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José M Lasso, Daniel Poletti, Batolomé Scola, Pedro Gómez-Vilda, Ana I García-Martín, María Eugenia Fernández-Santos
Background: Paralysis of one vocal fold leads to glottal gap and vocal fold insufficiency that has significant impact upon a patient's quality of life. Fillers have been tested to perform intracordal injections, but they do not provide perdurable results. Early data suggest that enriching fat grafts with adipose-derived regenerative cells (ADRCs) promote angiogenesis and modulate the immune response, improving graft survival. The aim of this study is to propose ADRC-enriched adipose tissue grafts as effective filler for the paralyzed vocal fold to use it for functional reconstruction of the glottal gap...
2018: Stem Cells International
Miriam Saiz-Rodríguez, Daniel Romero-Palacián, Carlos Villalobos-Vilda, José Luis Caniego, Carmen Belmonte, Dora Koller, Eduardo Bárcena, María Talegón, Francisco Abad-Santos
This observational retrospective study assessed antiplatelet response and clinical events after clopidogrel treatment in patients who underwent percutaneous neurointervention, related to CYP2C19 metabolizer status (normal (NM), intermediate/poor (IM-PM) and ultra-rapid (UM); inferred from *2, *3 and *17 allele determination). From 123 patients, IM-PM had higher aggregation value (201.1 vs 137.6 NM, 149.4 UM, p<0.05) and lower response rate (37.5% vs. 69.8% NM, 61.1% UM), along with higher treatment change rate (25% vs...
March 14, 2018: Clinical Pharmacology and Therapeutics
Amir M Abdelhamid, Rania Ramadan Abdelaziz, Hatem A Salem
Type I diabetes (TID) is generally assumed to be caused by an immune associated, if not directly immune-mediated, destruction of pancreatic β-cells. In patients with long-term diabetes, the pancreas lacks insulin-producing cells and the residual β-cells are unable to regenerate. Patients with TID are subjected to a lifelong insulin therapy which shows risks of hypoglycemia, suboptimal control and ketosis. In this study, we investigated the potential role of Vildagliptin (Vilda) alone or in combination with Pioglitazone (Pio), as treatment regimens for TID using Streptozotocin (STZ) induced TID model in rats...
March 6, 2018: Canadian Journal of Physiology and Pharmacology
Naoyuki Kitao, Hideaki Miyoshi, Tomoo Furumoto, Kota Ono, Hiroshi Nomoto, Aika Miya, Chiho Yamamoto, Atsushi Inoue, Kenichi Tsuchida, Naoki Manda, Yoshio Kurihara, Shin Aoki, Akinobu Nakamura, Tatsuya Atsumi
BACKGROUND: Dipeptidyl peptidase-4 (DPP-4) inhibitors may have protective effects in the early stage of atherosclerosis in patients with type 2 diabetes, although similar effects in advanced atherosclerosis were not shown in recent randomized placebo-controlled studies. Therefore, we investigated the efficacy of DPP-4 inhibitor on endothelial function and glycemic metabolism compared with high-dose metformin. METHODS: In this multicenter, open-labeled, prospective, randomized, parallel-group comparison study, patients with type 2 diabetes treated with low-dose metformin (500-750 mg/day) were enrolled and randomly assigned to a vildagliptin, a DPP-4 inhibitor, add-on group (Vilda) or a double dose of metformin group (high Met) for 12 weeks...
October 10, 2017: Cardiovascular Diabetology
Pedro Gómez-Vilda, Jiri Mekyska, José M Ferrández, Daniel Palacios-Alonso, Andrés Gómez-Rodellar, Victoria Rodellar-Biarge, Zoltan Galaz, Zdenek Smekal, Ilona Eliasova, Milena Kostalova, Irena Rektorova
Aim: The research described is intended to give a description of articulation dynamics as a correlate of the kinematic behavior of the jaw-tongue biomechanical system, encoded as a probability distribution of an absolute joint velocity. This distribution may be used in detecting and grading speech from patients affected by neurodegenerative illnesses, as Parkinson Disease. Hypothesis: The work hypothesis is that the probability density function of the absolute joint velocity includes information on the stability of phonation when applied to sustained vowels, as well as on fluency if applied to connected speech...
2017: Frontiers in Neuroinformatics
Goltaj Bayrami, Pouran Karimi, Fariba Agha-Hosseini, Saeid Feyzizadeh, Reza Badalzadeh
BACKGROUND: Cardioprotective actions of ischemic postconditioning (IPostC) against ischemia/reperfusion (I/R) injury are abolished in diabetic hearts. This study has investigated the combined effects of IPostC and vildagliptin (Vilda) on myocardial function and infarct size (IS) against I/R injury in diabetic myocardium. METHODS: Diabetes was induced by a high-fat diet/low dose of streptozotocin (35 mg/kg; intraperitoneally) in Wistar rats (200-250 g) and lasted for 12 weeks...
March 2018: Journal of Cardiovascular Pharmacology and Therapeutics
I Hidalgo, P Gómez Vilda, E Garayzábal
The voice of persons with Williams syndrome (WS) is described as hoarse with a deep and unstable fundamental frequency (f0). These observations may be justified by the deficit of elastin due to a haplo-insufficiency in the ELN gene characteristic of the syndrome. In view of the possible relationship between elastin deficit and dysphonia, a study of the dynamic function of WS phonation was conducted by means of biomechanical analysis. In order to assess the presence of dysphonic symptoms and their degree of severity, the biomechanical description of WS phonation has been evaluated in terms of dynamic mass and viscoelasticity estimates...
August 2, 2017: Journal of Voice: Official Journal of the Voice Foundation
Eugenia San Segundo, Athanasios Tsanas, Pedro Gómez-Vilda
There is a growing consensus that hybrid approaches are necessary for successful speaker characterization in Forensic Speaker Comparison (FSC); hence this study explores the forensic potential of voice features combining source and filter characteristics. The former relate to the action of the vocal folds while the latter reflect the geometry of the speaker's vocal tract. This set of features have been extracted from pause fillers, which are long enough for robust feature estimation while spontaneous enough to be extracted from voice samples in real forensic casework...
January 2017: Forensic Science International
Luis Miguel Mazaira-Fernandez, Agustín Álvarez-Marquina, Pedro Gómez-Vilda
Person identification, especially in critical environments, has always been a subject of great interest. However, it has gained a new dimension in a world threatened by a new kind of terrorism that uses social networks (e.g., YouTube) to broadcast its message. In this new scenario, classical identification methods (such as fingerprints or face recognition) have been forcedly replaced by alternative biometric characteristics such as voice, as sometimes this is the only feature available. The present study benefits from the advances achieved during last years in understanding and modeling voice production...
2015: Frontiers in Bioengineering and Biotechnology
Aline Fofonka, Jorge Pinto Ribeiro, Karina Rabello Casali, Beatriz D Schaan
BACKGROUND: Cardiovascular disease, endothelial dysfunction, and oxidative stress are common complications among patients with type 2 diabetes (T2DM). In addition to the average blood glucose concentration, glycemic variability may be an important factor for the development of chronic diabetes complications. Patients with T2DM are treated with various types of oral glucose-lowering drugs. Exercise is considered to benefit the health of both healthy and unhealthy individuals, which has been confirmed by a number of scientific research studies in which the participants' health improved...
November 4, 2014: Trials
Sarah J Iribarren, Fernando Rubinstein, Vilda Discacciati, Patricia F Pearce
Purpose. In Argentina, tuberculosis (TB) control measures have not achieved key treatment targets. The purpose of this study was to identify modes of treatment delivery and explore patient and healthcare personnel perceptions of barriers and facilitators to treatment success. Methods. We used semistructured group and individual interviews for this descriptive qualitative study. Eight high burden municipalities were purposively selected. Patients in treatment for active TB (n = 16), multidisciplinary TB team members (n = 26), and TB program directors (n = 12) at local, municipal, regional, and national levels were interviewed...
2014: Tuberculosis Research and Treatment
Dominique Simon, Bruno Detournay, Evelyne Eschwege, Stephane Bouée, Jacques Bringer, Claude Attali, Sylvie Dejager
INTRODUCTION: There is an increasing interest for real-life data on drug use in many countries. Reimbursement authorities more and more request observational studies to assess the conditions of use of the products but also to improve knowledge about efficacy and safety in the real world and on a longer term than in clinical trials. AIM: To evaluate the effectiveness, treatment persistence and tolerability of vildagliptin in clinical practice. METHODS: This observational, 2-year prospective cohort study was conducted in France on request of the Health Authorities [Haute Autorite de Sante (HAS)]...
June 2014: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Daniel A Tatosian, Ying Guo, Andrea K Schaeffer, Natalia Gaibu, Serghei Popa, Aubrey Stoch, Ronald B Langdon, Eunkyung A Kauh
INTRODUCTION: Saxagliptin, sitagliptin, and vildagliptin are dipeptidyl peptidase-4 (DPP-4) inhibitors widely approved for use in patients with type 2 diabetes. Using a crossover design, the present study compared trough levels of DPP-4 inhibition provided by these agents in a single cohort of patients with type 2 diabetes. METHODS: This was a randomized, placebo-controlled, open-label, five-period crossover study. Eligible patients were 18-65 years of age, either treatment-naïve or off prior antihyperglycemic agent therapy for at least 6 or 12 weeks (depending on the prior therapy), and had glycated hemoglobin (HbA1C) ≥6...
December 2013: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
M A Banerji, D Purkayastha, B H Francis
OBJECTIVE: This retrospective analysis assessed safety and tolerability of vildagliptin (Vilda) as an add-on to metformin in type 2 diabetes mellitus (T2DM) patients with normal renal function (GFR >80mL/min/1.73m(2)) and mild renal impairment (GFR: >50 to ≤80mL/min/1.73m(2)). METHODS: Adverse events (AE) from this 12-week, randomized, open-label study comparing Vilda 100mg and thiazolidinediones (TZD) as an add-on therapy in patients with T2DM inadequately controlled (HbA(1c): 7-10%) on a stable dose of metformin (≥1000mg/day) were analyzed...
November 2010: Diabetes Research and Clinical Practice
Juan Ignacio Godino-Llorente, Pedro Gómez-Vilda, Fernando Cruz-Roldán, Manuel Blanco-Velasco, Rubén Fraile
A new index is introduced in this article to measure the degree of normality in the speech. The proposed parameter has demonstrated to be correlated with the perceived hoarseness, giving an indication of the degree of normality. The calculation of such a parameter is based on a statistical model developed to represent normal and pathological voices. The modeling is built around Gaussian mixture models and Mel frequency cepstral coefficients. The proposed index has been named pathological likelihood index (PLI)...
November 2010: Journal of Voice: Official Journal of the Voice Foundation
Juan Ignacio Godino-Llorente, Víctor Osma-Ruiz, Nicolás Sáenz-Lechón, Pedro Gómez-Vilda, Manuel Blanco-Velasco, Fernando Cruz-Roldán
This paper evaluates the capabilities of the Glottal to Noise Excitation Ratio for the screening of voice disorders. A lot of effort has been made using this parameter to evaluate voice quality, but there do not exist any studies that evaluate the discrimination capabilities of this acoustic parameter to classify between normal and pathological voices, and neither are there any previous studies that reflect the normative values that could be used for screening purposes. A set of 226 speakers (53 normal and 173 pathological) taken from a voice disorders database were used to evaluate the usefulness of this parameter for discriminating normal and pathological voices...
January 2010: Journal of Voice: Official Journal of the Voice Foundation
R Schachtner, D Lutter, P Knollmüller, A M Tomé, F J Theis, G Schmitz, M Stetter, P Gómez Vilda, E W Lang
MOTIVATION: Modern machine learning methods based on matrix decomposition techniques, like independent component analysis (ICA) or non-negative matrix factorization (NMF), provide new and efficient analysis tools which are currently explored to analyze gene expression profiles. These exploratory feature extraction techniques yield expression modes (ICA) or metagenes (NMF). These extracted features are considered indicative of underlying regulatory processes. They can as well be applied to the classification of gene expression datasets by grouping samples into different categories for diagnostic purposes or group genes into functional categories for further investigation of related metabolic pathways and regulatory networks...
August 1, 2008: Bioinformatics
R Schachtner, D Lutter, K Stadlthanner, E W Lang, G Schmitz, A M Tomé, P Gómez Vilda
Support vector machines are applied to extract marker genes from various microarray data sets: Breast Cancer, Leukemia and Monocyte - Macrophage Differentiation to ease classification of related pathologies or characterize related gene regulation pathways.
2007: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
R Schachtner, D Lutter, F J Theis Theis, E W Lang, G Schmitz, A M Tomé, P Gómez Vilda
In this study we focus on classification tasks and apply matrix factorization techniques like principal component analysis (PCA), independent component analysis (ICA) and non-negative matrix factorization (NMF) to a microarray data set. The latter monitors the gene expression levels (GEL) of mononcytes and macrophages during and after differentiation. We show that these tools are able to identify relevant signatures in the deduced matrices and extract marker genes from these gene expression profiles (GEPs) without the need for extensive data bank search for appropriate functional annotations...
2007: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Adolfo Rubinstein, María Belizán, Vilda Discacciati
OBJECTIVES: After 4 years of deepening recession, Argentina's economy plummeted after default in 2002. This crisis critically affected health expenditures and triggered acute rationing. Our objective was to explore health decision-makers' knowledge and attitudes about economic evaluations (EE) and whether health technology assessment (HTA) were increasingly used for decision making. METHODS: A qualitative design based on semistructured interviews and focus groups was used to explore how decision makers belonging to different health sectors implement resource allocation decisions...
2007: International Journal of Technology Assessment in Health Care
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