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Ozge Akbulak, Ayse Serap Karadag, Necmettin Akdeniz, Seyma Ozkanli, Emin Ozlu, Ebru Zemheri, Serpil Oguztuzun
INTRODUCTION: Oxidative stress is the imbalance between oxidant-antioxidant systems and may play a major role in the psoriasis pathogenesis. Cytochrome (CYP) is a family of enzymes that are responsible for the metabolism of various endogenous and exogenous substances such as drug metabolism. Most importantly, the antioxidant system is the glutathione S-transferases (GST), which decrease oxidative stress by reducing oxidative products. AIM: We aimed to evaluate the expressions of isoenzymes of GST and CYP families and the beneficial role of metotrexate (MTX) in this process...
October 3, 2017: Cutaneous and Ocular Toxicology
Massimo Serra, Claudia Maria Hattinger
No abstract text is available yet for this article.
January 2017: Expert Opinion on Drug Metabolism & Toxicology
Sila Seremet, Sunil Abhyankar, Tiffany J Herd, Daniel Aires
INTRODUCTION: Extracorporeal photopheresis (ECP) has been used for the treatment of advanced stage or treatment refractory cutaneous T-cell lymphoma (CTCL) since 1987, and more recently has also been shown to be of benefit for earlier stage resistant CTCL. Complete response rates in prior studies of ECP in early CTCL have ranged from 0% to 40%. METHODS: We reviewed electronic medical records of all CTCL patients seen in the University of Kansas Cancer Center between June 2007 and May 2011...
October 1, 2016: Journal of Drugs in Dermatology: JDD
Patrizia Barone, Rossana Pignataro, Maria Teresa Garozzo, Salvatore Leonardi
IL-6 has a key role in the pathogenesis, clinical manifestations and activity of Systemic Onset Idiopathic Arthritis (sJIA). Tocilizumab (TCZ), the first humanized antihuman IL-6 receptor antibody, inhibits the activity of IL-6. In this review, we summarize the main studies performed, to date, about the use of TCZ in children affected by sJIA refractory to conventional treatment. Nowadays TCZ can be used, alone or in association with Metotrexate, in children older than 2 years. Its use in children younger than 2 years is being investigated...
2016: Immunotherapy
Marija Gamulin, Ira Pavlović Ruzić, Mislav Grgić, Marijana Jazvić, Mladen Solarić, Dag Zahirović, Robert Zorica, Tomislav Omrcen, Marija Petković, Mate Matić, Zeljko Fuckar, Boris Ruzić, Josip Pasini, Marijan Situm, Gordana Dordević, Damir Miletić, Tade Tadić, Zeljko Kastelan, Davor Librenjak, Ivan Gilja, Katarina Vilović, Bozo Kruslin, Hrvoje Kuvezdić
Urothelial cancer is the most common bladder cancer. Hematuria is the most common presenting symptom in patients with bladder cancer. The most common diagnostics of bladder cancer is performed by transurethral resection of bladder after which pathohistological diagnosis is set. It is necessary to determine whether the cancer penetrated in muscle layer (muscle-invasive cancer) or not (muscle-noninvasive cancer). Decision on therapeutic modality depends on the clinical stage of disease and on prognostic and risk factors...
November 2013: Lijec̆nic̆ki Vjesnik
Carolina Valeria Mahuad, Erica Rojas Bilbao, Gonzalo Martín Garate, María de Los Ángeles Vicente Repáraz, Mercedes Del Olmo, Claudia Érica Casali, Marta Elisa Zerga, Ana María Chirife, Juan Alberto Cicco
Since nasal NK/T-cell lymphoma and NK/T-cell lymphoma nasal type are rare diseases, colonic involvement has seldom been seen. We report a case of a patient with a primary NK/T-cell lymphoma nasal type of the colon. The patient had no history of malignant diseases and was diagnosed after exhaustive study in the context of fever of unknown origin. The first therapeutic approach followed the DA-EPOCH-protocol: etoposide, prednisone, doxor-rubicin, vincristine and cyclophosphamide. The persistence of constitutional symptoms after the first treatment course motivated the switch to a second line following the SMILE-protocol: dexamethasone, metotrexate, ifosfamide, E...
February 11, 2013: Rare Tumors
Branka Nikolić, Aleksandar Ljubić, Milan Terzić, Aleksandra Arandjelović, Srdjan Babić, Milos Vucić
INTRODUCTION: Choriocarcinoma is a malignant form of gestational trophoblastic neoplasm (GTN). It is a rare event but also a curable malignancy. In the majority of instancies it developes after any gestational event. In some cases it developes as non-gestational extrauterine malignancy. Prognosis of choriocarcinoma is poor when invasion and metastases appear early and spread fast. This form of choriocarcinoma can lead to incurable and letal outcome. CASE REPORT: We presented a 20-year-old patient with abdominal and retroperitoneal malignancy--anaplastic carcinoma combined with choriocarcinoma metastases in...
December 2012: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Laura Sabatini, Anna Barbieri, V Lodi, F S Violante
BACKGROUND: In view of the evidence of cytotoxicity of chemotherapic antineoplastic drugs (AD), current guidelines recommend the evaluation of the health risks of hospital personnel exposed to these compounds. Biological monitoring is the main tool to evaluate all possible drug intake and measure workers' real risk. OBJECTIVES: The aim of this study was to assess occupational exposure toAD in a large hospital in Northern Italy in order to verify the effectiveness of the structural and procedural improvements carried out over the last decade...
September 2012: La Medicina del Lavoro
Hugo Ferro, Eduardo Parino
A 27-year-old male patient presented with speech disorders and multiple brain masses on MRI evaluation. He tested positive for HIV. A sterotactic biopsy diagnosed primary central nervous system lymphoma (diffuse large B-cell lymphoma). After two cycles of high-dose metotrexate (HD-MTX-)-based chemotherapy, the tumor progressed. He underwent whole brain radiotherapy achieving complete response. Six cycles of consolidating immunochemotherapy with rituximab-temozolomide were administered after radiation. Forty-three months after remission, he has not recurred and his neurological status is optimal...
2012: Case Reports in Oncological Medicine
Branislava Glisić, Bojana Knezević
INTRODUCTION: Rituximab selectively targets CD20+ B cells and presumably protects joints in rheumatoid arthritis. Complete remissions after a single treatment with rituximab, in some cases for longer than 1 year, are observed in only the minority of patients. We reported a patient suffering from refractory rheumatoid arthritis who responded to rituximab with sustained remission. CASE REPORT: A 78-year-old woman was diagnosed with seropositive rheumatoid arthritis in 2001...
January 2012: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Darko Antic, Mihajlo Smiljanic, Jelena Bila, Snezana Jankovic, Milena Todorovic, Bosko Andjelic, Biljana Mihaljevic
A 60-year-old woman with no previous history of chronic disease or malignancy presented with intense back and left leg pain and sleep disturbances. The patient had been treated unsuccessfully for the past 6 months with analgetics. Magnetic resonance imaging showed a soft tissue tumor in the L5-S1 region that involved the spinal canal, and a pathohistological analysis of the tumor specimen confirmed the presence of non-Hodgkin, diffuse large B cell lymphoma. After the diagnosis was confirmed, malaise, nausea, and vomiting developed...
April 2012: Neurological Sciences
M Kazandi, V Turan
OBJECTIVE: The assessment of ectopic pregnancy, its risk factors and comparison of the treatment modalities. MATERIAL AND DESIGN: Between January 2002 and July 2009, 254 ectopic pregnancies were reviewed retrospectively at the Department of Obstetrics and Gynecology, Ege University. Complaints of patients, localizations of ectopic pregnancy and comparison of patients, whether they had medical therapy or surgery, were evaluated. Metotrexate (50 mg/m2 IM) was used in hemodinamically stable patients (hCG concentrations of patients varied between 450 IU/1 and 3660 IU/1)...
2011: Clinical and Experimental Obstetrics & Gynecology
Olga Ferreira, Ana Filipa Duarte, Teresa Baudrier, Alberto Mota, Joana Sobrinho Simões, Filomena Azevedo
There are no pathognomonic findings for cutaneous infection caused by Mycobacterium chelonae. The type and duration of therapy varies considerably among reports and no single antibiotic is considered the treatment of choice. A 61-year-old patient, suffering from rheumatoid arthritis (treated with metotrexate and salazopyrine), presented with violaceous nodules of the right leg that had been evolving for 6 months. She was underwent several skin biopsies. Tissue culture of the last showed an atypical mycobacteria, identified as M...
April 15, 2010: Dermatology Online Journal
Sekib Sokolović, Sida Kasumagić
A very rare inflammatory systemic rheumatic disorder--Multicentric reticulohistiocytosis--was described as a case report in this paper. A 22 year old female patient was presented with a destructive polyarthritis and prominent multiple skin nodules that pointed to possible presence of this rare disease. The final diagnosis was made based on the biopsy finding. Application of the cytotoxic drug Metotrexate in the therapy, besides non-steroidal anti-inflammatory drugs and corticosteroids, leaded to full remission with disappearance of skin changes...
2009: Medicinski Arhiv
María M Katsicas, Ricardo A G Russo
To analyse the effectiveness and safety of adalimumab in a group of patients with juvenile idiopathic arthritis (JIA) who had failed treatment with etanercept and/or infliximab in a single paediatric rheumatology clinic. Patients with JIA with active polyarthritis refractory to metotrexate (MTX) (> or =20 mg/m2/week) for at least 3 months and to etanercept (up to 1 mg/kg twice weekly) and/or infliximab (up to 10 mg/kg every 4 weeks) for at least 6 months were included. All patients received adalimumab 24 mg/m2/week concomitantly with MTX 7...
August 2009: Clinical Rheumatology
Marie Ahnström Waltersson, Marie Stenmark Askmalm, Bo Nordenskjöld, Tommy Fornander, Lambert Skoog, Olle Stål
Cyclin E and the retinoblastoma protein (Rb) are both important regulators of the G1 phase in the cell cycle. Overexpression of cyclin E and lost expression of Rb has previously been observed in breast tumours at frequencies of 10-50% and 20-30%, respectively. We explored the prognostic role of cyclin E and Rb in breast cancer patients randomised for tamoxifen (TAM), CMF (cyclophosphamide, metotrexate, 5-fluorouracil) chemotherapy and radiotherapy (RT) and how their expression affects the patients' response to treatment...
February 2009: International Journal of Oncology
Grazyna Krzemień, Agnieszka Szmigielska, Iwona Bieroza, Maria Roszkowska-Blaim
Acute renal failure (ARF), which is diagnosed in 3.4-20% of newborns, is polyetiological in most cases. We present a newborn with non-oliguric ARF diagnosed in the first day of life, and caused by asphixia, intrauterine infection (IUI) and nephrotoxic effects of metotrexate treatment during pregnancy. Antibiotics, including netilmicin and vankomycin, were given because of IUI and infected central venous catheter. Dosage of drugs was adjusted to renal failure parameters, but monitoring of their serum levels was not available...
2008: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Mevludin Mekić, Miomir Ristić
Rheumatoid arthritis is a chronic systematic inflammation illness characterized by progressive damage of joints. Treatment of rheumatoid arthritis is individual, programmed and complex and consists of general measures, application of adequate medication, physical procedures, balneotherapy and various surgical techniques as necessary. The objective of research is to show success of therapy in use of medication and other types of treatment for patients suffering from rheumatoid arthritis. The following were applied: non-steroid anti-inflammatory medications (NAIL), metotrexate, gold salts, corticosteroids, sulphasalzine, Chlorochin, cyclophosphamide and others...
2008: Medicinski Arhiv
Ana Paula Negreiros Nunes Alves, Cláudia do O Pessoa, Letícia Costa-Lotufo, Manoel Odorico Moraes Filho
PURPOSE: To investigate the effects of bisphosphosnate alendronate (ALD) and metotrexate (MTX) on an experimental model of Walker 256 carcinosarcoma developed in the oral cavity of rats. METHODS Walker 256 carcinosarcoma cell suspension (0,1 mL) containing 10(6) cell/mL was implanted in the alveoli of the first and second molars. The animals were divided and treated with saline, MTX, ALD, and MTX plus ALD. Later, the animals were sacrificed, the tumors were measured and the mandibles were removed for radiographic and histological analysis...
November 2007: Acta Cirúrgica Brasileira
Marcella Mottolese, Giulia Orlandi, Isabella Sperduti, Roberta Merola, Simonetta Buglioni, Anna Di Benedetto, Paola Pinnarò, Letizia Perracchio, Irene Venturo, Francesco Cognetti, AnnaMaria Cianciulli
We aimed at developing a more detailed understanding of cyclin D1 in early stage human breast cancer and defining the biologic profiles with different prognostic value correlating cyclin D1 gene amplification and chromosome 11 aneusomy with bio-pathologic variables of known clinical importance. Cyclin D1 gene amplification and chromosome 11 aneusomy were investigated using fluorescence in situ hybridization whereas cyclin D1, PgR, HER-2, Bcl2, p53, and Ki-67 expressions were analyzed by immunohistochemistry in 121 stage I or II breast cancer patients uniformly treated with cyclophosphamide/metotrexate/5-fluorouracil-based chemotherapy...
February 2007: American Journal of Surgical Pathology
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