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evaluation of serum ferritin after blood transfusion

Tsutomu Nakamura, Minoru Takahashi, Riho Niigata, Kazuhiko Yamashita, Manabu Kume, Midori Hirai, Hiroyuki Yasui
The administration of cisplatin (CDDP) may influence trace metal concentrations in body fluids. In order to test this hypothesis, the blood concentrations of trace metals were determined during the present study in eight Japanese esophageal and lung cancer patients receiving CDDP-based chemotherapy. The levels of manganese, iron (Fe), cobalt, copper, zinc (Zn), platinum and lead in the plasma were determined by inductively coupled plasma-mass spectrometry. In addition, the serum levels of Fe, transferrin and ferritin were evaluated...
December 2016: Biomedical Reports
James C Barton, Wen-Pin Chen, Mary J Emond, Pradyumna D Phatak, V Nathan Subramaniam, Paul C Adams, Lyle C Gurrin, Gregory J Anderson, Grant A Ramm, Lawrie W Powell, Katrina J Allen, John D Phillips, Charles J Parker, Gordon D McLaren, Christine E McLaren
BACKGROUND: GNPAT p.D519G positivity is significantly increased in HFE p.C282Y homozygotes with markedly increased iron stores. We sought to determine associations of p.D519G and iron-related variables with iron stores in p.C282Y homozygotes. METHODS: We defined markedly increased iron stores as serum ferritin >2247pmol/L (>1000μg/L) and either hepatic iron >236μmol/g dry weight or iron >10g by induction phlebotomy (men and women). We defined normal or mildly elevated iron stores as serum ferritin <674...
November 12, 2016: Blood Cells, Molecules & Diseases
Lisette Del Corso, Lucia Biale, Emanuele Luigi Parodi, Rodolfo Russo, Rosa Filiberti, Eleonora Arboscello
BACKGROUND: Deferasirox (DFX) is used to reduce iron levels in patients with myelodysplastic syndrome (MDS) who develop iron overload after chronic red blood cell infusions. However, DFX can be associated with renal and gastrointestinal toxicities, which may cause treatment interruption or discontinuation. This study aimed to determine the effectiveness and safety of DFX in patients with MDS. METHODS: This multicenter, retrospective, observational study was conducted at two hospitals in Italy...
October 22, 2016: International Journal of Clinical Oncology
Mehran Karimi, Abbas Avazpour, Sezaneh Haghpanah, Foroogh Toosi, Arash Badie
BACKGROUND: β-thalassemia is the most common heredity disease in Iran. Regular blood transfusion is critical to sustain life and normal growth. Deferasirox is an oral chelator. One of the side effects of the deferasirox is proteinuria. OBJECTIVES: This study aimed to investigate the safety of deferasirox on kidney function in diabetic and nondiabetic β-thalassemia major patients. MATERIALS AND METHODS: In this cross-sectional study, 34 diabetic and 36 nondiabetic patients who take deferasirox (Exjade) 20 to 40 mg/kg/d were studied...
January 2017: Journal of Pediatric Hematology/oncology
Li Huang, Hong-Xia Yao
OBJECTIVE: To investigate the clinical features of β-thalassaemia intermediate (TI) patients and the curative effect and side reactions of hydroxyurea therapys. METHODS: Twenty nine patients with TI were divided into hydroxyurea therapy group and no hydroxyurea therapy group; the curative effect and side reactions in 2 groups were compared; the situation of blood transfusion in the 2 groups was evaluated. RESULTS: In hydroxyurea therapy group, the hemoglobin level increased after treatment for 3 months; the reticulocyte percentage obviously decreased after treatment for 12 months; the serum ferritin had been maintained at a low level; while in no hydroxyurea therapy group, the levels of hemoglobin and reticulocytes were not significantly improved after treatment, the serum ferritin level gradually increased...
June 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
Lei Ye, Liping Jing, Guangxin Peng, Kang Zhou, Yang Li, Yuan Li, Jianping Li, Huihui Fan, Wenrui Yang, Fengkui Zhang, Li Zhang
OBJECTIVE: To explore the effects of serum ferritin (SF) and iron overload (IO) pre-immunosupressive treatment (IST) on hematologic response of severe aplastic anemia (SAA/VSAA) patients treated with IST. METHODS: 257 SAA/VSAA patients who underwent first-line IST from Feb, 2003 to Dec, 2011 in Anemia Therapeutic Centre, Institute of Hematology and Blood Diseases Hospital were retrospectively analyzed, the status of SF before IST and the IO-affected factors were studied...
April 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Jacky Herzlich, Ita Litmanovitz, Rivka Regev, Sofia Bauer, Gisela Sirota, Zvi Steiner, Shmuel Arnon
AIM: To evaluate the short-term effects of blood transfusion on iron status [hemoglobin, ferritin, soluble transferrin receptor (sTfR), and reticulocyte count], hepcidin, and erythropoietin in stable preterm infants. METHOD: Sixty-three preterm infants treated with red blood cell transfusions (RBCTs) were included. Venous blood samples were collected before and within 24 h after each transfusion. RESULTS: Hemoglobin concentration increased after RBCT (7...
October 1, 2016: Journal of Perinatal Medicine
Shahrzad Riahi, I Lai Mei, Fariddh Binti Idris, Elizabeth George, Sabariah Md Noor
Pre-donation screening declarations and hemoglobin (Hb) testing are measures used to determine the quality of donated blood. The copper sulphate (CuSo4) method used to screen for blood abnormalities can give inaccurate results if strict quality control is not applied. Blood donors who are carriers of thalassemia and those with mild iron deficiency anemia (IDA) are usually asymptomatic and frequently missed at blood donation. The aim of this study was to evaluate the red blood cell (RBC) indices related disorders among blood donors who were deemed qualified to donate blood after screening with CuSo4 method...
September 2015: Southeast Asian Journal of Tropical Medicine and Public Health
Kristen Plantz, Elizabeth Maxwell, Petar Mamula, Robert Baldassano, Ronen Stein
BACKGROUND: Iron deficiency anemia (IDA) is a common complication of pediatric inflammatory bowel disease (IBD). The effectiveness of oral iron supplementation in the treatment of IDA is limited by its slow onset of action, daily dosing, gastrointestinal side effects, and potential for exacerbation of intestinal inflammation. Intravenous iron sucrose (IS) is an effective and safe alternative treatment for IDA in adults with IBD, but its role in the treatment of IDA in pediatric IBD is unclear...
March 2016: Inflammatory Bowel Diseases
Vincenzo De Sanctis, Heba Elsedfy, Ashraf T Soliman, Ihab Zaki Elhakim, Alessia Pepe, Christos Kattamis, Nada A Soliman, Rania Elalaily, Mohamed El Kholy, Mohamed Yassin
INTRODUCTION: In males, acquired hypogonadotropic hypogonadism (AHH) includes all disorders that damage or alter the function of gonadotropin-releasing hormone (GnRH) neurons and/or pituitary gonadotroph cells. The clinical characteristics of AHH are androgen deficiency and lack, delay or halt of pubertal sexual maturation. AHH lead to decreased libido, impaired erectile function, and strength, a worsened sense of well-being and degraded quality of life (QOL). PATIENTS AND METHODS: We studied 11 adult men with thalassemia major (TM) aged between 26 to 54 years (mean ± SD: 34...
2016: Mediterranean Journal of Hematology and Infectious Diseases
Hsiu-Hao Chang, Meng-Yao Lu, Steven Shinn-Forng Peng, Yung-Li Yang, Dong-Tsamn Lin, Shiann-Tarng Jou, Kai-Hsin Lin
Deferasirox is a novel once-daily, oral iron chelator. The aim of this study was to evaluate the long-term efficacy and tolerability of deferasirox in Taiwanese patients with transfusion-dependent β-thalassemia who have been treated with deferasirox for 7 years. Taiwanese patients aged ≥2 years with transfusion-dependent β-thalassemia whose serum ferritin levels were ≥1000 ng/mL and had started deferasirox treatment since December 2005 at the National Taiwan University Hospital were enrolled. Sixty patients were recruited for analysis, and 11 (18...
December 2015: Annals of Hematology
Qian Zhang, Bo Hou, Lu Wang, Yali Du, Bing Han, Feng Feng
OBJECTIVE: To use the technique of magnetic resonance imaging (MRI) T2* mapping to diagnose and follow-up of patients with iron overload. METHODS: 107 patients who were suspected to have iron overload between 2011.7-2014.3 in Peking Union Medical Colleague Hospital were analyzed retrospectively. Patients had the document of MRI T2* value of liver, heart and pancreas, serum ferritin (SF), transferrin saturation (TS), transfusion amount and other related laboratory tests...
April 2015: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Mika Nakamae, Hirohisa Nakamae, Shiro Koh, Hideo Koh, Mitsutaka Nishimoto, Yasuhiro Nakashima, Takahiko Nakane, Asao Hirose, Masayuki Hino
Little research has been done on changes in serum ferritin (s-ferritin) levels and clinical implications following allogeneic hematopoietic cell transplantation (HCT). We retrospectively evaluated the correlation of s-ferritin levels after HCT with survival in 203 patients. The s-ferritin level was significantly elevated, with 75% of the patients showing peak levels 90 days after HCT. The level was >10,000 ng/ml in a total of 43% of the patients, a finding that was associated with febrile neutropenia or infection...
2015: Acta Haematologica
Nonlawan Chueamuangphan, Jayanton Patumanond, Wattana Wongtheptien, Weerasak Nawarawong, Apichard Sukonthasarn, Suporn Chuncharunee, Chamaiporn Tawichasri
OBJECTIVE: The aim of the research reported here was to compare pulmonary artery systolic pressure (PASP) and 6-minute walk distance after 1 year of follow-up in hemoglobin E/β thalassemia (E/β-Thal) with pulmonary arterial hypertension (PAH) patients who received chronic blood transfusions versus those who received occasional transfusions. METHODS: A nonrandomized clinical trial was conducted at the Hematological Outpatient Clinic of Chiang Rai Hospital, Thailand...
2014: International Journal of General Medicine
Amal El-Beshlawy, Mona El-Ghamrawy, Mona Abou EL-Ela, Fadwa Said, Sonia Adolf, Abdel-Rahman Ahmed Abdel-Razek, Rania Ismail Magdy, Amina Abdel-Salam
Hydroxycarbamide (hydroxyurea or HU) has been shown to increase fetal hemoglobin (HbF) in patients with β-thalassemia intermedia (TI). The reported effects of HU in increasing the total hemoglobin (Hb) have been inconsistent. Studies of long-term therapy with HU in pediatric TI are rather uncommon. A retrospective observational study was carried out to evaluate the clinical responses to HU in Egyptian patients with β-TI. One hundred patients; children (n = 82, mean age 9.9 ± 4.1 years) and adults (n = 18) were studied for the mean Hb, HbF%, median serum ferritin, transfusion history, and splenic size before and after HU therapy (mean dose 20...
December 2014: Annals of Hematology
Emanuele Angelucci, Valeria Santini, Anna Angela Di Tucci, Giulia Quaresmini, Carlo Finelli, Antonio Volpe, Giovanni Quarta, Flavia Rivellini, Grazia Sanpaolo, Daniela Cilloni, Flavia Salvi, Giovanni Caocci, Alfredo Molteni, Daniele Vallisa, Maria Teresa Voso, Susanna Fenu, Lorenza Borin, Giancarlo Latte, Giuliana Alimena, Sergio Storti, Alfonso Piciocchi, Paola Fazi, Marco Vignetti, Sante Tura
BACKGROUND: In the absence of randomized, controlled trial data to support iron chelation therapy in transfusion-dependent patients with myelodysplastic syndromes (MDS), continued evidence from large prospective clinical trials evaluating the efficacy and safety of iron chelation therapy in this patient population is warranted. METHODS: The safety and efficacy of deferasirox was examined in a prospective, open-label, single-arm, multicenter trial of transfusion-dependent patients with International Prognostic Scoring System low- or intermediate-1-risk MDS and evidence of transfusion-related iron overload...
June 2014: European Journal of Haematology
Kadie M Anderson, Karen N Wolf
CASE DESCRIPTION: A 16-year-old vasectomized male ring-tailed lemur (Lemur catta) with a history of suspected chronic renal failure was evaluated because of extreme lethargy, hyperpnea, and abscess of the right pectoral scent gland. CLINICAL FINDINGS: Examination of the anesthetized patient revealed an impacted right pectoral scent gland with serosanguineous exudate. A CBC and serum biochemical analysis revealed severe anemia, marked azotemia, hyperphosphatemia, and hypocalcemia...
February 15, 2014: Journal of the American Veterinary Medical Association
Samin Alavi, Maryam Ebadi, Farid Ghazizadeh, Mohammad Taghi Arzanian, Bibishahin Shamsian, Fatemeh Abdollah Gorji
INTRODUCTION: Herein, the results of a prospective study evaluating the efficacy and safety of treatment with deferasirox are studied in iron-overloaded patients with β-thalassemia major during an 18-month trial. METHODS: Thirty patients who were previously chelated with deferoxamine with/without deferiprone, and fulfilled the inclusion criteria were recruited. Patients received an initial dose of 10-30 mg/kg/day. Liver and cardiac MRI T2* were evaluated before and after the trial...
February 2014: Pediatric Hematology and Oncology
Ali Malekshahi Moghadam, Mahboobeh Mehrabani Natanzi, Mahmoud Djalali, Ahmad Saedisomeolia, Mohammad Hassan Javanbakht, Ali Akbar Saboor-Yaraghi, Mahnaz Zareei
CONTEXT AND OBJECTIVE: Regular blood donation may decrease body iron storage and lead to anemia. The aim here was to evaluate the iron status of Iranian male blood donors and the impact of age, body mass index (BMI) and donation frequency over one year, on iron status indices. DESIGN AND SETTING: Cross-sectional, descriptive and analytical study at Tehran Blood Transfusion Center, Tehran, Iran. METHODS: Between July and September 2011, 117 male blood donors were selected and divided into four groups according to their frequency of blood donation...
2013: São Paulo Medical Journal, Revista Paulista de Medicina
Ahmed El Saiid Hamed, Iman Ahmed Ragab, Terez Boshra Kamel, Alia Osama Ali Abd-El-Gawad
UNLABELLED: In settings of limited health resources, using leukocyte-filtered blood is limited to patients with leukocyte-mediated complications. The aim of this study was to determine the patterns of lung dysfunction among patients with β-thalassemia major (BTM) after the application of the leukostop filter during transfusion for a period of 6 months. The study included 30 patients with transfusion-dependent BTM divided into two groups according to the use of leukocyte filter. Group I included 15 patients with BTM allocated to use the leukocyte filter before each blood transfusion for 6 months and group II included 15 patients with BTM using nonleukocyte-filtered blood...
November 2013: Pediatric Hematology and Oncology
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