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atherosclerosis and senescence

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https://www.readbyqxmd.com/read/28549747/increased-dipeptidyl-peptidase-4-accelerates-diet-related-vascular-aging-and-atherosclerosis-in-apoe-deficient-mice-under-chronic-stress
#1
Yanna Lei, Guang Yang, Lina Hu, Limei Piao, Aiko Inoue, Haiying Jiang, Takeshi Sasaki, Guangxian Zhao, Maimaiti Yisireyili, Chenglin Yu, Wenhu Xu, Kyosuke Takeshita, Kenji Okumura, Masafumi Kuzuya, Xian Wu Cheng
OBJECTIVES: Exposure to psychosocial stress is a risk factor for cardiovascular disease. Given that dipeptidyl peptidase-4 (DPP4) regulates several intracellular signaling pathways associated with glucagon-like peptide-1 (GLP-1) metabolism, we investigated the role of DPP4 in stress-related vascular senescence and atherosclerosis in apolipoprotein E-deficient (ApoE(-/-)) mice. METHODS AND RESULTS: ApoE(-/-) mice fed a high-fat (HF) diet were randomly assigned to one of non-stress and immobilized stress groups for 12weeks...
May 16, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28548953/from-rapalogs-to-anti-aging-formula
#2
Mikhail V Blagosklonny
Inhibitors of mTOR, including clinically available rapalogs such as rapamycin (Sirolimus) and Everolimus, are gerosuppressants, which suppress cellular senescence. Rapamycin slows aging and extends life span in a variety of species from worm to mammals. Rapalogs can prevent age-related diseases, including cancer, atherosclerosis, obesity, neurodegeneration and retinopathy and potentially rejuvenate stem cells, immunity and metabolism. Here, I further suggest how rapamycin can be combined with metformin, inhibitors of angiotensin II signaling (Losartan, Lisinopril), statins (simvastatin, atorvastatin), propranolol, aspirin and a PDE5 inhibitor...
May 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28499941/mtus1-a-gene-encoding-angiotensin-ii-type-2-at2-receptor-interacting-proteins-in-health-and-disease-with-special-emphasis-on-its-role-in-carcinogenesis
#3
REVIEW
Ibrahim Bozgeyik, Onder Yumrutas, Esra Bozgeyik
Loss of tumor suppressor activity is a frequent event in the formation and progression of tumors and has been listed as an important hallmark of cancers. Microtubule-Associated Scaffold Protein 1 (MTUS1) is a candidate tumor suppressor gene which is reported to be frequently down-regulated in a variety of human cancers including pancreas, colon, bladder, head-and-neck, ovarian, breast cancers, gastric, lung cancers. It is also reported to be implicated in several types of pathologies such as cardiac hypertrophy, atherosclerosis, and SLE-like lymphoproliferative diseases...
May 9, 2017: Gene
https://www.readbyqxmd.com/read/28490839/higher-order-chromatin-regulation-of-inflammatory-gene-expression
#4
REVIEW
Jin-Wen Xu, Shuang Ling, Jun Liu
Whether it is caused by viruses and bacteria infection, or low-grade chronic inflammation of atherosclerosis and cellular senescence, the transcription factor (TF) NF-κB plays a central role in the inducible expression of inflammatory genes. Accumulated evidence has indicated that the chromatin environment is the main determinant of TF binding in gene expression regulation, including the stimulus-responsive NF-κB. Dynamic changes in intra- and interchromosomes are the key regulatory mechanisms promoting the binding of TFs...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28487652/functional-gene-analysis-reveals-cell-cycle-changes-and-inflammation-in-endothelial-cells-irradiated-with-a-single-x-ray-dose
#5
Bjorn Baselet, Niels Belmans, Emma Coninx, Donna Lowe, Ann Janssen, Arlette Michaux, Kevin Tabury, Kenneth Raj, Roel Quintens, Mohammed A Benotmane, Sarah Baatout, Pierre Sonveaux, An Aerts
Background and Purpose: Epidemiological data suggests an excess risk of cardiovascular disease (CVD) at low doses (0.05 and 0.1 Gy) of ionizing radiation (IR). Furthermore, the underlying biological and molecular mechanisms of radiation-induced CVD are still unclear. Because damage to the endothelium could be critical in IR-related CVD, this study aimed to identify the effects of radiation on immortalized endothelial cells in the context of atherosclerosis. Material and Methods: Microarrays and RT-qPCR were used to compare the response of endothelial cells irradiated with a single X-ray dose (0...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28460648/endothelial-dysfunction-in-individuals-born-after-fetal-growth-restriction-cardiovascular-and-renal-consequences-and-preventive-approaches
#6
C Yzydorczyk, J B Armengaud, A C Peyter, H Chehade, F Cachat, C Juvet, B Siddeek, S Simoncini, F Sabatier, F Dignat-George, D Mitanchez, U Simeoni
Individuals born after intrauterine growth restriction (IUGR) have an increased risk of perinatal morbidity/mortality, and those who survive face long-term consequences such as cardiovascular-related diseases, including systemic hypertension, atherosclerosis, coronary heart disease and chronic kidney disease. In addition to the demonstrated long-term effects of decreased nephron endowment and hyperactivity of the hypothalamic-pituitary-adrenal axis, individuals born after IUGR also exhibit early alterations in vascular structure and function, which have been identified as key factors of the development of cardiovascular-related diseases...
May 2, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28411233/vasculopathy-in-the-setting-of-cardiorenal-syndrome-the-roles-of-protein-bound-uremic-toxins
#7
Jingbin Guo, Lu Lu, Yue Hua, Kevin Huang, Ian Wang, Li Huang, Qiang Fu, Aihua Chen, Paul Chan, Huimin Fan, Zhong-Min Liu, Bing Hui Wang
Chronic kidney disease (CKD) often leads to and accelerates the progression of cardiovascular disease (CVD), whilst CVD also causes kidney dysfunction. This bidirectional interaction leads to the development of a complex syndrome known as cardiorenal syndrome (CRS). CRS not only involves both the heart and the kidney, but also the vascular system through a vast array of contributing factors. In addition to hemodynamic, neuro-hormonal, mechanical and biochemical factors, the non-dialyzable protein-bound uremic toxins (PBUTs) are also key contributing factors that have been demonstrated through in vitro, in vivo and clinical observations...
April 14, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28389776/senotherapy-growing-old-and-staying-young
#8
REVIEW
Roland Schmitt
Cellular senescence, which has been linked to age-related diseases, occurs during normal aging or as a result of pathological cell stress. Due to their incapacity to proliferate, senescent cells cannot contribute to normal tissue maintenance and tissue repair. Instead, senescent cells disturb the microenvironment by secreting a plethora of bioactive factors that may lead to inflammation, regenerative dysfunction and tumor progression. Recent understanding of stimuli and pathways that induce and maintain cellular senescence offers the possibility to selectively eliminate senescent cells...
April 7, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28347738/dna-damage-dependent-mechanisms-of-ageing-and-disease-in-the-macro-and-microvasculature
#9
Aarti V Shah, Martin R Bennett
A decline in the function of the macro- and micro-vasculature occurs with ageing. DNA damage also accumulates with ageing, and thus DNA damage and repair have important roles in physiological ageing. Considerable evidence also supports a crucial role for DNA damage in the development and progression of macrovascular disease such as atherosclerosis. These findings support the concept that prolonged exposure to risk factors is a major stimulus for DNA damage within the vasculature, in part via the generation of reactive oxygen species...
March 24, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28259164/n-butanol-extracts-of-morinda-citrifolia-suppress-advanced-glycation-end-products-age-induced-inflammatory-reactions-in-endothelial-cells-through-its-anti-oxidative-properties
#10
Yuji Ishibashi, Takanori Matsui, Fumiyuki Isami, Yumi Abe, Tatsuya Sakaguchi, Yuichiro Higashimoto, Sho-Ichi Yamagishi
BACKGROUND: Advanced glycation end products (AGEs), senescent macroprotein derivatives formed during a normal aging process and acceleratedly under diabetic conditions, play a role in atherosclerotic cardiovascular disease. AGEs cause endothelial cell (EC) damage, an initial trigger for atherosclerosis through the interaction with a receptor for AGEs (RAGE). We have previously shown that n-butanol extracts of Morinda citrifolia (noni), a plant belonging to the family Rubiaceae, block the binding of AGEs to RAGE in vitro...
March 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28239687/protein-phosphatase-5-contributes-to-the-overexpression-of-epigenetically-regulated-t-lymphocyte-genes-in-patients-with-lupus
#11
D Patel, G Gorelik, B Richardson
OBJECTIVE: Lupus develops when genetically predisposed people encounter certain drugs or environmental agents causing oxidative stress such as infections and sun exposure, and then typically follows a chronic relapsing course with flares triggered by the exogenous stressors. Current evidence indicates that these environmental agents can trigger lupus flares by inhibiting the replication of DNA methylation patterns during mitosis in CD4(+) T cells, altering the expression of genes suppressed by this mechanism that convert normal "helper" cells into auto reactive cells which promote lupus flares...
December 2016: Lupus (Los Angeles)
https://www.readbyqxmd.com/read/28093411/age-and-sex-related-influences-on-left-ventricular-mechanics-in-elderly-individuals-free-of-prevalent-heart-failure-the-aric-study-atherosclerosis-risk-in-communities
#12
MULTICENTER STUDY
Chung-Lieh Hung, Alexandra Gonçalves, Amil M Shah, Susan Cheng, Dalane Kitzman, Scott D Solomon
BACKGROUND: Advanced age is related to left ventricular (LV) remodeling. We sought to investigate the relationships between aging, elevated hemodynamic load, cardiac mechanics, and LV remodeling in an elderly community-based population. METHODS AND RESULTS: We studied 1105 subjects (76±5 years, 61% women) without prevalent heart failure, who attended the visit 5 of the ARIC study (Atherosclerosis Risk in Communities). LV global longitudinal strain, global circumferential strain, and torsion indices were analyzed using 3-dimensional echocardiography...
January 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28092276/asialoglycoprotein-receptors-as-important-mediators-of-plasma-lipids-and-atherosclerosis
#13
Suleiman A Igdoura
PURPOSE OF REVIEW: This review seeks to describe the role of the asialoglycoprotein receptor (ASGR) in modulating non-HDL lipoprotein levels, platelet numbers and atherosclerosis. RECENT FINDINGS: Genetics studies have revealed that ASGR haplodeficiency provides protection from atherosclerosis. The potential interactions of ASGR with LDL receptor may regulate the rate of LDL uptake and as a result may lower plasma non-HDL cholesterol. ASGR clears senescent platelets and induces the expression of hepatic thrombopoietin...
January 13, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28079111/killing-the-old-cell-senescence-in-atherosclerosis
#14
Martin R Bennett, Murray C H Clarke
No abstract text is available yet for this article.
March 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28045034/premature-senescence-of-endothelial-cells-upon-chronic-exposure-to-tnf%C3%AE-can-be-prevented-by-n-acetyl-cysteine-and-plumericin
#15
Shafaat Y Khan, Ezzat M Awad, Andre Oszwald, Manuel Mayr, Xiaoke Yin, Birgit Waltenberger, Hermann Stuppner, Markus Lipovac, Pavel Uhrin, Johannes M Breuss
Cellular senescence is characterized by a permanent cell-cycle arrest and a pro-inflammatory secretory phenotype, and can be induced by a variety of stimuli, including ionizing radiation, oxidative stress, and inflammation. In endothelial cells, this phenomenon might contribute to vascular disease. Plasma levels of the inflammatory cytokine tumor necrosis factor alpha (TNFα) are increased in age-related and chronic conditions such as atherosclerosis, rheumatoid arthritis, psoriasis, and Crohn's disease. Although TNFα is a known activator of the central inflammatory mediator NF-κB, and can induce the intracellular generation of reactive oxygen species (ROS), the question whether TNFα can induce senescence has not been answered conclusively...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28039570/different-transcriptional-profiling-between-senescent-and-non-senescent-human-coronary-artery-endothelial-cells-hcaecs-by-omeprazole-and-lansoprazole-treatment
#16
Laura Costarelli, Robertina Giacconi, Marco Malavolta, Andrea Basso, Francesco Piacenza, Mauro Provinciali, Marcello G Maggio, Andrea Corsonello, Fabrizia Lattanzio
Recent evidence suggests that high dose and/or long term use of proton pump inhibitors (PPIs) may increase the risk of adverse cardiovascular events in older patients, but mechanisms underlying these detrimental effects are not known. Taking into account that the senescent endothelial cells have been implicated in the genesis or promotion of age-related cardiovascular disease, we hypothesized an active role of PPIs in senescent cells. The aim of this study is to investigate the changes in gene expression occurring in senescent and non-senescent human coronary artery endothelial cells (HCAECs) following Omeprazole (OPZ) or Lansoprazole (LPZ) treatment...
December 30, 2016: Biogerontology
https://www.readbyqxmd.com/read/28026009/transcriptomic-profiling-of-platelet-senescence-and-platelet-extracellular-vesicles
#17
Annika Pienimaeki-Roemer, Tatiana Konovalova, Melina M Musri, Alexander Sigruener, Alfred Boettcher, Gunter Meister, Gerd Schmitz
BACKGROUND: Platelets (PLTs) are derived from megakaryocytes during PLT shedding. Senescent or activated PLTs are expanded in vascular and neurological diseases and release PLT extracellular vesicles (PL-EVs). A systematic analysis of regular messenger RNA (mRNA) and small RNA composition in PLTs and PL-EVs during in vitro PLT senescence has not yet been published. STUDY DESIGN AND METHODS: We isolated PLTs, total PL-EVs, and PL-EV subsets on Days 0 and 5 from human stored donor platelet concentrates...
January 2017: Transfusion
https://www.readbyqxmd.com/read/28013216/diesel-exhaust-particles-contribute-to-endothelia-apoptosis-via-autophagy-pathway
#18
Jhih-Syuan Wang, Chia-Yi Tseng, Ming-Wei Chao
Epidemiological studies suggest that an increase of PM2.5 diesel exhaust particles (DEP) in ambient air corresponds to increased myocardial infarctions and atherosclerosis. When exposed to DEP, endothelial cells exhibit increases in oxidative stress and apoptosis, but the role of autophagy in this DEP-induced cell death remains unclear. Here, we suggest that acute DEP exposure produces intracellular reactive oxygen species (ROS) leading to induction of DEP internalization, endothelial dysfunction, and pro-inflammation in an in vitro human umbilical vein endothelial cells (HUVEC) model...
March 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27974178/assisted-living-in-the-atheroma-elderly-macrophages-promote-plaques
#19
Peter Libby
Age dominates as a risk factor for human atherosclerosis, yet the underlying mechanisms remain elusive. A recent report described accumulation of senescent cells in atheromata of hypercholesterolemic mice and provides novel insights into how genes expressed by aging cells associate with the characteristics of human plaques implicated in cardiovascular events.
December 13, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27941859/basic-research-killing-the-old-cell-senescence-in-atherosclerosis
#20
Martin R Bennett, Murray C H Clarke
No abstract text is available yet for this article.
December 12, 2016: Nature Reviews. Cardiology
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