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https://www.readbyqxmd.com/read/29785216/-staphylococcus-aureus-surface-protein-g-is-an-immunodominant-protein-and-a-possible-target-in-an-anti-biofilm-drug-development
#1
Yury Belyi, Ivan Rybolovlev, Nikita Polyakov, Alena Chernikova, Irina Tabakova, Alexandre Gintsburg
Background: Staphylococcus aureus is a Gram-positive bacterium that causes severe illnesses in the human population. The capacity of S. aureus strains to form biofilms on biotic and abiotic surfaces creates serious problems for treatment of hospital infections and has stimulated efforts to develop new means of specific protection or immunotherapy. Material and Methods: We found that rabbit serum raised against crude concentrated S. aureus liquid culture significantly decreased the development of staphylococcal biofilm in vitro ...
2018: Open Microbiology Journal
https://www.readbyqxmd.com/read/29771109/the-therapeutic-pipeline-for-pseudomonas-aeruginosa-infections
#2
Lori L Burrows
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen, designated by the World Health Organization as a critical priority for development of new therapeutics due to high levels of intrinsic and acquired antibiotic resistance. Other challenges include its versatility (it can persist in the environment and most strains are capable of causing disease in compromised hosts), robust efflux mechanisms that limit drug penetration, and the propensity to form antimicrobial-tolerant biofilms. Novel therapeutics in development to prevent or treat P...
May 17, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29764945/a-mechanism-of-unidirectional-transformation-leading-to-antibiotic-resistance-occurs-within-nasopharyngeal-pneumococcal-biofilm-consortia
#3
Santiago M Lattar, Xueqing Wu, Jennifer Brophy, Fuminori Sakai, Keith P Klugman, Jorge E Vidal
Streptococcus pneumoniae acquires genes for resistance to antibiotics such as streptomycin (Str) or trimethoprim (Tmp) by recombination via transformation of DNA released by other pneumococci and closely related species. Using naturally transformable pneumococci, including strain D39 serotype 2 (S2) and TIGR4 (S4), we studied whether pneumococcal nasopharyngeal transformation was symmetrical, asymmetrical, or unidirectional. Incubation of S2Tet and S4Str in a bioreactor simulating the human nasopharynx led to the generation of SpnTet/Str recombinants...
May 15, 2018: MBio
https://www.readbyqxmd.com/read/29752963/ses-proteins-as-possible-targets-for-vaccine-development-against-staphylococcus-epidermidis-infections
#4
Dorien Hofmans, Laleh Khodaparast, Ladan Khodaparast, Els Vanstreels, Mohammad Shahrooei, Johan Van Eldere, Lieve Van Mellaert
OBJECTIVES: The opportunistic pathogen Staphylococcus epidermidis is progressively involved in device-related infections. Since these infections involve biofilm formation, antibiotics are not effective. Conversely, a vaccine can be advantageous to prevent these infections. In view of vaccine development, predicted surface proteins were evaluated on their potential as a vaccine target. METHODS: Immunoglobulins directed against S. epidermidis surface proteins SesB, M, O, Q and R, were used to firstly affirm their surface location...
May 9, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746596/the-hyr1-protein-from-the-fungus-candida-albicans-is-a-cross-kingdom-immunotherapeutic-target-for-acinetobacter-bacterial-infection
#5
Priya Uppuluri, Lin Lin, Abdullah Alqarihi, Guanpingsheng Luo, Eman G Youssef, Sondus Alkhazraji, Nannette Y Yount, Belal A Ibrahim, Michael Anthony Bolaris, John E Edwards, Marc Swidergall, Scott G Filler, Michael R Yeaman, Ashraf S Ibrahim
Different pathogens share similar medical settings and rely on similar virulence strategies to cause infections. We have previously applied 3-D computational modeling and bioinformatics to discover novel antigens that target more than one human pathogen. Active and passive immunization with the recombinant N-terminus of Candida albicans Hyr1 (rHyr1p-N) protect mice against lethal candidemia. Here we determine that Hyr1p shares homology with cell surface proteins of the multidrug resistant Gram negative bacterium, Acinetobacter baumannii including hemagglutinin (FhaB) and outer membrane protein A (OmpA)...
May 10, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29720429/clinical-and-bacteriologic-analysis-of-nontypeable-haemophilus-influenzae-strains-isolated-from-children-with-invasive-diseases-japan-2008-2015
#6
Sachiko Naito, Noriko Takeuchi, Misako Ohkusu, Azusa Takahashi-Nakaguchi, Hiroki Takahashi, Naoko Imuta, Junichiro Nishi, Keigo Shibayama, Mayumi Matsuoka, Yuko Sasaki, Naruhiko Ishiwada
Haemophilus influenzae type b (Hib) conjugate vaccines have led to a dramatic reduction in Hib disease in young children worldwide. Nontypeable H. influenzae (NTHi) is now the major cause of invasive H. influenzae infection. We investigated the clinical characteristics of invasive NTHi diseases among children in Japan to clarify the pathogenicity of isolated NTHi strains. The mortality rate was 10.7%, mainly among children with underlying comorbidities. Biotypes II and III were the most common and most (64...
May 2, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29701437/-novelties-in-ent-2017
#7
Francis Marchal
Rhinology : balloon sinuplasty and its potential commercial links ; factors of recurrence of sinunasal polyposis ; olfactory dysfunction and biofilms. Otology : effect of music and headphones on children ; vaccination and otitis media. Pharyngo-laryngology : interest of DISE (Drug Induce Sleep Endoscopy) in case of Sleep Apnea Syndrome; adenotonsillectomy and interest of robotic surgery.Salivary glands : presence of Helicobacter pylori in buccal cavity ; pepsin testing in saliva in case of reflux ; antibacterial effect of xylitol ; interest of propolis in treating candidosis...
April 25, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29615497/novel-broadly-reactive-anticapsular-antibodies-against-carbapenem-resistant-klebsiella-pneumoniae-protect-from-infection
#8
Elizabeth Diago-Navarro, Michael P Motley, Gonzalo Ruiz-Peréz, Winnie Yu, Julianne Austin, Bruna M S Seco, Guozhi Xiao, Aniska Chikhalya, Peter H Seeberger, Bettina C Fries
Carbapenem-resistant (CR) sequence type 258 (ST258) Klebsiella pneumoniae has become an urgent health care threat, causing an increasing number of high-mortality infections. Its resistance to numerous antibiotics and threat to immunocompromised patients necessitate finding new therapies to combat these infections. Previous successes in the laboratory, as well as the conservation of capsular polysaccharide (CPS) among the members of the ST258 clone, suggest that monoclonal antibody (MAb) therapy targeting the outer polysaccharide capsule of K...
April 3, 2018: MBio
https://www.readbyqxmd.com/read/29575852/streptococcus-suis-a-re-emerging-pathogen-associated-with-occupational-exposure-to-pigs-or-pork-products-part-ii-pathogenesis
#9
REVIEW
Jacek Dutkiewicz, Violetta Zając, Jacek Sroka, Bernard Wasiński, Ewa Cisak, Anna Sawczyn, Anna Kloc, Angelina Wójcik-Fatla
<i>Streptococcus suis</i> is a re-emerging zoonotic pathogen that may cause severe disease, mostly meningitis, in pigs and in humans having occupational contact with pigs and pork, such as farmers, slaughterhose workers and butchers. The first stage of the pathogenic process, similar in pigs and humans, is adherence to and colonisation of mucosal and/or epithelial surface(s) of the host. The second stage is invasion into deeper tissue and extracellular translocation of bacterium in the bloodstream, either free in circulation or attached to the surface of monocytes...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29556225/differential-immunoreactivity-to-bovine-convalescent-serum-between-mycoplasma-bovis-biofilms-and-planktonic-cells-revealed-by-comparative-immunoproteomic-analysis
#10
Shengli Chen, Huafang Hao, Ping Zhao, Wenheng Ji, Mingxia Li, Yongsheng Liu, Yuefeng Chu
Mycoplasma bovis is a major bovine pathogen that causes considerable economic losses in the cattle industry worldwide. Moreover, M. bovis biofilm can persist in the environment and its host. To date, M. bovis biofilm antigens recognized by bovine convalescent sera and their comparison with planktonic cells have not yet been explored. This study utilized an immunoproteomic approach using two-dimensional electrophoresis, immunoblotting using convalescent bovine serum, and subsequent matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry (MALDI-TOF/TOF MS) to identify the immunoreactive proteins expressed in biofilm- and planktonic-grown M...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29550192/immune-response-elicited-by-two-rbcg-strains-devoid-of-genes-involved-in-c-di-gmp-metabolism-affect-protection-versus-challenge-with-m-tuberculosis-strains-of-different-virulence
#11
Cristian Alfredo Segura-Cerda, Michel de Jesús Aceves-Sánchez, Brenda Marquina-Castillo, Dulce Mata-Espinoza, Jorge Barrios-Payán, Perla Jazmín Vega-Domínguez, César Pedroza-Roldán, Jorge Bravo-Madrigal, Alba Adriana Vallejo-Cardona, Rogelio Hernández-Pando, Mario Alberto Flores-Valdez
Pellicles, a type of biofilm, have gathered a renewed interest in the field of tuberculosis as a structure that mimics some characteristics occurring during M. tuberculosis infection, such as antibiotic recalcitrance and chronicity of infection, and as a source of antigens for humoral response in infected guinea pigs. In other bacteria, it has been well documented that the second messenger c-di-GMP modulates the transition from planktonic cells to biofilm formation. In this work, we used the live vaccine Mycobacterium bovis BCG to determine whether deletion of genes involved in c-di-GMP metabolism would affect interaction with macrophages, capacity to induce immune response in a murine cell line and mice, and how the protein profile was modified when grown as surface pellicles...
April 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29524546/an-in-silico-structural-and-physicochemical-characterization-of-tonb-dependent-copper-receptor-in-a-baumannii
#12
Sajad Abdollahi, Iraj Rasooli, Seyed Latif Mousavi Gargari
Acinetobacter baumannii is an opportunistic multidrug resistant pathogen. TonB-dependent copper receptor is an outer membrane protein and has a role in binding of A. baumannii to host cell via attachment to fibronectin. Moreover, it is highly expressed in biofilm community. In this study the properties of copper receptor were analyzed in silico and its vaccine potential was investigated. TonB-dependent copper and iron receptor domains plus one plug domain at N-terminal were determined by domain analysis. Topology modeling showed 22 β-strands, 11 loops and 10 periplasmic turns...
March 7, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29520354/group-b-streptococcal-maternal-colonization-and-neonatal-disease-molecular-mechanisms-and-preventative-approaches
#13
REVIEW
Kathryn A Patras, Victor Nizet
Group B Streptococcus (GBS) colonizes the gastrointestinal and vaginal epithelium of a significant percentage of healthy women, with potential for ascending intrauterine infection or transmission during parturition, creating a risk of serious disease in the vulnerable newborn. This review highlights new insights on the bacterial virulence determinants, host immune responses, and microbiome interactions that underpin GBS vaginal colonization, the proximal step in newborn infectious disease pathogenesis. From the pathogen perspective, the function GBS adhesins and biofilms, β-hemolysin/cytolysin toxin, immune resistance factors, sialic acid mimicry, and two-component transcriptional regulatory systems are reviewed...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29483163/a-self-assembling-whole-cell-vaccine-antigen-presentation-platform
#14
Julie Liao, Daniel R Smith, Jóhanna Brynjarsdóttir, Paula I Watnick
Diarrhea is the most common infection in children under the age of five worldwide. In spite of this, only a few vaccines to treat infectious diarrhea exist, and many of the available vaccines are sparingly and sporadically administered. Major obstacles to the development and widespread implementation of vaccination include the ease and cost of production, distribution, and delivery. Here we present a novel, customizable and self-assembling vaccine platform that exploits the Vibrio cholerae bacterial biofilm matrix for antigen presentation...
February 26, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29427720/construction-of-a-vibrio-alginolyticus-hoppmaj-hop-mutant-and-evaluation-of-its-potential-as-a-live-attenuated-vaccine-in-orange-spotted-grouper-epinephelus-coioides
#15
Huanying Pang, Mingsheng Qiu, Jingmin Zhao, Rowena Hoare, Sean J Monaghan, Dawei Song, Yunsheng Chang, Jichang Jian
Vibrio alginolyticus, a bacterial pathogen in fish and humans, expresses a type III secretion system (T3SS) that is critical for pathogen virulence and disease development. However, little is known about the associated effectors (T3SEs) and their physiological role. In this study, the T3SE gene hopPmaJ (hop) was cloned from V. alginolyticus wild-type strain HY9901 and the mutant strain HY9901Δhop was constructed by the in-frame deletion method. The results showed that the deduced amino acid sequence of V. alginolyticus HopPmaJ shared 78-98% homology with other Vibrio spp...
May 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29422887/therapeutic-targeting-of-the-staphylococcus-aureus-accessory-gene-regulator-agr-system
#16
REVIEW
Li Tan, Si Rui Li, Bei Jiang, Xiao Mei Hu, Shu Li
Staphylococcus aureus can cause numerous different diseases, which has been attributed to its large repertoire of virulence factors, many of which are under the control of the accessory gene regulator ( agr ) quorum sensing system. Under conditions of high cell density, agr increases the production of many virulence factors, decreases expression of several colonization factors, and is intimately associated with the pathogenesis and biofilm formation of S. aureus . This review summarizes our current understanding of the molecular mechanisms underlying agr quorum sensing and the regulation of agr expression...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29415569/the-adhesins-of-non-typeable-haemophilus-influenzae
#17
Karen L Osman, Johanna M Jefferies, Christopher H Woelk, David W Cleary, Stuart C Clarke
Nontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen of the respiratory tract and the greatest contributor to invasive Haemophilus disease. Additionally, in children, NTHi is responsible for the majority of otitis media (OM) which can lead to chronic infection and hearing loss. In adults, NTHi infection in the lungs is responsible for the onset of acute exacerbations in chronic obstructive pulmonary disease (COPD). Unfortunately, there is currently no vaccine available to protect against NTHi infections...
March 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29398252/from-the-genome-sequence-via-the-proteome-to-cell-physiology-pathoproteomics-and-pathophysiology-of-staphylococcus-aureus
#18
REVIEW
Michael Hecker, Ulrike Mäder, Uwe Völker
While the genome sequence is the blueprint of life, functional genomics is required to transfer the genome sequence to cell physiology. Among the Omics technologies, proteomics holds a privileged position because it deals with the main players of life, the proteins. For the model organism Staphylococcus aureus comprehensive coverage of the proteome was accomplished and used to address physiological and pathophysiological questions. This review article demonstrates that the proteomic view of physiology and pathophysiology of S...
January 5, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29372814/bacillus-velezensis-cc09-a-potential-vaccine-for-controlling-wheat-diseases
#19
Xingxing Kang, Wanling Zhang, Xunchao Cai, Tong Zhu, Yarong Xue, Changhong Liu
Biocontrol bacteria that can act like a "vaccine", stimulating plant resistance to pathogenic diseases, are still not fully elucidated. In this study, an endophytic bacterium, Bacillus velezensis CC09, labeled with green fluorescent protein, was tested for its colonization, migration, and expression of genes encoding iturin A synthetase within wheat tissues and organs as well as for protective effects against wheat take-all and spot blotch diseases. The results showed that strain CC09 not only formed biofilm on the root surface but was also widely distributed in almost every tissue, including the epidermis, cortex, and xylem vessels, and even migrated to stems and leaves, resulting in 66...
April 11, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29352409/recent-perspectives-on-the-molecular-basis-of-biofilm-formation-by-pseudomonas-aeruginosa-and-approaches-for-treatment-and-biofilm-dispersal
#20
REVIEW
Sinosh Skariyachan, Vaishnavi Sneha Sridhar, Swathi Packirisamy, Supreetha Toplar Kumargowda, Sneha Basavaraj Challapilli
Pseudomonas aeruginosa, a Gram-negative, rod-shaped bacterium causes widespread diseases in humans. This bacterium is frequently related to nosocomial infections such as pneumonia, urinary tract infections (UTIs) and bacteriaemia especially in immunocompromised patients. The current review focuses on the recent perspectives on biofilms formation by these bacteria. Biofilms are communities of microorganisms in which cells stick to each other and often adhere to a surface. These adherent cells are usually embedded within a self-produced matrix of extracellular polymeric substance (EPS)...
January 19, 2018: Folia Microbiologica
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