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https://www.readbyqxmd.com/read/29784012/treatment-of-experimental-colitis-by-endometrial-regenerative-cells-through-regulation-of-b-lymphocytes-in-mice
#1
Xiaoxi Xu, Yong Wang, Baoren Zhang, Xu Lan, Shanzheng Lu, Peng Sun, Xiang Li, Ganggang Shi, Yiming Zhao, Hongqiu Han, Caigan Du, Hao Wang
BACKGROUND: Endometrial regenerative cells (ERCs), a novel type of mesenchymal-like stem cell derived from menstrual blood, have been recently evaluated as an attractive candidate source in ulcerative colitis (UC); however, the mechanism is not fully understood. The present study was designed to investigate the effects of ERCs, especially on B-cell responses in UC. METHODS: In this study, colitis was induced by administering 3% dextran sodium sulfate (DSS) via free drinking water for 7 days to BALB/c mice...
May 22, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29774025/co-stimulation-impaired-bone-marrow-derived-dendritic-cells-prevent-dextran-sodium-sulfate-induced-colitis-in-mice
#2
Carl Engman, Yesica Garciafigueroa, Brett Eugene Phillips, Massimo Trucco, Nick Giannoukakis
Dendritic cells (DC) are important in the onset and severity of inflammatory bowel disease (IBD). Tolerogenic DC induce T-cells to become therapeutic Foxp3+ regulatory T-cells (Tregs). We therefore asked if experimental IBD could be prevented by administration of bone marrow-derived DC generated under conventional GM-CSF/IL-4 conditions but in the presence of a mixture of antisense DNA oligonucleotides targeting the primary transcripts of CD40, CD80, and CD86. These cell products (which we call AS-ODN BM-DC) have demonstrated tolerogenic activity in preventing type 1 diabetes and preserving beta cell mass in new-onset type 1 diabetes in the NOD mouse strain, in earlier studies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29765931/decreased-breg-th17-ratio-improved-the-prognosis-of-patients-with-ulcerative-colitis
#3
Xue Bing, Liang Linlang, Chen Keyan
Objective: To investigate the effects of regulatory B (Breg) cells and T helper 17 (Th17) cells on pathogenesis of ulcerative colitis, explore the clinical significance of Breg/Th17 ratio on the prognosis of ulcerative colitis, and provide the theoretical basis for the targeted therapy, diagnosis, and prognosis of the disease. Methods: Peripheral blood and colonic mucosa were collected from patients with ulcerative colitis. Hematoxylin-eosin staining was used to observe the pathological changes of colonic mucosa...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29760693/treatment-intensification-in-hiv-infected-patients-is-associated-with-reduced-frequencies-of-regulatory-t-cells
#4
Eva M Grützner, Tanja Hoffmann, Eva Wolf, Elke Gersbacher, Ashley Neizert, Renate Stirner, Ramona Pauli, Albrecht Ulmer, Jürgen Brust, Johannes R Bogner, Hans Jaeger, Rika Draenert
In untreated HIV infection, the efficacy of T cell responses decreases over the disease course, resulting in disease progression. The reasons for this development are not completely understood. However, immunosuppressive cells are supposedly crucially involved. Treatment strategies to avoid the induction of these cells preserve immune functions and are therefore the object of intense research efforts. In this study, we assessed the effect of treatment intensification [=5-drug antiretroviral therapy (ART)] on the development of suppressive cell subsets...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29749583/il-35-a-new-immunomodulator-in-autoimmune-rheumatic-diseases
#5
REVIEW
Lazaros I Sakkas, Athanasios Mavropoulos, Carlo Perricone, Dimitrios P Bogdanos
IL-35 is a relatively new cytokine that emerges as an important immunomodulator. IL-35 belongs to IL-12 cytokine family that includes IL-12, IL-23, IL-27, and IL-35. These cytokines are heterodimers that share subunits and their receptors also share subunits. Whereas IL-12 and IL-23 are clearly proinflammatory cytokines, the role of IL-35 is less clear. In mice, IL-35 appears to be anti-inflammatory and to protect from autoimmune inflammatory diseases. IL-35 induces the expansion of a subset of regulatory T cells (Tregs) and Bregs and mediates their suppressive function and inhibits Th17 cells...
May 11, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29676070/analysis-of-peripheral-b-cell-subsets-in-patients-with-allergic-rhinitis
#6
Jing Luo, Huanhuan Guo, Zhuofu Liu, Tao Peng, Xianting Hu, Miaomiao Han, Xiangping Yang, Xuhong Zhou, Huabin Li
PURPOSE: Recent evidence suggests that B cells can both promote and inhibit the development and progression of allergic disease. However, the characteristics of B cell subsets in patients with allergic rhinitis (AR) have not been well documented. This study aimed to analyze the characteristics of B cell subsets in the peripheral blood of AR patients. METHODS: Forty-seven AR patients and 54 healthy controls were enrolled in this study, and the B cell subsets in peripheral blood of all subjects were analyzed by flow cytometry...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29665000/increased-killer-b-cells-in-chronic-hcv-infection-may-lead-to-autoimmunity-and-increased-viral-load
#7
Nasren Eiza, Eli Zuckerman, Matthias Carlebach, Tova Rainis, Yair Goldberg, Zahava Vadasz
BACKGROUND: B regulatory (Breg) cells are characterized by various membrane markers, and the secretion of different inhibitory cytokines. A new subset of Breg cells was identified as CD5hi Fas-ligand (FasL)hi. Their main reported role is to suppress anti-viral and anti-tumor immune responses and hence, they have been dubbed "killer" B cells. In this study, we aim to assess the role of these cells in chronic hepatitis C virus (HCV) infection, and determine if they contribute to the increased viral load and persistence of HCV and its related autoimmunity...
April 17, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29599908/regulatory-b-cells-induced-by-pancreatic-cancer-cell-derived-interleukin-18-promote-immune-tolerance-via-the-pd-1-pd-l1-pathway
#8
Yan Zhao, Ming Shen, Yecheng Feng, Ruizhi He, Xiaodong Xu, Yu Xie, Xiuhui Shi, Min Zhou, Shutao Pan, Min Wang, Xingjun Guo, Renyi Qin
Dysregulation of regulatory B cells (Bregs), a type of immunosuppressive lymphocyte, are associated with development of autoimmune diseases and cancers. Bregs produce immune tolerance-inducing cell surface molecules and tolerogenic cytokines (interleukin [IL]-10 and transforming growth factor-beta). We previously showed that levels of the inflammatory cytokine IL-18 were increased in patients with pancreatic cancer. In the present study study, we found that pancreatic cancer cell-derived IL-18 increases Breg-induced immunosuppression...
March 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29566367/defective-circulating-regulatory-b-cells-in-patients-with-dilated-cardiomyopathy
#9
Jiao Jiao, Yu-Zhi Lu, Ni Xia, Yi-Qiu Wang, Ting-Ting Tang, Shao-Fang Nie, Bing-Jie Lv, Ke-Jing Wang, Shuang Wen, Jing-Yong Li, Xing-Di Zhou, Yu-Hua Liao, Xiang Cheng
BACKGROUND/AIMS: Newly identified IL-10-producing regulatory B cells (Bregs) have been shown to play an important role in the suppression of immune responses. Chronic immune activation participates in the pathogenesis of dilated cardiomyopathy (DCM) but whether Bregs are involved in its development remains unclear. We aimed to investigate the circulating frequency and function of Bregs in DCM. METHODS: In total, 35 DCM patients (20 men and 15 women) and 44 healthy controls (23 men and 21 women) were included in the experiment, and the frequency of Bregs was detected using flow cytometry...
March 20, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29531131/potential-role-for-regulatory-b-cells-as-a-major-source-of-interleukin-10-in-spleen-from-plasmodium-chabaudi-infected-mice
#10
Xue Han, Ji Yang, Yitong Zhang, Yalin Zhang, Hongtao Cao, Yaming Cao, Zanmei Qi
Interleukin-10 (IL-10)-producing regulatory B (Breg) cells were found to be induced in a variety of infectious diseases. However, its importance in the regulation of immune response to malaria is still unclear. Here, we investigated the dynamics, phenotype, and function of Breg cells using Plasmodium chabaudi chabaudi AS-infected C57BL/6 and BALB/c mice. BALB/c mice were more susceptible to infection and had a stronger IL-10 response in spleen than C57BL/6 mice. Analysis of the surface markers of IL-10-producing cells with flow cytometry showed that CD19+ B cells were one of the primary IL-10-producing populations in P...
May 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29529042/protease-signaling-through-protease-activated-receptor-1-mediate-nerve-activation-by-mucosal-supernatants-from-irritable-bowel-syndrome-but-not-from-ulcerative-colitis-patients
#11
Sabine Buhner, Hannes Hahne, Kerstin Hartwig, Qin Li, Sheila Vignali, Daniela Ostertag, Chen Meng, Gabriele Hörmannsperger, Breg Braak, Christian Pehl, Thomas Frieling, Giovanni Barbara, Roberto De Giorgio, Ihsan Ekin Demir, Güralp Onur Ceyhan, Florian Zeller, Guy Boeckxstaens, Dirk Haller, Bernhard Kuster, Michael Schemann
BACKGROUND & AIMS: The causes of gastrointestinal complaints in irritable bowel syndrome (IBS) remain poorly understood. Altered nerve function has emerged as an important pathogenic factor as IBS mucosal biopsy supernatants consistently activate enteric and sensory neurons. We investigated the neurally active molecular components of such supernatants from patients with IBS and quiescent ulcerative colitis (UC). METHOD: Effects of supernatants from 7 healthy controls (HC), 20 IBS and 12 UC patients on human and guinea pig submucous neurons were studied with neuroimaging techniques...
2018: PloS One
https://www.readbyqxmd.com/read/29523310/killer-fasl-regulatory-b-cells-are-present-during-latent-tb-and-are-induced-by-bcg-stimulation-in-participants-with-and-without-latent-tuberculosis
#12
Ilana C van Rensburg, Andre G Loxton
Regulatory B cells (Bregs) have been shown to be present during several disease states. The phenotype of the cells is not completely defined and the function of these cells differ between disease. The presence of FASL expressing (killer) B cells during latent and successfully treated TB disease have been shown but whether these cells are similar to regulatory B cells remain unclear. We assessed the receptor expression of FASL/IL5 (killer B cells), CD24/CD38 (regulatory B cells) on whole peripheral blood of participants with untreated active TB and healthy controls...
January 2018: Tuberculosis
https://www.readbyqxmd.com/read/29507629/mesenchymal-stem-cells-derived-exosomes-are-more-immunosuppressive-than-microparticles-in-inflammatory-arthritis
#13
Stella Cosenza, Karine Toupet, Marie Maumus, Patricia Luz-Crawford, Olivier Blanc-Brude, Christian Jorgensen, Danièle Noël
Objectives: Mesenchymal stem cells (MSCs) release extracellular vesicles (EVs) that display a therapeutic effect in inflammatory disease models. Although MSCs can prevent arthritis, the role of MSCs-derived EVs has never been reported in rheumatoid arthritis. This prompted us to compare the function of exosomes (Exos) and microparticles (MPs) isolated from MSCs and investigate their immunomodulatory function in arthritis. Methods: MSCs-derived Exos and MPs were isolated by differential ultracentrifugation. Immunosuppressive effects of MPs or Exos were investigated on T and B lymphocytes in vitro and in the Delayed-Type Hypersensitivity (DTH) and Collagen-Induced Arthritis (CIA) models...
2018: Theranostics
https://www.readbyqxmd.com/read/29500914/crosstalk-between-mesenchymal-stem-cells-and-t-regulatory-cells-is-crucially-important-for-the-attenuation-of-acute-liver-injury
#14
Marina Gazdic, Bojana Simovic Markovic, Aleksandar Arsenijevic, Nemanja Jovicic, Aleksandar Acovic, C Randall Harrell, Crissy Fellabaum, Valentin Djonov, Nebojsa Arsenijevic, Miodrag L Lukic, Vladislav Volarevic
One of the therapeutic options for the treatment of fulminant hepatitis is repopulation of intrahepatic regulatory cells because their pool is significantly reduced during acute liver failure. Although it is known that mesenchymal stem cells (MSCs), which have beneficent effects in the therapy of fulminant hepatitis, may promote expansion of regulatory T cells (Tregs) and regulatory B cells (Bregs), the role of these regulatory cells in MSC-mediated attenuation of acute liver injury is unknown. Herewith, we described the molecular mechanisms involved in the crosstalk between MSCs and liver regulatory cells and analyzed the potential of MSC-based therapy for the expansion of intrahepatic regulatory cells in mouse model of acute liver failure...
May 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29500500/-b-cells-in-head-and-neck-oncology
#15
REVIEW
P J Schuler, C Brunner, T K Hoffmann
As immunotherapy is becoming increasingly important in the treatment of head and neck cancer, a fundamental understanding of the immunological relationships in the tumor microenvironment is required. The importance of tumor-infiltrating B cells (TIL-B) has been largely neglected so far. In the current literature, however, a significant influence of B cells on tumor growth is described, so that this cell population is now also perceived as a therapeutic target structure. Regulatory B cells (Breg ) represent a subset of B cells with immunosuppressive properties...
April 2018: HNO
https://www.readbyqxmd.com/read/29494848/bacterially-activated-b-cells-drive-t-cell-differentiation-towards-tr1-through-pd-1-pd-l1-expression
#16
Sawsan Sudqi Said, Guliz Tuba Barut, Nesteren Mansur, Asli Korkmaz, Ayca Sayi-Yazgan
Regulatory B cells (Bregs) play a crucial role in immunological tolerance primarily through the production of IL-10 in many diseases including autoimmune disorders, allergy, infectious diseases, and cancer. To date, various Breg subsets with overlapping phenotypes have been identified. However, the roles of Bregs in Helicobacter infection are largely unknown. In the present study, we investigate the phenotype and function of Helicobacter -stimulated B cells. Our results demonstrate that Helicobacter felis -stimulated IL-10- producing B cells (Hfstim - IL-10+ B) are composed of B10 and Transitional 2 Marginal Zone Precursor (T2-MZP) cells with expression of CD9, Tim-1, and programmed death 1 (PD-1)...
April 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29474139/levels-of-regulatory-b-cells-do-not-predict-serological-responses-to-hepatitis-b-vaccine
#17
Maria Bolther, Karen Lise Dahl Andersen, Martin Tolstrup, Kumar Visvanathan, Ian Woolley, Narelle Skinner, Rosemary Millen, Nadia Warner, Lars Østergaard, Søren Jensen-Fangel
This study investigated the immunomodulatory influence of IL10 producing B regulatory cells, Bregs (CD19+CD24hiCD38hi) to standard Twinrix® vaccination. We also investigated HBsAg specific T-cell mediated IFN-γ responses to Twinrix® which in theory could provide effective immunity despite low anti-HBs titer. A total of 309 hepatitis B negative health care students and workers completed a standard Twinrix® vaccination schedule (0, 1 and 6 months). Depending on the vaccination response the participants were divided in to non-, low- and high responders according to anti-HBs titer (<10, <100 and >1000 mIU/mL respectively) two months after completed vaccination schedule...
February 23, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29464038/the-influence-of-chemotherapy-on-adenosine-producing-b-cells-in-patients-with-head-and-neck-squamous-cell-carcinoma
#18
Andreas Ziebart, Ulrich Huber, Sandra Jeske, Simon Laban, Johannes Doescher, Thomas K Hoffmann, Cornelia Brunner, Edwin K Jackson, Patrick J Schuler
Introduction: Head and neck squamous cell carcinoma (HNSCC) strongly suppresses the immune system, resulting in increased metastasis and recurrent disease. Chemotherapy is part of the multimodal treatment but may further immunosuppression. Recently, we demonstrated that regulatory B cells (Breg), defined as CD19+ CD39+ CD73+ B cells, play a significant role in the production of immunosuppressive, extracellular adenosine (ADO). Here, we tested the influence of chemotherapy on Breg function...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29450641/chronic-lymphocytic-leukemia-cells-acquire-regulatory-b-cell-properties-in-response-to-tlr9-and-cd40-activation
#19
Shimrit Ringelstein-Harlev, Irit Avivi, Mona Fanadka, Netanel A Horowitz, Tami Katz
Circulating chronic lymphocytic leukemia (CLL) cells share phenotypic features with certain subsets of regulatory B-cells (Bregs). The latter cells have been reported to negatively regulate immune cell responses, mostly by provision of IL-10. The purpose of the current study was to identify and delineate Breg properties of CLL cells. B-cells and T-cells were obtained from the peripheral blood of untreated CLL patients diagnosed according to the 2008 Guidelines of the International Workshop on Chronic Lymphocytic Leukemia...
May 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29449556/cd1d-dependent-immune-suppression-mediated-by-regulatory-b-cells-through-modulations-of-inkt-cells
#20
K Oleinika, E C Rosser, D E Matei, K Nistala, A Bosma, I Drozdov, C Mauri
Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function of CD1d in Breg biology and iNKT cell activity during inflammation remains unclear. Here we show, using chimeric mice, cell depletion and adoptive cell transfer, that CD1d-lipid presentation by Bregs induces iNKT cells to secrete interferon (IFN)-γ to contribute, partially, to the downregulation of T helper (Th)1 and Th17-adaptive immune responses and ameliorate experimental arthritis...
February 15, 2018: Nature Communications
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