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https://www.readbyqxmd.com/read/27933731/independent-risk-factors-for-the-development-of-skin-erosion-due-to-incontinence-incontinence-associated-dermatitis-category-2-in-nursing-home-residents-results-from-a-multivariate-binary-regression-analysis
#1
Nele Van Damme, Karen Van den Bussche, Dorien De Meyer, Ann Van Hecke, Sofie Verhaeghe, Dimitri Beeckman
The aim of this study was to identify characteristics independently associated with a higher risk of developing skin damage because of incontinence [incontinence-associated dermatitis (IAD) category 2] in nursing home residents. As part of a larger randomised controlled trial, IAD incidence was monitored for 1 month in a sample of 381 incontinent residents using a validated IAD Severity Categorisation Tool. Data on demographical, physical, functional and psychological characteristics were collected. The overall IAD incidence (category 1-2) was 30·0%, and 6% of the participants developed skin damage (IAD category 2)...
December 9, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27933685/the-stop-acei-trial-apt-timing-for-this-long-awaited-randomised-controlled-trial-validation-of-the-syndrome-of-late-onset-renal-failure-from-angiotensin-blockade-lorffab
#2
Macaulay Amechi Chukwukadibia Onuigbo
No abstract text is available yet for this article.
December 9, 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27933615/immediate-release-versus-controlled-release-carbamazepine-in-the-treatment-of-epilepsy
#3
REVIEW
Graham Powell, Matthew Saunders, Alexandra Rigby, Anthony G Marson
BACKGROUND: Carbamazepine (CBZ) is a commonly used drug for epilepsy that is associated with troublesome adverse events including dizziness, double vision, drowsiness, poor co-ordination and unsteadiness. These adverse events often occur during peaks in drug plasma concentration. These adverse events may limit the daily dose of CBZ that can be tolerated and reduce the chances of seizure control in patients who require high doses. A controlled-release formulation of CBZ delivers the same dose over a longer period of time when compared to a standard immediate-release formulation, thereby reducing post-dose peaks in CBZ plasma concentration and potentially reducing adverse events...
December 8, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27933614/antiviral-agents-for-infectious-mononucleosis-glandular-fever
#4
REVIEW
Muireann De Paor, Kirsty O'Brien, Tom Fahey, Susan M Smith
BACKGROUND: Infectious mononucleosis (IM) is a clinical syndrome, usually caused by the Epstein Barr virus (EPV), characterised by lymphadenopathy, fever and sore throat. Most cases of symptomatic IM occur in older teenagers or young adults. Usually IM is a benign self-limiting illness and requires only symptomatic treatment. However, occasionally the disease course can be complicated or prolonged and lead to decreased productivity in terms of school or work. Antiviral medications have been used to treat IM, but the use of antivirals for IM is controversial...
December 8, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27933431/effect-of-remote-ischaemic-preconditioning-on-liver-injury-in-patients-undergoing-major-hepatectomy-for-colorectal-liver-metastasis-a-pilot-randomised-controlled-feasibility-trial
#5
Sanjeev Kanoria, Francis P Robertson, Naimish N Mehta, Giuseppe Fusai, Dinesh Sharma, Brian R Davidson
BACKGROUND: Liver resection produces excellent long-term survival for patients with colorectal liver metastases but is associated with significant morbidity and mortality from ischaemia reperfusion injury (IRI). Remote ischaemic preconditioning (RIPC) can reduce the effect of IRI. This pilot randomised controlled trial evaluated RIPC in patients undergoing major hepatectomy at the Royal Free Hospital, London. METHODS: Sixteen patients were randomised to RIPC or sham control...
December 8, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27933328/predictors-of-emesis-in-children-undergoing-procedural-sedation-with-intramuscular-ketamine-in-a-paediatric-emergency-department
#6
Shruthi Suryaprakash, Lai Peng Tham
INTRODUCTION: Emesis is one of the most common adverse events associated with ketamine sedation. However, the predictors of emesis have not been clearly studied among Asian children. This study aimed to determine the incidence and predictors of emesis in local children undergoing intramuscular (IM) ketamine sedation in the emergency department (ED), and identify high-risk groups(s), so that antiemetics may be administered prophylactically. METHODS: In a prospective observational study, all children requiring procedural sedation under IM ketamine in the paediatric ED between 1 April 2013 and 31 January 2015 were included...
December 9, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27932822/feasibility-study-assessing-the-efficacy-and-social-acceptability-of-using-dental-hygienist-therapists-as-front-line-clinicians
#7
R Macey, A M Glenny, P Brocklehurst
Background The oral health of the adult population has been improving in the United Kingdom decade upon decade. Over half of dental service activity in the National Health Service (NHS) is limited to a check-up without any further treatment. This raises a question as to whether check-ups could be provided by dental hygienist-therapists, rather than general dental practitioners. The aim of this study was to assess the feasibility of a definitive trial to evaluate the costs and effects of using dental hygienist-therapists to undertake the check-up...
December 9, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27932629/breathlessness-during-daily-activity-the-psychometric-properties-of-the-london-chest-activity-of-daily-living-scale-in-patients-with-advanced-disease-and-refractory-breathlessness
#8
Charles C Reilly, Claudia Bausewein, Rachel Garrod, Caroline J Jolley, John Moxham, Irene J Higginson
BACKGROUND: The London Chest Activities of Daily Living Scale measures the impact of breathlessness on both activity and social functioning. However, the London Chest Activities of Daily Living Scale is not routinely used in patients with advanced disease. AIM: To assess the psychometric properties of the London Chest Activities of Daily Living Scale in patients with refractory breathlessness due to advanced disease. DESIGN: A cross-sectional secondary analysis of data from a randomised controlled parallel-group, pragmatic, single-blind fast-track trial (randomised controlled trial) investigating the effectiveness of an integrated palliative and respiratory care service for patients with advanced disease and refractory breathlessness, known as the Breathlessness Support Service (NCT01165034)...
December 8, 2016: Palliative Medicine
https://www.readbyqxmd.com/read/27932625/advantages-and-disadvantages-of-graduated-and-inverse-graduated-compression-hosiery-in-patients-with-chronic-venous-insufficiency-and-healthy-volunteers-a-prospective-mono-centric-blinded-open-randomised-controlled-and-cross-over-trial
#9
Helene Riebe, Wolfgang Konschake, Hermann Haase, Michael Jünger
BACKGROUND: The therapeutic effectiveness of compression therapy depends on the selection of compression hosiery. OBJECTIVES: To assess efficacy and tolerability of graduated elastic compression stockings (GECS) and inverse graduated elastic compression stockings (PECS). METHODS: Thirty-two healthy volunteers and thirty-two patients with chronic venous insufficiency were analysed; wear period: one week for each stocking type (randomised, blinded)...
December 8, 2016: Phlebology
https://www.readbyqxmd.com/read/27932540/twelve-month-follow-up-on-a-randomised-controlled-trial-of-relaxation-training-for-post-stroke-anxiety
#10
Katherine Golding, Chris Fife-Schaw, Ian Kneebone
OBJECTIVE: To follow up participants in a randomised controlled trial of relaxation training for anxiety after stroke at 12 months. DESIGN: Twelve month follow-up to a randomised controlled trial, in which the control group also received treatment. SETTING: Community. PARTICIPANTS: Fifteen of twenty one original participants with post-stroke anxiety participated in a one year follow-up study. INTERVENTIONS: A self-help autogenic relaxation CD listened to five times a week for one month, immediately in the intervention group and after three months in the control group...
December 8, 2016: Clinical Rehabilitation
https://www.readbyqxmd.com/read/27932360/the-effects-of-a-high-intensity-functional-exercise-group-on-clinical-outcomes-in-hospitalised-older-adults-an-assessor-blinded-randomised-controlled-trial
#11
Melissa J M Raymond, Kimberley J Jeffs, Adele Winter, Sze-Ee Soh, Peter Hunter, Anne E Holland
OBJECTIVE: to investigate a high-intensity functional exercise (HIFE) group in hospitalised older adults. DESIGN: assessor-blinded, randomised-controlled trial. SETTING: sub-acute wards at a metropolitan rehabilitation hospital. PARTICIPANTS: older adults ≥65 years (n = 468) able to stand with minimum assistance or less from a chair and follow instructions. INTERVENTION: 'group' participants were offered a standing HIFE group three times a week and individual physiotherapy sessions twice a week...
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27932335/multicentre-randomised-placebo-controlled-trial-of-oral-anticoagulation-with-apixaban-in-systemic-sclerosis-related-pulmonary-arterial-hypertension-the-sphinx-study-protocol
#12
Alicia Calderone, Wendy Stevens, David Prior, Harshal Nandurkar, Eli Gabbay, Susanna M Proudman, Trevor Williams, David Celermajer, Joanne Sahhar, Peter K K Wong, Vivek Thakkar, Nathan Dwyer, Jeremy Wrobel, Weng Chin, Danny Liew, Margaret Staples, Rachelle Buchbinder, Mandana Nikpour
INTRODUCTION: Systemic sclerosis (SSc) is a severe and costly multiorgan autoimmune connective tissue disease characterised by vasculopathy and fibrosis. One of the major causes of SSc-related death is pulmonary arterial hypertension (PAH), which develops in 12-15% of patients with SSc and accounts for 30-40% of deaths. In situ thrombosis in the small calibre peripheral pulmonary vessels resulting from endothelial dysfunction and an imbalance of anticoagulant and prothrombotic mediators has been implicated in the complex pathophysiology of SSc-related PAH (SSc-PAH), with international clinical guidelines recommending the use of anticoagulants for some types of PAH, such as idiopathic PAH...
December 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27932265/ottawa-panel-evidence-based-clinical-practice-guidelines-for-structured-physical-activity-in-the-management-of-juvenile-idiopathic-arthritis
#13
REVIEW
Sabrina Cavallo, Lucie Brosseau, Karine Toupin-April, George A Wells, Christine A M Smith, Arlanna G Pugh, Jennifer Stinson, Roanne Thomas, Sara Ahmed, Ciarán M Duffy, Prinon Rahman, Inmaculada C Àlvarez-Gallardo, Laurianne Loew, Gino De Angelis, Debbie Ehrmann Feldman, Annette Majnemer, Isabelle J Gagnon, Désirée Maltais, Marie-Ève Mathieu, Glen P Kenny, Susan Tupper, Kristi Whitney-Mahoney, Sarah Bigford
OBJECTIVE: To create guidelines focused on the use of structured physical activity (PA) in the management of juvenile idiopathic arthritis (JIA). DATA SOURCES: A systematic literature search was conducted using the electronic databases Cochrane Central Register of Controlled Trials, Medline (Ovid), EMBASE (Ovid), and Physiotherapy Evidence Database (PEDro) for all studies related to PA programs for JIA from January 1966 until December 2014, and was updated in May 2015...
December 5, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27932229/regorafenib-for-patients-with-hepatocellular-carcinoma-who-progressed-on-sorafenib-treatment-resorce-a-randomised-double-blind-placebo-controlled-phase-3-trial
#14
Jordi Bruix, Shukui Qin, Philippe Merle, Alessandro Granito, Yi-Hsiang Huang, György Bodoky, Marc Pracht, Osamu Yokosuka, Olivier Rosmorduc, Valeriy Breder, René Gerolami, Gianluca Masi, Paul J Ross, Tianqiang Song, Jean-Pierre Bronowicki, Isabelle Ollivier-Hourmand, Masatoshi Kudo, Ann-Lii Cheng, Josep M Llovet, Richard S Finn, Marie-Aude LeBerre, Annette Baumhauer, Gerold Meinhardt, Guohong Han
BACKGROUND: There are no systemic treatments for patients with hepatocellular carcinoma (HCC) whose disease progresses during sorafenib treatment. We aimed to assess the efficacy and safety of regorafenib in patients with HCC who have progressed during sorafenib treatment. METHODS: In this randomised, double-blind, parallel-group, phase 3 trial done at 152 sites in 21 countries, adults with HCC who tolerated sorafenib (≥400 mg/day for ≥20 of last 28 days of treatment), progressed on sorafenib, and had Child-Pugh A liver function were enrolled...
December 5, 2016: Lancet
https://www.readbyqxmd.com/read/27931888/community-treatment-orders-a-pause-for-thought
#15
Maninder Kaur Nagra, Toby Pillinger, Henrique Prata-Ribeiro, Yasser Khazaal, Andrew Molodynski
Community Treatment Orders (CTO) have been available for several decades in some countries and are being progressively introduced worldwide, with significant uptake in Asian countries as they move more mental health care into the community. However the evidence for the effectiveness of CTOs is limited. The evidence from local audits and evaluations is conflicted with some studies showing clear benefit and others not. The same is the case for uncontrolled before and after studies. The higher levels of evidence such as randomised controlled trials, systematic reviews, and Cochrane reviews have consistently failed to demonstrate benefits from CTO use on key measures such as symptom levels, functioning, and healthcare use...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931870/effects-of-early-mobilisation-in-patients-after-cardiac-surgery-a-systematic-review
#16
REVIEW
P M Ramos Dos Santos, N Aquaroni Ricci, É Aparecida Bordignon Suster, D de Moraes Paisani, L Dias Chiavegato
BACKGROUND: Early mobilisation is prescribed after cardiac surgery to prevent postoperative complications, decrease length of hospital stay, and augment return to daily activities. OBJECTIVE: To evaluate the evidence for the effects of early mobilisation in patients after cardiac surgery on length of hospital stay, functional capacity and postoperative complications. DATA SOURCES: The data sources used were Medline, Embase, CINAHL, PEDro, Web of Science and Cochrane Central Register of Controlled Trials...
September 14, 2016: Physiotherapy
https://www.readbyqxmd.com/read/27931254/feasibility-of-an-online-intervention-stak-d-to-promote-physical-activity-in-children-with-type-1-diabetes-protocol-for-a-randomised-controlled-trial
#17
Holly Blake, Helen Quirk, Paul Leighton, Tabitha Randell, James Greening, Boliang Guo, Cris Glazebrook
BACKGROUND: Regular physical activity has important health benefits for children with type 1 diabetes mellitus (T1DM), yet children and their parents face barriers to participation such as lack of self-efficacy or concerns around hypoglycaemia. Multimedia interventions are useful for educating children about their health and demonstrate potential to improve children's health-related self-efficacy, but few paediatric clinics offer web-based resources as part of routine care. The Steps to Active Kids with Diabetes (STAK-D) programme is an online intervention grounded in psychological theory (social cognitive theory) and informed by extensive preliminary research...
December 8, 2016: Trials
https://www.readbyqxmd.com/read/27931252/the-impact-of-advertising-patient-and-public-involvement-on-trial-recruitment-embedded-cluster-randomised-recruitment-trial
#18
Adwoa Hughes-Morley, Mark Hann, Claire Fraser, Oonagh Meade, Karina Lovell, Bridget Young, Chris Roberts, Lindsey Cree, Donna More, Neil O'Leary, Patrick Callaghan, Waquas Waheed, Peter Bower
BACKGROUND: Patient and public involvement in research (PPIR) may improve trial recruitment rates, but it is unclear how. Where trials use PPIR to improve design and conduct, many do not communicate this clearly to potential participants. Better communication of PPIR might encourage patient enrolment, as trials may be perceived as more socially valid, relevant and trustworthy. We aimed to evaluate the impact on recruitment of directly advertising PPIR to potential trial participants. METHODS: This is a cluster trial, embedded within a host trial ('EQUIP') recruiting service users diagnosed with severe mental illness...
December 8, 2016: Trials
https://www.readbyqxmd.com/read/27931242/achieving-good-outcomes-for-asthma-living-goal-mixed-methods-feasibility-and-pilot-cluster-randomised-controlled-trial-of-a-practical-intervention-for-eliciting-setting-and-achieving-goals-for-adults-with-asthma
#19
Gaylor Hoskins, Brian Williams, Purva Abhyankar, Peter Donnan, Edward Duncan, Hilary Pinnock, Marjon van der Pol, Petra Rauchhaus, Anne Taylor, Aziz Sheikh
BACKGROUND: Despite being a core component of self-management, goal setting is rarely used in routine care. We piloted a primary care, nurse-led intervention called Achieving Good Outcomes for Asthma Living (GOAL) for adults with asthma. Patients were invited to identify and prioritise their goals in preparation for discussing and negotiating an action/coping plan with the nurse at a routine asthma review. METHODS: The 18-month mixed methods feasibility cluster pilot trial stratified and then randomised practices to deliver usual care (UC) or a goal-setting intervention (GOAL)...
December 8, 2016: Trials
https://www.readbyqxmd.com/read/27931214/how-effective-are-volunteers-at-supporting-people-in-their-last-year-of-life-a-pragmatic-randomised-wait-list-trial-in-palliative-care-elsa
#20
Catherine Walshe, Steven Dodd, Matt Hill, Nick Ockenden, Sheila Payne, Nancy Preston, Guillermo Perez Algorta
BACKGROUND: Clinical care alone at the end of life is unlikely to meet all needs. Volunteers are a key resource, acceptable to patients, but there is no evidence on care outcomes. This study aimed to determine whether support from a social action volunteer service is better than usual care at improving quality of life for adults in the last year of life. METHODS: A pragmatic, multi-centre wait-list controlled trial, with participants randomly allocated to receive the volunteer support intervention either immediately or after a 4 week wait...
December 9, 2016: BMC Medicine
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