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https://www.readbyqxmd.com/read/29160722/do-infection-patterns-of-human-papillomavirus-affect-the-cytologic-detection-of-high-grade-cervical-lesions-on-papanicolaou-tests
#1
Siavash Azadmanesh Samimi, Roxanne R Mody, Steven Goodman, Eric Luna, Donna Armylagos, Mary R Schwartz, Dina R Mody, Yimin Ge
CONTEXT: - Persistent infection with high-risk human papillomavirus (hrHPV) is the major cause of cervical cancer. The effect of HPV infection patterns on cytologic detection of cervical lesions is unknown. OBJECTIVE: - To determine the effect of HPV infection patterns on the sensitivity of cytologic detection of high-grade cervical lesions. DESIGN: - Papanicolaou tests from 257 women with biopsy-confirmed, high-grade squamous intraepithelial lesions were analyzed with respect to HPV infection patterns...
November 21, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29159538/neuroinflammation-cortical-activity-and-fatiguing-behaviour-during-self-paced-exercise
#2
Nicole Vargas, Frank Marino
The present study aimed to identify whether or not the release of interleukin (IL)-6 and soluble (s) IL-6 receptor (R) is associated with fatiguing behaviour and changes in cortical activity during self-paced exercise. Relationships between the IL-6 and its soluble receptors, total work, reductions in power output, and changes in slow, alpha (α) and fast, beta (β) brain waves during self-paced exercise were evaluated. Different intensities and environments were used to manipulate the release of IL-6, whereby seven active males cycled for 60 min in heat stress (HS) or thermoneutral (TN) environments at a clamped rating of perceived exertion (RPE) equating to low intensity (RPE = 12) or high intensity (RPE = 16)...
November 20, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29158709/relationship-between-health-literacy-and-body-mass-index-among-arab-women-with-polycystic-ovary-syndrome
#3
Yazed Sulaiman Al-Ruthia, Bander Balkhi, Sultan AlGhadeer, Wael Mansy, Hisham AlSanawi, Reem AlGasem, Lama AlMutairi, Ibrahim Sales
Background: Polycystic ovary syndrome (PCOS) puts patients at higher risk for obesity and diabetes. Poor health literacy is also associated with these conditions. Notably, weight loss is associated with improved ovulation and pregnancy rates for women with PCOS. In this study the association between health literacy and body mass index (BMI) among women with PCOS was examined. Methods: The health literacy of women with PCOS was measured using the Arabic version of the single item literacy screener (SILS) at a university medical center...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29157669/the-combination-of-il-6-and-its-soluble-receptor-is-associated-with-the-response-of-rheumatoid-arthritis-patients-to-tocilizumab
#4
Cesar Diaz-Torne, Maria Dels Angels Ortiz, Patricia Moya, Maria Victoria Hernandez, Delia Reina, Ivan Castellvi, Juan Jose De Agustin, Diana de la Fuente, Hector Corominas, Raimon Sanmarti, Carlos Zamora, Elisabet Cantó, Silvia Vidal
BACKGROUND: IL-6 contributes significantly to the chronic inflammatory process of rheumatoid arthritis (RA). Tocilizumab, a humanized anti-human IL-6 receptor antibody that blocks the signaling originated by the IL-6/IL-6R complex, is an effective treatment. However, predictors of the response to tocilizumab are still required. We aimed to combine IL-6 and soluble IL-6R (sIL-6R) levels to identify groups of responses. METHODS: Heparinized blood and clinical data from 63 RA patients were collected before treatment and after 3 and 6 months...
November 17, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29156339/silicification-process-in-diatom-algae-using-different-silicon-chemical-sources-colloidal-silicic-acid-interactions-at-cell-surface
#5
Silvia Casabianca, Antonella Penna, Samuela Capellacci, Michela Cangiotti, Maria Francesca Ottaviani
The silicon transport and use inside cells are key processes for understanding how diatoms metabolize this element in the silica biogenic cycle in the ocean. A spin-probe electron paramagnetic resonance (EPR) study over time helped to investigate the interacting properties and the internalization mechanisms of silicic acid from different silicon sources into the cells. Diatom cells were grown in media containing biogenic amorphous substrates, such as diatomaceous earth and sponge spicules, and crystalline sodium metasilicate...
November 14, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29156139/thermo-sensitive-phase-separation-behavior-of-poly-benzyl-methacrylate-solvate-ionic-liquid-solutions
#6
Yumi Kobayashi, Yuzo Kitazawa, Kei Hashimoto, Takeshi Ueki, Hisashi Kokubo, Masayoshi Watanabe
We report a lower critical solution temperature (LCST) behavior of binary systems consisting of poly(benzyl methacrylate) (PBnMA) and solvate ionic liquids (SILs): equimolar mixtures of triglyme (G3) or tetraglyme (G4) and lithium bis(trifluoromethanesulfonyl)amide (Li[TFSA]). We evaluated the critical temperatures (Tcs) using transmittance measurements. The stability of the glyme-Li+ complex ([Li(G3 or G4)]+) in the presence of PBnMA was confirmed using Raman spectroscopy, pulsed-field gradient spin-echo NMR (PGSE-NMR), and thermogravimetric analysis to demonstrate that the complex was not disrupted...
November 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29154904/risk-of-upgrading-from-prostate-biopsy-to-radical-prostatectomy-pathology-does-saturation-biopsy-of-index-lesion-during-mpmri-trus-fusion-biopsy-help
#7
Brian P Calio, Abhinav Sidana, Dordaneh Sugano, Sonia Gaur, Mahir Maruf, Amit L Jain, Maria J Merino, Peter L Choyke, Bradford J Wood, Peter A Pinto, Baris Turkbey
PURPOSE: To determine if 'saturation' of the index-lesion during MRI-TRUS fusion-guided (fusion) biopsy decreases rate of pathological upgrade from biopsy to radical-prostatectomy (RP). MATERIALS/METHODS: A prospectively maintained single institution database was analyzed for patients who underwent both fusion and systematic biopsy followed by RP (2010-16). Index-lesion was defined as lesion with largest diameter on T2W-MRI. Patients with saturation of the index-lesion (SIL) had transrectal fusion biopsy targets obtained at 6mm intervals along the long axis of index-lesion; patients with nonsaturation of the index-lesion (NSIL) had only one target obtained from the lesion...
November 15, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29154448/significance-of-bizarre-cells-in-cervical-screening-liquid-based-cytology-a-prospective-study-of-15-cases
#8
O Ondič, R Ferko, J Kičinová, J Bouda, I Kinkorová-Luňáčková, L Kupcová, M Zůchová, J Chytra, T Waloschek, M Tůmová Bartošková, R Alaghehbandan, J Němcová
OBJECTIVE: The aim of this study was to assess the significance of bizarre cells (cells of squamous origin with a superficial squamous cell-type cytoplasm and characterised by multinucleation that produces bizarre nuclear shapes) in liquid-based cytology (LBC) Papanicoaou (pap) smears with clinical and histological follow-up correlation. METHODS: Fifteen patients, all with LBC samples containing bizarre cells, were identified in routine ThinPrep(®) LBC workload...
November 20, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29149736/graphene-oxide-reinforced-ionic-liquid-functionalized-adsorbent-for-solid-phase-extraction-of-phenolic-acids
#9
Xiudan Hou, Xiaofeng Lu, Sheng Tang, Licheng Wang, Yong Guo
An environmental friendly sorbent of polymeric ionic liquids modified graphene oxide-grafted silica (PILs@GO@Sil) was synthesized for solid-phase extraction (SPE) of phenolic acids. The sorbent was prepared via a chemical layer-to-layer fabrication including amidation reaction, surface radical chain-transfer polymerization and in situ anion exchange. After modification with PILs, the silica surface had higher positive potential so that it would exhibit stronger electrostatic interaction for acidic compounds compared with GO@Sil...
November 12, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29149625/the-effects-of-pre-and-post-slaughter-spray-application-with-organic-acids-on-microbial-population-reductions-on-beef-carcasses
#10
Hoa Van Ba, Hyun-Woo Seo, Seong Pil-Nam, Yoon-Seok Kim, Beom Young Park, Sung-Sil Moon, Se-Ju Kang, Yong-Min Choi, Jin-Hyoung Kim
As an attempt to control bacterial cross-contamination of beef carcasses, in the present investigation acetic acid and lactic acid (3% v/v) were used for bacterial decontamination. For the decontamination, cows were sprayed with each above acid at two different stages; (i) on live animal's hides, (ii) on carcass surfaces immediately after slaughter. Microbiological samples were taken on different hide areas of animals before spraying and on carcass surfaces at 24h after spraying. Meat quality traits were also analyzed on the sprayed animals...
November 6, 2017: Meat Science
https://www.readbyqxmd.com/read/29142240/robust-segmentation-of-the-full-cerebral-vasculature-in-4d-ct-of-suspected-stroke-patients
#11
Midas Meijs, Ajay Patel, Sil C van de Leemput, Mathias Prokop, Ewoud J van Dijk, Frank-Erik de Leeuw, Frederick J A Meijer, Bram van Ginneken, Rashindra Manniesing
A robust method is presented for the segmentation of the full cerebral vasculature in 4-dimensional (4D) computed tomography (CT). The method consists of candidate vessel selection, feature extraction, random forest classification and postprocessing. Image features include among others the weighted temporal variance image and parameters, including entropy, of an intensity histogram in a local region at different scales. These histogram parameters revealed to be a strong feature in the detection of vessels regardless of shape and size...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137072/volume-based-metabolic-parameter-of-breast-cancer-on-preoperative-18f-fdg-pet-ct-could-predict-axillary-lymph-node-metastasis
#12
Young-Sil An, Doo Kyoung Kang, Yongsik Jung, Tae Hee Kim
The purpose of our study was to evaluate the association between metabolic parameters on FDG PET/CT and axillary lymph node metastasis (ALNM) in patients with invasive breast cancer.From January 2012 to December 2012, we analyzed 173 patients with invasive ductal carcinoma (IDC) who underwent both initial breast magnetic resonance imaging (MRI) and F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) examinations. All metabolic parameters were measured from the tumor volume segmented by a gradient-based method...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29137009/brain-metabolism-in-patients-with-freezing-of-gait-after-hypoxic-ischemic-brain-injury-a-pilot-study
#13
Seo Yeon Yoon, Sang Chul Lee, Na Young Kim, Young-Sil An, Yong Wook Kim
Movement disorders are 1 of the long-term neurological complications that can occur after hypoxic-ischemic brain injury (HIBI). However, freezing of gait (FOG) after HIBI is rare. The aim of this study was to examine the brain metabolism of patients with FOG after HIBI using F-18 fluoro-2-deoxy-D-glucose positron emission tomography (F-18 FDG PET).We consecutively enrolled 11 patients with FOG after HIBI. The patients' overall brain metabolism was measured by F-18 FDG PET, and we compared their regional brain metabolic activity with that from 15 healthy controls using a voxel-by-voxel-based statistical mapping analysis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136620/use-of-automated-analysis-of-cervical-cytology-for-the-detection-of-high-grade-squamous-intraepithelial-lesions-in-human-papillomavirus-positive-women-a-future-practice
#14
Pierre Vassilakos, Rosa Catarino, Patrick Petignat
No abstract text is available yet for this article.
November 15, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/29136547/natural-products-used-as-a-chemical-library-for-protein-protein-interaction-targeted-drug-discovery
#15
Xuemei Jin, Kyungro Lee, Nam Hee Kim, Hyun Sil Kim, Jong In Yook, Jiwon Choi, Kyoung Tai No
Protein-protein interactions (PPIs), which are essential for cellular processes, have been recognized as attractive therapeutic targets. Therefore, the construction of a PPI-focused chemical library is an inevitable necessity for future drug discovery. Natural products have been used as traditional medicines to treat human diseases for millennia; in addition, their molecular scaffolds have been used in diverse approved drugs and drug candidates. The recent discovery of the ability of natural products to inhibit PPIs led us to use natural products as a chemical library for PPI-targeted drug discovery...
October 27, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29135515/association-between-allergic-and-nonallergic-rhinitis-and-obstructive-sleep-apnea
#16
Ming Zheng, Xiangdong Wang, Luo Zhang
PURPOSE OF REVIEW: Allergic rhinitis and nonallergic rhinitis (NAR) are common disorders, which have been considered as potential risk factors for obstructive sleep apnea (OSA). This review summarizes the proposed underlying pathophysiological mechanisms to provide a better understanding of the relationship between these conditions. RECENT FINDINGS: In adults, allergic rhinitis and NAR may be considered as symptoms potentiating, rather than risk potentiating factors in the pathophysiology of OSA, whereas in children, these are considered to be independent predictors for sleep-disordered breathing (SDB) and failure of adeno-tonsillectomy, the recommended first-line therapy for children with OSA...
November 14, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29134202/a-new-era-of-minimally-invasive-surgery-progress-and-development-of-major-technical-innovations-in-general-surgery-over-the-last-decade
#17
REVIEW
Manjunath Siddaiah-Subramanya, Kor Woi Tiang, Masimba Nyandowe
Minimally invasive surgery (MIS) continues to play an important role in general surgery as an alternative to traditional open surgery as well as traditional laparoscopic techniques. Since the 1980s, technological advancement and innovation have seen surgical techniques in MIS rapidly grow as it is viewed as more desirable. MIS, which includes natural orifice transluminal endoscopic surgery (NOTES) and single-incision laparoscopic surgery (SILS), is less invasive and has better cosmetic results. The technological growth and adoption of NOTES and SILS by clinicians in the last decade has however not been uniform...
October 2017: Surg J (N Y)
https://www.readbyqxmd.com/read/29133894/microalbuminuria-as-a-simple-predictor-of-incident-diabetes-over-8-years-in-the-korean-genome-and-epidemiology-study-koges
#18
Dong-Hyuk Jung, Young-Sup Byun, Yu-Jin Kwon, Gwang-Sil Kim
Microalbuminuria (MAU) is a common subclinical disease and related with cardiovascular outcome both in diabetic and non-diabetic patients. However, there is rare data about the effect of MAU on the development of diabetes. Thus, we aimed to investigate whether MAU is associated with the development of incident diabetes. A total of 3385 subjects without diabetes (1503 men and 1882 women; mean age, 53 years) who participated in the Ansung-Ansan cohort study from 2001-2002 (baseline) to 2011-2012 (fifth follow-up visit) were followed for a mean of 8 years...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29130974/atypical-squamous-cells-in-liquid-based-cervical-cytology-microbiology-inflammatory-infiltrate-and-human-papillomavirus-dna-testing
#19
Geilson Gomes de Oliveira, Renata Mirian Nunes Eleutério, Ana Katherine Silveira Gonçalves, Paulo César Giraldo, José Eleutério
OBJECTIVE: The aim of this study was to assess the correlation between atypical squamous cells (ASC) and inflammatory infiltrate and vaginal microbiota using cervical liquid-based cytological (SurePath®) and high-risk human papillomavirus (HR-HPV) tests. STUDY DESIGN: A cross-sectional study was conducted using a 6-year database from a laboratory in Fortaleza (Brazil). Files from 1,346 ASC cases were divided into subgroups and results concerning inflammation and vaginal microorganisms diagnosed by cytology were compared with HR-HPV test results...
November 8, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/29130075/association-between-cytokines-and-liver-histology-in-children-with-nonalcoholic-fatty-liver-disease
#20
Emily R Perito, Veeral Ajmera, Nathan M Bass, Philip Rosenthal, Joel E Lavine, Jeffrey B Schwimmer, Katherine P Yates, Anna Mae Diehl, Jean P Molleston, Karen F Murray, Ann Scheimann, Ryan Gill, David Glidden, Bradley Aouizerat
Background: Reliable non-invasive markers to characterize inflammation, hepatocellular ballooning, and fibrosis in nonalcoholic fatty liver disease (NAFLD) are lacking. We investigated the relationship between plasma cytokine levels and features of NAFLD histology to gain insight into cellular pathways driving NASH and to identify potential non-invasive discriminators of NAFLD severity and pattern. Methods: Cytokines were measured from plasma obtained at enrollment in pediatric participants in NASH Clinical Research Network studies with liver biopsy-proven NAFLD...
September 2017: Hepatol Commun
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