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https://www.readbyqxmd.com/read/28329149/prediction-of-long-term-cognitive-decline-following-postoperative-delirium-in-older-adults
#1
Elizabeth E Devore, Tamara G Fong, Edward R Marcantonio, Eva M Schmitt, Thomas G Travison, Richard N Jones, Sharon K Inouye
Background: Increasing evidence suggests that postoperative delirium may result in long-term cognitive decline among older adults. Risk factors for such cognitive decline are unknown. Methods: We studied 126 older participants without delirium or dementia upon entering the Successful AGing After Elective Surgery (SAGES) study, who developed postoperative delirium and completed repeated cognitive assessments (up to 36 months of follow-up). Pre-surgical factors were assessed preoperatively and divided into nine groupings of related factors ("domains")...
March 15, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28301035/comparison-among-the-efficacy-of-interventions-for-the-return-rate-to-receive-the-pap-test-report-randomized-controlled-clinical-trial
#2
Camila Teixeira Moreira Vasconcelos, Ana Karina Bezerra Pinheiro, Ana Izabel Oliveira Nicolau, Thaís Marques Lima, Denise de Fátima Fernandes Barbosa
Objective: to test the effects of a behavioral, an educative and a comparative intervention on women's adherence to the return appointment to receive the pap test report. Methods: randomized controlled clinical trial at a Primary Health Care Service, involving three groups: EG (educative session and test demonstration), BG (recall ribbon) and standard intervention (card containing the return appointment - graphical reminder), called comparative group here (CG). To select the sample, the following was established: having started sexual activity and undergoing the pap smear during the study, resulting in 775 women...
March 2, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28279629/searching-for-global-consciousness-a-17-year-exploration
#3
Peter A Bancel
The Global Consciousness Project (GCP) maintains a long-term experiment that investigates the possibility of a subtle connection between the collective mental activity of humans and the physical behavior of systems in the surrounding environment. The Project formulates this proposition as a broad hypothesis that relates the output of true random number generators (RNGs) to times of intense, collective mental attention during major world events. Over 17 years, the hypothesis has been tested on nearly 500 events, yielding a cumulative result that rejects the null hypothesis by seven standard deviations, apparently lending strong support to the proposal of global consciousness...
December 18, 2016: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28246537/effectiveness-and-safety-of-acupuncture-for-poststroke-dysphagia-study-protocol-for-a-pragmatic-multicenter-nonrandomized-controlled-trial
#4
Yu Tat Chan, Hong Wei Zhang, Yuan Qi Guo, Zhi-Xiu Lin
Background. Dysphagia is one of the most common complications of stroke. Acupuncture is widely employed to treat poststroke dysphagia in East Asia. No evidence is established to support such treatment approach. This proposed study aims to evaluate the effectiveness and safety of acupuncture for the treatment of poststroke dysphagia. Methods and Design. This is a multicenter, pragmatic, single-blinded, nonrandomized controlled clinical trial. A total of 140 eligible patients will be enrolled in the study. Subjects who are eligible in study but refuse to have acupuncture treatment will be put on the no-acupuncture control arm...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28214233/incorporation-of-arginine-mimetic-residue-into-peptides-for-recognition-of-double-stranded-nucleic-acid-structure-binding-and-aggregation-studies
#5
Mao Li, Marija Matković, Ivo Piantanida, Carsten Schmuck
An arginine mimetic, featuring a guanidiniocarbonypyrrol as artificial anion binding site (GCP), was introduced into short peptides to study their binding and aggregation with double stranded DNA and RNA. While the incorporation of this GCP modification did not significantly change the overall binding affinity for DNA/RNA, their interactions were more sensitive with respect to the type of polynucleotides. Peptide 4, with four GCP modifications, exhibited amazing fluorescent selectivity for AU- and (to a lesser extent) AT- sequences...
February 6, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28184381/a-multicenter-longitudinal-interventional-double-blind-randomized-clinical-trial-in-hematopoietic-cell-transplant-recipients-residing-in-remote-areas-lessons-learned-from-the-late-cytomegalovirus-prevention-trial
#6
Louise E Kimball, Terry Stevens-Ayers, Margaret L Green, Hu Xie, Mary E D Flowers, Keith R Jerome, Renee LeBlanc, Christi Dahlgren, W Garrett Nichols, Roy F Chemaly, G Papanicolaou, Michael Boeckh
PURPOSE: The logistics of conducting double-blinded phase III clinical trials with participants residing in remote locations are complex. Here we describe the implementation of an interventional trial for the prevention of late cytomegalovirus (CMV) disease in hematopoietic cell transplantation (HCT) subjects in a long-term follow-up environment. METHODS: A total of 184 subjects at risk for late CMV disease surviving 80 days following allogeneic HCT were randomized to receive six months of valganciclovir or placebo...
December 15, 2016: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/28167745/standardisation-of-delivery-and-assessment-of-research-training-for-specialty-trainees-based-on-curriculum-requirements-recommendations-based-on-a-scoping-review
#7
Amar Rangan, James Pitchford, Penny Williams, Brian Wood, Stephen Robson
OBJECTIVES: (1) To conduct a scoping review of postgraduate specialty training (ST) curricula for doctors within Health Education England in order to identify common themes and variations in requirements for training and assessment of research competencies. (2) To make recommendations on standardisation of training for clinical research across ST programmes. SETTING: Health Education England North East and National Institute for Health Research Clinical Research Network (CRN)-North East and North Cumbria...
February 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28165338/the-chromatin-remodeling-factor-chd7-controls-cerebellar-development-by-regulating-reelin-expression
#8
Danielle E Whittaker, Kimberley L H Riegman, Sahrunizam Kasah, Conor Mohan, Tian Yu, Blanca Pijuan Sala, Husam Hebaishi, Angela Caruso, Ana Claudia Marques, Caterina Michetti, María Eugenia Sanz Smachetti, Apar Shah, Mara Sabbioni, Omer Kulhanci, Wee-Wei Tee, Danny Reinberg, Maria Luisa Scattoni, Holger Volk, Imelda McGonnell, Fiona C Wardle, Cathy Fernandes, M Albert Basson
The mechanisms underlying the neurodevelopmental deficits associated with CHARGE syndrome, which include cerebellar hypoplasia, developmental delay, coordination problems, and autistic features, have not been identified. CHARGE syndrome has been associated with mutations in the gene encoding the ATP-dependent chromatin remodeler CHD7. CHD7 is expressed in neural stem and progenitor cells, but its role in neurogenesis during brain development remains unknown. Here we have shown that deletion of Chd7 from cerebellar granule cell progenitors (GCps) results in reduced GCp proliferation, cerebellar hypoplasia, developmental delay, and motor deficits in mice...
March 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28152909/quality-assurance-metrics-in-clinical-trial-conduct
#9
Susanna Sellmann, Lindsay Philip, Cristina Guglielmi, Pamela Degendorfer, Amit M Oza
274 Background: Quality assurance (QA) in clinical trials is a safeguard against non-compliance, which impacts patient safety and data integrity. On an institutional level, compiling quality findings provides insight to gaps within existing processes, protocol compliance, and educational content. A QA metrics methodology has been implemented, which is streamlined with the ICH-GCP, and institutional Standard Operating Procedures (SOPs) and policies. METHODS: Individual findings are assigned an alphanumerical code, based on severity and category, and a reference for each Quality Assurance Review (QAR)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152764/initiative-to-streamline-clinical-trials-isct-guidance-for-academic-investigators-sponsors
#10
Katherine Brodeur-Robb, Alison May Urton, Jacqueline Bosch, Lesley Seymour, Karen E Arts
219 Background: The 2011 Canadian Cancer Research Alliance (CCRA) report on the State of Cancer Clinical Trials in Canada outlined in detail the threats to the conduct of academic oncology clinical trials caused by increasing complexity and workload resulting from a perceived onerous regulatory environment. The report recommended engaging Health Canada and key stakeholders to foster agreement in appropriate interpretations of the Canadian Food and Drug Regulations Part C Division 5 and ICH Good Clinical Practice (GCP) guidelines...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28147379/decidualization-mediated-by-steroid-hormones-modulates-the-innate-immunity-in-response-to-group-b-streptococcal-infection-in-vitro
#11
Violeta Castro-Leyva, Veronica Zaga-Clavellina, Aurora Espejel-Nuñez, Rodrigo Vega-Sanchez, Arturo Flores-Pliego, Enrique Reyes-Muñoz, Silvia Giono-Cerezo, Sonia Nava-Salazar, Salvador Espino Y Sosa, Guadalupe Estrada-Gutierrez
BACKGROUND: Decidual cells play a role in the modulation of the innate immune response to protect pregnancy against infection. Steroid hormones regulate the innate immune response in different tissues, and they are involved in several biological processes like decidualization. The aim of this study was to assess if steroid hormones modulate the innate immunity in endometrial stromal cells (ESCs) and decidual stromal cells (DSCs) in response to group B streptococcus (GBS) infection in vitro...
February 2, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28142317/inventing-atomic-resolution-scanning-dielectric-microscopy-to-see-a-single-protein-complex-operation-live-at-resonance-in-a-neuron-without-touching-or-adulterating-the-cell
#12
Lokesh Agrawal, Satyajit Sahu, Subrata Ghosh, Takashi Shiga, Daisuke Fujita, Anirban Bandyopadhyay
A substantial ion flow in a normally wet protein masks any other forms of signal transmission. We use hysteresis and linear conduction (both are artifacts) as a marker to precisely wet a protein, which restricts the ionic conduction (hysteresis disappears), and at the same time, it is not denatured (quantized conductance and Raman spectra are intact). Pure electric visualization of proteins at work by eliminating the screening of ions, electrons, would change the way we study biology. Here we discuss the technical challenges resolved for imaging a protein or live cell using nonlinear dielectric response (spatial distribution of conductance, capacitance and phase, GCP trio)...
December 2016: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/28132008/compensatory-changes-in-energy-balance-during-dapagliflozin-treatment-in-type-2-diabetes-mellitus-a-randomised-double-blind-placebo-controlled-cross-over-trial-energize-study-protocol
#13
Surya Panicker Rajeev, Victoria S Sprung, Carl Roberts, Jo A Harrold, Jason C G Halford, Andrej Stancak, Emma J Boyland, Graham J Kemp, Daniel J Cuthbertson, John P H Wilding
INTRODUCTION: Sodium glucose cotransporter 2 (SGLT2) inhibitors are effective blood-glucose-lowering medications with beneficial effects on body weight in patients with type 2 diabetes mellitus (T2DM). However, observed weight loss is less than that predicted from quantified glycosuria, suggesting a compensatory increase in energy intake or a decrease in energy expenditure. Studies using dual-energy X-ray absorptiometry (DEXA) have suggested most body weight change is due to loss of adipose tissue, but organ-specific changes in fat content (eg, liver, skeletal muscle) have not been determined...
January 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28107010/phase-equilibria-of-water-co2-and-water-n-alkane-mixtures-from-polarizable-models
#14
Hao Jiang, Ioannis G Economou, Athanassios Z Panagiotopoulos
Phase equilibria of water/CO2 and water/n-alkane mixtures over a range of temperatures and pressures were obtained from Monte Carlo simulations in the Gibbs ensemble. Three sets of Drude-type polarizable models for water, namely the BK3, GCP, and HBP models, were combined with a polarizable Gaussian charge CO2 (PGC) model to represent the water/CO2 mixture. The HBP water model describes hydrogen bonds between water and CO2 explicitly. All models underestimate CO2 solubility in water if standard combining rules are used for the dispersion interactions between water and CO2...
February 2, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28091442/fluoride-release-recharging-ability-and-bond-strength-of-glass-ionomer-cements-to-sound-and-caries-affected-dentin
#15
E Kucukyilmaz, S Savas, F Kavrik, B Yasa, M S Botsali
OBJECTIVES: The aim of this in vitro study was to evaluate the microtensile bond strength (μTBS) of different glass ionomer cements (GICs) on sound/caries-affected dentin and to assess the fluoride release/recharging ability. METHODS: After creating artificial caries lesions, teeth with sound and caries-affected dentin were assigned to be restored with one of the GICs: Ketac N100; GC Equia; GCP Glass Fill, and tested using a microtensile test. Ten of each material were prepared, and fluoride ion-release was measured at 10 different intervals...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28025611/evidence-and-evidence-gaps-an-introduction
#16
REVIEW
Gabriele Dreier, Jan Löhler
Background: Medical treatment requires the implementation of existing evidence in the decision making process in order to be able to find the best possible diagnostic, therapeutic or prognostic measure for the individual patient based on the physician's own expertise. Clinical trials form the evidence base and ideally, their results are assembled, analyzed, summarized, and made available in systematic review articles. Beside planning, conducting, and evaluating clinical trials in conformity with GCP (good clinical practice), it is essential that all results of conducted studies are publicly available in order to avoid publication bias...
2016: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/28012628/syneresis-and-rheological-behaviors-of-set-yogurt-containing-green-tea-and-green-coffee-powders
#17
Özge Dönmez, Burçe Ataç Mogol, Vural Gökmen
This study aimed to investigate the effect of added green coffee powder (GCP) and green tea powder (GTP) on syneresis behavior and consistency of set yogurts. Adding GCP (1 or 2%) decreased syneresis rate. The effect of GTP on the syneresis rate was concentration dependent. In comparison to the control, GTP decreased syneresis rate when it was added at 0.02%, but it caused an increase when added at 2%. No significant difference was observed in the syneresis rates when GTP was added at 1 and 0.01%, until 14 and 7 d of storage, respectively...
February 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28010731/a-survey-of-facilitators-and-barriers-to-recruitment-to-the-magnetic-trial
#18
Geetinder Kaur, Rosalind L Smyth, Colin V E Powell, Paula Williamson
BACKGROUND: Recruitment to randomised controlled trials with children is challenging. It is imperative to understand the factors that boost or hinder recruitment of children to clinical trials. We conducted a survey of facilitators and barriers to recruitment to the MAGNETIC trial, using a previously developed web-based tool. METHODS: MAGNETIC is a multicentre randomised trial of nebulised magnesium in acute severe asthma, recruiting 508 children from 30 UK sites...
December 23, 2016: Trials
https://www.readbyqxmd.com/read/27936371/testing-cross-sectional-and-prospective-mediators-of-internalized-heterosexism-on-heavy-drinking-alcohol-problems-and-psychological-distress-among-heavy-drinking-men-who-have-sex-with-men
#19
Alexis Kuerbis, Ethan H Mereish, Marie Hayes, Christine M Davis, Sijing Shao, Jon Morgenstern
OBJECTIVE: Minority stress theory is one of the primary theories used to understand substance use among lesbian, gay, and bisexual populations. This study tested whether drinking to cope with stress (DTC), loneliness, and gay community participation (GCP) mediated the relationship between one type of minority stress (i.e., internalized heterosexism) and behavioral health outcomes. METHOD: Using secondary data analysis and the PROCESS procedure, relationships between internalized heterosexism, the mediators (DTC, loneliness, and GCP), and outcomes (heavy drinking, alcohol problems, and psychological distress) were explored, both cross-sectionally and in a lagged manner, among both treatment-seeking and non-treatment-seeking problem drinking men who have sex with men...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27914669/effect-of-different-thermo-light-polymerization-on-flexural-strength-of-two-glass-ionomer-cements-and-a-glass-carbomer%C3%A2-cement
#20
Kristina Gorseta, Ali Borzabadi-Farahani, Alireza Moshaverinia, Domagoj Glavina, Edward Lynch
STATEMENT OF PROBLEM: Whether polymerization lights can be used for heating glass ionomer cements (GICs) or glass carbomer (GCP) to improve their mechanical properties is not well established. PURPOSE: The purpose of this in vitro study was to assess the effect of thermo-light polymerization on the flexural strength (FS) of 2 GICs (Fuji IX GP Fast, Ketac Molar) and a GCP. MATERIAL AND METHODS: Specimens (n=10) were prepared in stainless steel molds (2×2×25 mm), compressed, exposed to 3 polymerization lights (500, 1000, 1200 mW/cm(2)) for 2 cycles of 40 seconds on each side, and stored in petroleum jelly (37°C, 24 hours)...
November 30, 2016: Journal of Prosthetic Dentistry
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