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https://www.readbyqxmd.com/read/27915361/neuroscience-literacy-brain-tells-as-signals-of-brain-dysfunction-affecting-daily-life
#1
Charlotte B Royeen, James R Brašić, Leah Dvorak, Casey Provoziak-O'Brien, Chetna Sethi, S Omar Ahmad
The structures and circuits of the central and the peripheral nervous systems provide the basis for thinking, speaking, experiencing sensations, and performing perceptual and motor activities in daily life. Healthy people experience normal functioning without giving brain functions a second thought, while dysfunction of the neural circuits may lead to marked impairments in cognition, communication, sensory awareness, and performing perceptual and motor tasks. Neuroscience literacy provides the knowledge to associate the deficits observed in patients with the underlying deficits in the structures and circuits of the nervous system...
2016: Journal of Allied Health
https://www.readbyqxmd.com/read/27914936/public-health-and-public-trust-survey-evidence-from-the-ebola-virus-disease-epidemic-in-liberia
#2
Robert A Blair, Benjamin S Morse, Lily L Tsai
Trust in government has long been viewed as an important determinant of citizens' compliance with public health policies, especially in times of crisis. Yet evidence on this relationship remains scarce, particularly in the developing world. We use results from a representative survey conducted during the 2014-15 Ebola Virus Disease (EVD) epidemic in Monrovia, Liberia to assess the relationship between trust in government and compliance with EVD control interventions. We find that respondents who expressed low trust in government were much less likely to take precautions against EVD in their homes, or to abide by government-mandated social distancing mechanisms designed to contain the spread of the virus...
November 14, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27914116/so-it-is-so-it-shall-be-group-regularities-license-children-s-prescriptive-judgments
#3
Steven O Roberts, Susan A Gelman, Arnold K Ho
When do descriptive regularities (what characteristics individuals have) become prescriptive norms (what characteristics individuals should have)? We examined children's (4-13 years) and adults' use of group regularities to make prescriptive judgments, employing novel groups (Hibbles and Glerks) that engaged in morally neutral behaviors (e.g., eating different kinds of berries). Participants were introduced to conforming or non-conforming individuals (e.g., a Hibble who ate berries more typical of a Glerk)...
December 3, 2016: Cognitive Science
https://www.readbyqxmd.com/read/27911289/the-brain-s-structural-connectome-mediates-the-relationship-between-regional-neuroimaging-biomarkers-in%C3%A2-alzheimer-s-disease
#4
Sneha Pandya, Amy Kuceyeski, Ashish Raj
Alzheimer's disease (AD), one of the most common causes of dementia in adults, is a progressive neurodegenerative disorder exhibiting well-defined neuropathological hallmarks. It is known that disease pathology involves misfolded amyloid-β (Aβ) and tau proteins, and exhibits a relatively stereotyped progression over decades. The relationship between AD neuropathological hallmarks (Aβ, hypometabolism, and tau proteins) and imaging biomarkers (MRI, AV-45/FDG-PET) is not fully understood. In addition, biomarker pathologies are oftentimes discordant, wherein it may show varying levels of abnormality across brain regions...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27905391/-the-stabilometric-and-clinical-characteristics-in-patients-with-the-consequences-of-stroke-during-the-complex-rehabilitation
#5
V A Bronnikov, V B Smychek, Yu A Mavlikaeva, K A Sklyannaya, Yu I Kravtsov, A O Gorbacheva, A V Vil'deman
AIM: To perform the complex stabilometric and clinical assessment of movement disorders in post-stroke patients. MATERIAL AND METHODS: Sixty-three patients in the late recovery period of stroke underwent the complex rehabilitation in the hospital. RESULTS: Based on the dynamics of statokinesiogram area and shift of the center of pressure, four variants of stabilometric changes with different baseline parameters of patient's motor activity were determined...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27904140/restrictions-in-the-t-cell-repertoire-of-chronic-lymphocytic-leukemia-high-throughput-immunoprofiling-supports-selection-by-shared-antigenic-elements
#6
A Vardi, E Vlachonikola, M Karypidou, E Stalika, V Bikos, K Gemenetzi, C Maramis, A Siorenta, A Anagnostopoulos, S Pospisilova, N Maglaveras, I Chouvarda, K Stamatopoulos, A Hadzidimitriou
Immunoglobulin (IG) gene repertoire restrictions strongly support antigen selection in the pathogenesis of chronic lymphocytic leukemia (CLL). Given the emerging multifarious interactions between CLL and bystander T cells, we sought to determine whether antigen(s) are also selecting T cells in CLL. We performed a large-scale, next-generation sequencing (NGS) study of the T-cell repertoire, focusing on major stereotyped subsets representing CLL subgroups with undisputed antigenic drive, but also included patients carrying non-subset IG rearrangements to seek for T-cell immunogenetic signatures ubiquitous in CLL...
December 1, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27903734/deviations-from-critical-dynamics-in-interictal-epileptiform-activity
#7
Oshrit Arviv, Mordekhay Medvedovsky, Liron Sheintuch, Abraham Goldstein, Oren Shriki
: The framework of criticality provides a unifying perspective on neuronal dynamics from in vitro cortical cultures to functioning human brains. Recent findings suggest that a healthy cortex displays critical dynamics, giving rise to scale-free spatiotemporal cascades of activity, termed neuronal avalanches. Pharmacological manipulations of the excitation-inhibition balance (EIB) in cortical cultures were previously shown to result in deviations from criticality and from the power law scaling of avalanche size distribution...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27903136/outcomes-of-a-psychoeducational-intervention-to-reduce-internalized-stigma-among-psychosocial-rehabilitation-clients
#8
Alicia Lucksted, Amy L Drapalski, Clayton H Brown, Camille Wilson, Melanie Charlotte, Audrina Mullane, Li Juan Fang
OBJECTIVE: This community-based randomized controlled trial was carried out to test the Ending Self-Stigma (ESS) psychoeducational intervention, which is designed to help adults with serious mental illnesses reduce internalization of mental illness stigma and its effects. METHODS: A total of 268 adults from five different mental health programs in Maryland took part. After baseline interview, consenting participants were randomly assigned to the nine-week ESS intervention or a minimally enhanced treatment-as-usual control condition...
December 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27899442/early-generated-b1-b-cells-with-restricted-bcrs-become-chronic-lymphocytic-leukemia-with-continued-c-myc-and-low-bmf-expression
#9
Kyoko Hayakawa, Anthony M Formica, Joni Brill-Dashoff, Susan A Shinton, Daiju Ichikawa, Yan Zhou, Herbert C Morse, Richard R Hardy
In mice, generation of autoreactive CD5(+) B cells occurs as a consequence of BCR signaling induced by (self)-ligand exposure from fetal/neonatal B-1 B cell development. A fraction of these cells self-renew and persist as a minor B1 B cell subset throughout life. Here, we show that transfer of early generated B1 B cells from Eμ-TCL1 transgenic mice resulted in chronic lymphocytic leukemia (CLL) with a biased repertoire, including stereotyped BCRs. Thus, B1 B cells bearing restricted BCRs can become CLL during aging...
November 29, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27899087/paradoxical-physiological-responses-to-propranolol-in-a-rett-syndrome-patient-a-case-report
#10
P J Santosh, L Bell, K Lievesley, J Singh, F Fiori
BACKGROUND: Rett Syndrome (RTT), caused by a loss-of-function in the epigenetic modulator: X-linked methyl-CpG binding protein 2 (MeCP2), is a pervasive neurological disorder characterized by compromised brain functions, anxiety, severe mental retardation, language and learning disabilities, repetitive stereotyped hand movements and developmental regression. An imbalance in the sympathetic and the parasympathetic nervous system (dysautonomia) and the resulting autonomic storms is a frequent occurrence in patients with RTT...
November 29, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27895886/back-to-the-ussr-how-colors-might-shape-the-political-perception-of-east-versus-west
#11
Fabian Gebauer, Marius H Raab, Claus-Christian Carbon
People typically process information to confirm their prior held attitudes and stereotypes. As the political relations between NATO and Russia have distinctively drifted apart in recent years, we were interested in how far old-established color depictions referring to the Cold War's demarcations (USSR = red; NATO = blue) might reinforce people's political perception of an East versus West antagonism nowadays. Participants received a fabricated news article in which both world powers were either depicted on a map as Russia = red and NATO = blue or vice versa (Study 1)...
November 2016: I-Perception
https://www.readbyqxmd.com/read/27893905/critical-care-interprofessional-education-exploring-conflict-and-power-lessons-learned
#12
Mary Louanne Friend, Richard D Friend, Cassandra Ford, Patrick J Ewell
BACKGROUND: The purpose of this mixed-methods study was to evaluate the effects of an innovative critical care interprofessional education intervention on prelicensure nursing and medical students at a large public university. The class provided opportunities for students to (a) explore stereotypes about each respective profession, (b) examine the occurrence and effects of interprofessional conflict in high-acuity areas, and (c) explore conflict resolution techniques while learning how to perform critical care procedures as a team...
December 1, 2016: Journal of Nursing Education
https://www.readbyqxmd.com/read/27893260/brain-drain-an-examination-of-stereotype-threat-effects-during-training-on-knowledge-acquisition-and-organizational-effectiveness
#13
James A Grand
Stereotype threat describes a situation in which individuals are faced with the risk of upholding a negative stereotype about their subgroup based on their actions. Empirical work in this area has primarily examined the impact of negative stereotypes on performance for threatened individuals. However, this body of research seldom acknowledges that performance is a function of learning-which may also be impaired by pervasive group stereotypes. This study presents evidence from a 3-day self-guided training program demonstrating that stereotype threat impairs acquisition of cognitive learning outcomes for females facing a negative group stereotype...
November 28, 2016: Journal of Applied Psychology
https://www.readbyqxmd.com/read/27889070/prenatal-ethanol-exposure-modifies-locomotor-activity-and-induces-selective-changes-in-met-enk-expression-in-adolescent-rats
#14
P Abate, A C Reyes-Guzmán, K Hernández-Fonseca, M Méndez
Several studies suggest that prenatal ethanol exposure (PEE) facilitates ethanol intake. Opioid peptides play a main role in ethanol reinforcement during infancy and adulthood. However, PEE effects upon motor responsiveness elicited by an ethanol challenge and the participation of opioids in these actions remain to be understood. This work assessed the susceptibility of adolescent rats to prenatal and/or postnatal ethanol exposure in terms of behavioral responses, as well as alcohol effects on Met-enk expression in brain areas related to drug reinforcement...
November 22, 2016: Neuropeptides
https://www.readbyqxmd.com/read/27888954/the-effect-of-internalized-stigma-on-the-self-esteem-in-patients-with-schizophrenia
#15
Sibel Asi Karakaş, Ayşe Okanlı, Emine Yılmaz
AIM: This study has been conducted to determine the relationship between internalized stigma and self-esteem in patients with schizophrenia. MATERIALS AND METHODS: This study was conducted using 60 patients with schizophrenia who were diagnosed as schizophrenic according to the DSM-IV diagnostic criteria in the psychiatric clinics of hospitals in Erzurum. The data were collected using the "Questionnaire on Internalized Stigma of Mental Illness Scale" (ISMI) that determines the socio-demographic characteristics of patients, and the "Short Form of Self-Esteem Scale" (SF-SES)...
December 2016: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/27887721/comparative-multimodal-meta-analysis-of-structural-and-functional-brain-abnormalities-in-autism-spectrum-disorder-and-obsessive-compulsive-disorder
#16
Christina O Carlisi, Luke J Norman, Steve S Lukito, Joaquim Radua, David Mataix-Cols, Katya Rubia
BACKGROUND: Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) share inhibitory control deficits possibly underlying poor control over stereotyped and repetitive g., v/r/ dACC /MPFC); and (iv) to indicate a pathway (e.g., if this is a pathway: bilateral putamen/caudate/nucleus accumbens / pallidum /amygdala/insula). BPS style does not allow virgules to be used to represent expressions of duality or alternatives. Please express these as and/or, and, or or . BPS style does not allow virgules to be used to represent a compound modifier such as "rostral/ dorsomedial ," which should be changed to hyphen(s), such as rostral- dorsomedial ...
October 13, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27885983/klp10a-a-stem-cell-centrosome-enriched-kinesin-balances-asymmetries-in-drosophila-male-germline-stem-cell-division
#17
Cuie Chen, Mayu Inaba, Zsolt G Venkei, Yukiko M Yamashita
Asymmetric stem cell division is often accompanied by stereotypical inheritance of the mother and daughter centrosomes. However, it remains unknown whether and how stem cell centrosomes are uniquely regulated and how this regulation may contribute to stem cell fate. Here we identify Klp10A, a microtubule-depolymerizing kinesin of the kinesin-13 family, as the first protein enriched in the stem cell centrosome in Drosophila male germline stem cells (GSCs). Depletion of klp10A results in abnormal elongation of the mother centrosomes in GSCs, suggesting the existence of a stem cell-specific centrosome regulation program...
November 25, 2016: ELife
https://www.readbyqxmd.com/read/27885971/-a-magical-little-pill-that-will-relieve-you-of-your-womanly-issues-what-young-women-say-about-menstrual-suppression
#18
Colleen McMillan, Amanda Jenkins
Perceptions of menstruation by media discourses portray this bodily function to be messy, inconvenient, and as an unnecessary phenomenon to be controlled or possibly eliminated. Commercials shown on YouTube targeted toward young women suggest that having a monthly period is not healthy and a lifestyle that is menses free is both pharmacologically available and recommended in order to live a fuller life. We explored the meanings attached to online menstrual suppression commercials with 10 women aged between 18 and 25...
2016: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/27885069/exploring-family-stigma-among-caregivers-of-persons-with-alzheimer-s-disease-the-experiences-of-israeli-arab-caregivers
#19
Hanan Abojabel, Perla Werner
Providing care to persons with Alzheimer's disease poses challenges for spouses and adult children, including experiencing stigmatic beliefs towards themselves-i.e., family stigma. Drawing on the frameworks of ethnicity and stigma and ethnicity and dementia, the current study explored stigmatic experiences among Israeli Arab family caregivers of a person with Alzheimer's disease. Three focus groups with 20 caregivers (adult children and spouses) of persons with Alzheimer's disease were conducted. Data were analyzed using theory-led thematic analysis...
November 24, 2016: Dementia
https://www.readbyqxmd.com/read/27884450/rhythmic-movement-disorder-in-childhood-an-integrative-review
#20
REVIEW
Amy R M Gwyther, Arthur S Walters, Catherine M Hill
Rhythmic movement disorder consists of repetitive stereotypic movements, such as head banging or body rocking, that recur every second or so and may last from a few minutes to hours, usually prior to sleep onset. This review of childhood rhythmic movement disorder highlights the lack of systematic research into core aspects of the condition, relying heavily on small case series or case reports. Interpretation is further limited by almost universal failure to confirm the core diagnostic criteria (C) of the International classification of sleep disorders (III), namely that the rhythmic movements should have clinical consequences...
August 26, 2016: Sleep Medicine Reviews
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