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Clinical Laboratory Science

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https://www.readbyqxmd.com/read/27903591/platelet-rich-plasma-powder-a-new-preparation-method-for-the-standardization-of-growth-factor-concentrations
#1
Matthias Kieb, Frank Sander, Cornelia Prinz, Stefanie Adam, Anett Mau-Möller, Rainer Bader, Kirsten Peters, Thomas Tischer
BACKGROUND: Platelet-rich plasma (PRP) is widely used in sports medicine. Available PRP preparations differ in white blood cell, platelet, and growth factor concentrations, making standardized research and clinical application challenging. PURPOSE: To characterize a newly standardized procedure for pooled PRP that provides defined growth factor concentrations. STUDY DESIGN: Controlled laboratory study. METHODS: A standardized growth factor preparation (lyophilized PRP powder) was prepared using 12 pooled platelet concentrates (PCs) derived from different donors via apheresis...
November 30, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27902902/history-of-the-first-generation-marek-s-disease-vaccines-the-science-and-little-known-facts
#2
Karel A Schat
Shortly after the isolation of Marek's disease (MD) herpesvirus (MDV) in the late 1960s vaccines were developed in England, the United States, and The Netherlands. Biggs and associates at the Houghton Poultry Research Station (HPRS) in England attenuated HPRS-16, the first cell-culture-isolated MDV strain, by passaging HPRS-16 in chick kidney cells. Although HPRS-16/Att was the first commercially available vaccine, it never became widely used and was soon replaced by the FC126 strain of herpesvirus of turkeys (HVT) vaccine developed by Witter and associates at the Regional Poultry Research Laboratory (now Avian Disease and Oncology Laboratory [ADOL]) in East Lansing, MI...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27899121/meta-analysis-of-the-clinical-and-laboratory-parameters-of-sfts-patients-in-china
#3
Miao-Miao Liu, Xiao-Ying Lei, Xue-Jie Yu
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever in East Asia, which is caused by a novel bunyavirus-SFTSV. Many studies have reported the clinical characters of SFTS patients, but the reports were not consistent and a systematic summary of clinical manifestations and laboratory parameters are not available. METHOD: A comprehensive literature research of Web of Science, PubMed, Wan Fang Data, and Chinese National Knowledge Infrastructure databases was conducted on articles which have described the clinical characters of SFTS patients...
November 29, 2016: Virology Journal
https://www.readbyqxmd.com/read/27876286/clinical-trials-in-a-dish
#4
David G Strauss, Ksenia Blinova
Clinical trials 'in a dish' involve testing medical therapies for safety or effectiveness in the laboratory with human tissue. This has become possible owing to recent biotechnology advances including induced pluripotent stem cells, organs-on-a-chip, and whole-genome sequencing. We provide here an overview of the landscape and highlight steps the FDA is taking to advance the science of clinical trials in a dish and to support the development and validation of new regulatory paradigms to assess drug safety using these new technologies...
November 19, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27872781/two-invasive-thymomas-incidentally-found-during-coronary-artery-bypass-graft-surgery
#5
Navid Omidifar, Maral Mokhtari, Mansoureh Shokripour
Thymoma, the most common neoplasm of the anterior mediastinum, is a rare tumor of thymic epithelium that can be locally invasive. We reported 2 cases of invasive thymoma incidentally found during routine coronary artery bypass graft (CABG) surgery at Faghihee Hospital of Shiraz University of Medical Sciences of Iran in a period of about 6 months. The 2 patients were male and above 60 years old. They had no clinical symptoms and radiological evidence of mediastinal mass before detection of the tumor during operation...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27870410/sex-differences-in-neuroinflammation-and-neuroprotection-in-ischemic-stroke
#6
REVIEW
Monica S Spychala, Pedram Honarpisheh, Louise D McCullough
Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke-related disability. Stroke has dropped to the fifth leading cause of death in men, but remains the third in women. This review discusses sex differences in common stroke risk factors, the efficacy of stroke prevention therapies, acute treatment responses, and post-stroke recovery in clinical populations...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27866899/potential-of-compact-compton-sources-in-the-medical-field
#7
Marie Jacquet
The exceptional improvement of high power lasers and optical cavity finesses in the last fifteen years allows today the development of X-ray sources based on inverse Compton scattering. These compact sources will provide high intensity beams, with a tunable energy in the range 20-100keV, that can be used in several application including material sciences, structural biology, cultural heritage research and preservation and medical or biomedical preclinical and clinical research. The access to these devices will be easier...
November 17, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27858891/pediatric-visceral-leishmaniasis-in-northwest-of-iran
#8
Babak Abdinia, Mohammad Oliaei-Motlagh, Amir Teimouri-Dereshki
Leishmaniasis is one of the major health problems in Iran. Although the incidence of visceral leishmaniasis (VL) is reported almost everywhere, the northwestern Iran is one of the major endemic regions.To do this study, clinical, laboratory as well as disease characteristics of children admitted to Children Cure and Health Hospital, Tabriz University of Medical Sciences, were examined as the reference hospital for the treatment of VL in northwestern Iran.In this study, 156 children hospitalized in a pediatric hospital from 2000 to 2015 for VL were included...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27856702/therapeutic-drug-monitoring-in-the-past-40-years-of-the-journal-of-antimicrobial-chemotherapy
#9
REVIEW
David Reeves, Andrew Lovering, Alison Thomson
Since the Journal of Antimicrobial Chemotherapy was first published in 1975, papers addressing therapeutic drug monitoring (TDM) have been a regular feature. Initially they focused on laboratory aspects of drug concentration measurement then they changed more to the application of TDM in a clinical setting. Over its history, the Journal has provided its readership with the latest technological and scientific advances in TDM and has helped to drive changes in TDM that have directly impacted on patient care. These have varied from improvement in the quality of antimicrobial measurements through better identification of dosage regimens and TDM targets that help predict outcome and adverse events...
December 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27833652/molecular-detection-of-epstein-barr-virus-in-nasopharyngeal-carcinoma-among-sudanese-population
#10
Ali Edreis, Mona Ali Mohamed, Nouh S Mohamed, Emmanuel E Siddig
BACKGROUND: Nasopharyngeal carcinoma (NPC) is the most common cancer arising from the nasopharynx that varies significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatment. NPC caused by an interaction between infection with EBV and environmental and genetic factors, encompasses a multistep oncogenic process. The frequency of Epstein-Barr virus EBV among nasopharyngeal carcinoma is well known worldwide, however, in the Sudan there is barely a published data...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27829809/bridging-theory-and-practice-mixed-methods-approach-to-instruction-of-law-and-ethics-within-the-pharmaceutical-sciences
#11
Kyle John Wilby, Ziad Ghantous Nasr
Background: Professional responsibilities are guided by laws and ethics that must be introduced and mastered within pharmaceutical sciences training. Instructional design to teaching typically introduces concepts in a traditional didactic approach and requires student memorization prior to application within practice settings. Additionally, many centers rely on best practices from abroad, due to lack of locally published laws and guidance documents. Objectives: The aim of this paper was to summarize and critically evaluate a professional skills laboratory designed to enhance learning through diversity in instructional methods relating to pharmacy law and best practices regarding narcotics, controlled medications, and benzodiazepines...
November 2016: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/27814971/gait-biomechanics-in-the-era-of-data-science
#12
Reed Ferber, Sean T Osis, Jennifer L Hicks, Scott L Delp
Data science has transformed fields such as computer vision and economics. The ability of modern data science methods to extract insights from large, complex, heterogeneous, and noisy datasets is beginning to provide a powerful complement to the traditional approaches of experimental motion capture and biomechanical modeling. The purpose of this article is to provide a perspective on how data science methods can be incorporated into our field to advance our understanding of gait biomechanics and improve treatment planning procedures...
October 27, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27814455/mobile-devices-for-the-remote-acquisition-of-physiological-and-behavioral-biomarkers-in-psychiatric-clinical-research
#13
Zachary W Adams, Erin A McClure, Kevin M Gray, Carla Kmett Danielson, Frank A Treiber, Kenneth J Ruggiero
Psychiatric disorders are linked to a variety of biological, psychological, and contextual causes and consequences. Laboratory studies have elucidated the importance of several key physiological and behavioral biomarkers in the study of psychiatric disorders, but much less is known about the role of these biomarkers in naturalistic settings. These gaps are largely driven by methodological barriers to assessing biomarker data rapidly, reliably, and frequently outside the clinic or laboratory. Mobile health (mHealth) tools offer new opportunities to study relevant biomarkers in concert with other types of data (e...
October 22, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27813068/1-st-embl-dfg-women-in-science-network-conference-heidelberg-2016-from-genes-cells-and-the-immune-system-towards-therapies-meeting-report
#14
Renata Stripecke, Cécile Gouttefangeas, Irmgard Förster
The 1(st) EMBL/DFG Women in Science (WiS) Conference "From Genes, Cells and the Immune System towards Therapies" was held on 19(th) - 20(th) September 2016 in Heidelberg, Germany. The WiS conference was funded by nine Collaborative Research Centers (CRCs) of the German Research Council (Deutsche Forschungsgemeinschaft, DFG; Table 1) and benefited from an outstanding hosting environment at the Advanced Training Center of the European Molecular Biology Laboratory (EMBL). Scientific talks focused at genetic, cellular and immunologic mechanisms, and immune therapy, and progress from all stages of development covering basic research to clinical developments was described...
November 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27807148/a-rose-by-any-other-name-practical-updates-on-microbial-nomenclature-for-clinical-microbiology
#15
EDITORIAL
Colleen S Kraft, Alexander J McAdam, Karen C Carroll
The clinical microbiology laboratory stands at the interface between basic science, including the study of phylogeny, and applications of science in the very practical world of medical care.….
November 2, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27806847/false-positive-results-in-diagnostic-immunohistochemistry-are-related-to-horseradish-peroxidase-conjugates-in-commercially-available-assays
#16
Gerard Nuovo
False-positive results in diagnostic immunopathology can lead to unnecessary treatments. The purpose of this study was to do a side-by-side comparison of 10 different antibodies commonly used in the clinical laboratory altering only the horseradish peroxidase (HRP) conjugate. The automated Leica BOND-MAX platform was used to study serial sections from 203 tissues including controls compared in a blinded fashion using the HRP conjugates from Leica (Refine HRP), Ventana Medical Systems (Ultraview HRP), and Enzo Life Sciences (Polyview HRP)...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27801973/scai-ccas-spa-expert-consensus-statement-for-anesthesia-and-sedation-practice-recommendations-for-patients-undergoing-diagnostic-and-therapeutic-procedures-in-the-pediatric-and-congenital-cardiac-catheterization-laboratory
#17
Kirsten C Odegard, Robert Vincent, Rahul Baijal, SuAnne Daves, Robert Gray, Alex Javois, Barry Love, Phil Moore, David Nykanen, Lori Riegger, Scott G Walker, Elizabeth C Wilson
Current practice of sedation and anesthesia for patients undergoing pediatric congenital cardiac catheterization laboratory (PCCCL) procedures is known to vary among institutions, a multi-society expert panel with representatives from the Congenital Heart Disease Council of the Society for Cardiovascular Angiography and Interventions (SCAI), the Society for Pediatric Anesthesia (SPA) and the Congenital Cardiac Anesthesia Society (CCAS) was convened to evaluate the types of sedation and personnel necessary for procedures performed in the PCCCL...
November 1, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27800290/antibiogram-of-medical-intensive-care-unit-at-tertiary-care-hospital-setting-of-pakistan
#18
Aayesha Qadeer, Aftab Akhtar, Qurat Ul Ain, Shoab Saadat, Salman Mansoor, Salman Assad, Wasib Ishtiaq, Abid Ilyas, Ali Y Khan, Yousaf Ajam
OBJECTIVE:  To determine the frequency of micro-organisms causing sepsis as well as to determine the antibiotic susceptibility and resistance of microorganisms isolated in a medical intensive care unit. MATERIALS AND METHODS:  This is a cross-sectional analysis of 802 patients from a medical intensive care unit (ICU) of Shifa International Hospital, Islamabad, Pakistan over a one-year period from August 2015 to August 2016. Specimens collected were from blood, urine, endotracheal secretions, catheter tips, tissue, pus swabs, cerebrospinal fluid, ascites, bronchoalveolar lavage (BAL), and pleural fluid...
September 29, 2016: Curēus
https://www.readbyqxmd.com/read/27795453/medical-research-in-stalin-s-gulag
#19
Golfo Alexopoulos
Recently declassified Gulag archives reveal for the first time that the Stalinist leadership established medical research laboratories in the camps. The present work offers an initial reading of the medical research conducted by and on prisoners in Stalin's Gulag. Although Gulag science did not apparently possess the lethal character of Nazi medicine, neither was this work entirely benign. I argue that the highly constrained environment of the Stalinist camps distorted medical science. Scientists were forced to produce work agreeable to their Gulag administrators...
2016: Bulletin of the History of Medicine
https://www.readbyqxmd.com/read/27792871/found-in-translation-international-initiatives-pursuing-interleukin-1-blockade-for-treatment-of-acute-kawasaki-disease
#20
REVIEW
Jane C Burns, Isabelle Koné-Paut, Taco Kuijpers, Chisato Shimizu, Adriana Tremoulet, Moshe Arditi
The decision to move forward with three clinical trials of IL-1 blockade for treatment of acute Kawasaki disease is a case study in translational science. These trials were born on the one hand from transcriptome studies of host response during the acute disease coupled with animal model investigations of key immune signaling pathways and, on the other hand, out of clinical desperation to intervene in patients with severe inflammation in the setting of acute Kawasaki disease. The convergence of laboratory science and clinical observations led to the clinical trials described here and serves as a model for how such observations can be translated into new therapies...
October 28, 2016: Arthritis & Rheumatology
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