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https://www.readbyqxmd.com/read/29702448/new-pyrazolopyridine-analogs-synthesis-antimicrobial-antiquorum-sensing-and-antitumor-screening
#1
N S El-Gohary, M I Shaaban
New pyrazolopyridine analogs were prepared and tested for antimicrobial efficacy toward Staphylococcus aureus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Aspergillus fumigatus and Aspergillus flavus. Results revealed that compound 6 has prominent and broad spectrum antimicrobial activity. Compound 8 showed good antibacterial efficacy over the four tested bacterial strains. In addition, compounds 2-4 displayed interesting efficacy over S. aureus, B. cereus and P. aeruginosa as well as moderate efficacy toward E...
April 11, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29522803/assessment-of-the-antibiofilm-and-antiquorum-sensing-activities-of-eucalyptus-globulus-essential-oil-and-its-main-component-1-8-cineole-against-methicillin-resistant-staphylococcus-aureus-strains
#2
Abderrahmen Merghni, Emira Noumi, Ons Hadded, Neyla Dridi, Harsh Panwar, Ozgur Ceylan, Maha Mastouri, Mejdi Snoussi
Antibacterial resistance is an increasingly serious threat to global public health. The search for new anti-infection agents from natural resources, with different mode of actions and competitive effects became a necessity. In this study, twenty height methicillin-resistant Staphylococcus aureus (MRSA) strains were investigated for their biofilm formation ability. Subsequently, the antibiofilm effects of Eucalyptus globulus essential oil and its main component 1,8-cineole, against MRSA, as well as their antiquorum sensing potential, were evaluated...
March 6, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29334239/antimicrobial-and-antiquorum-sensing-activity-of-ricinus-communis-extracts-and-ricinine-derivatives
#3
Mai H El-Naggar, Abdelaziz Elgaml, Fatma M Abdel Bar, Farid A Badria
Ricinine (1), a known major alkaloid in Ricinus communis plant, was used as a starting compound for the synthesis of six ricinine derivatives; two new and four known compounds. The new derivatives; 3-amino-5-methyl-1H-pyrazolo[4,3-c]pyridin-4(5H)-one (2), and 3-amino-5-methyl-1-(phenylsulfonyl)-1H-pyrazolo[4,3-c]pyridin-4(5H)-one (3), as well as the previously prepared derivatives (4-7) were subjected for antimicrobial and antiquorum-sensing evaluation in comparison to different R. communis extracts. Acetyl ricininic acid derivative (5) showed the highest antimicrobial activity among all tested derivatives against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeuroginosa and Candida albicans...
January 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29172966/antiquorum-sensing-activity-of-seed-oils-from-oleaginous-plants-and-protective-effect-during-challenge-with-chromobacterium-violaceum
#4
Macrina Pérez-López, Rodolfo García-Contreras, Marcos Soto-Hernández, José Salud Rodríguez-Zavala, Mariano Martínez-Vázquez, Francisco Javier Prado-Galbarro, Israel Castillo-Juárez
Seed oils from oleaginous plants are rich in fatty acids (FAs) that play important roles in the health of the consumers. Recent studies indicate that FA also can play an important role in communication and regulation of virulence in bacteria. Nevertheless, evidence demonstrating protection against bacterial infections mediated by their quorum sensing inhibition (QSI) activity is scarce. In this study, sunflower, chia, and amaranth oils, were assayed for their QSI capacity by inhibiting violacein production and alkaline exoprotease activity of Chromobacterium violaceum...
April 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29098138/antiquorum-sensing-activity-of-silver-nanoparticles-in-p-aeruginosa-an-in-silico-study
#5
Syed Ghazanfar Ali, Mohammad Azam Ansari, Qazi Mohd Sajid Jamal, Haris M Khan, Mohammad Jalal, Hilal Ahmad, Abbas Ali Mahdi
Pseudomonas aeruginosa an opportunistic pathogen regulates its virulence through Quorum sensing (QS) mechanism comprising of Las and Rhl system. Targeting of QS mechanism could be an ideal strategy to combat infection caused by P . aeruginosa . Silver nanoparticles (AgNPs) have been broadly applied as antimicrobial agents against a number of pathogenic bacterial and fungal strains, but have not been reported as an anti-QS agent. Therefore, the aim of present work was to show the computational analysis for the interaction of AgNPs with the QS system using an In silico approach...
2017: In Silico Pharmacology
https://www.readbyqxmd.com/read/29091715/antiquorum-sensing-antibiofilm-formation-and-cytotoxicity-activity-of-commonly-used-medicinal-plants-by-inhabitants-of-borabu-sub-county-nyamira-county-kenya
#6
Eric Omori Omwenga, Andreas Hensel, Susana Pereira, Alfred Anakalo Shitandi, Francisco M Goycoolea
Productions of various bacterial traits like production of virulence factors (e.g. toxins, enzymes), biofilm formation, luminescence among others, have been known to be controlled by quorum sensing (QS), a process that is dependent on chemical signals or autoinducers (AIs). Bacteria known to rely on such AIs are known to be virulent and tend to be resistant against various antimicrobial agents. Therefore, strategies aimed at the inhibition of QS pathways, are regarded as potential novel therapies in managing bacterial virulence hence reducing their ability to induce infections in humans...
2017: PloS One
https://www.readbyqxmd.com/read/28926764/synthesis-antimicrobial-antiquorum-sensing-antitumor-and-cytotoxic-activities-of-new-series-of-cyclopenta-hepta-b-thiophene-and-fused-cyclohepta-b-thiophene-analogs
#7
Somaya A Abdel-Rahman, Nadia S El-Gohary, Eman R El-Bendary, Saadia M El-Ashry, Mona I Shaaban
New series of cyclopenta(hepta)[b]thiophene and fused cyclohepta[b]thiophene analogs were synthesized. The new analogs were assessed for antibacterial efficacy toward Escherichia coli ATCC 12435, Bacillus cereus UW 85 and Staphylococcus aureus. Compounds 5a, 6b and 12 showed eminent activity toward all selected bacterial strains compared to ampicillin. The antifungal efficacy of the same analogs was also examined toward Candida albicans and Aspergillus fumigatus 293, whereas 5a,b and 12 showed excellent efficacy toward both of the tested fungi...
November 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28623814/synthesis-antimicrobial-antiquorum-sensing-and-antitumor-activities-of-new-benzimidazole-analogs
#8
N S El-Gohary, M I Shaaban
New benzimidazole analogs were prepared and tested for antimicrobial efficacy toward Escherichia coli ATCC 12435, Bacillus cereus UW 85, Staphylococcus aureus ATCC 29213, Candida albicans and Aspergillus fumigatus 293. Results indicated that compound 10 has potent and broad spectrum antimicrobial activity. In addition, 4b and 5c showed eminent antimicrobial efficacy toward B. cereus, S. aureus, C. albicans and A. fumigatus. Furthermore, 12 and 14 demonstrated interesting antifungal activity toward C. albicans...
September 8, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28552808/phytochemical-composition-anti-biofilm-and-anti-quorum-sensing-potential-of-fruit-stem-and-leaves-of-salvadora-persica-l-methanolic-extracts
#9
Emira Noumi, Mejdi Snoussi, Abderrahmen Merghni, Filomena Nazzaro, Guillermo Quindós, Gültekin Akdamar, Maha Mastouri, Abdulbasset Al-Sieni, Ozgur Ceylan
Emergence of antibiotic resistance among pathogenic bacteria encourages us to search for new molecules as an alternative treatment. The aim of this study was to evaluate the antiquorum sensing (anti-QS) and antibiofilm potential of Salvadora persica L. methanolic extracts to prevent the infections due to Staphylococcus as an alternate to antibiotics. The methanolic extracts of S. persica L. fruit, leaves and stems was assessed for their activity in inhibiting QS-depedent phenomenon such as violacein pigment production in Chromobacterium violaceum, swarming motility of Pseudomonas aeruginosa PAO1 and biofilm formation in oral Staphylococcus strains on polymethylmetacrylate (PMMA)...
August 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28334654/synthesis-and-biological-evaluation-of-a-new-series-of-benzimidazole-derivatives-as-antimicrobial-antiquorum-sensing-and-antitumor-agents
#10
N S El-Gohary, M I Shaaban
New benzimidazole derivatives were synthesized and assessed for antimicrobial efficacy toward Escherichia coli, Bacillus cereus, Staphylococcus aureus, Candida albicans and Aspergillus fumigatus 293. Results indicated that compounds 3c and 3n have promising activity toward S. aureus, whereas 3i exhibited remarkable efficacy toward B. cereus. Moreover, compound 3c was proved to be the most active antifungal analog toward C. albicans. On the other hand, 3n displayed the highest activity against A. fumigatus 293...
May 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27849583/quorum-sensing-controls-the-pseudomonas-aeruginosa-crispr-cas-adaptive-immune-system
#11
Nina M Høyland-Kroghsbo, Jon Paczkowski, Sampriti Mukherjee, Jenny Broniewski, Edze Westra, Joseph Bondy-Denomy, Bonnie L Bassler
CRISPR-Cas are prokaryotic adaptive immune systems that provide protection against bacteriophage (phage) and other parasites. Little is known about how CRISPR-Cas systems are regulated, preventing prediction of phage dynamics in nature and manipulation of phage resistance in clinical settings. Here, we show that the bacterium Pseudomonas aeruginosa PA14 uses the cell-cell communication process, called quorum sensing, to activate cas gene expression, to increase CRISPR-Cas targeting of foreign DNA, and to promote CRISPR adaptation, all at high cell density...
January 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27603708/quorum-quenching-and-microbial-control-through-phenolic-extract-of-eugenia-uniflora-fruits
#12
Adeline Conceição Rodrigues, Flávia Guimarães Zola, Brígida D' Ávila Oliveira, Nayara Thais Barbosa Sacramento, Elis Regina da Silva, Michele Corrêa Bertoldi, Jason Guy Taylor, Uelinton Manoel Pinto
We describe the characterization of the centesimal composition, mineral and phenolic content of Eugenia uniflora fruit and the determination of the antioxidant, antimicrobial and quorum quenching activities of the pulp phenolic extract. Centesimal composition was determined according to standard methods; trace elements were measured by total reflection X-ray fluorescence spectroscopy. The phenolic compounds were extracted by solid-phase chromatography and quantified by spectrophotometry. Antioxidant activity was determined by using 3 different methods...
October 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27230628/attenuation-of-adhesion-biofilm-formation-and-quorum-sensing-of-campylobacter-jejuni-by-euodia-ruticarpa
#13
Katja Bezek, Marija Kurinčič, Elvira Knauder, Anja Klančnik, Peter Raspor, Franz Bucar, Sonja Smole Možina
Thermophilic campylobacters are a major cause of bacterial food-borne diarrhoeal disease. Adherence and biofilm formation are key elements of Campylobacter jejuni persistence in unfavourable environmental conditions. The phytochemical analysis of Euodia ruticarpa fruit ethanol solution extract (EREE) indicated that the major compounds were evodiamine (1), rutaecarpine (2) and evocarpine (9). E. ruticarpa fruit ethanol solution extract, compounds 1 and 2 as well as a mixture of quinolinone alkaloids with 41...
September 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/26904749/inhibition-of-quorum-sensing-controlled-virulence-factors-and-biofilm-formation-in-pseudomonas-aeruginosa-by-culture-extract-from-novel-bacterial-species-of-paenibacillus-using-a-rat-model-of-chronic-lung-infection
#14
Saad Musbah Alasil, Rahmat Omar, Salmah Ismail, Mohd Yasim Yusof
Quorum sensing (QS) is a key regulator of virulence factors and biofilm formation in Gram-negative bacteria such as Pseudomonas aeruginosa. Microorganisms that inhabit soil are of strategic importance in the discovery of compounds with anti-QS properties. The objective of the study was to test the culture extract of a taxonomically novel species of Paenibacillus strain 139SI for its inhibitory effects on the QS-controlled virulence factors and biofilm formation of Pseudomonas aeruginosa both in vitro and in vivo...
2015: International Journal of Bacteriology
https://www.readbyqxmd.com/read/26654469/targeting-quorum-sensing-by-designing-azoline-derivatives-to-inhibit-the-n-hexanoyl-homoserine-lactone-receptor-cvir-synthesis-as-well-as-biological-and-theoretical-evaluations
#15
Alejandro Bucio-Cano, Alicia Reyes-Arellano, José Correa-Basurto, Martiniano Bello, Jenifer Torres-Jaramillo, Héctor Salgado-Zamora, Everardo Curiel-Quesada, Javier Peralta-Cruz, Alcives Avila-Sorrosa
To counteract bacterial resistance, we investigated the interruption of quorum sensing mediated by non-classical bioisosteres of the N-hexanoyl homoserine lactone with an azoline core. For this purpose, a set of selected 2-substituted azolines was synthesized, establishing the basis for a new protocol to synthesize 2-amino imidazolines. The synthesized compounds were evaluated as inhibitors of violacein production in Chromobacterium violaceum. Theoretical studies on bioisostere-protein interactions were performed using CviR...
December 15, 2015: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/26264659/in-vitro-antibiofilm-activity-of-the-freshwater-bryozoan-hyalinella-punctata-a-case-study-of-pseudomonas-aeruginosa-pao1
#16
Boris Pejin, Ana Ciric, Ivo Karaman, Mladen Horvatovic, Jasmina Glamoclija, Milos Nikolic, Marina Sokovic
The antibiofilm and possible antiquorum sensing effects against the strain Pseudomonas aeruginosa PAO1 of five crude extracts of the freshwater bryozoan Hyalinella punctata (Hancock, 1850) were evaluated in vitro for the first time. H. punctata ethyl acetate extract (HpEtAc) exhibited the highest antibiofilm activity reducing the biofilm formation of P. aeruginosa PAO1 in the range of 80.63-88.13%. While all tested extracts reduced the twitching motility of the aforementioned bacterial strain, HpEtAc showed to be the most effective...
August 2016: Natural Product Research
https://www.readbyqxmd.com/read/26081038/synthesis-antimicrobial-antiquorum-sensing-and-cytotoxic-activities-of-new-series-of-isoindoline-1-3-dione-pyrazolo-5-1-a-isoindole-and-pyridine-derivatives
#17
Nadia S El-Gohary, Mona I Shaaban
New series of isoindoline-1,3-diones 2-9, pyrazolo[5,1-a]isoindoles 10-14, and pyridines 16-18 were synthesized. Twenty of the synthesized compounds were screened for their antibacterial activity against S. aureus, B. cereus, and E. coli. Compound 5 was proved to be the most active member in this study, showing the highest antibacterial activity against the three selected microorganisms. The antifungal activity of these compounds was also tested against C. albicans and A. flavus 3375. Compounds 4, 5, 8, and 17a exhibited the best antifungal activity against A...
September 2015: Archiv der Pharmazie
https://www.readbyqxmd.com/read/26000026/trigonella-foenum-graceum-seed-extract-interferes-with-quorum-sensing-regulated-traits-and-biofilm-formation-in-the-strains-of-pseudomonas-aeruginosa-and-aeromonas-hydrophila
#18
Fohad Mabood Husain, Iqbal Ahmad, Mohd Shahnawaz Khan, Nasser Abdulatif Al-Shabib
Trigonella foenum-graecum L. (Fenugreek) is an important plant of the Leguminosae family known to have medicinal properties. However, fraction based antiquorum sensing and antibiofilm activities have not been reported from this plant. In the present study T. foenum-graecum seed extract was sequentially fractionated and sub-MICs were tested for above activities. The methanol fraction of the extract demonstrated significant inhibition of AHL regulated virulence factors: protease, LasB elastase, pyocyanin production, chitinase, EPS, and swarming motility in Pseudomonas aeruginosa PAO1 and PAF79...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/25804063/antiquorum-from-freshwater-zoosporic-isolated-fungi-maximization-of-some-ameliorative-factors
#19
Essam Mohamed Ahmed, Mohamed Ibrahim Farag Ammar
Many bacteria detect their critical cell numbers through a mechanism known as quorum sensing (QS). Acyl homoserine lactones (AHLs) mediated QS systems have been shown to operate in important human pathogens. The aim of this study was to evaluate the inhibitory effect generated by zoosporic freshwater fungi on AHLs production. A potent strain of zoosporic fungi, Leptolegniella keratinophilum, was isolated after extended screening study. A new cheap medium was used to support the anti-AHLs activities. Statistical strategy depending on two levels factorial model and three levels quadratic model were applied to guide a production maximization process...
2014: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/25773477/antimicrobial-and-antiquorum-sensing-studies-part-3-synthesis-and-biological-evaluation-of-new-series-of-1-3-4-thiadiazoles-and-fused-1-3-4-thiadiazoles
#20
Nadia S El-Gohary, Mona I Shaaban
New series of [1,3,4]thiadiazoles and fused [1,3,4]thiadiazoles were synthesized. The newly synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus, Bacillus cereus, and Escherichia coli. Compounds 3b and 10a displayed the highest activity against E. coli with MIC value of 78.125 μg/mL. In addition, compound 10a exhibited the highest activity against B. cereus with MIC value of 156.25 μg/mL. The antifungal activity of these compounds was also tested against Candida albicans and Aspergillus flavus 3375...
April 2015: Archiv der Pharmazie
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