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Mammary analogue secretory carcinoma

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https://www.readbyqxmd.com/read/27760615/-mammary-analogue-secretory-carcinoma-of-salivary-gland-report-of-a-case
#1
B Zhou, H Chen, J Wang
No abstract text is available yet for this article.
October 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27720350/cytogenetic-and-immunohistochemical-characterization-of-mammary-analogue-secretory-carcinoma-of-salivary-glands
#2
Syed A Khurram, Jemel Sultan-Khan, Neil Atkey, Paul M Speight
OBJECTIVES: Mammary analogue secretory carcinoma (MASC), initially considered a subset of acinic cell carcinoma (ACC), harbors an ETV6 translocation [t(12:15)(p13:25 q)] and is now regarded as a distinct entity. Several putative markers to differentiate MASC from ACC have been reported; however, the immunohistochemical profile is still being explored and updated. The purpose of this study was to further explore the cytogenetic and immunohistochemical profile of MASC. STUDY DESIGN: Cases were analyzed for ETV6 translocation using fluorescent in situ hybridization and stained for CK8, amylase, mammaglobin, GCDFP-15, MUC1, MUC4, STAT5a, Ki-67 (n = 37), CK7, Cam5...
July 20, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27670353/combined-dog1-and-mammaglobin-immunohistochemistry-is-comparable-to-etv6-breakapart-analysis-for-differentiating-between-papillary-cystic-variants-of-acinic-cell-carcinoma-and-mammary-analogue-secretory-carcinoma
#3
Nasser Said-Al-Naief, Roman Carlos, Gail H Vance, Caroline Miller, Paul C Edwards
Background We investigated the reliability of combined DOG1 and mammaglobin immunohistochemistry compared with ETV6 fluorescence in situ hybridization (FISH) in the assessment of salivary tumors previously diagnosed as acinic cell carcinoma (ACC). Ultrastructural features of cases reclassified as mammary analogue secretory carcinoma (MASC) were assessed by transmission electron microscopy (TEM). Methods Immunohistochemical (IHC) reactivity to DOG1 and mammaglobin was validated against FISH targeting the ETV6 gene in all 14 cases...
September 26, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27658560/extended-immunologic-and-genetic-lineage-of-mammary-analogue-secretory-carcinoma-of-salivary-glands
#4
Hao Ni, Xue-Ping Zhang, Xiao-Tong Wang, Qiu-Yuan Xia, Jing-Huan Lv, Xuan Wang, Shan-Shan Shi, Rui Li, Xiao-Jun Zhou, Qiu Rao
Mammary analogue secretory carcinoma (MASC) of salivary glands is a newly recognized tumor entity. To explore a more practical and convenient immunohistochemical approach to distinguish MASC from other tumors arising from salivary glands as well as to expand the immunologic and genetic lineage of MASC, we examined 17 MASC using clinicopathologic, immunohistochemical and molecular analysis. 18 cases of acinic cell carcinoma (AciCC), 18 cases of adenoid cystic carcinoma (ACC), 22 cases of mucoepidermoid carcinoma (MEC), and 14 cases of basal cell adenocarcinoma (BCA) were brought in for comparison...
September 19, 2016: Human Pathology
https://www.readbyqxmd.com/read/27631515/secretory-carcinoma-of-the-skin-harboring-etv6-gene-fusions-a-cutaneous-analogue-to-secretory-carcinomas-of-the-breast-and-salivary-glands
#5
Justin A Bishop, Janis M Taube, Albert Su, Scott W Binder, Dmitry V Kazakov, Michal Michal, William H Westra
Mammary analogue secretory carcinoma is a low-grade salivary gland carcinoma that exhibits analogous features to secretory carcinoma of the breast including the presence of a t(12;15) translocation resulting in the ETV6-NTRK3 gene fusion. Rare cases of purported secretory carcinoma of the skin adnexa have been reported, but their relationship to true secretory carcinoma of the breast and salivary glands is unclear, as they generally do not harbor ETV6 rearrangements. Cases of cutaneous neoplasms with histologic features identical to secretory carcinoma of the breast and salivary glands were identified from the consultation files of 3 academic medical institutions...
September 14, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27575269/mammary-analogue-secretory-carcinoma
#6
Todd M Stevens, Vishwas Parekh
Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor that shares the same histologic appearance and ETV6 gene (12p13) rearrangement as secretory carcinoma of the breast. Prior to its recognition, MASC cases were commonly labeled acinic cell carcinoma and adenocarcinoma, not otherwise specified. Despite distinctive histologic features, MASC may be difficult to distinguish from other salivary gland tumors, in particular zymogen-poor acinic cell carcinoma and low-grade salivary duct carcinoma...
September 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27527989/mammary-analogue-secretory-carcinoma-of-the-salivary-glands-a-diagnostic-dilemma
#7
N Hindocha, M H Wilson, M Pring, C W Hughes, S J Thomas
Mammary analogue secretory carcinoma (MASC) is a recently identified salivary gland neoplasm that can mimic other salivary gland tumours such as acinic cell carcinoma and cystadenocarcinoma. It is distinguished from these by differences in immunohistochemical profile and the identification of an ETV6-NTRK3 translocation (12;15)(p13;q25), which is also found in secretory carcinomas of the breast. Previous publications have suggested that MASC tumours have similar biological behaviour to acinic cell carcinoma...
August 12, 2016: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/27526014/-new-developments-in-molecular-diagnostics-of-carcinomas-of-the-salivary-glands-translocation-carcinomas
#8
Alena Skálová, Petr Šteiner, Tomáš Vaneček
In recent years the discovery of translocations and the fusion oncogenes that they result in has changed the way diagnoses are made in salivary gland pathology. These genetic aberrations are recurrent; and at the very least serve as powerful diagnostic tools in salivary gland tumors diagnosis and classification. They also show promise as prognostic markers and hopefully as targets of therapy. In this review the 4 carcinomas currently known to harbor translocations will be discussed, namely mucoepidermoid carcinoma, adenoid cystic carcinoma, mammary analogue secretory carcinoma, and hyalinizing clear cell carcinoma...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27506949/etv6-rearrangement-in-a-case-of-mammary-analogue-secretory-carcinoma-of-the-skin
#9
Michael D Chang, Allison K Arthur, Joaquín J García, William R Sukov, Wonwoo Shon
Mammary analog secretory carcinoma of salivary glands is a relatively recently recognized entity that harbors the ETV6-NTRK3 fusion transcript. To date, only rare cases of mammary analog secretory carcinoma of the skin have been reported. A 57-year-old man presented with a 6.0 cm cystic mass in the axilla, involving the dermis and superficial subcutis. Microscopically, the tumor exhibited nodular aggregation of tubular and microcystic structures embedded in the dense fibrotic and hyalinized stroma. Characteristic 'colloid-like' eosinophilic secretory material was present within intraluminal spaces...
November 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27483184/mammary-analogue-secretory-carcinoma-masc-of-the-salivary-gland-a-new-tumor-entity
#10
Ivan Damjanov, Faruk Skenderi, Semir Vranic
Mammary analogue secretory carcinoma (MASC) is a recently described low-grade malignant tumor of the salivary glands, biologically and morphologically equivalent to secretory breast carcinoma. We give a brief overview of this new entity, including morphological, immunohistochemical, molecular-genetic, clinical, epidemiologic features, differential diagnosis, and outcome results.
August 2, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27327192/sox10-positive-salivary-gland-tumors-a-growing-list-including-mammary-analogue-secretory-carcinoma-of-the-salivary-gland-sialoblastoma-low-grade-salivary-duct-carcinoma-basal-cell-adenoma-adenocarcinoma-and-a-subgroup-of-mucoepidermoid-carcinoma
#11
Min-Shu Hsieh, Yi-Hsuan Lee, Yih-Leong Chang
Transcription factor SRY-related HMG-box 10 (SOX10) is an important marker for melanocytic, schwannian, myoepithelial, and some salivary gland tumors. The aim of this study was to investigate SOX10 expression more thoroughly in the salivary gland neoplasms, including mammary analogue secretory carcinoma and hyalinizing clear cell carcinoma harboring specific genetic rearrangements. A new rabbit monoclonal anti-SOX10 antibody (clone EP268) was used to examine SOX10 expression in 14 different types of salivary gland tumors...
October 2016: Human Pathology
https://www.readbyqxmd.com/read/27192652/preservation-of-facial-nerve-with-adjuvant-radiotherapy-for-recurrent-mammary-analogue-secretory-carcinoma-of-parotid-gland
#12
Shufang Jin, Hailong Ma, Yue He
Mammary analogue secretory carcinoma of salivary glands harbors the recurrent ETV6-NTRK3 gene fusion because of the translocation t (12; 15) (p13; q25) and resembles breast secretory carcinoma. This tumor composed of papillary, cystic, solid, and cribriform patterns. Immunohistochemically, the tumors are positive for mammaglobin, CK7, CK8, STAT5a, vimentin, and S100. In this report, the authors presented a patient of recurrent parotid gland mammary analogue secretory carcinoma in a 22-year-old woman. The patient received extended parotidectomy with partial adhesive masseter surgery...
June 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27180060/mammary-analogue-secretory-carcinoma-of-salivary-glands-a-clinicopathologic-study-of-11-cases
#13
Nasir Ud Din, Saira Fatima, Naila Kayani
Mammary analogue secretory carcinoma (MASC) is a recently described tumor sharing the histologic, immunohistochemical, and molecular profile of secretory carcinoma of breast. We aimed to evaluate the morphologic and histochemical features needed/required for the diagnosis of MASC without adjunct of molecular analysis. Six retrospective cases suspicious for MASC and 5 prospective cases reported as MASC were included in the study. Molecular analysis of ETV6 by fluorescence in situ hybridization was performed at the University of Pittsburg, USA...
June 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27131022/mammary-analogue-secretory-carcinoma-masc-of-the-salivary-gland-a-new-tumor-entity
#14
Ivan Damjanov, Faruk Skenderi, Semir Vranic
Mammary analogue secretory carcinoma (MASC) is a recently described low-grade malignant tumor of the salivary glands, biologically and morphologically equivalent to secretory breast carcinoma. We give a brief overview of this new entity, including morphological, immunohistochemical, molecular-genetic, clinical, epidemiologic features, differential diagnosis, and outcome results.
August 2, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27017401/high-grade-transformation-of-acinic-cell-carcinoma-an-inadequately-treated-entity
#15
Ashish V Chintakuntlawar, Wonwoo Shon, Michele Erickson-Johnson, Elizabeth Bilodeau, Sarah M Jenkins, Jennifer A Davidson, Michael G Keeney, Michael Rivera, Daniel L Price, Eric J Moore, Kerry D Olsen, Jan L Kasperbauer, Robert L Foote, Katharine A Price, Joaquín J García
OBJECTIVE: Acinic cell carcinoma (AcCC) is an uncommon salivary gland malignancy. We aim to characterize the clinical and pathologic characteristics of AcCC with and without high-grade transformation (HGT). Importantly, cases of mammary analogue secretory carcinoma, a recently described histologic mimic of AcCC, have been excluded by using cytogenetics and molecular studies. STUDY DESIGN: Archival surgical pathology material was obtained for patients diagnosed with AcCC at Mayo Clinic Rochester between 1990 and 2010...
May 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/26945684/mammary-analogue-secretory-carcinoma-of-parotid-is-preoperative-cytological-diagnosis-possible
#16
Nikita Oza, Kintan Sanghvi, Tanuja Shet, Asawari Patil, Santosh Menon, Mukta Ramadwar, Shubhada Kane
Mammary analogue secretory carcinoma is a recently recognized tumor of salivary gland with characteristic t(12;15)(q13;q25) that results in ETV6-NTRK3 fusion product. Distinguishing mammary analogue secretory carcinoma from other salivary gland tumors is important. Present study highlights cytologic findings in three cases of mammary analogue secretory carcinoma of parotid which facilitate preoperative diagnosis with the aid of ancillary diagnostic techniques. Fine needle aspiration cytology of parotid was performed on three cases after clinical examination...
June 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/26928905/genetic-alterations-in-salivary-gland-cancers
#17
REVIEW
Linda X Yin, Patrick K Ha
Salivary gland cancers are an incredibly heterogeneous group of tumors that include 24 histologically distinct tumor types. The use of new genetic methods has paved the way for promising advancements in our understanding of the molecular biology underlying each type of tumor. The objective of this review was to highlight common oncogenes, tumor suppressor genes, and cytogenetic and epigenetic changes associated with the most common tumor types: mucoepidermoid carcinoma, adenoid cystic carcinoma, salivary duct carcinoma, mammary analogue secretory carcinoma, hyalinizing clear cell carcinoma, carcinoma ex pleomorphic adenoma, and acinic cell carcinoma...
June 15, 2016: Cancer
https://www.readbyqxmd.com/read/26884591/what-hides-behind-the-masc-clinical-response-and-acquired-resistance-to-entrectinib-after-etv6-ntrk3-identification-in-a-mammary-analogue-secretory-carcinoma-masc
#18
A Drilon, G Li, S Dogan, M Gounder, R Shen, M Arcila, L Wang, D M Hyman, J Hechtman, G Wei, N R Cam, J Christiansen, D Luo, E C Maneval, T Bauer, M Patel, S V Liu, S H I Ou, A Farago, A Shaw, R F Shoemaker, J Lim, Z Hornby, P Multani, M Ladanyi, M Berger, N Katabi, R Ghossein, A L Ho
BACKGROUND: Mammary analogue secretory carcinoma (MASC) is a recently described pathologic entity. We report the case of a patient with an initial diagnosis of salivary acinic cell carcinoma later reclassified as MASC after next-generation sequencing revealed an ETV6-NTRK3 fusion. PATIENTS AND METHODS: This alteration was targeted with the pan-Trk inhibitor entrectinib (Ignyta), which possesses potent in vitro activity against cell lines containing various NTRK1/2/3 fusions...
May 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/26808131/a-new-hitherto-unreported-histopathologic-manifestation-of-mammary-analogue-secretory-carcinoma-masked-masc-associated-with-low-grade-mucinous-adenocarcinoma-and-low-grade-in-situ-carcinoma-components
#19
Fredrik Petersson, Michael Michal, Dmitry V Kazakov, Petr Grossmann, Michal Michal
We present a salivary gland tumor of the parotid gland in a 54-year-old woman, which contained a minor mammary analogue secretory carcinoma (MASC) component (20%) intermixed with a morphologically entirely different mucinous adenocarcinomatous component that comprised 80% of the tumor mass and a morphologically nondescript low-grade intraductal carcinoma (in situ) component. On fluorescence in situ hybridization, a break in the ETV6 gene was documented in the mucinous adenocarcinomatous, the conventional MASC, and the intraductal (in situ) components...
January 22, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/26783481/mammary-analogue-secretory-carcinoma-of-the-parotid-gland-a-third-world-country-perspective-a-case-series
#20
Huzaifah Salat, Ramiz Mumtaz, Mubasher Ikram, Nasir Ud Din
Mammary analogue secretory carcinoma (MASC) is a recently described pathological entity in major salivary glands, which was first described by Skálová et al. in 2010. Since then only a limited number of case reports/series have been published describing this tumor with the majority of them discussing the genetic and cytoarchitectural aspect of this tumor. Keeping this in view with the lack of clinical correlation with regard to this tumor, we present our approach to management of two such cases which, according to the best of our knowledge, are the first 2 cases presenting in the South Asian continent...
2015: Case Reports in Otolaryngology
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