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https://www.readbyqxmd.com/read/29141179/formation-of-longitudinal-axon-pathways-in-caenorhabditis-elegans
#1
REVIEW
Harald Hutter
The small number of neurons and the simple architecture of the Caenorhabditis elegans (C. elegans) nervous system enables researchers to study axonal pathfinding at the level of individually identified axons. Axons in C. elegans extend predominantly along one of the two major body axes, the anterior-posterior axis and the dorso-ventral axis. This review will focus on axon navigation along the anterior-posterior axis, leading to the establishment of the longitudinal axon tracts, with a focus on the largest longitudinal axon tract, the ventral nerve cord (VNC)...
November 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29140872/an-experimental-investigation-of-implicit-hiv-and-prep-stigma-evidence-for-ancillary-benefits-of-prep-use
#2
Sarit A Golub, Corina Lelutiu-Weinberger, Anthony Surace
BACKGROUND: PrEP stigma (i.e., negative attitudes toward PrEP users) has been widely documented and is considered a significant barrier to implementation. However, few studies have examined PrEP stigma using implicit measures designed to reduce demand characteristics in responding. This study examined implicit PrEP- and HIV-related stigma among gay and bisexual men using geospatial social networking applications (i.e., "hookup apps"). METHODS: Participants were presented with four simulated online profiles (pre-tested for comparability) paired with each of the following characteristics: HIV-negative, HIV-positive, on PrEP, or Substance User...
November 13, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29139333/the-endurance-of-interpersonal-confrontations-as-a-prejudice-reduction-strategy
#3
Kimberly E Chaney, Diana T Sanchez
Previous work has found that individuals who have been confronted for discrimination demonstrate a reduction in explicit prejudice and use fewer stereotypes immediately after the confrontation. Although confronting prejudice has been touted as a tool for prejudice reduction, it is not known how these effects translate over time and what processes might account for their endurance. Across two studies, the present research finds that individuals used significantly fewer negative stereotypes 7 days after confrontation (Study 1) and engaged in behavioral inhibition to stereotypical cues on a probe task 1 week after confrontation...
November 1, 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/29134640/reduced-il-6-levels-and-tumor-associated-phospho-stat3-are-associated-with-reduced-tumor-development-in-a-mouse-model-of-lung-cancer-chemoprevention-with-myo-inositol
#4
Nese Unver, Oliver Delgado, Kirubel Zeleke, Amber Cumpian, Ximing Tang, Mauricio S Caetano, Hong Wang, Hiroyuki Katayama, Hua Yu, Eva Szabo, Ignacio Wistuba, Seyed Javad Moghaddam, Samir Hanash, Edwin J Ostrin
Several promising chemopreventive agents have for lung cancer emerged in preclinical models and in retrospective trials. These agents have been shown to modulate pathways altered in carcinogenesis and reduce markers of carcinogenesis in animal and cell culture models. Cancer-prone transgenic mice with oncogenic Kras expressed in the airway epithelium (Ccsp(Cre/+) ; Kras(LSL-G12D/+) ) were raised on diets compounded with myo-inositol. These animals form lung premalignant lesions in a stereotypical fashion over the ten weeks following weaning...
November 14, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29132332/first-and-second-year-medical-students-identify-and-self-stereotype-more-as-doctors-than-as-students-a-questionnaire-study
#5
Bryan Burford, Harriet E S Rosenthal-Stott
BACKGROUND: The emergence of medical students' professional identity is important. This paper considers this in a snapshot of the early years of undergraduate medical education. From the perspective of social identity theory, it also considers self-stereotyping, the extent to which individuals associate with attributes identified as typical of groups. METHOD: Paper questionnaires were completed by first and second year medical students following teaching sessions at the beginning (October) and end (April) of the academic year...
November 13, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29131692/stigma-and-counter-stigma-frames-cues-and-exemplification-comparing-news-coverage-of-depression-in-the-english-and-spanish-language-media-in-the-u-s
#6
Weirui Wang
A content analysis was conducted to compare news coverage of depression in the English- and Spanish-language media in the United States (N = 355). The study revealed that the English-language media reported stereotypes more frequently than the Spanish-language news media. The presence of all four types of stereotypes (i.e., the mentally ill as violent, suicidal, incompetent, and weak) was associated with the increased use of the stigma frame in the English-language news media, while only the violence stereotype was associated with the increased use of the stigma frame in the Spanish-language news media...
November 13, 2017: Health Communication
https://www.readbyqxmd.com/read/29130824/longitudinal-structural-and-functional-differences-between-proportional-and-poor-motor-recovery-after-stroke
#7
Adrian G Guggisberg, Pierre Nicolo, Leonardo G Cohen, Armin Schnider, Ethan R Buch
BACKGROUND: Evolution of motor function during the first months after stroke is stereotypically bifurcated, consisting of either recovery to about 70% of maximum possible improvement ("proportional recovery, PROP") or in little to no improvement ("poor recovery, POOR"). There is currently no evidence that any rehabilitation treatment will prevent POOR and favor PROP. OBJECTIVE: To perform a longitudinal and multimodal assessment of functional and structural changes in brain organization associated with PROP...
November 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29129534/mechanical-shielding-of-rapidly-growing-cells-buffers-growth-heterogeneity-and-contributes-to-organ-shape-reproducibility
#8
Nathan Hervieux, Satoru Tsugawa, Antoine Fruleux, Mathilde Dumond, Anne-Lise Routier-Kierzkowska, Tamiki Komatsuzaki, Arezki Boudaoud, John C Larkin, Richard S Smith, Chun-Biu Li, Olivier Hamant
A landmark of developmental biology is the production of reproducible shapes, through stereotyped morphogenetic events. At the cell level, growth is often highly heterogeneous, allowing shape diversity to arise. Yet, how can reproducible shapes emerge from such growth heterogeneity? Is growth heterogeneity filtered out? Here, we focus on rapidly growing trichome cells in the Arabidopsis sepal, a reproducible floral organ. We show via computational modeling that rapidly growing cells may distort organ shape...
November 2, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29126896/the-continuous-challenge-of-af-ablation-from-foci-to-rotational-activity
#9
REVIEW
Sanjiv M Narayan, Mohan N Vishwanathan, Christopher A B Kowalewski, Tina Baykaner, Miguel Rodrigo, Junaid A B Zaman, Paul J Wang
Pulmonary vein isolation (PVI) is central to ablation approaches for atrial fibrillation (AF), yet many patients still have arrhythmia recurrence after one or more procedures despite the latest technology for PVI. Ablation of rotational or focal sources for AF, which lie outside the pulmonary veins in many patients, is a practical approach that has been shown to improve success by many groups. Localized sources lie in atrial regions shown mechanistically to sustain AF in optical mapping and clinical studies of human AF, as well as computational and animal studies...
November 7, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29126394/prospective-study-of-autism-phenomenology-and-the-behavioural-phenotype-of-phelan-mcdermid-syndrome-comparison-to-fragile-x-syndrome-down-syndrome-and-idiopathic-autism-spectrum-disorder
#10
Caroline Richards, Laurie Powis, Jo Moss, Christopher Stinton, Lisa Nelson, Christopher Oliver
BACKGROUND: The limited behavioural phenotype literature on Phelan-McDermid syndrome (PMS) indicates atypically high levels of activity, impulsivity and autism spectrum disorder (ASD) behaviours. Divergent profiles of ASD in PMS are also reported, with some studies demonstrating similarities to idiopathic ASD and others indicating an uneven profile of social and communication impairments and repetitive behaviours. An evaluation of the behavioural phenotype of PMS and the prevalence and phenomenology of ASD is warranted, particularly given the causal involvement of the SHANK3 gene in the aetiology of PMS...
November 10, 2017: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/29124785/time-to-address-gender-inequalities-against-female-physicians
#11
Suad Hannawi, Issa Al Salmi
Although the health care system depends heavily on female physicians, it discriminates against women and tends to concentrate female physicians' work in lower status occupations. Gender discrimination has structural, social, and cultural dimensions. Such discrimination is perceived differently by various stakeholders and the public. In addition, there is reluctance to publicly acknowledge gender discrimination, especially in the culturally conservative Middle East region. Gender discrimination leads to underrepresentation of female physicians in leadership roles and certain specialties and hence leads to less attention and understanding of the working conditions of female physicians and their roles in the health care system...
November 10, 2017: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29122641/regularities-in-zebra-finch-song-beyond-the-repeated-motif
#12
Julia Hyland Bruno, Ofer Tchernichovski
The proliferation of birdsong research into the neural mechanisms of vocal learning is indebted to the remarkable stereotypy of the zebra finch's song motif. Motifs are composed of several copied syllables, which birds learn to produce in a fixed order. But at a higher level of organization-the bout-zebra finch song is no longer stereotyped. Song bouts include several repetitions of the motif, which are often linked by a variable number of short "connector" vocalizations. In this conceptual methods paper, we show that combinatorial analysis alone yields an incomplete description of this bout-level structure...
November 6, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/29120669/schizophrenia-as-a-psychosomatic-illness-an-interdisciplinary-approach-between-lacanian-psychoanalysis-and-the-neurosciences
#13
Yorgos Dimitriadis
According to Lacan's theory of schizophrenia (as well as other delirious forms of psychosis), under certain conditions the signifying function breaks down, thus turning the schizophrenic individual's world into one in which a number of events become enigmatic and signal him or her. The schizophrenic individual tries to deal with these signs that besiege him or her either by means of an interpretative attitude (a stable delusional mood) or by apathy. These two types of responses correspond with the stereotypical (and mood) processes by which the schizophrenic individual attempts to avoid the distress provoked by the enigmatic desire of the Other, while simultaneously corresponding with psychosomatic processes of the brain organ...
November 9, 2017: Bulletin of the Menninger Clinic
https://www.readbyqxmd.com/read/29120307/preliminary-investigation-of-the-stbbi-stigma-scale-description-and-pilot-results
#14
Anne C Wagner, Rachel MacLean
OBJECTIVES: Sexually transmitted and blood-borne infections (STBBIs) are associated with stigmatizing attitudes and beliefs, which can affect the quality of and access to health care, as well as mental health and quality of life. The current study describes the adaptation from an HIV-related stigma scale and pilot testing of a new STBBI Stigma Scale, assessing the stigmatizing attitudes and beliefs of health and social service providers in Canada. METHODS: 144 health and social service providers from across Canada completed the newly adapted scale assessing stigma associated with HIV, hepatitis C, other viral STBBIs and bacterial STBBIs, as well as demographic information, a scale of social desirability and measures of convergent and divergent validity...
November 9, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/29120126/changes-in-nursing-students%C3%A2-attitudes-towards-nursing-during-undergraduate-study
#15
Snježana Čukljek, Vesna Jureša, Cecilija Grgas Bile, Biserka Režek
The aim of this study was to determine the attitudes of nursing students towards nursing, and changes in their attitudes during the study. A quantitative study with pre-post survey was conducted among nursing students enrolled in first study year in the academic year 2012/2013 (N=115) and third study year in the academic year 2014/2015 (N=106). Students voluntarily and anonymously completed a questionnaire consisting of demographic information and the Nursing Image Questionnaire, which includes 30 items that assess how an individual looks at the roles and tasks, values, social stereotypes of nursing, professionalism and performance of nurses...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29116908/small-change-makes-a-big-splash-the-role-of-working-self-concept-in-the-effects-of-stereotype-threat-on-memory
#16
Pei Liu, Fengqing Zhao, Baoshan Zhang, Qingxiu Dang
Assuming that the principle of an active-self account holds true in real life, priming certain constructs could selectively activate a working self-concept, which in turn guides behavior. The current study involved two experiments that examined the relationships between stereotypic identity, working self-concept, and memory performance in older adults. Specifically, Study 1 tested whether a stereotype threat can affect older adults' working self-concept and memory performance. A modified Stroop color naming task and a separate recognition task showed that a stereotype threat prime altered the activation of the working self-concept and deteriorated the older adults' memory performance...
October 3, 2017: Journal of Psychology
https://www.readbyqxmd.com/read/29116905/epistemic-injustice-in-dementia-and-autism-patient-organizations-an-empirical-analysis
#17
Karin Jongsma, Elisabeth Spaeth, Silke Schicktanz
Patient organizations (POs) represent patient collectives in health care policy. The inclusion of people with a 'neuro-psychiatric' condition poses a particular challenge for the organizational processes and political representation of such collectives. In recent years, new POs (POs of) have been established in the field of autism spectrum disorder and dementia that advocate a different agenda and have a different organizational structure than traditional POs (POs for). The divide between these two types of POs indicates a different standpoint with regard to who should be included on an organizational level, which voices are accepted and who should represent these voices on the political level...
November 8, 2017: AJOB Empirical Bioethics
https://www.readbyqxmd.com/read/29109240/deficiency-of-the-thyroid-hormone-transporter-mct8-in-neural-progenitors-impairs-cellular-processes-crucial-for-early-corticogenesis
#18
Pieter Vancamp, Marie-Anne Deprez, Michiel Remmerie, Veerle M Darras
Thyroid hormones (THs) are essential for establishing layered brain structures, a process called corticogenesis, by acting on transcriptional activity of numerous genes. In humans, deficiency of the monocarboxylate transporter 8 (MCT8), involved in cellular uptake of THs prior to their action, results in severe neurological abnormalities, known as the Allan-Herndon-Dudley Syndrome. While the brain lesions predominantly originate prenatally, it remains unclear how and when exactly MCT8 dysfunction affects cellular processes crucial for corticogenesis...
November 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29107320/walking-my-way-walker-gender-and-display-format-confounds-the-perception-of-specific-emotions
#19
Shaun Halovic, Christian Kroos
Previous evidence has shown that males and females display different gait kinematics which may influence the perception of emotions displayed through the same walking gait. We therefore investigated the influence of walker gender on the perception of happiness, sadness, anger and fear displayed through walking movements. Full-light (FL), point-light (PL) and synthetically modelled point-light walkers (SW) of both genders were shown to perceivers over three experiments. Additionally, gender ambiguous synthetic walkers were shown to control for the influence of form, gender stereotypes and idiosyncratic gait movements on emotional gait perception...
October 26, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29104697/novel-surgical-approach-in-cutaneous-melanoma-patients-daring-ideas-are-like-chessmen-moved-forward-they-may-be-beaten-but-they-may-start-a-winning-game
#20
Georgi Tchernev
For the first time, but again, we propose the idea of a one-step melanoma surgery as a "golden, unified standard" that should be at least discussed and, possibly accepted shortly as the "gold standard" for the treatment of patients with skin melanomas. Critical points or comments have been made to the current melanoma's treatment approach, which has been "transcendently followed" for years and which, according to some colleagues, is not logically justified. This approach needs serious changes, the only goal of which is to achieve a better outlook for the patients...
October 15, 2017: Open Access Macedonian Journal of Medical Sciences
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