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https://www.readbyqxmd.com/read/29166609/gpr56-adgrg1-inhibits-mesenchymal-differentiation-and-radioresistance-in-glioblastoma
#1
Marta Moreno, Leire Pedrosa, Laia Paré, Estela Pineda, Leire Bejarano, Josefina Martínez, Veerakumar Balasubramaniyan, Ravesanker Ezhilarasan, Naveen Kallarackal, Sung-Hak Kim, Jia Wang, Alessandra Audia, Siobhan Conroy, Mercedes Marin, Teresa Ribalta, Teresa Pujol, Antoni Herreros, Avelina Tortosa, Helena Mira, Marta M Alonso, Candelaria Gómez-Manzano, Francesc Graus, Erik P Sulman, Xianhua Piao, Ichiro Nakano, Aleix Prat, Krishna P Bhat, Núria de la Iglesia
A mesenchymal transition occurs both during the natural evolution of glioblastoma (GBM) and in response to therapy. Here, we report that the adhesion G-protein-coupled receptor, GPR56/ADGRG1, inhibits GBM mesenchymal differentiation and radioresistance. GPR56 is enriched in proneural and classical GBMs and is lost during their transition toward a mesenchymal subtype. GPR56 loss of function promotes mesenchymal differentiation and radioresistance of glioma initiating cells both in vitro and in vivo. Accordingly, a low GPR56-associated signature is prognostic of a poor outcome in GBM patients even within non-G-CIMP GBMs...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166015/structure-of-zncl2-melt-part-ii-fragile-to-strong-transition-in-a-tetrahedral-liquid
#2
Pierre Lucas, Garrett J Coleman, Manga Venkateswara Rao, Angharad Naomi Edwards, Chrishani Devaadithya, Shuai Wei, Abduljabar Qassem Alsayoud, Barrett G Potter, Krishna Muralidharan, Pierre A Deymier
The fraction of edge- and corner-sharing tetrahedra in liquid ZnCl2 is quantified as a function of temperature using Raman spectroscopy and ab initio molecular dynamic simulations. Two distinct regimes are found in the temperature dependence of the change in these structural units. This behavior is consistent with the existence of a fragile-to-strong transition in liquid ZnCl2 suggested by calorimetric and viscosity measurements. The structural origin of this transition is rationalized in terms of a constraint counting formalism...
November 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29165921/impact-of-flue-gas-compounds-on-microalgae-and-mechanisms-for-carbon-assimilation-and-utilization-a-review
#3
Arun Krishna Vuppaladadiyam, Joseph G Yao, Nicholas Florin, Anthe George, Xiaoxiong Wang, Leen Labeeuw, Yuelu Jiang, Ryan W Davis, Ali Abbas, Peter Ralph, Paul S Fennell, Ming Zhao
In order to shift the world to a more sustainable future, it is necessary to phase out the use of fossil fuels and focus on the development of low-carbon alternatives. However, this transition is slow so there still exists a large dependence on fossil-derived power and therefore CO2 release. Owing to the potential for assimilating and utilizing CO2 to generate carbon neutral products such as biodiesel, the application of microalgae technology to capture CO2 from flue gases has gained significant attention over the past decade...
November 22, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29165850/the-tcp4-transcription-factor-regulates-trichome-cell-differentiation-by-directly-activating-glabrous-inflorescence-stems-in-arabidopsis-thaliana
#4
B Vijaya Lakshmi Vadde, Krishna Reddy Challa, Utpal Nath
Trichomes are the first cell type to be differentiated during the morphogenesis of leaf epidermis and serve as an ideal model to study cellular differentiation. A large number of genes involved in the patterning and differentiation of trichome cells have been studied over past decades, and the majority of these genes encode transcription factors that specifically regulate epidermal cell development. However, the upstream regulators of these genes that link early leaf morphogenesis with cell type differentiation are less studied...
November 22, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29163847/a-relative-increase-in-circulating-platelets-following-chemoradiation-predicts-for-poor-survival-of-patients-with-glioblastoma
#5
Keeratikarn Boonyawan, Kenneth R Hess, Jie Yang, Lihong Long, Qianghu Wang, Ravesanker Ezhilarasan, Alessandra Auia, Kristin D Alfaro-Munoz, John F de Groot, Krishna P Bhat, Erik P Sulman
Background: Thrombocytosis is triggered by and promotes tumor growth. The relationship between the change in circulating platelets after chemoradiation therapy (CRT) or adjuvant temozolomide (TMZ) and survival in glioblastoma remains unclear. We hypothesized that an increase in platelets after these treatments would be predictive of a shorter survival. Methods: We retrospectively reviewed data on 122 patients with newly diagnosed, pathologically proven glioblastoma who had been treated with surgery, followed by CRT and adjuvant TMZ, from 2007 to 2016...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163746/genetic-insights-into-cerebrovascular-disorders-a-comprehensive-review
#6
Fawaz Al-Mufti, Ahmed Alkanaq, Krishna Amuluru, Rolla Nuoman, Ahmed Abdulrazzaq, Tamarah Sami, Halla Nuoaman, Caroline Hayes-Rosen, Charles J Prestigiacomo, Chirag D Gandhi
No abstract text is available yet for this article.
October 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29163064/turtle-flexion-reflex-motor-patterns-show-windup-mediated-partly-by-l-type-calcium-channels
#7
Keith P Johnson, Stephen M Tran, Emily A Siegrist, Krishna B Paidimarri, Matthew S Elson, Ari Berkowitz
Windup is a form of multisecond temporal summation in which identical stimuli, delivered seconds apart, trigger increasingly strong neuronal responses. L-type Ca(2+) channels have been shown to play an important role in the production of windup of spinal cord neuronal responses, initially in studies of turtle spinal cord and later in studies of mammalian spinal cord. L-type Ca(2+) channels have also been shown to contribute to windup of limb withdrawal reflex (flexion reflex) in rats, but flexion reflex windup has not previously been described in turtles and its cellular mechanisms have not been studied...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29162892/silencing-of-osgrxs17-in-rice-improves-drought-stress-tolerance-by-modulating-ros-accumulation-and-stomatal-closure
#8
Ying Hu, Qingyu Wu, Zhao Peng, Stuart A Sprague, Wei Wang, Jungeun Park, Eduard Akhunov, Krishna S V Jagadish, Paul A Nakata, Ninghui Cheng, Kendal D Hirschi, Frank F White, Sunghun Park
Glutaredoxins (GRXs) modulate redox-dependent signaling pathways and have emerged as key mediators in plant responses to environmental stimuli. Here we report that RNAi-mediated suppression of Oryza sativa GRXS17 (OsGRXS17) improved drought tolerance in rice. Gene expression studies showed that OsGRXS17 was present throughout the plant and that transcript abundance increased in response to drought stress and abscisic acid (ABA) treatment. Localization studies, utilizing GFP-OsGRXS17 fusion proteins, indicated that OsGRXS17 resides in both the cytoplasm and the nuclear envelope...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162143/prevalence-and-risk-of-hepatitis-e-virus-infection-in-the-hiv-population-of-nepal
#9
Ananta Shrestha, Anurag Adhikari, Manjula Bhattarai, Ramanuj Rauniyar, Jose D Debes, André Boonstra, Thupten K Lama, Mamun Al Mahtab, Amna Subhan Butt, Sheikh Mohammad Fazle Akbar, Nirmal Aryal, Sapana Karn, Krishna Das Manandhar, Birendra Prasad Gupta
BACKGROUND: Infection with the hepatitis E virus (HEV) can cause acute hepatitis in endemic areas in immune-competent hosts, as well as chronic infection in immune-compromised subjects in non-endemic areas. Most studies assessing HEV infection in HIV-infected populations have been performed in developed countries that are usually affected by HEV genotype 3. The objective of this study is to measure the prevalence and risk of acquiring HEV among HIV-infected individuals in Nepal. METHODS: We prospectively evaluated 459 Human Immunodeficiency Virus (HIV)-positive individuals from Nepal, an endemic country for HEV, for seroprevalence of HEV and assessed risk factors associated with HEV infection...
November 21, 2017: Virology Journal
https://www.readbyqxmd.com/read/29161464/increased-efficiency-of-targeted-mutagenesis-by-crispr-cas9-in-plants-using-heat-stress
#10
Chantal Le Blanc, Fei Zhang, Josefina Mendez, Yamile Lozano, Krishna Chatpar, Vivian Irish, Yannick Jacob
The CRISPR/Cas9 system has greatly improved our ability to engineer targeted mutations in eukaryotic genomes. While CRISPR/Cas9 appears to work universally, the efficiency of targeted mutagenesis and the adverse generation of off-target mutations vary greatly between different organisms. In this study, we report that Arabidopsis plants subjected to heat stress at 37°C show much higher frequencies of CRISPR-induced mutations compared to plants grown continuously at the standard temperature (22°C). Using quantitative assays relying on GFP reporter genes, we found that targeted mutagenesis by CRISPR/Cas9 in Arabidopsis is increased by ~5-fold in somatic tissues and up to 100-fold in the germline upon heat treatment...
November 21, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29161050/fecl3-mediated-domino-reaction-of-benzoxazinones-with-aroylmethylidene-malonates-synthesis-to-functionalized-pyrrolobenzoxazines
#11
Shweta Bisht, Rama Krishna Peddinti
An efficient domino approach for the synthesis of pyrrolobenzoxazine derivatives is described. The FeCl3-promoted domino reaction between aroylmethylidene malonates and benzoxazinones has been successfully established to afford the title compounds in good to excellent yield under mild reaction conditions. The domino protocol provides a concise and straightforward access to highly substituted pyrrolobenzoxazines with high efficiency and excellent functional group tolerance.
November 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29159274/novel-investigative-modalities-for-evaluation-of-pancreatic-cystic-lesions-does-increased-diagnostic-accuracy-justify-the-high-costs
#12
EDITORIAL
Somashekar G Krishna
No abstract text is available yet for this article.
October 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29159256/cirrhosis-of-liver-interference-of-serpins-in-quantification-of-serpina4-a-preliminary-study
#13
Krishna Sumanth Nallagangula, K N Shashidhar, V Lakshmaiah, C Muninarayana
Background: Cirrhosis of liver is a pathological condition, wherein functions of liver are impaired by chronic liver exploitations. Due to decrease in synthetic capacity, expressions of plasma proteins tend to decrease in blood stream. Serpins (Serine protease inhibitors) are class of plasma proteins expressed from liver with structural similarities and diverse functions. SERPINA4 (Kallistatin) is a multifunctional serpin clade A protein expressed from liver and concentration in serum is the reflection of extent of liver dysfunction...
December 2017: Pract Lab Med
https://www.readbyqxmd.com/read/29158549/hypoxia-inducible-factor-1%C3%AE-mediates-the-profibrotic-effect-of-albumin-in-renal-tubular-cells
#14
Junping Hu, Weili Wang, Fan Zhang, Pin-Lan Li, Krishna M Boini, Fan Yi, Ningjun Li
Proteinuria is closely associated with the progression of chronic kidney diseases (CKD) by producing renal tubulointerstitial fibrosis. Over-activation of hypoxia inducible factor (HIF)-1α has been implicated in the progression of CKD. The present study tested the hypothesis that HIF-1α mediates albumin-induced profibrotic effect in cultured renal proximal tubular cells. Incubation of the cells with albumin (40 μg/ml) for 72 hrs significantly increased the protein levels of HIF-1α, tissue inhibitor of metalloproteinase (TIMP)-1 and collagen-I, which were blocked by HIF-1α shRNA...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29157912/new-paradigm-in-ankyrin-repeats-beyond-protein-protein-interaction-module
#15
REVIEW
Zeyaul Islam, Raghavendra Sashi Krishna Nagampalli, Munazza Tamkeen Fatima, Ghulam Md Ashraf
Classically, ankyrin repeat (ANK) proteins are built from tandems of two or more repeats and form curved solenoid structures that are associated with protein-protein interactions. These are short, widespread structural motif of around 33 amino acids repeats in tandem, having a canonical helix-loop-helix fold, found individually or in combination with other domains. The multiplicity of structural pattern enables it to form assemblies of diverse sizes, required for their abilities to confer multiple binding and structural roles of proteins...
November 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29157242/development-and-validation-of-a-structured-observation-scale-to-measure-responsiveness-of-physicians-in-rural-bangladesh
#16
Taufique Joarder, Ilias Mahmud, Malabika Sarker, Asha George, Krishna Dipankar Rao
BACKGROUND: Responsiveness of physicians is the social actions that physicians do to meet the legitimate expectations of service seekers. Since there is no such scale, this study aimed at developing one for measuring responsiveness of physicians in rural Bangladesh, by structured observation method. METHODS: Data were collected from Khulna division of Bangladesh, through structured observation of 393 patient-consultations with physicians. The structured observation tool consisted of 64 items, with four Likert type response categories, each anchored with a defined scenario...
November 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29155813/post-guidance-signaling-by-extracellular-matrix-associated-slit-slit-n-maintains-fasciculation-and-position-of-axon-tracts-in-the-nerve-cord
#17
Krishna Moorthi Bhat
Axon-guidance by Slit-Roundabout (Robo) signaling at the midline initially guides growth cones to synaptic targets and positions longitudinal axon tracts in discrete bundles on either side of the midline. Following the formation of commissural tracts, Slit is found also in tracts of the commissures and longitudinal connectives, the purpose of which is not clear. The Slit protein is processed into a larger N-terminal peptide and a smaller C-terminal peptide. Here, I show that Slit and Slit-N in tracts interact with Robo to maintain the fasciculation, the inter-tract spacing between tracts and their position relative to the midline...
November 20, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29155283/comparative-analysis-of-media-effects-on-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-in-proarrhythmia-risk-assessment
#18
Derek Schocken, Jayna Stohlman, Jose Vicente, Dulciana Chan, Dakshesh Patel, Murali Krishna Matta, Vikram Patel, Mathew Brock, Daniel Millard, James Ross, David G Strauss, Ksenia Blinova
INTRODUCTION: Cardiotoxicity assessment using human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) forms a key component of the Comprehensive in Vitro Proarrhythmia Assay (CiPA). A potentially impactful factor on iPSC-CM testing is the presence of serum in the experimental media. Generally, serum-free media is used to most accurately reproduce "free" drug concentration. However, caution is needed; drug solubility and cardiomyocyte electrophysiology could be affected by media formulation, potentially impacting interpretation of drug-induced effects...
November 16, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29153769/serum-sodium-response-to-hypertonic-saline-infusion-therapy-in-traumatic-brain-injury
#19
Scott A Chapman, Eric D Irwin, Matthew Thunselle, Alicia Ronk, Patty Reicks, Barb Curran, Krishna Rangarajan, Harrison Tam, Greg J Beilman
No abstract text is available yet for this article.
November 16, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29153693/up-regulation-of-microrna-202-3p-in-first-trimester-placenta-of-pregnancies-destined-to-develop-severe-preeclampsia-a-pilot-study
#20
Krishna Singh, John Williams, Jordan Brown, Erica T Wang, Bora Lee, Tania L Gonzalez, Jinrui Cui, Mark O Goodarzi, Margareta D Pisarska
MicroRNA (miRNA) expression has not been studied during placentation in pregnancies that develop preeclampsia, when it likely manifests. In this pilot study, miRNA expression in late first trimester placenta from four pregnancies that developed severe preeclampsia matched to controls using the Affymetrix GeneChip® miRNA 3.0 Array identified 9 miRNAs differentially expressed, with miR-202-3p the most significantly overexpressed in severe preeclampsia. Real-time reverse transcription polymerase chain reaction (qRT-PCR) confirmed overexpression of miR-202-3p in a validation cohort, with a 7-fold increase in pregnancies that developed severe preeclampsia (p≤0...
October 2017: Pregnancy Hypertension
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