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https://www.readbyqxmd.com/read/28727768/benign-and-tumor-parenchyma-metabolomic-profiles-affect-compensatory-renal-growth-in-renal-cell-carcinoma-surgical-patients
#1
Barak Rosenzweig, Nimrod D Rubinstein, Ed Reznik, Roman Shingarev, Krishna Juluru, Oguz Akin, James J Hsieh, Edgar A Jaimes, Paul Russo, Katalin Susztak, Jonathan A Coleman, A Ari Hakimi
BACKGROUND AND OBJECTIVES: Pre-operative kidney volume is an independent predictor of glomerular filtration rate in renal cell carcinoma patients. Compensatory renal growth (CRG) can ensue prior to nephrectomy in parallel to tumor growth and benign parenchyma loss. We aimed to test whether renal metabolite abundances significantly associate with CRG, suggesting a causative relationship. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: Tissue metabolomics data from 49 patients, with a median age of 60 years, were previously collected and the pre-operative fold-change of their contra to ipsi-lateral benign kidney volume served as a surrogate for their CRG...
2017: PloS One
https://www.readbyqxmd.com/read/28727450/carbon-nanotube-reinforced-polymer-stabilized-liquid-crystal-device-lowered-and-thermally-invariant-threshold-with-accelerated-dynamics
#2
Subbarao Krishna Prasad, Marlin Baral, Adhigan Murali, Sellamuthu N Jaisankar
Polymer stabilized liquid crystal (PSLC) devices comprise a polymer matrix in an otherwise continuous phase of liquid crystal. The fibrils of the polymer provide, even in the bulk, virtual surfaces with finite anchoring energy resulting in attractive electro-optic properties. Here we describe a novel variation of the PSLC device fabricated by reinforcing the polymer matrix with polymer-capped single-walled carbon nanotubes (CNTs). The most important outcome of this strengthening of the polymer strands is that the threshold voltage associated with the electro-optic switching becomes essentially temperature independent in marked contrast to the significant thermal variation seen in the absence of the nanotubes...
July 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28726578/a-framework-for-optimizing-phytosanitary-thresholds-in-seed-systems
#3
Robin Alan Choudhury, Karen A Garrett, Steven J Klosterman, Krishna V Subbarao, Neil McRoberts
Seedborne pathogens and pests limit production in many agricultural systems. Quarantine programs help prevent the introduction of exotic pathogens into a country, but few regulations directly apply to reducing the re-introduction and spread of endemic pathogens. Use of phytosanitary thresholds helps limit the movement of pathogen inoculum through seed, but the costs associated with rejected seed lots can be prohibitive for voluntary implementation of phytosanitary thresholds. In this paper, we outline a framework to optimize thresholds for seedborne pathogens, balancing the cost of rejected seed lots and benefit of reduced inoculum levels...
July 20, 2017: Phytopathology
https://www.readbyqxmd.com/read/28726415/enhanced-diffusion-of-passive-tracers-in-active-enzyme-solutions
#4
Xi Zhao, Krishna Kanti Dey, Selva Jeganathan, Peter J Butler, Ubaldo M Córdova-Figueroa, Ayusman Sen
Colloidal suspensions containing microscopic swimmers have been the focus of recent studies aimed at understanding the principles of energy transfer in fluidic media at low Reynolds number conditions. Going down in scale, active enzymes have been shown to be force-generating, non-equilibrium systems, thus offering opportunity to examine energy transfer at the ultralow Reynolds number regime. By monitoring the change of diffusion of inert tracers dispersed in active enzyme solutions, we demonstrate that the nature of energy transfer in these systems is similar to that reported for larger microscopic active systems, despite the large differences in scale, modes of energy transduction and propulsion...
July 20, 2017: Nano Letters
https://www.readbyqxmd.com/read/28724910/investigating-glycemic-potential-of-rice-by-unraveling-compositional-variations-in-mature-grain-and-starch-mobilization-patterns-during-seed-germination
#5
Maria Krishna de Guzman, Sabiha Parween, Vito M Butardo, Crisline Mae Alhambra, Roslen Anacleto, Christiane Seiler, Anthony R Bird, Chung-Ping Chow, Nese Sreenivasulu
Rice lines with slower starch digestibility provide opportunities in mitigating the global rise in type II diabetes and related non-communicable diseases. However, screening for low glycemic index (GI) in rice breeding programs is not possible due to time and cost constraints. This study evaluated the feasibility of using in vitro cooked grain amylolysis, starch mobilization patterns during seed germination, and variation in starch structure and composition in the mature seed to differentiate patterns of starch digestibility...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724905/flowering-time-in-banana-musa-spp-a-day-neutral-plant-is-controlled-by-at-least-three-flowering-locus-t-homologues
#6
Akhilesh K Chaurasia, Hemant B Patil, Bal Krishna, V R Subramaniam, Prafullachandra V Sane, Aniruddha P Sane
Banana is an important day neutral food crop with a long flowering/fruiting cycle that is affected by hot summers or cold winters in different places. Manipulating its life cycle requires an understanding of its flowering time machinery to bypass these stresses. Twelve FLOWERING LOCUS T (FT) and two TWIN SISTER OF FT (TSF) members were isolated from banana and their organization and expression pattern studied during development in two varieties that differ in flowering time namely Grand Nain (AAA genotype) and Hill banana (AAB genotype)...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28722403/wrinkled-few-layer-graphene-as-highly-efficient-load-bearer
#7
Charalampos Androulidakis, Emmanuel Nicholaos Koukaras, Jaroslava Rahova, Krishna Sampathkumar, John Parthenios, Konstantinos Papagelis, Otakar Frank, Costas Galiotis
Multilayered graphitic materials are not suitable as load-bearers due to their inherent weak interlayer bonding (for example, graphite is a solid lubricant in certain applications). This situation is largely improved when two-dimensional (2-D) materials such as a monolayer (SLG) graphene are employed. The downside in these cases is the presence of thermally or mechanically induced wrinkles which are ubiquitous in 2-D materials. Here we set out to examine the effect of extensive large wavelength/ amplitude wrinkling on the stress transfer capabilities of exfoliated simply-supported graphene flakes...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28721993/honey-and-olive-oil-as-bio-friendly-substitutes-for-formalin-and-xylene-in-routine-histopathology
#8
Keerthi Muddana, Jaya Nagendra Krishna Muppala, Shyam Prasad Reddy Dorankula, Aruna Kumari Maloth, Pavan G Kulkarni, Deepsagar Thadudari
BACKGROUND: Formalin has long been the standard fixative and xylene has been the clearing agent for routine histopathology and immunohistochemistry worldwide. In recent years, as a result of increasing concerns about the potential carcinogenicity of formaldehyde and xylene, attempts have been made to find safer alternatives. In the present study, we considered honey as better alternative for formalin and olive oil as safer substitute for xylene. AIMS: The aim of this study was to know whether honey could be a possible substitute for formalin and olive oil could be a possible substitute for xylene...
May 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28721611/bone-targeting-parathyroid-hormone-conjugates-outperform-unmodified-pth-in-the-anabolic-treatment-of-osteoporosis-in-rats
#9
Yang Yang, Ali Aghazadeh-Habashi, Arash Panahifar, Yuchin Wu, Krishna H Bhandari, Michael R Doschak
Synthetic parathyroid hormone (PTH) is clinically indicated for the treatment of osteoporosis, through its anabolic effects on parathyroid hormone receptors (PTHRs), located on osteoblast cells. However, the bioavailability of PTH for bone cells is restricted by the short half-life of PTH and the widespread distribution of PTHRs in non-skeletal tissues. To impart affinity for mineralized bone surfaces, bisphosphonate (BP)-mediated PTH analogues were synthesized, characterized, and evaluated in vitro and in vivo...
July 18, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28721540/temporal-expression-of-cumulus-cell-marker-genes-during-in-vitro-maturation-and-oocyte-developmental-competence
#10
Arindam Dhali, Pradeep Krishna Javvaji, Atul P Kolte, Joseph Rabinson Francis, Sudhir C Roy, Veerasamy Sejian
PURPOSE: Cumulus cells (CC) play important roles in oocyte development and cumulus expressed genes can be used as markers for oocyte quality. This study aimed to investigate temporal changes in the expression of cumulus marker genes during oocyte maturation as possible biomarkers of embryo developmental competence in ovine. METHODS: Gene expression was assessed in the CC of the BCB+ (developmentally competent) and BCB- (developmentally poor) oocytes at 0, 12, and 24 h of in vitro maturation (IVM)...
July 18, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28719690/for-profit-medical-education-reply
#11
Eli Y Adashi, Gopika R Krishna, Philip A Gruppuso
No abstract text is available yet for this article.
July 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28719574/ancient-european-dog-genomes-reveal-continuity-since-the-early-neolithic
#12
Laura R Botigué, Shiya Song, Amelie Scheu, Shyamalika Gopalan, Amanda L Pendleton, Matthew Oetjens, Angela M Taravella, Timo Seregély, Andrea Zeeb-Lanz, Rose-Marie Arbogast, Dean Bobo, Kevin Daly, Martina Unterländer, Joachim Burger, Jeffrey M Kidd, Krishna R Veeramah
Europe has played a major role in dog evolution, harbouring the oldest uncontested Palaeolithic remains and having been the centre of modern dog breed creation. Here we sequence the genomes of an Early and End Neolithic dog from Germany, including a sample associated with an early European farming community. Both dogs demonstrate continuity with each other and predominantly share ancestry with modern European dogs, contradicting a previously suggested Late Neolithic population replacement. We find no genetic evidence to support the recent hypothesis proposing dual origins of dog domestication...
July 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28718923/using-homology-modeling-to-interrogate-binding-affinity-in-neutralization-of-ricin-toxin-by-a-family-of-single-domain-antibodies
#13
Andrea Bazzoli, David J Vance, Michael J Rudolph, Yinghui Rong, Siva Krishna Angalakurthi, Ronald T Toth, C Russell Middaugh, David B Volkin, David D Weis, John Karanicolas, Nicholas J Mantis
In this report we investigated, within a group of closely related single domain camelid antibodies (VH Hs), the relationship between binding affinity and neutralizing activity as it pertains to ricin, a fast-acting toxin and biothreat agent. The V1C7-like VH Hs (V1C7, V2B9, V2E8, and V5C1) are similar in amino acid sequence, but differ in their binding affinities and toxin-neutralizing activities. Using the X-ray crystal structure of V1C7 in complex with ricin's enzymatic subunit (RTA) as a template, Rosetta-based homology modeling coupled with energetic decomposition led us to predict that a single pairwise interaction between Arg29 on V5C1 and Glu67 on RTA was responsible for the difference in ricin toxin binding affinity between V1C7, a weak neutralizer, and V5C1, a moderate neutralizer...
July 18, 2017: Proteins
https://www.readbyqxmd.com/read/28717543/outcome-analysis-of-transurethral-resection-versus-potassium-titanyl-phosphate-photo-selective-vaporization-of-the-prostate-for-the-treatment-of-benign-prostatic-hyperplasia-a-randomized-controlled-trial-with-4-years-follow-up
#14
Bimalesh Purkait, Rahul Janak Sinha, Krishna Swamy A Srinivas, Ankur Bansal, Ashok Kumar Sokhal, Vishwajeet Singh
OBJECTIVE: Photovaporization of prostate (PVP) is a newer surgical modality of benign prostatic hyperplasia (BPH) which is gaining importance recently. There are a few randomized controlled trials that showed safety and efficacy of PVP in comparison with transurethral resection of prostate (TURP) with limited follow-up period (<2 years). Here, we are presenting a comparative study performed on potassium titanyl phosphate (KTP) PVP laser versus TURP for the treatment of BPH with long-term follow-up period...
June 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28717530/comparative-and-integrative-analysis-of-rna-structural-profiling-data-current-practices-and-emerging-questions
#15
Krishna Choudhary, Fei Deng, Sharon Aviran
BACKGROUND: Structure profiling experiments provide single-nucleotide information on RNA structure. Recent advances in chemistry combined with application of high-throughput sequencing have enabled structure profiling at transcriptome scale and in living cells, creating unprecedented opportunities for RNA biology. Propelled by these experimental advances, massive data with ever-increasing diversity and complexity have been generated, which give rise to new challenges in interpreting and analyzing these data...
March 2017: Quantitative Biology
https://www.readbyqxmd.com/read/28715742/development-of-high-performance-supercapacitor-electrode-derived-from-sugar-industry-spent-wash-waste
#16
Ashesh Mahto, Rajeev Gupta, Krishna Kanta Ghara, Divesh N Srivastava, Pratyush Maiti, Kalpana D, Paul Zavala-Revira, R Meena, S K Nataraj
This study aims at developing supercapacitor materials from sugar and distillery industry wastes, thereby mediating waste disposal problem through reuse. In a two-step process, biomethanated spent wash (BMSW) was acid treated to produce solid waste sludge and waste water with significantly reduced total organic carbon (TOC) and biological oxygen demand (BOD) content. Further, waste sludge was directly calcined in presence of activating agent ZnCl2 in inert atmosphere resulting in high surface area (730-900m(2)g(-1)) carbon of unique hexagonal morphology...
June 23, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28713763/evaluation-of-three-different-processing-techniques-in-the-fabrication-of-complete-dentures
#17
Vamsi Krishna Chintalacheruvu, Rajasekaran Uttukuli Balraj, Lavanya Sireesha Putchala, Sreelekha Pachalla
AIMS AND OBJECTIVES: The objective of the present study is to compare the effectiveness of three different processing techniques and to find out the accuracy of processing techniques through number of occlusal interferences and increase in vertical dimension after denture processing. MATERIALS AND METHODS: A cross-sectional study was conducted on a sample of 18 patients indicated for complete denture fabrication was selected for the study and they were divided into three subgroups...
June 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28712027/concomitant-meniscal-injury-in-anterior-cruciate-ligament-reconstruction%C3%A2-does-not-lead-to-poorer-short-term-post-operative-outcomes
#18
Amritpal Singh, Desmond Thiam Wei, Cheryl Tan Pei Lin, Shen Liang, Saumitra Goyal, Kimberly-Anne Tan, Brian Zhaojie Chin, Lingaraj Krishna
PURPOSE: The main objective was to compare post-operative outcomes in patients undergoing anterior cruciate ligament (ACL) reconstruction both with and without concomitant meniscus injury at a mean follow-up of 3.5 years. The secondary objective was to study the effect of different meniscal injury sites and treatment modalities on post-operative outcomes (PROS). METHODS: This is a retrospective analysis of a prospectively maintained database of patients undergoing ACL reconstruction at our tertiary institution between 2009 and 2012...
July 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28711698/classification-of-mild-cognitive-impairment-eeg-using-combined-recurrence-and-cross-recurrence-quantification-analysis
#19
Leena T Timothy, Bindu M Krishna, Usha Nair
The present study is aimed at the classification of mild cognitive impairment (MCI) EEG by combining complexity and synchronization features based on quantifiers from the common platform of recurrence based analysis. Recurrence rate (RR) of recurrence quantification analysis (RQA) is used for complexity analysis and RR of cross recurrence quantification analysis (CRQA) is used for synchronization analysis. The investigations are carried out on EEG from two states (i) resting eyes closed (EC) and (ii) short term memory task (STM)...
July 12, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28708881/large-anthropogenic-impacts-on-a-charismatic-small-carnivore-insights-from-distribution-surveys-of-red-panda-ailurus-fulgens-in-nepal
#20
Saroj Panthi, Gopal Khanal, Krishna Prasad Acharya, Achyut Aryal, Arjun Srivathsa
Protected areas are key to preserving biodiversity and maintaining ecosystem services. However, their ability to ensure long-term survival of threatened andendangered species varies across countries, regions and landscapes. Distribution surveys can beparticularly important for assessing the value of protected areas, and gauging their efficacy incatering to species-specific requirements. We assessed the conservation value of one such reserve for a charismatic yet globally endangered species, the red panda Ailurus fulgens,in the light of on-going land-use transformation in Nepal...
2017: PloS One
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