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Clinical Laboratory Science

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https://www.readbyqxmd.com/read/29777667/properties-and-units-in-the-clinical-laboratory-sciences-part-xxiv-properties-and-units-in-clinical-molecular-genetics-technical-report-2017
#1
Ulla M Petersen, Ariadna Padró Miquel, Graham Taylor, Jens Michael Hertz, Rebecca Ceder, Xavier Fuentes Arderiu, Johan T den Dunnen
This document describes the application of the syntax, semantic rules, and format of the Nomenclature for Properties and Units (NPU) terminology for coded dedicated kinds-of-property in the subject field of clinical molecular genetics. A vocabulary for NPU definitions in this field, based on international terminology and nomenclature, is introduced; examples of actual NPU definitions for different types of investigations are given and explained.
May 16, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29760622/skin-and-mucous-membranes-manifestations-of-dermatological-diseases-within-the-genital-area-in-females
#2
Katarzyna Plagens-Rotman, Renata Przybylska, Zygmunt Adamski, Magdalena Czarnecka-Operacz
Introduction: Lichen sclerosus et atrophicus (LSA) and an inversed type of psoriasis belong to a group of benign dermatoses usually located within the region of female external genitalia. The most common subjective symptoms reported by patients are itching, pain and changes in the color and structure of the skin. Aim: This paper presents 3 cases of patients suffering from selected dermatoses located within the external female genitalia treated at the Department of Dermatology, Poznan University of Medical Sciences...
April 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29759021/alginate-ototoxicity-in-the-mouse-model
#3
Sameer A Alvi, Jennifer Nelson-Brantley, Hinrich Staecker
Objective To determine whether alginate exposure to the round window of the mouse causes any measurable ototoxicity. Study Design Prospective animal study. Setting Basic science laboratory affiliated with a tertiary care university medical center. Subjects and Methods After Institutional Animal Care and Use Committee approval, 5 adult mice were obtained and underwent bullostomy and round window niche application of alginate. Auditory brainstem response (ABR) tests were completed at baseline prior to the procedure and also 5, 14, and 30 days postprocedure...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29758979/developmental-screening-tool-accuracy-and-feasibility-of-non-invasive-anaemia-estimation
#4
Raja Muthalagu, Vijayan Thulasi Bai, Doreen Gracias, Sheila John
Anaemia is predicted as one of the serious communal health issue in the world. The deficiency exists most common among children and women. A substantial issue prevails in providing quality healthcare services to rural communities, which remains a challenge to health service providers throughout the world. Traditionally physician and health workers recognized anaemia from certain clinical findings, such as pallor of the conjunctivae, nail beds, lips, tongue, and oral mucosa. Confirmation of anaemic condition through physical examination of Dorsum of a tongue or lower bulbar conjunctiva is a subjective analysis...
April 30, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29757036/determinants-of-antibiotics-prescribing-among-doctors-in-a-nigerian-urban-tertiary-hospital
#5
Olayinka O Ogunleye, Joseph O Fadare, Adesola F Yinka-Ogunleye, Bene D Anand Paramadhas, Brian Godman
BACKGROUND AND OBJECTIVE: The problem of antimicrobial resistance (AMR) has assumed pandemic dimensions especially among low and middle-income countries such as Nigeria. Irrational use of currently available antimicrobial agents is a major contributory factor. There remains a paucity of documented information on the determinants of antibiotics prescribing among physicians in Nigeria to guide future strategies to reduce AMR. This study therefore aimed to investigate the patterns and determinants of antibiotics prescription among doctors in a tertiary hospital in Nigeria as the first step to improve future antibiotic use in hospitals...
May 14, 2018: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/29754856/three-dimensional-dental-and-craniofacial-manifestations-in-patients-with-late-diagnosis-of-mucopolysaccharidosis-type-ii-report-of-2-cases
#6
Rafaela de Oliveira Torres, Andréa Vaz Braga Pintor, Fábio Ribeiro Guedes, Lucia Helena Soares Cevidanes, Liana Bastos Freitas-Fernandes, Antônio Carlos de Oliveira Ruellas, Ivete Pomarico Ribeiro de Souza
The objective of this study was to report the clinical evaluation results and 3-dimensional (3-D) dental and craniofacial characteristics observed in 2 male patients with mucopolysaccharidosis type II. The patients were evaluated clinically (soft tissue evaluation, evaluation of occlusion, periodontal and dental examinations) and by using craniofacial computed tomography, with evaluation of 3-D images in ITK-Snap v. 2.2 (Penn Image Computing and Science Laboratory, Philadelphia, PA; http://www.itksnap.org/) and 3-D Slicer (http://www...
April 16, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29737452/comparison-of-clinical-features-and-prognostic-factors-of-cryptococcal-meningitis-caused-by-cryptococcus-neoformans-in-patients-with-and-without-pulmonary-nodules
#7
Wenhao Cao, Cui Jian, Huojun Zhang, Shuyun Xu
Whether the clinical features of cryptococcal meningitis (CM) patients vary with the coexistence of pulmonary nodules is not clear. This study aimed to compare the clinical features of CM in patients with and without pulmonary nodules detected by chest computed tomography (CT). The medical records of CM patients hospitalized in Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 1, 2010, to December 31, 2016, were retrospectively reviewed. Baseline demographics, laboratory and radiographic findings, clinical managements, and outcomes were analyzed...
May 8, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29727369/blue-light-enhances-bacterial-clearance-and-reduces-organ-injury-during-sepsis
#8
Anthony J Lewis, Xianghong Zhang, John E Griepentrog, Du Yuan, Richard D Collage, Paul K Waltz, Derek C Angus, Brian S Zuckerbraun, Matthew R Rosengart
OBJECTIVES: The physiology of nearly all mammalian organisms are entrained by light and exhibit circadian rhythm. The data derived from animal studies show that light influences immunity, and these neurophysiologic pathways are maximally entrained by the blue spectrum. Here, we hypothesize that bright blue light reduces acute kidney injury by comparison with either bright red or standard, white fluorescent light in mice subjected to sepsis. To further translational relevance, we performed a pilot clinical trial of blue light therapy in human subjects with appendicitis...
May 4, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29722979/rptag-as-an-orally-bioavailable-hyperstable-epitope-tag-and-generalizable-protein-binding-scaffold
#9
Jennifer R DeRosa, Brandon S Moyer, Ellie Lumen, Aaron J Wolfe, Meegan B Sleeper, Anthony H Bianchi, Ashleigh Crawford, Connor McGuigan, Danique Wortel, Cheyanne Fisher, Kelsey J Moody, Adam R Blanden
Antibodies are the most prolific biologics in research and clinical environments because of their ability to bind targets with high affinity and specificity. However, antibodies also carry liabilities. A significant portion of the life science reproducibility crisis is driven by inconsistent performance of research-grade antibodies, and clinical antibodies are often unstable and require costly cold chain management to reach their destinations in active form. In biotechnology, antibodies are also limited by difficulty integrating them in many recombinant systems due to their size and structural complexity...
May 3, 2018: Biochemistry
https://www.readbyqxmd.com/read/29720009/interprofessional-learning-experiences-exploring-the-perception-and-attitudes-of-saudi-arabian-medical-and-dental-students
#10
Ghadeer K Al-Shaikh, Ebtissam M Al-Madi, Jazba Masood, Quratulain Shaikh, Sadiqa B Syed, Rima S Bader, Judy McKimm
OBJECTIVE: The objective of this study is to evaluate the awareness and attitudes of medical and dental students regarding interprofessional learning (IPL). METHODS: A cross-sectional study was conducted with 278 female undergraduate Medical and Dental students from Princess Nourah bint Abdulrahman University, Riyadh. These students undertook IPL in the Foundation block, in basic science teaching, clinical skills' laboratories and in professionalism and learning skills' modules...
May 2, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29719842/acute-appendicitis-during-pregnancy-results-of-a-cohort-study-in-a-single-iranian-center
#11
Somaye Bazdar, Maryam Dehghankhalili, Shekoofeh Yaghmaei, Maryam Azadegan, Amirhossein Pourdavood, Mohammad Hadi Niakan, Ali Mohammad Bananzadeh
Objective: To determine the effects of pregnancy on the presentation, management, surgical and obstetrics outcome of patients with acute appendicitis. Methods: This prospective cohort study was conducted during a 2-year period from 2014 to 2016 in Shahid Faghihi hospital of Shiraz University of Medical Sciences. We enrolled all the pregnant individuals with acute appendicitis who required surgical appendectomy. We also enrolled age-matched controls of non-pregnant women undergoing open appendectomy during the study period...
April 2018: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/29713492/effect-of-cold-stress-on-infanticide-by-female-swiss-albino-mice-mus-musculus-a-pilot-study
#12
Tabassum Zafar, Ab Qayoom Naik, Vinoy K Shrivastava
Background: Mice are widely accepted research models of great clinical significance. Maintenance of laboratory mice breed is an essential aspect for performing research activities in various fields of science. Infanticide is one of the prominent causes of litter loss during maintenance of laboratory mice stock. The present study is an effort to monitor the effect of change in ambient temperature of female mice below the normal range on cannibalism and infanticide during early postparturition phase...
2018: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/29706132/when-complexity-science-meets-implementation-science-a-theoretical-and-empirical-analysis-of-systems-change
#13
Jeffrey Braithwaite, Kate Churruca, Janet C Long, Louise A Ellis, Jessica Herkes
BACKGROUND: Implementation science has a core aim - to get evidence into practice. Early in the evidence-based medicine movement, this task was construed in linear terms, wherein the knowledge pipeline moved from evidence created in the laboratory through to clinical trials and, finally, via new tests, drugs, equipment, or procedures, into clinical practice. We now know that this straight-line thinking was naïve at best, and little more than an idealization, with multiple fractures appearing in the pipeline...
April 30, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29691928/circadian-rhythms-refractive-development-and-myopia
#14
Ranjay Chakraborty, Lisa A Ostrin, Debora L Nickla, P Michael Iuvone, Machelle T Pardue, Richard A Stone
PURPOSE: Despite extensive research, mechanisms regulating postnatal eye growth and those responsible for ametropias are poorly understood. With the marked recent increases in myopia prevalence, robust and biologically-based clinical therapies to normalize refractive development in childhood are needed. Here, we review classic and contemporary literature about how circadian biology might provide clues to develop a framework to improve the understanding of myopia etiology, and possibly lead to rational approaches to ameliorate refractive errors developing in children...
May 2018: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/29680422/effect-of-kidney-transplantation-on-sleep-disordered-breathing-in-patients-with-end-stage-renal-disease-a-polysomnographic-study
#15
Sanjiv Mahajan, Kartik Gupta, Sanjeev Sinha, Atul Malhotra, Sandeep Mahajan
BACKGROUND: Sleep-disordered breathing (SDB) is common in patients with end-stage renal disease (ESRD). SDB is associated with comorbidities such as hypertension, diabetes mellitus, and obesity, interplaying with metabolic derangements in the form of uremia, acidosis, and hypervolemia. Renal transplant has been observed to correct most of these metabolic derangements and to control progression of comorbidities. While SDB is highly prevalent among patients in the pretransplant stage, it remains to be seen whether the beneficial aspects of transplant are extended to improvement in SDB in patients with ESRD...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29658444/development-of-225ac-radiopharmaceuticals-triumf-perspectives-and-experiences
#16
A Kh Robertson, C F Ramogida, P Schaffer, V Radchenko
The development of radiopharmaceuticals containing 225Ac for targeted alpha therapy is an active area of academic and commercial research worldwide. Despite promising results from recent clinical trials, 225Ac-radiopharmaceutical development still faces significant challenges that must be overcome to realize the widespread clinical use of 225Ac. Some of these challenges include the limited availability of the isotope, the challenging chemistry required to isolate 225Ac from any co-produced isotopes, and the need for stable targeting systems with high radiolabeling yields...
April 16, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29657197/adamts-13-level-in-children-with-severe-diarrhea-associated-hemolytic-uremic-syndrome-unmasking-new-association
#17
Naglaa A Khalifa, Heba H Gawish, Noora A Khalifa, Doaa M Tawfeek, Saed M Morsy
Severe deficiency of ADAMTS-13 leads to thrombotic thrombocytopenic purpura. Few studies have reported reduced activity of ADAMTS-13 in patients with atypical and typical hemolytic uremic syndrome (HUS). We hypothesized that ADAMTS-13 deficiency might play a role in the pathogenesis of severe HUS. This study aimed to evaluate the ADAMTS-13 level in severe typical HUS. This prospective case-control study was carried out in the Pediatric Nephrology Unit and Clinical Pathology Department, Faculty of Medicine, Zagazig University from February 2013 to February 2014...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29656563/factors-affecting-publication-in-peer-reviewed-journals-of-abstracts-presented-from-2008-to-2012-acvo-meetings
#18
Ellison Bentley, Megan Koester, Tali Bdolah-Abram, Nadav Yair, Ron Ofri
PURPOSE: To examine variables that affect publication of ACVO meeting abstracts in peer-reviewed journals and compare results to ECVO publication rate (PR). METHODS: Published papers were identified via online searches for abstracts from 2008 to 2012 ACVO/ECVO meetings. Variables analyzed (via Pearson's chi-Squared test) included the following: oral presentation/poster, type of abstract (clinical/basic science/case report), species, ocular tissue, nationality, funding, first/last/any author a diplomate, resident as first author, and author affiliation (private practice/university)...
April 14, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29650544/evaluation-and-management-of-right-sided-heart-failure-a-scientific-statement-from-the-american-heart-association
#19
REVIEW
Marvin A Konstam, Michael S Kiernan, Daniel Bernstein, Biykem Bozkurt, Miriam Jacob, Navin K Kapur, Robb D Kociol, Eldrin F Lewis, Mandeep R Mehra, Francis D Pagani, Amish N Raval, Carey Ward
BACKGROUND AND PURPOSE: The diverse causes of right-sided heart failure (RHF) include, among others, primary cardiomyopathies with right ventricular (RV) involvement, RV ischemia and infarction, volume loading caused by cardiac lesions associated with congenital heart disease and valvular pathologies, and pressure loading resulting from pulmonic stenosis or pulmonary hypertension from a variety of causes, including left-sided heart disease. Progressive RV dysfunction in these disease states is associated with increased morbidity and mortality...
May 15, 2018: Circulation
https://www.readbyqxmd.com/read/29619894/analysis-of-laboratory-and-benchtop-performance-of-a-mealtime-insulin-delivery-system
#20
Eric Zijlstra
In the current issue of Journal of Diabetes Science and Technology, Dreon et al give a comprehensive overview of the technical performance of a wearable patch for bolus insulin delivery. The test results generated by the manufacturer of the bolus-patch provide the technical prerequisites for clinical application. As the device received FDA clearance already in 2010, positive results from the nonclinical performance testing were to be expected, but present nevertheless interesting insights into the device development...
April 1, 2018: Journal of Diabetes Science and Technology
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