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antibiotic resistance and biofilm formation

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https://www.readbyqxmd.com/read/29231891/bioactive-compounds-produced-by-hypoxylon-fragiforme-against-staphylococcus-aureus-biofilms
#1
Kamila Tomoko Yuyama, Clara Chepkirui, Lucile Wendt, Diana Fortkamp, Marc Stadler, Wolf-Rainer Abraham
Treating infections organized in biofilms is a challenge due to the resistance of the pathogens against antibiotics and host immune cells. Many fungi grow in a wet environment, favorable for the growth of bacterial biofilms, and we speculated that fungi possess some strategies to control these bacterial biofilms. A fungus identified as Hypoxylon fragiforme, was collected in the Harz Mountains, Germany, and its mycelial culture was fermented in different culture media for 67 days to test its biological potential against bacterial biofilms...
December 12, 2017: Microorganisms
https://www.readbyqxmd.com/read/29227933/synthesis-biological-evaluation-and-metabolic-stability-of-phenazine-derivatives-as-antibacterial-agents
#2
Maddeboina Krishnaiah, Nathalia Rodrigues de Almeida, Venkatareddy Udumula, Zhongcheng Song, Yashpal Singh Chhonker, Mai M Abdelmoaty, Valter Aragao do Nascimento, Daryl J Murry, Martin Conda-Sheridan
Drug-resistant pathogens are a major cause of hospital- and community-associated bacterial infections in the United States and around the world. These infections are increasingly difficult to treat due to the development of antibiotic resistance and the formation of bacterial biofilms. In the paper, a series of phenazines were synthesized and evaluated for their in vitro antimicrobial activity against Gram positive (methicillin resistant staphylococcus aureus, MRSA) and Gram negative (Escherichia coli, E. coli) bacteria...
November 9, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29225430/insights-from-the-molecular-dynamics-simulation-of-bcsd-subunit-from-k-xylinus
#3
Simranjit Kaur, Mahesh Kulharia
Biofilms are bacteria living in micro-colonies with a protective coating in sessile form. The biofilm protects bacteria from harsh surroundings as well as help in antibiotics resistance using a semi-fluid substance. Cellulose is the major component of biofilm, which provides the sticky appearance to bacteria for attaching to the substratum. The bacteria communicate in biofilm with the help of quorum sensing hormones Acylated Homoserine Lactones (AHL's). In Komagataeibacter xylinus the four genes Bcs A, Bcs B, Bcs C, Bcs D are associated with cellulose biosynthesis...
2017: Bioinformation
https://www.readbyqxmd.com/read/29223450/pesticide-degrading-natural-multidrug-resistance-bacterial-flora
#4
REVIEW
Kirubakaran Rangasamy, Murugan Athiappan, Natarajan Devarajan, Gopinath Samykannu, Javid A Parray, K N Aruljothi, Nowsheen Shameem, Abdulaziz A Alqarawi, Abeer Hashem, Elsayed Fathi Abd Allah
Multidrug-resistant (MDR) bacteria are a growing threat to humans across the world. Antibiotic resistance is a global problem that has developed through continuous antibiotic use, combinatorial antibiotic use, pesticide-antibiotic cross-resistance, and horizontal gene transfer, as well as various other modes. Pesticide-antibiotic cross-resistance and the subsequent expansion of drug-resistant bacteria are critically documented in this review, the primary focus of which is to assess the impact of indiscriminate pesticide use on the development of microbial communities with parallel pesticide and multidrug resistance...
December 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29214000/role-of-antigen-43-on-biofilm-formation-and-horizontal-antibiotic-resistance-gene-transfer-in-non-o157-shiga-toxin-producing-escherichia-coli-strains
#5
Roholla Taghadosi, Mohammad Reza Shakibaie, Reza Ghanbarpour, Hossein Hosseini-Nave
Background and Objectives: The objectives of this study were to evaluate the antibiotic resistance profiles, biofilm formation, presence of antigen 43 (Ag43) gene, and transfer of antibiotic resistance phenotype among non-O157 Shiga toxin producing Escherichia coli (STEC). Materials and Methods: From October 2014 to November 2015 a total of 276 stool samples were collected from healthy calves, goats and 395 patients with the sign of nonbloody diarrhea and screened for presence of stx and serotype O157 genes by polymerase chain reaction (PCR) technique...
April 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29209288/antimicrobial-effects-of-sulfonyl-derivative-of-2-5h-furanone-against-planktonic-and-biofilm-associated-methicillin-resistant-and-susceptible-staphylococcus-aureus
#6
Irshad S Sharafutdinov, Elena Y Trizna, Diana R Baidamshina, Maria N Ryzhikova, Regina R Sibgatullina, Alsu M Khabibrakhmanova, Liliya Z Latypova, Almira R Kurbangalieva, Elvira V Rozhina, Mareike Klinger-Strobel, Rawil F Fakhrullin, Mathias W Pletz, Mikhail I Bogachev, Airat R Kayumov, Oliwia Makarewicz
The gram-positive opportunistic bacterium Staphylococcus aureus is one of the most common causatives of a variety of diseases including skin and skin structure infection or nosocomial catheter-associated infections. The biofilm formation that is an important virulence factor of this microorganism renders the antibiotic therapy ineffective, because biofilm-embedded bacteria exhibit strongly increased tolerance to antimicrobials. Here, we describe a novel 3-chloro-5(S)-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4-[4-methylphenylsulfonyl]-2(5H)-furanone (F105), possessing a sulfonyl group and l-menthol moiety...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29207350/mobile-genetic-elements-and-antibiotic-resistance-in-mine-soil-amended-with-organic-wastes
#7
Carlos Garbisu, Olatz Garaiyurrebaso, Anders Lanzén, Itxaso Álvarez-Rodríguez, Lide Arana, Fernando Blanco, Kornelia Smalla, Elisabeth Grohmann, Itziar Alkorta
Metal resistance has been associated with antibiotic resistance due to co- or cross-resistance mechanisms. Here, metal contaminated mine soil treated with organic wastes was screened for the presence of mobile genetic elements (MGEs). The occurrence of conjugative IncP-1 and mobilizable IncQ plasmids, as well as of class 1 integrons, was confirmed by PCR and Southern blot hybridization, suggesting that bacteria from these soils have gene-mobilizing capacity with implications for the dissemination of resistance factors...
December 2, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29204285/molecular-characterization-of-acinetobacter-baumannii-isolated-from-iraqi-hospital-environment
#8
I M S Al-Kadmy, A N M Ali, I M A Salman, S S Khazaal
Healthcare-associated items are a common source of acquired infections, and hospital-acquired infections cause significant mortality and morbidity worldwide. Acinetobacter baumannii is the most prevalent infection-causing organism in the hospital environment. Hospital articles and objects are the main sources of infection with the ability to transmit some of the pathogenic microorganisms such as A. baumannii, which is considered a serious problem in therapeutic treatments. In the current study, we isolated A...
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29204271/genome-sequencing-and-analysis-of-the-first-spontaneous-nanosilver-resistant-bacterium-proteus-mirabilis-strain-scdr1
#9
Amr T M Saeb, Khalid A Al-Rubeaan, Mohamed Abouelhoda, Manojkumar Selvaraju, Hamsa T Tayeb
Background: P. mirabilis is a common uropathogenic bacterium that can cause major complications in patients with long-standing indwelling catheters or patients with urinary tract anomalies. In addition, P. mirabilis is a common cause of chronic osteomyelitis in Diabetic foot ulcer (DFU) patients. We isolated P. mirabilis SCDR1 from a Diabetic ulcer patient. We examined P. mirabilis SCDR1 levels of resistance against Nanosilver colloids, the commercial Nanosilver and silver containing bandages and commonly used antibiotics...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29203432/propionibacterium-acnes-prosthetic-joint-infection-diagnosis-and-treatment
#10
REVIEW
P Boisrenoult
Propionibacterium acnes is a commensal skin bacterium, regularly implicated in prosthetic joint infection, particularly of the shoulder. Diagnosis has been improved by progress in bacteriological techniques: longer culture time, liquid medium culture, MALDI-TOF mass spectrography, and universal 16S rRNA PCR, associated by some authors to sonication of ablated implants. P. acnes pathogenicity involves many virulence factors, notably including biofilm formation. P. acnes may lead to infection that is clinically evident or, frequently, relatively asymptomatic...
December 1, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29202342/d-tyrosine-loaded-nanocomposite-membranes-for-environmental-friendly-long-term-biofouling-control
#11
Cong Yu, Jinjian Wu, Gilherme Zin, Marco Di Luccio, Donghui Wen, Qilin Li
Strategies to control biofouling without using antimicrobial chemicals are needed to prevent the spread of antibiotic resistance genes and disruption of microbial activities in biological treatment. This study developed an environmentally friendly biofouling resistant membrane by incorporating d-tyrosine onto a commercial nanofiltration membrane using FAU type zeolite nanoparticles that covalently bound to the membrane surface as carriers for slow release. The d-tyrosine loaded membrane had similar water permeability as the unmodified membrane, but greatly reduced initial cell attachment and strongly inhibited subsequent biofilm formation without inactivating the bacteria...
November 14, 2017: Water Research
https://www.readbyqxmd.com/read/29191009/prediction-of-broad-spectrum-pathogen-attachment-to-coating-materials-for-biomedical-devices
#12
Paulius Mikulskis, Andrew L Hook, Adam Dundas, Derek J Irvine, Olutoba Sanni, Daniel G Anderson, Robert Langer, Morgan Russell Alexander, Paul Williams, David A Winkler
Bacterial infections in healthcare settings are a frequent accompaniment to both routine procedures such as catheterization and surgical site interventions. Their impact is becoming even more marked as the numbers of medical devices that are used to manage chronic health conditions and improve quality of life increases. The resistance of pathogens to multiple antibiotics is also increasing, adding an additional layer of complexity to the problems of employing safe and effective medical procedures. One approach to reducing the rate of infections associated with implanted and indwelling medical devices is the use of polymers that resist the formation of bacterial biofilms...
December 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29187848/kaempferol-inhibits-the-primary-attachment-phase-of-biofilm-formation-in-staphylococcus-aureus
#13
Di Ming, Dacheng Wang, Fengjiao Cao, Hua Xiang, Dan Mu, Junjie Cao, Bangbang Li, Ling Zhong, Xiaoyun Dong, Xiaobo Zhong, Lin Wang, Tiedong Wang
The ability to form biofilms on surfaces makes Staphylococcus aureus the main pathogenic factor in implanted medical device infections. The aim of this study was to discover a biofilm inhibitor distinct from the antibiotics used to prevent infections resulting from S. aureus biofilms. Here, we describe kaempferol, a small molecule with anti-biofilm activity that specifically inhibited the formation of S. aureus biofilms. Crystal violet (CV) staining and fluorescence microscopy clearly showed that 64 μg/ml kaempferol inhibited biofilm formation by 80%...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29178982/microbiology-and-associated-risk-factors-in-alloplastic-total-joint-infections-a-20-year-retrospective-study
#14
Rhae Riegel, Kevin Sweeney, Gino Inverso, Peter Quinn, Eric J Granquist
PURPOSE: Prosthetic joint infection (PJI) is a rare complication of temporomandibular joint replacement (TJR). This study evaluated TJR PJIs at the authors' institution over a 20-year period, including micro-organisms cultured, antibiotic resistance patterns, and intraoperative protocols of TJR. PATIENTS AND METHODS: Patients were identified using Current Procedural Terminology and International Classification of Diseases, Ninth Revision codes and surgical logs from January 1995 through 2015...
November 8, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29178590/meloxicam-inhibits-biofilm-formation-and-enhances-antimicrobial-agents-efficacy-by-pseudomonas-aeruginosa
#15
Pengfei She, Yangxia Wang, Zhen Luo, Lihua Chen, Ruichen Tan, Yanle Wang, Yong Wu
Microbial biofilms are communities of surface-adhered cells enclosed in a matrix of extracellular polymeric substances. Bacterial cells in biofilm are 10~1,000-fold more resistant to antimicrobials than the planktonic cells. Burgeoning antibiotic resistance in Pseudomonas aeruginosa biofilm has necessitated the development of antimicrobial agents. Here, we have investigated the antibiofilm effect of meloxicam against P. aeruginosaPAO1 and its potential mechanisms. Further, we have explored whether meloxicam could enhance the susceptibility of bacterial biofilms to treatment with conventional antimicrobials...
November 27, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/29175074/staphylococcus-aureus-and-staphylococcus-epidermidis-infections-on-implants
#16
REVIEW
Weslley F Oliveira, Priscila M S Silva, Rayane C S Silva, Germana M M Silva, Giovanna Machado, Luana C B B Coelho, Maria T S Correia
BACKGROUND: Infections are one of the main reasons for removal of implants from patients, and usually need difficult and expensive treatments. Staphylococcus aureus and Staphylococcus epidermidis are the most frequent pathogens. AIM: To review the epidemiology and pathogenesis of implant-related infections. METHODS: Relevant studies were identified by electronic searching of the following databases: PubMed, ScienceDirect, Academic Google and CAPES Journal Portal...
November 21, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29166860/msaabcr-operon-is-involved-in-persister-cell-formation-in-staphylococcus-aureus
#17
Gyan S Sahukhal, Shanti Pandey, Mohamed O Elasri
BACKGROUND: Persister cells comprise a phenotypic variant that shows extreme antibiotic tolerance resulting in treatment failures of bacterial infections. While this phenomenon has posed a great threat in public health, mechanisms underlying their formation in Staphylococcus aureus remain largely unknown. Increasing evidences of the presence of persister cells in recalcitrant infections underscores the great urgency to unravel the mechanism by which these cells develop. Previously, we characterized msaABCR operon that plays roles in regulation of virulence, biofilm development and antibiotic resistance...
November 22, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/29163397/functionality-of-root-associated-bacteria-along-a-salt-marsh-primary-succession
#18
Miao Wang, Erqin Li, Chen Liu, Alexandre Jousset, Joana F Salles
Plant-associated bacteria are known for their high functional trait diversity, from which many are likely to play a role in primary and secondary succession, facilitating plant establishment in suboptimal soils conditions. Here we used an undisturbed salt marsh chronosequence that represents over 100 years of soil development to assess how the functional traits of plant associated bacteria respond to soil type, plant species and plant compartment. We isolated and characterized 808 bacterial colonies from the rhizosphere soil and root endosphere of two salt marsh plants, Limonium vulgare and Artemisia maritima, along the chronosequence...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163392/clonal-expansion-of-biofilm-forming-salmonella-typhimurium-st34-with-multidrug-resistance-phenotype-in-the-southern-coastal-region-of-china
#19
Wanli Li, Yinghui Li, Yao Liu, Xiaolu Shi, Min Jiang, Yiman Lin, Yaqun Qiu, Qian Zhang, Qiongcheng Chen, Li Zhou, Qun Sun, Qinghua Hu
To disclose the antibiotics susceptibility and wide adaptability of commonly occurring genotypes of Salmonella Typhimurium, the antibiotic resistance and biofilm formation of different multi-locus sequence typing (MLST) types of a collection of 240 S. Typhimurium isolates (33 food and 207 clinical ones) during 2010-2014 in Shenzhen were analyzed. Among these strains, 167 was ST34 (69.58%), and 57 was ST19 (23.75%), respectively. A total of 159 (95.21%) ST34 strains displayed the multidrug resistant phenotype (≥ three classes of antibiotic), whereas only 23 (40...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29162873/rapid-in-situ-imaging-and-whole-genome-sequencing-of-biofilm-in-neonatal-feeding-tubes-a-clinical-proof-of-concept
#20
Pauline Ogrodzki, Chi Shing Cheung, Mohamed Saad, Khaled Dahmani, Rebecca Coxill, Haida Liang, Stephen J Forsythe
The bacterial flora of nasogastric feeding tubes and faecal samples were analysed for a low-birth weight (725 g) neonate EGA 25 weeks in intensive care. Samples were collected at age 6 and 8 weeks of life. Optical coherence tomography (OCT) was used to visualise bacterial biofilms inside the nasogastric feeding tubes. The biofilm was heterogeneously distributed along the tube lumen wall, and had a depth of up to 500 µm. The bacterial biofilm and faecal samples included Enterococcus faecalis and Enterobacter hormaechei...
November 21, 2017: Scientific Reports
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