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https://www.readbyqxmd.com/read/29168222/the-prognostic-significance-of-frailty-compared-to-peak-oxygen-consumption-and-b-type-natriuretic-peptide-in-patients-with-advanced-heart-failure
#1
Yasbanoo Moayedi, Juan G Duero Posada, Farid Foroutan, Livia A Goldraich, Ana C Alba, Jane MacIver, Heather J Ross
Frailty assessment has become an integral part of the evaluation of potential candidates for heart transplantation and ventricular assist device (HTx/VAD). The impact of frailty, as a heart failure risk factor or to identify those who will derive the greatest benefit with HTx/VAD remains unclear. The aim of this study was to evaluate the independent prognostic relevance of frailty assessment from peak oxygen consumption (peak VO2 ) or B-type natriuretic peptide (BNP) on mortality in patients referred for advanced heart failure therapies...
November 23, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29168008/gabaa-receptor-subunit-deregulation-in-the-hippocampus-of-human-foetuses-with-down-syndrome
#2
Ivan Milenkovic, Tamara Stojanovic, Eleonora Aronica, Livia Fülöp, Zsolt Bozsó, Zoltán Máté, Yuchio Yanagawa, Homa Adle-Biassette, Gert Lubec, Gábor Szabó, Tibor Harkany, Gábor G Kovács, Erik Keimpema
The function, regulation and cellular distribution of GABAA receptor subunits have been extensively documented in the adult rodent brain and are linked to numerous neurological disorders. However, there is a surprising lack of knowledge on the cellular (sub-) distribution of GABAA receptor subunits and of their expressional regulation in developing healthy and diseased foetal human brains. To propose a role for GABAA receptor subunits in neurodevelopmental disorders, we studied the developing hippocampus of normal and Down syndrome foetuses...
November 22, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29166878/the-andromeda-prospective-cohort-study-predictive-value-of-combined-criteria-to-tailor-breast-cancer-screening-and-new-opportunities-from-circulating-markers-study-protocol
#3
Livia Giordano, Federica Gallo, Elisabetta Petracci, Giovanna Chiorino, Nereo Segnan
BACKGROUND: In recent years growing interest has been posed on alternative ways to screen women for breast cancer involving different imaging techniques or adjusting screening interval by breast cancer risk estimates. A new research area is studying circulating microRNAs as molecular biomarkers potentially useful for non invasive early detection together with the analysis of single-nucleotide polymorphisms (SNPs). The Andromeda study is a prospective cohort study on women attending breast cancer screening in a northern Italian area...
November 22, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29166538/antimicrobial-photodynamic-therapy-associated-with-conventional-endodontic-treatment-a-clinical-and-molecular-microbiological-study
#4
Caroline C da Silva, Sérgio P Chaves Júnior, Gabriela L D Pereira, Karla B F C da Fontes, Lívia A A Antunes, Helvécio C C Póvoa, Leonardo S Antunes, Natalia L P Póvoa Iorio
This study evaluated antimicrobial photodynamic therapy (aPDT) as an adjunct to endodontic treatment. Ten uniradicular teeth (control group (CG)= 4 (2 and test group (TG)= 6) with primary endodontic infections, from both genders, between 17 and 65 years old, were analyzed. Microbiological samples were collected before and after chemical-mechanical instrumentation (CMI), after aPDT (for the TG), and after the removal of the temporary restorations (second session). In TG, the aPDT was performed with 100 μg/mL methylene blue and irradiated with low power laser (InGaAIP, 660 nm; 100 mW; 40 sec) with a fiber-coupled optical laser...
November 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29166466/neurological-complications-of-solid-organ-transplantation
#5
José Luiz Pedroso, Lívia Almeida Dutra, Pedro Braga-Neto, Agessandro Abrahao, João Brainer Clares de Andrade, Gabriel Lopes da Silva, Laila Almeida Viana, José Osmar Medina Pestana, Orlando G Barsottini
Solid organ transplantation is a significant development in the treatment of chronic kidney, liver, heart and lung diseases. This therapeutic approach has increased patient survival and improved quality of life. New surgical techniques and immunosuppressive drugs have been developed to achieve better outcomes. However, the variety of neurological complications following solid organ transplantation is broad and carries prognostic significance. Patients may have involvement of the central or peripheral nervous system due to multiple causes that can vary depending on time of onset after the surgical procedure, the transplanted organ, and the intensity and type of immunosuppressive therapy...
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29157336/dissociated-components-of-executive-control-in-acute-hypobaric-hypoxia
#6
Endre Takács, István Czigler, Lívia Gabriella Pató, László Balázs
INTRODUCTION: The neurocognitive effects of acute hypobaric hypoxia are still largely unknown. This study was designed to test the hypothesis that executive control, an important component of cognition, is especially vulnerable to hypoxia. METHODS: Subjects participated in a simulated hypobaric chamber flight to 5500 m. Four auditory tasks were presented before, during, and after hypoxia: 1) Voice, and 2) Name variant of the Stroop task (both measuring conflict resolution); 3) go/no-go task (GNG; measuring inhibition); and 4) two-choice reaction time task (CRT; which is a noninhibitory control task)...
December 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29156571/studies-for-improving-a-rat-model-of-alzheimer-s-disease-icv-administration-of-well-characterized-%C3%AE-amyloid-1-42-oligomers-induce-dysfunction-in-spatial-memory
#7
Ágnes Kasza, Botond Penke, Zsuzsanna Frank, Zsolt Bozsó, Viktor Szegedi, Ákos Hunya, Klaudia Németh, Gábor Kozma, Lívia Fülöp
During the past 15 years, several genetically altered mouse models of human Alzheimer's disease (AD) have been developed. These costly models have greatly facilitated the evaluation of novel therapeutic approaches. Injecting synthetic β-amyloid (Aβ) 1-42 species into different parts of the brain of non-transgenic rodents frequently provided unreliable results, owing to a lack of a genuine characterization of the administered Aβ aggregates. Previously, we have published a new rat AD-model in which protofibrillar-fibrillar Aβ1-42 was administered into rat entorhinal cortex (Sipos 2007)...
November 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29152818/electrical-stimulation-of-dorsal-root-ganglion-in-the-context-of-pain-a-systematic-review-of-in-vitro-and-in-vivo-animal-model-studies
#8
REVIEW
Ivana Vuka, Katarina Vučić, Tihana Repić, Lejla Ferhatović Hamzić, Damir Sapunar, Livia Puljak
OBJECTIVE: Dorsal root ganglion (DRG) has recently emerged as an attractive target for neuromodulation therapy since primary sensory neurons and their soma in DRGs are important sites for pathophysiologic changes that lead to neuropathic pain. Our aim was to create evidence synthesis about the effects of electrical stimulation of DRG in the context of pain from in vitro and in vivo animal models, analyze methodology and quality of studies in the field. METHODS: For conducting systematic review we searched three data bases: MEDLINE, Embase and Web of Science...
November 20, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29152707/ethylene-glycol-toxicity-a-retrospective-pathological-study-in-cats
#9
Livia Amoroso, Cristiano Cocumelli, Giampaolo Bruni, Alberto Brozzi, Francesco Tancredi, Goffredo Grifoni, Antonio Mastromattei, Roberta Meoli, Giovanni Di Guardo, Claudia Eleni
Ethylene glycol (EG) is a well known toxic compound, the assumption of which can be fatal to pet animals as well as to humans. Limited information is available on the pathological features of EG poisoning in pet animals, with special emphasis on cats. Twenty-five cats with histologically confirmed EG intoxication were retrospectively investigated, in order to define more precisely the gross pathological findings and improve the diagnostic process. Furthermore, a brief comparison with the lesions reported in EG-poisoned human patients and dogs was also made...
September 30, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/29152120/hierarchical-clustering-analysis-identifies-metastatic-colorectal-cancers-patients-with-more-aggressive-phenotype
#10
Giuseppina Opinto, Nicola Silvestris, Matteo Centonze, Giusi Graziano, Rosamaria Pinto, Livia Fucci, Giovanni Simone, Anita Mangia
A large percentage of metastatic colorectal cancer (mCRC) patients presents metastasis at the time of diagnosis. In the last years, great efforts have been made in the treatment of these patients with the identification of different phenotypes playing a key role in the definition of new systemic therapies. Unsupervised hierarchical clustering analysis (HCA) was performed considering the clinicopathological characteristics of 51 mCRCs. Using immunohistochemistry on tissue microarrays, we assessed the expression of β-catenin, NHERF1, RASSF1A, TWIST1, HIF-1α proteins in tumors and paired liver metastases...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151842/a-do-it-yourself-phenotyping-system-measuring-growth-and-morphology-throughout-the-diel-cycle-in-rosette-shaped-plants
#11
Andrei Dobrescu, Livia C T Scorza, Sotirios A Tsaftaris, Alistair J McCormick
Background: Improvements in high-throughput phenotyping technologies are rapidly expanding the scope and capacity of plant biology studies to measure growth traits. Nevertheless, the costs of commercial phenotyping equipment and infrastructure remain prohibitively expensive for wide-scale uptake, while academic solutions can require significant local expertise. Here we present a low-cost methodology for plant biologists to build their own phenotyping system for quantifying growth rates and phenotypic characteristics of Arabidopsis thaliana rosettes throughout the diel cycle...
2017: Plant Methods
https://www.readbyqxmd.com/read/29151006/the-practical-update-for-family-physicians-in-the-diagnosis-and-management-of-overactive-bladder-and-lower-urinary-tract-symptoms
#12
Jack Barkin, Jeffrey Habert, Amy Wong, Livia Y T Lee
OBJECTIVE: To provide family physicians with an up-to-date, practical overview of the diagnosis and management of overactive bladder (OAB) alone or with bladder outlet obstruction. MAIN MESSAGE: OAB is urinary urgency with or without incontinence, often accompanied by frequency and nocturia, in the absence of urinary tract infection and can affect both men and women. Men often have co-existing OAB associated with bladder outlet obstruction, and benign prostatic hyperplasia...
October 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29150580/odontogenic-abscesses-in-pet-rabbits
#13
Livia Benato
No abstract text is available yet for this article.
November 18, 2017: Veterinary Record
https://www.readbyqxmd.com/read/29149538/psychologic-intimate-partner-violence-and-the-risk-of-intrauterine-growth-restriction-in-rio-de-janeiro
#14
Gustavo Lobato, Michael E Reichenheim, Claudia L Moraes, Fernando M Peixoto-Filho, Lívia S Migowski
OBJECTIVE: To evaluate whether psychologic intimate partner violence (IPV) during pregnancy is a risk factor for intrauterine growth restriction (IUGR). METHODS: The cross-sectional study enrolled 810 randomly selected mothers of infants younger than 5 months attending basic health services in Rio de Janeiro, Brazil, from January to July 2007. Psychologic and physical IPV were evaluated by the Revised Conflict Tactics Scale; IUGR was defined as below the 10th percentile of the Alexander curve...
November 17, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29147593/rapidly-progressive-disseminated-sporotrichosis-as-the-first-presentation-of-hiv-infection-in-a-patient-with-a-very-low-cd4-cell-count
#15
Isis Cristine Morávia Ribeiro de Oliveira-Esteves, Guilherme Almeida Rosa da Silva, Walter de Araujo Eyer-Silva, Rodrigo Panno Basílio-de-Oliveira, Luciana Ferreira de Araujo, Carlos José Martins, Rogério Neves-Motta, Marcelo Costa Velho Mendes de Azevedo, Dario José Hart Pontes Signorini, Jorge Francisco da Cunha Pinto, Lívia Machado Moura, Rafael Jacyntho Laterça, Diogo Raphael Garcia de Oliveira Pereira, Isabela Vieira do Lago, Fernando Raphael de Almeida Ferry
Sporotrichosis is a human and animal disease caused by species of the Sporothrix schenckii complex. It is classically acquired through traumatic inoculation of fungal elements. Most frequently, sporotrichosis presents as a fixed cutaneous or as a lymphocutaneous form. A much smaller number of cases occur as cutaneous disseminated and disseminated forms. These cases require immediate diagnosis and management to reduce morbidity and mortality. We present the case of a 34-year-old male patient in whom the first presentation of HIV infection was a rapidly progressive sporotrichosis with multiple cutaneous lesions, a high fungal burden in tissues, and pulmonary involvement...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29142880/comparison-of-apical-extrusion-of-intracanal-bacteria-by-various-glide-path-establishing-systems-an-in-vitro-study
#16
Alberto Dagna, Rashid El Abed, Sameeha Hussain, Ibrahim H Abu-Tahun, Livia Visai, Federico Bertoglio, Floriana Bosco, Riccardo Beltrami, Claudio Poggio, Hyeon-Cheol Kim
Objectives: This study compared the amount of apically extruded bacteria during the glide-path preparation by using multi-file and single-file glide-path establishing nickel-titanium (NiTi) rotary systems. Materials and Methods: Sixty mandibular first molar teeth were used to prepare the test apparatus. They were decoronated, blocked into glass vials, sterilized in ethylene oxide gas, infected with a pure culture of Enterococcus faecalis, randomly assigned to 5 experimental groups, and then prepared using manual stainless-steel files (group KF) and glide-path establishing NiTi rotary files (group PF with PathFiles, group GF with G-Files, group PG with ProGlider, and group OG with One G)...
November 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/29141548/cognitive-training-in-patients-with-alzheimer-s-disease-findings-of-a-12-month-randomized-controlled-trial
#17
Alessandro Trebbastoni, Letizia Imbriano, Livia Podda, Lidia Rendace, Maria Luisa Sacchetti, Alessandra Campanelli, Fabrizia D Antonio, Carlo de Lena
BACKGROUND: Cognitive training (CT) is a non-pharmacological intervention based on a set of tasks that reflect specific cognitive functions. CT is aimed at improving cognition in patients with cognitive impairment, though no definitive conclusions have yet been drawn on its efficacy in Alzheimer's disease (AD). OBJECTIVE: To assess the effectiveness of a CT program designed to improve cognition in AD patients. METHOD: This is a randomized, controlled, single-blind, longitudinal trial with a no-treatment control condition in mild-to-moderate AD...
November 12, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29140482/estimating-autoantibody-signatures-to-detect-autoimmune-disease-patient-subsets
#18
Zhenke Wu, Livia Casciola-Rosen, Ami A Shah, Antony Rosen, Scott L Zeger
Autoimmune diseases are characterized by highly specific immune responses against molecules in self-tissues. Different autoimmune diseases are characterized by distinct immune responses, making autoantibodies useful for diagnosis and prediction. In many diseases, the targets of autoantibodies are incompletely defined. Although the technologies for autoantibody discovery have advanced dramatically over the past decade, each of these techniques generates hundreds of possibilities, which are onerous and expensive to validate...
November 13, 2017: Biostatistics
https://www.readbyqxmd.com/read/29139001/the-assessment-for-disinvestment-of-intramuscular-interferon-beta-for-relapsing-remitting-multiple-sclerosis-in-brazil
#19
REVIEW
Livia Lovato Pires de Lemos, Augusto Afonso Guerra Júnior, Marisa Santos, Carlos Magliano, Isabela Diniz, Kathiaja Souza, Ramon Gonçalves Pereira, Juliana Alvares, Brian Godman, Marion Bennie, Ivan Ricardo Zimmermann, Vânia Crisitna Canuto Dos Santos, Clarice Alegre Pretramale, Francisco de Assis Acurcio
In Brazil, inclusion and exclusion of health technologies within the Unified Health System (SUS) is the responsibility of the National Committee for Health Technology Incorporation (CONITEC). A recent Cochrane systematic review demonstrated that intramuscular interferon beta 1a (IFN-β-1a-IM) was inferior to the other beta interferons (IFN-βs) for multiple sclerosis (MS). As a result, CONITEC commissioned an analysis to review possible disinvestment within SUS. The objective of this paper is to describe the disinvestment process for IFN-β-1a-IM in Brazil...
November 14, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29137821/equination-inoculation-of-horsepox-an-early-alternative-to-vaccination-inoculation-of-cowpox-and-the-potential-role-of-horsepox-virus-in-the-origin-of-the-smallpox-vaccine
#20
REVIEW
José Esparza, Livia Schrick, Clarissa R Damaso, Andreas Nitsche
For almost 150 years after Edward Jenner had published the "Inquiry" in 1798, it was generally assumed that the cowpox virus was the vaccine against smallpox. It was not until 1939 when it was shown that vaccinia, the smallpox vaccine virus, was serologically related but different from the cowpox virus. In the absence of a known natural host, vaccinia has been considered to be a laboratory virus that may have originated from mutational or recombinational events involving cowpox virus, variola viruses or some unknown ancestral Orthopoxvirus...
November 11, 2017: Vaccine
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