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infertility workup

Julia Hoefele, Markus J Kemper, Ulf Schoenermarck, Susanna Mueller, Hanns-Georg Klein, Anja Lemke
About 30% of children with nephrotic syndrome (NS) have inherited forms. Among them, mutations in Wilms tumor suppressor gene 1 (WT1) are a well characterized cause associated with steroid-resistant NS, Wilms tumor, and urogenital malformation in males. However, the role of WT1 mutations in adult-onset focal segmental glomerulosclerosis (FSGS) is unclear. We report the case of a 38-year-old female with FSGS. She had been diagnosed with streak ovaries during diagnostic workup for infertility. Mutational analysis identified the heterozygous mutation c...
October 5, 2016: Nephron
Ashok Agarwal, Shubhadeep Roychoudhury, Kimberly B Bjugstad, Chak-Lam Cho
The diagnosis of male infertility relies largely on conventional semen analysis, and its interpretation has a profound influence on subsequent management of patients. Despite poor correlation between conventional semen parameters and male fertility potential, inclusion of advanced semen quality tests to routine male infertility workup algorithms has not been widely accepted. Oxidative stress is one of the major mediators in various etiologies of male infertility; it has deleterious effects on spermatozoa, including DNA damage...
October 2016: Therapeutic Advances in Urology
Pragati Sethi, Arvind Sharma, Lajya Devi Goyal, Gurmeet Kaur
INTRODUCTION: Infertility leads to significant stress among couple and the reaction to infertility differs among males and females. AIM: To know the prevalence of psychiatric morbidity in infertile couples and compare the prevalence of various psychiatric disorders among husband and wife. MATERIALS AND METHODS: A cross-sectional study was conducted on 50 couples diagnosed with infertility from outdoor clinics. Both male and female partner of couple were interviewed for detailed history and clinical examination was done...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Jason R Lomboy, Robert M Coward
A varicocele is an abnormal dilatation and tortuosity of the veins of the spermatic cord. Although varicoceles are common in the general population and are frequently found on routine physical examinations, they represent the most common correctable cause of male factor infertility. Varicoceles are also often incidental findings on imaging studies, particularly scrotal ultrasound. Importantly, not all varicoceles should be treated equally (or at all), and basic guidelines on the evaluation and indications for treatment of adult varicoceles should be reviewed before counseling and treatment...
September 2016: Seminars in Interventional Radiology
Martin Blomberg Jensen, Jacob Gerner Lawaetz, Anna-Maria Andersson, Jørgen Holm Petersen, Loa Nordkap, Anne Kirstine Bang, Pia Ekbom, Ulla Nordström Joensen, Lisbeth Prætorius, Peter Lundstrøm, Vibeke Hartvig Boujida, Beate Lanske, Anders Juul, Niels Jørgensen
STUDY QUESTION: Are low vitamin D levels linked with semen quality and sex steroids in infertile men? SUMMARY ANSWER: Infertile men with vitamin D deficiency had lower sperm motility, total numbers of motile sperm, Inhibin B, sex-hormone-binding-globulin (SHBG) and testosterone/estradiol ratio, but higher levels of free sex steroids, than infertile men with normal vitamin D levels. WHAT IS KNOWN ALREADY: Low vitamin D levels have been associated with decreased sperm motility in healthy men, but a relationship between vitamin D and calcium with semen quality and especially sex steroids has not been sufficiently described in infertile men...
August 2016: Human Reproduction
Eugenio Ventimiglia, Paolo Capogrosso, Luca Boeri, Filippo Pederzoli, Walter Cazzaniga, Roberta Scano, Silvia Ippolito, Nicola Fossati, Massimo Alfano, Francesco Montorsi, Andrea Salonia
: Known genetic alterations play a major role in perturbing male reproductive health. We sought to retrospectively validate the European Association of Urology (EAU) guidelines for karyotype analysis (KA) in a homogenous cohort of 1168 White European men presenting for primary couple's infertility (noninterracial infertile couples only) and to develop a novel nomogram capable of predicting karyotype alterations. Overall, 742 (63.5%) patients would have deserved KA according to the EAU guidelines...
June 21, 2016: European Urology
Angela Graziano, Giuseppe Lo Monte, Ilaria Soave, Donatella Caserta, Massimo Moscarini, Roberto Marci
PURPOSE: To evaluate the efficacy, compliance, and cost effectiveness of sonohysterosalpingography (HyCoSy) compared with hysteroscopy for uterine cavity evaluation and compared with RX-hysterosalpingography (RX-HSG) for tubal patency determination. METHODS: Three hundred and eight infertile patients underwent HyCoSy, hysteroscopy, and RX-HSG. We compared sensitivity, specificity, positive and negative predictive values (PPV and NPV), discomfort level, and cost of all three procedures...
July 2013: Journal of Medical Ultrasonics
Jonathan E Handelzalts, Sigal Levy, Yoav Peled, Liat Binyamin, Arnon Wiznitzer, Gil Goldzweig, Haim Krissi
OBJECTIVE: Hysterosalpingography (HSG) is an accepted diagnostic tool for infertility workup and is considered an invasive procedure that is generally regarded as uncomfortable and painful, though research on psychological consequences is scarce and outdated. The study objective was to investigate women's experience of HSG in terms of fear, anxiety and pain, as compared to colposcopy. STUDY DESIGN: This cross sectional questionnaire study was conducted at two public women's health clinics in Israel between January 2013 and March 2014...
April 30, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Pinar H Kodaman
PURPOSE OF REVIEW: The objectives of the present review are to discuss the role of endometrial polyps in infertility and to analyze the evidence for hysteroscopic polypectomy prior to IVF. RECENT FINDINGS: Endometrial polyps are frequently found during routine workup for infertility and are known to negatively impact endometrial receptivity through various mechanisms. Overall, most studies to date point to a favorable effect of hysteroscopic polypectomy on subsequent fertility...
June 2016: Current Opinion in Obstetrics & Gynecology
Camilla W Rich, Alice D Domar
Health care professionals make the medical care of infertility patients a priority, with the goal of achieving a singleton pregnancy for each. Patients who never seek out care, who do not return for treatment after the diagnostic workup, or who drop out of treatment are rarely noticed. Yet this is the outcome for the majority of patients, and the primary reason after financial for treatment termination is the emotional aspect. Attending to the psychological needs of our patients must become a higher priority, to provide all patients true access to care...
May 2016: Fertility and Sterility
Amr A Soliman, Waleed Shaalan, Tamer Abdel-Dayem, Elsayed Elbadawy Awad, Yasser Elkassar, Dörte Lüdders, Eduard Malik, Hassan N Sallam
OBJECTIVES: To study the accuracy of four-dimensional (4D) ultrasound and power Doppler flow mapping in detecting tubal patency in women with sub-/infertility, and compare it with laparoscopy and chromopertubation. STUDY DESIGN: A prospective study. The study was performed in the outpatient clinic and infertility unit of a university hospital. The sonographic team and laparoscopic team were blinded to the results of each other. Women aged younger than 43 years seeking medical advice due to primary or secondary infertility and who planned to have a diagnostic laparoscopy performed, were recruited to the study after signing an informed consent...
December 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Eve C Feinberg
No abstract text is available yet for this article.
December 2015: Fertility and Sterility
Jed C Robinson, John N DeFranco, Courtney M P Hollowell
Malignant mesothelioma of the epididymis is a very rare tumor. We report a case of a 33-year old male with a left hydrocele that presented for evaluation of infertility. Scrotal ultrasound revealed a left extratesticular mass. Final pathology revealed malignant mesothelioma involving the epididymis, with well differentiated epithelioid morphology. Metastatic workup was negative.
October 2014: Current Urology
Monica Muratori, Sara Marchiani, Lara Tamburrino, Marta Cambi, Francesco Lotti, Ilaria Natali, Erminio Filimberti, Ivo Noci, Gianni Forti, Mario Maggi, Elisabetta Baldi
OBJECTIVE: To evaluate whether sperm DNA fragmentation (sDF), measured in brighter, dimmer, and total populations, predicts natural conception, and to evaluate the intra-individual variability of sDF. DESIGN: Prospective study. SETTING: Outpatient clinic and diagnostic laboratory. PATIENT(S): A total of 348 unselected patients and 86 proven fertile men. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): sDF was revealed with the use of terminal deoxynucleotide transferase-mediated dUTP nick-end labeling (TUNEL)/propidium iodide (PI)...
September 2015: Fertility and Sterility
Gaurav S Desai
No abstract text is available yet for this article.
May 2015: Journal of Obstetrics and Gynaecology of India
Yagil Barazani, Edmund Sabanegh
Although neither Klinefelter syndrome nor monozygotic twins are particularly rare (1/667 male births and 3-4/1000 live births, respectively), the occurrence of both in the same pregnancy (ie, identical twins with Klinefelter syndrome) is exceedingly rare and has only been reported three times previously in the literature. This report describes the fourth ever reported case of monozygotic twins with Klinefelter syndrome (who presented to our male fertility clinic with failure to conceive) and sheds interesting light on the reproductive concordance observed with this rare clinical entity...
2015: Reviews in Urology
Iya Eze Bassey, Alphonsus Ekpe Udoh, Okon Ekwerre Essien, Idongesit Kokoabasi Paul Isong, Rebecca Mtaku Gali, Edim Eyo Archibong
INTRODUCTION: Human infertility is a complex global health problem. It has multiple social consequences which are especially profound for thyroid hormones in infertility with the aim of determining the degree of association of thyroid hormones with hyperprolactinemia in our population. MATERIALS AND METHODS: The serum levels of prolactin, T3, T4 and TSH were determined in 90 hyperprolactinemic infertile women, 90 normoprolactinemic infertile women and 50 fertile women...
March 2015: Journal of Clinical and Diagnostic Research: JCDR
Ekrem M Bilgin, Ertug Kovanci
PURPOSE OF REVIEW: To provide an overview on the genetic basis of premature ovarian failure (POF) with specific attention to recently published molecular genetic studies. RECENT FINDINGS: POF is an insidious cause of female infertility. Despite enormous efforts to understand the genetic pathogenesis, we know almost nothing but Turner syndrome and Fragile X syndrome. The era of genome-wide association studies opened a new window into the understanding of the complex, polygenic nature of ovarian failure by identifying several candidate regions...
June 2015: Current Opinion in Obstetrics & Gynecology
Hélène Caillon, Thomas Fréour, Kalyane Bach-Ngohou, Agnès Colombel, Marc G Denis, Paul Barrière, Damien Masson
BACKGROUND: As being overweight can impair female spontaneous fertility or after assisted reproductive technology (ART) cycles, the aim of this study was to compare in vitro fertilization (IVF) outcome according to women's body mass index (BMI). METHODS: Retrospective study conducted from 2006 to 2009 in the IVF unit of Nantes University Hospital, France. 582 patients undergoing standard infertility workup and controlled ovarian stimulation were categorized according to BMI into two groups: group 1: normal weight (20-24...
July 2015: Obesity Research & Clinical Practice
Ashok Agarwal, Rakesh Sharma, Damayanthi Durairajanayagam, Zhihong Cui, Ahmet Ayaz, Sajal Gupta, Belinda Willard, Banu Gopalan, Edmund Sabanegh
OBJECTIVE: To compare the sperm protein profile between infertile men with unilateral varicocele and infertile men with bilateral varicocele. METHODS: This prospective study investigated 50 infertile patients with clinical varicocele (33 unilateral and 17 bilateral) seeking fertility workup between March 2012 and April 2014. Routine sperm parameters, reactive oxygen species, total antioxidant capacity, and sperm deoxyribonucleic acid fragmentation were assessed in their semen...
March 2015: Urology
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