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https://www.readbyqxmd.com/read/27861387/open-arterial-reconstruction-of-multiple-hepatic-artery-aneurysms-in-a-patient-with-hereditary-hemorrhagic-telangiectasia-a-case-report
#1
Hirotsugu Ozawa, Takao Ohki, Yuji Kanaoka, Koji Maeda, Shin Hagiwara
BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is characterized by mucocutaneous telangiectasia and visceral vascular malformations (VMs). Liver involvement with VMs may lead to high-output cardiac failure, portal hypertension, and biliary disease. There is no curative treatment for the disease, and liver transplantation is indicated for life-threatening complications. Herein, we report a case of multiple hepatic artery aneurysms (HAAs) in a patient with HHT in which open arterial reconstruction was performed...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27845509/anti-gliadin-antibodies-in-ncgs
#2
Maria Infantino, Francesca Meacci, Valentina Grossi, Donatella Macchia, Mariangela Manfredi
Although no biomarker has been identified to date, previous studies have reported that about 50% of patients with suspected Non Celiac Gluten Sensitivity (NCGS) had positive first generation anti- gliadin antibodies (AGAs), expecially of the IgG class. These antibodies are not specific for NCGS, being also found in CD (80-90%), autoimmune liver disorders (21.5%), connective tissue disease (9%) and IBS (20%), as well as in healthy controls (2-8%), but their finding in patients with a clinical phenotype consistent with NCGS has been regarded as an element supporting this diagnosis...
November 15, 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/27773807/outcomes-of-pregnancies-for-women-undergoing-endoscopy-while-they-were-pregnant-a-nationwide-cohort-study
#3
Jonas F Ludvigsson, Benjamin Lebwohl, Anders Ekbom, Ravi Kiran, Peter Hr Green, Jonas Höijer, Olof Stephansson
BACKGROUND & AIMS: Endoscopy is an integral part of the investigation and management of gastrointestinal disease. We aimed to examine outcomes of pregnancies for women who underwent endoscopy during their pregnancy. METHODS: We performed a nationwide population-based cohort study, linking data from the Swedish Medical Birth Registry (for births from 1992 through 2011) with those from the Swedish Patient Registry. We identified 3052 pregnancies exposed to endoscopy (2025 upper endoscopies, 1109 lower endoscopies, 58 endoscopic retrograde cholangiopancreatographies)...
October 20, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27755346/extra-intestinal-manifestations-of-celiac-disease-effectiveness-of-the-gluten-free-diet
#4
Hilary Jericho, Naire Sansotta, Stefano Guandalini
OBJECTIVE: To evaluate the effectiveness of the GFD on extra-intestinal symptoms in pediatric and adult celiac populations at the University of Chicago (UofC). METHODS: We conducted a retrospective chart review of the UofC Celiac Center clinic charts from January 2002 to October 2014. Demographics, serologic testing, intestinal biopsies, and extra-intestinal symptoms at presentation, 12, 24, and greater than 24 months were recorded. Extra-intestinal symptoms included: abnormal liver enzymes, arthralgia/arthritis, dermatitis herpetiformis (DH), alopecia, fatigue, headache, anemia, stomatitis, myalgias, psychiatric disorders, rashes, seizures, neuropathy, short stature, delayed puberty, osteoporosis and infertility...
October 13, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27753658/immunohistochemical-expression-of-antitissue-transglutaminase-2-in-tissue-injuries-an-interpretation-beyond-celiac-disease
#5
Prasenjit Das, Ramakant Rawat, Anil K Verma, Geetika Singh, Archana G Vallonthaiel, Rajni Yadav, Gaurav P S Gahlot, Amit K Dinda, Vineet Ahuja, Siddhartha Datta Gupta, Sanjay K Agarwal, Govind K Makharia
Tissue transglutaminase 2 enzyme plays a diverse role in intracellular and extracellular functioning. Aberrant expression of anti-TG2 antibody has recently been proposed for extraintestinal identification of celiac disease (CeD), but its utility is questionable. To examine whether anti-TG2 immunohistochemical (IHC) staining can be of diagnostic value in identifying extraintestinal involvement in CeD, tissue blocks of patients with IgA nephropathies (IgAN), minimal change disease, membranous glomerulonephritis, membrano-proliferative glomerulonephritis, normal kidney, intestinal biopsies from CeD, tropical sprue, nonspecific duodenitis, and inflammatory bowel disease; liver biopsies from patients with chronic hepatitis B and C, acute liver failure (ALF), and CeD-associated liver diseases were retrieved and subjected to IHC staining for anti-tissue transglutaminase 2 enzyme...
October 7, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27565547/evidence-informed-expert-recommendations-for-the-management-of-celiac-disease-in-children
#6
John Snyder, J Decker Butzner, Amy R DeFelice, Alessio Fasano, Stefano Guandalini, Edwin Liu, Kimberly P Newton
Although the need for effective long-term follow-up for patients with celiac disease (CD) has been recognized by many expert groups, published practice guidelines have not provided a clear approach for the optimal management of these patients. In an attempt to provide a thoughtful and practical approach for managing these patients, a group of experts in pediatric CD performed a critical review of the available literature in 6 categories associated with CD to develop a set of best practices by using evidence-based data and expert opinion...
September 2016: Pediatrics
https://www.readbyqxmd.com/read/27406450/celiac-disease-unmasked-by-acute-severe-iron-deficiency-anemia
#7
Marcelle G Meseeha, Maximos N Attia, Victor O Kolade
The prevalence of celiac disease (CD) appears to be increasing in the United States. However, the proportion of new CD cases with atypical presentations is also rising. We present the case of a 49-year-old woman who was diagnosed with CD in the setting of new, severe iron-deficiency anemia, 13 years into treatment of diarrhea-predominant irritable bowel syndrome associated with chronic mildly elevated liver function tests. While CD and iron deficiency anemia are common, this is a rare presentation of CD.
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27387923/high-levels-of-immunoglobulin-a-anti-tissue-transglutaminase-antibodies-at-diagnosis-are-a-predictive-factor-for-celiac-hepatitis
#8
Andreia Albuquerque, Susana Rodrigues, Guilherme Macedo
INTRODUCTION: Celiac hepatitis is characterized by the presence of liver injury in patients with celiac disease that resolves after gluten-free diet. AIM: To evaluate predictive factors of celiac hepatitis at celiac disease diagnosis. METHODS: Retrospective study including 46 adult patients with the diagnosis of celiac disease. RESULTS: Eighty-seven percent were women, with a mean age of 33 ± 11 years, 87% had a Marsh 3 and 46% (n = 21) had celiac hepatitis...
November 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27346589/prevalence-and-clinical-significance-of-iga-anti-tissue-transglutaminase-antibodies-in-patients-with-chronic-liver-disease
#9
Ajit Sood, Manbir Singh Khurana, Ramit Mahajan, Vandana Midha, Sandeep Puri, Amandeep Kaur, Nishit Gupta, Suresh Sharma
BACKGROUND AND AIMS: Celiac disease is a multi-systemic disease which can affect any organ system including liver. However, the prevalence of celiac disease and the sensitivity and specificity of anti tissue transglutaminase (anti-tTG) in diagnosing celiac disease in patients with cirrhosis of liver is not well established. METHODS: We screened a cohort of patients with chronic liver disease for an associated diagnosis of celiac disease. Anti-tTG was done in all patients and those with a high value were subjected to duodenal biopsy for histological confirmation...
June 26, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27338852/prevalence-and-associated-factors-of-abnormal-liver-values-in-children-with-celiac-disease
#10
Linnea Äärelä, Samuli Nurminen, Laura Kivelä, Heini Huhtala, Markku Mäki, Anna Viitasalo, Katri Kaukinen, Timo Lakka, Kalle Kurppa
BACKGROUND: The prevalence and factors associated with transaminasemia in celiac disease are poorly known. AIMS: To investigate these issues in paediatric celiac patients and controls. METHODS: Alanine aminotransferase (ALT) was studied in 150 children with untreated celiac disease, 161 disease controls and 500 population-based controls. The association between ALT and clinical and histological variables and the effect of a gluten-free diet were investigated in celiac patients...
September 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27277743/primary-carcinoid-tumor-of-the-liver-a-case-report
#11
Yoshiaki Miura, Hidekatsu Kuroda, Kazuhiro Kasai, Koryo Kondo, Toshimi Yoshida, Kazuyuki Suzuki, Shunichi Sato, Tomoyuki Masuda, Shu Ueda, Nobuo Sakashita, Tadashi Abe
A53-year-old woman was hospitalized with a hepatic tumor that had been detected on health-screening ultrasonography. Laboratory data showed no marked findings: HBs-Ag and HCV-Ab were negative, and levels of serum AFP, PIVKA-II, CEA, and CA 19-0 were within their normal ranges. Ultrasonogram showed a hyperechoic circle concentric with and inside of a hypoechoic mass in the right hepatic lobe. The tumor appeared isodense with the surrounding liver in unenhanced CT, but enhanced CT showed a low density mass. A celiac arteriogram revealed a hypervascular tumor...
June 2002: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27122784/endovascular-angioplasty-of-celiac-axis-obstruction-prior-to-pancreaticoduodenectomy-in-a-patient-with-pancreatic-neuroendocrine-carcinoma
#12
Hung Taoe Yi, Wen-Lieng Lee, Tsun-Jui Liu, Chih-Tai Ting, Chieh-Shou Su
UNLABELLED: In patients with celiac axis stenosis or occlusion, a pancreaticoduodenectomy procedure can increase the risk of hepato-pancreato-biliary and other organ ischemia or failure unless a complete revascularization of the celiac axis is performed prior to or simultaneous with such surgery. Celiac axis occlusion does not appear to be an uncommon finding in cases of pancreaticoduodenectomy. Preoperative abdominal angiography can play an important role in diagnosing this high risk comorbid disease, and adequate intervention can lead to a successful operation and good postoperative outcome...
March 2014: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27113513/urgent-multivisceral-transplantation-for-widespread-splanchnic-ischemia
#13
Lisa M Sharkey, Neil K Russell, Charlotte S Rutter, Stephen J Middleton, J Andrew Bradley, Neville V Jamieson, Andrew J Butler
BACKGROUND: Multivisceral transplantation (transplantation of the stomach, intestine, liver, and pancreas) is usually undertaken as a semi-elective procedure after thorough assessment in patients who have intestinal failure with cirrhosis, cirrhosis with portomesenteric venous thrombosis, or tumors such as desmoids involving the liver and mesentery. STUDY DESIGN: Data were collected prospectively from the time of referral and held in a central database. We used it to report the first cases of urgent multivisceral transplantation (MVT) in patients with widespread splanchnic ischemia (occlusion of the celiac axis and superior mesenteric artery) resulting in small bowel infarction and hepatic failure...
May 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27067043/development-of-carbon-11-labeled-acryl-amides-for-selective-pet-imaging-of-active-tissue-transglutaminase
#14
Berend van der Wildt, Micha M M Wilhelmus, Jonne Bijkerk, Lizeth Y F Haveman, Esther J M Kooijman, Robert C Schuit, John G J M Bol, Cornelis A M Jongenelen, Adriaan A Lammertsma, Benjamin Drukarch, Albert D Windhorst
INTRODUCTION: Tissue transglutaminase (TG2) is a ubiquitously expressed enzyme capable of forming metabolically and mechanically stable crosslinks between the γ-carboxamide of a glutamine acyl-acceptor substrate and the ε-amino functionality of a lysine acyl-donor substrate resulting in protein oligomers. High TG2 crosslinking activity has been implicated in the pathogenesis of various diseases including celiac disease, cancer and fibrotic and neurodegenerative diseases. Development of a PET tracer specific for active TG2 provides a novel tool to further investigate TG2 biology in vivo in disease states...
April 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27055450/beyond-pancreatic-insufficiency-and-liver-disease-in-cystic-fibrosis
#15
REVIEW
Stephanie Demeyer, Kris De Boeck, Peter Witters, Katrien Cosaert
UNLABELLED: Cystic fibrosis is a life shortening hereditary disease, primarily leading to progressive pulmonary infection and exocrine pancreatic dysfunction. Several gastrointestinal complications other than malabsorption can arise during the disease course and with the progressively increasing life span of patients with CF; new and more rare complications are being recognized. We review the literature on gastrointestinal manifestations in CF, excluding the liver and pancreas. CONCLUSION: We describe the clinical presentation and treatment of more common conditions like gastroesophageal reflux, small intestinal bacterial overgrowth, intussusception, meconium ileus, distal intestinal obstruction syndrome, and constipation, and we also discuss what is known on celiac disease, appendicitis, fibrosing colonopathy, inflammation and inflammatory bowel disease and gastrointestinal cancer...
July 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27030182/-celiac-disease-detection-rate-in-gastroenterological-patients
#16
S V Bykova, E A Sabelnikova, R B Gudkova, V N Drozdov, P L Shcherbakov, M V Kirova, S G Khomeriki, G G Varvanina, A A Belyaeva, A I Parfenov
AIM: To determine celiac disease detection rate in patients with digestive disease. SUBJECTS AND METHODS: A total of 318 gastroenterological patients admitted to be treated at the Central Research Institute of Gastroenterology in September to October 2012 were examined. The patients' age was 18 to 74 years (mean 51.5±16.4 years). Immunoglobulin A (IgA) and immunoglobulin G (IgG) anti-gliadin antibodies (AGA), IgA anti-tissue transglutaminase (anti-tTG) antibodies and IgG anti-tTG antibodies were determined...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/26973649/an-oral-salmonella-based-vaccine-inhibits-liver-metastases-by-promoting-tumor-specific-t-cell-mediated-immunity-in-celiac-and-portal-lymph-nodes-a-preclinical-study
#17
Alejandrina Vendrell, Claudia Mongini, María José Gravisaco, Andrea Canellada, Agustina Inés Tesone, Juan Carlos Goin, Claudia Inés Waldner
Primary tumor excision is one of the most widely used therapies of cancer. However, the risk of metastases development still exists following tumor resection. The liver is a common site of metastatic disease for numerous cancers. Breast cancer is one of the most frequent sources of metastases to the liver. The aim of this work was to evaluate the efficacy of the orally administered Salmonella Typhi vaccine strain CVD 915 on the development of liver metastases in a mouse model of breast cancer. To this end, one group of BALB/c mice was orogastrically immunized with CVD 915, while another received PBS as a control...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/26955284/type-i-enteropathy-associated-t-cell-lymphoma-in-the-colon-of-a-29-year-old-patient-and-a-brief-literature-review
#18
Jiu-Cong Zhang, Yong Wang, Xiu-Feng Wang, Fang-Xin Zhang
Enteropathy-associated T-cell lymphoma (EATL) is a rare gastrointestinal non-Hodgkin's lymphoma, originating from intraepithelial T-lymphocyte, which is specifically associated with celiac disease. EATL most commonly presents in the sixth and seventh decades of life. We report a unique case of type I EATL in the colon with liver metastasis, which was presented with nonspecific radiological findings and at a very young age (29 years old) compared with previously published data. We suggest that EATL should be regarded as part of differential diagnosis in any patient presenting with abdominal pain, diarrhea, weight loss, and malabsorption because delay in treatment can result in an irreversible clinical outcome...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/26948831/a-hhv-8-positive-hiv-negative-multicentric-castleman-disease-treated-with-r-ceop-chemotherapy-and-valganciclovir-combination
#19
Fatma Eda Nuhoglu Kantarci, Rafet Eren, Cihan Gündoğan, Gülben Erdem Huq, Mehmet Hilmi Doğu, Elif Suyanı
Multicentric Castleman disease (MCD) is a lymphoproliferative disorder characterized by systemic symptoms like recurrent lymphadenopathy, fever and hepatosplenomegaly. Human herpes virus 8 (HHV-8) can be associated with MCD whether the patient is infected with human immunodeficiency virus (HIV) or not. A 59-year-old male patient presented with fatigue, drowsiness and enlarged lymph nodes. Thoracic and abdominal computed tomography showed enlarged mediastinal, axillary, paracardiac, paraaortic, celiac, mesenteric, obturator and inguinal lymph nodes concomitant with enlarged liver and spleen...
July 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/26881168/trichohepatoenteric-syndrome-or-syndromic-diarrhea-report-of-three-members-in-a-family-first-report-from-iran
#20
F E Mahjoub, F Imanzadeh, S Mahdavi Izadi, A Nahali Moghaddam
Introduction. Intractable diarrhea of infancy (IDI) includes several types of early onset diarrhea; one of the rare etiologies is trichohepatoenteric (THE) syndrome, also known as syndromic diarrhea (SD) which was primarily described by Stankler et al. Hereby we report a family with several affected members which to our knowledge is the first case report from Iran. Report of Cases. A three-year-old boy referred with short stature, poor weight gain, and intermittent steatotic diarrhea to our center. He was born to healthy, relative parents (cousins)...
2016: Case Reports in Pathology
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