keyword
https://read.qxmd.com/read/38536592/three-year-follow-up-analysis-of-the-short-stitch-versus-long-stitch-technique-for-elective-midline-abdominal-closure-randomized-controlled-estoih-trial
#1
JOURNAL ARTICLE
R H Fortelny, A Hofmann, P Baumann, S Riedl, J L Kewer, J Hoelderle, A Shamiyeh, B Klugsberger, T D Maier, G Schumacher, F Köckerling, Ursula Pession, M Schirren, M Albertsmeier
BACKGROUND: Clinical trials have shown reduced incisional hernia rates 1 year after elective median laparotomy closure using a short-stitch technique. With hernia development continuing beyond the first postoperative year, we aimed to compare incisional hernias 3 years after midline closure using short or long stitches in patients from the ESTOIH trial. METHODS: The ESTOIH trial was a prospective, multicenter, parallel-group, double-blind, randomized-controlled study of primary elective midline closure...
March 27, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://read.qxmd.com/read/38536530/the-paradox-of-mri-for-breast-cancer-screening-high-risk-and-dense-breasts-available-evidence-and-current-practice
#2
REVIEW
Francesco Sardanelli, Veronica Magni, Gabriele Rossini, Fleur Kilburn-Toppin, Nuala A Healy, Fiona J Gilbert
In the mid-1990s, the identification of BRCA1/2 genes for breast cancer susceptibility led to testing breast MRI accuracy in screening women at increased risk. From 2000 onwards, ten intraindividual comparative studies showed the marked superiority of MRI: the sensitivity ranged 25-58% for mammography, 33-52% for ultrasound, 48-67% for mammography plus ultrasound, and 71-100% for MRI; specificity 93-100%, 91-98%, 89-98%, and 81-98%, respectively. Based on the available evidence, in 2006-2007, the UK National Institute for Clinical Excellence and the American Cancer Society recommended MRI screening of high-risk women, followed by other international guidelines...
March 27, 2024: Insights Into Imaging
https://read.qxmd.com/read/38535502/functional-gastrointestinal-disorders-quality-of-life-and-behaviour-in-adolescents-with-history-of-infant-colic
#3
JOURNAL ARTICLE
Judith Zeevenhooven, Lucas Zeevenhooven, Angela Biesbroek, Renske Schappin, Arine M Vlieger, Bregje E van Sleuwen, Monique P L'Hoir, Marc A Benninga
AIM: To assess the prevalence of functional gastrointestinal disorders (FGIDs), health-related quality of life (HRQOL), and behavioural problems in a cohort of adolescents with a history of infant colic (IC), as defined by Wessel's criteria. METHODS: 388 adolescents, aged 15-18 years, who participated in a randomised controlled trial for infants with colic, were invited for our observational follow-up study. Prevalence of FGIDs was assessed with the Rome IV Questionnaire on Paediatric Gastrointestinal Disorders (RIV-QPGD), HRQOL through self-report of the Paediatric Quality of Life Inventory (PedsQL), and behavioural problems through parent-report of the child behaviour checklist (CBCL)...
March 27, 2024: Acta Paediatrica
https://read.qxmd.com/read/38534892/mastering-sedation-and-associated-respiratory-events-through-simulation-based-training-a-randomised-controlled-trial-involving-non-anaesthesiology-residents
#4
JOURNAL ARTICLE
Jean-Noël Evain, Tran Do, Hakim Harkouk, Pierre Drolet, Roger Perron, Mihai Georgescu, Arnaud Robitaille, Issam Tanoubi
Non-anaesthetists commonly administer procedural sedation worldwide, posing the risk of respiratory events that can lead to severe complications. This study aimed to evaluate whether simulation-based learning could lead to enhancements in the clinical proficiency of non-anaesthesiology residents in managing sedation and related respiratory complications. Following the evaluation of baseline clinical performance through a pre-test simulation, 34 residents were randomly allocated to either participate in an innovative simulation-based learning module (intervention group) or view a brief self-learning video (control group)...
February 23, 2024: European journal of investigation in health, psychology and education
https://read.qxmd.com/read/38534044/effect-of-a-plant-protein-rich-diet-on-postprandial-phosphate-metabolism-in-healthy-adult-men-a-randomised-controlled-trial
#5
JOURNAL ARTICLE
Kozue Uenishi, Nozomi Kawasaki, Haruka Iseki, Misato Nogata, Yuki Kawabata, Shinsuke Kido
BACKGROUND: This study examined the effects of animal protein- and plant protein-rich diets on postprandial phosphorus metabolism in healthy male subjects. METHODS: The study was conducted by randomised parallel-group comparison of healthy men aged 21-24 years. In Study 1, participants were divided into two groups and consumed either a 70% animal protein diet (AD, n = 6) or a 70% plant protein diet (PD, n = 6). In Study 2, participants were divided into three groups and consumed either AD (n = 10), PD (n = 10) or AD + DF, a 70% animal protein diet loaded with the same amount of fibre as PD (n = 9)...
March 27, 2024: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://read.qxmd.com/read/38534000/microwave-coagulation-for-liver-metastases
#6
REVIEW
Dawid Storman, Mateusz J Swierz, Jerzy W Mitus, Michal Pedziwiatr, Ning Liang, Robert Wolff, Malgorzata M Bala
BACKGROUND: Liver metastases (i.e. secondary hepatic malignancies) are significantly more common than primary liver cancer. Long-term survival after radical surgical treatment is approximately 50%. For people in whom resection for cure is not feasible, other treatments must be considered. One treatment option is microwave coagulation utilising electromagnetic waves. It involves placing an electrode into a lesion under ultrasound or computed tomography guidance. OBJECTIVES: To evaluate the beneficial and harmful effects of microwave coagulation versus no intervention, other ablation methods, or systemic treatments in people with liver metastases regardless of the location of the primary tumour...
March 27, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38533994/mobile-phone-text-messaging-for-medication-adherence-in-secondary-prevention-of-cardiovascular-disease
#7
REVIEW
Julie Redfern, Qiang Tu, Karice Hyun, Matthew A Hollings, Nashid Hafiz, Clara Zwack, Caroline Free, Pablo Perel, Clara K Chow
BACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of death globally, accounting for almost 18 million deaths annually. People with CVDs have a five times greater chance of suffering a recurrent cardiovascular event than people without known CVDs. Although drug interventions have been shown to be cost-effective in reducing the risk of recurrent cardiovascular events, adherence to medication remains suboptimal. As a scalable and cost-effective approach, mobile phone text messaging presents an opportunity to convey health information, deliver electronic reminders, and encourage behaviour change...
March 27, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38533606/a-randomised-controlled-trial-of-medication-adherence-and-management-of-risk-factors-for-secondary-prevention-of-stroke-mamors-using-a-smartphone-based-application
#8
JOURNAL ARTICLE
Veena Babu, P N Sylaja, Biju Soman, Ravi Prasad Varma, Manju M S, G L Geethu, Suresh Kumar
BACKGROUND: There is little data on the use of smartphone-based applications for medication adherence and risk-factor control for the secondary prevention of stroke in low-and-middle-income countries (LMIC). AIMS: To determine whether a smartphone-based app improved medication adherence, risk-factor control, and provided health education to stroke survivors for lifestyle and behavioural modifications. METHODS: An unblinded, single-centre randomized controlled double arm trial with 1:1 allocation among stroke survivors was performed in South India...
March 27, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38533547/effectiveness-of-exercise-intervention-on-physical-and-health-outcomes-in-patients-admitted-to-an-acute-medical-ward-a-systematic-review-and-meta-analysis
#9
JOURNAL ARTICLE
Jane L McCaig, Brett A Gordon, Carolyn J Taylor
OBJECTIVE: To evaluate the effectiveness of inpatient medical ward exercise on physical and health outcomes in adults compared with usual care. DATA SOURCES: Medline, CINAHL and EMBASE were searched from inception to 20 April 2023. REVIEW METHODS: Randomised-controlled trials in English that reported physical and health outcomes of adults who received an exercise intervention on an acute medical ward were included. Two reviewers independently extracted data...
March 27, 2024: Clinical Rehabilitation
https://read.qxmd.com/read/38533281/efficacy-of-pistacia-lentiscus-plant-rumi-mastagi-in-comparison-to-levosulpiride-in-patients-with-diabetic-gastroparesis-a-double-blind-non-inferior-randomised-control-trial-study
#10
JOURNAL ARTICLE
Ajaypal Singh, Ravi Kant, Rohit Raina, Vandana Dhingra, Rajeev Nema, Mukesh Chand Bairwa, Varsha Kanwar, Rifika L Sukhes Mukherjee, Anissa Atif Mirza, Mayank Agarwal
INTRODUCTION: Gastrointestinal neuropathies are frequently found in diabetic patients. The pathogenesis of diabetic gastroparesis (DG) is multifactorial. The usual treatment for DG includes dietary modifications, prokinetic and antiemetic agents. There is increasing demand for more effective medicines to treat DG. The current study was conducted on the Pistacia lentiscus stem extract to add to the armamentarium of DG treatment and to find the efficacy of P. lentiscus plant extract (mastic gum) in comparison to levosulpiride in DG for improvement in gastroparesis symptoms and gastric emptying scintigraphy (GES) in a single centric double-blind non-inferiority randomised control trial...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38532490/precision-computerised-cognitive-behavioural-therapy-ccbt-for-adolescents-with-depression-a-pilot-and-feasibility-randomised-controlled-trial-protocol-for-sparx-uk
#11
JOURNAL ARTICLE
K Khan, C L Hall, C Babbage, S Dodzo, C Greenhalgh, M Lucassen, S Merry, K Sayal, K Sprange, K Stasiak, C R Tench, E Townsend, P Stallard, C Hollis
BACKGROUND: A serious game called SPARX (Smart, Positive, Active, Realistic, X-factor thoughts), originally developed in New Zealand and incorporating cognitive behavioural therapy (CBT) principles, has been shown to help reduce symptoms of depression and anxiety in adolescents with mild to moderate depression in studies undertaken in Australasia. However, SPARX has never been trialled in the United Kingdom (UK), and there have been issues relating to low engagement when it has been used in a real-world context...
March 26, 2024: Pilot and Feasibility Studies
https://read.qxmd.com/read/38532488/clinical-statistical-analysis-plan-for-the-accure-trial-the-effect-of-appendectomy-on-the-clinical-course-of-ulcerative-colitis-a-randomised-international-multicentre-trial
#12
JOURNAL ARTICLE
Eva Visser, Lianne Heuthorst, Shri Pathmakanthan, Willem A Bemelman, Geert R D'Haens, Kelly Handley, Apostolos Fakis, Thomas D Pinkney, Christianne J Buskens, Marcel G W Dijkgraaf
BACKGROUND: The primary treatment of ulcerative colitis (UC) is medical therapy using a standard step-up approach. An appendectomy might modulate the clinical course of UC, decreasing the incidence of relapses and reducing need for medication. The objective of the ACCURE trial is to assess the efficacy of laparoscopic appendectomy in addition to standard medical treatment in maintaining remission in UC patients. This article presents the statistical analysis plan to evaluate the outcomes of the ACCURE trial...
March 26, 2024: Trials
https://read.qxmd.com/read/38532475/pneumococcal-conjugate-vaccination-schedules-in-infants-acquisition-immunogenicity-and-pneumococcal-conjugate-and-yellow-fever-vaccine-co-administration-study-statistical-analysis-plan
#13
JOURNAL ARTICLE
Grant A Mackenzie, Isaac Osei, Rasheed Salaudeen, Paul V Licciardi, Brian Greenwood, Kim Mulholland, Cattram Nguyen
RATIONALE: The effectiveness of immunisation with pneumococcal conjugate vaccine (PCV) has been demonstrated in many countries. However, the global impact of PCV is limited by its cost, which has prevented its introduction in some countries. Reducing the cost of PCV programmes will facilitate further vaccine introductions and improve the sustainability of PCV in low-income countries when they transition from subsidised vaccine supply. We are conducting a large, population-level, cluster-randomised field trial (PVS) of an alternative reduced-dose schedule of PCV compared to the standard schedule...
March 26, 2024: Trials
https://read.qxmd.com/read/38532432/implementing-and-evaluating-group-interpersonal-therapy-for-postnatal-depression-in-lebanon-and-kenya-individually-randomised-superiority-trial
#14
JOURNAL ARTICLE
Peter Fonagy, Rabih El Chammay, Carol Ngunu, Manasi Kumar, Lena Verdeli, Elizabeth Allison, Ghida Anani, Pasco Fearon, Fouad Fouad, Zoe Hoare, Lucina Koyio, Henrietta Moore, Andrew Nyandigisi, Stephen Pilling, Hannah Sender, Jolene Skordis, Rachel Evans, Gerard Joseph Abou Jaoude, Beatrice Madeghe, Sandra Pardi Arsen Maradian, Ciara O'Donnell, Elizabeth Simes, Alexandra Truscott, Grace Nduku Wambua, Obadia Yator
BACKGROUND: Depression ranks as the foremost mental health concern among childbearing women. Within low- and middle-income countries (LMICs), between 20 and 25% of women encounter depression during pregnancy or soon after delivery. This condition impacts not only the mothers but also their offspring. Offspring of women suffering from postnatal depression (PND) exhibit suboptimal cognitive development and increased emotional and behavioural issues throughout their growth. This scenario becomes more pronounced in LMICs, where numerous adversities further jeopardise children's developmental progress...
March 26, 2024: Trials
https://read.qxmd.com/read/38531998/is-there-an-advantage-to-delayed-molar-implant-placement-in-those-with-chronic-apical-periodontitis
#15
JOURNAL ARTICLE
Rabab Ahmad
DESIGN: This paper is a single-centre, double-blinded, prospective randomised control trial, comparing immediate vs delayed implant placement clinically and radiographically in patients with chronic periodontitis, specifically assessing the molar region. Seventy-four patients were recruited to the study over a one-year period, all of whom returned for follow up throughout the study. STUDY SELECTION: The study adhered to the principles outlined in the Declaration of Helsinki and obtained ethical approval from the affiliated University Hospital of Qingdao...
March 26, 2024: Evidence-based Dentistry
https://read.qxmd.com/read/38531700/re-laparoscopic-sacrocolpopexy-versus-vaginal-sacrospinous-fixation-for-vaginal-vault-prolapse-a-randomised-controlled-trial-and-prospective-cohort-salto-2-trial
#16
JOURNAL ARTICLE
Andrea Braga, Andrea Papadia, Maurizio Serati
No abstract text is available yet for this article.
March 25, 2024: European Urology
https://read.qxmd.com/read/38531658/cessation-of-smoking-trial-in-the-emergency-department-costed-a-multicentre-randomised-controlled-trial
#17
JOURNAL ARTICLE
Ian Pope, Lucy V Clark, Allan Clark, Emma Ward, Pippa Belderson, Susan Stirling, Steve Parrott, Jinshuo Li, Tim Coats, Linda Bauld, Richard Holland, Sarah Gentry, Sanjay Agrawal, Benjamin Michael Bloom, Adrian A Boyle, Alasdair J Gray, M Geraint Morris, Jonathan Livingstone-Banks, Caitlin Notley
BACKGROUND: Supporting people to quit smoking is one of the most powerful interventions to improve health. The Emergency Department (ED) represents a potentially valuable opportunity to deliver a smoking cessation intervention if it is sufficiently resourced. The objective of this trial was to determine whether an opportunistic ED-based smoking cessation intervention can help people to quit smoking. METHODS: In this multicentre, parallel-group, randomised controlled superiority trial conducted between January and August 2022, adults who smoked daily and attended one of six UK EDs were randomised to intervention (brief advice, e-cigarette starter kit and referral to stop smoking services) or control (written information on stop smoking services)...
March 26, 2024: Emergency Medicine Journal: EMJ
https://read.qxmd.com/read/38531628/a-rapid-improvement-event-progesterone-prescribing-in-prevention-of-miscarriage
#18
JOURNAL ARTICLE
Lucy Anne Bolger, Nicola O'Riordan, Cathy Allen
A rapid improvement event (RIE) is a standard operational excellence technique that uses team-based problem solving to improve processes. In this study, a RIE was undertaken to improve progesterone prescribing rates for those with a history of miscarriage experiencing vaginal bleeding in early pregnancy. This was on the basis of a recent change in guidelines regarding prescribing in these instances. NICE guidelines changed in November 2021 after Cochrane meta-analysis and the PRISM (Progesterone in Spontaneous Miscarriage) randomised control trial demonstrated a higher incidence of live births in those prescribed vaginal micronised progesterone for threatened miscarriage, when compared with those not prescribed it...
March 26, 2024: BMJ Open Quality
https://read.qxmd.com/read/38531586/effectiveness-and-cost-effectiveness-of-a-sustainable-obesity-prevention-programme-for-preschool-children-delivered-at-scale-henry-health-exercise-nutrition-for-the-really-young-protocol-for-the-henry-iii-cluster-randomised-controlled-trial
#19
JOURNAL ARTICLE
Maria Bryant, Wendy Burton, Michelle Collinson, Adam Martin, Bethan Copsey, Dawn Groves-Williams, Alexis Foster, Thomas A Willis, Philip Garnett, Alicia O'Cathain
INTRODUCTION: One-fifth of children start school already overweight or living with obesity, with rates disproportionately impacting those living in the most deprived areas. Social, environmental and biological factors contribute to excess weight gain and programmes delivered in early years settings aim to support families to navigate these in order to prevent obesity. One of these programmes (Health, Exercise and Nutrition for the Really Young, HENRY) has been delivered in UK community venues (hereon named 'centres') in high deprivation areas since 2008 and aims to help families to provide a healthy start for their preschool children...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531584/intercostal-nerve-cryoablation-versus-thoracic-epidural-analgesia-for-minimal-invasive-nuss-repair-of-pectus-excavatum-a-protocol-for-a-randomised-clinical-trial-ice-trial
#20
JOURNAL ARTICLE
Nicky Janssen, Jean H T Daemen, Aimée J P M Franssen, Elise J van Polen, Lori M van Roozendaal, Karel W E Hulsewé, Yvonne Vissers, Erik R de Loos
INTRODUCTION: Epidural analgesia is currently considered the gold standard in postoperative pain management for the minimally invasive Nuss procedure for pectus excavatum. Alternative analgesic strategies (eg, patient-controlled analgesia and paravertebral nerve block) fail in accomplishing adequate prolonged pain management. Furthermore, the continuous use of opioids, often prescribed in addition to all pain management strategies, comes with side effects. Intercostal nerve cryoablation seems a promising novel technique...
March 25, 2024: BMJ Open
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