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Epilepsy in children

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https://www.readbyqxmd.com/read/29353090/investigating-the-prevalence-of-febrile-convulsion-in-kayseri-turkey-an-assessment-of-the-risk-factors-for-recurrence-of-febrile-convulsion-and-for-development-of-epilepsy
#1
Mehmet Canpolat, Huseyin Per, Hakan Gumus, Ferhan Elmali, Sefer Kumandas
PURPOSE: The purpose of this study was to investigate the prevalence and recurrence of febrile convulsion (FC) and risk factors for development of epilepsy in school children throughout in the Kayseri provincial center. METHOD: Ten thousand individuals selected using "stratified cluster sampling" from a student population of 259,428 inside the Kayseri Urban Municipality represented the study sample. Fifteen thousand questionnaires were distributed, of which 10,742 (71...
January 10, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29352627/indications-and-limits-of-stereoelectroencephalography-seeg
#2
REVIEW
Lorella Minotti, Alexandra Montavont, Julia Scholly, Louise Tyvaert, Delphine Taussig
Epilepsy surgery is now an accepted treatment to achieve seizure control in carefully selected patients, both children and adults, suffering from drug-resistant focal epilepsy. Although surgical strategies can often be defined on the basis of non-invasive diagnostic procedures, and despite the recent advances in this field, an increasing number of more complex cases requires invasive EEG (iEEG) to provide precise information on the localization of the epileptogenic zone (EZ), its relationships with eloquent cortex (EC), and the feasibility of a tailored surgical resection...
January 15, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29350262/vagal-nerve-stimulation-for-medically-refractory-epilepsy-in-angelman-syndrome-a-series-of-three-cases
#3
REVIEW
Krystal L Tomei, Christine Y Mau, Michael Ghali, Jayoung Pak, Ira M Goldstein
BACKGROUND: We describe three children with Angelman syndrome and medically refractory epilepsy. METHODS: Case series of three pediatric patients with Angelman syndrome and medically refractory epilepsy. All three patients failed medical treatment and were recommended for vagal nerve stimulator (VNS) implantation. RESULTS: Following VNS implantation, all three patients experienced reduction in seizure frequency greater than that afforded by medication alone...
January 19, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29344467/longitudinal-change-in-thyroid-hormone-levels-in-children-with-epilepsy-on-a-ketogenic-diet-prevalence-and-risk-factors
#4
Yun-Jin Lee, Sang Ook Nam, Kyung-Min Kim, Young Mi Kim, Gyu Min Yeon
Background and Purpose: The aim of this study is to evaluate the prevalence of hypothyroidism and the change of thyroid hormone level in the children with epilepsy on a ketogenic diet (KD). Methods: The levels of serum free thyroxine (fT4) and thyroid-stimulation hormone (TSH) were measured at the start of the KD and at 6- to 12-month intervals in children with intractable epilepsy. Hypothyroidism was defined as fT4 level < 0.8 ng/dL and TSH level > 6.0 μIU/mL...
December 2017: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/29344464/cannabinoids-in-the-treatment-of-epilepsy-hard-evidence-at-last
#5
REVIEW
Emilio Perucca
The interest in cannabis-based products for the treatment of refractory epilepsy has skyrocketed in recent years. Marijuana and other cannabis products with high content in Δ(9) - tetrahydrocannabinol (THC), utilized primarily for recreational purposes, are generally unsuitable for this indication, primarily because THC is associated with many undesired effects. Compared with THC, cannabidiol (CBD) shows a better defined anticonvulsant profile in animal models and is largely devoid of adverse psychoactive effects and abuse liability...
December 2017: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/29342997/-x-linked-inhibitor-of-apoptosis-deficiency-manifested-as-crohn-s-disease-a-case-report-and-literature-review
#6
L J Xu, Y Y Luo, J D Yu, J G Lou, Y H Fang, J Chen
Objective: To analyze the clinical characteristics of X-linked inhibitor of apoptosis (XIAP) deficient patients with clinical manifestation of Crohn's disease. Methods: Clinical manifestations, laboratory investigations, genetic testing and therapeutic interventions of one case of XIAP deficiency who was admitted to Department of Gastroenterology in Children's Hospital, Zhejiang University School of Medicine in May 2016 were summarized. PubMed and Chinese database for articles published from January 2016 to June 2017 were searched using the key words of'Crohn's disease'and'XIAP', and the relevant literature was reviewed...
January 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29341053/-the-use-of-anticonvulsants-and-the-levels-of-folate-vitamin-b12-and-homocysteine
#7
D Dinç, P F J Schulte
BACKGROUND Patients with epilepsy who use anticonvulsants frequently show low levels of folate and vitamin B12 and high levels of homocysteine. Patients with bipolar disorder use some anticonvulsants as mood stabilisers.<br/> AIM: To determine whether some anticonvulsants lower folate and vitamin B12 and raise homocysteine levels.<br/> METHOD: Systematic literature search to determine the relation between the anticonvulsants valproic acid, carbamazepine, lamotrigine and topiramate on the one hand and blood levels of folate, vitamin B12 and homocysteine on the other hand...
2018: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29325826/myoclonic-absence-seizures-with-complex-gestural-automatisms
#8
Kenneth A Myers, Ingrid E Scheffer
Epilepsy with myoclonic absences is a rare generalized epilepsy syndrome with distinctive seizures. Two unrelated children had mild developmental impairment and onset of myoclonic-absences at 3 and 8 years. Seizures were characterized by bilateral 3 Hz myoclonic jerks superimposed on tonic abduction of the upper limbs. Events lasted 10-60 s, and complex gestural automatisms were often observed; in one case, a boy undid his seatbelt and attempted to exit a moving vehicle. Post-ictally, both children immediately regained awareness without recollection of their actions...
December 19, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29320603/drug-management-for-acute-tonic-clonic-convulsions-including-convulsive-status-epilepticus-in-children
#9
REVIEW
Amy McTague, Timothy Martland, Richard Appleton
BACKGROUND: Tonic-clonic convulsions and convulsive status epilepticus (currently defined as a tonic-clonic convulsion lasting at least 30 minutes) are medical emergencies and require urgent and appropriate anticonvulsant treatment. International consensus is that an anticonvulsant drug should be administered for any tonic-clonic convulsion that has been continuing for at least five minutes. Benzodiazepines (diazepam, lorazepam, midazolam) are traditionally regarded as first-line drugs and phenobarbital, phenytoin and paraldehyde as second-line drugs...
January 10, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29318927/cost-effectiveness-of-evaluation-of-children-with-epilepsy-in-the-emergency-department-need-for-investment-in-patient-education
#10
Karen S Carvalho, Anthony L Fine, Christopher J Haines, Ignacio Valencia, Divya S Khurana, Agustin Legido
We aimed to study cost-effectiveness of seizure evaluation of children with epilepsy in the emergency department (ED). We reviewed epilepsy patients seen at our ED for 1 year. Age, laboratory and neuroimaging results, treatment, disposition, and usefulness of the visit (need for hospitalization, clinical improvement) were analyzed. We identified 330 patients, aged 23 days-21 years, 190 (57.5%) had blood tests, 45 (13.6%) urinalysis, 2 (0.6%) cerebrospinal fluid testing, and 44 neuroimaging studies (13.3%)...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29315516/strong-coupling-between-slow-oscillations-and-wide-fast-ripples-in-children-with-epileptic-spasms-investigation-of-modulation-index-and-occurrence-rate
#11
Yasushi Iimura, Kevin Jones, Lynne Takada, Itsuki Shimizu, Misaki Koyama, Kyoko Hattori, Yushi Okazawa, Yutaka Nonoda, Eishi Asano, Tomoyuki Akiyama, Cristina Go, Ayako Ochi, O Carter Snead, Elizabeth J Donner, James T Rutka, James M Drake, Hiroshi Otsubo
OBJECTIVE: Epileptic spasms (ES) often become drug-resistant. To reveal the electrophysiological difference between children with ES (ES+) and without ES (ES-), we compared the occurrence rate (OR) of high-frequency oscillations (HFOs) and the modulation index (MI) of coupling between slow and fast oscillations. In ES+, we hypothesized that (1) pathological HFOs are more widely distributed and (2) slow oscillations show stronger coupling with pathological HFOs than in ES-. METHODS: We retrospectively reviewed 24 children with drug-resistant multilobar onset epilepsy, who underwent intracranial video electroencephalography prior to multilobar resections...
January 6, 2018: Epilepsia
https://www.readbyqxmd.com/read/29315089/high-amplitude-background-slow-waves-in-normal-children-aged-3-to-18-months-implications-for-the-consideration-of-hypsarhythmia
#12
John R Mytinger, Amanda Weber, Jorge Vidaurre
PURPOSE: To assess for the presence of high amplitude EEG background slow waves in normal young children. METHODS: One hundred children with normal development ages 3 to 18 months had normal EEGs for spells and did not have seizures or epilepsy. Three electroencephalographers retrospectively reviewed 5 minutes of stable stage II sleep to measure background slow waves for peak-to-peak amplitudes. A standard 10-20 longitudinal bipolar montage was used. Interrater agreement was assessed by intraclass correlation coefficient...
January 8, 2018: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/29313968/cochrane-systematic-review-and-meta-analysis-of-the-impact-of-psychological-treatments-for-people-with-epilepsy-on-health-related-quality-of-life
#13
REVIEW
Rosa Michaelis, Venus Tang, Janelle L Wagner, Avani C Modi, W Curt LaFrance, Laura H Goldstein, Tobias Lundgren, Markus Reuber
OBJECTIVE: Given the significant impact epilepsy can have on health-related quality of life (HRQoL) of individuals with this condition and their families, there is great clinical interest in evidence-based psychological treatments aimed at enhancing well-being in people with epilepsy (PWE). An evaluation of the current evidence is needed to assess the effects of psychological treatments for PWE on HRQoL outcomes to inform future therapeutic recommendations and research designs. METHODS: The operational definition of psychological treatments included a broad range of interventions that use psychological or behavioral techniques designed to improve HRQoL, psychiatric comorbidities, and seizure frequency and severity for adults and children with epilepsy...
January 3, 2018: Epilepsia
https://www.readbyqxmd.com/read/29310907/co-occurrence-and-severity-of-neurodevelopmental-burden-cognitive-impairment-cerebral-palsy-autism-spectrum-disorder-and-epilepsy-at-age-10-years-in-children-born-extremely-preterm
#14
Rachel G Hirschberger, Karl C K Kuban, Thomas M O'Shea, Robert M Joseph, Tim Heeren, Laurie Douglass, Carl E Stafstrom, Hernan Jara, Jean A Frazier, Deborah Hirtz, Julie Rollins, Nigel Paneth
BACKGROUND: This study aims to determine the prevalence of neurodevelopmental impairments at age ten years among children born extremely preterm (less than 28 weeks gestational age) and to offer a framework for categorizing neurological limitations. METHODS: A multicenter, prospective cohort follow-up study recruited 889 ten-year-old children born from 2002 to 2004. We assessed prevalence of cognitive impairment, measured by intelligent quotient and tests of executive function, cerebral palsy (CP), autism spectrum disorder (ASD), and epilepsy singly and in combination...
November 13, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29305781/health-related-quality-of-life-in-mothers-of-children-with-epilepsy-10%C3%A2-years-after-diagnosis
#15
Klajdi Puka, Mark A Ferro, Kelly K Anderson, Kathy N Speechley
PURPOSE: Epilepsy in childhood extends far beyond seizures and affects child and parental well-being. The long-term impact of childhood-onset epilepsy on parental well-being is unknown. This study assessed health-related quality of life (HRQOL) in mothers 10 years after their child's diagnosis of epilepsy. METHODS: Data come from the Health-Related Quality of Life in Children with Epilepsy Study, a multicenter prospective cohort study of children with newly diagnosed epilepsy...
January 5, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29305185/predictors-of-outcome-after-surgery-in-134-children-with-drug-resistant-tle
#16
Ashalatha Radhakrishnan, Ramshekhar Menon, Mathew Abraham, George Vilanilam, Suvasini Sharma, Bejoy Thomas, Chandrashekharan Kesavadas, Ajith Cherian, Raviprasad Varma, Sanjeev V Thomas
PURPOSE: To determine the factors predicting seizure outcome in children who underwent anterior temporal lobectomy (ATL) for drug-resistant temporal lobe epilepsy (TLE). METHODS: Among the 664 patients who underwent ATL for TLE from 1995 to 2008, there were 134 children. "Excellent" outcome in them was defined as seizure freedom during the entire follow-up (Engel class I a); "good outcome", if in remission last 2 years, and the rest as "unfavorable outcome". To identify the potential predictors of seizure recurrence, the attributes of recurred and non-recurred groups was compared by univariate and multivariate analysis...
January 2, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29303866/pet-and-ictal-spect-can-be-helpful-for-localizing-epileptic-foci
#17
Tim J von Oertzen
PURPOSE OF REVIEW: Functional neuroimaging with PET and SPECT is a commonly used tool in presurgical evaluation. The following article reviews the literature of PET and SPECT in presurgical assessment of epilepsies published in the last year. RECENT FINDINGS: FDG-PET adds concomitant information in temporal and extratemporal lobe epilepsy in adults and children. The pattern of hypometabolism in FDG-PET is a good additional predictor or seizure outcome in TLE with mesial temporal sclerosis or negative MRI...
January 4, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29301763/mental-disorder-in-children-with-physical-conditions-a-pilot-study
#18
Alexandra Butler, Ryan J Van Lieshout, Ellen Louise Lipman, Harriet L MacMillan, Andrea Gonzalez, Jan Willem Gorter, Kathy Georgiades, Kathy N Speechley, Michael H Boyle, Mark A Ferro
OBJECTIVES: Methodologically, to assess the feasibility of participant recruitment and retention, as well as missing data in studying mental disorder among children newly diagnosed with chronic physical conditions (ie, multimorbidity). Substantively, to examine the prevalence of multimorbidity, identify sociodemographic correlates and model the influence of multimorbidity on changes in child quality of life and parental psychosocial outcomes over a 6-month follow-up. DESIGN: Prospective pilot study...
January 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29296085/epilepsy-in-patients-with-autism-links-risks-and-treatment-challenges
#19
REVIEW
Frank Mc Besag
Autism is more common in people with epilepsy, approximately 20%, and epilepsy is more common in people with autism with reported rates of approximately 20%. However, these figures are likely to be affected by the current broader criteria for autism spectrum disorder (ASD), which have contributed to an increased prevalence of autism, with the result that the rate for ASD in epilepsy is likely to be higher and the figure for epilepsy in ASD is likely to be lower. Some evidence suggests that there are two peaks of epilepsy onset in autism, in infancy and adolescence...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29295802/hydrocephalus-in-pyridoxine-dependent-epilepsy-new-case-and-literature-review
#20
Virginia Navarro-Abia, María Soriano-Ramos, Noemí Núñez-Enamorado, Ana Camacho-Salas, Ana Martinez-de Aragón, Elena Martín-Hernández, Rogelio Simón-de Las Heras
INTRODUCTION: Pyridoxine-dependent epilepsy (PDE) is a rare disorder of the lysine metabolism, characterized by a pharmacoresistant epileptic encephalopathy that usually begins in the neonatal period. However, its phenotypic spectrum is wide and not limited to seizures. We report a new case of PDE who developed hydrocephalus, along with an exhaustive review of the literature. CASE REPORT: Our patient presented with seizures at 13 h of life. Antiepileptic drugs, vitamins and cofactors were required to achieve seizure control...
December 30, 2017: Brain & Development
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