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https://www.readbyqxmd.com/read/28636739/a-comparison-of-tonsillar-surface-swabbing-fine-needle-aspiration-core-sampling-and-dissected-tonsillar-core-biopsy-culture-in-children-with-recurrent-tonsillitis
#1
Saurav Sarkar, Abheek Sil, Soma Sarkar, Biswajit Sikder
In recurrent tonsillitis, the pathogenic bacteria are harbored in the tonsil core, and therefore cultures of superficial swab samples are not particularly accurate in identifying specific types of core bacteria. On the other hand, the results of fine-needle aspiration (FNA) cultures of core samples have been closely correlated with the findings of core cultures in excised tonsils, and both methods are far superior to surface swabbing. We conducted a prospective study to compare the accuracy of culture findings from tonsillar tissue obtained by surface swabbing, FNA sampling of the tonsil core in situ, and core sampling of the excised tonsil in children with recurrent tonsillitis...
June 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28634419/elevated-plasma-levels-of-sil-2r-in-complex-regional-pain-syndrome-a-pathogenic-role-for-t-lymphocytes
#2
Krishna D Bharwani, Maaike Dirckx, Dirk L Stronks, Willem A Dik, Marco W J Schreurs, Frank J P M Huygen
The immune system has long been thought to be involved in the pathophysiology of complex regional pain syndrome (CRPS). However, not much is known about the role of the immune system and specifically T-cells in the onset and maintenance of this disease. In this study, we aimed to evaluate T-cell activity in CRPS by comparing blood soluble interleukin-2 receptor (sIL-2R) levels between CRPS patients and healthy controls. CRPS patients had statistically significant elevated levels of sIL-2R as compared to healthy controls (median sIL-2R levels: 4151 pg/ml (Q3 - Q1 = 5731 pg/ml - 3546 pg/ml) versus 1907 pg/ml (Q3 - Q1: 2206 pg/ml - 1374 pg/ml), p < 0...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28630024/proteolytic-control-of-interleukin-11-and-interleukin-6-biology
#3
REVIEW
Juliane Lokau, Maria Agthe, Charlotte M Flynn, Christoph Garbers
Interleukin-11 (IL-11) and IL-6 are secreted glycoproteins which fulfill important homeostatic functions. Activation of target cells occurs via membrane-bound IL-11 and IL-6 receptors (IL-11R and IL-6R, respectively). Formation of IL-11/IL-11R and IL-6/IL-6R complexes triggers the recruitment of a homodimer of the ubiquitously expressed signal-transducing β-receptor gp130 (classic signaling). IL-11R and IL-6R can be shed by several proteases, albeit with different preferences and specificities, and these soluble receptors (sIL-11R and sIL-6R) act as agonists and can activate in principle all cells via gp130...
June 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28629412/cross-cultural-validation-of-health-literacy-measurement-tools-in-italian-oncology-patients
#4
Paola Zotti, Simone Cocchi, Jerry Polesel, Chiara Cipolat Mis, Donato Bragatto, Silvio Cavuto, Alice Conficconi, Carla Costanzo, Melissa De Giorgi, Christina A Drace, Federica Fiorini, Laura Gangeri, Andrea Lisi, Rosalba Martino, Paola Mosconi, Angelo Paradiso, Valentina Ravaioli, Ivana Truccolo, Paolo De Paoli
BACKGROUND: The aim of this study was to assess the psychometric characteristics of four Health Literacy (HL) measurement tools, viz. Newest Vital Sign (NVS), Short Test of Functional Health Literacy in Adults (STOFHLA), Single Item Literacy Screener (SILS) and Single question on Self-rated Reading Ability (SrRA) among Italian oncology patients. METHODS: The original version of the tools were translated from the English language into Italian using a standard forward-backward procedure and according to internationally recognized good practices...
June 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28627606/effects-of-ischemic-preconditioning-on-pdgf-bb-expression-in-the-gerbil-hippocampal-ca1-region-following-transient-cerebral-ischemia
#5
Jae-Chul Lee, Yang Hee Kim, Tae-Kyeong Lee, In Hye Kim, Jeong Hwi Cho, Geum-Sil Cho, Bich-Na Shin, Joon Ha Park, Ji Hyeon Ahn, Myoung Cheol Shin, Jun Hwi Cho, Il Jun Kang, Moo-Ho Won, Jeong Yeol Seo
Ischemic preconditioning (IPC) is induced by exposure to brief durations of transient ischemia, which results in ischemic tolerance to a subsequent longer or lethal period of ischemia. In the present study, the effects of IPC (2 min of transient cerebral ischemia) were examined on immunoreactivity of platelet‑derived growth factor (PDGF)‑BB and on neuroprotection in the gerbil hippocampal CA1 region following lethal transient cerebral ischemia (LTCI; 5 min of transient cerebral ischemia). IPC was subjected to a 2‑min sublethal ischemia and a LTCI was given 5‑min transient ischemia...
June 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28626767/closer-to-a-uniform-language-in-colposcopy-study-on-the-potential-application-of-2011-international-federation-for-cervical-pathology-and-colposcopy-terminology-in-clinical-practice
#6
Yanyun Li, Xiaoling Duan, Long Sui, Fengying Xu, Shuifang Xu, Hongwei Zhang, Congjian Xu
As the newest colposcopic terminology, the 2011 International Federation for Cervical Pathology and Colposcopy (IFCPC) classification provides standardized interpretation of colposcopic findings. In this study, we analyzed the colposcopic accuracy and the significance of individual findings according to the 2011 IFCPC classification in 525 patients, reviewed by 13 trained colposcopists. Results show that colposcopic diagnoses are in 64.95% perfect agreement with cervical pathology, with 63.64% sensitivity and 96...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28623455/-single-incision-laparoscopy-current-status
#7
REVIEW
H Weiss, C Mittermair, M Weiss
BACKGROUND: Since the introduction of single incision laparoscopy (SIL), there has been disagreement among professional societies regarding a general recommendation for the use of this minimally invasive method. OBJECTIVES: Determination of evidence-based advantages of SIL compared to multiport laparoscopy (MPL). MATERIALS AND METHODS: Description of recent technical developments and evaluation of prospective randomized clinical trials and valid meta-analyses with regard to organ-specific procedures...
June 16, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28618867/human-articular-chondrocytes-induce-interleukin-2-nonresponsiveness-to-allogeneic-lymphocytes
#8
Satomi Abe, Hitoshi Nochi, Hiroshi Ito
Introduction We previously showed that articular chondrocytes (ACs) have immune privilege and immunomodulatory functions like those of mesenchymal stem cells. To elucidate these mechanisms, we focused on interleukin-2 (IL-2), which plays critical roles in lymphocyte mitogenic activity. The purpose of this study was to explore whether ACs affect the role of IL-2 underlying immunomodulatory functions. Material and Methods Irradiated human ACs from osteoarthritis donors were used. Third-party ACs were added to the mixed lymphocyte reaction (MLR) with or without recombinant human IL-2 (rhIL-2), and the levels of IL-2 and the soluble form of the IL-2 receptor α (sIL-2Rα) protein in supernatant were measured by enzyme-linked immunosorbent assay...
July 2017: Cartilage
https://www.readbyqxmd.com/read/28618339/hplc-ms-ms-method-for-troventol-determination-in-human-plasma-and-its-application-to-biological-samples
#9
Aleksandra Nikitina, Alexander Grigoriev, Alla Sidorova
For the first time, an HPLC-MS/MS method for the determination pmol/l levels of troventol (TRV) and clenbuterol as an internal standard (IS) in human plasma was developed, validated and tested on biological samples. The method included solid phase extraction by Waters Oasis WCX cartridges and chromatographic separation on a YMC-Pack SIL (100mm×2.1mm, 5μm, 12nm) analytical column with acetonitrile-water-formic acid (50:50:0.1, v/v/v) as the mobile phase; the selected ion transitions were m/z 332.2→138.2 and m/z 277...
April 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28606542/hydroxyapatite-crystallization-in-shrimp-cephalothorax-wastes-during-subcritical-water-treatment-for-chitin-extraction
#10
Angélica Espíndola-Cortés, Rosario Moreno-Tovar, Lauro Bucio, Miquel Gimeno, José Luis Ruvalcaba-Sil, Keiko Shirai
The extraction of calcareous chitin from shrimp cephalothorax was successfully achieved using a subcritical water treatment to attain a deproteinization up to 96%. The treatments also increased the crystalline domain size in the α-chitin fibers. An experimental design of Taguchi allowed the optimization of experiments. The macroelements identified in all samples were Ca, P, S, K, Cl and Al, whereas Cr, Mn, Fe, Ni, Cu, Zn, Br and Sr were also detected as microelements. The assigned crystalline phases by XRD were α-chitin, calcite, HAP and traces of quartz...
September 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28606225/-clinical-characteristics-and-prognostic-analysis-of-children-and-adolescents-over-10-years-of-age-with-acute-lymphoblastic-leukemia
#11
Jun Wu, Ai-Dong Lu, Le-Ping Zhang
OBJECTIVE: To explore the clinical characteristics and prognosis of children and adolescents over 10 years of age with acute lymphoblastic leukemia (ALL). METHODS: A total of 86 newly diagnosed ALL children and adolescents over 10 years of age (62 cases of B-ALL and 24 cases of T-ALL) were enrolled. Clinical characteristics, therapeutic effect and prognostic factors were retrospectively analyzed. Event-free survival (EFS) and overall survival (OS) rates were estimated by the Kaplan-Meier method...
June 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28606156/expression-of-mrna-il-17f-and-sil-17f-in-atopic-asthma-patients
#12
Mochammad Hatta, Eko E Surachmanto, Andi Asadul Islam, Syarifuddin Wahid
BACKGROUND: Asthma is a chronic inflammatory disorder of airway that involves many cells and elements. Chronic inflammation caused by increase Airway hyperresponsiveness that cause recurrent episodic symptoms of breathlessness, wheezing, chest tightness and coughing, especially at night or early morning. Interleukin 17F is a cytokine that plays an important role in the pathophysiology of asthma attacks. Some studies show a variety of IL-17F roles in the pathogenesis of airway inflammation due to an allergic reaction...
June 12, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28605400/proposed-terminology-for-anal-squamous-lesions-its-application-and-interobserver-agreement-among-pathologists-in-academic-and-community-hospitals
#13
Andres A Roma, Xiuli Liu, Deepa T Patil, Hao Xie, Daniela Allende
Objectives: To analyze interobserver reproducibility and compare practice patterns between academic and community settings of Lower Anogenital Squamous Terminology (LAST). Methods: In total, 132 anal biopsy slides were revised as well as p16 immunostains. Results: LAST was used in 49% of cases (academic center, 68%; satellite hospitals [community practice setting], 32%). After pathology review and consensus interpretation, 23 (17%) case diagnoses were reclassified: eight (34...
June 12, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28605192/absolute-protein-quantification-by-mass-spectrometry-not-as-simple-as-advertised
#14
Christopher M Shuford, James J Walters, Patricia M Holland, Uma Sreenivasan, Nadav Askari, Kevin B Ray, Russell P Grant
Stable-isotope labeled (SIL) tryptic peptides, cleavable SIL peptides, and a full-length SIL protein were compared for internal calibration (i.e., as internal calibrators) and external calibration (i.e., as internal standards) when quantifying three forms of unlabeled, human thyroglobulin (Tg) by bottom-up protein analysis. All SIL materials and human proteins were standardized by amino acid analysis to ensure traceability of measurements and allow confident assignment of accuracy. The three forms of human Tg quantified were 1) the primary reference material BCR®457 - a native protein purified from human thyroids - 2) a commercially available form also purified from human thyroids, and 3) a full-length recombinant form expressed and purified from a human embryonic kidney 293 cell-line...
June 12, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28604377/minimally-invasive-distal-pancreatectomy-a-retrospective-review-of-30-cases
#15
Aziz Su Mer, Umut Barbaros, Salvador Morales Conde, Sebahattin Celik, Nihat Aksakal, Jose Maria Alamo, Isaias Alarcon, Nazim Gu Res, Hamit Karayagiz, Ahmet Dinccag, Ridvan Seven, Selcuk Mercan, Demir Budak
OBJECTIVES: Pancreatic surgery has been greatly influenced by the advent of laparoscopic surgery and increasing experience in its performance and by advances in techniques and surgical devices. This study aimed to represent two centers' initial experiences in laparoscopic distal pancreatic surgery. METHODS: This study was a bi-centric study including 30 patients undergoing distal pancreatectomy for pancreatic disorders. All the patients were operated on from November 2006 to November 2013 in Turkey and Spain...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28603542/-low-grade-squamous-intraepithelial-lesion-cannot-exclude-high-grade-tbs-says-don-t-use-it-should-i-really-stop-it
#16
Jeanine M Chiaffarano, Melissa Alexander, Robert Rogers, Fang Zhou, Joan Cangiarella, Melissa Yee-Chang, Paul Elgert, Aylin Simsir
BACKGROUND: The Bethesda System uses a two-tiered approach in the diagnosis of cervical squamous intraepithelial lesions (SILs). Occasionally, Papanicolaou (Pap) tests with evident low-grade SIL (LSIL) also have some features suggestive but not diagnostic of high-grade SIL (HSIL). This study reviews our experience with "Low-grade Squamous Intraepithelial Lesion, Cannot Exclude High-grade" (LSIL-H) and discusses the best approach to report such Paps if the LSIL-H interpretation is abandoned...
2017: CytoJournal
https://www.readbyqxmd.com/read/28603026/widespread-reduction-of-dopamine-cell-bodies-and-terminals-in-adult-rats-exposed-to-a-low-dose-regimen-of-mdma-during-adolescence
#17
Cristina Cadoni, Augusta Pisanu, Nicola Simola, Lucia Frau, Pier Francesca Porceddu, Silvia Corongiu, Christian Dessì, Annesha Sil, Antonio Plumitallo, Jadwiga Wardas, Gaetano Di Chiara
Although MDMA (3,4-methylendioxymethamphetamine, ecstasy) neurotoxicity in serotonin neurons is largely recognized in a wide variety of species including man, neurotoxicity in dopamine (DA) neurons is thought to be species-specific. MDMA is mainly consumed by adolescents, often in conjunction with caffeine (Energy Drinks) and this association has been reported to exacerbate MDMA toxic effects. In order to model these aspects of MDMA use, vis-à-vis their impact on DA neurons, we investigated the effects of adolescent exposure to low doses of MDMA (5 mg/kg for 10 days), alone or in combination with caffeine (10 mg/kg) on neuronal and functional DA indices and on recognition memory in adult rats...
June 8, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28601686/exaggerated-t-follicular-helper-cell-responses-in-lrba-deficiency-due-to-failure-of-ctla4-mediated-regulation
#18
Fayhan J Alroqi, Louis-Marie Charbonnier, Safa Baris, Ayca Kiykim, Janet Chou, Craig D Platt, Abdulrahman Algassim, Sevgi Keles, Bandar K Al Saud, Fowzan S Alkuraya, Michael Jordan, Raif S Geha, Talal A Chatila
PURPOSE: LRBA (lipopolysaccharide-responsive beige like anchor protein) and CTLA4 (cytotoxic T lymphocyte antigen 4) deficiencies give rise to overlapping phenotypes of immune dysregulation and autoimmunity, with dramatically increased frequencies of circulating T Follicular helper (cTFH) cells. We sought to determine the mechanisms of cTFH cell dysregulation in LRBA deficiency and the utility of monitoring cTFH cells as a correlate of clinical response to CTLA4-Ig therapy. METHODS: cTFH cells and other lymphocyte subpopulations were characterized...
June 7, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28601027/a-semantic-interoperability-approach-to-support-integration-of-gene-expression-and-clinical-data-in-breast-cancer
#19
Raul Alonso-Calvo, Sergio Paraiso-Medina, David Perez-Rey, Enrique Alonso-Oset, Ruud van Stiphout, Sheng Yu, Marian Taylor, Francesca Buffa, Carlos Fernandez-Lozano, Alejandro Pazos, Victor Maojo
INTRODUCTION: The introduction of omics data and advances in technologies involved in clinical treatment has led to a broad range of approaches to represent clinical information. Within this context, patient stratification across health institutions due to omic profiling presents a complex scenario to carry out multi-center clinical trials. METHODS: This paper presents a standards-based approach to ensure semantic integration required to facilitate the analysis of clinico-genomic clinical trials...
June 5, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28598779/preclinical-biomarker-associations-with-both-incident-rheumatoid-arthritis-and-its-subsequent-mortality-sex-effects-in-a-41-year-community-based-case-control-cohort-study
#20
Alfonse T Masi, Azeem A Rehman, Laura C Jorgenson, Jean C Aldag
OBJECTIVES: To identify sex effects and preclinical serum biomarker associations with both incident rheumatoid arthritis (RA) and its subsequent mortality, using a 41-year, community-based, case-control cohort. METHODS: After cohort entry in 1974, incident RA cases (n=54) had clinical onsets between 1977 and 1994. Cohort control (CN) subjects were individually matched on entry to cases (4 CN:1 RA, n=216). All subjects were followed for survival from 1995 through 2015...
June 5, 2017: Clinical and Experimental Rheumatology
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