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https://www.readbyqxmd.com/read/29903789/prevalence-and-clustering-of-cardiovascular-risk-factors-a-cross-sectional-survey-among-nanjing-adults-in-china
#1
Xin Hong, Qing Ye, Jing He, Zhiyong Wang, Huafeng Yang, Shengxiang Qi, Xupeng Chen, Chenchen Wang, Hairong Zhou, Chao Li, Zhenzhen Qin, Fei Xu
OBJECTIVES: To estimate prevalence and clustering of cardiovascular risk factors (CRFs), and investigate the association between relevant characteristics and CRF clustering among adults in eastern China. DESIGN: Community-based cross-sectional study. SETTING: Data were collected by interview survey, physical measurements and laboratory examinations from the 2011 Nanjing Chronic Disease and Risk Factor Surveillance. PARTICIPANTS: A representative sample of 41 072 residents aged ≥18 years volunteered to participate in the survey, with a response rate of 91...
June 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29797570/emergence-of-uncommon-hiv-1-non-b-subtypes-and-circulating-recombinant-forms-and-trends-in-transmission-of-antiretroviral-drug-resistance-in-patients-with-primary-infection-during-the-2013-2015-period-in-marseille-southeastern-france
#2
Catherine Tamalet, Hervé Tissot-Dupont, Anne Motte, Christian Tourrès, Catherine Dhiver, Isabelle Ravaux, Isabelle Poizot-Martin, Thérèse Dieng, Christelle Tomei, Sylvie Bregigeon, Olivia Zaegel-Faucher, Hélène Laroche, Sarah Aherfi, Saadia Mokhtari, Hervé Chaudet, Amelie Ménard, Philippe Brouqui, Andreas Stein, Philippe Colson
Primary HIV-1 infections (PHI) with non-B subtypes are increasing in developed countries while transmission of HIV-1 harboring antiretroviral resistance-associated mutations (RAMs) remains a concern. This study assessed non-B HIV-1 subtypes and RAMs prevalence among patients with PHI in university hospitals of Marseille, Southeastern France, in 2005-2015 (11 years). HIV-1 sequences were obtained by in-house protocols from 115 patients with PHI, including 38 for the 2013-2015 period. On the basis of the phylogenetic analysis of the reverse transcriptase region, non-B subtypes were identified in 31% of these patients...
May 24, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29768661/unravelling-changing-interspecific-interactions-across-environmental-gradients-using-markov-random-fields
#3
Nicholas J Clark, Konstans Wells, Oscar Lindberg
Inferring interactions between co-occurring species is key to identify processes governing community assembly. Incorporating interspecific interactions in predictive models is common in ecology, yet most methods do not adequately account for indirect interactions (where an interaction between two species is masked by their shared interactions with a third) and assume interactions do not vary along environmental gradients. Markov random fields (MRF) overcome these limitations by estimating interspecific interactions, while controlling for indirect interactions, from multispecies occurrence data...
May 16, 2018: Ecology
https://www.readbyqxmd.com/read/29763523/role-of-basic-pentacysteiene-transcription-factors-in-a-sub-set-of-cytokinin-signaling-responses
#4
Carly M Shanks, Andreas Hecker, Chia-Yi Cheng, Luise Brand, Silvio Collani, Markus Schmid, G Eric Schaller, Dierk Wanke, Klaus Harter, Joseph J Kieber
Cytokinin plays diverse roles in plant growth and development, generally acting by modulating gene transcription in target tissues. The type-B ARR transcription factors have emerged as primary targets of cytokinin signaling and are required for essentially all cytokinin-mediated changes in gene expression. The diversity of cytokinin function is likely imparted by the activity of various transcription factors working with the type-B ARRs to alter specific sets of target genes. One potential set of co-regulators modulating the cytokinin response are the BARLEY B-RECOMBINANT/BASIC PENTACYSTEINE (BBR/BPC) family of plant-specific transcription factors...
May 15, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29762165/improved-fracture-prediction-using-different-frax-adjustments-in-hiv-infected-women
#5
Jingyan Yang, Anjali Sharma, Qiuhu Shi, Kathryn Anastos, Mardge H Cohen, Elizabeth T Golub, Deborah Gustafson, Daniel Merenstein, Wendy J Mack, Phyllis C Tien, Jeri Nieves, Michael T Yin
OBJECTIVES: A Fracture risk assessment tool (FRAX®) using clinical risk factors (CRFs) alone underestimates fracture risk in HIV-infected men. Our objective was to determine whether accuracy of FRAX would be improved by considering HIV as a cause of secondary osteoporosis, and further improved with addition of DXA parameters in HIV-infected women. DESIGN: Subgroup analysis of Women's Interagency HIV Study. METHODS: We included 1148 women (900 HIV-infected and 248 uninfected) over age 40 with data to approximate FRAX CRFs and 10-year observational data for incident fragility fractures; 181 (20%) HIV-infected women had DXA data...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29736999/the-hidden-half-ecology-and-evolution-of-cryptobenthic-fishes-on-coral-reefs
#6
Simon J Brandl, Christopher H R Goatley, David R Bellwood, Luke Tornabene
Teleost fishes are the most diverse group of vertebrates on Earth. On tropical coral reefs, their species richness exceeds 6000 species; one tenth of total vertebrate biodiversity. A large proportion of this diversity is composed of cryptobenthic reef fishes (CRFs): bottom-dwelling, morphologically or behaviourally cryptic species typically less than 50 mm in length. Yet, despite their diversity and abundance, these fishes are both poorly defined and understood. Herein we provide a new quantitative definition and synthesise current knowledge on the diversity, distribution and life history of CRFs...
May 7, 2018: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/29733056/asociaci%C3%A3-n-de-leptina-con-factores-cardiometab%C3%A3-licos-en-escolares-y-adolescentes-con-hiperplasia-suprarrenal-cong%C3%A3-nita
#7
Jessie Nallely Zurita-Cruz, Miguel Ángel Villasís-Keever, Leticia Damasio-Santana, Leticia Manuel-Apolinar, Rosalba Ferrusca-Ceja, Elisa Nishimura-Meguro, Aleida de J Rivera-Hernández, Eulalia Garrido-Magaña
Introducción: En la hiperplasia suprarrenal congénita (HSC), la obesidad, la hiperinsulinemia y los niveles de leptina se encuentran incrementados. Objetivo: Identificar la frecuencia de los factores de riesgo cardiometabólico (FRC) en niños y adolescentes con HSC y explorar la relación con los niveles de leptina. Método: Estudio transversal de 40 pacientes a quienes se realizó somatometría y evaluación de glucosa, insulina, triglicéridos, 17-hidroxiprogesterona, leptina, colesterol HDL y LDL en ayuno...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29730388/are-the-favorable-cardiovascular-outcomes-of-empagliflozin-treatment-explained-by-its-effects-on-multiple-cardiometabolic-risk-factors-a-simulation-of-the-results-of-the-empa-reg-outcome-trial
#8
Shihchen Kuo, Wen Ye, Justin Duong, William H Herman
AIMS: It is unclear whether the favorable impact of empagliflozin on cardiovascular outcomes (CVOs) is due to its effect on multiple cardiometabolic risk factors (CRFs). METHODS: We used the Michigan Model for Diabetes, a validated computer simulation model, and published data from the EMPA-REG OUTCOME trial to estimate three-year CVOs in the placebo and pooled empagliflozin treatment groups to assess whether the observed benefits might be attributable to differences in CRFs...
May 3, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29728052/a-new-method-for-the-assessment-of-endothelial-function-with-peripheral-arterial-volume
#9
Daoyuan Si, Lujia Ni, Yunfei Wang, Jinsha Liu, Jining Yang, Ping Yang
BACKGROUND: Currently, many methodological approaches have been developed to assess peripheral endothelial function. However, a development of the noninvasive and automated technique for routinely assessing endothelial function is still required. We evaluated the potential value of a new method to measure peripheral endothelial function with reactive hyperemia peripheral arterial volume (RH-PAV) in patients with chest pain. METHODS: We used a novel oximeter-like probe to detect the peripheral arterial volume (PAV) of the finger and compared it with brachial flow-mediated dilation (FMD) performed in 93 consecutive patients with chest pain...
May 4, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29724117/characterization-of-a-new-hiv-1-crf01_ae-crf07_bc-recombinant-virus-in-tianjin-china
#10
Zhehua Zhou, Ping Ma, Yi Feng, Weidong Ou, Jing Qian, Liying Gao, Defa Zhang, Yiming Shao, Min Wei
Human immunodeficiency virus (HIV) is notorious for its rapid evolving since its transmissions from money to human. Currently, HIV contains multiple subtypes, circulating recombinant forms (CRFs) and unique recombinant forms (URFs). Here, from an HIV-positive mother and her child in Tianjin, China, we identified a novel HIV-1 second-generation recombinant virus (TJ20170316 and TJ20170317) between CRF01_AE and CRF07_BC. Near full-length genomes were obtained from both samples, and they shared very close sequences, except some point mutations...
May 4, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29684083/hiv-1-transmission-networks-across-cyprus-2010-2012
#11
Leondios G Kostrikis, Johana Hezka, Dora C Stylianou, Evangelia Kostaki, Maria Andreou, Ioanna Kousiappa, Dimitrios Paraskevis, Ioannis Demetriades
A molecular epidemiology study of HIV-1 infection was conducted in one hundred diagnosed and untreated HIV-1-infected patients in Cyprus between 2010 and 2012, representing 65.4% of all the reported HIV-1 infections in Cyprus in this three-year period, using a previously defined enrolment strategy. Eighty-two patients were newly diagnosed (genotypic drug resistance testing within six months from diagnosis), and eighteen patients were HIV-1 diagnosed for a longer period or the diagnosis date was unknown. Phylogenetic trees of the pol sequences obtained in this study with reference sequences indicated that subtypes B and A1 were the most common subtypes present and accounted for 41...
2018: PloS One
https://www.readbyqxmd.com/read/29670914/association-of-wrist-circumference-and-waist-to-height-ratio-with-cardiometabolic-risk-factors-among-type-ii-diabetics-in-a-ghanaian-population
#12
Christian Obirikorang, Yaa Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Emmanuel Toboh, Evans Adu Asamoah, Bright Amakwaa, Emmanuella Nsenbah Batu, Peter Brenya
The study determined the association of wrist circumference (WrC) and waist-to-height ratio (WHtR) with cardiometabolic risk factors among diabetics in a Ghanaian population. This cross-sectional study involved 384 diabetic patients at Begoro District Hospital, Ghana. Blood pressure, anthropometrics, and biochemical indices were measured. The overall prevalence of dyslipidaemia, metabolic syndrome (MetS), and hypertension was 42.4%, 76.3%, and 39.8%, respectively. The optimum cut-off range of WrC to identify individuals at increased cardiometabolic risk was 17...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29664930/distinctive-variation-in-the-u3r-region-of-the-5-long-terminal-repeat-from-diverse-hiv-1-strains
#13
Christelle Mbondji-Wonje, Ming Dong, Xue Wang, Jiangqin Zhao, Viswanath Ragupathy, Ana M Sanchez, Thomas N Denny, Indira Hewlett
Functional mapping of the 5'LTR has shown that the U3 and the R regions (U3R) contain a cluster of regulatory elements involved in the control of HIV-1 transcription and expression. As the HIV-1 genome is characterized by extensive variability, here we aimed to describe mutations in the U3R from various HIV-1 clades and CRFs in order to highlight strain specific differences that may impact the biological properties of diverse HIV-1 strains. To achieve our purpose, the U3R sequence of plasma derived virus belonging to different clades (A1, B, C, D, F2) and recombinants (CRF02_AG, CRF01_AE and CRF22_01A1) was obtained using Illumina technology...
2018: PloS One
https://www.readbyqxmd.com/read/29624722/volumetric-bone-mineral-density-and-failure-load-of-distal-limbs-predict-incident-clinical-fracture-independent-hr-pqct-bmd-and-failure-load-predicts-incident-clinical-fracture-of-frax-and-clinical-risk-factors-among-older-men
#14
Lisa Langsetmo, Katherine W Peters, Andrew J Burghardt, Kristine E Ensrud, Howard A Fink, Peggy M Cawthon, Jane A Cauley, John T Schousboe, Elizabeth Barrett-Connor, Eric S Orwoll
Our objective was to determine the associations of peripheral bone strength and microarchitecture with incident clinical and major osteoporotic fracture among older men after adjusting for major clinical risk factors. We used a prospective cohort study design with data from 1794 men (mean age 84.4 years) in the Osteoporotic Fractures in Men (MrOS) study. Eligible men attended the year 14 visit, had high-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the distal radius and distal or diaphyseal tibia, DXA measured BMD, and were followed for mean 1...
April 6, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29622822/information-gaps-in-surveillance-data-and-effects-on-the-ghanaian-response-to-the-ebola-outbreak-in-west-africa
#15
Elizabeth A Awini, Joseph H K Bonney, Joseph A Frimpong, William K Ampofo, Kwadwo A Koram
Background: Complete and accurate information on disease occurrence is crucial for effective public health response to disease outbreaks. In response to the 2014 Ebola epidemic in West Africa, Ghana intensified surveillance for the disease across the country. However, the case definition provided by the Ministry of Health was not uniformly applied at all reporting health facilities. Objective: This paper analyses the accompanying Case Record Forms (CRFs) submitted to Noguchi Memorial Institute for Medical Research to determine its completeness and appropriateness for instituting an effective response to the epidemic...
September 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/29614609/-characteristic-analysis-of-molecular-subtypes-and-recombinant-structure-of-hiv-1-infection-in-zhejiang-province-2015
#16
Q Fan, W J Zhang, J Z Yang, L He, X B Ding, J F Zhang
Objective: To understand the molecular subtypes and recombinant structure of HIV-1 infection in Zhejiang Province. Methods: According to the method of stratified random sampling method, a total of 302 newly HIV infected people (excluding AIDS patients) were selected as the subjects of the investigation from April to June, 2015, who were all newly HIV positive patients reported in Zhejiang Province and were diagnosed as HIV positive and had not received antiretroviral treatment. Questionnaires were used to collect information such as gender, residency, marital status, route of transmission and case reporting area...
April 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29578195/assessment-of-osteoporotic-fracture-risk-in-urban-indian-population-using-quantitative-ultrasonography-frax-tool
#17
Raju Vaishya, Vipul Vijay, Amit K Agarwal, Prashant Maheshwari
Background & objectives: There have been studies around the world on the prevalence of osteoporosis and its related risk factors, but there have been limited studies on risk factors and osteoporosis in the Indian population. In this study, the incidence of osteoporosis and the associated clinical risk factors (CRFs) were studied in the urban Indian population. Methods: Bone mineral density of 445 individuals >38 yr of age using qualitative ultrasound (QUS) was assessed...
November 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29573193/importance-of-the-site-of-positive-surgical-margin-in-salvage-external-beam-radiation-therapy-for-biochemical-recurrence-of-prostate-cancer-after-radical-prostatectomy
#18
Tairo Kashihara, Satoshi Nakamura, Akihisa Wakita, Hiroyuki Okamoto, Koji Inaba, Rei Umezawa, Satoshi Shima, Keisuke Tsuchida, Kazuma Kobayashi, Kana Takahashi, Naoya Murakami, Yoshinori Ito, Hiroshi Igaki, Hiroyuki Fujimoto, Takashi Uno, Jun Itami
The aim of this study was to examine long-term outcomes in patients who received salvage radiotherapy (SRT) for biochemical recurrence (BRec) of prostate cancer after radical prostatectomy (RP). One hundred and twenty patients with prostate cancer who underwent SRT for BRec after RP without evidence of clinical disease were identified in our institution from 2002 to 2014. Prescription doses to prostate beds were 64.8 Gy with a fractional dose of 1.8 Gy in 96.7% of the patients. In three-dimensional conformal radiation therapy (3D-CRT), the seminal vesicle bed (SVB) was not included in the radiation fields...
May 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29484203/unravelling-the-complicated-evolutionary-and-dissemination-history-of-hiv-1m-subtype-a-lineages
#19
Marcel Tongo, Gordon W Harkins, Jeffrey R Dorfman, Erik Billings, Sodsai Tovanabutra, Tulio de Oliveira, Darren P Martin
Subtype A is one of the rare HIV-1 group M (HIV-1M) lineages that is both widely distributed throughout the world and persists at high frequencies in the Congo Basin (CB), the site where HIV-1M likely originated. This, together with its high degree of diversity suggests that subtype A is amongst the fittest HIV-1M lineages. Here we use a comprehensive set of published near full-length subtype A sequences and A-derived genome fragments from both circulating and unique recombinant forms (CRFs/URFs) to obtain some insights into how frequently these lineages have independently seeded HIV-1M sub-epidemics in different parts of the world...
January 2018: Virus Evolution
https://www.readbyqxmd.com/read/29439583/identification-of-a-novel-hiv-1-recombinant-form-b-c-in-men-who-have-sex-with-men-in-shaanxi-china
#20
Mengyan Zhang, Ruolei Xin, Wenhui Chang
Many new circulating recombinant forms (CRFs) and unique recombinant forms (URFs) of HIV-1 have been found in men who have sex with men (MSM) in recent years, in China. In this study, a unique HIV-1 recombinant genome (SN153) was characterized from an HIV-positive male infected through homosexual behavior in Shaanxi, China. The mosaic pattern had a complex intersubtype recombinant structure with six breakpoints, with three subtype C segments inserted into subtype B backbone. And three similar breakpoints with CRF07_BC were observed in the pol gene...
May 2018: AIDS Research and Human Retroviruses
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