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https://www.readbyqxmd.com/read/28107907/a-new-route-for-synthesis-of-n-methylimidazolium-grafted-silica-stationary-phase-and-reevaluation-in-hydrophilic-interaction-liquid-chromatography
#1
Houmei Liu, Jia Chen, Zhan Li, Makoto Takafuji, Hirotaka Ihara, Hongdeng Qiu
In this work, a "solvent-free" and green method for controllable and quantitative preparation of chromatographic stationary phase has been proposed. About the method, the largely excess of functional monomer and strict control of the proportion between silane and silica are the two most important points. Due to the existence of excessive functional monomer, silane can be utilized at the maximum extent, thereby achieving quantitative and reproducible bonding. Meanwhile, the excessive monomer can also be well recycled...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28105550/stable-isotope-labeling-for-improved-comparative-analysis-of-rna-digests-by-mass-spectrometry
#2
Mellie June Paulines, Patrick A Limbach
Even with the advent of high throughput methods to detect modified ribonucleic acids (RNAs), mass spectrometry remains a reliable method to detect, characterize, and place post-transcriptional modifications within an RNA sequence. Here we have developed a stable isotope labeling comparative analysis of RNA digests (SIL-CARD) approach, which improves upon the original (18)O/(16)O labeling CARD method. Like the original, SIL-CARD allows sequence or modification information from a previously uncharacterized in vivo RNA sample to be obtained by direct comparison with a reference RNA, the sequence of which is known...
January 19, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28103144/role-of-different-natural-antioxidants-in-the-modulation-of-mrna-expression-of-apoptotic-molecules-in-the-livers-of-carbon-tetrachloride-intoxicated-rats
#3
Nouf M Al-Rasheed, Naglaa F El-Orabi, Laila Mohamed Fadda, Hanaa Mahmoud Ali, Nawal M Al-Rasheed, Yieldez Bassiouni, Abeer Mohammad Aldbass
Overexpression of nuclear factor (NF-κB) or activation of Smad3 by transforming growth factor β (TGF-β1) induced by oncogenes results in overexpression of fibrotic processes and hence cell death. The objective of this study is to examine whether Silymarin (Sil) alone or in combination with Vitamin E (Vit E) and/or Curcumin (Cur) plays a modulatory role against the overexpression of NF-κB, and TGF-β that induced in response to carbon tetrachloride (CCl4) administration. The present work revealed that CCl4 induced elevation of in serum alanine aminotransferase (ALT), Apoptosis regulator (Bax), Smad3, TGF-β, and NF-kB hepatic mRNA expression (using Real-time PCR), administration of Sil alone downregulated these expressions...
January 19, 2017: Animal Biotechnology
https://www.readbyqxmd.com/read/28099142/the-pentapeptide-gly-thr-gly-lys-thr-confers-sensitivity-to-anti-cancer-drugs-by-inhibition-of-cage-binding-to-gsk3%C3%AE-and-decreasing-the-expression-of-cyclind1
#4
Youngmi Kim, Hyuna Kim, Deokbum Park, Hansoo Lee, Yun Sil Lee, Jongseon Choe, Young Myeong Kim, Doyong Jeon, Dooil Jeoung
We previously reported the role of cancer/testis antigen CAGE in the response to anti-cancer drugs. CAGE increased the expression of cyclinD1, and pGSK3βSer9, an inactive GSK3β, while decreasing the expression of phospho-cyclinD1Thr286. CAGE showed binding to GSK3β and the domain of CAGE (amino acids 231-300) necessary for binding to GSK3β and for the expression regulation of cyclinD1 was determined. 269GTGKT273 peptide, corresponding to the DEAD box helicase domain of CAGE, decreased the expression of cyclinD1 and pGSK3βSer9 while increasing the expression of phospho-cyclinD1Thr286...
January 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28096363/an-rna-based-signature-enables-high-specificity-detection-of-circulating-tumor-cells-in-hepatocellular-carcinoma
#5
Mark Kalinich, Irun Bhan, Tanya T Kwan, David T Miyamoto, Sarah Javaid, Joseph A LiCausi, John D Milner, Xin Hong, Lipika Goyal, Srinjoy Sil, Melissa Choz, Uyen Ho, Ravi Kapur, Alona Muzikansky, Huidan Zhang, David A Weitz, Lecia V Sequist, David P Ryan, Raymond T Chung, Andrew X Zhu, Kurt J Isselbacher, David T Ting, Mehmet Toner, Shyamala Maheswaran, Daniel A Haber
Circulating tumor cells (CTCs) are shed into the bloodstream by invasive cancers, but the difficulty inherent in identifying these rare cells by microscopy has precluded their routine use in monitoring or screening for cancer. We recently described a high-throughput microfluidic CTC-iChip, which efficiently depletes hematopoietic cells from blood specimens and enriches for CTCs with well-preserved RNA. Application of RNA-based digital PCR to detect CTC-derived signatures may thus enable highly accurate tissue lineage-based cancer detection in blood specimens...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28092576/multiple-instance-learning-for-medical-image-and-video-analysis
#6
Gwenole Quellec, Guy Cazuguel, Beatrice Cochener, Mathieu Lamard
Multiple-Instance Learning (MIL) is a recent machine learning paradigm that is particularly well suited to Medical Image and Video Analysis (MIVA) tasks. Based solely on class labels assigned globally to images or videos, MIL algorithms learn to detect relevant patterns locally in images or videos. These patterns are then used for classification at a global level. Because supervision relies on global labels, manual segmentations are not needed to train MIL algorithms, unlike traditional Single-Instance Learning (SIL) algorithms...
January 10, 2017: IEEE Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/28091842/squamous-cell-dysplasia-in-the-proximal-rectum-of-three-patients-treated-for-ulcerative-colitis-on-immunomodulators
#7
James G Connolly, Stephen E Goldstone
BACKGROUND: Anal canal high-grade squamous intraepithelial lesion (HSIL) is the precursor to anal cancer. Immunocompromised patients are at increased risk and disease is usually within 3 cm from the anal verge. High-resolution anoscopy (HRA) with an 8-cm anoscope is used to identify and guide cautery treatment of HSIL. PURPOSE: We report three patients with a long-term history of ulcerative colitis (UC) treated with systemic immunomodulators who developed proximally located rectal HSIL...
January 13, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28091444/impact-of-visual-inspection-with-acetic-acid-plus-cryotherapy-see-and-treat-approach-on-the-reduction-of-the-population-burden-of-cervical-preinvasive-lesions-in-southeast-nigeria
#8
C O Chigbu, A K Onyebuchi, E F Nnakenyi, C C Egbuji
OBJECTIVE: The aim of this study is to determine the impact of visual inspection with acetic acid (VIA) plus immediate cryotherapy on the prevalence of VIA-detected cervical squamous intraepithelial lesion (SIL). METHODS: Women in four rural communities in Southeast Nigeria were screened with VIA. Women who tested positive to VIA were offered either immediate cryotherapy or large loop excision of the transformation zone based on predetermined eligibility criteria...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28078828/biomarkers-upon-discontinuation-of-renal-replacement-therapy-predict-60-day-survival-and-renal-recovery-in-critically-ill-patients-with-acute-kidney-injury
#9
Tingting Yang, Si Sun, Yuliang Zhao, Qiang Liu, Mei Han, Liping Lin, Baihai Su, Songmin Huang, Lichuan Yang
Introduction There is no consensus on the specific indications for weaning critically ill patients with acute kidney injury (AKI) off renal replacement therapy (RRT). This study aimed to explore the prognostic value of several biomarkers measured upon discontinuation of RRT for their value in predicting 60-day survival and renal recovery in an effort to add knowledge to the decision-making process regarding RRT withdrawal. Methods We prospectively enrolled 102 patients with AKI who required RRT from the intensive care unit...
January 11, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28075620/diagnostic-efficacy-of-structural-mri-in-patients-with-mild-to-moderate-alzheimer-disease-automated-volumetric-assessment-versus-visual-assessment
#10
Jeeyoung Min, Won-Jin Moon, Ji Young Jeon, Jin Woo Choi, Yeon-Sil Moon, Seol-Heui Han
OBJECTIVE: The purpose of this study was to compare the diagnostic efficacies of an automated volumetric assessment tool and visual assessment in the evaluation of medial temporal lobar atrophy in mild-to-moderate Alzheimer disease (AD). MATERIALS AND METHODS: This retrospective study included 30 patients with mild-to-moderate AD and 25 age-matched healthy control subjects undergoing MRI with a 3D fast spoiled gradient recalled-echo sequence at 3 T. The images were processed with fully automated volumetric analysis software...
January 11, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28069386/sleep-influences-the-immune-response-and-the-rejection-process-alters-sleep-pattern-evidence-from-a-skin-allograft-model-in-mice
#11
Francieli Silva Ruiz, Monica Levy Andersen, Camila Guindalini, Leandro Pires Araujo, José Daniel Lopes, Sergio Tufik
INTRODUCTION: Sleep generally regulates immune functions in a supportive manner and can affect parameters that are directly involved in the rejection process. STUDY OBJECTIVES: The first objective was to assess whether sleep deprivation (SD) or sleep restriction (SR) affects the allograft rejection process in mice. The second objective was to investigate whether the rejection process itself modulates the sleep pattern of allografted mice. DESIGN: Adult BALB/c and C57BL/6J male mice were used as the donors and recipients, respectively, except for the syngeneic group (ISOTX), which received skin from mice of the same strain (C57BL/6J)...
January 6, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28068086/enhanced-lithium-ion-transport-in-poly-ethylene-glycol-diacrylate-supported-solvate-ionogel-electrolytes-via-chemically-cross-linked-ethylene-oxide-pathways
#12
Anthony J D'Angelo, Matthew J Panzer
Lithium-ion solvate ionic liquids (SILs), consisting of complexed Li(+) cations and a weakly basic anion, represent an emergent class of nonvolatile liquid electrolytes suitable for lithium-based electrochemical energy storage. In this report, solid-state, flexible solvate ionogel electrolytes are synthesized via UV-initiated free radical polymerization/cross-linking of poly(ethylene glycol) diacrylate (PEGDA) in situ within the [Li(G4)][TFSI] electrolyte, which is formed by an equimolar mixture of lithium bis(trifluoromethylsulfonyl)imide (LiTFSI) and tetraglyme (G4)...
January 9, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28065581/nitric-oxide-synthase-inhibitor-aminoguanidine-reduces-intracerebroventricular-colchicine-induced-neurodegeneration-memory-impairments-and-changes-of-systemic-immune-responses-in-rats
#13
Susmita Sil, Tusharkanti Ghosh, Rupsa Ghosh, Pritha Gupta
Intracerebroventricular (i.c.v.) injection of colchicine induces neurodegeneration, memory impairments and changes of some systemic immune responses in rats. Though the role of cox 2 in these colchicine induced changes have been evaluated, the influence of nitric oxide synthase (NOS) remains to be studied. The present study was designed to assess the role of NOS on the i.c.v. colchicine induced neurodegeneration, memory impairments and changes of some systemic immune responses by inhibiting its activity with aminoguanidine...
December 13, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28060820/proteolytic-origin-of-the-soluble-human-il-6r-in-vivo-and-a-decisive-role-of-n-glycosylation
#14
Steffen Riethmueller, Prasath Somasundaram, Johanna C Ehlers, Chien-Wen Hung, Charlotte M Flynn, Juliane Lokau, Maria Agthe, Stefan Düsterhöft, Yijue Zhu, Joachim Grötzinger, Inken Lorenzen, Tomas Koudelka, Kosuke Yamamoto, Ute Pickhinke, Rielana Wichert, Christoph Becker-Pauly, Marisa Rädisch, Alexander Albrecht, Markus Hessefort, Dominik Stahnke, Carlo Unverzagt, Stefan Rose-John, Andreas Tholey, Christoph Garbers
Signaling of the cytokine interleukin-6 (IL-6) via its soluble IL-6 receptor (sIL-6R) is responsible for the proinflammatory properties of IL-6 and constitutes an attractive therapeutic target, but how the sIL-6R is generated in vivo remains largely unclear. Here, we use liquid chromatography-mass spectrometry to identify an sIL-6R form in human serum that originates from proteolytic cleavage, map its cleavage site between Pro-355 and Val-356, and determine the occupancy of all O- and N-glycosylation sites of the human sIL-6R...
January 2017: PLoS Biology
https://www.readbyqxmd.com/read/28057941/combining-in-situ-lithography-with-3d-printed-solid-immersion-lenses-for-single-quantum-dot-spectroscopy
#15
Marc Sartison, Simone Luca Portalupi, Timo Gissibl, Michael Jetter, Harald Giessen, Peter Michler
In the current study, we report on the deterministic fabrication of solid immersion lenses (SILs) on lithographically pre-selected semiconductor quantum dots (QDs). We demonstrate the combination of state-of-the-art low-temperature in-situ photolithography and femtosecond 3D direct laser writing. Several QDs are pre-selected with a localization accuracy of less than 2 nm with low-temperature lithography and three-dimensional laser writing is then used to deterministically fabricate hemispherical lenses on top of the quantum emitter with a submicrometric precision...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28057317/factors-influencing-emergency-nurses-burnout-during-an-outbreak-of-middle-east-respiratory-syndrome-coronavirus-in-korea
#16
Ji Soo Kim, Jeong Sil Choi
PURPOSE: Emergency department (ED) nurses suffer from persistent stress after experiencing the traumatic event of exposure to Middle East respiratory syndrome coronavirus (MERS-CoV), which can subsequently lead to burnout. This study aimed to assess ED nurses' burnout level during an outbreak of MERS-CoV and to identify influencing factors in order to provide basic information for lowering and preventing the level of burnout. METHODS: Study participants were ED nurses working in eight hospitals designated for treating MERS-CoV-infected patients in Korea...
December 2016: Asian Nursing Research
https://www.readbyqxmd.com/read/28052328/type-dependent-association-between-risk-of-cervical-intraepithelial-neoplasia-and-viral-load-of-oncogenic-human-papillomavirus-types-other-than-types-16-and-18
#17
Long Fu Xi, Mark Schiffman, Yang Ke, James P Hughes, Denise A Galloway, Zhonghu He, Ayaka Hulbert, Rachel L Winer, Laura A Koutsky, Nancy B Kiviat
Studies of the clinical relevance of human papillomavirus (HPV) DNA load have focused mainly on HPV16 and HPV18. Data on other oncogenic types are rare. Study subjects were women enrolled in the Atypical Squamous Cells of Undetermined Significance (ASC-US) and Low-Grade Squamous Intraepithelial Lesion (LSIL) Triage Study who had ≥1 of 11 non-HPV16/18 oncogenic types detected during a 2-year follow-up at 6-month intervals. Viral load measurements were performed on the first type-specific HPV-positive specimens...
January 4, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28040505/dlg1-polarity-protein-expression-associates-with-the-disease-progress-of-low-grade-cervical-intraepithelial-lesions
#18
Ana Laura Cavatorta, Alejandra Di Gregorio, Marina Bugnon Valdano, Federico Marziali, Mariela Cabral, Hebe Bottai, Jorge Cittadini, Ana Lia Nocito, Daniela Gardiol
Human Discs large tumour suppressor (DLG1) participates in regulating cell polarity and proliferation, suggesting an important connection between epithelial organization and cellular growth control. However, it was demonstrated that DLG1 could acquire oncogenic attributes in some specific contexts. In this work, we evaluated the expression of DLG1 and its contribution to the progress of cervical lesions in order to investigate a potential role of this polarity protein in human oncogenic processes. We analyzed cervical biopsies from women with low-grade squamous intraepithelial lesion (LSIL) diagnosis (n=30), for DLG1 expression by immunohistochemistry...
December 29, 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28039295/third-generation-cd28-4-1bb-chimeric-antigen-receptor-t-cells-for-chemotherapy-relapsed-or-refractory-acute-lymphoblastic-leukaemia-a-non-randomised-open-label-phase-i-trial-protocol
#19
Xiao-Yi Tang, Yao Sun, Ang Zhang, Guo-Liang Hu, Wei Cao, Dan-Hong Wang, Bin Zhang, Hu Chen
INTRODUCTION: There is no curative treatment available for patients with chemotherapy relapsed or refractory CD19+ B cells-derived acute lymphoblastic leukaemia (r/r B-ALL). Although CD19-targeting second-generation (2nd-G) chimeric antigen receptor (CAR)-modified T cells carrying CD28 or 4-1BB domains have demonstrated potency in patients with advanced B-ALL, these 2 signalling domains endow CAR-T cells with different and complementary functional properties. Preclinical results have shown that third-generation (3rd-G) CAR-T cells combining 4-1BB and CD28 signalling domains have superior activation and proliferation capacity compared with 2nd-G CAR-T cells carrying CD28 domain...
December 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/28038710/differentiated-squamous-intraepithelial-lesion-dsil-like-changes-in-the-epidermis-overlying-anogenital-melanocytic-nevi-a-diagnostic-pitfall
#20
Kvetoslava Michalova, Dmitry V Kazakov, Michael Michal, Ladislav Hadravsky, Denisa Kacerovska, Boris Rychly, Marketa Miesbauerova, Michal Michal
BACKGROUND: Differentiated squamous intraepithelial lesion (dSIL) is morphologically and immunohistochemically analogous in the whole anogenital region. dSIL is a premalignant lesion frequently misinterpreted histopathologically as a benign dermatosis. The authors describe a peculiar change in the basal cell layer of the epidermis/epithelium overlying anogenital melanocytic nevi that may histopathologically imitate dSIL. The aim of this study is to familiarize the pathologists with this pitfall to avoid its possible overdiagnosis as dysplasia...
February 2017: Annals of Diagnostic Pathology
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