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https://www.readbyqxmd.com/read/28294065/tetramethylpyrazine-facilitates-functional-recovery-after-spinal-cord-injury-by-inhibiting-mmp2-mmp9-and-vascular-endothelial-cell-apoptosis
#1
Jian-Zhong Hu, Xiao-Kai Wang, Yong Cao, Dong-Zhe Li, Tian-Ding Wu, Tao Zhang, Da-Qi Xu, Hong-Bin Lu
BACKGROUND: Spinal cord injury (SCI) is a major public health issue that leads to neurological dysfunctions and morbidities in patients. Tetramethylpyrazine (TMP) plays a neuroprotective role in SCI; however, the underlying mechanism has not been fully elucidated. Objective In the present study, we aimed to investigate the mechanisms and therapeutic effects of TMP on SCI. METHODS: A contusion SCI model was established that used a modified Allen's method. In the TMP group, TMP (200 mg/kg) was injected daily for 5 days post-injury, while in the Negative Control (NC) group, an equal volume of normal saline was injected...
March 13, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28149752/epidermal-growth-factor-receptor-tyrosine-kinase-inhibitors-for-the-treatment-of-central-nervous-system-metastases-from-non-small-cell-lung-cancer-the-present-and-the-future
#2
REVIEW
Claudia Proto, Martina Imbimbo, Rosaria Gallucci, Angela Brissa, Diego Signorelli, Milena Vitali, Marianna Macerelli, Giulia Corrao, Monica Ganzinelli, Francesca Gabriella Greco, Marina Chiara Garassino, Giuseppe Lo Russo
Lung cancer is one of the major causes of cancer related mortality worldwide. Brain metastases (BM) complicate clinical evolution of non-small cell lung cancer (NSCLC) in approximately 25-40% of cases, adversely influencing quality of life (QoL) and overall survival (OS). Systemic therapy remains the standard strategy for metastatic disease. Nevertheless, the blood-brain barrier (BBB) makes central nervous system (CNS) a sanctuary site. To date, the combination of chemotherapy with whole brain radiation therapy (WBRT), surgery and/or stereotactic radiosurgery (SRS) represents the most used treatment for patients (pts) with intracranial involvement...
December 2016: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28088075/development-of-a-hypoxia-triggered-and-hypoxic-radiosensitized-liposome-as-a-doxorubicin-carrier-to-promote-synergetic-chemo-radio-therapy-for-glioma
#3
Hongmei Liu, Yandong Xie, Yafei Zhang, Yifan Cai, Baiyang Li, Honglin Mao, Yingguo Liu, Jun Lu, Longzhen Zhang, Rutong Yu
The treatment of malignant primary brain tumors is challenging. Concomitant radiochemotherapy has become the standard clinical treatment for malignant glioma, but there are two critical challenges to overcome in order to increase efficacy. First, glioma is known to have increased resistant to radiation due to its intra-tumoral hypoxia. In addition, the blood-brain barrier (BBB) restricts the distribution of the chemotherapeutic agent to the brain. Therefore, we developed a hypoxic radiosensitizer-prodrug liposome (MLP), in order to deliver DOX to the tumor and to overcome the above challenges, achieving a synergistic chemo-/radiotherapy treatment of malignant glioma...
March 2017: Biomaterials
https://www.readbyqxmd.com/read/27861324/laser-ablation-of-recurrent-malignant-gliomas-current-status-and-future-perspective
#4
Analiz Rodriguez, Stephen B Tatter
Recurrent malignant glioma continues to be a clinical challenge, and repeat surgery is an option in only select patients. Stereotactic laser ablation, a new minimally invasive technique, can be used as an alternative to surgery. We review the current literature on laser ablation for recurrent malignant gliomas as well as discuss practical and theoretical advantages and disadvantages of this emerging technique in comparison with repeat surgery or radiation. We also discuss the potential for laser ablation to augment adjuvant therapies, namely, chemotherapy, radiation, and immunotherapy...
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27861323/stereotactic-laser-interstitial-thermal-therapy-for-recurrent-high-grade-gliomas
#5
Ian Lee, Steven Kalkanis, Constantinos G Hadjipanayis
BACKGROUND: The value of maximal safe cytoreductive surgery in recurrent high-grade gliomas (HGGs) is gaining wider acceptance. However, patients may harbor recurrent tumors that may be difficult to access with open surgery. Laser interstitial thermal therapy (LITT) is emerging as a technique for treating a variety of brain pathologies, including primary and metastatic tumors, radiation necrosis, and epilepsy. OBJECTIVE: To review the role of LITT in the treatment of recurrent HGGs, for which current treatments have limited efficacy, and to discuss the possible role of LITT in the disruption of the blood-brain barrier to increase delivery of chemotherapy locoregionally...
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27808492/dual-targeting-magnetic-plga-nanoparticles-for-codelivery-of-paclitaxel-and-curcumin-for-brain-tumor-therapy
#6
Yanna Cui, Meng Zhang, Feng Zeng, Hongyue Jin, Qin Xu, Yongzhuo Huang
Chemotherapy is one of the most important strategies for glioma treatment. However, the "impermeability" of the blood-brain barrier (BBB) impedes most chemotherapeutics from entering the brain, thereby rendering very few drugs suitable for glioma therapy, letting alone application of a combination of chemotherapeutics. Thereby, there is a pressing need to overcome the obstacles. A dual-targeting strategy was developed by a combination of magnetic guidance and transferrin receptor-binding peptide T7-mediated active targeting delivery...
November 30, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27738326/radiosensitizing-effect-of-lapatinib-in-human-epidermal-growth-factor-receptor-2-positive-breast-cancer-cells
#7
Tosol Yu, Bong Jun Cho, Eun Jung Choi, Ji Min Park, Dan Hyo Kim, In Ah Kim
Trastuzumab has been widely used for the treatment of human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer, however, it cannot easily cross the blood-brain barrier (BBB) and is known to increase the incidence of brain metastases. In contrast, lapatinib has a low molecular weight and can cross the BBB and it could be useful to treat brain metastases in patients with HER2-positive breast cancer.To explore the impact of lapatinib on radiation response, we conducted an in vitro experiment using SKBR3 and BT474 breast carcinoma cells exhibiting HER2/neu amplification...
October 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27538905/intracranial-applications-of-mr-imaging-guided-focused-ultrasound
#8
REVIEW
N Khanna, D Gandhi, A Steven, V Frenkel, E R Melhem
Initially used in the treatment of prostate cancer and uterine fibroids, the role of focused ultrasound has expanded as transcranial acoustic wave distortion and other limitations have been overcome. Its utility relies on focal energy deposition via acoustic wave propagation. The duty cycle and intensity of focused ultrasound influence the rate of energy deposition and result in unique physiologic and biomechanical effects. Thermal ablation via high-intensity continuous exposure generates coagulative necrosis of tissues...
August 18, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27469219/delivery-of-nanoparticles-for-treatment-of-brain-tumor
#9
REVIEW
Chen Kang, Yuan Sun, Jing Zhu, Wen Li, Aili Zhang, Tairong Kuang, Jing Xie, Zhaogang Yang
BACKGROUND: Malignant brain tumor is a highly challenging disease for diagnosis, treatment, and management. Cytotoxicity, distribution and the ability to cross blood brain barrier are some of the most significant issues for the chemotherapy of brain tumors. Nanotechnology has been widely exploited in drug delivery with great potential in improving the drug efficiency and efficacy. The advent of nanotechnology would greatly facilitate the early detection and treatment of brain tumors. This review will be primarily focused on current nano drug delivery system for brain cancer therapy...
2016: Current Drug Metabolism
https://www.readbyqxmd.com/read/27292970/harnessing-nanomedicine-for-therapeutic-intervention-in-glioblastoma
#10
Anna Gutkin, Zvi R Cohen, Dan Peer
INTRODUCTION: Glioblastoma is a type of brain cancer arises from glial cells. Glioblastoma multiforme (GBM), a subtype of glioblastoma, is the most common and most aggressive primary brain tumor. Currently, GBM therapy includes surgery and post-operative high-doses of radiation and chemotherapy. This therapeutic strategy has a limited contribution in extending the survival rate of GBM patients. AREAS COVERED: Herein, we focus on harnessing nanoscale drug delivery strategies to treat brain malignancies...
June 13, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27267840/evaluating-changes-to-blood-brain-barrier-integrity-in-brain-metastasis-over-time-and-after-radiation-treatment
#11
Donna H Murrell, Niloufar Zarghami, Michael D Jensen, Ann F Chambers, Eugene Wong, Paula J Foster
INTRODUCTION: The incidence of brain metastasis due to breast cancer is increasing, and prognosis is poor. Treatment is challenging because the blood-brain barrier (BBB) limits efficacy of systemic therapies. In this work, we develop a clinically relevant whole brain radiotherapy (WBRT) plan to investigate the impact of radiation on brain metastasis development and BBB permeability in a murine model. We hypothesize that radiotherapy will decrease tumor burden and increase tumor permeability, which could offer a mechanism to increase drug uptake in brain metastases...
June 2016: Translational Oncology
https://www.readbyqxmd.com/read/27023712/challenges-in-the-treatment-of-hormone-receptor-positive-her2-negative-metastatic-breast-cancer-with-brain-metastases
#12
REVIEW
Minetta C Liu, Javier Cortés, Joyce O'Shaughnessy
Brain metastases are a major cause of morbidity and mortality for women with hormone receptor (HR)-positive breast cancer, yet little is known about the optimal treatment of brain disease in this group of patients. Although these patients are at lower risk for brain metastases relative to those with HER2-positive and triple-negative disease, they comprise the majority of women diagnosed with breast cancer. Surgery and radiation continue to have a role in the treatment of brain metastases, but there is a dearth of effective systemic therapies due to the poor penetrability of many systemic drugs across the blood-brain barrier (BBB)...
June 2016: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/26904576/concurrent-therapy-to-enhance-radiotherapeutic-outcomes-in-glioblastoma
#13
REVIEW
Divya Khosla
Glioblastoma is one of the most fatal and incurable human cancers characterized by nuclear atypia, mitotic activity, intense microvascular proliferation and necrosis. The current standard of care includes maximal safe surgical resection followed by radiation therapy (RT) with concurrent and adjuvant temozolomide (TMZ). The prognosis remains poor with median survival of 14.6 months with RT plus TMZ. Majority will have a recurrence within 2 years from diagnosis despite adequate treatment. Radiosensitizers, radiotherapy dose escalation and altered fractionation have failed to improve outcome...
February 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/26822319/targeted-therapies-for-the-treatment-of-brain-metastases-in-solid-tumors
#14
Jan-Paul Bohn, Georg Pall, Guenther Stockhammer, Michael Steurer
Brain metastases are a major cause of morbidity and mortality in cancer patients. While the mainstay treatment comprises surgery and radiation therapy, the role of systemic agents remains controversial. In general, it has been presumed that poor blood-brain barrier (BBB) penetration and inherently more resistant metastatic brain disease preclude a favorable systemic treatment approach. However, a better understanding of tumor biology and the subsequent development of targeted drugs have reawakened interest in systemic therapy...
June 2016: Targeted Oncology
https://www.readbyqxmd.com/read/26796272/nanoparticles-novel-vehicles-in-treatment-of-glioblastoma
#15
REVIEW
Fatemeh Pourgholi, Mahsa Hajivalili, Jadidi-Niaragh Farhad, Hossein Samadi Kafil, Mehdi Yousefi
Glioblastoma multiform (GBM) is the most common brain tumor. The current GBM treatments comprise of radiation therapy, chemotherapy and surgery. One of the most important problems regarding the treatment of GBM is the presence of blood brain barrier (BBB) which inhibits the efficient drug delivery into central nervous system (CNS). Nanothechnology can help to deliver therapeutic drugs into CNS through crossing the BBB. There are different types of nanoparticles (Nps) which can be manipulated for clinical applications as a treatment for CNS-related disorders...
February 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/26745323/a-combined-approach-employing-chlorotoxin-nanovectors-and-low-dose-radiation-to-reach-infiltrating-tumor-niches-in-glioblastoma
#16
Matteo Tamborini, Erica Locatelli, Marco Rasile, Ilaria Monaco, Simona Rodighiero, Irene Corradini, Mauro Comes Franchini, Lorena Passoni, Michela Matteoli
Glioblastoma multiforme (GBM) is the most aggressive form of glioma, with life expectancy of around 2 years after diagnosis, due to recidivism and to the blood-brain barrier (BBB) limiting the amount of drugs which reach the residual malignant cells, thus contributing to the failure of chemotherapies. To bypass the obstacles imposed by the BBB, we investigated the use of nanotechnologies combined with radiotherapy, as a potential therapeutic strategy for GBM. We used poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PNP) conjugated to chlorotoxin (CTX), a peptide reported to bind selectively to glioma cells...
February 23, 2016: ACS Nano
https://www.readbyqxmd.com/read/26708643/ionizing-radiation-engineered-nanogels-as-insulin-nanocarriers-for-the-development-of-a-new-strategy-for-the-treatment-of-alzheimer-s-disease
#17
Pasquale Picone, Lorena Anna Ditta, Maria Antonietta Sabatino, Valeria Militello, Pier Luigi San Biagio, Maria Laura Di Giacinto, Laura Cristaldi, Domenico Nuzzo, Clelia Dispenza, Daniela Giacomazza, Marta Di Carlo
A growing body of evidence shows the protective role of insulin in Alzheimer's disease (AD). A nanogel system (NG) to deliver insulin to the brain, as a tool for the development of a new therapy for Alzheimer's Disease (AD), is designed and synthetized. A carboxyl-functionalized poly(N-vinyl pyrrolidone) nanogel system produced by ionizing radiation is chosen as substrate for the covalent attachment of insulin or fluorescent molecules relevant for its characterization. Biocompatibility and hemocompatibility of the naked carrier is demonstrated...
February 2016: Biomaterials
https://www.readbyqxmd.com/read/26666668/corilagin-attenuates-radiation-induced-brain-injury-in-mice
#18
Fan Tong, Jian Zhang, Li Liu, Xican Gao, Qian Cai, Chunhua Wei, Jihua Dong, Yu Hu, Gang Wu, Xiaorong Dong
Cranial irradiation-induced inflammation plays a critical role in the initiation and progression of radiation-induced brain injury (RIBI). Anti-inflammation treatment may provide therapeutic benefits. Corilagin (beta-1-O-galloyl-3, 6-(R)-hexahydroxydiphenoyl-D-glucose, C27H22O18) was a novel member of the tannin family with anti-inflammatory properties and is isolated from some medicinal plants, such as Phyllanthus amarus and Caesalpinia coriaria. In this study, the effect of Corilagin on RIBI was investigated and the underlying mechanisms were explored...
December 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26557503/dipg-in-children-what-can-we-learn-from-the-past
#19
REVIEW
Magimairajan Issai Vanan, David D Eisenstat
Brainstem tumors represent 10-15% of pediatric central nervous system tumors and diffuse intrinsic pontine glioma (DIPG) is the most common brainstem tumor of childhood. DIPG is almost uniformly fatal and is the leading cause of brain tumor-related death in children. To date, radiation therapy (RT) is the only form of treatment that offers a transient benefit in DIPG. Chemotherapeutic strategies including multi-agent neoadjuvant chemotherapy, concurrent chemotherapy with RT, and adjuvant chemotherapy have not provided any survival advantage...
2015: Frontiers in Oncology
https://www.readbyqxmd.com/read/26529530/-blood-brain-barrier-permeability-in-healthy-rats-and-rats-with-experimental-c6-glioma-after-fractionated-radiotherapy-of-the-brain
#20
G M Yusubalieva, A B Levinskiy, Ya A Zorkina, V P Baklaushev, S A Goryaynov, G V Pavlova, P A Mel'nikov, G E Gorlachev, A V Golanov, A A Potapov, V P Chekhonin
OBJECTIVE: To evaluate the effect of fractionated radiotherapy on permeability of the blood-brain barrier in healthy rats and rats with C6 glioma in vivo. MATERIAL AND METHODS: An increase in BBB permeability in C6 glioma was assessed by dynamic MRI monitoring (glioma size before and after radiation therapy in combination with immunotherapy, n=30) and confocal microscopy (fluorescence imaging of tumor invasion boundaries in a dose-dependent experiment for the amount of injected antibodies)...
2015: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
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