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https://www.readbyqxmd.com/read/27878329/the-role-of-regulatory-b-cells-in-digestive-system-diseases
#1
REVIEW
Zhenyu Zhou, Lei Gong, Xiaoyun Wang, Zhen Hu, Gaojue Wu, Xuejun Tang, Xiaobin Peng, Shuan Tang, Miao Meng, Hui Feng
INTRODUCTION: The past decade has provided striking insights into a newly identified subset of B cells known as regulatory B cells (Bregs). In addition to producing antibody, Bregs also regulate diseases via cytokine production and antigen presentation. This subset of B cells has protective and potentially therapeutic effects. However, the particularity of Bregs has caused some difficulties in conducting research on their roles. Notably, human B10 cells, which are Bregs that produce interleukin 10, share phenotypic characteristics with other previously defined B cell subsets, and currently, there is no known surface phenotype that is unique to B10 cells...
November 22, 2016: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/27865860/human-regulatory-b-cells-control-tfh-response
#2
Achouak Achour, Quentin Simon, Audrey Mohr, Jean-François Séité, Pierre Youinou, Boutahar Bendaoud, Ibtissem Ghedira, Jacques-Olivier Pers, Christophe Jamin
BACKGROUND: Follicular helper T (Tfh) cells support the terminal B-cell differentiation. Human regulatory B (Breg) cells modulate cellular responses but their control of Tfh-dependent humoral immune responses is unknown. OBJECTIVE: To assess the role of Breg cells on Tfh development and function. METHODS: Human T cells were polyclonally stimulated in the presence of IL-12 and IL-21 to generate Tfh cells. They were co-cultured with B cells to induce their terminal differentiation...
November 16, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27825134/interleukin-13-suppresses-interleukin-10-via-inhibiting-a20-in-peripheral-b-cells-of-patients-with-food-allergy
#3
Ming-Yang Li, Min Zhu, En-Qiang Linghu, Fan Feng, Bing Zhu, Cheng Wu, Ming-Zhou Guo
The regulatory B cells (Breg) are important in the body immunity. The differentiation process of Breg is not fully understood yet. Ubiquitin A20 has immune regulatory functions. This study aims to investigate the role of A20 in the regulation of interleukin (IL)-10 in B cells. In this study, B cells were isolated from the peripheral blood samples of healthy subjects and patients with food allergy (FA). The B cells were analyzed by flow cytometry, real time RT-PCR, Western blotting and chromatin immunoprecipitation...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27821578/regulatory-b-cells-induce-formation-of-il-10-expressing-t-cells-in-mice-with-autoimmune-neuroinflammation
#4
Andrea Pennati, Spencer Ng, Yuanqiang Wu, Jordan R Murphy, Jiusheng Deng, Srikant Rangaraju, Seneshaw Asress, Jennifer L Blanchfield, Brian Evavold, Jacques Galipeau
: Although B cells are traditionally known for their role in propagating pro-inflammatory immune responses, their immunosuppressive effects have only begun to be recently appreciated. How these regulatory B cells (Bregs) suppress the immune response remains to be worked out in detail. In this paper we show that Bregs can induce formation of conventional FoxP3(+) regulatory T cells (Tregs), as well as a more recently described CD49b(+)CD223(+) regulatory T cell subset, known as type 1 regulatory T cells (Tr1)...
November 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27817178/roles-of-regulatory-t-and-b-cells-in-igg4-related-disease
#5
Kazushige Uchida, Kazuichi Okazaki
Immunoglobulin G4 (IgG4) -related disease (RD) is a newly recognized systemic disease. Although there are several forms of IgG4-RD reported under various names, depending on the target organ and characteristics, patients with IgG4-RD manifest several immunologic and histologic abnormalities including increased levels of serum IgG4 and storiform fibrosis with infiltration of lymphocytes and IgG4-positive plasmacytes in the involved organs. However, the pathophysiology remains unclear. Regulatory immune cells play an important role in several immune-related diseases...
November 6, 2016: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/27806875/immune-regulatory-effects-of-high-dose-vitamin-d3-supplementation-in-a-randomized-controlled-trial-in-relapsing-remitting-multiple-sclerosis-patients-receiving-ifn%C3%AE-the-solarium-study
#6
Anne-Hilde Muris, Joost Smolders, Linda Rolf, Marielle Thewissen, Raymond Hupperts, Jan Damoiseaux
Multiple sclerosis (MS) is characterized by a disturbed immune homeostasis and low serum vitamin D levels are associated with an increased disease activity. While vitamin D has been hypothesized to promote the maintenance of immune homeostasis, vitamin D supplementation could be of benefit to patients with MS. The SOLAR study investigated the effects of high dose vitamin D3 supplementation on clinical outcomes in a randomized controlled trial. Here we present the immune regulatory effects, investigated in the SOLARIUM sub-study...
November 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27782313/cytotoxic-ebv-positive-large-b-cell-lymphoma-a-breg-derived-neoplasia
#7
Valentina Tabanelli, Vanessa Santiago-Pacheco, Mario Corbellino, Angelica Calleri, Claudio Agostinelli, Carlo Parravicini, Stefano A Pileri
AIMS: A new subtype of granzyme B (GrB) producing "regulatory B cells" (Bregs) has been recently described; these peculiar cytotoxic B-cells are significantly increased in interleukin-21 (IL-21)-rich settings, and in particular during HIV and EBV infection. Our aim is to report a unique case of an EBV-positive diffuse large B-cell lymphoma (DLBCL) with cytotoxic features arisen in an HIV+ patient, and to understand if this lesion may represent a proliferation of neoplastic cytotoxic Bregs...
October 26, 2016: Histopathology
https://www.readbyqxmd.com/read/27762298/pd-l1-is-a-critical-mediator-of-regulatory-b-cells-and-t-cells-in-invasive-breast-cancer
#8
Honggeng Guan, Yuqiu Wan, Jing Lan, Qin Wang, Zhangyu Wang, Yecheng Li, Jiqing Zheng, Xueguang Zhang, Zemin Wang, Yueping Shen, Fang Xie
Regulatory T cells (Tregs), a key mediator in regulating anti-tumor immune suppression, tumor immune escape, metastasis and relapse, are considered an important therapeutic target in immunotherapy of human cancers. In the present investigation, elevated CD19(+) CD24(+) CD38(+) regulatory B cells (Bregs) were observed in PBMCs of invasive carcinoma of breast (IBCa) patients compared with that in patients with fibroadenoma (FIBma) or healthy individuals, and the positive correlation existed between Bregs and CD4(+) CD25(+) CD127(-) Tregs (r = 0...
October 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27752370/barrett-s-oesophagus-in-an-achalasia-patient-immunological-analysis-and-comparison-with-a-group-of-achalasia-patients
#9
Samuel Torres-Landa, Janette Furuzawa-Carballeda, Enrique Coss-Adame, Miguel A Valdovinos, Edgar Alejandro-Medrano, Bárbara Ramos-Ávalos, Braulio Martínez-Benítez, Gonzalo Torres-Villalobos
The aim of the study was to characterize the presence of diverse CD4 and CD8 T cell subsets and regulatory cells in peripheral blood and lower oesophageal sphincter (LES) from a young patient with BE/achalasia without treatment versus achalasia group. In order to characterize the circulating cells in this patient, a cytometric analysis was performed. LES tissue was evaluated by double-immunostaining procedure. Five healthy blood donors, 5 type achalasia patients, and 5 oesophagus tissue samples (gastrooesophageal junction) from transplant donors were included as control groups...
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27734415/the-immunobiology-of-interleukin-35-and-its-regulation-and-gene-expression
#10
Mei Song, Xiaojing Ma
Interleukin-35 (IL-35) is the latest addition to the IL-12 family of heterodimeric cytokines, consisting of IL-12 p35 subunit and IL-27β subunit Epstein-Barr virus induced 3 (EBI3). Since its discovery, IL-35 has been shown to exhibit immunosuppressive activities which are distinct from other members of IL-12 family. IL-35 is also unique in that it is expressed primarily by regulatory T-cells (Tregs) rather than by antigen-presenting cells (APCs). IL-35 can directly suppress effector T-cell proliferation and function and inhibit the differentiation of Th17 cells...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27693622/biosynthesis-purification-and-characterization-of-%C3%AE-1-4-xylanase-from-a-novel-mangrove-associated-actinobacterium-streptomyces-olivaceus-msu3-and-its-applications
#11
Muthusamy Sanjivkumar, TamilSelvan Silambarasan, Arunachalam Palavesam, Grasian Immanuel
The present study was undertaken to evaluate the xylanolytic properties of an actinobacterium Streptomyces olivaceus (MSU3) isolated from the sediment sample of mangrove environment. It showed highest xylanase activity on initial screening in Breg's mineral salts medium supplemented with 0.5% xylan. Further the organism expressed maximum xylanase production at optimized culture conditions of pH 7, temperature 30 °C with 2.5% of inoculum size at 72 h of incubation, the nutrient sources like sucrose (2%) and yeast extract (3%) have observed as best carbon and nitrogen sources respectively...
September 28, 2016: Protein Expression and Purification
https://www.readbyqxmd.com/read/27679683/immunomodulation-by-mesenchymal-stem-cells-interplay-between-mesenchymal-stem-cells-and-regulatory-lymphocytes
#12
EDITORIAL
Oscar Ka-Fai Ma, Koon Ho Chan
Mesenchymal stem cells (MSCs) possess immunomodulatory properties, which confer enormous potential for clinical application. Considerable evidence revealed their efficacy on various animal models of autoimmune diseases, such as multiple sclerosis, systemic lupus erythematosus and uveitis. MSCs elicit their immunomodulatory effects by inhibiting lymphocyte activation and proliferation, forbidding the secretion of proinflammatory cytokines, limiting the function of antigen presenting cells, and inducing regulatory T (Treg) and B (Breg) cells...
September 26, 2016: World Journal of Stem Cells
https://www.readbyqxmd.com/read/27670221/advances-in-the-pathophysiology-of-primary-immune-thrombocytopenia
#13
María Perera, Teresa Garrido
OBJECTIVES: Classically, immune thrombocytopenia (ITP) was thought to be caused by the destruction and insufficient production of platelets, as mediated by autoantibodies. More recently other immune mechanisms that contribute to the disease have been discovered. This review attempts to address the main unresolved questions in ITP. METHODS: We review the most current knowledge of the pathophysiology of ITP. Immunological effects of available therapies are also described...
September 27, 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/27665290/distinct-immunoregulatory-mechanisms-in-mesenchymal-stem-cells-role-of-the-cytokine-environment
#14
Vladimir Holan, Barbora Hermankova, Pavla Bohacova, Jan Kossl, Milada Chudickova, Michaela Hajkova, Magdalena Krulova, Alena Zajicova, Eliska Javorkova
Mesenchymal stem cells (MSCs) represent a population of cells which have the ability to regulate reactivity of T and B lymphocytes by multiple mechanisms. The immunoregulatory activities of MSCs are strictly influenced by the cytokine environment. Here we show that two functionally distinct cytokines, interleukin-4 (IL-4) and interferon-γ (IFN-γ), significantly potentiate the ability of MSCs to inhibit IL-10 production by activated regulatory B cells (Bregs). However, MSCs in the presence of IL-4 or IFN-γ inhibit the IL-10 production by different mechanisms...
December 2016: Stem Cell Reviews
https://www.readbyqxmd.com/read/27622036/tumor-released-autophagosomes-induce-il-10-producing-b-cells-with-suppressive-activity-on-t-lymphocytes-via-tlr2-myd88-nf-%C3%AE%C2%BAb-signal-pathway
#15
Meng Zhou, Zhifa Wen, Feng Cheng, Jie Ma, Weixia Li, Hongyan Ren, Yemeng Sheng, Huixia Dong, Liwei Lu, Hong-Ming Hu, Li-Xin Wang
Recent studies have shown that tumor cells can release autophagosomes, which transport a broad array of biologically active molecules with potential modulatory effects on immune cell functions. In this study, we aimed to investigate the role of tumor cells-released autophagosomes (i.e. TRAP) in regulating B cell differentiation and function. TRAPs from murine tumor cell lines were found to induce splenic B cells to differentiate into IL-10-producing regulatory B cells (Bregs) with a distinct phenotype of CD1d(+) CD5(+), which could potently inhibit CD8(+) and CD4(+) T cell responses in IL-10-depedent manner both in vitro and in vivo...
July 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27609568/-regulatory-b-cells-activated-by-cpg-odn-combined-with-anti-cd40-monoclonal-antibody-inhibit-cd4-t-cell-proliferation
#16
Keng Wang, Lei Tao, Jianbing Su, Yueyang Zhang, Binhua Zou, Yiyuan Wang, Xiaojuan Li
Objective To observe the immunosuppressive function of regulatory B cells (Bregs) in vitro after activated by CpG oligodeoxynucleotide (CpG-ODN) and anti-CD40 mAb. Methods Mice splenic CD5(+)CD1d(high)B cells and CD5(-)CD1d(low)B cells were sorted by flow cytometry. These B cells were first stimulated with CpG-ODN combined with anti-CD40 mAb for 24 hours, and then co-cultured with purified CD4(+)T cells. The interleukin 10 (IL-10) expression in the activated Bregs and other B cell subset, as well as the proliferation and interferon γ (IFN-γ) expression in the CD4(+) T cells activated by anti-CD3 mAb plus anti-CD28 mAb were determined by flow cytometry...
September 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27596706/role-of-regulatory-b-cells-in-immune-tolerance-to-allergens-and-beyond
#17
REVIEW
Willem van de Veen, Barbara Stanic, Oliver F Wirz, Kirstin Jansen, Anna Globinska, Mübeccel Akdis
Immune tolerance to both self-antigens and innocuous non-self-antigens is essential to protect the host against chronic inflammatory diseases and tissue damage. A wide range of cell types and suppressive molecules are involved in induction and maintenance of tolerance. In addition to their key function in the production of immunoglobulins, B cells can regulate immune responses through their surface molecules and secretion of cytokines. Regulatory B (Breg) cells are characterized by their immunosuppressive capacity, which is often mediated through IL-10 secretion...
September 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27534560/b-cell-responses-associated-with-vaccine-induced-delayed-sivmac251-acquisition-in-female-rhesus-macaques
#18
Venkatramanan Mohanram, Thorsten Demberg, Thomas Musich, Iskra Tuero, Diego A Vargas-Inchaustegui, Leia Miller-Novak, David Venzon, Marjorie Robert-Guroff
An established sex bias in HIV pathogenesis is linked to immune responses. Recently we reported a vaccine-induced sex bias: vaccinated female but not male rhesus macaques exhibited delayed SIV acquisition. This outcome was correlated with SIV Env-specific rectal IgA, rectal memory B cells, and total rectal plasma cells. To uncover additional contributing factors, using samples from the same study, we investigated memory B cell population dynamics in blood, bone marrow, and rectal tissue during immunization and postchallenge; IgG subtypes and Ab avidity; and regulatory B (Breg) cell frequency and function...
September 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27515534/human-umbilical-cord-derived-mesenchymal-stem-cells-protect-against-experimental-colitis-via-cd5-b-regulatory-cells
#19
Kang Chao, Shenghong Zhang, Yun Qiu, Xiaoyong Chen, Xiaoran Zhang, Chuang Cai, Yanwen Peng, Ren Mao, Meirav Pevsner-Fischer, Shomron Ben-Horin, Eran Elinav, Zhirong Zeng, Baili Chen, Yao He, Andy Peng Xiang, Minhu Chen
BACKGROUND: To clarify the effect of human umbilical cord-derived mesenchymal stem cell (hUC-MSCs) treatment on colitis and to explore the role of CD5(+) B cells in MSC therapy. METHODS: The trinitrobenzenesulfonic acid (TNBS)-induced colitis mouse model was used. HUC-MSCs were transferred peritoneally. Survival rates, colitis symptoms, and macroscopic and histologic scores were evaluated. CD4(+) T helper (Th) cell subgroups and CD5(+) regulatory B cell (Bregs) in lymphocytes were quantitated by flow cytometry...
August 11, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27439912/il-10-regulatory-b-cells-are-enriched-in-cord-blood-and-may-protect-against-cgvhd-after-cord-blood-transplantation
#20
Anushruti Sarvaria, Rafet Basar, Rohtesh S Mehta, Hila Shaim, Muharrem Muftuoglu, Ahmad Khoder, Takuye Sekine, Elif Gokdemir, Kayo Kondo, David Marin, May Daher, Amin M Alousi, Abdullah Alsuliman, Enli Liu, Betul Oran, Amanda Olson, Roy B Jones, Uday Popat, Chitra Hosing, Richard Champlin, Elizabeth J Shpall, Katayoun Rezvani
Cord blood (CB) offers a number of advantages over other sources of hematopoietic stem cells, including a lower rate of chronic graft-versus-host disease (cGVHD) in the presence of increased HLA disparity. Recent research in experimental models of autoimmunity and in patients with autoimmune or alloimmune disorders has identified a functional group of interleukin-10 (IL-10)-producing regulatory B cells (Bregs) that negatively regulate T-cell immune responses. At present, however, there is no consensus on the phenotypic signature of Bregs, and their prevalence and functional characteristics in CB remain unclear...
September 8, 2016: Blood
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