Eman M Elattar, Mona Shaban, Hassan-Elrady A Saad, Farid A Badria, Amal A Galala
Vanillin ( 1 ), the main constituent of vanilla species, was used as a starting natural scaffold for the synthesis of five new ( 2 - 6 ) and one known ( 7 ) triazole derivatives via click chemistry using the copper (I)-catalyzed azide-alkyne cycloaddition method. Vanillin and its new derivatives; 4-{1-[2-Hydroxymethyl-5-(5 methyl-2,4-dioxo-3,4-dihydro-2 H -pyrimidin-1-yl)-tetrahydro-furan-3-yl]-1 H [1,2,3]triazol-4-ylmethoxy}-3-methoxy-benzaldehyde ( 2 ); [4-(4-Formyl-2methoxy-phenoxymethyl)-[1,2,3]triazol-1-yl]-acetic acid methyl ester ( 3 ); 4-[1-(4-Acetyl-phenyl)-1 H -[1,2,3]triazol-4-ylmethoxy]-3-methoxy-benzaldehyde ( 4 ); 4-[4-(1-Benzyl-1 H -[1,2,3]triazol-4-ylmethoxy)-3-methoxy-phenyl]-but-3-en-2-one ( 5 ); and 4-[4-(1-Benzyl-1 H -[1,2,3]triazol-4-ylmethoxy)-3-methoxy-phenyl]-4-hydroxy-butan-2-one ( 6 ), as well as the previously known derivative ( 7 ) were subjected to antimicrobial, antiquorum-sensing and cytotoxic evaluation...
October 4, 2022: Natural Product Research