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https://www.readbyqxmd.com/read/28873442/use-of-a-novel-antigen-expressing-system-to-study-the-salmonella-enterica-serovar-typhi-protein-recognition-by-t-cells
#1
Rosângela Salerno-Gonçalves, Hervé Tettelin, David Lou, Stephanie Steiner, Tasmia Rezwanul, Qin Guo, William D Picking, Vishvanath Nene, Marcelo B Sztein
Salmonella enterica serovar Typhi (S. Typhi), the causative agent of the typhoid fever, is a pathogen of great public health importance. Typhoid vaccines have the potential to be cost-effective measures towards combating this disease, yet the antigens triggering host protective immune responses are largely unknown. Given the key role of cellular-mediated immunity in S. Typhi protection, it is crucial to identify S. Typhi proteins involved in T-cell responses. Here, cells from individuals immunized with Ty21a typhoid vaccine were collected before and after immunization and used as effectors...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28790110/replication-stress-leading-to-apoptosis-within-the-s-phase-contributes-to-synergism-between-vorinostat-and-azd1775-in-hnscc-harboring-high-risk-tp53-mutation
#2
Noriaki Tanaka, Ameeta A Patel, Lin Tang, Natalie L Silver, Antje Lindemann, Hideaki Takahashi, Roman Jaksik, Xiayu Rao, Nene N Kalu, Tseng-Cheng Chen, Jiping Wang, Mitchell J Frederick, Faye M Johnson, Frederico Gleber-Netto, Siqing Fu, Marek Kimmel, Jing Wang, Walter N Hittelman, Curtis R Pickering, Jeffrey N Myers, Abdullah A Osman
PURPOSE: The cure rate for patients with advanced head and neck squamous cell carcinoma (HNSCC) remains poor due to resistance to standard therapy primarily consisting of chemoradiation. Since mutation of TP53 in HNSCC occurs in 60-80% of non-HPV associated cases and is in turn associated with resistance to these treatments, more effective therapies are needed. In this study, we evaluated the efficacy of a regimen combining vorinostat and AZD1775 in HNSCC cells with a variety of p53 mutations...
August 8, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28781391/microphysical-explanation-of-the-rh-dependent-water-affinity-of-biogenic-organic-aerosol-and-its-importance-for-climate
#3
N Rastak, A Pajunoja, J C Acosta Navarro, J Ma, M Song, D G Partridge, A Kirkevåg, Y Leong, W W Hu, N F Taylor, A Lambe, K Cerully, A Bougiatioti, P Liu, R Krejci, T Petäjä, C Percival, P Davidovits, D R Worsnop, A M L Ekman, A Nenes, S Martin, J L Jimenez, D R Collins, D O Topping, A K Bertram, A Zuend, A Virtanen, I Riipinen
A large fraction of atmospheric organic aerosol (OA) originates from natural emissions that are oxidized in the atmosphere to form secondary organic aerosol (SOA). Isoprene (IP) and monoterpenes (MT) are the most important precursors of SOA originating from forests. The climate impacts from OA are currently estimated through parameterizations of water uptake that drastically simplify the complexity of OA. We combine laboratory experiments, thermodynamic modeling, field observations, and climate modeling to (1) explain the molecular mechanisms behind RH-dependent SOA water-uptake with solubility and phase separation; (2) show that laboratory data on IP- and MT-SOA hygroscopicity are representative of ambient data with corresponding OA source profiles; and (3) demonstrate the sensitivity of the modeled aerosol climate effect to assumed OA water affinity...
May 28, 2017: Geophysical Research Letters
https://www.readbyqxmd.com/read/28761521/safety-and-efficacy-of-spinal-loop-rectangle-and-sublaminar-wires-for-osteoporotic-vertebral-compression-fracture-fixation
#4
Sanganagouda Shivanagouda Patil, Shekhar Yashwant Bhojaraj, Abhay Madhusudan Nene
BACKGROUND: Natural history of osteoporotic vertebral compression fractures (OVCFs), that is, collapse, loads the rigid pedicle screw rod construct in the absence of anterior column reconstruction, often leading to implant back outs. Semi rigid spinal loop rectangle and sublaminar wire construct allows controlled axial collapse and does not require anterior column reconstruction. MATERIALS AND METHODS: This is a retrospective study of 50 consecutive patients of OVCFs...
July 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28760483/preliminary-efficacy-investigations-of-oral-fipronil-against-anopheles-arabiensis-when-administered-to-zebu-cattle-bos-indicus-under-field-conditions
#5
Richard M Poché, Naftaly Githaka, Frans van Gool, Rebekah C Kading, Daniel Hartman, Larisa Polyakova, Edward Okoth Abworo, Vishvanath Nene, Saul Lozano-Fuentes
Globally, malaria remains one of the most important vector-borne diseases despite the extensive use of vector control, including indoor residual spraying (IRS) and insecticide-treated nets (ITNs). These control methods target endophagic vectors, whereas some malaria vectors, such as Anopheles arabiensis, preferentially feed outdoors on cattle, making it a complicated vector to control using conventional strategies. Our study evaluated whether treating cattle with a capsule containing the active ingredient (AI) fipronil could reduce vector density and sporozoite rates, and alter blood feeding behavior, when applied in a small-scale field study...
July 29, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28753852/desnt-a-poor-prognosis-category-of-human-prostate-cancer
#6
Bogdan-Alexandru Luca, Daniel S Brewer, Dylan R Edwards, Sandra Edwards, Hayley C Whitaker, Sue Merson, Nening Dennis, Rosalin A Cooper, Steven Hazell, Anne Y Warren, Rosalind Eeles, Andy G Lynch, Helen Ross-Adams, Alastair D Lamb, David E Neal, Krishna Sethia, Robert D Mills, Richard Y Ball, Helen Curley, Jeremy Clark, Vincent Moulton, Colin S Cooper
BACKGROUND: A critical problem in the clinical management of prostate cancer is that it is highly heterogeneous. Accurate prediction of individual cancer behaviour is therefore not achievable at the time of diagnosis leading to substantial overtreatment. It remains an enigma that, in contrast to breast cancer, unsupervised analyses of global expression profiles have not currently defined robust categories of prostate cancer with distinct clinical outcomes. OBJECTIVE: To devise a novel classification framework for human prostate cancer based on unsupervised mathematical approaches...
March 6, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28730066/-these-are-not-luxuries-it-is-essential-for-access-to-life-disability-related-out-of-pocket-costs-as-a-driver-of-economic-vulnerability-in-south-africa
#7
Jill Hanass-Hancock, Siphumelele Nene, Nicola Deghaye, Simmi Pillay
BACKGROUND: With the dawn of the new sustainable development goals, we face not only a world that has seen great successes in alleviating poverty but also a world that has left some groups, such as persons with disabilities, behind. Middle-income countries (MICs) are home to a growing number of persons with disabilities. As these countries strive to achieve the new goals, we have ample opportunity to include persons with disabilities in the emerging poverty alleviation strategies. However, a lack of data and research on the linkages between economic vulnerability and disability in MICs hampers our understanding of the factors increasing economic vulnerability in people with disabilities...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28671188/revising-the-hygroscopicity-of-inorganic-sea-salt-particles
#8
P Zieger, O Väisänen, J C Corbin, D G Partridge, S Bastelberger, M Mousavi-Fard, B Rosati, M Gysel, U K Krieger, C Leck, A Nenes, I Riipinen, A Virtanen, M E Salter
Sea spray is one of the largest natural aerosol sources and plays an important role in the Earth's radiative budget. These particles are inherently hygroscopic, that is, they take-up moisture from the air, which affects the extent to which they interact with solar radiation. We demonstrate that the hygroscopic growth of inorganic sea salt is 8-15% lower than pure sodium chloride, most likely due to the presence of hydrates. We observe an increase in hygroscopic growth with decreasing particle size (for particle diameters <150 nm) that is independent of the particle generation method...
July 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/28640603/changes-in-light-absorptivity-of-molecular-weight-separated-brown-carbon-due-to-photolytic-aging
#9
Jenny P S Wong, Athanasios Nenes, Rodney J Weber
Brown carbon (BrC) consists of those organic compounds in atmospheric aerosols that absorb solar radiation and may play an important role in planetary radiative forcing and climate. However, little is known about the production and loss mechanisms of BrC in the atmosphere. Here, we study how the light absorptivity of BrC from wood smoke and secondary BrC generated from the reaction of ammonium sulfate with methylglyoxal changes under photolytic aging by UVA radiation in the aqueous phase. Owing to its chemical complexity, BrC is separated by molecular weight using size exclusion chromatography, and the response of each molecular weight fraction to aging is studied...
July 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28611503/exploiting-phosphate-starved-cells-of-scenedesmus-sp-for-the-treatment-of-raw-sewage
#10
Swati Yewalkar-Kulkarni, Gayatri Gera, Sanjay Nene, Kiran Pandare, Bhaskar Kulkarni, Sanjay Kamble
Phosphate depletion is one of the favorable ways to enhance the sewage water treatment with the algae, however, detailed information is essential with respect to internal phosphate concentration and physiology of the algae. The growth rate of the phosphate-starved Scenedesmus cells was reduced drastically after 48 h. Indicating cells entered in the stationary phase of the growth cycle. Fourier Transform Infrared analysis of phosphate-starved Scenedesmus cells showed the reduction in internal phosphate concentration and an increase in carbohydrate/phosphate and carbohydrate/lipid ratio...
June 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/28603566/current-concepts-in-pediatric-cervical-spine-trauma
#11
Kunal Shah, Agnivesh Tikoo, Manish K Kothari, Abhay Nene
BACKGROUND: Pediatric spinal trauma is rare and challenging entity. Although cervical spine is commonly affected, it is often missed on routine imaging investigations. Therefore better understanding of growing spine and its patho-physiology is crucial. METHODS: Articles related to pediatric cervical trauma were searched on Pubmed and other online research data banks. We have summarized unique anatomy of pediatric spine, investigations followed by common injury patterns, their diagnostic challenges and management...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28603565/current-concepts-congenital-scoliosis
#12
Agnivesh Tikoo, Manish K Kothari, Kunal Shah, Abhay Nene
BACKGROUND: Congenital scoliosis is one of the 'difficult to treat' scenarios which a spine surgeon has to face. Multiple factors including the age of child at presentation, no definite pattern of deformity and associated anomalies hinder the execution of the ideal treatment plan. All patients of congenital scoliosis need to be investigated in detail. X rays and MRI of spine is usually ordered first. Screening investigations to rule out VACTERL (Visceral, Anorectal, Cardiac, Tracheo-esophageal fistula, Renal and Lung) abnormalities are required...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28458968/the-aesthetic-items-scale-a-tool-for-the-evaluation-of-aesthetic-outcome-after-breast-reconstruction
#13
Rieky E G Dikmans, Lauren E H Nene, Mark-Bram Bouman, Henrica C W de Vet, Marc A M Mureau, Marlon E Buncamper, Hay A H Winters, Marco J P F Ritt, Margriet G Mullender
BACKGROUND: Valid tools to assess aesthetic outcomes after breast reconstructive surgery are scarce. Previously a professional aesthetic assessment scale was introduced, the Aesthetic Items Scale (AIS). We aim to determine if this method is a valid and reliable tool to assess aesthetic outcome after breast reconstructive surgery. METHODS: The study population was consenting women who underwent prophylactic mastectomy with subsequent implant-based breast reconstruction...
March 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28394569/simulating-aqueous-phase-isoprene-epoxydiol-iepox-secondary-organic-aerosol-production-during-the-2013-southern-oxidant-and-aerosol-study-soas
#14
Sri Hapsari Budisulistiorini, Athanasios Nenes, Annmarie G Carlton, Jason D Surratt, V Faye McNeill, Havala O T Pye
The lack of statistically robust relationships between IEPOX (isoprene epoxydiol)-derived SOA (IEPOX SOA) and aerosol liquid water and pH observed during the 2013 Southern Oxidant and Aerosol Study (SOAS) emphasizes the importance of modeling the whole system to understand the controlling factors governing IEPOX SOA formation. We present a mechanistic modeling investigation predicting IEPOX SOA based on Community Multiscale Air Quality (CMAQ) model algorithms and a recently introduced photochemical box model, simpleGAMMA...
May 2, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28350334/conceptions-of-contraceptive-use-in-rural-kwazulu-natal-south-africa-lessons-for-programming
#15
Catherine Ndinda, Tidings Ndhlovu, Nene Ernest Khalema
Community family planning programmes in South Africa arose from the controversial apartheid history of controlling the African population while encouraging the growth of European migrant population. Post-apartheid population policies shifted away from population control to aligning policies to the global agenda that placed emphasis on the link between population and development. The focus on population and development polices in post-apartheid South Africa is on social equality, justice and peace rather than controlling sections of the population...
March 28, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28303714/ph-of-aerosols-in-a-polluted-atmosphere-source-contributions-to-highly-acidic-aerosol
#16
Guoliang Shi, Jiao Xu, Xing Peng, Zhimei Xiao, Kui Chen, Yingze Tian, Xinbei Guan, Yinchang Feng, Haofei Yu, Athanasios Nenes, Armistead G Russell
Acidity (pH) plays a key role in the physical and chemical behavior of PM2.5. However, understanding of how specific PM sources impact aerosol pH is rarely considered. Performing source apportionment of PM2.5 allows a unique link of sources pH of aerosol from the polluted city. Hourly water-soluble (WS) ions of PM2.5 were measured online from December 25th, 2014 to June 19th, 2015 in a northern city in China. Five sources were resolved including secondary nitrate (41%), secondary sulfate (26%), coal combustion (14%), mineral dust (11%), and vehicle exhaust (9%)...
April 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28291234/collocated-observations-of-cloud-condensation-nuclei-particle-size-distributions-and-chemical-composition
#17
Julia Schmale, Silvia Henning, Bas Henzing, Helmi Keskinen, Karine Sellegri, Jurgita Ovadnevaite, Aikaterini Bougiatioti, Nikos Kalivitis, Iasonas Stavroulas, Anne Jefferson, Minsu Park, Patrick Schlag, Adam Kristensson, Yoko Iwamoto, Kirsty Pringle, Carly Reddington, Pasi Aalto, Mikko Äijälä, Urs Baltensperger, Jakub Bialek, Wolfram Birmili, Nicolas Bukowiecki, Mikael Ehn, Ann Mari Fjæraa, Markus Fiebig, Göran Frank, Roman Fröhlich, Arnoud Frumau, Masaki Furuya, Emanuel Hammer, Liine Heikkinen, Erik Herrmann, Rupert Holzinger, Hiroyuki Hyono, Maria Kanakidou, Astrid Kiendler-Scharr, Kento Kinouchi, Gerard Kos, Markku Kulmala, Nikolaos Mihalopoulos, Ghislain Motos, Athanasios Nenes, Colin O'Dowd, Mikhail Paramonov, Tuukka Petäjä, David Picard, Laurent Poulain, André Stephan Henry Prévôt, Jay Slowik, Andre Sonntag, Erik Swietlicki, Birgitta Svenningsson, Hiroshi Tsurumaru, Alfred Wiedensohler, Cerina Wittbom, John A Ogren, Atsushi Matsuki, Seong Soo Yum, Cathrine Lund Myhre, Ken Carslaw, Frank Stratmann, Martin Gysel
Cloud condensation nuclei (CCN) number concentrations alongside with submicrometer particle number size distributions and particle chemical composition have been measured at atmospheric observatories of the Aerosols, Clouds, and Trace gases Research InfraStructure (ACTRIS) as well as other international sites over multiple years. Here, harmonized data records from 11 observatories are summarized, spanning 98,677 instrument hours for CCN data, 157,880 for particle number size distributions, and 70,817 for chemical composition data...
March 14, 2017: Scientific Data
https://www.readbyqxmd.com/read/28285555/factors-affecting-the-rates-of-caesarean-sections-in-cases-with-premature-rupture-of-membranes-prom-at-term
#18
Muberra Namli Kalem, Aydın Köşüş, Zeynep Kamalak, Nermin Köşüş, Ziya Kalem
The aim of this retrospective study was to investigate the factors affecting the rates of caesarean section in cases with premature rupture of membranes (PROM) in term pregnancies. Eighty-two term PROM patients who presented to Turgut Ozal University and Erzurum Nene Hatun Hospitals between 2012 and 2014 were included. The effects of demographics, nulliparity, active-latent phase durations, presence of meconium and chorioamnionitis, requirement of oxytocin and cervical dilation at the initial examination on C/S rates were assessed...
March 13, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28275731/air-pollution-aerosol-interactions-produce-more-bioavailable-iron-for-ocean-ecosystems
#19
Weijun Li, Liang Xu, Xiaohuan Liu, Jianchao Zhang, Yangting Lin, Xiaohong Yao, Huiwang Gao, Daizhou Zhang, Jianmin Chen, Wenxing Wang, Roy M Harrison, Xiaoye Zhang, Longyi Shao, Pingqing Fu, Athanasios Nenes, Zongbo Shi
It has long been hypothesized that acids formed from anthropogenic pollutants and natural emissions dissolve iron (Fe) in airborne particles, enhancing the supply of bioavailable Fe to the oceans. However, field observations have yet to provide indisputable evidence to confirm this hypothesis. Single-particle chemical analysis for hundreds of individual atmospheric particles collected over the East China Sea shows that Fe-rich particles from coal combustion and steel industries were coated with thick layers of sulfate after 1 to 2 days of atmospheric residence...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28193618/incorporating-cancer-risk-information-into-general-practice-a-qualitative-study-using-focus-groups-with-health-professionals
#20
Juliet A Usher-Smith, Barbora Silarova, Alison Ward, Jane Youell, Kenneth R Muir, Jackie Campbell, Joanne Warcaba
BACKGROUND: It is estimated that approximately 40% of all cases of cancer are attributable to lifestyle factors. Providing people with personalised information about their future risk of cancer may help promote behaviour change. AIM: To explore the views of health professionals on incorporating personalised cancer risk information, based on lifestyle factors, into general practice. DESIGN AND SETTING: Qualitative study using data from six focus groups with a total of 24 general practice health professionals from the NHS Nene Clinical Commissioning Group in England...
March 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
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