Liqiang Wang, Lianghong Liu, Chunyan Zhang, Guangying Yu, Wenjing Lin, Xuemin Duan, Yanshi Xiong, Guijuan Jiang, Jintao Wang, Xiangwen Liao
Infections caused by Staphylococcus aureus (S. aureus) are increasing difficult to treat because this pathogen is easily resistant to antibiotics. However, the development of novel antibacterial agents with high antimicrobial activity and low frequency of resistance remains a huge challenge. Here, building on the coupling strategy, an adamantane moiety was linked to the membrane-active Ru-based structure and then developed three novel metalloantibiotics: [Ru(bpy)2 (L)](PF6 )2 (Ru1) (bpy = 2,2-bipyridine, L = amantadine modified ligand), [Ru(dmb)2 (L)](PF6 )2 (Ru2) (dmb = 4,4'-dimethyl-2,2'-bipyridine) and [Ru(dpa)2 (L)](PF6 )2 (Ru3), (dpa = 2,2'-dipyridylamine)...
April 2, 2024: European Journal of Medicinal Chemistry