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JOURNAL ARTICLE
Jun Hu, Zhen Wang, Gordon D Z Williams, Gary S Dwyer, Luke Gatiboni, Owen W Duckworth, Avner Vengosh
Phosphate fertilizers may contain elevated concentrations of toxic metals and metalloids and therefore, their excessive application can result in the accumulation of both phosphorus (P) and metal(loid)s in agricultural soils. This study aims to investigate the occurrence, distribution, and potential plant-availability of metal(loid)s originating from phosphate fertilizer in a long-term experimental field at the Tidewater Research Station in North Carolina, where topsoil (10-20 cm deep) and subsoil (up to 150 cm deep) samples were collected from five plots with consistent and individually different application rates of P-fertilizer since 1966...
October 26, 2023: Science of the Total Environment
#22
Santosh Karnewar, Vaishnavi Karnewar, Rebecca Deaton, Laura S Shankman, Ernest D Benavente, Corey M Williams, Xenia Bradley, Gabriel F Alencar, Gamze B Bulut, Sara Kirmani, Richard A Baylis, Eli R Zunder, Hester M den Ruijter, Gerard Pasterkamp, Gary K Owens
BACKGROUND: Thromboembolic events secondary to rupture or erosion of advanced atherosclerotic lesions are the leading cause of death in the world. The most common and effective means to reduce these major adverse cardiovascular events (MACE), including myocardial infarction (MI) and stroke, is aggressive lipid lowering via a combination of drugs and dietary modifications. However, little is known regarding the effects of reducing dietary lipids on the composition and stability of advanced atherosclerotic lesions, the mechanisms that regulate these processes, and what therapeutic approaches might augment the benefits of lipid lowering...
October 14, 2023: bioRxiv
#23
JOURNAL ARTICLE
David J Tunnicliffe, Samantha Bateman, Melissa Arnold-Chamney, Karen M Dwyer, Martin Howell, Azaria Gebadi, Shilpa Jesudason, Janet Kelly, Kelly Lambert, Sandawan William Majoni, Dora Oliva, Kelli J Owen, Odette Pearson, Elizabeth Rix, Ieyesha Roberts, Kimberly Taylor, Gary A Wittert, Katherine Widders, Adela Yip, Jonathan Craig, Richard K Phoon
INTRODUCTION: First Nations Australians display remarkable strength and resilience despite the intergenerational impacts of ongoing colonisation. The continuing disadvantage is evident in the higher incidence, prevalence, morbidity and mortality of chronic kidney disease (CKD) among First Nations Australians. Nationwide community consultation (Kidney Health Australia, Yarning Kidneys, and Lowitja Institute, Catching Some Air) identified priority issues for guideline development. These guidelines uniquely prioritised the knowledge of the community, alongside relevant evidence using an adapted GRADE Evidence to Decision framework to develop specific recommendations for the management of CKD among First Nations Australians...
October 16, 2023: Medical Journal of Australia
#24
JOURNAL ARTICLE
Shane G Downes, Rebecca A Owens, Kieran Walshe, David A Fitzpatrick, Amber Dorey, Gary W Jones, Sean Doyle
Overcoming antimicrobial resistance represents a formidable challenge and investigating bacterial growth inhibition by fungal metabolites may yield new strategies. Although the fungal non-ribosomal peptide gliotoxin (GT) is known to exhibit antibacterial activity, the mechanism(s) of action are unknown, although reduced gliotoxin (dithiol gliotoxin; DTG) is a zinc chelator. Furthermore, it has been demonstrated that GT synergises with vancomycin to inhibit growth of Staphylococcus aureus. Here we demonstrate, without precedent, that GT-mediated growth inhibition of both Gram positive and negative bacterial species is reversed by Zn2+ or Cu2+ addition...
September 27, 2023: Scientific Reports
#25
JOURNAL ARTICLE
Rune Boen, Tobias Kaufmann, Dennis van der Meer, Oleksandr Frei, Ingrid Agartz, David Ames, Micael Andersson, Nicola J Armstrong, Eric Artiges, Joshua R Atkins, Jochen Bauer, Francesco Benedetti, Dorret I Boomsma, Henry Brodaty, Katharina Brosch, Randy L Buckner, Murray J Cairns, Vince Calhoun, Svenja Caspers, Sven Cichon, Aiden P Corvin, Benedicto Crespo Facorro, Udo Dannlowski, Friederike S David, Eco J C de Geus, Greig I de Zubicaray, Sylvane Desrivières, Joanne L Doherty, Gary Donohoe, Stefan Ehrlich, Else Eising, Thomas Espeseth, Simon E Fisher, Andreas J Forstner, Lidia Fortaner Uyà, Vincent Frouin, Masaki Fukunaga, Tian Ge, David C Glahn, Janik Goltermann, Hans J Grabe, Melissa J Green, Nynke A Groenewold, Dominik Grotegerd, Tim Hahn, Ryota Hashimoto, Jayne Y Hehir-Kwa, Frans A Henskens, Avram J Holmes, Asta K Haberg, Jan Haavik, Sebastien Jacquemont, Andreas Jansen, Christiane Jockwitz, Erik G Jonsson, Masataka Kikuchi, Tilo Kircher, Kuldeep Kumar, Stephanie Le Hellard, Costin Leu, David E Linden, Jingyu Liu, Robert Loughnan, Karen A Mather, Katie L McMahon, Allan F McRae, Sarah E Medland, Susanne Meinert, Clara A Moreau, Derek W Morris, Bryan J Mowry, Thomas W Muhleisen, Igor Nenadić, Markus M Nöthen, Lars Nyberg, Michael J Owen, Marco Paolini, Tomas Paus, Zdenka Pausova, Karin Persson, Yann Quidé, Tiago Reis Marques, Perminder S Sachdev, Sigrid B Sando, Ulrich Schall, Rodney J Scott, Geir Selbæk, Elena Shumskaya, Ana I Silva, Sanjay M Sisodiya, Frederike Stein, Dan J Stein, Benjamin Straube, Fabian Streit, Lachlan T Strike, Alexander Teumer, Lea Teutenberg, Anbupalam Thalamuthu, Paul A Tooney, Diana Tordesillas-Gutierrez, Julian N Trollor, Dennis van 't Ent, Marianne B M van den Bree, Neeltje E M van Haren, Javier Vazquez-Bourgon, Henry Volzke, Wei Wen, Katharina Wittfeld, Christopher R K Ching, Lars T Westlye, Paul M Thompson, Carrie E Bearden, Kaja K Selmer, Dag Alnæs, Ole A Andreassen, Ida E Sonderby
BACKGROUND: The 1q21.1 distal and 15q11.2 BP1-BP2 CNVs exhibit regional and global brain differences compared to non-carriers. However, interpreting regional differences is challenging if a global difference drives the regional brain differences. Intra-individual variability measures can be used to test for regional differences beyond global differences in brain structure. METHODS: Magnetic resonance imaging data were used to obtain regional brain values for 1q21...
September 1, 2023: Biological Psychiatry
#26
JOURNAL ARTICLE
Yalin Yang, Qiuting Yan, Xiulan Weng, Gary Owens, Zuliang Chen
While rare earth elements (REEs) play key roles in many modern technologies, the selectivity of recovering of REEs from mining wastewater remains a critical problem. In this study, iron nanoparticles (FeNPs) synthesized from euphorbia cochinchinensis extracts were successfully used for selective recovery of REEs from real mining wastewater with removal efficiencies of 89.4% for Y(III), 79.8% for Ce(III) and only 6.15% for Zn(Ⅱ). FTIR and XPS analysis suggested that the high selective removal efficiency of Y(III) and Ce(III) relative to Zn(Ⅱ) on FeNPs was due to a combination of selective REEs adsorption via complexing with O or N, ion exchange with H+ present in functional groups contained within the capping layer and electrostatic interactions...
August 13, 2023: Water Research
#27
JOURNAL ARTICLE
Ernest Diez Benavente, Santosh Karnewar, Michele Buono, Eloi Mili, Robin J G Hartman, Daniek Kapteijn, Lotte Slenders, Mark Daniels, Redouane Aherrahrou, Tobias Reinberger, Barend M Mol, Gert J de Borst, Dominique P V de Kleijn, Koen H M Prange, Marie A C Depuydt, Menno P J de Winther, Johan Kuiper, Johan L M Björkegren, Jeanette Erdmann, Mete Civelek, Michal Mokry, Gary K Owens, Gerard Pasterkamp, Hester M den Ruijter
BACKGROUND: Women presenting with coronary artery disease more often present with fibrous atherosclerotic plaques, which are currently understudied. Phenotypically modulated smooth muscle cells (SMCs) contribute to atherosclerosis in women. How these phenotypically modulated SMCs shape female versus male plaques is unknown. METHODS: Gene regulatory networks were created using RNAseq gene expression data from human carotid atherosclerotic plaques. The networks were prioritized based on sex bias, relevance for smooth muscle biology, and coronary artery disease genetic enrichment...
August 17, 2023: Arteriosclerosis, Thrombosis, and Vascular Biology
#28
Santosh Karnewar, Vaishnavi Karnewar, Laura S Shankman, Gary K Owens
UNLABELLED: The use of senolytic agents to remove senescent cells from atherosclerotic lesions is controversial. A common limitation of previous studies is the failure to rigorously define the effects of senolytic agent ABT-263 (Navitoclax) on smooth muscle cells (SMC) despite studies claiming that they are the major source of senescent cells. Moreover, there are no studies of the effect of ABT-263 on endothelial cells (EC), which along with SMC comprise 90% of α-SMA + myofibroblast-like cells in the protective fibrous cap...
July 13, 2023: bioRxiv
#29
JOURNAL ARTICLE
Joy Y Wang, Owen T Tuck, Petr Skopintsev, Katarzyna M Soczek, Gary Li, Basem Al-Shayeb, Julia Zhou, Jennifer A Doudna
CRISPR-Cas adaptive immune systems capture DNA fragments from invading mobile genetic elements and integrate them into the host genome to provide a template for RNA-guided immunity1 . CRISPR systems maintain genome integrity and avoid autoimmunity by distinguishing between self and non-self, a process for which the CRISPR/Cas1-Cas2 integrase is necessary but not sufficient2-5 . In some microorganisms, the Cas4 endonuclease assists CRISPR adaptation6,7 , but many CRISPR-Cas systems lack Cas48 . Here we show here that an elegant alternative pathway in a type I-E system uses an internal DnaQ-like exonuclease (DEDDh) to select and process DNA for integration using the protospacer adjacent motif (PAM)...
June 14, 2023: Nature
#30
JOURNAL ARTICLE
Noah D Silverberg, Grant L Iverson, Alison Cogan, Kristen Dams-O-Connor, Richard Delmonico, Min Jeong P Graf, Mary Alexis Iaccarino, Maria Kajankova, Joshua Kamins, Karen L McCulloch, Gary McKinney, Drew Nagele, William J Panenka, Amanda R Rabinowitz, Nick Reed, Jennifer V Wethe, Victoria Whitehair, Vicki Anderson, David B Arciniegas, Mark T Bayley, Jeffery J Bazarian, Kathleen R Bell, Steven P Broglio, David Cifu, Gavin A Davis, Jiri Dvorak, Ruben J Echemendia, Gerard A Gioia, Christopher C Giza, Sidney R Hinds, Douglas I Katz, Brad G Kurowski, John J Leddy, Natalie Le Sage, Angela Lumba-Brown, Andrew Ir Maas, Geoffrey T Manley, Michael McCrea, David K Menon, Jennie Ponsford, Margot Putukian, Stacy J Suskauer, Joukje van der Naalt, William C Walker, Keith Owen Yeates, Ross Zafonte, Nathan D Zasler, Roger Zemek
OBJECTIVE: To develop new diagnostic criteria for mild traumatic brain injury (TBI) that are appropriate for use across the lifespan and in sports, civilian trauma, and military settings. DESIGN: Rapid evidence reviews on 12 clinical questions and Delphi method for expert consensus. PARTICIPANTS: The Mild Traumatic Brain Injury Task Force of the American Congress of Rehabilitation Medicine Brain Injury Special Interest Group convened a Working Group of 17 members and an external interdisciplinary expert panel of 32 clinician-scientists...
August 2023: Archives of Physical Medicine and Rehabilitation
#31
JOURNAL ARTICLE
Vlad Serbulea, Rebecca A Deaton, Gary K Owens
No abstract text is available yet for this article.
January 2023: Nature aging
#32
JOURNAL ARTICLE
Shraddha Pai, Shirley Hui, Philipp Weber, Soumil Narayan, Owen Whitley, Peipei Li, Viviane Labrie, Jan Baumbach, Anne L Wheeler, Gary D Bader
An open challenge in human genetics is to better understand the systems-level impact of genotype variation on developmental cognition. To characterize the genetic underpinnings of peri-adolescent cognition, we performed genotype-phenotype and systems analysis for binarized accuracy in nine cognitive tasks from the Philadelphia Neurodevelopmental Cohort (~2,200 individuals of European continental ancestry aged 8-21 years). We report a region of genome-wide significance within the 3' end of the Fibulin-1 gene (P = 4...
April 27, 2023: Cerebral Cortex
#33
JOURNAL ARTICLE
Alice C Harnden, Owen A Davis, Gary M Box, Angela Hayes, Louise D Johnson, Alan T Henley, Alexis K de Haven Brandon, Melanie Valenti, Kwai-Ming J Cheung, Alfie Brennan, Rosemary Huckvale, Olivier A Pierrat, Rachel Talbot, Michael D Bright, Hafize Aysin Akpinar, Daniel S J Miller, Dalia Tarantino, Sharon Gowan, Selby de Klerk, Peter Craig McAndrew, Yann-Vaï Le Bihan, Mirco Meniconi, Rosemary Burke, Vladimir Kirkin, Rob L M van Montfort, Florence I Raynaud, Olivia W Rossanese, Benjamin R Bellenie, Swen Hoelder
B-cell lymphoma 6 (BCL6) is a transcriptional repressor and oncogenic driver of diffuse large B-cell lymphoma (DLBCL). Here, we report the optimization of our previously reported tricyclic quinolinone series for the inhibition of BCL6. We sought to improve the cellular potency and in vivo exposure of the non-degrading isomer, CCT373567 , of our recently published degrader, CCT373566 . The major limitation of our inhibitors was their high topological polar surface areas (TPSA), leading to increased efflux ratios...
April 7, 2023: Journal of Medicinal Chemistry
#34
JOURNAL ARTICLE
Christopher Green, Antoaneta Bilyanska, Mags Bradley, Jason Dinsdale, Lorraine Hutt, Thomas Backhaus, Frank Boons, David Bott, Chris Collins, Sarah E Cornell, Mark Craig, Michael Depledge, Bob Diderich, Richard Fuller, Tamara S Galloway, Gary R Hutchison, Nicola Ingrey, Andrew C Johnson, Rachael Kupka, Peter Matthiessen, Robin Oliver, Stewart Owen, Susan Owens, John Pickett, Sam Robinson, Kerry Sims, Pete Smith, John P Sumpter, Svetlana Tretsiakova-McNally, Mengjiao Wang, Tom Welton, Katherine J Willis, Iseult Lynch
Whilst chemicals are vital to modern society through materials, agriculture, textiles, new technology, medicines and consumer goods, their use is not without risks. Unfortunately, our resources seem inadequate to address the breadth of chemicals challenges to the environment and human health. Therefore, it is important we use our intelligence and knowledge wisely to prepare for what lies ahead. This study used a Delphi-style approach to horizon scan future chemical threats that need to be considered in the setting of chemicals and environmental policy, which involved a multi-disciplinary, multi-sectoral and multi-national panel of 25 scientists and practitioners (mainly from the UK, Europe and other industrialised nations) in a 3-stage process...
March 27, 2023: Environmental Toxicology and Chemistry
#35
Margarete Diaz-Cuadros, Teemu P Miettinen, Owen S Skinner, Dylan Sheedy, Carlos Manlio Díaz-García, Svetlana Gapon, Alexis Hubaud, Gary Yellen, Scott R Manalis, William M Oldham, Olivier Pourquié
No abstract text is available yet for this article.
March 22, 2023: Nature
#36
JOURNAL ARTICLE
Kevin W Southern, Carlo Castellani, Elise Lammertyn, Alan Smyth, Donald VanDevanter, Silke van Koningsbruggen-Rietschel, Jürg Barben, Amanda Bevan, Edwin Brokaar, Sarah Collins, Gary J Connett, Thomas W V Daniels, Jane Davies, Dimitri Declercq, Silvia Gartner, Andrea Gramegna, Naomi Hamilton, Jenny Hauser, Nataliya Kashirskaya, Laurence Kessler, Jacqueline Lowdon, Halyna Makukh, Clémence Martin, Lisa Morrison, Dilip Nazareth, Jacquelien Noordhoek, Ciaran O'Neill, Elizabeth Owen, Helen Oxley, Karen S Raraigh, Caroline Raynal, Karen Robinson, Jobst Roehmel, Carsten Schwarz, Isabelle Sermet, Michal Shteinberg, Ian Sinha, Constance Takawira, Peter van Mourik, Marieke Verkleij, Michael D Waller, Alistair Duff
Cystic fibrosis (CF) has entered the era of variant-specific therapy, tailored to the genetic variants in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CFTR modulators, the first variant-specific therapy available, have transformed the management of CF. The latest standards of care from the European CF Society (2018) did not include guidance on variant-specific therapy, as CFTR modulators were becoming established as a novel therapy. We have produced interim standards to guide healthcare professionals in the provision of variant-specific therapy for people with CF...
January 2023: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
#37
JOURNAL ARTICLE
Shane G Downes, Sean Doyle, Gary W Jones, Rebecca A Owens
Antimicrobial resistance (AMR) is a major global problem and threat to humanity. The search for new antibiotics is directed towards targeting of novel microbial systems and enzymes, as well as augmenting the activity of pre-existing antimicrobials. Sulphur-containing metabolites (e.g., auranofin and bacterial dithiolopyrrolones [e.g., holomycin]) and Zn2+-chelating ionophores (PBT2) have emerged as important antimicrobial classes. The sulphur-containing, non-ribosomal peptide gliotoxin, biosynthesised by Aspergillus fumigatus and other fungi exhibits potent antimicrobial activity, especially in the dithiol form (dithiol gliotoxin; DTG)...
March 6, 2023: Essays in Biochemistry
#38
Ernest Diez Benavente, Santosh Karnewar, Michele Buono, Eloi Mili, Robin J G Hartman, Daniek Kapteijn, Lotte Slenders, Mark Daniels, Redouane Aherrahrou, Tobias Reinberger, Barend M Mol, Gert J de Borst, Dominique P V de Kleijn, Koen H M Prange, Marie A C Depuydt, Menno P J de Winther, Johan Kuiper, Johan L M Bj Rkegren, Jeanette Erdmann, Mete Civelek, Michal Mokry, Gary K Owens, Gerard Pasterkamp, Hester M den Ruijter
Women presenting with coronary artery disease (CAD) more often present with fibrous atherosclerotic plaques, which are currently understudied. Phenotypically modulated smooth muscle cells (SMCs) contribute to atherosclerosis in women. How these phenotypically modulated SMCs shape female versus male plaques is unknown. Here, we show sex-stratified gene regulatory networks (GRNs) from human carotid atherosclerotic tissue. Prioritization of these networks identified two main SMC GRNs in late-stage atherosclerosis...
February 9, 2023: bioRxiv
#39
JOURNAL ARTICLE
Xiaonan Cai, Chao Xue, Gary Owens, Zuliang Chen
While laccase oxidation is a novel and promising method for treating arsenite-containing wastewater, the high cost and unsustainability of commercially available enzymes indicate a need to investigate more cost-effective viable alternatives. Here, a microorganism sustained secrete laccase-straw oxidation system (MLOS) was established and subsequently evaluated for the removal of As(III). MLOS showed efficient biological As(III) oxidation, with an As(III) removal efficiency reaching 99.9% at an initial As(III) concentration of 1...
February 7, 2023: Journal of Hazardous Materials
#40
JOURNAL ARTICLE
Jing Wu, Xiulan Weng, Gary Owens, Zuliang Chen
As feed additives, oxytetracycline (OTC) and copper ion (Cu(II)) are often detected in livestock and poultry farming wastewater. To address this issue, firstly, the synthesis conditions of Fe/Mn nanoparticles (Fe/Mn NPs) were initially optimized using a response surface methodology (RSM) to yield highly active Fe/Mn NPs, where the application of RSM significantly increased the Fe/Mn NPs' efficiency in removing co-contamination OTC and Cu(II),respectively, from 45.8 to 86.2% and 14.9-67.2%. Secondly, scanning electron microscope and Nitrogen adsorption-desorption isotherms results showed that Fe/Mn NPs were composed of elliptic particles between 20 and 40 nm, a specific surface area of 59...
February 3, 2023: Chemosphere
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