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Keywords vascular smooth muscle cell pl...

vascular smooth muscle cell plasticity

https://read.qxmd.com/read/38458566/mustn1-is-a-smooth-muscle-cell-secreted-microprotein-that-modulates-skeletal-muscle-extracellular-matrix-composition
#1
JOURNAL ARTICLE
Serge Ducommun, Paulo R Jannig, Igor Cervenka, Marta Murgia, Melanie J Mittenbühler, Ekaterina Chernogubova, José M Dias, Baptiste Jude, Jorge C Correia, Jonathan G Van Vranken, Gabriel Ocana-Santero, Margareta Porsmyr-Palmertz, Sarah McCann Haworth, Vicente Martínez-Redondo, Zhengye Liu, Mattias Carlström, Matthias Mann, Johanna T Lanner, Ana I Teixeira, Lars Maegdefessel, Bruce M Spiegelman, Jorge L Ruas
OBJECTIVE: Skeletal muscle plasticity and remodeling are critical for adapting tissue function to use, disuse, and regeneration. The aim of this study was to identify genes and molecular pathways that regulate the transition from atrophy to compensatory hypertrophy or recovery from injury. Here, we have used a mouse model of hindlimb unloading and reloading, which causes skeletal muscle atrophy, and compensatory regeneration and hypertrophy, respectively. METHODS: We analyzed mouse skeletal muscle at the transition from hindlimb unloading to reloading for changes in transcriptome and extracellular fluid proteome...
March 6, 2024: Molecular Metabolism
https://read.qxmd.com/read/38369010/exposure-to-tcbpa-stimulates-the-growth-of-arterial-smooth-muscle-cells-through-the-activation-of-the-ros-nf-%C3%AE%C2%BAb-nlrp3-signaling-pathway
#2
JOURNAL ARTICLE
Huanyu Qiao, Bo Yang, Xiaoshuo Lv, Yongmin Liu
Tetrachlorobisphenol A (TCBPA) and Tetrabromobisphenol S (TBBPS) are organic compounds widely used in industrial production, including in plastic and textile manufacturing. Presently, residual TCBPA is commonly detected in the environment as well as in human and animal sera. Therefore, it is imperative to assess the potential toxicological effects of TCBPA on organismal health. A series of biochemical experiments, including indirect immunofluorescence, ELISA, Western blot, MTT, etc, were conducted to analyze the effects of TCBPA on vascular smooth muscle cells...
February 16, 2024: Toxicology
https://read.qxmd.com/read/38345905/arterial-stiffness-from-basic-primers-to-integrative-physiology
#3
REVIEW
Véronique Regnault, Patrick Lacolley, Stéphane Laurent
The elastic properties of conductance arteries are one of the most important hemodynamic functions in the body, and data continue to emerge regarding the importance of their dysfunction in vascular aging and a range of cardiovascular diseases. Here, we provide new insight into the integrative physiology of arterial stiffening and its clinical consequence. We also comprehensively review progress made on pathways/molecules that appear today as important basic determinants of arterial stiffness, particularly those mediating the vascular smooth muscle cell (VSMC) contractility, plasticity and stiffness...
February 12, 2024: Annual Review of Physiology
https://read.qxmd.com/read/38291732/phenotypic-switching-of-vascular-smooth-muscle-cells-in-atherosclerosis-hypertension-and-aortic-dissection
#4
REVIEW
Mohamed Elmarasi, Ibrahim Elmakaty, Basel Elsayed, Abdelrahman Elsayed, Jana Al Zein, Ammar Boudaka, Ali H Eid
Vascular smooth muscle cells (VSMCs) play a critical role in regulating vasotone, and their phenotypic plasticity is a key contributor to the pathogenesis of various vascular diseases. Two main VSMC phenotypes have been well described: contractile and synthetic. Contractile VSMCs are typically found in the tunica media of the vessel wall, and are responsible for regulating vascular tone and diameter. Synthetic VSMCs, on the other hand, are typically found in the tunica intima and adventitia, and are involved in vascular repair and remodeling...
January 30, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38280419/omics-approaches-unveiling-the-biology-of-human-atherosclerotic-plaques
#5
REVIEW
Xun Wu, Hanrui Zhang
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the buildup of plaques with the accumulation and transformation of lipids, immune cells, vascular smooth muscle cells, and necrotic cell debris. Plaques with collagen-poor thin fibrous caps infiltrated by macrophages and lymphocytes are considered unstable because they are at the greatest risk of rupture and clinical events. However, the current histological definition of plaque types may not fully capture the complex molecular nature of atherosclerotic plaque biology and the underlying mechanisms contributing to plaque progression, rupture, or erosion...
January 25, 2024: American Journal of Pathology
https://read.qxmd.com/read/38247859/swi-snf-complex-in-vascular-smooth-muscle-cells-and-its-implications-in-cardiovascular-pathologies
#6
REVIEW
Hongyu Liu, Yang Zhao, Guizhen Zhao, Yongjie Deng, Y Eugene Chen, Jifeng Zhang
Mature vascular smooth muscle cells (VSMC) exhibit a remarkable degree of plasticity, a characteristic that has intrigued cardiovascular researchers for decades. Recently, it has become increasingly evident that the chromatin remodeler SWItch/Sucrose Non-Fermentable (SWI/SNF) complex plays a pivotal role in orchestrating chromatin conformation, which is critical for gene regulation. In this review, we provide a summary of research related to the involvement of the SWI/SNF complexes in VSMC and cardiovascular diseases (CVD), integrating these discoveries into the current landscape of epigenetic and transcriptional regulation in VSMC...
January 16, 2024: Cells
https://read.qxmd.com/read/38216067/gamut-of-glycolytic-enzymes-in-vascular-smooth-muscle-cell-proliferation-implications-for-vascular-proliferative-diseases
#7
REVIEW
Ankan Sarkar, Sandip V Pawar, Kanwaljit Chopra, Manish Jain
Vascular smooth muscle cells (VSMCs) are the predominant cell type in the media of the blood vessels and are responsible for maintaining vascular tone. Emerging evidence confirms that VSMCs possess high plasticity. During vascular injury, VSMCs switch from a "contractile" phenotype to an extremely proliferative "synthetic" phenotype. The balance between both strongly affects the progression of vascular remodeling in many cardiovascular pathologies such as restenosis, atherosclerosis and aortic aneurism. Proliferating cells demand high energy requirements and to meet this necessity, alteration in cellular bioenergetics seems to be essential...
January 10, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38154651/a-novel-tirna-glu-ctc-induces-nanoplastics-accelerated-vascular-smooth-muscle-cell-phenotypic-switching-and-vascular-injury-through-mitochondrial-damage
#8
JOURNAL ARTICLE
Min Zhang, Jun Shi, Huichao Pan, Jie Zhu, Xueting Wang, Lei Song, Huiping Deng
Nanoplastics pose several health hazards, especially vascular toxicity. Transfer RNA-derived small RNAs (tsRNAs) are novel noncoding RNAs associated with different pathological processes. However, their biological roles and mechanisms in aberrant vascular smooth muscle cell (VSMC) plasticity and vascular injury are unclear. This study investigated the potent effects of tsRNAs on vascular injury induced by short- and long-term exposure to polystyrene nanoplastics (PS-NPs). Mice were exposed to PS-NPs (100 nm) at different doses (10-100 μg/mL) for 30 or 180 days...
December 26, 2023: Science of the Total Environment
https://read.qxmd.com/read/38153414/expression-of-cd31-cd34-and-smooth-muscle-actin-sma-in-endothelial-cells-of-dental-pulp-vessels
#9
JOURNAL ARTICLE
Ana Tenyi, Aleksandra Milutinović, Lidija Nemeth
The dental pulp is a highly vascularized and innervated loose connective tissue surrounded by hard dental tissues - enamel and dentine. With the primary dentin formation and the closure of the root apex, the conditions in the dental pulp change and pulp tissue compliance are reduced. Endothelial cells of pulpal blood vessels are highly differentiated and are capable of adaptation to changes in the environment. We aimed to evaluate the phenotypic plasticity of endothelial cells of pulpal blood vessels in permanent premolars with open (N = 6) or closed root apex (N = 30)...
December 28, 2023: Biomol Biomed
https://read.qxmd.com/read/38138649/in-vitro-investigation-of-gelatin-polycaprolactone-nanofibers-in-modulating-human-gingival-mesenchymal-stromal-cells
#10
JOURNAL ARTICLE
Zhiwei Tian, Zhongqi Zhao, Marco Aoqi Rausch, Christian Behm, Hassan Ali Shokoohi-Tabrizi, Oleh Andrukhov, Xiaohui Rausch-Fan
The aesthetic constancy and functional stability of periodontium largely depend on the presence of healthy mucogingival tissue. Soft tissue management is crucial to the success of periodontal surgery. Recently, synthetic substitute materials have been proposed to be used for soft tissue augmentation, but the tissue compatibility of these materials needs to be further investigated. This study aims to assess the in vitro responses of human gingival mesenchymal stromal cells (hG-MSCs) cultured on a Gelatin/Polycaprolactone prototype (GPP) and volume-stable collagen matrix (VSCM)...
December 5, 2023: Materials
https://read.qxmd.com/read/38089777/role-of-vascular-smooth-muscle-cell-clonality-in-atherosclerosis
#11
REVIEW
Lingfeng Luo, Changhao Fu, Caitlin F Bell, Ying Wang, Nicholas J Leeper
Atherosclerotic cardiovascular disease remains the leading cause of death worldwide. While many cell types contribute to the growing atherosclerotic plaque, the vascular smooth muscle cell (SMC) is a major contributor due in part to its remarkable plasticity and ability to undergo phenotype switching in response to injury. SMCs can migrate into the fibrous cap, presumably stabilizing the plaque, or accumulate within the lesional core, possibly accelerating vascular inflammation. How SMCs expand and react to disease stimuli has been a controversial topic for many decades...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38032545/effect-of-mechanical-stimuli-on-the-phenotypic-plasticity-of-induced-pluripotent-stem-cell-derived-vascular-smooth-muscle-cells-in-a-3d-hydrogel
#12
JOURNAL ARTICLE
Elana M Meijer, Rachel Giles, Christian G M van Dijk, Ranganath Maringanti, Tamar B Wissing, Ymke Appels, Ihsan Chrifi, Hanneke Crielaard, Marianne C Verhaar, Anthal I P M Smits, Caroline Cheng
Introduction: Vascular smooth muscle cells (VSMCs) play a pivotal role in vascular homeostasis, with dysregulation leading to vascular complications. Human-induced pluripotent stem-cell (hiPSC)-derived VSMCs offer prospects for personalized disease modeling and regenerative strategies. Current research lacks comparative studies on the impact of three-dimensional (3D) substrate properties under cyclic strain on phenotypic adaptation in hiPSC-derived VSMCs. Here, we aim to investigate the impact of intrinsic substrate properties, such as the hydrogel's elastic modulus and cross-linking density in a 3D static and dynamic environment, on the phenotypical adaptation of human mural cells derived from hiPSC-derived organoids (ODMCs), compared to aortic VSMCs...
November 30, 2023: ACS Applied Bio Materials
https://read.qxmd.com/read/37950869/integrative-single-cell-meta-analysis-reveals-disease-relevant-vascular-cell-states-and-markers-in-human-atherosclerosis
#13
JOURNAL ARTICLE
Jose Verdezoto Mosquera, Gaëlle Auguste, Doris Wong, Adam W Turner, Chani J Hodonsky, Astrid Catalina Alvarez-Yela, Yipei Song, Qi Cheng, Christian L Lino Cardenas, Konstantinos Theofilatos, Maxime Bos, Maryam Kavousi, Patricia A Peyser, Manuel Mayr, Jason C Kovacic, Johan L M Björkegren, Rajeev Malhotra, P Todd Stukenberg, Aloke V Finn, Sander W van der Laan, Chongzhi Zang, Nathan C Sheffield, Clint L Miller
Coronary artery disease (CAD) is characterized by atherosclerotic plaque formation in the arterial wall. CAD progression involves complex interactions and phenotypic plasticity among vascular and immune cell lineages. Single-cell RNA-seq (scRNA-seq) studies have highlighted lineage-specific transcriptomic signatures, but human cell phenotypes remain controversial. Here, we perform an integrated meta-analysis of 22 scRNA-seq libraries to generate a comprehensive map of human atherosclerosis with 118,578 cells...
November 9, 2023: Cell Reports
https://read.qxmd.com/read/37907652/nanopore-long-read-rna-sequencing-reveals-functional-alternative-splicing-variants-in-human-vascular-smooth-muscle-cells
#14
JOURNAL ARTICLE
Hao Wu, Yicheng Lu, Zhenzhen Duan, Jingni Wu, Minghui Lin, Yangjun Wu, Siyang Han, Tongqi Li, Yuqi Fan, Xiaoyuan Hu, Hongyan Xiao, Jiaxuan Feng, Zhiqian Lu, Deping Kong, Shengli Li
Vascular smooth muscle cells (VSMCs) are the major contributor to vascular repair and remodeling, which showed high level of phenotypic plasticity. Abnormalities in VSMC plasticity can lead to multiple cardiovascular diseases, wherein alternative splicing plays important roles. However, alternative splicing variants in VSMC plasticity are not fully understood. Here we systematically characterized the long-read transcriptome and their dysregulation in  human aortic smooth muscle cells (HASMCs) by employing the Oxford Nanopore Technologies long-read RNA sequencing in HASMCs that are separately treated with platelet-derived growth factor, transforming growth factor, and hsa-miR-221-3P transfection...
October 31, 2023: Communications Biology
https://read.qxmd.com/read/37820925/nuclear-control-of-vascular-smooth-muscle-cell-plasticity-during-vascular-remodeling
#15
REVIEW
Ibrahim Adeola Ahmed, Mingjun Liu, Delphine Gomez
Control of vascular smooth muscle cell (SMC) gene expression is an essential process for establishing and maintaining lineage identity, contractility, and plasticity. Most mechanisms (epigenetic, transcriptional, and post-transcriptional) implicated in gene regulation occur in the nucleus. Still, intranuclear pathways are directly impacted by modifications in the extracellular environment in conditions of adaptive or maladaptive remodeling. Integration of extracellular, cellular, and genomic information into the nucleus through epigenetic and transcriptional control of genome organization plays a major role in regulating SMC functions and phenotypic transitions during vascular remodeling and diseases...
October 9, 2023: American Journal of Pathology
https://read.qxmd.com/read/37815057/phenotypic-switching-of-vascular-smooth-muscle-cells-in-atherosclerosis
#16
REVIEW
Runji Chen, David G McVey, Daifei Shen, Xiaoxin Huang, Shu Ye
The medial layer of the arterial wall is composed mainly of vascular smooth muscle cells (VSMCs). Under physiological conditions, VSMCs assume a contractile phenotype, and their primary function is to regulate vascular tone. In contrast with terminally differentiated cells, VSMCs possess phenotypic plasticity, capable of transitioning into other cellular phenotypes in response to changes in the vascular environment. Recent research has shown that VSMC phenotypic switching participates in the pathogenesis of atherosclerosis, where the various types of dedifferentiated VSMCs accumulate in the atherosclerotic lesion and participate in the associated vascular remodeling by secreting extracellular matrix proteins and proteases...
October 10, 2023: Journal of the American Heart Association
https://read.qxmd.com/read/37744557/reprogramming-endothelial-and-vascular-smooth-muscle-cells-to-prevent-and-treat-hypertension
#17
JOURNAL ARTICLE
Laena Pernomian, Wenbin Tan, Cameron McCarthy, Camilla Ferreira Wenceslau
The major pathophysiological characteristic of hypertension is the occurrence of small artery remodeling and endothelial dysfunction. There is also solid evidence showing that microcirculation abnormalities occur prior to the onset of hypertension. However, the mechanism(s) that trigger these changes prior to the elevation of blood pressure are unknown, and this may limit our ability to identify the cause of this disease and effectively treat it. In hypertension, as with aging, the vasculature becomes less susceptible to repair...
October 2023: Medical Hypotheses
https://read.qxmd.com/read/37741880/vascular-smooth-muscle-cells-enhance-immune-vascular-interplay-in-a-3-cell-model-of-vascular-inflammation
#18
JOURNAL ARTICLE
Jolanta Wiejak, Fiona A Murphy, Pasquale Maffia, Stephen J Yarwood
Atherosclerosis is a serious cardiovascular disease that is characterised by the development of atheroma, which are lipid-laden plaques that build up within arterial walls due to chronic inflammatory processes. These lesions are fundamentally attributed to a complex cellular crosstalk between vascular smooth muscle cells (VSMCs), vascular endothelial cells (VECs) and central immune cells, such as macrophages (Mɸs), which promote vascular inflammation. The presence of VSMCs exerts both positive and negative effects during atheroma development, which can be attributed to their phenotypic plasticity...
September 23, 2023: Scientific Reports
https://read.qxmd.com/read/37709601/new-targets-in-atherosclerosis-vascular-smooth-muscle-cell-plasticity-and-macrophage-polarity
#19
REVIEW
Michael Hutton, Madeleine Frazer, Alexander Lin, Sanjay Patel, Ashish Misra
PURPOSE: Despite an increase in treatment options, and substantial reductions in cardiovascular mortality over the past half-century, atherosclerosis remains the most prevalent cause of premature mortality worldwide. The development of innovative new therapies is crucial to further minimize atherosclerosis-related deaths. The diverse array of cell phenotypes derived from vascular smooth muscle cells (SMCs) and macrophages within atherosclerotic plaques are increasingly becoming recognized for their beneficial and detrimental roles in plaque stability and disease burden...
September 12, 2023: Clinical Therapeutics
https://read.qxmd.com/read/37650555/smad4-a-critical-regulator-of-cardiac-neural-crest-cell-fate-and-vascular-smooth-muscle-development
#20
JOURNAL ARTICLE
Brianna E Alexander, Huaning Zhao, Sophie Astrof
BACKGROUND: During embryogenesis, cardiac neural crest-derived cells (NCs) migrate into the pharyngeal arches and give rise to the vascular smooth muscle cells (vSMCs) of the pharyngeal arch arteries (PAAs). vSMCs are critical for the remodeling of the PAAs into their final adult configuration, giving rise to the aortic arch and its arteries (AAAs). RESULTS: We investigated the role of SMAD4 in NC-to-vSMC differentiation using lineage-specific inducible mouse strains...
August 31, 2023: Developmental Dynamics
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