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https://www.readbyqxmd.com/read/29773397/self-healable-tough-supramolecular-hydrogels-crosslinked-by-poly-cyclodextrin-through-host-guest-interaction
#1
Tingting Cai, Shuangjun Huo, Tao Wang, Weixiang Sun, Zhen Tong
A new supramolecular hydrogel with superior self-healing and shape memory properties was synthesized via in-situ copolymerization of the adamantane-containing monomer N-adamantylacrylamide (Ad-AAm) and monomer acrylic acid (AAc) in the polycyclodextrin (PCD) aqueous solution, where PCD served as the polyfunctional physical cross-linker. The PCD-Ad hydrogels showed strength of 40 kPa with breaking strain of 600%, but small tensile loading-unloading hysteresis and residual deformation benefited from the reversible crosslinking structure...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29772476/fate-of-nuclear-material-during-subsequent-steps-of-the-kinetin-induced-pcd-in-apical-parts-of-vicia-faba-ssp-minor-seedling-roots
#2
Andrzej Kaźmierczak, Kamila Soboska
In animals during apoptosis, the best examined type of programmed cell death (PCD), three main phases are distinguished: (i) specification (signaling), (ii) killing and (iii) execution one. It has bean postulated that plant PCD also involves three subsequent phases: (i) transmission of death signals to cells (signaling), (ii) initiation of killing processes and (iii) destruction of cells. One of the most important hallmarks of animal and plant PCD are those regarding nucleus, not thoroughly studied in plants so far...
April 30, 2018: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29767409/the-use-of-serum-free-light-chain-dimerization-patterns-assist-in-the-diagnosis-of-al-amyloidosis
#3
Moshe E Gatt, Batia Kaplan, Dean Yogev, Elana Slyusarevsky, Galina Pogrebijski, Sizilia Golderman, Olga Kukuy, Avi Livneh
The discrimination between benign and malignant forms of plasma cell dyscrasia (PCD) is often difficult. Free light chain monomer-dimer pattern analysis (FLC-MDPA) may assist in solving this dilemma and distinguish between AL amyloidosis and benign PCD. Serum samples of patients with AL amyloidosis and benign PCD were analysed in a blinded manner. Quantitative Western blotting was performed to estimate dimerization and clonality indices, and thereby determine the source of the tested samples, as derived either from benign or malignant PCD...
May 16, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29762621/ni-core-cuo-shell-fibers-produced-by-electrospinning-and-electroplating-as-efficient-photocathode-materials-for-solar-water-splitting
#4
Hong-Seok Jo, Min-Woo Kim, Bhavana Joshi, Edmund Samuel, Hyun Yoon, Mark T Swihart, Sam S Yoon
Charge recombination in CuO photocathodes inhibits efficient electron flow and limits the photo-electrochemical performance of these cathodes for solar water splitting. To circumvent this shortcoming, we introduce highly conductive Ni/CuO core-shell structured fibers. The photocurrent density (PCD) achieved with these core-shell fibers exceeded that of fibers without a Ni core by a factor of 2.6. The PCD enhancement arises from increased acceptor concentration and electron-hole recombination time, as measured by electrochemical impedance spectroscopy...
May 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/29760953/hyperglycemia-potentiates-a-shift-from-apoptosis-to-rip1-dependent-necroptosis
#5
William D McCaig, Payal S Patel, Sergey A Sosunov, Nicole L Shakerley, Tori A Smiraglia, Miranda M Craft, Katharine M Walker, Matthew A Deragon, Vadim S Ten, Timothy J LaRocca
Apoptosis and necroptosis are the primary modes of eukaryotic cell death, with apoptosis being non-inflammatory while necroptosis is highly inflammatory. We previously demonstrated that, once activated, necroptosis is enhanced by hyperglycemia in several cell types. Here, we determine if hyperglycemia affects apoptosis similarly. We show that hyperglycemia does not enhance extrinsic apoptosis but potentiates a shift to RIP1-dependent necroptosis. This is due to increased levels and activity of RIP1, RIP3, and MLKL, as well as decreased levels and activity of executioner caspases under hyperglycemic conditions following stimulation of apoptosis...
2018: Cell Death Discovery
https://www.readbyqxmd.com/read/29759924/resources-used-in-the-treatment-of-perianal-crohn-s-disease-and-the-results-in-a-real-life-cohort
#6
Cristina Rubín de Célix Vargas, Alicia Algaba, Iván Guerra, Ángel Serrano, Estíbaliz Pérez-Viejo, Carolina Aulló, Fernando Bermejo
OBJECTIVE: To study the multidisciplinary management of patients with Crohn's disease (CD) and perianal disease (perianal Crohn's disease, PCD), as well as to analyse a possible relationship between the recurrence of perianal symptoms, the type of fistula and the treatment used. PATIENTS AND METHODS: Descriptive, retrospective study of patients with PCD who were treated in the Inflammatory Bowel Disease Unit. Epidemiological, clinical, diagnostic and therapeutic variables were collected, as well as clinical outcome and response to treatment...
May 11, 2018: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29752808/prenatal-sonographic-description-of-fetuses-affected-by-pyruvate-dehydrogenase-or-pyruvate-carboxylase-deficiency
#7
Olivier Picone, Charles Egloff, Aurelia Eldin de Pecoulas, Charlotte Mechler, Audrey Boutron, Isabelle Simon, Agnes Guet, Jeanne Sibiude, Laurent Mandelbrot
INTRODUCTION: Pyruvate dehydrogenase deficiency (PDHD) and pyruvate carboxylase deficiency (PCD) are diseases with severe neonatal forms, and their low prevalence makes them difficult to diagnose during pregnancy. Our objective was to describe prenatal ultrasound features that may be suggestive of these diagnoses. METHODS: We analyzed 3 cases from our institution and reviewed 12 published cases of PDHD and 6 cases of PCD, recording all of the ultrasound signs, as well as magnetic resonance (MR) findings when available...
May 12, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29749309/the-application-of-natural-products-in-cancer-therapy-by-targeting-apoptosis-pathways
#8
Yan Wang, Jian Zhong, Jiaojiao Bai, Rongsheng Tonga, Feifei An, Pengcheng Jiao, Lin He, Daiwen Zeng, Enwu Long, Junfeng Yan, Jiying Yu, Lulu Cai
Apoptosis is one of the pathways of programmed cell death (PCD), which leads to pathognomic cellular changes different from cellular necrosis. It includes the death receptor pathway and the mitochondrial pathway, both of which involve many key proteins, including cytochrome c, Fas, the Bcl-2 family, caspases, survivin and p53. In apoptosis-related diseases, such as cancer, many proteins associated with apoptosis are abnormally expressed. The majority of anti-cancer agents promote apoptosis to induce cancer cell death...
May 11, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29740206/usefulness-of-three-dimensional-visualization-technology-in-minimally-invasive-treatment-for-infected-necrotizing-pancreatitis
#9
Peng-Fei Wang, Zhi-Wei Liu, Shou-Wang Cai, Jun-Jun Su, Lei He, Jian Feng, Xian-Lei Xin, Shi-Chun Lu
AIM: To explore the value of three-dimensional (3D) visualization technology in the minimally invasive treatment for infected necrotizing pancreatitis (INP). METHODS: Clinical data of 18 patients with INP, who were admitted to the PLA General Hospital in 2017, were retrospectively analyzed. Two-dimensional images of computed tomography were converted into 3D images based on 3D visualization technology. The size, number, shape and position of lesions and their relationship with major abdominal vasculature were well displayed...
May 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29737483/effects-of-long-term-fertilization-practices-on-heavy-metal-cadmium-accumulation-in-the-surface-soil-and-rice-plants-of-double-cropping-rice-system-in-southern-china
#10
Yilan Xu, Haiming Tang, Tangxing Liu, Yifeng Li, Xinjie Huang, Jun Pi
Fertilizer regime is playing an important role in heavy metal cadmium (Cd) accumulation in paddy soils and crop plant. It is necessary to assess the Cd accumulation in soils and rice (Oryza sativa L.) plants under long-term fertilization managements, and the results which help to assess the environmental and food risk in Southern China. However, the effects of different organic manure and chemical fertilizers on Cd accumulation in soils and rice plant remain unclear under intensively cultivated rice conditions...
May 8, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29736248/reactive-oxygen-species-and-nitric-oxide-induce-senescence-of-rudimentary-leaves-and-the-expression-profiles-of-the-related-genes-in-litchi-chinensis
#11
Haifang Yang, Hye-Ji Kim, Houbin Chen, Yong Lu, Xingyu Lu, Congcong Wang, Biyan Zhou
Litchi is one of the most important subtropical evergreen fruit trees in southern Asia. Previous studies indicated that high-temperature conditions encourage growth of rudimentary leaves in panicles and suppress flowering. We have demonstrated that methyl viologen dichloride hydrate (MV) and sodium nitroprusside (SNP) promoted flowering in litchi partially by inhibiting the growth of rudimentary leaves via reactive oxygen species (ROS) and nitric oxide (NO). In the present study, we examined the microstructure and ultrastructure, programmed cell death (PCD) ratio, nuclei morphology of the rudimentary leaves, and the expression of senescence-related genes after the treatment with ROS or NO...
2018: Horticulture Research
https://www.readbyqxmd.com/read/29733809/optical-coherence-tomography-angiography-in-optic-disc-swelling
#12
Masoud Aghsaei Fard, Jalil Jalili, Alireza Sahraiyan, Hassan Khojasteh, Marjane Hejazi, Robert Ritch, Prem S Subramanian
PURPOSE: To compare optical coherence tomography angiography (OCT-A) of peripapillary total vasculature and capillaries in patients with optic disc swelling. DESIGN: Cross-sectional study. METHODS: Twenty nine eyes with acute nonarteritic anterior ischemic optic neuropathy (NAION), 44 eyes with papilledema, 8 eyes with acute optic neuritis, and 48 eyes of normal subjects were imaged using OCT-A. Peripapillary total vasculature information was recorded using a commercial vessel density map...
May 4, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29729572/the-effects-of-organophosphorus-insecticides-and-heavy-metals-on-dna-damage-and-programmed-cell-death-in-two-plant-models
#13
Josefina Cortés-Eslava, Sandra Gómez-Arroyo, Maria C Risueño, Pilar S Testillano
The ubiquity of pollutants, such as agrochemicals and heavy metals, constitute a serious risk to human health. To evaluate the induction of DNA damage and programmed cell death (PCD), root cells of Allium cepa and Vicia faba were treated with two organophosphate insecticides (OI), fenthion and malathion, and with two heavy metal (HM) salts, nickel nitrate and potassium dichromate. An alkaline variant of the comet assay was performed to identify DNA breaks; the results showed comets in a dose-dependent manner, while higher concentrations induced clouds following exposure to OIs and HMs...
May 2, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29729068/mitochondrial-alternative-oxidase-dependent-autophagy-involved-in-ethylene-mediated-drought-tolerance-in-solanum-lycopersicum
#14
Tong Zhu, Lijuan Zou, Yan Li, Xiuhong Yao, Fei Xu, Xingguang Deng, Dawei Zhang, Honghui Lin
Mitochondrial alternative oxidase (AOX) is involved in a large number of plant physiological processes, such as growth, development and stress responses; however, the exact role of AOX in response to drought remains unclear. In our study, we provide solid evidences that the activated AOX capacity positively involved in ethylene-induced drought tolerance, in tomato (Solanum lycopersicum), accompanied by the changing level of hydrogen peroxide (H2 O2 ) and autophagy. In AOX1a-RNAi plants, the ethylene-induced drought tolerance was aggravated and associated with decreasing level of autophagy...
May 4, 2018: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29727693/mutations-in-c11orf70-cause-primary-ciliary-dyskinesia-with-randomization-of-left-right-body-asymmetry-due-to-defects-of-outer-and-inner-dynein-arms
#15
Inga M Höben, Rim Hjeij, Heike Olbrich, Gerard W Dougherty, Tabea Nöthe-Menchen, Isabella Aprea, Diana Frank, Petra Pennekamp, Bernd Dworniczak, Julia Wallmeier, Johanna Raidt, Kim G Nielsen, Maria C Philipsen, Francesca Santamaria, Laura Venditto, Israel Amirav, Huda Mussaffi, Freerk Prenzel, Kaman Wu, Zeineb Bakey, Miriam Schmidts, Niki T Loges, Heymut Omran
Primary ciliary dyskinesia (PCD) is characterized by chronic airway disease, male infertility, and randomization of the left/right body axis as a result of defects of motile cilia and sperm flagella. We identified loss-of-function mutations in the open-reading frame C11orf70 in PCD individuals from five distinct families. Transmission electron microscopy analyses and high-resolution immunofluorescence microscopy demonstrate that loss-of-function mutations in C11orf70 cause immotility of respiratory cilia and sperm flagella, respectively, as a result of the loss of axonemal outer (ODAs) and inner dynein arms (IDAs), indicating that C11orf70 is involved in cytoplasmic assembly of dynein arms...
May 3, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29727692/c11orf70-mutations-disrupting-the-intraflagellar-transport-dependent-assembly-of-multiple-axonemal-dyneins-cause-primary-ciliary-dyskinesia
#16
Mahmoud R Fassad, Amelia Shoemark, Pierrick le Borgne, France Koll, Mitali Patel, Mellisa Dixon, Jane Hayward, Charlotte Richardson, Emily Frost, Lucy Jenkins, Thomas Cullup, Eddie M K Chung, Michel Lemullois, Anne Aubusson-Fleury, Claire Hogg, David R Mitchell, Anne-Marie Tassin, Hannah M Mitchison
Primary ciliary dyskinesia (PCD) is a genetically and phenotypically heterogeneous disorder characterized by destructive respiratory disease and laterality abnormalities due to randomized left-right body asymmetry. PCD is mostly caused by mutations affecting the core axoneme structure of motile cilia that is essential for movement. Genes that cause PCD when mutated include a group that encode proteins essential for the assembly of the ciliary dynein motors and the active transport process that delivers them from their cytoplasmic assembly site into the axoneme...
May 3, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29717349/the-release-of-cytochrome-c-and-the-regulation-of-the-programmed-cell-death-progress-in-the-endosperm-of-winter-wheat-triticum-aestivum-l-under-waterlogging
#17
Yuan-Hong Qi, Fang-Fang Mao, Zhu-Qing Zhou, Dong-Cheng Liu, Min-Yu, Xiang-Yi Deng, Ji-Wei Li, Fang-Zhu Mei
It has been shown in mammalian systems that the mitochondria can play a key role in the regulation of apoptosis by releasing intermembrane proteins (such as cytochrome c) into the cytosol. Cytochrome c released from the mitochondria to the cytoplasm activates proteolytic enzyme cascades, leading to specific nuclear DNA degradation and cell death. This pathway is considered to be one of the important regulatory mechanisms of apoptosis. Previous studies have shown that endosperm cell development in wheat undergoes specialized programmed cell death (PCD) and that waterlogging stress accelerates the PCD process; however, little is known regarding the associated molecular mechanism...
May 2, 2018: Protoplasma
https://www.readbyqxmd.com/read/29713332/coordination-between-ros-regulatory-systems-and-other-pathways-under-heat-stress-and-pathogen-attack
#18
REVIEW
Nobuhiro Suzuki, Kazuma Katano
Regulatory systems of reactive oxygen species (ROS) are known to be integrated with other pathways involving Ca2+ signaling, protein kinases, hormones and programmed cell death (PCD) pathways to regulate defense mechanisms in plants. Coordination between ROS regulatory systems and other pathways needs to be flexibly modulated to finely tune the mechanisms underlying responses of different types of tissues to heat stress, biotic stresses and their combinations during different growth stages. Especially, modulation of the delicate balance between ROS-scavenging and producing systems in reproductive tissues could be essential, because ROS-dependent PCD is required for the proper fertilization, despite the necessity of ROS scavenging to prevent the damage on cells under heat stress and biotic stresses...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29701417/surgical-thrombectomy-fibrinolysis-angioplasty-and-stenting-a-combined-approach-for-treatment-of-a-may-thurner-syndrome-presenting-as-phlegmasia-cerulea-dolens
#19
Carlos Veiga, João Gonçalves, Pedro Sousa, Carolina Vaz, Ivone Silva, Pedro Sá-Pinto, Rui Almeida
INTRODUCTION: Phlegmasia cerulea dolens (PCD) is a rare complication of deep venous thrombosis (DVT). Massive ileo-femoral DVT is usually the cause and prompt treatment is mandatory as it represents a medical emergency. Reported amputation rates range from 12% to 25% and mortality ranges from 25% to 40%. Limb ischemia results from obstruction to arterial inflow secondary to extreme levels of venous hypertension. Primary treatment goal is restoration of venous outflow and can be achieved by endovascular or surgical techniques...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29686365/multifunctional-activities-of-erf109-as-affected-by-salt-stress-in-arabidopsis
#20
Ahmed Bahieldin, Ahmed Atef, Sherif Edris, Nour O Gadalla, Ahmed M Ramadan, Sabah M Hassan, Sanaa G Al Attas, Magdy A Al-Kordy, Abdulrahman S M Al-Hajar, Jamal S M Sabir, Mahmoud E Nasr, Gamal H Osman, Fotouh M El-Domyati
Transcriptomic analysis was conducted in leaves of Arabidopsis T-DNA insertion ERF109-knocked out (KO) mutant or plants overexpressing (OE) the gene to detect its role in driving expression of programmed cell death- (PCD-) or growth-related genes under high salt (200 mM NaCl) stress. The analysis yielded ~22-24 million reads, of which 90% mapped to the Arabidopsis reference nuclear genome. Hierarchical cluster analysis of gene expression and principal component analysis (PCA) successfully separated transcriptomes of the two stress time points...
April 23, 2018: Scientific Reports
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