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"Aging muscle"

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https://www.readbyqxmd.com/read/29114203/collagen-vi-null-mice-as-a-model-for-early-onset-muscle-decline-in-aging
#1
Daniele Capitanio, Manuela Moriggi, Sara De Palma, Dario Bizzotto, Sibilla Molon, Enrica Torretta, Chiara Fania, Paolo Bonaldo, Cecilia Gelfi, Paola Braghetta
Collagen VI is an extracellular matrix (ECM) protein playing a key role in skeletal muscles and whose deficiency leads to connective tissue diseases in humans and in animal models. However, most studies have been focused on skeletal muscle features. We performed an extensive proteomic profiling in two skeletal muscles (diaphragm and gastrocnemius) of wild-type and collagen VI null (Col6a1(-/-)) mice at different ages, from 6- (adult) to 12- (aged) month-old to 24 (old) month-old. While in wild-type animals the number of proteins and the level of modification occurring during aging were comparable in the two analyzed muscles, Col6a1(-/-) mice displayed a number of muscle-type specific variations...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29102726/differential-gene-expression-analysis-in-ageing-muscle-and-drug-discovery-perspectives
#2
REVIEW
Aicha Melouane, Abdelaziz Ghanemi, Simon Aubé, Mayumi Yoshioka, Jonny St-Amand
Identifying therapeutic target genes represents the key step in functional genomics-based therapies. Within this context, the disease heterogeneity, the exogenous factors and the complexity of genomic structure and function represent important challenges. The functional genomics aims to overcome such obstacles via identifying the gene functions and therefore highlight disease-causing genes as therapeutic targets. Genomic technologies promise to reshape the research on ageing muscle, exercise response and drug discovery...
November 1, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/29094772/mechanosensitiviy-of-aged-muscle-stem-cells
#3
Heleen E Boers, Mohammad Haroon, Fabien Le Grand, Astrid D Bakker, Jenneke Klein-Nulend, Richard T Jaspers
During aging, skeletal muscle tissue progressively declines in mass, strength, and regenerative capacity. Decreased muscle stem cell (MuSC) number and impaired function might underlie the aging-related muscle wasting and impaired regenerative capacity. As yet, the search for factors that regulate MuSC fate and function has revealed several biochemical factors within the MuSC niche that may be responsible for the decline in MuSC regenerative capacity. This decline cannot be explained by environmental factors solely, as the MuSC potential to regenerate muscle tissue is not reversed by changing the biochemical MuSC niche composition...
November 2, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29058056/gut-microbiota-contribute-to-age-related-changes-in-skeletal-muscle-size-composition-and-function-biological-basis-for-a-gut-muscle-axis
#4
REVIEW
Gregory J Grosicki, Roger A Fielding, Michael S Lustgarten
Skeletal muscle is a highly plastic tissue that plays a central role in human health and disease. Aging is associated with a decrease in muscle mass and function (sarcopenia) that is associated with a loss of independence and reduced quality of life. Gut microbiota, the bacteria, archaea, viruses, and eukaryotic microbes residing in the gastrointestinal tract are emerging as a potential contributor to age-associated muscle decline. Specifically, advancing age is characterized by a dysbiosis of gut microbiota that is associated with increased intestinal permeability, facilitating the passage of endotoxin and other microbial products (e...
October 20, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29056555/the-effect-of-arc-ablation-on-skeletal-muscle-morphology-function-and-apoptotic-signaling-during-aging
#5
Kira Vorobej, Andrew S Mitchell, Ian C Smith, Stefan Donath, A Russell Tupling, Joe Quadrilatero
Augmented apoptotic signaling can result in degradation of skeletal muscle proteins and loss of myonuclei, ultimately contributing to muscle atrophy and contractile dysfunction. Apoptosis repressor with caspase recruitment domain (ARC) is an anti-apoptotic protein highly expressed in skeletal muscle. Here we examined the role of ARC on age-related skeletal muscle apoptosis and wasting by utilizing an ARC-deficient mouse model. Aged mice displayed a number of morphological, phenotypic, and contractile alterations in both soleus and plantaris muscle with aging...
October 19, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28980384/noncompaction-cardiomyopathy-in-an-infant-with-walker-warburg-syndrome
#6
Sarah Abdullah, Cynthia Hawkins, Gregory Wilson, Grace Yoon, Luc Mertens, Melissa T Carter, Andrea Guerin
Walker-Warburg syndrome (WWS) is a rare autosomal recessive, congenital muscular dystrophy that is associated with brain and eye anomalies. Several genes encoding proteins involved in α-dystroglycan glycosylation have been implicated in the aetiology of WWS. We describe a patient with nonclassical features of WWS presenting with heart failure related to noncompaction cardiomyopathy resulting in death at 4 months of age. Muscle biopsy revealed absent α-dystroglycan on immunostaining and genetic testing confirmed the diagnosis with two previously described POMT2 mutations...
October 5, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28964826/randomized-four-arm-dose-response-clinical-trial-to-optimize-resistance-exercise-training-for-older-adults-with-age-related-muscle-atrophy
#7
Michael J Stec, Anna Thalacker-Mercer, David L Mayhew, Neil A Kelly, S Craig Tuggle, Edward K Merritt, Cynthia J Brown, Samuel T Windham, Louis J Dell'Italia, C Scott Bickel, Brandon M Roberts, Kristina M Vaughn, Irina Isakova-Donahue, Gina M Many, Marcas M Bamman
PURPOSE: The myriad consequences of age-related muscle atrophy include reduced muscular strength, power, and mobility; increased risk of falls, disability, and metabolic disease; and compromised immune function. At its root, aging muscle atrophy results from a loss of myofibers and atrophy of the remaining type II myofibers. The purpose of this trial (NCT02442479) was to titrate the dose of resistance training (RT) in older adults in an effort to maximize muscle regrowth and gains in muscle function...
December 1, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28958717/musculoskeletal-deformities-following-neonatal-thoracotomy-long-term-follow-up-of-an-esophageal-atresia-cohort
#8
Sunny Wei, Neil Saran, Sherif Emil
BACKGROUND: Musculoskeletal deformities (MD), including scoliosis and chest wall anomalies, are potential long-term complications of neonatal thoracotomies. METHODS: We studied the incidence of MD in patients who underwent open repair of esophageal atresia between 1997 and 2012, had no other predisposition to MD, and subsequently received longitudinal follow-up in a multidisciplinary esophageal atresia clinic. Detailed chest wall and musculoskeletal exams were performed at each visit...
September 5, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28869535/mitochondrial-targeted-antioxidant-maintains-blood-flow-mitochondrial-function-and-redox-balance-in-old-mice-following-prolonged-limb-ischemia
#9
Shunsuke Miura, Shu-Ichi Saitoh, Tomoki Kokubun, Takashi Owada, Hiroyuki Yamauchi, Hirofumi Machii, Yasuchika Takeishi
Aging is a major factor in the decline of limb blood flow with ischemia. However, the underlying mechanism remains unclear. We investigated the role of mitochondrial reactive oxygen species (ROS) with regard to limb perfusion recovery in aging during ischemia. We performed femoral artery ligation in young and old mice with or without treatment with a scavenger of mitochondrial superoxide, MitoTEMPO (180 μg/kg/day, from pre-operative day 7 to post-operative day (POD) 21) infusion using an implanted mini-pump...
September 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28817355/total-training-load-may-explain-similar-strength-gains-and-muscle-hypertrophy-seen-in-aged-rats-submitted-to-resistance-training-and-anabolic-steroids
#10
Walter Krause Neto, Wellington de Assis Silva, Adriano Polican Ciena, Danilo Bocalini, Ricardo Aparecido Baptista Nucci, Carlos Alberto Anaruma, Eliane Florencio Gama
This study aimed to quantify training parameters and analyze the morphological response of aged muscles submitted to resistance training and anabolic steroids. Aged Wistar rats were divided into groups: C - initial control; CF - final control; CAS - control with anabolic steroid, RT - resistance training, and RTA - resistance training with anabolic steroid. Maximum carried load, absolute and relative loads increased significantly in RT and RTA. RTA demonstrated greater relative load than RT. Average total volume, total climbing volume, relative total volume, relative total climbing volume, and mean climbing volume were similar between groups RT and RTA...
August 17, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28751202/r1%C3%AF-dispersion-and-sodium-imaging-in-human-calf-muscle
#11
Ping Wang, He Zhu, Hakmook Kang, John C Gore
PURPOSE: To evaluate the magnitude of chemical exchange effects and R1ρ dispersion in muscle and their relationship to tissue sodium levels with aging. METHODS: Seven healthy volunteers (aged 24 to 87years, median age 47) underwent MRI to assess tissue sodium levels and water T1ρ values at different spin-locking frequencies in calf muscles. T1ρ values at each locking field were computed based on a three-parameter mono-exponential model to fit signals obtained at different locking times, and R1ρ (=1/T1ρ) rates were compared at different locking fields...
July 24, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28704219/inflammaging-and-the-age-specific-responsiveness-to-stretch-shortening-contractions
#12
Erik P Rader, Brent A Baker
With aging, muscle injury from rapid, continuous stretch-shortening contractions (SSC) is prolonged, and maladaptation to moderate-velocity, intermittent SSC is more common. We hypothesize that high baseline levels of inflammatory signaling and oxidative stress may underlie these outcomes, whereas careful modulation of high-intensity SSC training design resets basal conditions and permits muscle adaptation to SSC.
October 2017: Exercise and Sport Sciences Reviews
https://www.readbyqxmd.com/read/28668235/severe-hypotonia-and-postnatal-growth-impairment-in-a-girl-with-a-missense-mutation-in-col1a1-implication-of-expanded-phenotypic-spectrum-of-type-i-collagenopathy
#13
Jin Sook Lee, Jieun Seo, Anna Cho, Byung Chan Lim, Murim Choi, Jung-Wook Kim, Ok-Hwa Kim, Tae-Joon Cho, Jong-Hee Chae
BACKGROUND: It is known that type I collagenopathy has a broad-spectrum phenotypic variability. Here, we report a case of a Korean girl with a heterozygous COL1A1 mutation who had an atypical presentation. CASE PRESENTATION: A 26-month-old girl presented with delayed motor development and failure to thrive. She had severe growth retardation. She exhibited right-sided plagiocephaly, blue sclerae, and facial dysmorphism, including a small pointed chin, frontal bossing, and a triangular face, but had microcephaly...
June 28, 2017: Brain & Development
https://www.readbyqxmd.com/read/28656072/impact-of-aging-and-exercise-on-mitochondrial-quality-control-in-skeletal-muscle
#14
REVIEW
Yuho Kim, Matthew Triolo, David A Hood
Mitochondria are characterized by its pivotal roles in managing energy production, reactive oxygen species, and calcium, whose aging-related structural and functional deteriorations are observed in aging muscle. Although it is still unclear how aging alters mitochondrial quality and quantity in skeletal muscle, dysregulation of mitochondrial biogenesis and dynamic controls has been suggested as key players for that. In this paper, we summarize current understandings on how aging regulates muscle mitochondrial biogenesis, while focusing on transcriptional regulations including PGC-1α, AMPK, p53, mtDNA, and Tfam...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28649424/an-alanine-expanded-pabpn1-causes-increased-utilization-of-intronic-polyadenylation-sites
#15
Tooba Abbassi-Daloii, Soheil Yousefi, Eleonora de Klerk, Laurens Grossouw, Muhammad Riaz, Peter A C 't Hoen, Vered Raz
In eukaryote genomes, the polyadenylation site marks termination of mature RNA transcripts by a poly-adenine tail. The polyadenylation site is recognized by a dynamic protein complex, among which the poly-adenine-binding protein nuclear1 plays a key role. Reduced poly-adenine-binding protein nuclear1 levels are found in aged muscles and are even lower in oculopharyngeal muscular dystrophy patients. Oculopharyngeal muscular dystrophy is a rare, late onset autosomal dominant myopathy, and is caused by an alanine expansion mutation in poly-adenine-binding protein nuclear1...
2017: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/28596299/postexercise-essential-amino-acid-supplementation-amplifies-skeletal-muscle-satellite-cell-proliferation-in-older-men-24%C3%A2-hours-postexercise
#16
Paul T Reidy, Christopher S Fry, Jared M Dickinson, Micah J Drummond, Blake B Rasmussen
Aged skeletal muscle has an attenuated and delayed ability to proliferate satellite cells in response to resistance exercise. The mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway is a focal point for cell growth, however, the effect of postexercise mTORC1 activation on human skeletal muscle satellite cell (SC) proliferation is unknown. To test the proliferative capacity of skeletal muscle SC in aging muscle to a potent mTORC1 activator (i.e., EAA; essential amino acids) we recruited older (~72y) men to conduct leg resistance exercise (8setsx10reps) without (-EAA; n = 8) and with (+EAA: n = 11) ingestion of 10 g of EAA 1 h postexercise...
June 2017: Physiological Reports
https://www.readbyqxmd.com/read/28583253/loss-of-adult-skeletal-muscle-stem-cells-drives-age-related-neuromuscular-junction-degeneration
#17
Wenxuan Liu, Alanna Klose, Sophie Forman, Nicole D Paris, Lan Wei-LaPierre, Mariela Cortés-Lopéz, Aidi Tan, Morgan Flaherty, Pedro Miura, Robert T Dirksen, Joe V Chakkalakal
Neuromuscular junction degeneration is a prominent aspect of sarcopenia, the age-associated loss of skeletal muscle integrity. Previously, we showed that muscle stem cells activate and contribute to mouse neuromuscular junction regeneration in response to denervation (Liu et al., 2015). Here, we examined gene expression profiles and neuromuscular junction integrity in aged mouse muscles, and unexpectedly found limited denervation despite a high level of degenerated neuromuscular junctions. Instead, degenerated neuromuscular junctions were associated with reduced contribution from muscle stem cells...
June 6, 2017: ELife
https://www.readbyqxmd.com/read/28462114/age-related-functional-changes-and-susceptibility-to-eccentric-contraction-induced-damage-in-skeletal-muscle-cell
#18
REVIEW
Seung-Jun Choi
Depending upon external loading conditions, skeletal muscles can either shorten, lengthen, or remain at a fixed length as they produce force. Fixed-end or isometric contractions stabilize joints and allow muscles to act as active struts during locomotion. Active muscles dissipate energy when they are lengthened by an external force that exceeds their current force producing capacity. These unaccustomed eccentric activities often lead to muscle weakness, soreness, and inflammation. During aging, the ability to produce force under these conditions is reduced and appears to be due to not only reductions in muscle mass but also to alterations in the basic mechanisms of contraction...
September 2016: Integrative medicine research
https://www.readbyqxmd.com/read/28448086/effects-of-running-wheel-activity-and-dietary-hmb-and-%C3%AE-alanine-co-supplementation-on-muscle-quality-in-aged-male-rats
#19
D W Russ, C Acksel, K W McCorkle, N K Edens, S M Garvey
OBJECTIVE: Loss of skeletal muscle function is linked to increased risk for loss of health and independence in older adults. Dietary interventions that can enhance aging muscle function, alone or in combination with exercise, may offer an effective way to reduce these risks. The goal of this study was to evaluate the muscular effects of beta-hydroxy-beta-methylbutyrate (HMB) and beta-alanine (β-Ala) co-supplementation in aged Sprague-Dawley rats with voluntary access to running wheels (RW)...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28446595/dna-damage-signaling-mediates-the-functional-antagonism-between-replicative-senescence-and-terminal-muscle-differentiation
#20
Lucia Latella, Alessandra Dall'Agnese, Francesca Boscolo Sesillo, Chiara Nardoni, Marianna Cosentino, Armin Lahm, Alessandra Sacco, Pier Lorenzo Puri
The molecular determinants of muscle progenitor impairment to regenerate aged muscles are currently unclear. We show that, in a mouse model of replicative senescence, decline in muscle satellite cell-mediated regeneration coincides with activation of DNA damage response (DDR) and impaired ability to differentiate into myotubes. Inhibition of DDR restored satellite cell differentiation ability. Moreover, in replicative human senescent fibroblasts, DDR precluded MYOD-mediated activation of the myogenic program...
April 1, 2017: Genes & Development
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