNO), and transverse myelitis (TM) in both paediatric and adult patients. The combination of NNO and TM or other inflammatory brain lesions is a typical feature of neuromyelitis optica spectrum disorders (NMO-SD) which are associated with specific pathogenic autoantibodies against the water channel aquaporin-4 (AQP4-IgG)...
October 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28987087/detection-and-structural-characterization-of-nitrosamide-h2nno-a-central-intermediate-in-denox-processes
#11
Michael C McCarthy, Kin Long Kelvin Lee, John F Stanton
The structure and bonding of H2NNO, the simplest N-nitrosamine, and a key intermediate in deNOx processes, have been precisely characterized using a combination of rotational spectroscopy of its more abundant isotopic species and high-level quantum chemical calculations. Isotopic spectroscopy provides compelling evidence that this species is formed promptly in our discharge expansion via the NH2 + NO reaction and is collisionally cooled prior to subsequent unimolecular rearrangement. H2NNO is found to possess an essentially planar geometry, an NNO angle of 113...
October 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28937239/nasal-nitric-oxide-in-healthy-adults-reference-values-and-affecting-factors
#12
M Antosova, D Mokra, I Tonhajzerova, P Mikolka, P Kosutova, M Mestanik, L Pepucha, J Plevkova, T Buday, V Calkovsky, A Bencova
Nitric oxide (NO) is an important endogenous mediator with significant role in the respiratory system. Many endogenous and exogenous factors influence the synthesis of NO and its level is significantly changed during the inflammation. Analysis of nasal nitric oxide (nNO) is not validated so far as the diagnostic method. There is a lack of reference values with possible identification of factors modulating the nNO levels. In healthy adult volunteers (n=141) we studied nasal NO values by NIOX MINO® (Aerocrine, Sweden) according to the recommendations of the ATS & ERS...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28927489/role-of-exhaled-nasal-nitric-oxide-in-distinguishing-between-chronic-rhinosinusitis-with-and-without-nasal-polyps
#13
(no author information available yet)
BACKGROUND: Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP) nasal polypsis a global health concern. Several clinical biomarkers, such as inhaled carbon monoxide and exhaled nitric oxide (NO), have been studied to assess the presence and degree of inflammation in the airway mucosa. OBJECTIVE: To evaluate the clinical application of exhaled nasal NO (nNO) in distinguishing between CRSwNP and CRSsNP in consideration of the atopic status of patients...
September 19, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28783864/nasal-nitric-oxide-measurement-and-a-modified-picadar-score-for-the-screening-of-primary-ciliary-dyskinesia-in-adults-with-bronchiectasis
#14
J Rademacher, A Buck, N Schwerk, M Price, J Fuge, T Welte, F C Ringshausen
Background Determining the underlying diagnosis is essential for the targeted and specific treatment of bronchiectasis. Primary ciliary dyskinesia (PCD) is a rare genetic disease, which is characterized by abnormalities in ciliary structure and/or function and which may result in bronchiectasis. The disease is probably underestimated among adults with bronchiectasis due to the fact that extensive diagnostic testing is required and that the recognition of PCD is low. Objective To evaluate a feasible screening algorithm for PCD among adults with bronchiectasis...
August 2017: Pneumologie
https://www.readbyqxmd.com/read/28731081/metal-mediated-reactions-between-dialkylcyanamides-and-acetamidoxime-generate-unusual-nitrosoguanidinate-nickel-ii-complexes
#15
Zarina M Bikbaeva, Alexander S Novikov, Vitalii V Suslonov, Nadezhda A Bokach, Vadim Yu Kukushkin
The nitrosoguanidinate complexes [Ni{NH[double bond, length as m-dash]C(NR2)NN(O)}2] (R2 = Me21, (CH2)4O 2, (CH2)43, (CH2)54, (Me)Ph 5, Ph26, (p-MeC6H4)27) were obtained in low-to-moderate (12-26%) yields but reproducible yields in an unexpected metal-mediated reaction in MeOH between the nickel salt NiCl2·2H2O, N,N-disubstituted cyanamides NCNR2, and the amidoxime MeC([double bond, length as m-dash]NOH)NH2. These complexes were formed along with a spectrum of cyanamide-oxime coupling products. The IR and X-ray data indicate the delocalization within the NNO and NCN systems of the nitrosoguanidinate ligand...
August 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28646193/fabrication-of-nitrogen-doped-nano-onions-and-their-electrocatalytic-activity-toward-the-oxygen-reduction-reaction
#16
E Y Choi, C K Kim
Nitrogen-doped nano-onions (NNO) were prepared as electrocatalytic materials for the oxygen reduction reaction (ORR). The nano-onions (NO), spherical graphitic material particles, were prepared by pyrolysis of nanodiamonds (ND). Oxidized NO (ONO) was prepared from NO by a modified Hummers' method, and this was mixed with urea, followed by pyrolysis, resulting in the formation of NNO. The nitrogen content and molar ratio of nitrogen-containing groups in the NNOs were varied by controlling the oxygen content of ONO to explore the effect of nitrogen content on the ORR activity...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28579561/normal-values-of-offline-exhaled-and-nasal-nitric-oxide-in-healthy-children-and-teens-using-chemiluminescence
#17
Awen Menou, Diane Babeanu, Henry-Nicolas Paruit, Aline Ordureau, Sophie Guillard, Arnaud Christian Chambellan
Nitric oxide (NO) can be used to detect respiratory or ciliary diseases. Fractional exhaled nitric oxide (FeNO) measurement can reflect ongoing eosinophilic airway inflammation and has a diagnostic utility as a test for asthma screening and follow-up while nasal nitric oxide (nNO) is a valuable screening tool for the diagnosis of Primary Ciliary Dyskinesia (PCD). The possibility to collect airway gas samples in an offline manner offers the advantage to extend these measures and improve the screening and management of these diseases, but normal values from healthy children and teens remain sparse...
June 5, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28495666/how-to-use-nasal-nitric-oxide-in-a-child-with-suspected-primary-ciliary-dyskinesia
#18
Kim Simpson, Malcolm Brodlie
Measuring nasal nitric oxide (nNO) is increasingly used as part of testing for primary ciliary dyskinesia (PCD). The diagnosis of PCD is often delayed until after bronchiectasis is established and auditory damage has occurred. It is important that all paediatricians are aware of clinical features that are suggestive of PCD that should prompt diagnostic testing. nNO levels are recognised to be low in people with PCD and results generated by static chemiluminescence analysers using velum closure technique in older children have good sensitivity and specificity...
May 11, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/28488706/impact-of-aryloxy-initiators-on-the-living-and-immortal-polymerization-of-lactide
#19
L-E Chile, T Ebrahimi, A Wong, D C Aluthge, S G Hatzikiriakos, P Mehrkhodavandi
This report describes two different methodologies for the synthesis of aryl end-functionalized poly(lactide)s (PLAs) catalyzed by indium complexes. In the first method, a series of para-functionalized phenoxy-bridged dinuclear indium complexes [(NNO)InCl]2(μ-Cl)(μ-OPhR) (R = OMe (1), Me (2), H (3), Br (4), NO2 (5)) were synthesized and fully characterized. The solution and solid state structures of these complexes reflect the electronic differences between these initiators. The polymerization rates correlate with the electron donating ability of the phenoxy initiators: the para-nitro substituted complex 5 is essentially inactive...
May 10, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28481653/accuracy-of-nasal-nitric-oxide-measurement-as-a-diagnostic-test-for-primary-ciliary-dyskinesia-a-systematic-review-and-meta-analysis
#20
Adam J Shapiro, Maureen Josephson, Margaret Rosenfeld, Ozge Yilmaz, Stephanie D Davis, Deepika Polineni, Elena Guadagno, Margaret W Leigh, Valery Lavergne
RATIONALE: Primary ciliary dyskinesia (PCD) is a rare disorder causing chronic otosinopulmonary disease, generally diagnosed through evaluation of respiratory ciliary ultrastructure and/or genetic testing. Nasal nitric oxide (nNO) measurement is used as a PCD screening test because patients with PCD have low nNO levels, but its value as a diagnostic test remains unknown. OBJECTIVES: To perform a systematic review to assess the utility of nNO measurement (index test) as a diagnostic tool compared with the reference standard of electron microscopy (EM) evaluation of ciliary defects and/or detection of biallelic mutations in PCD genes...
July 2017: Annals of the American Thoracic Society
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