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Nasal nitric oxide

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https://www.readbyqxmd.com/read/28096286/diagnosis-of-primary-ciliary-dyskinesia-potential-options-for-resource-limited-countries
#1
REVIEW
Nisreen Rumman, Claire Jackson, Samuel Collins, Patricia Goggin, Janice Coles, Jane S Lucas
Primary ciliary dyskinesia is a genetic disease of ciliary function leading to chronic upper and lower respiratory tract symptoms. The diagnosis is frequently overlooked because the symptoms are nonspecific and the knowledge about the disease in the primary care setting is poor. Additionally, none of the available tests is accurate enough to be used in isolation. These tests are expensive, and need sophisticated equipment and expertise to analyse and interpret results; diagnosis is therefore only available at highly specialised centres...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28051241/effects-of-omalizumab-therapy-on-allergic-rhinitis-a-pilot-study
#2
S Masieri, C Cavaliere, E Begvarfaj, D Rosati, A Minni
OBJECTIVE: The use of omalizumab, a humanized monoclonal antibody able to binding Ig-E, is currently authorized only for treatment of severe bronchial asthma. The use of omalizumab in other Ig-E related diseases is off-label, although some studies have provided promising results about it. The aim of this study was to evaluate if therapy with omalizumab in patients affected by asthma and allergic rhinitis has an impact also on allergic rhinitis-related symptoms. PATIENTS AND METHODS: A longitudinal study was conducted on 11 patients affected by severe asthma and a periodic allergic rhinitis...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28035225/specificity-and-sensitivity-assessment-of-selected-nasal-provocation-testing-techniques
#3
Edyta Krzych-Fałta, Konrad Furmańczyk, Bolesław Samoliński
INTRODUCTION: Nasal provocation testing involves an allergen-specific local reaction of the nasal mucosa to the administered allergen. AIM: To determine the most objective nasal occlusion assessment technique that could be used in nasal provocation testing. MATERIAL AND METHODS: A total of 60 subjects, including 30 patients diagnosed with allergy to common environmental allergens and 30 healthy subjects were enrolled into the study. The method used in the study was a nasal provocation test with an allergen, with a standard dose of a control solution and an allergen (5,000 SBU/ml) administered using a calibrated atomizer into both nostrils at room temperature...
December 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28029746/respiratory-manifestations-in-38-patients-with-alstr%C3%A3-m-syndrome
#4
Caroline Boerwinkle, Jan D Marshall, Joy Bryant, William A Gahl, Kenneth N Olivier, Meral Gunay-Aygun
OBJECTIVES: Alström syndrome (AS) is a rare, multi-system condition characterized by retinal degeneration, sensorineural hearing loss, obesity, insulin-resistant diabetes, hypertriglyceridemia, cardiomyopathy, hepatorenal disease, and recurrent respiratory infections. It belongs to a group of genetic disorders known as primary ciliopathies, which includes autosomal dominant and recessive polycystic kidney diseases, as well as Joubert and Bardet-Biedl syndromes. Prior studies have suggested phenotypic overlap between primary ciliopathies affecting the non-motile, sensory cilia, and primary ciliary dyskinesia (PCD), a motile ciliopathy characterized by respiratory tract disease...
December 28, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27935903/prevalence-of-primary-ciliary-dyskinesia-in-consecutive-referrals-of-suspect-cases-and-the-transmission-electron-microscopy-detection-rate-a-systematic-review-and-meta-analysis
#5
Panayiotis Kouis, Panayiotis K Yiallouros, Nicos Middleton, John S Evans, Kyriacos Kyriacou, Stefania I Papatheodorou
BackgroundDiagnostic testing for Primary Ciliary Dyskinesia (PCD) usually includes Transmission Electron Microscopy (TEM), nasal Nitric Oxide, High Speed Video Microscopy and genetics. Diagnostic performance of each test should be assessed towards the development of PCD diagnostic algorithms. We systematically reviewed the literature and quantified PCD prevalence among referrals and TEM detection rate in confirmed PCD patients.MethodsMajor electronic databases were searched until December 2015 using appropriate terms...
December 9, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27930477/respiratory-and-ocular-symptoms-among-employees-at-swedish-indoor-swimming-pools
#6
Håkan Löfstedt, Jessica Westerlund, Pål Graff, Ing-Liss Bryngelsson, Göte Mölleby, Anna-Carin Olin, Kåre Eriksson, Håkan Westberg
BACKGROUND: This study investigated trichloramine exposure and prevalence of respiratory and ocular symptoms among Swedish indoor swimming pool workers. METHODS: Questionnaires were distributed to pool workers and referents. Lung function and fraction of exhaled nitric oxide (FeNO) were measured before and after work. Exposure to trichloramine and trihalomethanes was measured over work shifts. RESULTS: The mean personal trichloramine exposure was 36 μg/m...
December 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27892921/an-essential-role-for-bacterial-nitric-oxide-synthase-in-staphylococcus-aureus-electron-transfer-and-colonization
#7
Traci L Kinkel, Smirla Ramos-Montañez, Jasmine M Pando, Daniel V Tadeo, Erin N Strom, Stephen J Libby, Ferric C Fang
Nitric oxide (NO(•)) is a ubiquitous molecular mediator in biology. Many signalling actions of NO(•) generated by mammalian NO(•) synthase (NOS) result from targeting of the haem moiety of soluble guanylate cyclase. Some pathogenic and environmental bacteria also produce a NOS that is evolutionary related to the mammalian enzymes, but a bacterial haem-containing receptor for endogenous enzymatically generated NO(•) has not been identified previously. Here, we show that NOS of the human pathogen Staphylococcus aureus, in concert with an NO(•)-metabolizing flavohaemoprotein, regulates electron transfer by targeting haem-containing cytochrome oxidases under microaerobic conditions to maintain membrane bioenergetics...
November 28, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27884476/systemic-immunization-with-rpotd-reduces-streptococcus-pneumoniae-nasopharyngeal-colonization-in-mice
#8
T R Converso, C Goulart, D Rodriguez, M Darrieux, L C C Leite
Streptococcus pneumoniae (pneumococcus) is a human pathogen that can cause otitis media, pneumonia and, in severe cases, meningitis and bacteremia. The pneumococcus expresses PotD, a protein belonging to the polyamines transporter complex called PotABCD. PotD is a membrane-associated protein that binds polyamines and has been shown to be important for virulence. In this work we demonstrate that subcutaneous immunization with rPotD reduces the bacterial load in the nasal tissue of mice, following intranasal challenge with a type 6B pneumococcus...
January 3, 2017: Vaccine
https://www.readbyqxmd.com/read/27852361/-lower-airway-abnormalities-in-patients-with-allergic-rhinitis
#9
J F Ji, Q P Wang, Y Zhang, Z Y Wang, Y Q Xie, W J Guan, K M Wu, L Xu, W Chen, F Xue, M J Jiang, T Y Wang, N S Zhong
Objective: To investigate the characteristics of lower airway abnormalities in allergic rhinitis(AR) patients without asthma. Methods: Between June 2008 and December 2012, 377 consecutive AR patients and 264 healthy subjects were recruited. All subjects underwent meticulous history taking, nasal examination, allergen skin prick test, blood routine test, serum total immunoglobin E assay, induced sputum cell count and differentials, measurement of fractional exhaled nitric oxide (FeNO) and bronchial challenge test...
November 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27837378/nasal-nitric-oxide-improved-by-continuous-positive-airway-pressure-therapy-for-upper-airway-inflammation-in-obstructive-sleep-apnea
#10
Satoshi Hamada, Shuji Tatsumi, Yoshiki Kobayashi, Hirotaka Yasuba
PURPOSE: In this report, we examined the association between obstructive sleep apnea (OSA) and upper and lower airway inflammation based on nitric oxide (NO) measurements. METHODS: Study subjects included 51 consecutive participants. Sleep-disordered breathing was evaluated by a type 3 portable monitor and quantified by respiratory disturbance index (RDI). Airway inflammation was noninvasively analyzed by the measurement of nasally and orally exhaled NO; nasal value was presented as nasally exhaled NO minus orally exhaled NO...
November 12, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27836958/european-respiratory-society-guidelines-for-the-diagnosis-of-primary-ciliary-dyskinesia
#11
Jane S Lucas, Angelo Barbato, Samuel A Collins, Myrofora Goutaki, Laura Behan, Daan Caudri, Sharon Dell, Ernst Eber, Estelle Escudier, Robert A Hirst, Claire Hogg, Mark Jorissen, Philipp Latzin, Marie Legendre, Margaret W Leigh, Fabio Midulla, Kim G Nielsen, Heymut Omran, Jean-Francois Papon, Petr Pohunek, Beatrice Redfern, David Rigau, Bernhard Rindlisbacher, Francesca Santamaria, Amelia Shoemark, Deborah Snijders, Thomy Tonia, Andrea Titieni, Woolf T Walker, Claudius Werner, Andrew Bush, Claudia E Kuehni
The diagnosis of primary ciliary dyskinesia is often confirmed with standard, albeit complex and expensive, tests. In many cases, however, the diagnosis remains difficult despite the array of sophisticated diagnostic tests. There is no "gold standard" reference test. Hence, a Task Force supported by the European Respiratory Society has developed this guideline to provide evidence-based recommendations on diagnostic testing, especially in light of new developments in such tests, and the need for robust diagnoses of patients who might enter randomised controlled trials of treatments...
November 11, 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27823578/measuring-nasal-nitric-oxide-in-allergic-rhinitis-patients
#12
V S Nesic, V Z Djordjevic, V Tomic-Spiric, Z R Dudvarski, I A Soldatovic, N A Arsovic
OBJECTIVE: This study aimed to compare two sampling methods for nasal nitric oxide in healthy individuals and allergic rhinitis patients, and to examine the within-subject reliability of nasal nitric oxide measurement. METHODS: The study included 23 allergic rhinitis patients without concomitant asthma and 10 healthy individuals. For all participants, nitric oxide levels were measured non-invasively from the lungs through the mouth (i.e. the oral fractional exhaled nitric oxide) and the nose...
November 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27792747/nasal-airflow-measured-by-rhinomanometry-correlates-with-feno-in-children-with-asthma
#13
I-Chen Chen, Yu-Tsai Lin, Jong-Hau Hsu, Yi-Ching Liu, Jiunn-Ren Wu, Zen-Kong Dai
BACKGROUND: Rhinitis and asthma share similar immunopathological features. Rhinomanometry is an important test used to assess nasal function and spirometry is an important tool used in asthmatic children. The degree to which the readouts of these tests are correlated has yet to be established. We sought to clarify the relationship between rhinomanometry measurements, fractional exhaled nitric oxide (FeNO), and spirometric measurements in asthmatic children. METHODS: Patients' inclusion criteria: age between 5 and 18 years, history of asthma with nasal symptoms, and no anatomical deformities...
2016: PloS One
https://www.readbyqxmd.com/read/27753120/longitudinal-analysis-of-inflammatory-biomarkers-during-acute-rhinosinusitis
#14
Timo J Autio, Timo Koskenkorva, Tuomo K Leino, Petri Koivunen, Olli-Pekka Alho
OBJECTIVE: To illuminate the pathophysiology of acute rhinosinusitis (ARS) with sequential monitoring of inflammatory biomarkers during an ARS episode and to clarify their diagnostic usability in bacterial ARS. STUDY DESIGN: Inception cohort study with 50 conscripts with ARS. METHODS: We collected peripheral blood high-sensitive C-reactive protein (hs-CRP), white blood cell (WBC), procalcitonin, and nasal nitric oxide (nNO) counts at 2 to 3 and 9 to 10 days of symptoms during an ARS episode...
October 18, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27711045/non-invasive-inhaled-nitric-oxide-in-the-treatment-of-hypoxemic-respiratory-failure-in-term-and-preterm-infants
#15
R Sahni, X Ameer, K Ohira-Kist, J-T Wung
OBJECTIVES: Inhaled nitric oxide (iNO) is effective in conjunction with tracheal intubation (TI) and mechanical ventilation (MV) for treating arterial pulmonary hypertension and hypoxemic respiratory failure (HRF) in near-term and term newborns. Non-invasive respiratory support with nasal continuous positive airway pressure (CPAP) is increasingly used to avoid morbidity associated with TI and MV, yet the effectiveness of iNO delivery via nasal CPAP remains unknown. To evaluate the effectiveness of iNO delivered via the bubble nasal CPAP system in term and preterm newborns with HRF...
January 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27707660/determinants-of-incomplete-asthma-control-in-patients-with-allergic-rhinitis-and-asthma
#16
Asako Oka, Tsunahiko Hirano, Yoshikazu Yamaji, Kosuke Ito, Keiji Oishi, Nobutaka Edakuni, Reo Kawano, Kazuto Matsunaga
BACKGROUND: Characterizing associations between the upper and lower airways is important for asthma management. OBJECTIVES: This study aimed to assess the determinants of incomplete asthma control in patients with allergic rhinitis (AR) and asthma. METHODS: Multiple factors including age, sex, atopy, smoking history, medication use, Asthma Control Questionnaire (ACQ) score, FEV1, fraction of exhaled nitric oxide (Feno), and rhinitis questionnaire score were examined...
January 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27696764/effects-of-leukotriene-d4-and-histamine-nasal-challenge-on-airway-responsiveness-and-inflammation-in-persistent-allergic-rhinitis-patients
#17
Zheng Zhu, Yanqing Xie, Weijie Guan, Yi Gao, Shu Xia, Rongquan Huang, Nanshan Zhong, Jinping Zheng
Background Both histamine and leukotrienes are implicated in the pathogenesis of allergic rhinitis (AR), although the pattern and severity of the nasal response to these two potent inflammatory mediators may differ, which has not been adequately studied in patients with persistent AR. Objective We sought to compare the differential effects of nasal challenge with leukotriene D4 (LTD4 ) and histamine on the airway response and inflammation in patients with AR. Methods An open-label, crossover study was performed in 25 persistent AR patients (AR group) and 16 healthy subjects (control group)...
October 3, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27692400/the-role-of-nasal-fractional-exhaled-nitric-oxide-as-an-objective-parameter-independent-of-nasal-airflow-resistance-in-the-diagnosis-of-allergic-rhinitis
#18
Sachio Takeno, Yutaka Okabayashi, Takashi Kohno, Kouhei Yumii, Katsuhiro Hirakawa
OBJECTIVE: Patients with allergic rhinitis (AR) show augmented activity of nitric oxide (NO) metabolism, similar to those in bronchial asthma (BA). We hypothesized that measurements of nasal fractional exhaled NO (FeNO) could be used as an objective marker to detect the presence of AR. Our objective was to clarify the influence of nasal airflow resistance (NAR) on nasal FeNO levels through an exhalation maneuver in symptomatic AR patients. We also examined the diagnostic test validity of the mean nasal FeNO level for disease discrimination by means of a receiver operating characteristic (ROC) curve analysis...
September 27, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27692146/primary-ciliary-dyskinesia-in-israel-prevalence-clinical-features-current-diagnosis-and-management-practices
#19
Revital Abitbul, Israel Amirav, Hannah Blau, Soliman Alkrinawi, Micha Aviram, David Shoseyov, Lea Bentur, Avraham Avital, Chaim Springer, Moran Lavie, Dario Prais, Husein Dabbah, Nael Elias, Arnon Elizur, Shmuel Goldberg, Avigdor Hevroni, Eitan Kerem, Anthony Luder, Yehudah Roth, Malena Cohen-Cymberknoh, Marta Ben Ami, Avigdor Mandelberg, Galit Livnat, Elie Picard, Joseph Rivlin, Moshe Rotschild, Ruth Soferman, Niki T Loges, Heike Olbrich, Claudius Werner, Alexander Wolter, Martina Herting, Julia Wallmeier, Johanna Raidt, Heymut Omran, Huda Mussaffi
BACKGROUND: Primary Ciliary Dyskinesia (PCD) is rare and its features in Israel have not been described. AIMS: to assess prevalence utilizing state-of-the-art diagnostic techniques, and describe clinical features, diagnostic and management practices in Israel. METHODS: A national multicenter study from 2012 to 2013 recruited patients diagnosed or suspected of having PCD. Diagnosis was verified using: nasal Nitric Oxide (nNO); High-speed Video Microscope Analysis (HVMA); Transmission Electron Microscopy (TEM) of cilia; Immuno-fluorescence staining (IF) for ciliary proteins, and genetic analysis...
October 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27680603/clinical-phenotype-and-current-diagnostic-criteria-for-primary-ciliary-dyskinesia
#20
Eleonora Dehlink, Claire Hogg, Siobhan B Carr, Andrew Bush
Primary ciliary dyskinesia (PCD) is a rare, mostly autosomal-recessive disorder of motile cilia, characterized by chronic lung disease, rhinosinusitis, hearing impairment, and subfertility. PCD is still often missed or diagnosed late since symptoms overlap with common respiratory complaints, but should be considered if one or more of the cardinal clues are present. Areas covered: We provide an overview on clinical presentations of PCD and clues for when to consider PCD, these include unexplained neonatal respiratory distress, persistent rhinitis from the first days of life, situs anomalies, or otorrhoea following tympanostomy tube insertion...
October 19, 2016: Expert Review of Respiratory Medicine
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