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"Aging muscle"

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https://www.readbyqxmd.com/read/28314562/intermittent-vibration-protects-aged-muscle-from-mechanical-and-oxidative-damage-under-prolonged-compression
#1
Sing Wan Wong, Brian Chun Ho Cheung, Bruce Tak Keung Pang, Ateline Kwong, Anna Chung, Kenneth Ka Ho Lee, Arthur Fut Tak Mak
Deep tissue pressure ulcers, a serious clinical challenge originating in the muscle layer, are hardly detectable at the beginning. The challenge apparently occurs in aged subjects more frequently. As the ulcer propagates to the skin surface, it becomes very difficult to manage and can lead to fatal complications. Preventive measures are thus highly desirable. Although the complex pathological mechanisms have not been fully understood, prolonged and excessive physical challenges and oxidative stress are believed to be involved in the ulcer development...
February 27, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28286172/age-related-changes-in-skeletal-muscle-composition-a-pilot-nuclear-magnetic-resonance-spectroscopy-study-in-mice
#2
Anatoly P Sobolev, Luisa Mannina, Manuela Costanzo, Barbara Cisterna, Manuela Malatesta, Carlo Zancanaro
The composition of skeletal muscle was investigated in the quadriceps and gastrocnemius muscle of 13-month-old (n=15) and 23-month-old (n=19) mice by means of high-resolution nuclear magnetic resonance (NMR) spectroscopy. Muscle specimens were dissected out, frozen in liquid nitrogen and extracted in chloroform/methanol, and proton NMR spectra of the resulting aqueous and organic fractions were obtained at 600MHz. Several metabolites were unambiguously identified and quantified. Multivariate ANOVA (factor: age, muscle, age×muscle) showed a significant main effect of age (P=0...
March 7, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28265002/deletion-of-pofut1-in-mouse-skeletal-myofibers-induces-muscle-aging-related-phenotypes-in-cis-and-in-trans
#3
Deborah A Zygmunt, Neha Singhal, Mi-Lyang Kim, Megan L Cramer, Kelly E Crowe, Rui Xu, Ying Jia, Jessica Adair, Isabel Martinez-Pena Y Valenzuela, Mohammed Akaaboune, Peter White, Paulus M Janssen, Paul T Martin
Sarcopenia, the loss of muscle mass and strength during normal aging, involves coordinate changes in skeletal myofibers and the cells that contact them, including satellite cells and motor neurons. Here we show that Protein O-fucosyltransferase 1 (Pofut1), a gene that encodes a glycosyltransferase required for NotchR-mediated cell-cell signaling, has reduced expression in aging skeletal muscle. Moreover, premature postnatal deletion of Pofut1 in skeletal myofibers can induce aging-related phenotypes in cis within skeletal myofibers and in trans within satellite cells and within motor neurons via the neuromuscular junction...
March 6, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28258125/a-drosophila-model-of-dominant-inclusion-body-myopathy-3-shows-diminished-myosin-kinetics-that-reduce-muscle-power-and-yield-myofibrillar-defects
#4
Jennifer A Suggs, Girish C Melkani, Bernadette M Glasheen, Mia M Detor, Anju Melkani, Nathan P Marsan, Douglas M Swank, Sanford I Bernstein
Inclusion body myopathy type 3 (IBM-3) patients display congenital joint contractures with early-onset muscle weakness that becomes more severe in adults. The disease arises from an autosomal dominant point mutation causing an E706K substitution in myosin heavy chain type IIa. We previously expressed the corresponding myosin mutation (E701K) in homozygous Drosophila indirect flight muscles and recapitulated the myofibrillar degeneration and inclusion bodies observed in the human disease. We also found that purified E701K myosin has dramatically reduced actin-sliding velocity and ATPase levels...
March 3, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28181388/muscle-strength-mediates-the-relationship-between-mitochondrial-energetics-and-walking-performance
#5
Ariel C Zane, David A Reiter, Michelle Shardell, Donnie Cameron, Eleanor M Simonsick, Kenneth W Fishbein, Stephanie A Studenski, Richard G Spencer, Luigi Ferrucci
Skeletal muscle mitochondrial oxidative capacity declines with age and negatively affects walking performance, but the mechanism for this association is not fully clear. We tested the hypothesis that impaired oxidative capacity affects muscle performance and, through this mechanism, has a negative effect on walking speed. Muscle mitochondrial oxidative capacity was measured by in vivo phosphorus magnetic resonance spectroscopy as the postexercise phosphocreatine resynthesis rate, kPCr , in 326 participants (154 men), aged 24-97 years (mean 71), in the Baltimore Longitudinal Study of Aging...
February 9, 2017: Aging Cell
https://www.readbyqxmd.com/read/28143609/age-related-differences-in-muscle-co-activation-during-locomotion-and-their-relationship-with-gait-speed-a-pilot-study
#6
Hwang-Jae Lee, Won Hyuk Chang, Byung-Ok Choi, Gyu-Ha Ryu, Yun-Hee Kim
BACKGROUND: Muscle co-activation plays an important role in enhancing joint stability for movement regulation during motor learning activities. In normal aging, greater muscle co-activation is induced during gait in elderly adults. This study investigated age-related changes in muscle co-activation and spatio-temporal parameters during gait and identified the relationship between muscle co-activation and gait speed. METHODS: A total of 46 adult volunteers participated in this study in three age groups (15 young adults [8 males, 7 females; age, 24...
January 31, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28132725/sufficient-levels-of-25-hydroxyvitamin-d-and-protein-intake-required-to-increase-muscle-mass-in-sarcopenic-older-adults-the-provide-study
#7
Sjors Verlaan, Andrea B Maier, Jürgen M Bauer, Ivan Bautmans, Kirsten Brandt, Lorenzo M Donini, Marcello Maggio, Marion E T McMurdo, Tony Mets, Chris Seal, Sander L J Wijers, Cornel Sieber, Yves Boirie, Tommy Cederholm
BACKGROUND: Inadequate nutritional intake and altered response of aging muscles to anabolic stimuli from nutrients contribute to the development of sarcopenia. Nutritional interventions show inconsistent results in sarcopenic older adults, which might be influenced by their basal nutritional status. OBJECTIVE: To test if baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations and dietary protein intake influenced changes in muscle mass and function in older adults who received nutritional intervention...
January 17, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28078066/use-it-or-lose-it-tonic-activity-of-slow-motoneurons-promotes-their-survival-and-preferentially-increases-slow-fiber-type-groupings-in-muscles-of-old-lifelong-recreational-sportsmen
#8
Simone Mosole, Ugo Carraro, Helmut Kern, Stefan Loefler, Sandra Zampieri
Histochemistry, immuno-histochemistry, gel electrophoresis of single muscle fibers and electromyography of aging muscles and nerves suggest that: i) denervation contributes to muscle atrophy, ii) impaired mobility accelerates the process, and iii) lifelong running protects against loss of motor units. Recent corroborating results on the muscle effects of Functional Electrical Stimulation (FES) of aged muscles will be also mentioned, but we will in particular discuss how and why a lifelong increased physical activity sustains reinnervation of muscle fibers...
September 15, 2016: European Journal of Translational Myology
https://www.readbyqxmd.com/read/27934653/leucine-and-mammalian-target-of-rapamycin-dependent-activation-of-muscle-protein-synthesis-in-aging
#9
REVIEW
Jean-Pascal De Bandt
The preservation or restoration of muscle mass is of prime importance for healthy aging. However, aging has been repeatedly shown to be associated with resistance of muscle to the anabolic effects of feeding. Leucine supplementation has been proposed as a possible strategy because of its regulatory role on protein homeostasis. Indeed, it acts independently of growth factors and leads to enhanced cap-dependent mRNA translation initiation and increased protein synthesis. Leucine acts as a signaling molecule directly at the muscle level via the activation of mammalian/mechanistic target of rapamycin complex 1 (mTORC1)...
December 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27919074/epigenetic-stress-responses-induce-muscle-stem-cell-ageing-by-hoxa9-developmental-signals
#10
Simon Schwörer, Friedrich Becker, Christian Feller, Ali H Baig, Ute Köber, Henriette Henze, Johann M Kraus, Beibei Xin, André Lechel, Daniel B Lipka, Christy S Varghese, Manuel Schmidt, Remo Rohs, Ruedi Aebersold, Kay L Medina, Hans A Kestler, Francesco Neri, Julia von Maltzahn, Stefan Tümpel, K Lenhard Rudolph
The functionality of stem cells declines during ageing, and this decline contributes to ageing-associated impairments in tissue regeneration and function. Alterations in developmental pathways have been associated with declines in stem-cell function during ageing, but the nature of this process remains poorly understood. Hox genes are key regulators of stem cells and tissue patterning during embryogenesis with an unknown role in ageing. Here we show that the epigenetic stress response in muscle stem cells (also known as satellite cells) differs between aged and young mice...
December 15, 2016: Nature
https://www.readbyqxmd.com/read/27919069/stem-cells-cause-and-consequence-in-aged-muscle-decline
#11
Susan Eliazer, Andrew S Brack
No abstract text is available yet for this article.
December 15, 2016: Nature
https://www.readbyqxmd.com/read/27906106/loss-of-niche-satellite-cell-interactions-in-syndecan-3-null-mice-alters-muscle-progenitor-cell-homeostasis-improving-muscle-regeneration
#12
Addolorata Pisconti, Glen B Banks, Farshad Babaeijandaghi, Nicole Dalla Betta, Fabio M V Rossi, Jeffrey S Chamberlain, Bradley B Olwin
BACKGROUND: The skeletal muscle stem cell niche provides an environment that maintains quiescent satellite cells, required for skeletal muscle homeostasis and regeneration. Syndecan-3, a transmembrane proteoglycan expressed in satellite cells, supports communication with the niche, providing cell interactions and signals to maintain quiescent satellite cells. RESULTS: Syndecan-3 ablation unexpectedly improves regeneration in repeatedly injured muscle and in dystrophic mice, accompanied by the persistence of sublaminar and interstitial, proliferating myoblasts...
October 4, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27897419/exercise-restores-muscle-stem-cell-mobilization-regenerative-capacity-and-muscle-metabolic-alterations-via-adiponectin-adipor1-activation-in-samp10-mice
#13
Aiko Inoue, Xian Wu Cheng, Zhe Huang, Lina Hu, Ryosuke Kikuchi, Haiying Jiang, Limei Piao, Takeshi Sasaki, Kohji Itakura, Hongxian Wu, Guangxian Zhao, Yanna Lei, Guang Yang, Enbo Zhu, Xiang Li, Kohji Sato, Teruhiko Koike, Masafumi Kuzuya
BACKGROUND: Exercise train (ET) stimulates muscle response in pathological conditions, including aging. The molecular mechanisms by which exercise improves impaired adiponectin/adiponectin receptor 1 (AdipoR1)-related muscle actions associated with aging are poorly understood. Here we observed that in a senescence-accelerated mouse prone 10 (SAMP10) model, long-term ET modulated muscle-regenerative actions. METHODS: 25-week-old male SAMP10 mice were randomly assigned to the control and the ET (45 min/time, 3/week) groups for 4 months...
November 29, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27870893/activin-receptor-type-iib-inhibition-improves-muscle-phenotype-and-function-in-a-mouse-model-of-spinal-muscular-atrophy
#14
Min Liu, David W Hammers, Elisabeth R Barton, H Lee Sweeney
Spinal muscular atrophy (SMA) is a devastating neurodegenerative disorder that causes progressive muscle atrophy and weakness. Using adeno-associated virus-mediated gene transfer, we evaluated the potential to improve skeletal muscle weakness via systemic, postnatal inhibition of either myostatin or all signaling via the activin receptor type IIB (ActRIIB). After demonstrating elevated p-SMAD3 content and differential content of ActRIIB ligands, 4-week-old male C/C SMA model mice were treated intraperitoneally with 1x1012 genome copies of pseudotype 2/8 virus encoding a soluble form of the ActRIIB extracellular domain (sActRIIB) or protease-resistant myostatin propeptide (dnMstn) driven by a liver specific promoter...
2016: PloS One
https://www.readbyqxmd.com/read/27852976/age-associated-nf-%C3%AE%C2%BAb-signaling-in-myofibers-alters-the-satellite-cell-niche-and-re-strains-muscle-stem-cell-function
#15
Juhyun Oh, Indranil Sinha, Kah Yong Tan, Bernard Rosner, Jonathan M Dreyfuss, Ornela Gjata, Peter Tran, Steven E Shoelson, Amy J Wagers
Skeletal muscle is a highly regenerative tissue, but muscle repair potential is increasingly compromised with advancing age. In this study, we demonstrate that increased NF-κB activity in aged muscle fibers contributes to diminished myogenic potential of their associated satellite cells. We further examine the impact of genetic modulation of NF-κB signaling in muscle satellite cells or myofibers on recovery after damage. These studies reveal that NF-κB activity in differentiated myofibers is sufficient to drive dysfunction of muscle regenerative cells via cell-non-autonomous mechanisms...
November 14, 2016: Aging
https://www.readbyqxmd.com/read/27803160/extension-of-health-span-and-life-span-in-drosophila-by-s107-requires-the-calstabin-homologue-fk506-bp2
#16
Tabita Kreko-Pierce, Jorge Azpurua, Rebekah E Mahoney, Benjamin A Eaton
The accumulation of oxidative damage is strongly linked to age-dependent declines in cell function, but the contribution of oxidative damage to morbidity is still debated. Many organisms seem to tolerate oxidative damage, and the extension of health span and life span by augmenting antioxidant activity has been inconsistent. Here we use the Drosophila model system to investigate the relationship among oxidative stress, health span, and life span. The oxidation-dependent dissociation of the Calstabin protein from the ryanodine receptor has been shown to result in reduced muscle function in mammals...
December 9, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27760421/skeletal-muscle-regeneration-repair-and-remodelling-in-aging-the-importance-of-muscle-stem-cells-and-vascularization
#17
Sophie Joanisse, Joshua P Nederveen, Tim Snijders, Bryon R McKay, Gianni Parise
Sarcopenia is the age-related loss of skeletal muscle mass and strength. Ultimately, sarcopenia results in the loss of independence, which imposes a large financial burden on healthcare systems worldwide. A critical facet of sarcopenia is the diminished ability for aged muscle to regenerate, repair and remodel. Over the years, research has focused on elucidating underlying mechanisms of sarcopenia and the impaired ability of muscle to respond to stimuli with aging. Muscle-specific stem cells, termed satellite cells (SC), play an important role in maintaining muscle health throughout the lifespan...
2017: Gerontology
https://www.readbyqxmd.com/read/27757223/loss-of-niche-satellite-cell-interactions-in-syndecan-3-null-mice-alters-muscle-progenitor-cell-homeostasis-improving-muscle-regeneration
#18
Addolorata Pisconti, Glen B Banks, Farshad Babaeijandaghi, Nicole Dalla Betta, Fabio M V Rossi, Jeffrey S Chamberlain, Bradley B Olwin
BACKGROUND: The skeletal muscle stem cell niche provides an environment that maintains quiescent satellite cells, required for skeletal muscle homeostasis and regeneration. Syndecan-3, a transmembrane proteoglycan expressed in satellite cells, supports communication with the niche, providing cell interactions and signals to maintain quiescent satellite cells. RESULTS: Syndecan-3 ablation unexpectedly improves regeneration in repeatedly injured muscle and in dystrophic mice, accompanied by the persistence of sublaminar and interstitial, proliferating myoblasts...
2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27688482/impact-of-aging-on-proprioceptive-sensory-neurons-and-intrafusal-muscle-fibers-in-mice
#19
Sydney K Vaughan, Olivia L Stanley, Gregorio Valdez
The impact of aging on proprioceptive sensory neurons and intrafusal muscle fibers (IMFs) remains largely unexplored despite the central function these cells play in modulating voluntary movements. Here, we show that proprioceptive sensory neurons undergo deleterious morphological changes in middle age (11- to 13-month-old) and old (15- to 21-month-old) mice. In the extensor digitorum longus and soleus muscles of middle age and old mice, there is a significant increase in the number of Ia afferents with large swellings that fail to properly wrap around IMFs compared with young adult (2- to 4-month-old) mice...
September 29, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27687521/tongue-strength-is-associated-with-grip-strength-and-nutritional-status-in-older-adult-inpatients-of-a-rehabilitation-hospital
#20
Kotomi Sakai, Enri Nakayama, Haruka Tohara, Tomomi Maeda, Motonobu Sugimoto, Takahiro Takehisa, Yozo Takehisa, Koichiro Ueda
The aim of this cross-sectional study was to investigate whether tongue strength observed in older adult inpatients of a rehabilitation hospital is associated with muscle function, nutritional status, and dysphagia. A total of 174 older adult inpatients aged 65 years and older in rehabilitation (64 men, 110 women; median age, 84 years; interquartile range, 80-89 years) who were suspected of having reduced tongue strength due to sarcopenia were included in this study. Isometric tongue strength was measured using a device fitted with a disposable oral balloon probe...
September 29, 2016: Dysphagia
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