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https://www.readbyqxmd.com/read/28193618/incorporating-cancer-risk-information-into-general-practice-a-qualitative-study-using-focus-groups-with-health-professionals
#1
Juliet A Usher-Smith, Barbora Silarova, Alison Ward, Jane Youell, Kenneth R Muir, Jackie Campbell, Joanne Warcaba
BACKGROUND: It is estimated that approximately 40% of all cases of cancer are attributable to lifestyle factors. Providing people with personalised information about their future risk of cancer may help promote behaviour change. AIM: To explore the views of health professionals on incorporating personalised cancer risk information, based on lifestyle factors, into general practice. DESIGN AND SETTING: Qualitative study using data from six focus groups with a total of 24 general practice health professionals from the NHS Nene Clinical Commissioning Group in England...
February 13, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28169053/management-of-cancer-associated-venous-thromboembolism-in-the-emergency-department
#2
REVIEW
Rahul V Nene, Christopher J Coyne
Patients with cancer are at increased risk of venous thromboembolism, and emergency physicians can play a significant role in addressing one of the leading causes of morbidity and mortality in this patient population. However, there are no comprehensive guidelines addressing the approach to cancer-associated venous thromboembolism in the emergency department. Here, we review the guidelines put forth by various national and international cancer societies and highlight how emergency physicians can help institute appropriate treatment and prevent the recurrence of venous thromboembolism in cancer patients...
February 3, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28141928/highly-acidic-ambient-particles-soluble-metals-and-oxidative-potential-a-link-between-sulfate-and-aerosol-toxicity
#3
Ting Fang, Hongyu Guo, Linghan Zeng, Vishal Verma, Athanasios Nenes, Rodney J Weber
Soluble transition metals in particulate matter (PM) can generate reactive oxygen species in vivo by redox cycling, leading to oxidative stress and adverse health effects. Most metals, such as those from roadway traffic, are emitted in an insoluble form, but must be soluble for redox cycling. Here we present the mechanism of metals dissolution by highly acidic sulfate aerosol and the effect on particle oxidative potential (OP) through analysis of size distributions. Size-segregated ambient PM were collected from a road-side and representative urban site in Atlanta, GA...
January 31, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28126323/mutations-of-the-lim-protein-ajuba-mediate-sensitivity-of-head-and-neck-squamous-cell-carcinoma-to-treatment-with-cell-cycle-inhibitors
#4
Ming Zhang, Ratnakar Singh, Shaohua Peng, Tuhina Mazumdar, Vaishnavi Sambandam, Li Shen, Pan Tong, Lerong Li, Nene Kalu, Curtis R Pickering, Mitchell Frederick, Jeffrey N Myers, Jing Wang, Faye M Johnson
The genomic alterations identified in head and neck squamous cell carcinoma (HNSCC) tumors have not resulted in any changes in clinical care, making the development of biomarker-driven targeted therapy for HNSCC a major translational gap in knowledge. To fill this gap, we used 59 molecularly characterized HNSCC cell lines and found that mutations of AJUBA, SMAD4 and RAS predicted sensitivity and resistance to treatment with inhibitors of polo-like kinase 1 (PLK1), checkpoint kinases 1 and 2, and WEE1. Inhibition or knockdown of PLK1 led to cell-cycle arrest at the G2/M transition and apoptosis in sensitive cell lines and decreased tumor growth in an orthotopic AJUBA-mutant HNSCC mouse model...
January 23, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28111201/human-ipsc-derived-cerebral-organoids-model-cellular-features-of-lissencephaly-and-reveal-prolonged-mitosis-of-outer-radial-glia
#5
Marina Bershteyn, Tomasz J Nowakowski, Alex A Pollen, Elizabeth Di Lullo, Aishwarya Nene, Anthony Wynshaw-Boris, Arnold R Kriegstein
Classical lissencephaly is a genetic neurological disorder associated with mental retardation and intractable epilepsy, and Miller-Dieker syndrome (MDS) is the most severe form of the disease. In this study, to investigate the effects of MDS on human progenitor subtypes that control neuronal output and influence brain topology, we analyzed cerebral organoids derived from control and MDS-induced pluripotent stem cells (iPSCs) using time-lapse imaging, immunostaining, and single-cell RNA sequencing. We saw a cell migration defect that was rescued when we corrected the MDS causative chromosomal deletion and severe apoptosis of the founder neuroepithelial stem cells, accompanied by increased horizontal cell divisions...
January 9, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28056995/aldehyde-dehydrogenase-2-activation-and-coevolution-of-its-%C3%AE%C2%B5pkc-mediated-phosphorylation-sites
#6
Aishwarya Nene, Che-Hong Chen, Marie-Hélène Disatnik, Leslie Cruz, Daria Mochly-Rosen
BACKGROUND: Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is a key enzyme for the metabolism of many toxic aldehydes such as acetaldehyde, derived from alcohol drinking, and 4HNE, an oxidative stress-derived lipid peroxidation aldehyde. Post-translational enhancement of ALDH2 activity can be achieved by serine/threonine phosphorylation by epsilon protein kinase C (εPKC). Elevated ALDH2 is beneficial in reducing injury following myocardial infarction, stroke and other oxidative stress and aldehyde toxicity-related diseases...
January 5, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28042706/do-cdk4-6-inhibitors-have-potential-as-targeted-therapeutics-for-squamous-cell-cancers
#7
Nene N Kalu, Faye M Johnson
Introduction Dysregulation of cell cycle progression has an established link to neoplasia and cancer progression. Components of the cyclin D-CDK4/6-INK4-Rb pathway are frequently altered in squamous cell carcinomas (SCCs) by diverse mechanisms, including viral oncogene-induced degradation, mutation, deletion, and amplification. Activation of the CDK4/6 pathway may predict response to CDK4/6 inhibitors and provide clinical biomarkers. Recently, the CDK4/6 inhibitor palbociclib showed clinical efficacy in combination with cetuximab in HNSCC patients...
January 1, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28008727/nutrient-composition-of-premixed-and-packaged-complementary-foods-for-sale-in-low-and-middle-income-countries-lack-of-standards-threatens-infant-growth
#8
William A Masters, Marc D Nene, Winnie Bell
Premixed flours for infant porridge are increasingly produced and sold in developing countries to complement continued breastfeeding. Such complementary food (CF) products have known efficacy against malnutrition in children from 6 to 24 months of age, but ingredient ratios and production processes may vary. This study provides the first systematic measurement of their actual nutrient composition. We purchased samples of 108 premixed CF products in 22 low- and middle-income countries, and commissioned blind laboratory measurement of each product's macronutrients and micronutrients...
December 22, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27974156/floating-marine-debris-in-waters-of-the-mexican-central-pacific
#9
Evelyn R Díaz-Torres, Christian D Ortega-Ortiz, Lidia Silva-Iñiguez, Alejandro Nene-Preciado, Ernesto Torres Orozco
The presence of marine debris has been reported recently in several oceans basins; there is very little information available for Mexican Pacific coasts, however. This research examined the composition, possible sources, distribution, and density of Floating Marine Debris (FMD) during nine research surveys conducted during 2010-2012 in the Mexican Central Pacific (MCP). Of 1820 floating objects recorded, 80% were plastic items. Sources of FMD were determined using key objects, which indicated that the most were related to the presence of the industrial harbor and of a growing fishing industry in the study area...
December 11, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27930294/understanding-the-nature-of-atmospheric-acid-processing-of-mineral-dusts-in-supplying-bioavailable-phosphorus-to-the-oceans
#10
Anthony Stockdale, Michael D Krom, Robert J G Mortimer, Liane G Benning, Kenneth S Carslaw, Ross J Herbert, Zongbo Shi, Stelios Myriokefalitakis, Maria Kanakidou, Athanasios Nenes
Acidification of airborne dust particles can dramatically increase the amount of bioavailable phosphorus (P) deposited on the surface ocean. Experiments were conducted to simulate atmospheric processes and determine the dissolution behavior of P compounds in dust and dust precursor soils. Acid dissolution occurs rapidly (seconds to minutes) and is controlled by the amount of H(+) ions present. For H(+) < 10(-4) mol/g of dust, 1-10% of the total P is dissolved, largely as a result of dissolution of surface-bound forms...
December 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27856105/weakening-iliopsoas-muscle-in-healthy-adults-may-induce-stiff-knee-pattern
#11
N Ekin Akalan, Shavkat Kuchimov, Adnan Apti, Yener Temelli, Anand Nene
OBJECTIVE: The goal of the present study was to investigate the relationship between iliopsoas muscle group weakness and related hip joint velocity reduction and stiff-knee gait (SKG) during walking in healthy individuals. METHODS: A load of 5% of each individual's body weight was placed on non-dominant thigh of 15 neurologically intact, able-bodied participants (average age: 22.4 ± 0.81 years). For 33 min (135 s × 13 repetitions × 5 s rest), a passive stretch (PS) was applied with the load in place until hip flexor muscle strength dropped from 5/5 to 3+/5 according to manual muscle test...
December 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27790320/surgical-management-in-elderly-patients-with-tuberculous-spondylodiscitis-ten-year-mortality-audit-study
#12
Manish Kundanmal Kothari, Kunal Chandrakant Shah, Agnivesh Tikoo, Abhay Madhusudan Nene
STUDY DESIGN: Retrospective study. PURPOSE: To evaluate the factors affecting immediate postoperative mortality in elderly patients with tuberculous spondylodiscitis. OVERVIEW OF LITERATURE: Treatment of spinal tuberculosis in the elderly involves consideration of age and co-morbidities, and often leads to an extended conservative management. Surgical intervention in these patients becomes a complex decision. There are no studies on risk factors of mortality in surgically treated elderly with tuberculous spondylodiscitis...
October 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27789796/global-atmospheric-particle-formation-from-cern-cloud-measurements
#13
Eimear M Dunne, Hamish Gordon, Andreas Kürten, João Almeida, Jonathan Duplissy, Christina Williamson, Ismael K Ortega, Kirsty J Pringle, Alexey Adamov, Urs Baltensperger, Peter Barmet, Francois Benduhn, Federico Bianchi, Martin Breitenlechner, Antony Clarke, Joachim Curtius, Josef Dommen, Neil M Donahue, Sebastian Ehrhart, Richard C Flagan, Alessandro Franchin, Roberto Guida, Jani Hakala, Armin Hansel, Martin Heinritzi, Tuija Jokinen, Juha Kangasluoma, Jasper Kirkby, Markku Kulmala, Agnieszka Kupc, Michael J Lawler, Katrianne Lehtipalo, Vladimir Makhmutov, Graham Mann, Serge Mathot, Joonas Merikanto, Pasi Miettinen, Athanasios Nenes, Antti Onnela, Alexandru Rap, Carly L S Reddington, Francesco Riccobono, Nigel A D Richards, Matti P Rissanen, Linda Rondo, Nina Sarnela, Siegfried Schobesberger, Kamalika Sengupta, Mario Simon, Mikko Sipilä, James N Smith, Yuri Stozkhov, Antonio Tomé, Jasmin Tröstl, Paul E Wagner, Daniela Wimmer, Paul M Winkler, Douglas R Worsnop, Kenneth S Carslaw
Fundamental questions remain about the origin of newly formed atmospheric aerosol particles because data from laboratory measurements have been insufficient to build global models. In contrast, gas-phase chemistry models have been based on laboratory kinetics measurements for decades. We built a global model of aerosol formation by using extensive laboratory measurements of rates of nucleation involving sulfuric acid, ammonia, ions, and organic compounds conducted in the CERN CLOUD (Cosmics Leaving Outdoor Droplets) chamber...
December 2, 2016: Science
https://www.readbyqxmd.com/read/27783429/ultrasound-lineal-measurements-predict-ventricular-volume-in-posthaemorrhagic-ventricular-dilatation-in-preterm-infants
#14
Isabel Benavente-Fernandez, Manuel Lubián-Gutierrez, Gema Jimenez-Gomez, Alfonso M Lechuga-Sancho, Simon P Lubián-López
AIM: Posthaemorrhagic ventricular dilatation (PHVD) is monitored by conventional two-dimensional ultrasound (2DUS). The aims of this study were to determine the volume of the lateral ventricles using three-dimensional ultrasound (3DUS) in preterm infants with PHVD and to evaluate the relationship between volume and linear measurements. METHODS: Serial 2DUSs and 3DUSs were performed on preterm infants with PHVD admitted to the neonatal intensive care unit at Puerta del Mar Hospital, Cádiz, Spain, from January 2013 to December 2014...
February 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/27762122/hemoptysis-due-to-tracheal-diverticulum
#15
Namrata Kewalramani, Amita Nene
Tracheal diverticulum is a rare entity with only 79 symptomatic cases reported till date. We herein describe the case of a 38 year old male who presented with recurrent dry cough and hemoptysis and was diagnosed to have tracheal diverticulum on High Resolution Computed Tomography (HRCT) of chest. This was further confirmed on fibre optic bronchoscopy.
August 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27647496/approaches-to-vaccination-against-theileria-parva-and-theileria-annulata
#16
REVIEW
V Nene, W I Morrison
Despite having different cell tropism, the pathogenesis and immunobiology of the diseases caused by Theileria parva and Theileria annulata are remarkably similar. Live vaccines have been available for both parasites for over 40 years, but although they provide strong protection, practical disadvantages have limited their widespread application. Efforts to develop alternative vaccines using defined parasite antigens have focused on the sporozoite and intracellular schizont stages of the parasites. Experimental vaccination studies using viral vectors expressing T...
December 2016: Parasite Immunology
https://www.readbyqxmd.com/read/27639019/from-hygroscopic-aerosols-to-cloud-droplets-the-hygra-cd-campaign-in-the-athens-basin-an-overview
#17
A Papayannis, A Argyrouli, A Bougiatioti, E Remoundaki, S Vratolis, A Nenes, S Solomos, M Komppula, E Giannakaki, J Kalogiros, R Banks, K Eleftheriadis, E Mantas, E Diapouli, C G Tzanis, S Kazadzis, I Binietoglou, L Labzovskii, J Vande Hey, C S Zerefos
The international experimental campaign Hygroscopic Aerosols to Cloud Droplets (HygrA-CD), organized in the Greater Athens Area (GAA), Greece from 15 May to 22 June 2014, aimed to study the physico-chemical properties of aerosols and their impact on the formation of clouds in the convective Planetary Boundary Layer (PBL). We found that under continental (W-NW-N) and Etesian (NE) synoptic wind flow and with a deep moist PBL (~2-2.5km height), mixed hygroscopic (anthropogenic, biomass burning and marine) particles arrive over the GAA, and contribute to the formation of convective non-precipitating PBL clouds (of ~16-20μm mean diameter) with vertical extent up to 500m...
September 14, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27572179/validation-of-an-automatic-diagnosis-of-strict-left-bundle-branch-block-criteria-using-12-lead-electrocardiograms
#18
Xiaojuan Xia, Anne-Christine Ruwald, Martin H Ruwald, Nene Ugoeke, Barbara Szepietowska, Valentina Kutyifa, Mehmet K Aktas, Poul Erik B Thomsen, Wojciech Zareba, Arthur J Moss, Jean-Philippe Couderc
AIMS: Strict left bundle branch block (LBBB) criteria were recently proposed to identify LBBB patients to benefit most from cardiac resynchronization therapy (CRT). The aim of our study was to automate identification of strict LBBB in order to facilitate its broader application. METHODS: We developed a series of algorithms to automatically detect and measure parameters required for strict LBBB criteria and proposed a definition of QRS notch detection. The algorithms were developed using training (n = 20) and validation (n = 592) sets consisting of signal-averaged 12-lead ECGs (1,000 Hz sampling) recorded from 612 LBBB patients from Multicenter Automatic Defibrillator Implantation Trial-CRT...
August 30, 2016: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/27512215/total-enbloc-spondylectomy-for-metastatic-high-grade-spinal-tumors-early-results
#19
Sanganagouda S Patil, Abhay M Nene
BACKGROUND: High grade metastatic spinal tumors are most common and are invasive. These patients can succumb to disease progression if not treated timely. Although considered as invasive and morbid, total enbloc spondylectomy (TES) in selected cases has better survival rates. The authors describe the results of TES for high grade metastatic spinal tumors. MATERIALS AND METHODS: Five patients (four females and one male) underwent TES for solitary metastatic vertebral lesion between November 2012 and January 2014...
July 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27484705/rapid-reconstitution-of-cd4-t-cells-and-nk-cells-protects-against-cmv-reactivation-after-allogeneic-stem-cell-transplantation
#20
Julia Drylewicz, Ingrid M M Schellens, Rogier Gaiser, Nening M Nanlohy, Esther D Quakkelaar, Henny Otten, Suzanne van Dorp, Ronald Jacobi, Leonie Ran, Sanne Spijkers, Dan Koning, Rob Schuurman, Ellen Meijer, Floortje L Pietersma, Jurgen Kuball, Debbie van Baarle
BACKGROUND: Epstein-Barr virus and Cytomegalovirus reactivations frequently occur after allogeneic stem cell transplantation (SCT). METHODS: Here we investigated the role of immune cell reconstitution in the onset and subsequent severity of EBV- and CMV-reactivation. To this end, 116 patients were prospectively sampled for absolute T cell (CD4 and CD8), B-cell (CD19) and NK-cell (CD16 and CD56) numbers weekly post-SCT during the first 3 months and thereafter monthly until 6 months post-SCT...
2016: Journal of Translational Medicine
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