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Nasal nitric oxide

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https://www.readbyqxmd.com/read/28284536/specificity-and-reproducibility-of-nasal-biomarkers-in-patients-with-allergic-rhinitis-after-allergen-challenge-chamber-exposure
#1
Philipp Badorrek, Meike Müller, Wolfgang Koch, Jens M Hohlfeld, Norbert Krug
BACKGROUND: Allergic rhinitis is an inflammatory disease that causes cellular influx and mediator release in the nose. These inflammatory changes might be used as nasal biomarkers to assess the efficacy of novel anti-allergic treatments. OBJECTIVE: To assess the specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after grass pollen exposure in an allergen challenge chamber. METHODS: In a monocenter pilot study, 15 patients with allergic rhinitis and 19 healthy individuals underwent two 4-hour Dactylis glomerate pollen challenges in the challenge chamber with an interval of 21 days...
March 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28275474/effects-of-leukotriene-d4-nasal-challenge-on-bronchial-responsiveness-and-inflammation-in-asthmatic-patients-with-allergic-rhinitis
#2
Zheng Zhu, Yanqing Xie, Weijie Guan, Yi Gao, Rongquan Huang, Shu Xia, Wenhua Jian, Zhiyu Liang, Jinping Zheng
BACKGROUND: In asthmatic patients with allergic rhinitis (AR), increased cysteinyl leukotrienes (CysLTs) production in the secretion of nasal mucosa has been associated with greater bronchial hyperresponsiveness (BHR) after nasal allergen challenge. However, the role of CysLTs in eliciting BHR after nasal allergen challenge has not been evaluated. The aim of this study is to evaluate the effect of LTD4 nasal challenge on BHR and inflammation in asthmatic patients with AR. METHODS: In this self-controlled study, fifteen eligible consecutively recruited subjects underwent methacholine (Mch) bronchial provocation test before and 30 minutes after LTD4 nasal provocation test...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28248547/serum-periostin-as-a-biomarker-for-comorbid-chronic-rhinosinusitis-in-patients-with-asthma
#3
Takamitsu Asano, Yoshihiro Kanemitsu, Masaya Takemura, Makoto Yokota, Kensuke Fukumitsu, Norihisa Takeda, Hiroya Ichikawa, Takehiro Uemura, Osamu Takakuwa, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Yumi Maki, Junya Ono, Shoichiro Ohta, Yoshihisa Nakamura, Kenji Izuhara, Motohiko Suzuki, Akio Niimi
RATIONALE: Periostin is a matricellular protein that is involved in the pathophysiology of allergic rhinitis, chronic rhinosinusitis, and asthma. Associations of serum periostin with systemic and airway eosinophilic inflammation and comorbid chronic rhinosinusitis in patients with asthma have been demonstrated. Although serum periostin is positioned as a marker of helper T cell 2 (Th2) immune responses, its implication regarding the presence of comorbid upper airway diseases in patients with asthma remains unclear...
March 1, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28231472/effects-of-nasal-instillation-of-a-nitric-oxide-releasing-solution-or-parenteral-administration-of-tilmicosin-on-the-nasopharyngeal-microbiota-of-beef-feedlot-cattle-at-high-risk-of-developing-respiratory-tract-disease
#4
E Timsit, M Workentine, T Crepieux, C Miller, G Regev-Shoshani, A Schaefer, T Alexander
Nitric oxide has bactericidal and virucidal properties. Nasal instillation of a nitric oxide releasing solution (NORS) on arrival at the feedlot was recently reported as inferior to a parenteral injection of tilmicosin (macrolide antibiotic) for control of bovine respiratory disease (BRD) in cattle at high-risk of developing BRD. We hypothesized that this inferiority was due to differences between treatments with regards to their effects on the nasopharyngeal microbiota. The objective was to compare nasal instillation of NORS versus parenteral administration of tilmicosin regarding their effects on the nasopharyngeal microbiota of feedlot cattle at high-risk of developing BRD...
February 9, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28220034/exhaled-and-nasal-nitric-oxide-in-relation-to-lung-function-blood-cell-counts-and-disease-characteristics-in-cystic-fibrosis
#5
Christina Krantz, Christer Janson, Annika Hollsing, Kjell Alving, Andrei Malinovschi
BACKGROUND: Patients with cystic fibrosis (CF) have similar or lower exhaled nitric oxide (FeNO) and lower nasal nitric oxide (nNO) levels than controls. There are divergent results on alveolar NO (CalvNO) concentrations in relation to CF. There are inconsistent results on correlation between different nitric oxide parameters and lung function and inflammation in CF. AIM: To compare FeNO, CalvNO and nNO levels between subjects with CF, asthma and healthy controls and to study whether these parameters are related to lung function, blood cell counts or clinical characteristics in CF patients...
March 20, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28219166/-the-value-of-sinonasal-ct-scan-in-diagnosing-of-eosinophilic-chronic-rhinosinusitis-with-nasal-polyps
#6
Y F Meng, H F Lou, C S Wang, L Zhang
Objective: To compare the value of sinonasal CT scan with other clinical parameters in the pre-diagnosis of eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP). Methods: From January to May of 2016, One hundred and fifty consecutive CRSwNP patients (90 eCRSwNP and 60 non-eosinophilic CRSwNP) undergoing endoscopic functional sinus surgery in Beijing Tongren Hospital were recruited in this study. Preoperative CT scan, skin prick test (SPT) and oral fractional exhaled nitric oxide (FeNO) measurements were performed in each patient and full blood count with differential analysis was performed within 1 week before surgery...
February 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28199369/nasal-nitric-oxide-in-unilateral-sinus-disease
#7
Chia-Hsiang Fu, Hsiao-Jung Tseng, Chi-Che Huang, Po-Hung Chang, Yi-Wei Chen, Ta-Jen Lee
Unilateral sinus disease (USD) can sometimes be difficult to accurately diagnose before surgery. The application of nasal nitric oxide (nNO) for USD diagnosis and its surgical outcome in USD has not been reported in the literature. We prospectively enrolled sixty-six USD patients who underwent endoscopic sinus surgery for fungal rhinosinusitis (n = 19), chronic rhinosinusitis (CRS) without nasal polyps (n = 13), CRS with nasal polyps (n = 12) and sinonasal mass lesions (n = 22). nNO levels were measured preoperatively and at three and six months postoperatively...
2017: PloS One
https://www.readbyqxmd.com/read/28160867/fargesin-exerts-anti-inflammatory-effects-in-thp-1-monocytes-by-suppressing-pkc-dependent-ap-1-and-nf-%C3%A4-b-signaling
#8
Thu-Huyen Pham, Man-Sub Kim, Minh-Quan Le, Yong-Seok Song, Yesol Bak, Hyung-Won Ryu, Sei-Ryang Oh, Do-Young Yoon
BACKGROUND: Fargesin is a lignan from Magnolia fargesii, an oriental medicine used in the treatment of nasal congestion and sinusitis. The anti-inflammatory properties of this compound have not been fully elucidated yet. PURPOSE: This study focused on assessing the anti-inflammatory effects of fargesin on phorbal ester (PMA)-stimulated THP-1 human monocytes, and the molecular mechanisms underlying them. METHODS: Cell viability was evaluated by MTS assay...
January 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28137494/characteristics-associated-with-clinical-severity-and-inflammatory-phenotype-of-naturally-occurring-virus-induced-exacerbations-of-asthma-in-adults
#9
Asger Bjerregaard, Ingrid A Laing, Nadia Poulsen, Vibeke Backer, Asger Sverrild, Markus Fally, Siew-Kim Khoo, Lucy Barrett, Svetlana Baltic, Philip J Thompson, Glenys Chidlow, Chisha Sikazwe, David W Smith, Yury A Bochkov, Peter Le Souëf, Celeste Porsbjerg
BACKGROUND: In experimental studies viral infections have been shown to induce type 2 inflammation in asthmatics, but whether this is a feature of naturally occurring virus-induced asthma exacerbations is unknown. Thymic stromal lymphopoietin (TSLP) released from the airway epithelium in response to damage, has been suggested as a link between viral infection and type 2 inflammation, but the role of TSLP in asthma exacerbations is unknown. OBJECTIVE: To assess whether type 2 inflammation, as measured by sputum eosinophils and fractional exhaled nitric oxide (FeNO), is a feature of naturally occurring virus-induced exacerbations of asthma and whether TSLP is associated with this type 2 inflammation...
February 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28126433/two-inflammatory-phenotypes-of-nasal-polyps-and-comorbid-asthma
#10
Dawei Wu, Lun Li, Min Zhang, Jianting Wang, Yongxiang Wei
BACKGROUND: Nasal polyps and comorbid asthma (NPCA) is a common united airway disease. However, the inflammatory phenotyes of NPCA are not clear. OBJECTIVE: To identify inflammatory phenotypes of NPCA. METHODS: A total of 106 patients diagnosed with NPCA were recruited from rhinologic clinics. A combined method of biopsies from nasal polyps and fractional exhaled nitric oxide (FeNO) was used to explore inflammatory phenotyes of NPCA. Patients were evaluated with respect to clinical, functional, and inflammatory parameters...
March 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28096286/diagnosis-of-primary-ciliary-dyskinesia-potential-options-for-resource-limited-countries
#11
REVIEW
Nisreen Rumman, Claire Jackson, Samuel Collins, Patricia Goggin, Janice Coles, Jane S Lucas
Primary ciliary dyskinesia is a genetic disease of ciliary function leading to chronic upper and lower respiratory tract symptoms. The diagnosis is frequently overlooked because the symptoms are nonspecific and the knowledge about the disease in the primary care setting is poor. Additionally, none of the available tests is accurate enough to be used in isolation. These tests are expensive, and need sophisticated equipment and expertise to analyse and interpret results; diagnosis is therefore only available at highly specialised centres...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28051241/effects-of-omalizumab-therapy-on-allergic-rhinitis-a-pilot-study
#12
S Masieri, C Cavaliere, E Begvarfaj, D Rosati, A Minni
OBJECTIVE: The use of omalizumab, a humanized monoclonal antibody able to binding Ig-E, is currently authorized only for treatment of severe bronchial asthma. The use of omalizumab in other Ig-E related diseases is off-label, although some studies have provided promising results about it. The aim of this study was to evaluate if therapy with omalizumab in patients affected by asthma and allergic rhinitis has an impact also on allergic rhinitis-related symptoms. PATIENTS AND METHODS: A longitudinal study was conducted on 11 patients affected by severe asthma and a periodic allergic rhinitis...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28035225/specificity-and-sensitivity-assessment-of-selected-nasal-provocation-testing-techniques
#13
Edyta Krzych-Fałta, Konrad Furmańczyk, Bolesław Samoliński
INTRODUCTION: Nasal provocation testing involves an allergen-specific local reaction of the nasal mucosa to the administered allergen. AIM: To determine the most objective nasal occlusion assessment technique that could be used in nasal provocation testing. MATERIAL AND METHODS: A total of 60 subjects, including 30 patients diagnosed with allergy to common environmental allergens and 30 healthy subjects were enrolled into the study. The method used in the study was a nasal provocation test with an allergen, with a standard dose of a control solution and an allergen (5,000 SBU/ml) administered using a calibrated atomizer into both nostrils at room temperature...
December 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28029746/respiratory-manifestations-in-38-patients-with-alstr%C3%A3-m-syndrome
#14
Caroline Boerwinkle, Jan D Marshall, Joy Bryant, William A Gahl, Kenneth N Olivier, Meral Gunay-Aygun
OBJECTIVES: Alström syndrome (AS) is a rare, multi-system condition characterized by retinal degeneration, sensorineural hearing loss, obesity, insulin-resistant diabetes, hypertriglyceridemia, cardiomyopathy, hepatorenal disease, and recurrent respiratory infections. It belongs to a group of genetic disorders known as primary ciliopathies, which includes autosomal dominant and recessive polycystic kidney diseases, as well as Joubert and Bardet-Biedl syndromes. Prior studies have suggested phenotypic overlap between primary ciliopathies affecting the non-motile, sensory cilia, and primary ciliary dyskinesia (PCD), a motile ciliopathy characterized by respiratory tract disease...
December 28, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27935903/prevalence-of-primary-ciliary-dyskinesia-in-consecutive-referrals-of-suspect-cases-and-the-transmission-electron-microscopy-detection-rate-a-systematic-review-and-meta-analysis
#15
Panayiotis Kouis, Panayiotis K Yiallouros, Nicos Middleton, John S Evans, Kyriacos Kyriacou, Stefania I Papatheodorou
BackgroundDiagnostic testing for Primary Ciliary Dyskinesia (PCD) usually includes Transmission Electron Microscopy (TEM), nasal Nitric Oxide, High Speed Video Microscopy and genetics. Diagnostic performance of each test should be assessed towards the development of PCD diagnostic algorithms. We systematically reviewed the literature and quantified PCD prevalence among referrals and TEM detection rate in confirmed PCD patients.MethodsMajor electronic databases were searched until December 2015 using appropriate terms...
December 9, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27930477/respiratory-and-ocular-symptoms-among-employees-at-swedish-indoor-swimming-pools
#16
Håkan Löfstedt, Jessica Westerlund, Pål Graff, Ing-Liss Bryngelsson, Göte Mölleby, Anna-Carin Olin, Kåre Eriksson, Håkan Westberg
BACKGROUND: This study investigated trichloramine exposure and prevalence of respiratory and ocular symptoms among Swedish indoor swimming pool workers. METHODS: Questionnaires were distributed to pool workers and referents. Lung function and fraction of exhaled nitric oxide (FeNO) were measured before and after work. Exposure to trichloramine and trihalomethanes was measured over work shifts. RESULTS: The mean personal trichloramine exposure was 36 μg/m...
December 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27892921/an-essential-role-for-bacterial-nitric-oxide-synthase-in-staphylococcus-aureus-electron-transfer-and-colonization
#17
Traci L Kinkel, Smirla Ramos-Montañez, Jasmine M Pando, Daniel V Tadeo, Erin N Strom, Stephen J Libby, Ferric C Fang
Nitric oxide (NO(•)) is a ubiquitous molecular mediator in biology. Many signalling actions of NO(•) generated by mammalian NO(•) synthase (NOS) result from targeting of the haem moiety of soluble guanylate cyclase. Some pathogenic and environmental bacteria also produce a NOS that is evolutionary related to the mammalian enzymes, but a bacterial haem-containing receptor for endogenous enzymatically generated NO(•) has not been identified previously. Here, we show that NOS of the human pathogen Staphylococcus aureus, in concert with an NO(•)-metabolizing flavohaemoprotein, regulates electron transfer by targeting haem-containing cytochrome oxidases under microaerobic conditions to maintain membrane bioenergetics...
November 28, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27884476/systemic-immunization-with-rpotd-reduces-streptococcus-pneumoniae-nasopharyngeal-colonization-in-mice
#18
T R Converso, C Goulart, D Rodriguez, M Darrieux, L C C Leite
Streptococcus pneumoniae (pneumococcus) is a human pathogen that can cause otitis media, pneumonia and, in severe cases, meningitis and bacteremia. The pneumococcus expresses PotD, a protein belonging to the polyamines transporter complex called PotABCD. PotD is a membrane-associated protein that binds polyamines and has been shown to be important for virulence. In this work we demonstrate that subcutaneous immunization with rPotD reduces the bacterial load in the nasal tissue of mice, following intranasal challenge with a type 6B pneumococcus...
January 3, 2017: Vaccine
https://www.readbyqxmd.com/read/27852361/-lower-airway-abnormalities-in-patients-with-allergic-rhinitis
#19
J F Ji, Q P Wang, Y Zhang, Z Y Wang, Y Q Xie, W J Guan, K M Wu, L Xu, W Chen, F Xue, M J Jiang, T Y Wang, N S Zhong
Objective: To investigate the characteristics of lower airway abnormalities in allergic rhinitis(AR) patients without asthma. Methods: Between June 2008 and December 2012, 377 consecutive AR patients and 264 healthy subjects were recruited. All subjects underwent meticulous history taking, nasal examination, allergen skin prick test, blood routine test, serum total immunoglobin E assay, induced sputum cell count and differentials, measurement of fractional exhaled nitric oxide (FeNO) and bronchial challenge test...
November 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27837378/nasal-nitric-oxide-improved-by-continuous-positive-airway-pressure-therapy-for-upper-airway-inflammation-in-obstructive-sleep-apnea
#20
Satoshi Hamada, Shuji Tatsumi, Yoshiki Kobayashi, Hirotaka Yasuba
PURPOSE: In this report, we examined the association between obstructive sleep apnea (OSA) and upper and lower airway inflammation based on nitric oxide (NO) measurements. METHODS: Study subjects included 51 consecutive participants. Sleep-disordered breathing was evaluated by a type 3 portable monitor and quantified by respiratory disturbance index (RDI). Airway inflammation was noninvasively analyzed by the measurement of nasally and orally exhaled NO; nasal value was presented as nasally exhaled NO minus orally exhaled NO...
November 12, 2016: Sleep & Breathing, Schlaf & Atmung
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