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antibiofilm activities

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https://www.readbyqxmd.com/read/28429871/potentiation-of-antibiotic-against-psedomonas-aeruginosa-biofilm-a-study-with-plumbagin-and-gentamicin
#1
Priya Gupta, Arpita Sarkar, Padmani Sandhu, Akshay Daware, Manash C Das, Yusuf Akhter, Surajit Bhattacharjee
AIM: Pseudomonas aeruginosa is one of the fatal biofilm forming pathogens which pose to be a problem in clinical infections, contamination of food and marine ecosystems. In this report a napthoquinone - Plumbagin has been explored for its antimicrobial (antibacterial and antibiofilm) activity against P. aeruginosa biofilm. The ability of Plumbagin to enhance the bioactivity of a known broad spectrum antibiotic was further assayed by combining the sub-MIC doses of Plumbagin with sub-MIC doses of Gentamicin against P...
April 21, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28422484/direct-synthesis-of-dextran-based-antibacterial-hydrogels-for-extended-release-of-biocides-and-eradication-of-topical-biofilms
#2
Jiaul Hoque, Jayanta Haldar
Cationic small molecular biocides have been developed as promising antibiofilm agents because of their tunability in chemical structures and ability to disrupt established biofilms. However, the impact of biocides in antibiofilm treatment is largely limited due to lack of an effective delivery system that can ensure sustained release of biocide at the target site. Herein we report biocide-encapsulated antibacterial and antibiofilm hydrogel that acts as efficient delivery vehicle for the biocide and eradicates matured bacterial biofilm...
April 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28420830/antimicrobial-and-antibiofilm-activities-of-mta-supplemented-with-bismuth-lipophilic-nanoparticles
#3
Rene Hernandez-Delgadillo, Casiano Del Angel-Mosqueda, Juan Manuel Solís-Soto, Silvia Munguia-Moreno, Nayely Pineda-Aguilar, Rosa Isela Sánchez-Nájera, Shankararaman Chellam, Claudio Cabral-Romero
The objective of this work was to determine the antimicrobial and antibiofilm properties of mineral trioxide aggregate (MTA) supplemented with bismuth lipophilic nanoparticles (BisBAL NPs). The antimicrobial activity of the composite MTA-BisBAL NPs was determined by the disk diffusion assay, while antibiofilm activity was analyzed by fluorescence microscopy. The cytotoxicity of MTA-BisBAL NPs was determined on human gingival fibroblasts by optical microscopy and crystal violet staining. MTA-BisBAL NPs inhibited the growth of Enterococcus faecalis, Escherichia coli, and Candida albicans and also detached the biofilm of fluorescent E...
April 18, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28417087/screening-for-antibacterial-and-antibiofilm-activity-in-thai-medicinal-plant-extracts-against-oral-microorganisms
#4
Rawee Teanpaisan, Pajaree Kawsud, Nuntiya Pahumunto, Jindaporn Puripattanavong
To evaluate the antibacterial activity of 12 ethanol extracts of Thai traditional herb against oral pathogens. The antibacterial activities were assessed by agar well diffusion, broth microdilution, and time-kill methods. Antibiofilm activity was investigated using a 3-[4,5-dimethyl-2-thiazolyl]-2,5-diphenyl-2H-tetrazolium-bromide (MTT) assay. High performance liquid chromatography (HPLC), thin layer chromatography (TLC) fingerprinting, and TLC-bioautography were used to determine the active antibacterial compounds...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28415444/formulation-of-thermoreversible-gel-of-cranberry-juice-concentrate-evaluation-biocompatibility-studies-and-its-antimicrobial-activity-against-periodontal-pathogens
#5
Rajeshwari H R, Dinesh Dhamecha, Satveer Jagwani, Dhanashree Patil, Satisha Hegde, Raksha Potdar, Renuka Metgud, Sunil Jalalpure, Subarna Roy, Kiran Jadhav, Neeraj Kumar Tiwari, Sravani Koduru, Shweta Hugar, Suneel Dodamani
The present work aims to investigate the efficacy of thermoreversible gel of cranberry juice concentrate (CJC) as local drug delivery for the treatment of periodontitis. CJC was initially tested for its antimicrobial activities like MIC, MBC, antiadhesion, antibiofilm and time kill assay against the panel of organisms (S. mutans (SM), E. faecalis (EF), A. actinomycetemcomitans (AA), P. gingivalis (PG), T. forsythia (TF)) responsible for periapical and periodontal infections. Antimicrobial activity of CJC showed MIC value of 50mg/ml and MBC value of 100mg/ml with desirable antiadhesion (83-90%) and antibiofilm activity (70-85%)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28409425/instant-green-synthesis-of-silver-based-herbo-metallic-colloidal-nanosuspension-in-terminalia-bellirica-fruit-aqueous-extract-for-catalytic-and-antibacterial-applications
#6
Sandeep Patil, Gunjan Chaudhari, Jayasinh Paradeshi, Raghunath Mahajan, Bhushan L Chaudhari
In the present study, microwave-assisted, optimized, instant, Terminalia bellirica fruit extract-mediated green synthesis of colloidal silver nanoparticles (AgNPs) has been reported. The synthesized AgNPs were characterized by UV-Vis spectroscopy, FTIR, Zetasizer, FESEM, EDX and XRD. The characteristic surface plasmon peak of reaction mixture at 406 nm confirmed the synthesis of AgNPs. The FTIR studies confirmed phytoconstituents were responsible for the synthesis and stability of AgNPs. The FESEM, EDX and XRD analysis revealed the presence of spherical silver nanoparticles of mean diameter ≤20...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28408902/the-naturally-occurring-host-defense-peptide-ll-37-and-its-truncated-mimetics-ke-18-and-kr-12-have-selected-biocidal-and-antibiofilm-activities-against-candida-albicans-staphylococcus-aureus-and-escherichia-coli-in-vitro
#7
Yu Luo, Denise T F McLean, Gerard J Linden, Danny F McAuley, Ronan McMullan, Fionnuala T Lundy
Amongst the recognized classes of naturally occurring antimicrobials, human host defense peptides are an important group with an advantage (given their source) that they should be readily translatable to medicinal products. It is also plausible that truncated versions will display some of the biological activities of the parent peptide, with the benefit that they are less costly to synthesize using solid-phase chemistry. The host defense peptide, LL-37, and two truncated mimetics, KE-18 and KR-12, were tested for their inhibitory effects and antibiofilm properties against Candida albicans, Staphylococcus aureus, and Escherichia coli, microorganisms commonly implicated in biofilm-related infections such as ventilator-associated pneumonia (VAP)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28407906/antioxidant-and-antibiofilm-activities-of-secondary-metabolites-from-ziziphus-jujuba-leaves-used-for-infusion-preparation
#8
Silvia Damiano, Martino Forino, Arpan De, Luca A Vitali, Giulio Lupidi, Orazio Taglialatela-Scafati
Ziziphus jujuba Mill., jujube, leaf infusions are popular bedtime beverages as they improve sleep by soothing the nerves. With the aim of providing further insights into the polyphenol content of jujube leaf infusion and their antioxidant activities, a 2,2-diphenyl-1-picrylhydrazyl (DPPH)-guided purification of the aqueous extract of Z. jujuba Mill. leaves was conducted. Three major antioxidant polyphenols (i.e. quercitrin, catechin and gallocatechin) of the leaves were identified. In addition, a significant antibiofilm bioactivity against Streptococcus mutans, a causative agent of human dental caries, was detected for the aqueous leaf extract and its bio-guided separation resulted in the identification of the lupane triterpenoid alphitolic acid as the main antibiofilm metabolite...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28401944/lignin-graft-polyoxazoline-conjugated-triazole-a-novel-anti-infective-ointment-to-control-persistent-inflammation
#9
Denial Mahata, Malabendu Jana, Arundhuti Jana, Abhishek Mukherjee, Nibendu Mondal, Tilak Saha, Subhajit Sen, Golok B Nando, Chinmay K Mukhopadhyay, Ranadhir Chakraborty, Santi M Mandal
Lignin, one of the most abundant renewable feedstock, is used to develop a biocompatible hydrogel as anti-infective ointment. A hydrophilic polyoxazoline chain is grafted through ring opening polymerization, possess homogeneous spherical nanoparticles of 10-15 nm. The copolymer was covalently modified with triazole moiety to fortify the antimicrobial and antibiofilm activities. The hydrogel was capable of down regulating the expression level of IL-1β in LPS induced macrophage cells, and to cause significant reduction of iNOS production...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28399162/hydrophobic-pinning-with-copper-nanowhiskers-leads-to-bactericidal-properties
#10
Ajay Vikram Singh, Semanur Baylan, Byung-Wook Park, Gunther Richter, Metin Sitti
The considerable morbidity associated with hospitalized patients and clinics in developed countries due to biofilm formation on biomedical implants and surgical instruments is a heavy economic burden. An alternative to chemically treated surfaces for bactericidal activity started emerging from micro/nanoscale topographical cues in the last decade. Here, we demonstrate a putative antibacterial surface using copper nanowhiskers deposited by molecular beam epitaxy. Furthermore, the control of biological response is based on hydrophobic pinning of water droplets in the Wenzel regime, causing mechanical injury and cell death...
2017: PloS One
https://www.readbyqxmd.com/read/28396543/a-topical-hydrogel-with-deferiprone-and-gallium-protoporphyrin-targets-bacterial-iron-metabolism-and-has-antibiofilm-activity
#11
Katharina Richter, Nicky Thomas, Jolien Claeys, Jonathan McGuane, Clive A Prestidge, Tom Coenye, Peter-John Wormald, Sarah Vreugde
Many infectious diseases are associated with multidrug-resistant (MDR) bacteria residing in biofilms that require high antibiotic concentrations. Whilst oral drug-delivery is frequently ineffective, topical treatments have the potential to deliver higher drug concentrations to the infection-site while reducing systemic side-effects.This study determined the antibiofilm activity of a surgical wound-gel loaded with the iron-chelator deferiprone (Def) and the heme-analogue gallium-protoporphyrin (GaPP), alone and in combination with ciprofloxacin...
April 10, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28390963/targeting-biofilms-of-multidrug-resistant-bacteria-with-silver-oxynitrate
#12
Lindsay R Kalan, Deanna M Pepin, Imran Ul-Haq, Steve B Miller, Michelle E Hay, Rod Precht
A topical antimicrobial, silver oxynitrate (Ag7NO11), has recently become available that exploits the antimicrobial activity of ionic silver but has enhanced activity because highly oxidised silver atoms are stabilised with oxygen in a unique chemical formulation. The objective of this study was to use a multifaceted approach to characterise the spectrum of antimicrobial and antibiofilm activity of a wound dressing coated with Ag7NO11 at a concentration of 0.4 mg Ag/cm(2). Physiochemical properties that influence efficacy were also evaluated, and Ag7NO11 was found to release a high level of Ag ions, including Ag(2+) and Ag(3+), without influencing the pH of the medium...
April 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28390465/antibiofilm-activity-of-five-different-endodontic-filling-materials-used-in-primary-teeth-using-confocal-laser-scanning-microscopy
#13
Katerine Jahnecke Pilownic, Ceci Nunes Carvalho, Ana Regina Romano, Renata Dornelles Morgental, Ya Shen, Markus Haapasalo, Fernanda Geraldo Pappen
PURPOSE: The purpose of this study was to evaluate the effect of five endodontic materials for primary teeth on in vitro mixed-species biofilms. METHODS: Zinc oxide eugenol (ZOE) cement, Vitapex, Calen paste thickened with zinc oxide (ZO), pure calcium hydroxide (Ca(OH)2) paste, and iodoform were evaluated. Sterile water was used as a control. Mixed-species biofilm was incubated in anaerobic conditions for 21 days. The biofilm specimens were placed in contact with the endodontic materials for periods of seven and 30 days...
March 15, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/28383253/structure-activity-relationship-of-membrane-targeting-cationic-ligands-on-a-silver-nanoparticle-surface-in-an-antibiotic-resistant-antibacterial-and-antibiofilm-activity-assay
#14
Xiaomei Dai, Xuelei Chen, Jing Zhao, Yu Zhao, Qianqian Guo, Tianqi Zhang, Chunli Chu, Xinge Zhang, Chaoxing Li
To explore the structure-activity relationship of membrane-targeting cationic ligands on a silver nanoparticle surface in an antibiotic-resistant antibacterial and antibiofilm activity assay, a series of functionalized silver nanocomposites were synthesized. Tuning the structural configuration, molecular weight, and side-chain length of the cationic ligands on the nanoparticle surface provided silver nanocomposites with effective antibacterial activity against both antibiotic-resistant Gram-negative and Gram-positive bacteria, including bacterial biofilms...
April 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28379095/an-insight-into-the-antibiofilm-properties-of-costa-rican-stingless-bee-honeys
#15
L G Zamora, C J Beukelman, A J J van den Berg, P C Aerts, H C Quarles van Ufford, R Nijland, M L Arias
OBJECTIVE: There is an increasing search for antibiofilm agents that either have specific activity against biofilms or may act in synergy with antimicrobials. Our objective is to examine the the antibiofilm properties of stingless bee honeys. METHOD: Meliponini honeys from Costa Rica were examined along with Medihoney as a reference. All honeys were submitted to a screening composed of minimum inhibitory concentration, inhibition of biofilm formation and biofilm destruction microplate-based assays against a Staphylococcus aureus biofilm forming strain...
April 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28378802/histones-from-avian-erythrocytes-exhibit-antibiofilm-activity-against-methicillin-sensitive-and-methicillin-resistant-staphylococcus-aureus
#16
Megan Rose-Martel, Garima Kulshreshtha, Nahom Ahferom Berhane, Joelle Jodoin, Maxwell T Hincke
Staphylococcus aureus, a human pathogen associated with many illnesses and post-surgical infections, can resist treatment due to the emergence of antibiotic-resistant strains and through biofilm formation. The current treatments for chronic biofilm infections are antibiotics and/or surgical removal of the contaminated medical device. Due to higher morbidity and mortality rates associated with overuse/misuse of antibiotics, alternate treatments are essential. This study reports the antibiofilm activity of avian erythrocyte histones against methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA)...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28377235/facile-green-synthesis-of-baicalein-fabricated-gold-nanoparticles-and-their-antibiofilm-activity-against-pseudomonas-aeruginosa-pao1
#17
Jobina Rajkumari, Siddhardha Busi, Aneesh Cherukunnel Vasu, Palarajasekhar Reddy
Biofilm formation is one of the major problems associated with chronic diseases and also attributes for the antibiotic resistance in bacteria. In recent times nanoparticles have been utilized to improve the efficacy of the existing antimicrobial and anti-biofilm agents. The ease in functionalization of gold nanoparticles (AuNPs) makes them a potential carrier for antimicrobial agents. However, the use of physical or chemical methods of the production of nanoparticles is expensive, labour intensive and hazardous to ecosystem...
April 2, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28370752/insights-into-chitosan-antibiofilm-activity-against-methicillin-resistant-s-aureus
#18
E M Costa, S Silva, F K Tavaria, M M Pintado
AIMS: Chitosan is a natural compound that has been validated as a viable antimicrobial agent against Staphylococcus aureus. With this work we sought to evaluate the planktonic and sessile sensitivity of methicillin resistance S. aureus to chitosan's activity and evaluate if MRSA would be more or less sensitive to chitosan's activity than MSSA. METHODS AND RESULTS: A group comprised of reference strains and clinical multiresistant isolates of MSSA and MRSA were used...
March 29, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28357646/the-usefulness-of-non-toxic-plant-metabolites-in-the-control-of-bacterial-proliferation
#19
Sergio Gutiérrez, Alfredo Morán, Honorina Martínez-Blanco, Miguel A Ferrero, Leandro B Rodríguez-Aparicio
The effect of generally recognised as safe (GRAS) plant metabolites in regulating the growth of human pathogenic and probiotic bacteria and in the formation of biofilm was investigated. Thymol, carvacrol and eugenol showed the strongest antibacterial action against both pathogenic and probiotic microorganisms, at a subinhibitory concentration (SIC) of ≤50 μg ml(-1). Genistein, hydroquinone, p-hydroxybenzoic acid and resveratrol also showed antibacterial effects but at a wide concentration range (SIC = 50-1000 μg ml(-1))...
March 29, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28343241/in-vitro-activity-of-alpha-mangostin-in-killing-and-eradicating-staphylococcus-epidermidis-rp62a-biofilms
#20
Murugesan Sivaranjani, Manivannan Prakash, Shanmugaraj Gowrishankar, Janarthanam Rathna, Shunmugiah Karutha Pandian, Arumugam Veera Ravi
Alpha-mangostin (α-MG) has been reported to be an effective antibacterial agent against planktonic cells of many Gram-positive bacteria. However, the antibiofilm potency of α-MG remains unexplored till date. In this study, the antibiofilm and mature biofilm eradication ability of α-MG against Staphylococcus epidermidis RP62A (ATCC 35984) biofilms were evaluated. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of α-MG against S. epidermidis RP62A were found to be 1...
March 25, 2017: Applied Microbiology and Biotechnology
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