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https://www.readbyqxmd.com/read/28523301/large-variability-of-the-activity-and-chronicity-indexes-within-and-between-histological-classes-of-lupus-nephritis
#1
Tudor Azoicăi, Ioana Mădălina Belibou, Ludmila Lozneanu, Simona Eliza Giuşcă, Elena Cojocaru, Irina Draga Căruntu
Systemic lupus erythematosus (SLE) is characterized by a multifaceted pathogenesis and a heterogeneous clinical expression. The kidney involvement is almost unavoidable in all forms of SLE with chronic evolution, 75% of patients developing renal lesions defined as lupus nephritis (LN) - a glomerulonephritis with an extremely diverse lesion spectrum. The present study aimed to reevaluate a series of cases diagnosed as LN, focusing on the histological features in correlation with the level of activity and chronicity...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28515366/experimental-lupus-is-aggravated-in-mouse-strains-with-impaired-induction-of-neutrophil-extracellular-traps
#2
Deborah Kienhöfer, Jonas Hahn, Julia Stoof, Janka Zsófia Csepregi, Christiane Reinwald, Vilma Urbonaviciute, Caroline Johnsson, Christian Maueröder, Malgorzata J Podolska, Mona H Biermann, Moritz Leppkes, Thomas Harrer, Malin Hultqvist, Peter Olofsson, Luis E Munoz, Attila Mocsai, Martin Herrmann, Georg Schett, Rikard Holmdahl, Markus H Hoffmann
Many effector mechanisms of neutrophils have been implicated in the pathogenesis of systemic lupus erythematosus (SLE). Neutrophil extracellular traps (NETs) have been assigned a particularly detrimental role. Here we investigated the functional impact of neutrophils and NETs on a mouse model of lupus triggered by intraperitoneal injection of the cell death-inducing alkane pristane. Pristane-induced lupus (PIL) was aggravated in 2 mouse strains with impaired induction of NET formation, i.e., NOX2-deficient (Ncf1-mutated) and peptidyl arginine deiminase 4-deficient (PAD4-deficient) mice, as seen from elevated levels of antinuclear autoantibodies (ANAs) and exacerbated glomerulonephritis...
May 18, 2017: JCI Insight
https://www.readbyqxmd.com/read/28505391/establishment-of-a-novel-quantum-dots-encoded-microbead-based-flow-cytometric-method-for-quantification-of-soluble-fc%C3%AE%C2%B5ri%C3%AE-in-serum
#3
Kun Lin, Wen Xu, Wanwan Li, Yuankui Leng, Weijie Wu, Xia Peng, Yuting Liang, Li Li
The soluble form of the transmembrane glycoprotein, FcεRIα which corresponds to the high-affinity receptor for IgE, is found in serum. Growing evidence suggests the pathogenic role of IgE and FcεRI in systemic lupus erythematosus (SLE). The goal of this study is to develop a sensitive and standardized cytometric assay for quantification of sFcεRIα. A membrane emulsification technique was utilized to incorporate CuInS2 /ZnS quantum dots and Fe3 O4 nanoparticles into poly (styrene-co-maleic anhydride) microbeads...
May 15, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28502134/thyroid-dysfunctions-in-a-sample-of-egyptian-children-and-adolescents-with-systemic-lupus-erythematosus-relation-to-disease-activity-and-duration
#4
Hend H Abd-Elnabi, Mohamed A El-Gamasy, Maher A Abd-Elhafez
Systemic lupus erythematosus (SLE) is a chronic, autoimmune, inflammatory disease affects any organ of the body, including the thyroid gland. Both hypothyroidism and hyperthyroidism have been found in SLE patients more frequently than general population. The aim of this study was to evaluate the frequency of autoimmune thyroid dysfunctions in juvenile SLE and its relation to disease activity and duration. A prospective case-control study was carried on 40 children with juvenile SLE and 30 healthy as controls, all were subjected to measurement of serum TSH, Free T3, Free T4 and anti-TG by ELISA...
June 2016: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/28483541/clinical-spectrum-and-therapeutic-management-of-systemic-lupus-erythematosus-associated-macrophage-activation-syndrome-a-study-of-103-episodes-in-89-adult-patients
#5
REVIEW
Pierre-Edouard Gavand, Ilaria Serio, Laurent Arnaud, Nathalie Costedoat-Chalumeau, Julien Carvelli, Antoine Dossier, Olivier Hinschberger, Luc Mouthon, Véronique Le Guern, Anne-Sophie Korganow, Vincent Poindron, Clément Gourguechon, Christian Lavigne, François Maurier, Guylaine Labro, Marie Heymonet, Matthieu Artifoni, Amélie Brabant Viau, Cristophe Deligny, Thomas Sene, Louis Terriou, Jean Sibilia, Alexis Mathian, Coralie Bloch-Queyrat, Claire Larroche, Zahir Amoura, Thierry Martin
OBJECTIVES: Macrophage activation syndrome (MAS) is a life-threatening hyperinflammatory syndrome that can occur during systemic lupus erythematosus (SLE). Data on MAS in adult SLE patients are very limited. The aim of this study is to describe the clinical characteristics, laboratory findings, treatments, and outcomes of a large series of SLE-associated MAS. METHODS: We conducted a retrospective study that included 103 episodes of MAS in 89 adult patients with SLE...
May 5, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28478733/the-psychometric-properties-of-the-evaluation-of-daily-activity-questionnaire-in-seven-musculoskeletal-conditions
#6
Alison Hammond, Yeliz Prior, Mike Colin Horton, Alan Tennant, Sarah Tyson
PURPOSE: The purpose of this study is to psychometrically test the Evaluation of Daily Activity Questionnaire in seven musculoskeletal conditions. MATERIALS AND METHODS: One thousand and two hundred people with ankylosing spondylitis; osteoarthritis; systemic lupus erythematosus; systemic sclerosis; chronic pain; chronic upper limb disorders; or Primary Sjögren's syndrome completed the Evaluation of Daily Activity Questionnaire, Health Assessment Questionnaire and Short-Form Health Survey v2...
May 8, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28476075/drugs-for-discoid-lupus-erythematosus
#7
REVIEW
Sue Jessop, David A Whitelaw, Matthew J Grainge, Prativa Jayasekera
BACKGROUND: Discoid lupus erythematosus (DLE) is a chronic form of cutaneous lupus, which can cause scarring. Many drugs have been used to treat this disease and some (such as thalidomide, cyclophosphamide and azathioprine) are potentially toxic. This is an update of a Cochrane Review first published in 2000, and previously updated in 2009. We wanted to update the review to assess whether any new information was available to treat DLE, as we were still unsure of the effectiveness of available drugs and how to select the most appropriate treatment for an individual with DLE...
May 5, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28472610/nature-functions-and-clinical-implications-of-igg4-autoantibodies-in-systemic-lupus-erythematosus-and-rheumatoid-arthritis
#8
Qingjun Pan, Qiaofen Lan, Yanxia Peng, Jun Cai, Jian Zheng, Carol Dickerson, Haiyan Xiao, Hua-Feng Liu
Protective autoantibodies in homeostasis, clinical relevance, and therapeutic potential have gained wide attention. Recent studies showed that IgG4 autoantibodies play crucial roles in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). In one aspect, IgG4 autoantibodies can bind autoantigens in competition with other classes of immunoglobulins (e.g., IgG1, IgG2a) to form non-inflammatory immune-complexes (ICs), which have a limited ability to induce immune responses because of the low affinity of IgG4 for both Fc receptors and the C1 complement molecule, resulting in reduced inflammatory response in SLE and RA...
March 2017: Discovery Medicine
https://www.readbyqxmd.com/read/28471597/women-s-issues-in-antiphospholipid-syndrome
#9
Emmanouil Papadakis, Anastasia Banti, Anna Kioumi
Antiphospholipid syndrome (APS) is an autoimmune systemic disease characterized by vascular thrombosis (arterial or venous) and/or pregnancy complications associated with the occurrence of autoantibodies, specifically lupus anticoagulant, anticardiolipin antibodies, and/or anti-β2 glycoprotein-I antibodies confirmed at least twice over a 12 week period according to the 2006 Sydney criteria. Antiphospholipid antibodies are encountered  in the general population with a reported prevalence of 1% to 5%  However, APS is far more infrequent with a prevalence of 40-50/100,000 persons and an incidence of about 5 new patients/100,000 persons...
September 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28460654/myocarditis-flail-tricuspid-valve-and-normal-rhythm-an-exceptional-form-of-neonatal-cardiac-lupus
#10
María-Teresa González-López, Ramón Pérez-Caballero-Martínez, Juan-Miguel Gil-Jaurena
Neonatal cardiac lupus is a rare, passively acquired autoimmune disease. We report a case of in utero myocarditis, confirmed postnatally, with papillary muscle rupture and severe tricuspid regurgitation after birth in the absence of conduction disturbances. Tricuspid repair was successfully performed with polytetrafluoroethylene neochordae. In this article, we discuss the pathophysiology, medical and surgical management, and implications at follow-up in this unique scenario.
May 2, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28457424/what-can-we-do-when-all-collapses-fatal-outcome-of-collapsing-glomerulopathy-and-systemic-lupus-erythematosus-with-diffuse-alveolar-hemorrhage-case-report
#11
H Pinto, R Leal, L Rodrigues, L Santos, C Romãozinho, F Macário, R Alves, J Pratas, V Sousa, C Marinho, L Prado E Castro, F Costa, M Campos, A Mota, A Figueiredo
INTRODUCTION: Collapsing glomerulopathy (CG) is a rare form of glomerular injury. Although commonly associated with human immunodeficiency virus (HIV) infection, it can occur in association with systemic lupus erythematosus (SLE). CASE REPORT: We present the case of a 50-year-old man, with chronic kidney disease secondary to focal and segmental glomerulosclerosis, who received a cadaveric kidney transplant in 2007. There were no relevant intercurrences until May 2015, when he presented with nephrotic range proteinuria (± 4 g/d)...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28432050/prevalence-of-remission-and-its-effect-on-damage-and-quality-of-life-in-chinese-patients-with-systemic-lupus-erythematosus
#12
Chi Chiu Mok, Ling Yin Ho, Sau Mei Tse, Kar Li Chan
OBJECTIVES: To study the prevalence of remission and its effect on damage and quality of life (QOL) in Chinese patients with systemic lupus erythematosus (SLE). METHODS: Patients who fulfilled≥4 American College of Rheumatology criteria for SLE were identified. Their remission status at last clinic visits was determined by the European consensus criteria (complete/clinical remission ± immunosuppressive drugs). The increase in SLE damage index (SDI) in the preceding 5 years was compared between patients who were and were not in remission for ≥5 years...
April 21, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28424695/b-cell-tolerance-to-deiminated-histones-in-balb-c-c57bl-6-and-autoimmune-prone-mouse-strains
#13
Nishant Dwivedi, Annica Hedberg, Ying Yi Zheng, Indira Neeli, Minoru Satoh, Laurence Morel, Ole Petter Rekvig, Marko Radic
Deimination, a posttranslational modification of arginine to citrulline carried out by peptidylarginine deiminases, may compromise tolerance of self-antigens. Patients with connective tissue autoimmunity, particularly rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), or Felty's syndrome, present with autoantibodies to deiminated histones (dH), which thus form a category of antibodies to citrullinated protein antigens (ACPA). In general, ACPA are a sensitive diagnostic for RA and may form in response to the release of nuclear chromatin (DNA plus dH) from granulocytes, usually referred to as neutrophil extracellular traps...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28420059/neuropsychiatric-symptoms-in-systemic-lupus-erythematosus-impact-on-quality-of-life
#14
R C Monahan, L J J Beaart-van de Voorde, G M Steup-Beekman, C Magro-Checa, T W J Huizinga, J Hoekman, A A Kaptein
Objective Assess quality of life in patients with systemic lupus erythematosus (SLE) presenting with neuropsychiatric symptoms (neuropsychiatric SLE, NPSLE). Methods Quality of life was assessed using the Short-Form 36 item Health Survey (SF-36) in patients visiting the Leiden NPSLE clinic at baseline and at follow-up. SF-36 subscales and summary scores were calculated and compared with quality of life of the general Dutch population and patients with other chronic diseases. Results At baseline, quality of life was assessed in 248 SLE patients, of whom 98 had NPSLE (39...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28414021/elliptical-broken-line-method-for-calculating-capillary-density-in-nailfold-capillaroscopy-proposal-and-evaluation
#15
Abdolamir Karbalaie, Farhad Abtahi, Alimohammad Fatemi, Mahnaz Etehadtavakol, Zahra Emrani, Björn-Erik Erlandsson
Nailfold capillaroscopy is a practical method for identifying and obtaining morphological changes in capillaries which might reveal relevant information about diseases and health. Capillaroscopy is harmless, and seems simple and repeatable. However, there is lack of established guidelines and instructions for acquisition as well as the interpretation of the obtained images; which might lead to various ambiguities. In addition, assessment and interpretation of the acquired images are very subjective. In an attempt to overcome some of these problems, in this study a new modified technique for assessment of nailfold capillary density is introduced...
April 14, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28412708/validity-and-reliability-of-patient-reported-outcomes-measurement-information-system-computerized-adaptive-tests-in-systemic-lupus-erythematosus
#16
Shanthini Kasturi, Jackie Szymonifka, Jayme C Burket, Jessica R Berman, Kyriakos A Kirou, Alana B Levine, Lisa R Sammaritano, Lisa A Mandl
OBJECTIVE: The aims of this study were to assess the construct validity and the test-retest reliability of Patient Reported Outcomes Measurement Information System (PROMIS) computerized adaptive tests (CAT) in patients with systemic lupus erythematosus (SLE). METHODS: Adults with SLE completed the Medical Outcomes Study Short Form-36, LupusQoL-US version ("legacy instruments"), and 14 selected PROMIS CAT. Using Spearman correlations, PROMIS CAT were compared with similar domains measured with legacy instruments...
April 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28411133/clinical-significance-of-fibromyalgia-syndrome-in-different-rheumatic-diseases-relation-to-disease-activity-and-quality-of-life
#17
Sarah El-Rabbat M, Nermeen K Mahmoud, Tamer A Gheita
OBJECTIVE: To describe the frequencies of fibromyalgia syndrome (FMS) in various rheumatic diseases; rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and Behçets disease (BD) patients and to study the relation to clinical manifestations and quality of life (QoL). PATIENTS AND METHODS: 160 patients (50 RA, 50 SLE, 30 SSc and 30 BD) and matched corresponding healthy controls were included. Disease activity was assessed using disease activity score in 28 joints (DAS28) for RA, SLE Disease Activity index (SLEDAI), modified Rodnan skin score for SSc and BD Current Activity Form (BDCAF)...
April 11, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28406761/the-performance-of-different-classification-criteria-in-paediatric-beh%C3%A3-et-s-disease
#18
Ezgi Deniz Batu, Hafize Emine Sönmez, Betul Sözeri, Yonatan Butbul Aviel, Yelda Bilginer, Seza Özen
OBJECTIVES: Behçet's disease (BD) is a variable vessel vasculitis. The most widely used classification criteria for adults is the International Behçet's Study Group (ISG) criteria. Recently, the paediatric BD (PEDBD) classification criteria has been developed for children. For disease activity, there are mainly two severity scores; the Iranian BD dynamic activity measure (IBDDAM) and BD current activity form (BDCAF). We tested the performances of PEDBD and ISG criteria and the correlation between severity scores and physician global assessment (PGA) in children with BD...
April 5, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28394225/outcomes-of-neuropsychiatric-events-in-systemic-lupus-erythematosus-based-on-clinical-phenotypes-prospective-data-from-the-leiden-np-sle-cohort
#19
C Magro-Checa, L J J Beaart-van de Voorde, H A M Middelkoop, M L Dane, N J van der Wee, M A van Buchem, T W J Huizinga, G M Steup-Beekman
Objective The objective of this study was to assess whether clinical and patient's reported outcomes are associated with a different pathophysiological origin of neuropsychiatric events presenting in systemic lupus erythematosus. Methods A total of 232 neuropsychiatric events presenting in 131 systemic lupus erythematosus patients were included. Neuropsychiatric systemic lupus erythematosus diagnosis was established per event by multidisciplinary evaluation. All neuropsychiatric events were divided according to a suspected underlying pathophysiological process into one of the following: non-neuropsychiatric systemic lupus erythematosus related, inflammatory and ischaemic neuropsychiatric systemic lupus erythematosus...
April 2017: Lupus
https://www.readbyqxmd.com/read/28394223/gestational-outcomes-in-patients-with-neuropsychiatric-systemic-lupus-erythematosus
#20
G R de Jesus, B C Rodrigues, M I Lacerda, F C Dos Santos, N R de Jesus, E M Klumb, R A Levy
This study analyzed maternal and fetal outcomes of pregnancies of neuropsychiatric systemic lupus erythematosus patients followed in a reference unit. This retrospective cohort study included 26 pregnancies of patients seen between 2011 and 2015 included with history and/or active neuropsychiatric systemic lupus erythematosus among 135 pregnancies. Three patients had active neuropsychiatric systemic lupus erythematosus at conception, but only one remained with neurological activity during gestation, characteristically related to the inadvertent suspension of medications...
April 2017: Lupus
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