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https://www.readbyqxmd.com/read/28922261/the-effect-of-gluten-free-diet-on-clinical-symptoms-and-the-intestinal-mucosa-of-patients-with-potential-celiac-disease
#1
Roberta Mandile, Valentina Discepolo, Serena Scapaticci, Maria Rosaria Del Vecchio, Maria Antonia Maglio, Luigi Greco, Riccardo Troncone, Renata Auricchio
In this prospective study, we evaluated the effect of gluten free diet (GFD) in a cohort of 65 children with potential celiac disease (PCD). Patients received GFD for signs/symptoms (N = 47) or parents' choice (N = 18). Most frequent signs/symptoms were low Body Mass Index (BMI) (36%), recurrent abdominal pain (34%) and diarrhea (19%). Of the 35/47 patients followed-up on GFD, only 54% (19/35) showed a complete clinical response. In 9/65 patients an intestinal biopsy was also performed after at least one year of GFD...
September 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28922056/secondary-defects-detected-by-transmission-electron-microscopy-in-primary-ciliary-dyskinesia-diagnostics
#2
Mellisa Dixon, Amelia Shoemark
Primary ciliary dyskinesia (PCD) is predominantly an autosomal recessively inherited condition that affects ~1 in 15,000 people. Diagnosis of PCD can be complex and is ordinarily based on the results of multiple investigations. These investigations include nasal nitric oxide, high-speed video microscopy, genotyping, and electron microscopy analysis of ciliary ultrastructure. A diagnosis is ultimately confirmed by the presence of a hallmark defect identified by transmission electron microscopy or biallelic variants in a known PCD gene...
September 18, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28922052/applications-of-emerging-transmission-electron-microscopy-technology-in-pcd-research-and-diagnosis
#3
Amelia Shoemark
Primary Ciliary Dyskinesia (PCD) is a heterogeneous genetic condition characterized by dysfunction of motile cilia. Patients suffer from chronic infection and inflammation of the upper and lower respiratory tract. Diagnosis of PCD is confirmed by identification of a hallmark defect of ciliary ultrastructure or by identification of biallelic pathogenic mutations in a known PCD gene. Since the first description of PCD in 1976, assessment of ciliary ultrastructure by transmission electron microscopy (TEM) has been central to diagnosis and research...
September 18, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28915070/value-of-transmission-electron-microscopy-for-primary-ciliary-dyskinesia-diagnosis-in-the-era-of-molecular-medicine-genetic-defects-with-normal-and-non-diagnostic-ciliary-ultrastructure
#4
Adam J Shapiro, Margaret W Leigh
Primary ciliary dyskinesia (PCD) is a genetic disorder causing chronic oto-sino-pulmonary disease. No single diagnostic test will detect all PCD cases. Transmission electron microscopy (TEM) of respiratory cilia was previously considered the gold standard diagnostic test for PCD, but 30% of all PCD cases have either normal ciliary ultrastructure or subtle changes which are non-diagnostic. These cases are identified through alternate diagnostic tests, including nasal nitric oxide measurement, high-speed videomicroscopy analysis, immunofluorescent staining of axonemal proteins, and/or mutation analysis of various PCD causing genes...
September 15, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28905682/management-of-post-traumatic-phlegmasia-cerulea-dolens-via-right-to-left-femoral-vein-to-femoral-vein-bypass-palma-procedure
#5
Anahita Dua, Jennifer Heller, Cheong Lee
Phlegmasia cerulea dolens (PCD) is a rare condition resulting from venous occlusion that impairs arterial flow. We report a rare case of post-traumatic PCD after ligation of the iliac vein with successful treatment by right-to-left femoral vein to femoral vein bypass using left great saphenous vein (Palma procedure). The clinical presentation, diagnostic process, and approach to management along with a literature review on the operative management of PCD are presented in this case report.
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28894478/diagnosis-of-primary-ciliary-dyskinesia-summary-of-the-ers-task-force-report
#6
Claudia E Kuehni, Jane S Lucas
KEY POINTS: Primary ciliary dyskinesia (PCD) is a genetically and clinically heterogeneous disease characterised by abnormal motile ciliary function.There is no "gold standard" diagnostic test for PCD.The European Respiratory Society (ERS) Task Force Guidelines for diagnosing PCD recommend that patients should be referred for diagnostic testing if they have several of the following features: persistent wet cough; situs anomalies; congenital cardiac defects; persistent rhinitis; chronic middle ear disease with or without hearing loss; or a history, in term infants, of neonatal upper and lower respiratory symptoms or neonatal intensive care admission...
September 2017: Breathe
https://www.readbyqxmd.com/read/28891733/application-of-laboratory-and-digital-techniques-for-visual-enhancement-during-the-ultrastructural-assessment-of-cilia
#7
Josef A Schroeder
Routine diagnostic electron microscopy of primary ciliary dyskinesia (PCD) is based on the findings of ultrastructural defects of axonemal components. Assessment of the typical abnormalities can be enhanced by improving the sample preservation status using tannic acid (TA) as additive in the biopsy fixation or processing steps. Another option is the implementation of computer-assisted image analysis tools. Advancements in high-resolution 3D visualization of the axonemal structure have been noted, with great potential for the future diagnosis of inherited cilia disorders...
September 11, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28890436/primary-ciliary-dyskinesia-ciliated-airway%C3%A2-cells-show-increased-susceptibility-to-haemophilus-influenzae-biofilm-formation
#8
Woolf T Walker, Claire L Jackson, Raymond N Allan, Samuel A Collins, Michael J Kelso, Ardeshir Rineh, Nageshwar R Yepuri, Ben Nicholas, Laurie Lau, David Johnston, Peter Lackie, Saul N Faust, Jane S A Lucas, Luanne Hall-Stoodley
Non-typeable Haemophilus influenzae (NTHi) is the most common pathogen in primary ciliary dyskinesia (PCD) patients. We hypothesised that abnormal ciliary motility and low airway nitric oxide (NO) levels on airway epithelial cells from PCD patients might be permissive for NTHi colonisation and biofilm development.We used a primary epithelial cell co-culture model to investigate NTHi infection. Primary airway epithelial cells from PCD and non-PCD patients were differentiated to ciliation using an air-liquid interface culture and then co-cultured with NTHi...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28887464/rnaseq-revealed-the-important-gene-pathways-controlling-adaptive-mechanisms-under-waterlogged-stress-in-maize
#9
Kanika Arora, Kusuma Kumari Panda, Shikha Mittal, Mallana Gowdra Mallikarjuna, Atmakuri Ramakrishna Rao, Prasanta Kumar Dash, Nepolean Thirunavukkarasu
Waterlogging causes yield penalty in maize-growing countries of subtropical regions. Transcriptome analysis of the roots of a tolerant inbred HKI1105 using RNA sequencing revealed 21,364 differentially expressed genes (DEGs) under waterlogged stress condition. These 21,364 DEGs are known to regulate important pathways including energy-production, programmed cell death (PCD), aerenchyma formation, and ethylene responsiveness. High up-regulation of invertase (49-fold) and hexokinase (36-fold) in roots explained the ATP requirement in waterlogging condition...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28886228/the-serum-heavy-light-chain-immunoassay-a-valuable-tool-for-sensitive-paraprotein-assessment-risk-and-disease-monitoring-in-monoclonal-gammopathies
#10
Christine Greil, Gabriele Ihorst, Felix Gaiser, Ulrich Salzer, Emanuel Bisse, Efstathios Kastritis, Heinz Ludwig, Ralph Wäsch, Monika Engelhardt
OBJECTIVE: The heavy/light chain (HLC)-immunoassay quantifies light chain types of each immunoglobulin class in patients with monoclonal gammopathies. METHODS: We assessed 147 consecutive patients with different forms and stages of plasma cell dyscrasias (PCD) who received standard tests (serum and urine protein electrophoresis [SPEP, UPEP], immunofixation [IFE], serum free light chain [SFLC]) and HLC-immunoassay. Patients with multiple myeloma (MM, n=102), smoldering MM (SMM, n=5), monoclonal gammopathy of undetermined significance (MGUS, n=28) and waldenström's macroglobulinemia (WM, n=12) were included...
September 8, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28877972/clinical-care-for-primary-ciliary-dyskinesia-current-challenges-and-future-directions
#11
REVIEW
Bruna Rubbo, Jane S Lucas
Primary ciliary dyskinesia (PCD) is a rare genetic disease that affects the motility of cilia, leading to impaired mucociliary clearance. It is estimated that the vast majority of patients with PCD have not been diagnosed as such, providing a major obstacle to delivering appropriate care. Challenges in diagnosing PCD include lack of disease-specific symptoms and absence of a single, "gold standard", diagnostic test. Management of patients is currently not based on high-level evidence because research findings are mostly derived from small observational studies with limited follow-up period...
September 30, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28871536/measurement-of-oxygen-status-in-arabidopsis-leaves-undergoing-the-hypersensitive-response-during-pseudomonas-infection
#12
Aprajita Kumari, Gail M Preston, Kapuganti Jagadis Gupta
When plants are infected with pathogens they defend themselves via various processes. Once such process is the development of the hypersensitive response (HR), a kind of programmed cell death (PCD), in which localized cell death takes place in order to prevent pathogen spread to other part of tissue. The Arabidopsis and Pseudomonas syringae system is one of the best known examples to study the HR. Here we used the VisiSens™ oxygen-imaging system to investigate oxygen distributions in Arabidopsis leaves infected with an avirulent strain of P...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28868250/the-relationship-between-uterine-artery-two-dimensional-color-doppler-measurement-and-pregnancy-outcome-a-prospective-observational-study
#13
Sudha Prasad, Ritu Goyal, Yogesh Kumar, Poonam Nayar, Supriya Hajela, Aswathy Kumaran, Rajesh Vairagi, Shalini Chauhan
BACKGROUND: The purpose of the study was to evaluate the role of uterine blood flow parameters measured by uterine artery two-dimensional (2D)-power color doppler (PCD) ultrasound in predicting fertility outcomes in women undergoing IVF-ET cycles. METHODS: In this prospective observational study, a total of 188 infertile women who underwent IVF-ET cycles were investigated. Uterine artery 2D-PD measurements were taken during early follicular phase and on day of trigger...
April 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/28866486/estimation-of-basis-line-integrals-in-a-spectral-distortion-modeled-photon-counting-detector-using-low-rank-approximation-based-x-ray-transmittance-modeling-k-edge-imaging-application
#14
Okkyun Lee, Steffen Kappler, Christoph Polster, Katsuyuki Taguchi
Photon counting detectors (PCD) provide multiple energy-dependent measurements for estimating basis lineintegrals. However, the measured spectrum is distorted from the spectral response effect (SRE) via charge sharing, K-fluorescence emission, etc. Thus, in order to avoid bias and artifacts in images, the SRE needs to be compensated. For this purpose, we recently developed a computationally efficient three-step algorithm for PCD-CT without contrast agents by approximating smooth x-ray transmittance using low-order polynomial bases...
August 29, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28859703/sinus-bacteriology-in-patients-with-cystic-fibrosis-or-primary-ciliary-dyskinesia-a-systematic-review
#15
Maria E Møller, Mikkel C Alanin, Christian Grønhøj, Kasper Aanæs, Niels Høiby, Christian von Buchwald
BACKGROUND: A correlation exists between the microbial flora of the upper and lower airways in patients with cystic fibrosis (CF) or with primary ciliary dyskinesia (PCD). The sinuses can function as a bacterial reservoir where gram-negative bacteria adapt to the airways and repeatedly are aspirated to and colonize the lungs according to the theory of the united (unified) airways. Whereas the pattern of bacterial flora in the lower airways has been extensively studied, the upper airways have drawn limited attention...
September 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28854737/restriction-endonuclease-triggered-bacterial-apoptosis-as-a-mechanism-for-long-time-survival
#16
Easa Nagamalleswari, Sandhya Rao, Kommireddy Vasu, Valakunja Nagaraja
Programmed cell death (PCD) under certain conditions is one of the features of bacterial altruism. Given the bacterial diversity and varied life style, different PCD mechanisms must be operational that remain largely unexplored. We describe restriction endonuclease (REase) mediated cell death by an apoptotic pathway, beneficial for isogenic bacterial communities. Cell death is pronounced in stationary phase and when the enzyme exhibits promiscuous DNA cleavage activity. We have elucidated the molecular mechanism of REase mediated cell killing and demonstrate that released nutrients from dying cells support the growth of the remaining cells in the population...
August 21, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28854230/heterologous-expression-of-anti-apoptotic-human-14-3-3%C3%AE-%C3%AE-enhances-iron-mediated-programmed-cell-death-in-yeast
#17
Rawan Eid, David R Zhou, Nagla T T Arab, Eric Boucher, Paul G Young, Craig A Mandato, Michael T Greenwood
The induction of Programmed Cell Death (PCD) requires the activation of complex responses involving the interplay of a variety of different cellular proteins, pathways, and processes. Uncovering the mechanisms regulating PCD requires an understanding of the different processes that both positively and negatively regulate cell death. Here we have examined the response of normal as well as PCD resistant yeast cells to different PCD inducing stresses. As expected cells expressing the pro-survival human 14-3-3β/α sequence show increased resistance to numerous stresses including copper and rapamycin...
2017: PloS One
https://www.readbyqxmd.com/read/28852767/european-society-of-paediatric-radiology-abdominal-imaging-task-force-recommendations-in-paediatric-uroradiology-part-ix-imaging-in-anorectal-and-cloacal-malformation-imaging-in-childhood-ovarian-torsion-and-efforts-in-standardising-paediatric-uroradiology
#18
REVIEW
Michael Riccabona, Maria-Luisa Lobo, Lil-Sofie Ording-Muller, A Thomas Augdal, E Fred Avni, Johan Blickman, Constanza Bruno, Beatrice Damasio, Kassa Darge, Akaterina Ntoulia, Frederica Papadopoulou, Pierre-Hugues Vivier
At the occasion of the European Society of Paediatric Radiology (ESPR) annual meeting 2015 in Graz, Austria, the newly termed ESPR abdominal (gastrointestinal and genitourinary) imaging task force set out to complete the suggestions for paediatric urogenital imaging and procedural recommendations. Some of the last missing topics were addressed and proposals on imaging of children with anorectal and cloacal malformations and suspected ovarian torsion were issued after intense discussions and a consensus finding process that considered all evidence...
September 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28851817/silencing-and-augmentation-of-iag-hormone-transcripts-in-adult-m-rosenbergii-males-affects-morphotype-transformation
#19
Himanshu Priyadarshi, Rekha Das, Annam Pavan-Kumar, Pathakota Gireesh-Babu, Hasan Javed, Sujit Kumar, Makesh Marappan, Somdutt, Gopal Krishna, Aparna Chaudhari
Morphotypic differentiation is the external manifestation of dominance hierarchy in Macrobrachium rosenbergii The intermediate morphotype orange claw (OC) male exhibits the highest growth rate and is subordinate in hierarchy to blue claw (BC) male while dominant on small male (SM). The present study was undertaken to examine the specific role of insulin-like androgenic gland (iag) hormone in morphotype differentiation of M. rosenbergii To achieve this, RNAi mediated knockdown as well as augmentation of iag transcripts were effected in ∼60g OC males using plasmid-based constructs pcD-IAG-lh and pcD-IAGorf, respectively...
August 29, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28851711/perturbing-phosphoinositide-homeostasis-oppositely-affects-vascular-differentiation-in-arabidopsis-thaliana-roots
#20
Bojan Gujas, Tiago M D Cruz, Elizabeth Kastanaki, Joop E M Vermeer, Teun Munnik, Antia Rodriguez-Villalon
The plant vascular network consists of specialized phloem and xylem elements that undergo two distinct morphogenetic developmental programs to become transport-functional units. While vacuolar rupture is a determinant step in protoxylem differentiation, protophloem elements never form a big central vacuole. Here we show that a genetic disturbance of phosphatidylinositol 4,5-bis-phosphate [PtdIns(4,5)P2] homeostasis rewires cell trafficking towards the vacuole in Arabidopsis thaliana roots. Consequently, an enhanced phosphoinositide-mediated vacuolar biogenesis correlate with premature programmed cell death (PCD) and secondary cell wall elaboration in xylem cells...
August 29, 2017: Development
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