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https://www.readbyqxmd.com/read/29739755/erv1-chemr23-signaling-protects-from-atherosclerosis-by-modifying-oxldl-uptake-and-phagocytosis-in-macrophages
#1
Andres Laguna-Fernandez, Antonio Checa, Miguel Carracedo, Gonzalo Artiach, Marcelo H Petri, Roland Baumgartner, Maria J Forteza, Xintong Jiang, Teodora Andonova, Mary E Walker, Jesmond Dalli, Hildur Arnardottir, Anton Gisterå, Silke Thul, Craig E Wheelock, Gabrielle Paulsson-Berne, Daniel F J Ketelhuth, Göran K Hansson, Magnus Bäck
Background -In addition to enhanced pro-inflammatory signaling, impaired resolution of vascular inflammation plays a key role in atherosclerosis. Pro-resolving lipid mediators formed through the 12/15 lipoxygenase pathways exert protective effects against murine atherosclerosis. n-3 polyunsaturated fatty acids, including eicosapentaenoic acid (EPA), serve as the substrate for the formation of lipid mediators, which transduce potent anti-inflammatory and pro-resolving actions through their cognate G-protein-coupled receptors...
May 8, 2018: Circulation
https://www.readbyqxmd.com/read/29672038/short-total-synthesis-of-15n5-cylindrospermopsins-from-15nh4cl-enables-precise-quantification-of-freshwater-cyanobacterial-contamination
#2
Artur K Mailyan, Joanna L Chen, Weiwei Li, Arturo A Keller, Shawn Sternisha, Brian G Miller, Armen Zakarian
Fresh water cyanobacterial algal blooms represent a major health risk because these organisms produce cylindrospermopsin, a toxic, structurally complex, zwitterionic uracil-guanidine alkaloid recognized by the EPA as a dangerous drinking water contaminant. At present, the ability to detect and quantify the presence of cylindrospermospin in water samples is severely hampered by the lack of an isotopically-labeled standard for analytical mass spectrometry. Herein, we present a concise, scaled total synthesis of 15N cylindrospermosin from 15N ammonium chloride, which leverages a unique stereoselective intramolecular double conjugate addition step to assemble the tricyclic guanidine core...
April 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29625094/conceptual-underpinnings-of-the-quality-of-life-in-neurological-disorders-neuro-qol-comparisons-of-core-sets-for-stroke-multiple-sclerosis-spinal-cord-injury-and-traumatic-brain-injury
#3
Alex W K Wong, Stephen C L Lau, Mandy W M Fong, David Cella, Jin-Shei Lai, Allen W Heinemann
OBJECTIVE: To determine the extent to which the content of the Quality of Life in Neurological Disorders (Neuro-QoL) covers the International Classification of Functioning, Disability and Health (ICF) Core Sets for multiple sclerosis (MS), stroke, spinal cord injury (SCI), and traumatic brain injury (TBI) using summary linkage indicators. DESIGN: Content analysis by linking content of the Neuro-QoL to corresponding ICF codes of each Core Set for MS, stroke, SCI, and TBI...
April 3, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29609893/evaluation-of-the-characteristics-of-a-workplace-assessment-form-to-assess-entrustable-professional-activities-epas-in-an-undergraduate-surgery-core-clerkship
#4
Vernon R Curran, Diana Deacon, Henry Schulz, Katherine Stringer, Craig N Stone, Norah Duggan, Heidi Coombs-Thorne
OBJECTIVE: Entrustable Professional Activities (EPAs) are explicit, directly observable tasks requiring the demonstration of specific knowledge, skills, and behaviors that learners are expected to perform without direct supervision once they have gained sufficient competence. Undergraduate level implementation of EPAs is relatively new. We examined the characteristics of a workplace assessment form (clinic card) as part of a formative programmatic assessment process of EPAs for a core undergraduate surgery rotation...
March 30, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29582059/assessment-considerations-for-core-entrustable-professional-activities-for-entering-residency
#5
Machelle Linsenmeyer, Leslie Wimsatt, Mark Speicher, James Powers, Stephen Miller, Emmanuel Katsaros
Context: In the process of analyzing entrustable professional activities (EPAs) for use in medical education, ten Cate and others identified challenges, including the need for valid and reliable EPA assessment strategies. Objective: To provide osteopathic medical schools with a database of assessment tools compiled from the literature to assist them with the development and implementation of robust, evidence-based assessment methods. Methods: MEDLINE, ERIC, PubMed, and other relevant databases were searched using MeSH keywords for articles outlining robust, evidence-based assessment tools that could be used in designing assessments for EPAs 1 through 6...
April 1, 2018: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29535206/a-comparison-of-resident-self-perception-and-pediatric-hospitalist-perceptions-of-the-supervisory-needs-of-new-interns
#6
Ariel S Winn, Carolyn H Marcus, Theodore C Sectish, Kathryn Williams, Christopher P Landrigan
OBJECTIVES: The Association of American Medical Colleges published a list of entrustable professional activities (EPAs) that graduating medical students should be able to perform on day 1 of residency without direct supervision. We sought to explore the perceptions of residents and pediatric hospitalists about the level of supervision new interns need in conducting these EPAs. METHODS: An electronic survey was sent to pediatric hospitalists who supervise interns in a large pediatric residency program in which they were asked to rate the amount of supervision they perceive new interns need when performing 11 EPAs...
April 2018: Hospital Pediatrics
https://www.readbyqxmd.com/read/29519189/trusting-early-learners-with-critical-professional-activities-through-emergency-medical-technician-certification
#7
Judith Brenner, Jeffrey Bird, Samara B Ginzburg, Thomas Kwiatkowski, Vincent Papasodero, William Rennie, Elisabeth Schlegel, Olle Ten Cate, Joanne M Willey
BACKGROUND: Two dominant themes face medical education: developing integrated curricula and improving the undergraduate medical education (UME) to graduate medical education (GME) transition. An innovative solution to both of these challenges at the Zucker School of Medicine has been the application of the cognitive apprenticeship framework in requiring emergency medical technician (EMT) certification during the first course in medical school as the core on which to build an integrated curriculum and provide entrustable clinical skills...
March 8, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29468913/the-epa-based-utrecht-undergraduate-clinical-curriculum-development-and-implementation
#8
Olle Ten Cate, Lysanne Graafmans, Indra Posthumus, Lisanne Welink, Marijke van Dijk
AIM: As reports of the application of entrustable professional activities (EPAs) increase, not only for postgraduate but also for undergraduate medical education, there is a need for descriptions of what a UME curriculum with EPAs could look like. We provide such a description based on the experiences at University Medical Center Utrecht, the Netherlands, which can be used as an example by other curriculum developers. METHODS: In a three-year process, the UMC Utrecht Curriculum Committee developed a clinical workplace curriculum with an EPA structure, taking into account examples, such as the US Core EPAs for Entering Residency, and recommendations to integrate and increase the length of clerkships...
February 22, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29438933/assessment-of-cr-pollution-in-tributary-sediment-cores-in-the-three-gorges-reservoir-combining-geochemical-baseline-and-in-situ-dgt
#9
Bo Gao, Li Gao, Dongyu Xu, Yang Zhou, Jin Lu
The mobility and transfer of trace metals in sediments are vital to understanding trace metals environmental behavior in water environment. However, as a predominant aquatic carcinogen, an effective method for assessing the release and deposition for Cr at the sediment-water interface (SWI) is still not clearly understood. Here we established a comprehensive methodology to evaluate the release risk of Cr at the SWI combining regional geochemical baseline (RGB) and diffusive gradients in thin films (DGT). Sediment cores and water samples were collected in the two tributaries and mainstream of the Three Gorges Reservoir, which is the world's largest man-made hydroelectric station...
July 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29355517/eicosapentaenoic-acid-and-docosahexaenoic-acid-have-distinct-membrane-locations-and-lipid-interactions-as-determined-by-x-ray-diffraction
#10
Samuel C R Sherratt, R Preston Mason
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) differentially influence lipid oxidation, signal transduction, fluidity, and cholesterol domain formation, potentially due in part to distinct membrane interactions. We used small angle X-ray diffraction to evaluate the EPA and DHA effects on membrane structure. Membrane vesicles composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and cholesterol (C) (0.3C:POPC mole ratio) were prepared and treated with vehicle, EPA, or DHA (1:10 mol ratio to POPC)...
January 31, 2018: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29343469/entrustable-professional-activities-a-useful-concept-for-neurology-education
#11
Holli Horak, Robert Englander, Diana Barratt, Jeff Kraakevik, Madhu Soni, Ezgi Tiryaki
Medical education is currently undergoing a paradigm shift from process-based to competency-based education, focused on measuring the desired competence of a physician. In an attempt to improve the assessment framework used for medical education, the concept of entrustable professional activities (EPAs) has gained traction. EPAs are defined as professional activities that can be entrusted to an individual in a clinical context. The Association of American Medical Colleges (AAMC) defined a set of 13 such EPAs to define the core of what all students should be able to do on day 1 of residency, regardless of specialty choice...
February 13, 2018: Neurology
https://www.readbyqxmd.com/read/29226233/medical-students-preparation-for-the-transition-to-postgraduate-training-through-final-year-elective-rotations
#12
W E Sjoukje van den Broek, Marjo Wijnen-Meijer, Olle Ten Cate, Marijke van Dijk
Objectives: This study adds to the ongoing discussion on how to ease the transition from undergraduate medical training to postgraduate training. In the Netherlands there is no central matching system for admission to residency. Medical school graduates just apply for a position in an open job market. Many choose to acquire general or specialty-specific clinical experiences after the medical degree before residency, to further explore career opportunities and to increase their chances to get into their preferred specialty...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/29138771/near-infrared-aza-bodipy-fluorescent-probe-for-selective-cu-2-detection-and-its-potential-in-living-cell-imaging
#13
Yordkhuan Tachapermpon, Sopida Thavornpradit, Adisri Charoenpanich, Jitnapa Sirirak, Kevin Burgess, Nantanit Wanichacheva
A near-infrared (NIR) fluorescent sensor 1 composed of an aza-boron-dipyrromethene (aza-BODIPY) core covalently bound to two di-2-picolylamine moieties was conceived for Cu2+ detection in aqueous solutions. Spectroscopic properties and binding abilities with several metal ions were investigated in phosphate buffered saline (pH 7.4): acetonitrile (95 : 5 v/v) with Triton X-100 via fluorometric titrations. The fluorescence of sensor 1 was quenched selectively by cupric ions in the presence of alkali- and transition-metal-ions...
November 28, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29098049/the-development-of-national-entrustable-professional-activities-to-inform-the-training-and-assessment-of-public-health-and-preventative-medicine-residents
#14
Brent Moloughney, Kieran Moore, Damon Dagnone, David Strong
Background: Entrustable Professional Activities (EPAs) have emerged to bridge the gap between the learning of individual competencies and competence in real world practice. EPAs capture the critical core work of a discipline integrating competencies from multiple domains. This report describes the development of a set of EPAs for specialty training in Public Health and Preventive Medicine (PHPM) in Canada. Methods: The PHPM EPAs were developed using multiple existing sources...
June 2017: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/29084324/entrustable-professional-activities-for-entering-residency-establishing-common-osteopathic-performance-standards-in-the-transition-from-medical-school-to-residency
#15
Pamela M Basehore, Luke H Mortensen, Emmanuel Katsaros, Machelle Linsenmeyer, Elizabeth K McClain, Patricia S Sexton, Nicole Wadsworth
Entrustable professional activities (EPAs) are measurable units of observable professional practice that can be entrusted to an unsupervised trainee. They were first introduced as a method of operationalizing competency-based medical education in graduate medical education. The American Association of Medical Colleges subsequently used EPAs to establish the core skills that medical students must be able to perform before they enter residency training. A recently published guide provides descriptions, guidelines, and rationale for implementing and assessing the core EPAs from an osteopathic approach...
November 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29075377/program-director-perceptions-of-proficiency-in-the-core-entrustable-professional-activities
#16
R Ellen Pearlman, Melissa Pawelczak, Andrew C Yacht, Salaahuddin Akbar, Gino A Farina
BACKGROUND : The Association of American Medical Colleges describes 13 core entrustable professional activities (EPAs) that every graduating medical student should be expected to perform proficiently on day 1 of residency, regardless of chosen specialty. Studies have shown wide variability in program director (PD) confidence in interns' abilities to perform these core EPAs. Little is known regarding comparison of United States Medical Licensing Examination (USMLE) scores with proficiency in EPAs...
October 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28991844/criterion-based-assessment-in-a-norm-based-world-how-can-we-move-past-grades
#17
Anne G Pereira, Majka Woods, Andrew P J Olson, Suzanne van den Hoogenhof, Briar L Duffy, Robert Englander
In the United States, the medical education community has begun a shift from the Flexnerian time-based model to a competency-based medical education model. The graduate medical education (GME) community is substantially farther along in this transition than is the undergraduate medical education (UME) community.GME has largely adopted the use of competencies and their attendant milestones and increasingly is employing the framework of entrustable professional activities (EPAs) to assess trainee competence. The UME community faces several challenges to successfully navigating a similar transition...
October 3, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28930762/competency-based-medical-education-in-the-internal-medicine-clerkship-a-report-from-the-alliance-for-academic-internal-medicine-undergraduate-medical-education-task-force
#18
Sara B Fazio, Cynthia H Ledford, Paul B Aronowitz, Shobhina G Chheda, John H Choe, Stephanie A Call, Scott D Gitlin, Marty Muntz, L James Nixon, Anne G Pereira, John W Ragsdale, Emily A Stewart, Karen E Hauer
As medical educators continue to redefine learning and assessment across the continuum, implementation of competency-based medical education in the undergraduate setting has become a focus of many medical schools. While standards of competency have been defined for the graduating student, there is no uniform approach for defining competency expectations for students during their core clerkship year. The authors describe the process by which an Alliance for Academic Internal Medicine task force developed a paradigm for competency-based assessment of students during their inpatient internal medicine (IM) clerkship...
March 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28930197/red-blood-cell-eicosapentaenoic-acid-inversely-relates-to-mri-assessed-carotid-plaque-lipid-core-burden-in-elders-at-high-cardiovascular-risk
#19
Núria Bargalló, Rosa Gilabert, Edwin-Saúl Romero-Mamani, Montserrat Cofán, Philip C Calder, Montserrat Fitó, Dolores Corella, Jordi Salas-Salvadó, Miguel Ruiz-Canela, Ramon Estruch, Emilio Ros, Aleix Sala-Vila
Supplemental marine omega-3 eicosapentaenoic acid (EPA) has an anti-atherosclerotic effect. Clinical research on EPA supplied by the regular diet and atherosclerosis is scarce. In the framework of the PREvención con DIeta MEDiterránea (PREDIMED) trial, we conducted a cross-sectional study in 161 older individuals at high vascular risk grouped into different stages of carotid atherosclerosis severity, including those without ultrasound-detected atheroma plaque (n = 38), with plaques <2.0 mm thick (n = 65), and with plaques ≥2...
September 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28857790/critical-thoughts-about-the-core-entrustable-professional-activities-in-undergraduate-medical-education
#20
Edward Krupat
The Core Entrustable Professional Activities for Entering Residency (Core EPAs) have taken a strong hold on undergraduate medical education (UME). This Perspective questions their value added and considers the utility of the Core EPAs along two separate dimensions: (1) the ways they change the content and focus of the goals of UME; and (2) the extent to which entrustable professional activity (EPA)-based assessment conforms to basic principles of measurement theory as practiced in the social sciences. Concerning content and focus, the author asks whether the 13 Core EPAs frame UME too narrowly, putting competencies into the background and overlooking certain aspirational, but important and measurable, objectives of UME...
March 2018: Academic Medicine: Journal of the Association of American Medical Colleges
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