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https://www.readbyqxmd.com/read/27919074/epigenetic-stress-responses-induce-muscle-stem-cell-ageing-by-hoxa9-developmental-signals
#1
Simon Schwörer, Friedrich Becker, Christian Feller, Ali H Baig, Ute Köber, Henriette Henze, Johann M Kraus, Beibei Xin, André Lechel, Daniel B Lipka, Christy S Varghese, Manuel Schmidt, Remo Rohs, Ruedi Aebersold, Kay L Medina, Hans A Kestler, Francesco Neri, Julia von Maltzahn, Stefan Tümpel, K Lenhard Rudolph
The functionality of stem cells declines during ageing, and this decline contributes to ageing-associated impairments in tissue regeneration and function. Alterations in developmental pathways have been associated with declines in stem-cell function during ageing, but the nature of this process remains poorly understood. Hox genes are key regulators of stem cells and tissue patterning during embryogenesis with an unknown role in ageing. Here we show that the epigenetic stress response in muscle stem cells (also known as satellite cells) differs between aged and young mice...
November 30, 2016: Nature
https://www.readbyqxmd.com/read/27919069/stem-cells-cause-and-consequence-in-aged-muscle-decline
#2
Susan Eliazer, Andrew S Brack
No abstract text is available yet for this article.
November 30, 2016: Nature
https://www.readbyqxmd.com/read/27906106/loss-of-niche-satellite-cell-interactions-in-syndecan-3-null-mice-alters-muscle-progenitor-cell-homeostasis-improving-muscle-regeneration
#3
Addolorata Pisconti, Glen B Banks, Farshad Babaeijandaghi, Nicole Dalla Betta, Fabio M V Rossi, Jeffrey S Chamberlain, Bradley B Olwin
BACKGROUND: The skeletal muscle stem cell niche provides an environment that maintains quiescent satellite cells, required for skeletal muscle homeostasis and regeneration. Syndecan-3, a transmembrane proteoglycan expressed in satellite cells, supports communication with the niche, providing cell interactions and signals to maintain quiescent satellite cells. RESULTS: Syndecan-3 ablation unexpectedly improves regeneration in repeatedly injured muscle and in dystrophic mice, accompanied by the persistence of sublaminar and interstitial, proliferating myoblasts...
October 4, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27897419/exercise-restores-muscle-stem-cell-mobilization-regenerative-capacity-and-muscle-metabolic-alterations-via-adiponectin-adipor1-activation-in-samp10-mice
#4
Aiko Inoue, Xian Wu Cheng, Zhe Huang, Lina Hu, Ryosuke Kikuchi, Haiying Jiang, Limei Piao, Takeshi Sasaki, Kohji Itakura, Hongxian Wu, Guangxian Zhao, Yanna Lei, Guang Yang, Enbo Zhu, Xiang Li, Kohji Sato, Teruhiko Koike, Masafumi Kuzuya
BACKGROUND: Exercise train (ET) stimulates muscle response in pathological conditions, including aging. The molecular mechanisms by which exercise improves impaired adiponectin/adiponectin receptor 1 (AdipoR1)-related muscle actions associated with aging are poorly understood. Here we observed that in a senescence-accelerated mouse prone 10 (SAMP10) model, long-term ET modulated muscle-regenerative actions. METHODS: 25-week-old male SAMP10 mice were randomly assigned to the control and the ET (45 min/time, 3/week) groups for 4 months...
November 29, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27870893/activin-receptor-type-iib-inhibition-improves-muscle-phenotype-and-function-in-a-mouse-model-of-spinal-muscular-atrophy
#5
Min Liu, David W Hammers, Elisabeth R Barton, H Lee Sweeney
Spinal muscular atrophy (SMA) is a devastating neurodegenerative disorder that causes progressive muscle atrophy and weakness. Using adeno-associated virus-mediated gene transfer, we evaluated the potential to improve skeletal muscle weakness via systemic, postnatal inhibition of either myostatin or all signaling via the activin receptor type IIB (ActRIIB). After demonstrating elevated p-SMAD3 content and differential content of ActRIIB ligands, 4-week-old male C/C SMA model mice were treated intraperitoneally with 1x1012 genome copies of pseudotype 2/8 virus encoding a soluble form of the ActRIIB extracellular domain (sActRIIB) or protease-resistant myostatin propeptide (dnMstn) driven by a liver specific promoter...
2016: PloS One
https://www.readbyqxmd.com/read/27852976/age-associated-nf-%C3%AE%C2%BAb-signaling-in-myofibers-alters-the-satellite-cell-niche-and-re-strains-muscle-stem-cell-function
#6
Juhyun Oh, Indranil Sinha, Kah Yong Tan, Bernard Rosner, Jonathan M Dreyfuss, Ornela Gjata, Peter Tran, Steven E Shoelson, Amy J Wagers
Skeletal muscle is a highly regenerative tissue, but muscle repair potential is increasingly compromised with advancing age. In this study, we demonstrate that increased NF-κB activity in aged muscle fibers contributes to diminished myogenic potential of their associated satellite cells. We further examine the impact of genetic modulation of NF-κB signaling in muscle satellite cells or myofibers on recovery after damage. These studies reveal that NF-κB activity in differentiated myofibers is sufficient to drive dysfunction of muscle regenerative cells via cell-non-autonomous mechanisms...
November 14, 2016: Aging
https://www.readbyqxmd.com/read/27803160/extension-of-health-span-and-life-span-in-drosophila-by-s107-requires-the-calstabin-homologue-fk506-bp2
#7
Tabita Kreko-Pierce, Jorge Azpurua, Rebekah E Mahoney, Benjamin A Eaton
The accumulation of oxidative damage is strongly linked to age-dependent declines in cell function but the contribution of oxidative damage to morbidity is still debated. Many organisms seem to tolerate oxidative damage, and the extension of health span and lifespan by augmenting antioxidant activity has been inconsistent. Here we use the Drosophila model system to investigate the relationship among oxidative stress, health span, and lifespan. The oxidation-dependent dissociation of the Calstabin protein from the ryanodine receptor has been shown to result in reduced muscle function in mammals...
November 1, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27760421/skeletal-muscle-regeneration-repair-and-remodelling-in-aging-the-importance-of-muscle-stem-cells-and-vascularization
#8
Sophie Joanisse, Joshua P Nederveen, Tim Snijders, Bryon R McKay, Gianni Parise
Sarcopenia is the age-related loss of skeletal muscle mass and strength. Ultimately, sarcopenia results in the loss of independence, which imposes a large financial burden on healthcare systems worldwide. A critical facet of sarcopenia is the diminished ability for aged muscle to regenerate, repair and remodel. Over the years, research has focused on elucidating underlying mechanisms of sarcopenia and the impaired ability of muscle to respond to stimuli with aging. Muscle-specific stem cells, termed satellite cells (SC), play an important role in maintaining muscle health throughout the lifespan...
October 20, 2016: Gerontology
https://www.readbyqxmd.com/read/27757223/loss-of-niche-satellite-cell-interactions-in-syndecan-3-null-mice-alters-muscle-progenitor-cell-homeostasis-improving-muscle-regeneration
#9
Addolorata Pisconti, Glen B Banks, Farshad Babaeijandaghi, Nicole Dalla Betta, Fabio M V Rossi, Jeffrey S Chamberlain, Bradley B Olwin
BACKGROUND: The skeletal muscle stem cell niche provides an environment that maintains quiescent satellite cells, required for skeletal muscle homeostasis and regeneration. Syndecan-3, a transmembrane proteoglycan expressed in satellite cells, supports communication with the niche, providing cell interactions and signals to maintain quiescent satellite cells. RESULTS: Syndecan-3 ablation unexpectedly improves regeneration in repeatedly injured muscle and in dystrophic mice, accompanied by the persistence of sublaminar and interstitial, proliferating myoblasts...
2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27688482/impact-of-aging-on-proprioceptive-sensory-neurons-and-intrafusal-muscle-fibers-in-mice
#10
Sydney K Vaughan, Olivia L Stanley, Gregorio Valdez
The impact of aging on proprioceptive sensory neurons and intrafusal muscle fibers (IMFs) remains largely unexplored despite the central function these cells play in modulating voluntary movements. Here, we show that proprioceptive sensory neurons undergo deleterious morphological changes in middle age (11- to 13-month-old) and old (15- to 21-month-old) mice. In the extensor digitorum longus and soleus muscles of middle age and old mice, there is a significant increase in the number of Ia afferents with large swellings that fail to properly wrap around IMFs compared with young adult (2- to 4-month-old) mice...
September 29, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27687521/tongue-strength-is-associated-with-grip-strength-and-nutritional-status-in-older-adult-inpatients-of-a-rehabilitation-hospital
#11
Kotomi Sakai, Enri Nakayama, Haruka Tohara, Tomomi Maeda, Motonobu Sugimoto, Takahiro Takehisa, Yozo Takehisa, Koichiro Ueda
The aim of this cross-sectional study was to investigate whether tongue strength observed in older adult inpatients of a rehabilitation hospital is associated with muscle function, nutritional status, and dysphagia. A total of 174 older adult inpatients aged 65 years and older in rehabilitation (64 men, 110 women; median age, 84 years; interquartile range, 80-89 years) who were suspected of having reduced tongue strength due to sarcopenia were included in this study. Isometric tongue strength was measured using a device fitted with a disposable oral balloon probe...
September 29, 2016: Dysphagia
https://www.readbyqxmd.com/read/27679740/increased-taurine-in-pre-weaned-juvenile-mdx-mice-greatly-reduces-the-acute-onset-of-myofibre-necrosis-and-dystropathology-and-prevents-inflammation
#12
Jessica R Terrill, Miranda D Grounds, Peter G Arthur
BACKGROUND: The mdx mouse model for the fatal muscle wasting disease Duchenne Muscular Dystrophy (DMD) shows a very mild pathology once growth has ceased, with low levels of myofibre necrosis in adults. However, from about 3 weeks of post-natal age, muscles of juvenile mdx mice undergo an acute bout of severe necrosis and inflammation: this subsequently decreases and stabilises to lower adult levels by about 6 weeks of age. Prior to the onset of this severe dystropathology, we have shown that mdx mice are deficient in the amino acid taurine (potentially due to weaning), and we propose that this exacerbates myofibre necrosis and inflammation in juvenile mdx mice...
April 29, 2016: PLoS Currents
https://www.readbyqxmd.com/read/27669196/non-invasive-assessment-of-skeletal-muscle-myosin-heavy-chain-expression-in-trained-and-untrained-men
#13
Andrew C Fry, Terry J Housh, Joel B Cramer, Joseph P Weir, Travis W Beck, Brian K Schilling, Jonathan D Miller, Justin X Nicoll
Numerous conditions and types of physical activity (e.g., exercise, aging, muscle-related diseases) can influence muscle fiber types and the proteins expressed. To date, muscle fibers can only be characterized by actually obtaining a tissue sample using the invasive muscle biopsy procedure. Mechanomyography (MMG) is the assessment of the vibration properties of contracting skeletal muscle, and has been proposed as a possible non-invasive method for muscle fiber analysis. Therefore, the purpose of this project was to examine the feasibility of using MMG and muscle performance measures to non-invasively assess muscle fiber characteristics...
September 20, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27630760/mitochondria-in-the-aging-muscles-of-flies-and-mice-new-perspectives-for-old-characters
#14
REVIEW
Andrea Del Campo, Enrique Jaimovich, Maria Florencia Tevy
Sarcopenia is the loss of muscle mass accompanied by a decrease in muscle strength and resistance and is the main cause of disability among the elderly. Muscle loss begins long before there is any clear physical impact in the senior adult. Despite all this, the molecular mechanisms underlying muscle aging are far from being understood. Recent studies have identified that not only mitochondrial metabolic dysfunction but also mitochondrial dynamics and mitochondrial calcium uptake could be involved in the degeneration of skeletal muscle mass...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27619626/denervation-drives-mitochondrial-dysfunction-in-skeletal-muscle-of-octogenarians
#15
Sally Spendiff, Madhusudanarao Vuda, Gilles Gouspillou, Sudhakar Aare, Anna Perez, José A Morais, Robert T Jagoe, Marie-Eve Filion, Robin Glicksman, Sophia Kapchinsky, Norah MacMillan, Charlotte H Pion, Mylène Aubertin-Leheudre, Stefan Hettwer, José A Correa, Tanja Taivassalo, Russell T Hepple
Experimental denervation modulates mitochondrial function, where changes in both reactive oxygen species (ROS) and sensitivity to permeability transition are implicated in the resultant muscle atrophy. Notably, although denervation occurs sporadically in ageing muscle, its impact on ageing muscle mitochondria is unknown. As this information has important therapeutic implications concerning targeting the mitochondrion in ageing muscle, we examined mitochondrial function in skeletal muscle from four groups of humans, comprising two active (mean age 23...
September 13, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27616163/muscle-strength-postural-balance-and-cognition-are-associated-with-braking-time-during-driving-in-older-adults
#16
Angelica C Alonso, Mark D Peterson, Alexandre L Busse, Wilson Jacob-Filho, Mauricio T A Borges, Marcos M Serra, Natalia M S Luna, Paulo H Marchetti, Júlia M D A Greve
BACKGROUND: Despite the well-known declines in driving performance with advancing age, there is little understanding of the specific factors that predict changes in key determinants such as braking time. OBJECTIVES: The aims of this study were to determine the extent to which age, muscle strength, cognition and postural balance are associated with braking performance in middle-aged and older adults. METHODS: Male and female middle-aged adults (n=62, age=39...
September 8, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27612523/reversal-of-aged-muscle-stem-cell-dysfunction
#17
James W Larrick, Jasmine W Larrick, Andrew R Mendelsohn
The loss of muscle stem cell (MuSC) numbers and function in the elderly results in a dramatic delay or incomplete repair of muscle following injury or surgery. Prolonged immobility can exacerbate the loss of muscle mass with increased morbidity of affected patients. Stem cells and their niche cooperate to regulate the activation, self-renewal, differentiation, and return to quiescence of MuSCs. Extracellular matrix fibronectin (FN) and MuSC β1-integrin have been identified as critical factors in the dysfunction of aging muscle...
October 11, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/27592133/recovery-from-muscle-weakness-by-exercise-and-fes-lessons-from-masters-active-or-sedentary-seniors-and-sci-patients
#18
Ugo Carraro, Helmut Kern, Paolo Gava, Christian Hofer, Stefan Loefler, Paolo Gargiulo, Kyle Edmunds, Íris Dröfn Árnadóttir, Sandra Zampieri, Barbara Ravara, Francesco Gava, Alessandra Nori, Valerio Gobbo, Stefano Masiero, Andrea Marcante, Alfonc Baba, Francesco Piccione, Sheila Schils, Amber Pond, Simone Mosole
Many factors contribute to the decline of skeletal muscle that occurs as we age. This is a reality that we may combat, but not prevent because it is written into our genome. The series of records from World Master Athletes reveals that skeletal muscle power begins to decline at the age of 30 years and continues, almost linearly, to zero at the age of 110 years. Here we discuss evidence that denervation contributes to the atrophy and slowness of aged muscle. We compared muscle from lifelong active seniors to that of sedentary elderly people and found that the sportsmen have more muscle bulk and slow fiber type groupings, providing evidence that physical activity maintains slow motoneurons which reinnervate muscle fibers...
September 3, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27561813/latent-mitochondrial-dna-deletion-mutations-drive-muscle-fiber-loss-at-old-age
#19
Allen Herbst, Jonathan Wanagat, Nashwa Cheema, Kevin Widjaja, Debbie McKenzie, Judd M Aiken
With age, somatically derived mitochondrial DNA (mtDNA) deletion mutations arise in many tissues and species. In skeletal muscle, deletion mutations clonally accumulate along the length of individual fibers. At high intrafiber abundances, these mutations disrupt individual cell respiration and are linked to the activation of apoptosis, intrafiber atrophy, breakage, and necrosis, contributing to fiber loss. This sequence of molecular and cellular events suggests a putative mechanism for the permanent loss of muscle fibers with age...
August 25, 2016: Aging Cell
https://www.readbyqxmd.com/read/27541089/the-relationship-between-dynamic-balance-and-postrotary-nystagmus-in-learning-disabled-children
#20
S J Clyse, M A Short
Twenty-four children with learning disabilities or perceptual-motor handicaps were evaluated using the Southern California Postrotary Nystagmus Test and other clinical measures frequently used by occupational therapists to assess vestibular function. Correlational analyses revealed significant relationships between nystagmus duration scores and Walk on Floor Eyes Closed (a test of dynamic balance), prone extension posture, Walk on Floor Eyes Open, age, muscle tone and Standing Balance: Eyes Open. Multiple regression analysis indicated that when all of the clinical variables were considered together, the Walk on Floor Eyes Closed test was the best predictor of postrotary nystagmus duration...
1983: Physical & Occupational Therapy in Pediatrics
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