keyword
MENU ▼
Read by QxMD icon Read
search

"Aging muscle"

keyword
https://www.readbyqxmd.com/read/29782921/flight-duration-and-flight-muscle-ultrastructure-of-unfed-hawk-moths
#1
Bernard W M Wone, Jaika Pathak, Goggy Davidowitz
Flight muscle breakdown has been reported for many orders of insects, but the basis of this breakdown in insects with lifelong dependence on flight is less clear. Lepidopterans show such muscle changes across their lifespans, yet how this change affects the ability of these insects to complete their life cycles is not well documented. We investigated the changes in muscle function and ultrastructure of unfed aging adult hawk moths (Manduca sexta). Flight duration was examined in young, middle-aged, and advanced-aged unfed moths...
May 18, 2018: Arthropod Structure & Development
https://www.readbyqxmd.com/read/29781176/autophagy-and-mitophagy-flux-in-young-and-aged-skeletal-muscle-following-chronic-contractile-activity
#2
Heather N Carter, Yuho Kim, Avi T Erlich, Dorrin Zarrin-Khat, David A Hood
Skeletal muscle exhibits deficits in mitochondrial quality with age. Central to the maintenance of a healthy mitochondrial pool is the removal of dysfunctional organelles via mitophagy. Little is known on how mitophagy is altered with aging and chronic exercise. We assessed mitophagy flux using colchicine treatment in vivo following chronic contractile activity (CCA) of muscle in young and aged rats. CCA evoked mitochondrial biogenesis in young muscle, with an attenuated response in aged muscle. Mitophagy flux was higher in aged muscle and was correlated with the enhanced expression of mitophagy receptors and upstream transcriptional regulators...
May 20, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29751090/sex-dependent-and-sex-independent-muscle-activation-patterns-in-adult-gait-as-a-function-of-age
#3
Christopher A Bailey, Federica Corona, Giuseppina Pilloni, Micaela Porta, Maria Chiara Fastame, Paul Kenneth Hitchcott, Maria Pietronilla Penna, Massimiliano Pau, Julie N Côté
INTRODUCTION: Aging leads to poorer neuromuscular control that may impact mobility. However, the specific decades when these changes occur, and whether these time-based changes are sex-specific, are unclear. METHODS: Adults aged 20-82 years (N = 93, 51 females) walked six gait trials at their preferred speed over a 10-m platform. Electromyography (EMG) of the rectus femoris (RF), tibialis anterior (TA), and gastrocnemius lateralis (GL) were measured using wireless surface sensors...
May 8, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29726007/alterations-in-the-muscle-force-transfer-apparatus-in-aged-rats-during-unloading-and-reloading-impact-of-microrna-31
#4
David C Hughes, George R Marcotte, Leslie M Baehr, Daniel W D West, Andrea G Marshall, Scott M Ebert, Arik Davidyan, Christopher M Adams, Sue C Bodine, Keith Baar
KEY POINTS: Force transfer is integral for maintaining skeletal muscle structure and function. One important component is dystrophin. There is limited understanding of how force transfer is impacted by age and loading. Here, we investigate the force transfer apparatus in muscles of adult and old rats exposed to periods of disuse and reloading. Our results demonstrate an increase in dystrophin protein during the reloading phase in the adult TA muscle that is delayed in old. The consequence of this delay is an increased susceptibility towards contraction-induced muscle injury...
May 3, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29607567/shear-strain-rate-from-phase-contrast-velocity-encoded-mri-application-to-study-effects-of-aging-in-the-medial-gastrocnemius-muscle
#5
Usha Sinha, Vadim Malis, Robert Csapo, Marco Narici, Shantanu Sinha
BACKGROUND: Strain rate (SR) is a measure of the rate of regional deformation that can be computed by analyzing velocity-encoded phase-contrast 2D images. Recent studies have explored the changes in normal components of the strain tensor in aging muscle, while shear strain may also provide valuable information. PURPOSE: To compute the shear SR from velocity-encoded MRI of the lower leg and to study the correlation of SR parameters measured in the medial gastrocnemius (MG) to muscle force in a cohort of young and senior subjects...
April 1, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29593554/effects-of-resistance-training-on-matrix-metalloproteinase-activity-in-skeletal-muscles-and-blood-circulation-during-aging
#6
Ivo V de Sousa Neto, João L Q Durigan, Vinicius Guzzoni, Ramires A Tibana, Jonato Prestes, Heloisa S Selistre de Araujo, Rita de Cássia Marqueti
Aging is a complex, multifactorial process characterized by the accumulation of deleterious effects, including biochemical adaptations of the extracellular matrix (ECM). The purpose of this study was to investigate the effects of 12 weeks of resistance training (RT) on metalloproteinase 2 (MMP-2) activity in skeletal muscles and, MMP-2 and MMP-9 activity in the blood circulation of young and old rats. Twenty-eight Wistar rats were randomly divided into four groups ( n = 7 per group): young sedentary (YS); young trained (YT), old sedentary (OS), and old trained (OT)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29562317/impaired-mitochondrial-energetics-characterize-poor-early-recovery-of-muscle-mass-following-hind-limb-unloading-in-old-mice
#7
Xiaolei Zhang, Michelle B Trevino, Miao Wang, Stephen J Gardell, Julio E Ayala, Xianlin Han, Daniel P Kelly, Bret H Goodpaster, Rick B Vega, Paul M Coen
The progression of age-related sarcopenia can be accelerated by impaired recovery of muscle mass following periods of disuse due to illness or immobilization. However, the mechanisms underlying poor recovery of aged muscle following disuse remain to be delineated. Recent evidence suggests that mitochondrial energetics play an important role in regulation of muscle mass. Here, we report that 22-24 month old mice with low muscle mass and low glucose clearance rate also display poor early recovery of muscle mass following 10 days of hind limb unloading...
March 19, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29562315/the-protective-effect-of-melatonin-against-age-associated-sarcopenia-dependent-tubular-aggregates-formation-lactate-depletion-and-mitochondrial-changes
#8
Ramy K A Sayed, Marisol Fernández-Ortiz, María E Diaz-Casado, Iryna Rusanova, Ibtissem Rahim, Germaine Escames, Luis C López, Doaa M Mokhtar, Darío Acuña-Castroviejo
To gain insight into the mechanism of sarcopenia and the protective effect of melatonin, the gastrocnemius muscles of young (3-4 months), early-aged (12 months), and old-aged (24 months) wild type C57BL/6J female mice, were examined by magnetic resonance and microscopy. Locomotor activity, lactate production and nuclear apoptosis were also assessed. The results support the early onset of sarcopenia at 12 months of age, with reduction of muscle fibers' number, muscle weight/body weight ratio, lactate, and locomotor activity...
March 19, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29550562/muscle-fibers-and-their-synapses-differentially-adapt-to-aging-and-endurance-training
#9
Michael R Deschenes, Shuhan Li, Matthew A Adan, Jane J Oh, Hailey C Ramsey
BACKGROUND: This project aimed to determine the adaptability of the neuromuscular system to the stimuli of exercise training, and aging. METHODS: Young adult, and aged male rats were randomly assigned to either exercise training, or sedentary control groups. Exercise training featured an 8 week program of treadmill running. At the end of the intervention period, neuromuscular function was quantified with ex vivo stimulation procedures on isolated soleus muscles...
March 14, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29543139/effect-of-contractile-activity-on-pgc-1%C3%AE-transcription-in-young-and-aged-skeletal-muscle
#10
Heather N Carter, Marion Pauly, Liam D Tryon, David A Hood
Mitochondrial impairments are often noted in aged skeletal muscle. The transcriptional coactivator PGC-1α is integral to maintaining mitochondria, and its expression declines in aged muscle. It remains unknown whether this is due to a transcriptional deficit during aging. Our study examined PGC-1α transcription in muscle from young and old F344BN rats. Using a rat PGC-1α promoter-reporter construct, we found that PGC-1α transcription was reduced by ~65% in aged TA muscle, accompanied by decreases in PGC-1α mRNA and transcript stability...
March 15, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29532916/when-motor-unit-expansion-in-ageing-muscle-fails-atrophy-ensues
#11
Russell T Hepple
No abstract text is available yet for this article.
May 1, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29427317/overexpression-of-pgc-1%C3%AE-in-aging-muscle-enhances-a-subset-of-young-like-molecular-patterns
#12
Sofia Garcia, Nadee Nissanka, Edson A Mareco, Susana Rossi, Susana Peralta, Francisca Diaz, Richard L Rotundo, Robson F Carvalho, Carlos T Moraes
PGC-1α is a transcriptional co-activator known as the master regulator of mitochondrial biogenesis. Its control of metabolism has been suggested to exert critical influence in the aging process. We have aged mice overexpressing PGC-1α in skeletal muscle to determine whether the transcriptional changes reflected a pattern of expression observed in younger muscle. Analyses of muscle proteins showed that Pax7 and several autophagy markers were increased. In general, the steady-state levels of several muscle proteins resembled that of muscle from young mice...
April 2018: Aging Cell
https://www.readbyqxmd.com/read/29401629/resistance-training-prevents-muscle-fibrosis-and-atrophy-via-down-regulation-of-c1q-induced-wnt-signaling-in-senescent-mice
#13
Naoki Horii, Masataka Uchida, Natsuki Hasegawa, Shumpei Fujie, Eri Oyanagi, Hiromi Yano, Takeshi Hashimoto, Motoyuki Iemitsu
Increased complement component 1q (C1q) secretion with aging leads to muscle fibrosis and atrophy whereas resistance training attenuates circulating C1q levels. This study aimed to clarify whether resistance exercise-induced reduction of C1q secretion contributes to the inhibition of fibrosis and atrophy in aged muscles. Young (13-wk-old) and aged (38-wk-old) senescence-accelerated mouse prone 1 mice were randomly assigned to one of 4 groups: a young or aged sedentary control group, or a young or aged resistance training (climbing a ladder 3 d/wk for 12 wk) group...
January 30, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29389741/defining-anabolic-resistance-implications-for-delivery-of-clinical-care-nutrition
#14
Robert W Morton, Daniel A Traylor, Peter J M Weijs, Stuart M Phillips
PURPOSE OF REVIEW: Skeletal muscle mass with aging, during critical care, and following critical care is a determinant of quality of life and survival. In this review, we discuss the mechanisms that underpin skeletal muscle atrophy and recommendations to offset skeletal muscle atrophy with aging and during, as well as following, critical care. RECENT FINDINGS: Anabolic resistance is responsible, in part, for skeletal muscle atrophy with aging, muscle disuse, and during disease states...
April 2018: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29368427/physical-activity-unveils-the-relationship-between-mitochondrial-energetics-muscle-quality-and-physical-function-in-older-adults
#15
Giovanna Distefano, Robert A Standley, Xiaolei Zhang, Elvis A Carnero, Fanchao Yi, Heather H Cornnell, Paul M Coen
BACKGROUND: The concept of mitochondrial dysfunction in ageing muscle is highly controversial. In addition, emerging evidence suggests that reduced muscle oxidative capacity and efficiency underlie the aetiology of mobility loss in older adults. Here, we hypothesized that studying well-phenotyped older cohorts across a wide range of physical activity would unveil a range of mitochondrial function in skeletal muscle and in turn allow us to more clearly examine the impact of age per se on mitochondrial energetics...
January 24, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29357501/effects-of-aging-and-parkinson-s-disease-on-motor-unit-remodeling-influence-of-resistance-exercise-training
#16
Neil A Kelly, Kelley G Hammond, C Scott Bickel, Samuel T Windham, S Craig Tuggle, Marcas M Bamman
Aging muscle atrophy is in part a neurodegenerative process revealed by denervation/reinnervation events leading to motor unit remodeling (i.e., myofiber type grouping). However, this process and its physiological relevance are poorly understood, as is the wide-ranging heterogeneity among aging humans. Here, we attempted to address 1) the relation between myofiber type grouping and molecular regulators of neuromuscular junction (NMJ) stability; 2) the impact of motor unit remodeling on recruitment during submaximal contractions; 3) the prevalence and impact of motor unit remodeling in Parkinson's disease (PD), an age-related neurodegenerative disease; and 4) the influence of resistance exercise training (RT) on regulators of motor unit remodeling...
April 1, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29343811/a-procession-of-metabolic-alterations-accompanying-muscle-senescence-in-manduca-sexta
#17
Bernard W M Wone, Jason M Kinchen, Elana R Kaup, Beate Wone
Biological aging profoundly impairs muscle function, performance, and metabolism. Because the progression of metabolic alterations associated with aging muscle has not been chronicled, we tracked the metabolic profiles of flight muscle from middle to advanced age in Manduca sexta to identify key molecules during the progression of muscle aging, as well as to evaluate the utility of the M. sexta system for molecular dissection of muscle aging. We identified a number of differences between Diel Time, Sexes, and Muscle Ages, including changes in metabolites related to energetics, extracellular matrix turnover, and glutathione metabolism...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29305003/muscle-stem-cells-and-aging
#18
Ara B Hwang, Andrew S Brack
Satellite cells (SCs) are a population of muscle-resident stem cells that are essential for efficient tissue repair. SCs reside in a relatively quiescent state during normal tissue turnover, but are activated in response to injury through the microenvironment and cell-intrinsic signals. During aging, SC dysfunction is a major contributor to the decline in regenerative potential of muscle tissue. Recent studies have demonstrated that both cell-intrinsic and cell-extrinsic factors are deregulated during aging...
2018: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/29299226/mobility-disorders-and-pain-interrelations-that-need-new-research-concepts-and-advanced-clinical-commitments
#19
Sascha Sajer
This Perspective will discuss topics recently suggested by Prof. Helmut Kern, Vienna, Austria, to advance the research activities of his team, that is: Topic A, 10 years post RISE; Topic B, New research for new solutions on old research questions; Topic C, Working groups on nerve regeneration, training-parameters of seniors in different ages, muscle adaptation; and studies of connective tissue and cartilage. This Perspective summarizes some of the basic concepts and of the evidence-based tools for developing further translational research activities...
December 5, 2017: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29278025/the-influence-of-aging-on-the-effectiveness-of-heat-stress-in-preventing-disuse-muscle-atrophy
#20
H Kataoka, J Nakano, Y Kondo, Y Honda, J Sakamoto, T Origuchi, M Okita
This study examined the aging effect on disuse muscle atrophy prevention using heat stress. Wistar rats aged 7 and 60 weeks were divided into three groups as follows: control, immobilized (Im), and immobilized and heat stressed (ImH). Heat stress was given by immersing the hindlimbs in hot water (42 °C) for 60 min, once in every 3 days and the gastrocnemius (GAS) and soleus (SOL) muscles were extracted after 14 days. Muscle-fiber types were classified using ATPase staining. Heat shock protein 70 (HSP70) was assessed through Western blotting...
December 1, 2017: Physiology International
keyword
keyword
116599
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"