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https://www.readbyqxmd.com/read/29786662/study-on-the-discrimination-between-citri-reticulatae-pericarpium-varieties-based-on-hs-spme-gc-ms-combined-with-multivariate-statistical-analyses
#1
Yuying Zheng, Xuan Zeng, Wei Peng, Zhong Wu, Weiwei Su
Citri reticulatae pericarpium (CRP), the dried pericarps of Citrus reticulata Blanco and its cultivars, has been widely used in drugs and foods in China for centuries. In this study, an accurate and feasible analytical method based on HS-SPME-GC-MS coupled with multivariate statistical analyses was developed to comprehensively compare volatile compounds of pericarps derived from Citrus reticulata "Chachi" ("Guangchenpi" in Chinese, GCP) and other cultivars of Citrus reticulata Blanco ("Chenpi" in Chinese, CP)...
May 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29770977/formation-of-twisted-%C3%AE-sheet-tapes-from-a-self-complementary-peptide-based-on-novel-pillararene-gcp-host-guest-interaction-with-gene-transfection-properties
#2
Carsten Schmuck, Xiao-Yu Hu, Martin Ehlers, Elio Zellermann, Stefanie Mosel, Hao Jiang, Jan-Erik Ostwaldt, Shirley Knauer, Leyong Wang, Tingting Wang
Small peptides capable of assembling into well-defined nanostructures have attracted extensive attention due to their interesting applications as biomaterials. Herein, we report the first example of a pillararene functionalized with a guanidiniocarbonyl pyrrole (GCP)-conjugated short peptide segment. The obtained amphiphilic peptide 1 spontaneously self-assembles into a supramolecular β-sheet in aqueous solution based on host-guest interaction between pillararene and GCP unit as well as hydrogen-bonding between the peptide strands...
May 17, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29742190/a-natural-cream-to-powder-formulation-developed-for-the-prevention-of-diaper-dermatitis-in-diaper-wearing-infants-and-children-barrier-property-and-in-use-tolerance-studies
#3
Hemali B Gunt, Stanley B Levy, Celeste A Lutrario
INTRODUCTION: Diaper dermatitis is a common condition that develops in the diaper area due to factors such as elevated moisture, increased skin surface pH, and exposure to irritants from urine and feces. These factors suggest interventions to prevent or treat diaper dermatitis such as exposing the skin to air, frequent diaper changes, and thorough cleansing of the diaper area. Barrier creams and powders also have a role in preventing and treating diaper dermatitis. We developed a cream-to-powder product with a formula based on corn starch and other natural ingredients for use in the diaper area...
May 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29723852/flexural-strength-of-glass-carbomer-cement-and-conventional-glass-ionomer-cement-stored-in-different-storage-media-over-time
#4
Muhammad Ali Faridi, Abdul Khabeer, Saad Haroon
OBJECTIVES: Glass Ionomer Cement (GIC) is routinely placed as a restorative material in dentistry. However, due to its poor physical properties, its use is limited to cases where the level of stress on the restoration is minimal. Improved formulations of GIC have been developed to overcome these drawbacks. The purpose of the study was to evaluate the flexural strength of a conventional GIC (Fuji IX) against the newly developed Glass Carbomer Cement (GCP). MATERIALS AND METHODS: A total of 80 blocks for Fuji IX and GCP were prepared and divided into 16 groups (n = 5)...
May 3, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29719318/contemporary-aspects-of-marketing-in-clinical-trials-including-segments-of-it-and-technology-transfer
#5
Milorad Stamenovic, Amra Dobraca, Mersiha Smajlovic
Introduction: The aim of this paper is to present the marketing strategy and the application of management (marketing management) and advertising in order to increase the efficiency of innovative approach in clinical trials that include and involve the use of new technologies and transfer of technologies. Material and Methods: This paper has a descriptive character and represents a narrative review of the literature and new model implementation. Results: Marketing models are primarily used to improve the inclusion of a larger (and appropriate) number of patients, but they can be credited for the stay and monitoring of patients in the trial...
2018: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/29699559/-screening-audit-as-a-quality-assurance-tool-in-good-clinical-practice-compliant-research-environments
#6
Sinyoung Park, Chung Mo Nam, Sejung Park, Yang Hee Noh, Cho Rong Ahn, Wan Sun Yu, Bo Kyung Kim, Seung Min Kim, Jin Seok Kim, Sun Young Rha
BACKGROUND: With the growing amount of clinical research, regulations and research ethics are becoming more stringent. This trend introduces a need for quality assurance measures for ensuring adherence to research ethics and human research protection beyond Institutional Review Board approval. Audits, one of the most effective tools for assessing quality assurance, are measures used to evaluate Good Clinical Practice (GCP) and protocol compliance in clinical research. However, they are laborious, time consuming, and require expertise...
April 25, 2018: BMC Medical Ethics
https://www.readbyqxmd.com/read/29674766/the-combination-of-gemcitabine-cisplatin-and-paclitaxel-as-salvage-chemotherapy-for-advanced-urothelial-carcinoma
#7
Takeshi Hirata, Masanori Hanamoto, Kazuma Ogura, Nobuki Hayashi, Kosuke Takamura, Kohei Edamura, Shin Ebara, Takashi Saika
There is no standard second-line or salvage treatment for advanced urothelial carcinoma (UC). Here we investigated the efficacy and safety of gemcitabine, cisplatin, and paclitaxel (GCP) combination chemotherapy as salvage chemotherapy for advanced UC. We retrospectively analyzed the cases of 23 patients with advanced UC who showed progression or recurrence after cisplatin-based chemotherapy. Gemcitabine (1000 mg/m2), and paclitaxel (80 mg/m2) were administered on days 1 and 8. Cisplatin (70 mg/m2) was administered on day 1...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29659744/human-adipose-mesenchymal-stem-cells-overexpressing-dual-chemotactic-gene-showed-enhanced-angiogenic-capacity-in-ischemic-hindlimb-model
#8
Younggeul Min, Seongho Han, Hyun Aae Ryu, Sung-Whan Kim
Aims: In present study, we sought to characterize the angio-vasculogenic property of human adipose mesenchymal stem cells (ASCs) overexpressing dual chemokine GCP-2 and SDF-1α (ASC-G/S) and to determine the therapeutic potential of ASC-G/S in the context of experimental ischemia. Methods and results: We generated ASC-G/S line and performed flow cytometry, quantitative (q)-PCR, Matrigel tube formation, Matrigel plug assays and in vivo therapeutic assays using hind limb ischemia mouse model...
April 5, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29655704/a-library-of-phosphoproteomic-and-chromatin-signatures-for-characterizing-cellular-responses-to-drug-perturbations
#9
Lev Litichevskiy, Ryan Peckner, Jennifer G Abelin, Jacob K Asiedu, Amanda L Creech, John F Davis, Desiree Davison, Caitlin M Dunning, Jarrett D Egertson, Shawn Egri, Joshua Gould, Tak Ko, Sarah A Johnson, David L Lahr, Daniel Lam, Zihan Liu, Nicholas J Lyons, Xiaodong Lu, Brendan X MacLean, Alison E Mungenast, Adam Officer, Ted E Natoli, Malvina Papanastasiou, Jinal Patel, Vagisha Sharma, Courtney Toder, Andrew A Tubelli, Jennie Z Young, Steven A Carr, Todd R Golub, Aravind Subramanian, Michael J MacCoss, Li-Huei Tsai, Jacob D Jaffe
Although the value of proteomics has been demonstrated, cost and scale are typically prohibitive, and gene expression profiling remains dominant for characterizing cellular responses to perturbations. However, high-throughput sentinel assays provide an opportunity for proteomics to contribute at a meaningful scale. We present a systematic library resource (90 drugs × 6 cell lines) of proteomic signatures that measure changes in the reduced-representation phosphoproteome (P100) and changes in epigenetic marks on histones (GCP)...
April 10, 2018: Cell Systems
https://www.readbyqxmd.com/read/29626355/formation-of-polymer-particles-by-direct-polymerization-on-the-surface-of-a-supramolecular-template
#10
Carsten Schmuck, Mao Li, Elio Zellermann
Formation of polymeric materials on the surface of supramolecular assemblies is rather challenging due to the often weak non-covalent interactions between the self-assembled template and the monomers before polymerization. We herein describe that the introduction of a supramolecular anion recognition motif, the guanidiniocarbonyl pyrrole cation (GCP), into a short Fmoc-dipeptide 1 leads to self-assembled spherical nanoparticles in aqueous solution. Onto the surface of these nanoparticles negatively charged diacetylene monomers can be attached which after UV polymerization lead to the formation of a polymer shell around the self-assembled template...
April 6, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29622010/mechanical-barriers-and-transforming-growth-factor-beta-inhibitor-on-epidural-fibrosis-in-a-rabbit-laminectomy-model
#11
Juan N Albiñana-Cunningham, Purificación Ripalda-Cemboráin, Tania Labiano, José I Echeveste, Froilán Granero-Moltó, Matías Alfonso-Olmos
BACKGROUND: TGF-β has been described as a mediator of fibrosis and scarring. Several studies achieved reduction in experimental scarring through the inhibition of TGF-β. Fibroblasts have been defined as the cell population originating fibrosis, blocking fibroblast invasion may impair epidural fibrosis appearance. For this purpose, biocompatible materials used as mechanical barriers and a TGF-β inhibitor peptide were evaluated in the reduction of epidural fibrosis. METHODS: A L6 laminectomy was performed in 40 New Zealand white rabbits...
April 5, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29600495/a-preliminary-study-of-telemedicine-for-patients-with-hepatic-glycogen-storage-disease-and-their-healthcare-providers-from-bedside-to-home-site-monitoring
#12
Irene J Hoogeveen, Fabian Peeks, Foekje de Boer, Charlotte M A Lubout, Tom J de Koning, Sebastiaan Te Boekhorst, Robert-Jan Zandvoort, Rob Burghard, Francjan J van Spronsen, Terry G J Derks
BACKGROUND: The purpose of this project was to develop a telemedicine platform that supports home site monitoring and integrates biochemical, physiological, and dietary parameters for individual patients with hepatic glycogen storage disease (GSD). METHODS AND RESULTS: The GSD communication platform (GCP) was designed with input from software developers, GSD patients, researchers, and healthcare providers. In phase 1, prototyping and software design of the GCP has occurred...
March 29, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29593827/preparation-and-applications-of-guard-cell-protoplasts-from-the-leaf-epidermis-of-solanum-lycopersicum
#13
Xuehui Yao, Wenchao Zhao, Rui Yang, Jianli Wang, Fukuan Zhao, Shaohui Wang
Background: Guard cell protoplasts (GCPs) isolated from various plants have proven to be especially useful for studies of signal transduction pathways and plant development. But it is not easy to isolate highly purified preparations of large numbers of GCPs from plants. In this research, our focus is on a method to isolate large numbers of guard cells from tomato leaves. The protocols described yield millions of highly purified, viable GCPs, which are also suitable for studies on guard cell physiology...
2018: Plant Methods
https://www.readbyqxmd.com/read/29576609/initiating-research-in-a-private-dental-practice
#14
K Hare, N Yadev, C Campbell
Research is an intrinsic part of both academia and clinical best practice. Within an academic environment, this can include access to advice and guidance from trained professionals. Similarly, while sometimes overly risk-averse, within the NHS there is a structured and systematic approach to healthcare research. However, in the UK, a large number of specialist dental procedures take place within the private healthcare system, which does not have access to such support and guidance. How, then, can we generate our own dental research from private dental primary care settings? With a number of phrases becoming part of everyday vocabulary in dental primary care, such as practice-based research, patient-centred outcomes, evidence-based dentistry, it is time to consider this...
March 23, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29531057/lateral-cerebellum-is-preferentially-sensitive-to-high-sonic-hedgehog-signaling-and-medulloblastoma-formation
#15
I-Li Tan, Alexandre Wojcinski, Harikrishna Rallapalli, Zhimin Lao, Reeti M Sanghrajka, Daniel Stephen, Eugenia Volkova, Andrey Korshunov, Marc Remke, Michael D Taylor, Daniel H Turnbull, Alexandra L Joyner
The main cell of origin of the Sonic hedgehog (SHH) subgroup of medulloblastoma (MB) is granule cell precursors (GCPs), a SHH-dependent transient amplifying population in the developing cerebellum. SHH-MBs can be further subdivided based on molecular and clinical parameters, as well as location because SHH-MBs occur preferentially in the lateral cerebellum (hemispheres). Our analysis of adult patient data suggests that tumors with Smoothened ( SMO ) mutations form more specifically in the hemispheres than those with Patched 1 ( PTCH1 ) mutations...
March 27, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29528616/photocatalytic-hydrogen-production-with-conjugated-polymers-as-photosensitizers
#16
Wen-Wen Yong, Huan Lu, Han Li, Shu Wang, Ming-Tian Zhang
Artificial photosynthesis is a chemical process that aims to capture energy from sunlight to produce solar fuels. Light absorption by a robust and efficient photosensitizer is one of the key steps in solar energy conversion. However, common photosensitizers, including [Ru(bpy)3 ]2+ (RuP), remain far from the ideal. In this work, we exploited the performance of conjugated polymers (CPs) as photosensitizers in photodriven hydrogen evolution in aqueous solution (pH 6). Interestingly, CPs, such as poly(fluorene- co-phenylene) derivative (429 mmolH2 ·gCP -1 ·h-1 ), exhibit steady and high reactivity toward hydrogen evolution; this performance can rival that of a phosphonated RuP under the same conditions, indicating that CPs are promising metal-free photosensitizers for future applications in photocatalysis...
April 4, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29521482/current-application-and-future-perspectives-of-psma-pet-imaging-in-prostate-cancer
#17
Francesco Ceci, Paolo Castellucci, Stefano Fanti
As precision medicine evolves, the contribution of molecular imaging to the management of prostate cancer (PCa) patients, especially for Positron Emission Tomography (PET) imaging, is gaining importance. Highly successful approaches to measure the expression of the prostate specific membrane antigen (PSMA) have been introduced recently. PSMA, the glutamate carboxypeptidase II (GCP-II), is a membrane bound metallo-peptidase that is overexpressed in 90-100% of PCa cells. Due to its selective over-expression, PSMA is a reliable tissue marker for prostate cancer and is considered an ideal target for tumor specific imaging and therapy...
March 8, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29506937/dual-chemotactic-factors-secreting-human-amniotic-mesenchymal-stem-cells-via-talen-mediated-gene-editing-enhanced-angiogenesis
#18
In Sil Jeong, Youngjin Park, Hyun Aae Ryu, Hyun Sook An, Ju Hye Han, Sung-Whan Kim
BACKGROUND: Even though mesenchymal stem cells (MSCs) have angiogenic property, their cytokine secretory capacity is limited to treat ischemic vascular disorders. In present study, we produced genome-edited MSCs that secreted dual chemokine granulocyte chemotactic protein-2 (GCP-2) and stromal-derived factor-1α (SDF-1α) and determined their therapeutic potential in the context of experimental ischemia. METHODS: GCP-2 and SDF-1α genes were integrated into safe harbor site at the safe harbor genomic locus of amniotic mesenchymal stem cells (AMM) via transcription activator-like effector nucleases (TALEN)...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29486765/xiangbin-prescription-for-the-recovery-of-gastrointestinal-function-after-abdominal-surgery-the-xbprs-trial-study-protocol-for-a-randomized-controlled-trial
#19
Huachan Gan, Jinxuan Lin, Zhi Jiang, Qicheng Chen, Lixing Cao, Zhiqiang Chen
BACKGROUND: Most patients who undergo abdominal surgery recover bowel movements within a week; however, some suffer prolonged intestinal paralysis or postoperative ileus (POI) leading to complications, such as infection and intestinal adhesions, which can extend hospitalization and increase readmission rates, and consequently increasing healthcare costs. Chinese medicine is effective for accelerating the recovery of gastrointestinal function after abdominal surgery. Xiangbin prescription (XBP) is the standard prescription for this purpose in our hospital; however, randomized controlled trials of it have not yet been conducted...
February 27, 2018: Trials
https://www.readbyqxmd.com/read/29451591/impact-of-aggressive-periodontitis-and-chronic-periodontitis-on-oral-health-related-quality-of-life
#20
Alexandre Hugo Llanos, Carlos Guillermo Benítez Silva, Karina Tamie Ichimura, Estela Sanches Rebeis, Marcela Giudicissi, Marcelo Munhóes Romano, Luciana Saraiva
The purpose of this cross-sectional study was to investigate the effect of different forms of periodontal diseases on Oral Health-Related Quality of Life (OHRQoL). Fifty-two patients with Aggressive Periodontitis (AP) or Chronic Periodontitis (CP) were included: nine patients with Localized Aggressive Periodontitis (LAP), thirty-three patients with Generalized Aggressive Periodontitis (GAP) and ten patients with Generalized Chronic Periodontitis (GCP). Oral Health Impact Profile questionnaires (OHIP-14) were distributed after a clinical examination that measured the following periodontal parameters: tooth loss, bleeding on probing (BoP), probing depth (PD), gingival recession (REC) and clinical attachment level (CAL)...
2018: Brazilian Oral Research
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