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https://www.readbyqxmd.com/read/28056995/aldehyde-dehydrogenase-2-activation-and-coevolution-of-its-%C3%AE%C2%B5pkc-mediated-phosphorylation-sites
#1
Aishwarya Nene, Che-Hong Chen, Marie-Hélène Disatnik, Leslie Cruz, Daria Mochly-Rosen
BACKGROUND: Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is a key enzyme for the metabolism of many toxic aldehydes such as acetaldehyde, derived from alcohol drinking, and 4HNE, an oxidative stress-derived lipid peroxidation aldehyde. Post-translational enhancement of ALDH2 activity can be achieved by serine/threonine phosphorylation by epsilon protein kinase C (εPKC). Elevated ALDH2 is beneficial in reducing injury following myocardial infarction, stroke and other oxidative stress and aldehyde toxicity-related diseases...
January 5, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28042706/do-cdk4-6-inhibitors-have-potential-as-targeted-therapeutics-for-squamous-cell-cancers
#2
Nene N Kalu, Faye M Johnson
Introduction Dysregulation of cell cycle progression has an established link to neoplasia and cancer progression. Components of the cyclin D-CDK4/6-INK4-Rb pathway are frequently altered in squamous cell carcinomas (SCCs) by diverse mechanisms, including viral oncogene-induced degradation, mutation, deletion, and amplification. Activation of the CDK4/6 pathway may predict response to CDK4/6 inhibitors and provide clinical biomarkers. Recently, the CDK4/6 inhibitor palbociclib showed clinical efficacy in combination with cetuximab in HNSCC patients...
January 1, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28008727/nutrient-composition-of-premixed-and-packaged-complementary-foods-for-sale-in-low-and-middle-income-countries-lack-of-standards-threatens-infant-growth
#3
William A Masters, Marc D Nene, Winnie Bell
Premixed flours for infant porridge are increasingly produced and sold in developing countries to complement continued breastfeeding. Such complementary food (CF) products have known efficacy against malnutrition in children from 6 to 24 months of age, but ingredient ratios and production processes may vary. This study provides the first systematic measurement of their actual nutrient composition. We purchased samples of 108 premixed CF products in 22 low- and middle-income countries, and commissioned blind laboratory measurement of each product's macronutrients and micronutrients...
December 22, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27974156/floating-marine-debris-in-waters-of-the-mexican-central-pacific
#4
Evelyn R Díaz-Torres, Christian D Ortega-Ortiz, Lidia Silva-Iñiguez, Alejandro Nene-Preciado, Ernesto Torres Orozco
The presence of marine debris has been reported recently in several oceans basins; there is very little information available for Mexican Pacific coasts, however. This research examined the composition, possible sources, distribution, and density of Floating Marine Debris (FMD) during nine research surveys conducted during 2010-2012 in the Mexican Central Pacific (MCP). Of 1820 floating objects recorded, 80% were plastic items. Sources of FMD were determined using key objects, which indicated that the most were related to the presence of the industrial harbor and of a growing fishing industry in the study area...
December 11, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27930294/understanding-the-nature-of-atmospheric-acid-processing-of-mineral-dusts-in-supplying-bioavailable-phosphorus-to-the-oceans
#5
Anthony Stockdale, Michael D Krom, Robert J G Mortimer, Liane G Benning, Kenneth S Carslaw, Ross J Herbert, Zongbo Shi, Stelios Myriokefalitakis, Maria Kanakidou, Athanasios Nenes
Acidification of airborne dust particles can dramatically increase the amount of bioavailable phosphorus (P) deposited on the surface ocean. Experiments were conducted to simulate atmospheric processes and determine the dissolution behavior of P compounds in dust and dust precursor soils. Acid dissolution occurs rapidly (seconds to minutes) and is controlled by the amount of H(+) ions present. For H(+) < 10(-4) mol/g of dust, 1-10% of the total P is dissolved, largely as a result of dissolution of surface-bound forms...
December 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27856105/weakening-iliopsoas-muscle-in-healthy-adults-may-induce-stiff-knee-pattern
#6
N Ekin Akalan, Shavkat Kuchimov, Adnan Apti, Yener Temelli, Anand Nene
OBJECTIVE: The goal of the present study was to investigate the relationship between iliopsoas muscle group weakness and related hip joint velocity reduction and stiff-knee gait (SKG) during walking in healthy individuals. METHODS: A load of 5% of each individual's body weight was placed on non-dominant thigh of 15 neurologically intact, able-bodied participants (average age: 22.4 ± 0.81 years). For 33 min (135 s × 13 repetitions × 5 s rest), a passive stretch (PS) was applied with the load in place until hip flexor muscle strength dropped from 5/5 to 3+/5 according to manual muscle test...
November 14, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27790320/surgical-management-in-elderly-patients-with-tuberculous-spondylodiscitis-ten-year-mortality-audit-study
#7
Manish Kundanmal Kothari, Kunal Chandrakant Shah, Agnivesh Tikoo, Abhay Madhusudan Nene
STUDY DESIGN: Retrospective study. PURPOSE: To evaluate the factors affecting immediate postoperative mortality in elderly patients with tuberculous spondylodiscitis. OVERVIEW OF LITERATURE: Treatment of spinal tuberculosis in the elderly involves consideration of age and co-morbidities, and often leads to an extended conservative management. Surgical intervention in these patients becomes a complex decision. There are no studies on risk factors of mortality in surgically treated elderly with tuberculous spondylodiscitis...
October 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27789796/global-atmospheric-particle-formation-from-cern-cloud-measurements
#8
Eimear M Dunne, Hamish Gordon, Andreas Kürten, João Almeida, Jonathan Duplissy, Christina Williamson, Ismael K Ortega, Kirsty J Pringle, Alexey Adamov, Urs Baltensperger, Peter Barmet, Francois Benduhn, Federico Bianchi, Martin Breitenlechner, Antony Clarke, Joachim Curtius, Josef Dommen, Neil M Donahue, Sebastian Ehrhart, Richard C Flagan, Alessandro Franchin, Roberto Guida, Jani Hakala, Armin Hansel, Martin Heinritzi, Tuija Jokinen, Juha Kangasluoma, Jasper Kirkby, Markku Kulmala, Agnieszka Kupc, Michael J Lawler, Katrianne Lehtipalo, Vladimir Makhmutov, Graham Mann, Serge Mathot, Joonas Merikanto, Pasi Miettinen, Athanasios Nenes, Antti Onnela, Alexandru Rap, Carly L S Reddington, Francesco Riccobono, Nigel A D Richards, Matti P Rissanen, Linda Rondo, Nina Sarnela, Siegfried Schobesberger, Kamalika Sengupta, Mario Simon, Mikko Sipilä, James N Smith, Yuri Stozkhov, Antonio Tomé, Jasmin Tröstl, Paul E Wagner, Daniela Wimmer, Paul M Winkler, Douglas R Worsnop, Kenneth S Carslaw
Fundamental questions remain about the origin of newly formed atmospheric aerosol particles because data from laboratory measurements have been insufficient to build global models. In contrast, gas-phase chemistry models have been based on laboratory kinetics measurements for decades. We built a global model of aerosol formation by using extensive laboratory measurements of rates of nucleation involving sulfuric acid, ammonia, ions, and organic compounds conducted in the CERN CLOUD (Cosmics Leaving Outdoor Droplets) chamber...
December 2, 2016: Science
https://www.readbyqxmd.com/read/27783429/ultrasound-lineal-measurements-predict-ventricular-volume-in-posthaemorrhagic-ventricular-dilatation-in-preterm-infants
#9
Isabel Benavente-Fernandez, Manuel Lubián-Gutierrez, Gema Jimenez-Gomez, Alfonso M Lechuga-Sancho, Simon P Lubián-López
AIM: Posthaemorrhagic ventricular dilatation (PHVD) is monitored by conventional two-dimensional ultrasound (2DUS). The aims of this study were to determine the volume of the lateral ventricles using three-dimensional ultrasound (3DUS) in preterm infants with PHVD and to evaluate the relationship between volume and linear measurements. METHODS: Serial 2DUSs and 3DUSs were performed on preterm infants with PHVD admitted to the neonatal intensive care unit at Puerta del Mar Hospital, Cádiz, Spain, from January 2013 to December 2014...
February 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/27762122/hemoptysis-due-to-tracheal-diverticulum
#10
Namrata Kewalramani, Amita Nene
Tracheal diverticulum is a rare entity with only 79 symptomatic cases reported till date. We herein describe the case of a 38 year old male who presented with recurrent dry cough and hemoptysis and was diagnosed to have tracheal diverticulum on High Resolution Computed Tomography (HRCT) of chest. This was further confirmed on fibre optic bronchoscopy.
August 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27647496/approaches-to-vaccination-against-theileria-parva-and-theileria-annulata
#11
REVIEW
V Nene, W I Morrison
Despite having different cell tropism, the pathogenesis and immunobiology of the diseases caused by Theileria parva and Theileria annulata are remarkably similar. Live vaccines have been available for both parasites for over 40 years, but although they provide strong protection, practical disadvantages have limited their widespread application. Efforts to develop alternative vaccines using defined parasite antigens have focused on the sporozoite and intracellular schizont stages of the parasites. Experimental vaccination studies using viral vectors expressing T...
December 2016: Parasite Immunology
https://www.readbyqxmd.com/read/27639019/from-hygroscopic-aerosols-to-cloud-droplets-the-hygra-cd-campaign-in-the-athens-basin-an-overview
#12
A Papayannis, A Argyrouli, A Bougiatioti, E Remoundaki, S Vratolis, A Nenes, S Solomos, M Komppula, E Giannakaki, J Kalogiros, R Banks, K Eleftheriadis, E Mantas, E Diapouli, C G Tzanis, S Kazadzis, I Binietoglou, L Labzovskii, J Vande Hey, C S Zerefos
The international experimental campaign Hygroscopic Aerosols to Cloud Droplets (HygrA-CD), organized in the Greater Athens Area (GAA), Greece from 15 May to 22 June 2014, aimed to study the physico-chemical properties of aerosols and their impact on the formation of clouds in the convective Planetary Boundary Layer (PBL). We found that under continental (W-NW-N) and Etesian (NE) synoptic wind flow and with a deep moist PBL (~2-2.5km height), mixed hygroscopic (anthropogenic, biomass burning and marine) particles arrive over the GAA, and contribute to the formation of convective non-precipitating PBL clouds (of ~16-20μm mean diameter) with vertical extent up to 500m...
September 14, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27572179/validation-of-an-automatic-diagnosis-of-strict-left-bundle-branch-block-criteria-using-12-lead-electrocardiograms
#13
Xiaojuan Xia, Anne-Christine Ruwald, Martin H Ruwald, Nene Ugoeke, Barbara Szepietowska, Valentina Kutyifa, Mehmet K Aktas, Poul Erik B Thomsen, Wojciech Zareba, Arthur J Moss, Jean-Philippe Couderc
AIMS: Strict left bundle branch block (LBBB) criteria were recently proposed to identify LBBB patients to benefit most from cardiac resynchronization therapy (CRT). The aim of our study was to automate identification of strict LBBB in order to facilitate its broader application. METHODS: We developed a series of algorithms to automatically detect and measure parameters required for strict LBBB criteria and proposed a definition of QRS notch detection. The algorithms were developed using training (n = 20) and validation (n = 592) sets consisting of signal-averaged 12-lead ECGs (1,000 Hz sampling) recorded from 612 LBBB patients from Multicenter Automatic Defibrillator Implantation Trial-CRT...
August 30, 2016: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/27512215/total-enbloc-spondylectomy-for-metastatic-high-grade-spinal-tumors-early-results
#14
Sanganagouda S Patil, Abhay M Nene
BACKGROUND: High grade metastatic spinal tumors are most common and are invasive. These patients can succumb to disease progression if not treated timely. Although considered as invasive and morbid, total enbloc spondylectomy (TES) in selected cases has better survival rates. The authors describe the results of TES for high grade metastatic spinal tumors. MATERIALS AND METHODS: Five patients (four females and one male) underwent TES for solitary metastatic vertebral lesion between November 2012 and January 2014...
July 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27484705/rapid-reconstitution-of-cd4-t-cells-and-nk-cells-protects-against-cmv-reactivation-after-allogeneic-stem-cell-transplantation
#15
Julia Drylewicz, Ingrid M M Schellens, Rogier Gaiser, Nening M Nanlohy, Esther D Quakkelaar, Henny Otten, Suzanne van Dorp, Ronald Jacobi, Leonie Ran, Sanne Spijkers, Dan Koning, Rob Schuurman, Ellen Meijer, Floortje L Pietersma, Jurgen Kuball, Debbie van Baarle
BACKGROUND: Epstein-Barr virus and Cytomegalovirus reactivations frequently occur after allogeneic stem cell transplantation (SCT). METHODS: Here we investigated the role of immune cell reconstitution in the onset and subsequent severity of EBV- and CMV-reactivation. To this end, 116 patients were prospectively sampled for absolute T cell (CD4 and CD8), B-cell (CD19) and NK-cell (CD16 and CD56) numbers weekly post-SCT during the first 3 months and thereafter monthly until 6 months post-SCT...
2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27406822/challenges-of-being-new-to-canada-considerations-for-physical-activity
#16
Kimberley D Curtin, Christina C Loitz, Nancy Spencer-Cavaliere, Ernest Nene Khalema
Immigrants to Canada are less likely to be physically active compared with non-immigrants, and the interrelations between personal and environmental factors that influence physical activity for immigrants are largely unexplored. The goal of this qualitative descriptive study was to understand how the experience of being new to Canada impacts opportunities and participation in physical activity. Two focus group interviews with immigrants to Canada were conducted. The first group (n=7) included multicultural health brokers...
July 12, 2016: Global Health Promotion
https://www.readbyqxmd.com/read/27317557/evaluation-of-a-topical-formulation-of-eprinomectin-against-anopheles-arabiensis-when-administered-to-zebu-cattle-bos-indicus-under-field-conditions
#17
Saul Lozano-Fuentes, Rebekah C Kading, Daniel A Hartman, Edward Okoth, Naftaly Githaka, Vishvanath Nene, Richard M Poché
BACKGROUND: Although vector control strategies, such as insecticide-treated bed nets (ITNs) and indoor residual spraying (IRS) have been effective in Kenya the transmission of malaria continues to afflict western Kenya. This residual transmission is driven in part by Anopheles arabiensis, known for its opportunistic blood feeding behaviour and propensity to feed outdoors. The objective of this research was to evaluate the efficacy of the drug eprinomectin at reducing malaria vector density when applied to cattle (Bos indicus), the primary source of blood for An...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27307782/substance-use-and-duration-of-untreated-psychosis-in-kwazulu-natal-south-africa
#18
Glen P Davis, Andrew Tomita, Joy Noel Baumgartner, Sisanda Mtshemla, Siphumelele Nene, Howard King, Ezra Susser, Jonathan K Burns
BACKGROUND: Substance use and psychiatric disorders cause significant burden of disease in low- and middle-income countries. Co-morbid psychopathology and longer duration of untreated psychosis (DUP) can negatively affect treatment outcomes. OBJECTIVES: The study assessed substance use amongst adults with severe mental illness receiving services at a regional psychiatric hospital in KwaZulu-Natal (South Africa). We describe the prevalence and correlates of lifetime substance use and examine the association between substance use and DUP...
2016: South African Journal of Psychiatry: SAJP: the Journal of the Society of Psychiatrists of South Africa
https://www.readbyqxmd.com/read/27301315/real-time-online-automated-system-for-measurement-of-water-soluble-reactive-phosphate-ions-in-atmospheric-particles
#19
Kalliopi Violaki, Ting Fang, Nikos Mihalopoulos, Rodney Weber, Athanasios Nenes
We present a novel automated system for real-time measurements of water-soluble reactive phosphate (SRP) ions in atmospheric particles. Detection of SRP is based on molybdenum blue chemistry with Sn(II) chloride dihydrate reduction. The instrumentation consists of one particle-into-liquid sampler (PILS) coupled with a 250 cm path length liquid waveguide capillary cell (LWCC) and miniature fiber optic spectrometer, with detection wavelength set at 690 nm. The detection limit was 0.4 nM P, equivalent to 0.03 nmol P m(-3) in atmospheric particles...
July 19, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27286140/influence-of-atmospheric-processes-on-the-solubility-and-composition-of-iron-in-saharan-dust
#20
Amelia F Longo, Yan Feng, Barry Lai, William M Landing, Rachel U Shelley, Athanasios Nenes, Nikolaos Mihalopoulos, Kalliopi Violaki, Ellery D Ingall
Aerosol iron was examined in Saharan dust plumes using a combination of iron near-edge X-ray absorption spectroscopy and wet-chemical techniques. Aerosol samples were collected at three sites located in the Mediterranean, the Atlantic, and Bermuda to characterize iron at different atmospheric transport lengths and time scales. Iron(III) oxides were a component of aerosols at all sampling sites and dominated the aerosol iron in Mediterranean samples. In Atlantic samples, iron(II and III) sulfate, iron(III) phosphate, and iron(II) silicates were also contributors to aerosol composition...
July 5, 2016: Environmental Science & Technology
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