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https://www.readbyqxmd.com/read/28091442/fluoride-release-recharging-ability-and-bond-strength-of-glass-ionomer-cements-to-sound-and-caries-affected-dentin
#1
E Kucukyilmaz, S Savas, F Kavrik, B Yasa, M S Botsali
OBJECTIVES: The aim of this in vitro study was to evaluate the microtensile bond strength (μTBS) of different glass ionomer cements (GICs) on sound/caries-affected dentin and to assess the fluoride release/recharging ability. METHODS: After creating artificial caries lesions, teeth with sound and caries-affected dentin were assigned to be restored with one of the GICs: Ketac N100; GC Equia; GCP Glass Fill, and tested using a microtensile test. Ten of each material were prepared, and fluoride ion-release was measured at 10 different intervals...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28025611/evidence-and-evidence-gaps-an-introduction
#2
REVIEW
Gabriele Dreier, Jan Löhler
Background: Medical treatment requires the implementation of existing evidence in the decision making process in order to be able to find the best possible diagnostic, therapeutic or prognostic measure for the individual patient based on the physician's own expertise. Clinical trials form the evidence base and ideally, their results are assembled, analyzed, summarized, and made available in systematic review articles. Beside planning, conducting, and evaluating clinical trials in conformity with GCP (good clinical practice), it is essential that all results of conducted studies are publicly available in order to avoid publication bias...
2016: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/28012628/syneresis-and-rheological-behaviors-of-set-yogurt-containing-green-tea-and-green-coffee-powders
#3
Özge Dönmez, Burçe Ataç Mogol, Vural Gökmen
This study aimed to investigate the effect of added green coffee powder (GCP) and green tea powder (GTP) on syneresis behavior and consistency of set yogurts. Adding GCP (1 or 2%) decreased syneresis rate. It was confirmed that the effect of GTP on the syneresis rate was concentration dependent. In comparison to the control, GTP decreased syneresis rate when it was added at 0.02%, but it caused an increase when added at 2%. No significant difference was observed in the syneresis rates when GTP was added at amounts of 1 and 0...
December 21, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/28010731/a-survey-of-facilitators-and-barriers-to-recruitment-to-the-magnetic-trial
#4
Geetinder Kaur, Rosalind L Smyth, Colin V E Powell, Paula Williamson
BACKGROUND: Recruitment to randomised controlled trials with children is challenging. It is imperative to understand the factors that boost or hinder recruitment of children to clinical trials. We conducted a survey of facilitators and barriers to recruitment to the MAGNETIC trial, using a previously developed web-based tool. METHODS: MAGNETIC is a multicentre randomised trial of nebulised magnesium in acute severe asthma, recruiting 508 children from 30 UK sites...
December 23, 2016: Trials
https://www.readbyqxmd.com/read/27936371/testing-cross-sectional-and-prospective-mediators-of-internalized-heterosexism-on-heavy-drinking-alcohol-problems-and-psychological-distress-among-heavy-drinking-men-who-have-sex-with-men
#5
Alexis Kuerbis, Ethan H Mereish, Marie Hayes, Christine M Davis, Sijing Shao, Jon Morgenstern
OBJECTIVE: Minority stress theory is one of the primary theories used to understand substance use among lesbian, gay, and bisexual populations. This study tested whether drinking to cope with stress (DTC), loneliness, and gay community participation (GCP) mediated the relationship between one type of minority stress (i.e., internalized heterosexism) and behavioral health outcomes. METHOD: Using secondary data analysis and the PROCESS procedure, relationships between internalized heterosexism, the mediators (DTC, loneliness, and GCP), and outcomes (heavy drinking, alcohol problems, and psychological distress) were explored, both cross-sectionally and in a lagged manner, among both treatment-seeking and non-treatment-seeking problem drinking men who have sex with men...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27914669/effect-of-different-thermo-light-polymerization-on-flexural-strength-of-two-glass-ionomer-cements-and-a-glass-carbomer%C3%A2-cement
#6
Kristina Gorseta, Ali Borzabadi-Farahani, Alireza Moshaverinia, Domagoj Glavina, Edward Lynch
STATEMENT OF PROBLEM: Whether polymerization lights can be used for heating glass ionomer cements (GICs) or glass carbomer (GCP) to improve their mechanical properties is not well established. PURPOSE: The purpose of this in vitro study was to assess the effect of thermo-light polymerization on the flexural strength (FS) of 2 GICs (Fuji IX GP Fast, Ketac Molar) and a GCP. MATERIAL AND METHODS: Specimens (n=10) were prepared in stainless steel molds (2×2×25 mm), compressed, exposed to 3 polymerization lights (500, 1000, 1200 mW/cm(2)) for 2 cycles of 40 seconds on each side, and stored in petroleum jelly (37°C, 24 hours)...
November 30, 2016: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/27882064/the-evaluation-and-comparison-of-transcriptionally-targeted-noxa-and-puma-killer-genes-to-initiate-apoptosis-under-cancer-specific-promoter-cxcr1-in-hepatocarcinoma-gene-therapy
#7
Shahryar Khoshtinat Nikkhoi, Hedieh Heydarzadeh, Saeed Ranjbar, Fatemeh Salimi, Masoud Aghaeifard, Seyed Moayed Alavian, Azadeh Reshadmanesh
BACKGROUND: Cancerous cells proliferate as fast as possible without a proper surveillance system. This rapid cell division leads to enormous mutation rates, which help a tumor establish. OBJECTIVES: This study evaluated the potential of inducing apoptosis using Noxa and Puma in a hepatocarcinoma cell line. METHODS: The current study generated two recombinant lentiviruses, pLEX-GCN and pLEX-GCP, bearing Noxa and Puma, respectively. Transduction of both genes to hepatocarcinoma (HepG2) was verified using fluorescent microscopic analysis, western blotting, and quantitative real-time polymerase chain reaction (PCR)...
October 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27863592/nursing-interventions-in-stroke-care-delivery-an-evidence-based-clinical-review
#8
Dimitrios Theofanidis, Bernard Gibbon
INTRODUCTION: Generally, nursing interventions during the acute stages following a stroke aim at preventing secondary brain injury (intracranial hypertension), maintaining the airways (due to paralysis of the pharynx muscles), providing general body support (vital signs, fluid and electrolyte balance), and anticipating the occurrence of complications (atelectasis and pneumonia). AIM: This literature review is to prioritize nursing interventions for acute stroke and to update nursing roles and input considering recommended levels of evidence of care to date...
December 2016: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/27809395/ph-controlled-formation-of-a-stable-%C3%AE-sheet-and-amyloid-like-fibers-from-an-amphiphilic-peptide-the-importance-of-a-tailor-made-binding-motif-for-secondary-structure-formation
#9
Poulami Jana, Martin Ehlers, Elio Zellermann, Krishnananda Samanta, Carsten Schmuck
The new amphiphilic peptide 1 is composed of alternating cyclohexyl side chains and guanidiniocarbonyl pyrrole (GCP) groups. In contrast to analogue 2, which contains lysine instead of the GCP groups and only exists as a random coil owing to charge repulsion, peptide 1 forms a stable β-sheet at neutral pH in aqueous medium. The weakly basic GCP groups (pKa ≈7) are key for secondary structure formation as they stabilize the β-sheet through mutual interactions (formation of a "GCP zipper"). The β-sheets further aggregate into left-handed helically twisted fibers...
November 3, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27802424/dual-role-of-the-integrated-stress-response-in-medulloblastoma-tumorigenesis
#10
Sarrabeth Stone, Yeung Ho, Xiting Li, Stephanie Jamison, Heather P Harding, David Ron, Wensheng Lin
In response to endoplasmic reticulum (ER) stress, activation of pancreatic ER kinase (PERK) coordinates an adaptive program known as the integrated stress response (ISR) by phosphorylating translation initiation factor 2α (eIF2α). Phosphorylated eIF2α is quickly dephosphorylated by the protein phosphatase 1 and growth arrest and DNA damage 34 (GADD34) complex. Data indicate that the ISR can either promote or suppress tumor development. Our previous studies showed that the ISR is activated in medulloblastoma in both human patients and animal models, and that the decreased ISR via PERK heterozygous deficiency attenuates medulloblastoma formation in Patched1 heterozygous deficient (Ptch1+/-) mice by enhancing apoptosis of pre-malignant granule cell precursors (GCPs) during cell transformation...
September 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27762509/analytical-and-clinical-evaluation-of-an-immunoassay-for-estimating-immunogenicity-of-infliximab-and-etanercept-in-indian-population
#11
Canna Ghia, Shashank Akerkar, Shailaja Sabnis, Urk Rao, Gautam Rambhad
BACKGROUND / OBJECTIVES: Biologic anti-TNFs in India have improved the patient management. Significant proportions of patients lose response over time or do not respond. Possible explanations are suboptimal trough anti-TNFa concentrations or antibodies to anti-TNFs. The aim of this project was to set up and standardize an independent laboratory to test immunogenicity of anti-TNF biologics (infliximab and etanercept). METHODS: Three rheumatologists piloted this project approved by independent ethics committee and carried out in compliance with ICH/GCP guidelines...
September 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27711304/guanidiniocarbonyl-pyrrole-gcp-conjugated-pamam-g2-a-highly-efficient-vector-for-gene-delivery-the-importance-of-dna-condensation
#12
Krishnananda Samanta, Poulami Jana, Sandra Bäcker, Shirley Knauer, Carsten Schmuck
A novel hybrid compound 1 efficiently shuttles genetic material into HeLa cells at concentrations as low as 0.6 μM, whereas the parent compound PAMAM-G2 is ineffective even at 200 μM. The high efficiency of 1 stems from its capabiliy to form highly condensed ligand-DNA polyplexes. Its binding affinity is actually lower than for the parent dendrimer. Compound 1 is even 200 times more effective and less cytotoxic than PEI, the current gold standard in gene transfection with cationic polymers.
October 13, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27683777/masticatory-function-of-obese-candidates-to-bariatric-surgery-from-distinct-socioeconomic-classes
#13
Celso Roberto Passeri, Jacira Alves Caracik de Camargo Andrade, Karla Thaíza Tomal, Eduardo Marcucci Pracucho, Livia Paschoalino de Campos, Silvia Helena de Carvalho Sales-Peres
Background: Obesity and metabolic syndrome can be labeled as worldwide outbreak; thus, both have led to serious public health problem. Oral health can be worsened by both, obesity and metabolic syndrome. Tooth loss harms masticatory function, essential status to whom will be submitted to bariatric surgery. Aim: Assess masticatory function of obese candidates to bariatric surgery, who belong to distinct socioeconomic class range, in order to recognize hazard factors and the bias of socioeconomic factor in this context...
2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27671301/polo-like-kinase-1-targeting-chitosan-nanoparticles-suppress-the-progression-of-hepatocellular-carcinoma
#14
Dongzhi Wang, Renan Chang, Gang Wang, Baoying Hu, Yong Qiang, Zhong Chen
BACKGROUND: Recent investigations have implicated that Chitosan-nucleotide nanoparticles might be useful non-viral carriers in gene therapy. Polo-like kinase 1 (PLK1) has been reported to be an important oncogene that exerted considerable therapeutic value in hepatocellular carcinoma (HCC). OBJECTIVE: We explored whether Galactosylated chitosan-graft-poly(ethylene glycol) (GCP) nanoparticle-mediated delivery of PLK1 siRNA nucleotides could serve as an effective anti-cancer agent for HCC therapy...
September 26, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27647793/preoperative-cognitive-performance-dominates-risk-for-delirium-among-older-adults
#15
Richard N Jones, Edward R Marcantonio, Jane S Saczynski, Douglas Tommet, Alden L Gross, Thomas G Travison, David C Alsop, Eva M Schmitt, Tamara G Fong, Sevdenur Cizginer, Mouhsin M Shafi, Alvaro Pascual-Leone, Sharon K Inouye
BACKGROUND: Cognitive impairment is a well-recognized risk factor for delirium. Our goal was to determine whether the level of cognitive performance across the nondemented cognitive ability spectrum is correlated with delirium risk and to gauge the importance of cognition relative to other known risk factors for delirium. METHODS: The Successful Aging after Elective Surgery study enrolled 566 adults aged ≥70 years scheduled for major surgery. Patients were assessed preoperatively and daily during hospitalization for the occurrence of delirium using the Confusion Assessment Method...
September 19, 2016: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/27641969/risk-based-monitoring-rbm-tools-for-clinical-trials-a-systematic-review
#16
Caroline Hurley, Frances Shiely, Jessica Power, Mike Clarke, Joseph A Eustace, Evelyn Flanagan, Patricia M Kearney
INTRODUCTION: In November 2016, the Integrated Addendum to ICH-GCP E6 (R2) will advise trial sponsors to develop a risk-based approach to clinical trial monitoring. This new process is commonly known as risk based monitoring (RBM). To date, a variety of tools have been developed to guide RBM. However, a gold standard approach does not exist. This review aims to identify and examine RBM tools. METHODS: Review of published and grey literature using a detailed search-strategy and cross-checking of reference lists...
September 15, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27631773/a-proposed-road-map-for-the-ethical-evaluation-of-sham-placebo-surgery
#17
Vittoradolfo Tambone, Dario Sacchini, Antonio G Spagnolo, Rosa Menga, Giovanna Ricci, Roberto Valenti, Massimiliano Andrea Vitali, Massimo Ciccozzi
OBJECTIVE: The study proposes a possible roadmap for the ethical assessment of sham surgery clinical trials (CTs), focusing on methodological aspects, as a result of the lack of this type of practical tool in the literature/practice. BACKGROUND: Surgical procedures are frequently conducted without closely controlled studies. For this reason, these procedures are less rigorous than those for drug/device clinical trials. The aim of a sham (placebo) surgery CT is to carry out a surgical CT with a legitimate control group...
September 14, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27513682/gingival-crevicular-fluid-and-saliva-stress-hormone-levels-in-patients-with-chronic-and-aggressive-periodontitis
#18
Omer Cakmak, Zekeriya Tasdemir, Cuneyt Asim Aral, Serkan Dundar, Halit Bugra Koca
AIM: This cross-sectional study aims to analyse cortisol and dehydroepiandrosterone (DHEA) levels in gingival crevicular fluid (GCF) and saliva in generalized aggressive periodontitis (GAP) and generalized chronic periodontitis (GCP) patients, as well as in periodontally healthy individuals (C). MATERIAL AND METHODS: A total of 92 patients (31 C, 34 GCP and 27 GAP) were included in the study. Clinical parameters including plaque index, gingival index, bleeding on probing, probing depth and clinical attachment level; psychosocial measurements including Beck depression inventory and state-trait anxiety inventory; and hormone levels in GCF and saliva including cortisol and DHEA were evaluated...
August 11, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27498965/promoting-good-health-research-practice-in-low-and-middle-income-countries
#19
Yodi Mahendradhata, Jamila Nabieva, Riris Andono Ahmad, Patricia Henley, Pascal Launois, Corinne Merle, Christine Maure, Olaf Horstick, Varalakshmi Elango
BACKGROUND: Good clinical practice (GCP) guidelines have been the source of improvement in the quality of clinical trials; however, there are limitations to the application of GCP in the conduct of health research beyond industry-sponsored clinical trials. The UNICEF/UNDP/World Bank/WHO Special Program for Research and Training in Tropical Disease is promoting good practice in all health research involving human through the Good Health Research Practice (GHRP) training program initiative...
2016: Global Health Action
https://www.readbyqxmd.com/read/27453828/comparison-of-good-clinical-practice-compliance-and-readability-ease-of-the-informed-consents-between-observational-and-interventional-clinical-studies-in-the-emirates
#20
Satish Chandrasekhar Nair, Halah Ibrahim, Omar Sherif Askar
BACKGROUND: Expansion of clinical trials activity into emerging regions has raised concerns regarding participant rights and research ethics. Increasing numbers of observational studies are now conducted in developing economies, including the United Arab Emirates. MATERIALS AND METHODS: This study compares the content of information provided, Good Clinical Practice (GCP) guideline compliance, and readability of informed consent forms (ICFs) for observational compared to interventional studies...
July 2016: Perspectives in Clinical Research
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