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https://www.readbyqxmd.com/read/29849132/delivery-of-mitochondriotropic-doxorubicin-derivatives-using-self-assembling-hyaluronic-acid-nanocarriers-in-doxorubicin-resistant-breast-cancer
#1
Hui-Na Liu, Ning-Ning Guo, Wang-Wei Guo, Ming-Yi Huang-Fu, Mohammad Reza Vakili, Jie-Jian Chen, Wen-Hong Xu, Qi-Chun Wei, Min Han, Afsaneh Lavasanifar, Jian-Qing Gao
Breast cancer is the leading cause of cancer-related death for women, and multidrug resistance (MDR) is the major obstacle faced by chemotherapy for breast cancer. We have previously synthesized a doxorubicin (DOX) derivative by conjugating DOX with triphenylphosphonium (TPP) to achieve mitochondrial delivery, which induced higher cytotoxicity in drug-resistant breast cancer cells than DOX itself. Due to its amphiphilicity, TPP-DOX is difficult to physically entrap in nanocarriers. Thus, we linked it to hyaluronic acid (HA) by a novel ionic bond utilizing the specific bromide ion of TPP to form supra-molecular self-assembled structures (HA-ionic-TPP-DOX)...
May 31, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29803881/potential-adverse-outcome-pathway-aop-of-silver-nanoparticles-mediated-reproductive-toxicity-in-zebrafish
#2
Yan-Bo Ma, Chun-Jiao Lu, Muhammad Junaid, Pan-Pan Jia, Li Yang, Jing-Hui Zhang, De-Sheng Pei
Recently, the augmented utilization of silver nanoparticles (AgNPs) resulted in increasingrates of its release to aquatic environment, which potentially caused adverse effects to aquatic organisms. Therefore, this study investigated - reproductive toxicity and associated potential adverse outcome pathway (AOP) in zebrafish after chronic exposure to AgNPs. To serve the purpose, three-month-old adult zebrafish were exposed to different concentrations (0, 10, 33 and 100 μg/L) of AgNPs for five weeks. Exposure to 33 and 100 μg/L of AgNPs significantly decreased the fecundity in female zebrafish, accompanied by increasing apoptotic cells in the ovarian and testicular tissue using TUNEL assay...
May 11, 2018: Chemosphere
https://www.readbyqxmd.com/read/29795396/toxicity-and-transcriptome-sequencing-rna-seq-analyses-of-adult-zebrafish-in-response-to-exposure-carboxymethyl-cellulose-stabilized-iron-sulfide-nanoparticles
#3
Min Zheng, Jianguo Lu, Dongye Zhao
Increasing utilization of stabilized iron sulfides (FeS) nanoparticles implies an elevated release of the materials into the environment. To understand potential impacts and underlying mechanisms of nanoparticle-induced stress, we used the transcriptome sequencing (RNA-seq) technique to characterize the transcriptomes from adult zebrafish exposed to 10 mg/L carboxymethyl cellulose (CMC) stabilized FeS nanoparticles for 96 h, demonstrating striking differences in the gene expression profiles in liver. The exposure caused significant expression alterations in genes related to immune and inflammatory responses, detoxification, oxidative stress and DNA damage/repair...
May 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29782148/accelerated-bone-regeneration-by-nitrogen-doped-carbon-dots-functionalized-with-hydroxyapatite-nanoparticles
#4
Deepak Kumar Khajuria, Vijay Bhooshan Kumar, Dana Gigi, Aharon Gedanken, David Karasik
We investigated the osteogenic potential of nitrogen doped carbon dots (NCDs) conjugated with hydroxyapatite (HA) nanoparticles on the MC3T3-E1 osteoblast cell functions and in a zebrafish (ZF) jaw bone regeneration (JBR) model. The NCDs-HA nanoparticles were fabricated by hydrothermal cum co-precipitation technique. The surface structures of NCDs-HA nanoparticles were characterized by XRD, FTIR, UV-Vis, and laser fluorescent spectroscopy, SEM, TEM, EDS, and NMR analysis. The TEM data confirmed that the NCDs are well conjugated on the HA nanoparticle surfaces...
May 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29778081/molecular-aspect-of-silver-nanoparticles-regulated-embryonic-development-in-zebrafish-danio-rerio-by-oct-4-expression
#5
Biplab Sarkar, Suresh K Verma, Javed Akhtar, Surya Prakash Netam, Sanjay Kr Gupta, Pritam Kumar Panda, Koel Mukherjee
With the enhancement of commercial manifestation of silver nanoparticles, concerned has risen on their accumulation in aquatic system and consequent effects on fish development and metabolism. In this study, experiments were conducted to assess the impacts of silver nanoparticles on early life cycles of fish considering Zebrafish (Danio rerio) as experimental model. Silver nanoparticles were synthesized through chemical reduction method and characterized through UV-visible spectroscopy, dynamic light scattering (DLS), and HR-TEM...
May 4, 2018: Chemosphere
https://www.readbyqxmd.com/read/29760452/quantifying-compressive-forces-between-living-cell-layers-and-within-tissues-using-elastic-round-microgels
#6
Erfan Mohagheghian, Junyu Luo, Junjian Chen, Gaurav Chaudhary, Junwei Chen, Jian Sun, Randy H Ewoldt, Ning Wang
Increasing evidence shows that mechanical stresses are critical in regulating cell functions, fate, and diseases. However, no methods exist that can quantify isotropic compressive stresses. Here we describe fluorescent nanoparticle-labeled, monodisperse elastic microspheres made of Arg-Gly-Asp-conjugated alginate hydrogels (elastic round microgels, ERMGs). We generate 3D displacements and calculate strains and tractions exerted on an ERMG. Average compressive tractions on an ERMG are 570 Pa within cell layers and 360 Pa in tumor-repopulating cell (TRC) colonies grown in 400-Pa matrices...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29750032/protection-of-silver-nanoparticles-using-eysenhardtia-polystachya-in-peroxide-induced-pancreatic-%C3%AE-cell-damage-and-their-antidiabetic-properties-in-zebrafish
#7
Abraham Heriberto Garcia Campoy, Rosa Martha Perez Gutierrez, Gabriela Manriquez-Alvirde, Alethia Muñiz Ramirez
Background: The aim was to explore the efficacy of extract of Eysenhardtia polystachya -loaded silver nanoparticles (EP/AgNPs) on pancreatic β cells, INS-1 cells, and zebrafish as a valuable model for the study of diabetes mellitus. Materials and methods: EP/AgNPs were synthesized using methanol/water bark extract of E. polystachya and characterized using various physicochemical techniques. Results: Immersion of adult zebrafish in 111 mM glucose solution resulted in a sustained hyperglycemic, hyperlipidemic state, and serum insulin levels decreased...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29734649/toxicological-assessment-of-a-lignin-core-nanoparticle-doped-with-silver-as-an-alternative-to-conventional-silver-core-nanoparticles
#8
Cassandra E Nix, Bryan J Harper, Cathryn G Conner, Alexander P Richter, Orlin D Velev, Stacey L Harper
Elevated levels of silver in the environment are anticipated with an increase in silver nanoparticle (AgNP) production and use in consumer products. To potentially reduce the burden of silver ion release from conventional solid core AgNPs, a lignin-core particle doped with silver ions and surface-stabilized with a polycationic electrolyte layer was engineered. Our objective was to determine whether any of the formulation components elicit toxicological responses using embryonic zebrafish. Ionic silver and free surface stabilizer were the most toxic constituents, although when associated separately or together with the lignin core particles, the toxicity of the formulations decreased significantly...
May 4, 2018: Antibiotics
https://www.readbyqxmd.com/read/29729476/silver-nanoparticles-impair-zebrafish-skeletal-and-cardiac-myofibrillogenesis-and-sarcomere-formation
#9
Qin-Han Xu, PengPeng Guan, Ting Zhang, Chang Lu, GuoLiang Li, Jing-Xia Liu
Metal nanoparticles from industries contaminate the environment and affect the normal development of fish even human health. However, little is known about their biological effects on fish embryogenesis and the potential mechanisms. In this study, zebrafish embryos exposed to/injected with silver nanopaticles (AgNPs) exhibited shorter body, reduced heartbeats, and dysfunctional movements. Less, loose, and unassembled myofibrils were observed in AgNPs-treated embryos, and genes in myofibrillogenesis and sarcomere formation were found to be down-regulated in treated embryos...
April 30, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29715535/plant-nutraceuticals-quercetrin-and-afzelin-capped-silver-nanoparticles-exert-potent-antibiofilm-effect-against-food-borne-pathogen-salmonella-enterica-serovar-typhimurium-and-curtail-planktonic-growth-in-zebrafish-infection-model
#10
Robert Lotha, Niranjana SriSundaramoorthy, Bhanuvalli R Shamprasad, Saisubramanian Nagarajan, Aravind Sivasubramanian
Purified plant nutraceuticals afzelin and quercetrin from an edible plant- Crotolaria tetragona was employed for the fabrication of silver nanoparticles (AgNPs) by a sunlight mediated process. From among a panel of strains tested, AgNPs displayed potent bacteriostatic and bactericidal effect against P. aeruginosa and S. typhimurium. Time kill studies revealed green synthesized AgNPs displayed comparable bactericidal effect with chemically synthesized AgNPs against S. typhimurium. Antibiofilm potential of AgNPs showed that they were highly effective at sub MIC concentrations in causing 50% biofilm inhibition against food borne pathogen S...
April 28, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29710581/interaction-of-carboxylated-cdse-zns-quantum-dots-with-fish-embryos-towards-understanding-of-nanoparticles-toxicity
#11
Ričardas Rotomskis, Živilė Jurgelėnė, Mantas Stankevičius, Milda Stankevičiūtė, Nijolė Kazlauskienė, Kęstutis Jokšas, Danguolė Montvydienė, Vytautas Kulvietis, Vitalijus Karabanovas
Due to colloidal instability even with protective coatings, nanoparticles tend to aggregate in complex environments and possibly interact with biota. In this study, visualization of quantum dots (QDs) interaction with rainbow trout (Oncorhynchus mykiss) embryos was performed. Studies on zebrafish (Danio rerio) and pearl gourami (Trichogaster leerii) embryos have shown that QDs interact with embryos in a general manner and their affects are independent on the type of the embryo. It was demonstrated that carboxylated CdSe/ZnS QDs (4 nM) were aggregating in accumulation media and formed agglomerates on the surface of fish embryos under 1-12 days incubation in deep-well water...
September 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29709808/uptake-of-bde-209-on-zebrafish-embryos-as-affected-by-sio-2-nanoparticles
#12
Shu-Ju Chao, C P Huang, Pei-Chung Chen, Shih-Hsien Chang, Chihpin Huang
It was hypothesized that interactions between emerging contaminants such as decabromodiphenyl ether (BDE-209) and nanoparticles (NPs) such as nano-SiO2 (nSiO2 ), can affect contaminant transport in the aquatic environment and its ecotoxicity. This study assessed the influence of nSiO2 on the uptake of BDE-209 by zebrafish embryo. The distribution of BDE-209 and nSiO2 on the external chorion and the internal embryo mass (i.e., dechorionated embryo) was measured. For single exposure of nSiO2 to zebrafish embryo, separately, results showed that nSiO2 accumulation on the chorion surface was higher than that in the dechorionated embryo...
August 2018: Chemosphere
https://www.readbyqxmd.com/read/29697962/synergistic-toxicity-produced-by-mixtures-of-biocompatible-gold-nanoparticles-and-widely-used-surfactants
#13
Aurora L Ginzburg, Lisa Truong, Robert L Tanguay, James E Hutchison
Nanoparticle safety is usually determined using solutions of individual particles that are free of additives. However, the size-dependent properties of nanoparticles can be readily altered through interactions with other components in a mixture. In applications, nanoparticles are commonly combined with surfactants or other additives to increase dispersion or to enhance product performance. Surfactants might also influence the biological activity of nanoparticles; however, little is known about such effects...
May 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29696335/an-effective-established-biosensor-of-bifunctional-probes-labeled-aunps-combined-with-lamp-for-detection-of-fish-pathogen-streptococcus-iniae
#14
Ya Zhou, Jingfan Xiao, Xin Ma, Qiyao Wang, Yuanxing Zhang
In purpose of valid Streptococcus iniae detection, we established a colorimetric biosensor using gold nanoparticles (AuNPs) labeled with dual functional probes and along with loop-mediated isothermal amplification (LAMP) assay (LAMP-AuNPs). Based on the characteristics of self-aggregation and bio-conjugation with ligands, AuNPs were chosen for observable color change in tandem with LAMP amplification method to reach high sensitivity and easy operation. Meanwhile, the improvement of dual probes that could fully utilize the LAMP product gave the biosensor a stable result exhibition...
June 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29684426/mitochondria-targeting-nanomedicine-an-effective-and-potent-strategy-against-aminoglycosides-induced-ototoxicity
#15
Shuang Zhou, Yanhui Sun, Xiao Kuang, Shanshan Hou, YinXian Yang, Zhenjie Wang, Hongzhuo Liu
We report a proof-of-concept for the development of mitochondria-targeting nanoparticles (NPs) loaded with geranylgeranylacetone (GGA) to protect against a wide range of gentamicin-induced ototoxicity symptoms in a zebrafish model. The polymeric NPs were functionalized with a mitochondrial-homing peptide (d‑Arg‑Dmt‑Orn‑Phe‑NH2 ) and exhibited greater mitochondrial uptake and lower gentamicin uptake in hair cells via mechanotransduction (MET) channels and tuned machinery in the hair bundle than the ordinary NPs did...
April 21, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29674092/humic-acid-attenuation-of-silver-nanoparticle-toxicity-by-ion-complexation-and-the-formation-of-a-ag-3-coating
#16
Paolin Rocio Cáceres-Vélez, Maria Luiza Fascineli, Marcelo Henrique Sousa, Cesar Koppe Grisolia, Luis Yate, Paulo Eduardo Narcizo de Souza, Irina Estrela-Lopis, Sergio Moya, Ricardo Bentes Azevedo
The use of silver nanoparticles (AgNPs) result in an inevitable contact with aquatic environments. Here we study the behavior of AgNPs and the developmental toxicity in zebrafish embryos exposed to these nanoparticles (0-10 mg/L) with and without the presence of HA (20 mg/L), using zebrafish facility water (ZFW) and zebrafish growing media (ZGM). The presence of cations and HA gave rise to a decrease in Ag ion release and ζ-potential, an increase in the hydrodynamic diameter and oxidation of the AgNP surface...
April 11, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29658397/inflammation-coagulation-response-and-thrombotic-effects-induced-by-silica-nanoparticles-in-zebrafish-embryos
#17
Junchao Duan, Shuang Liang, Yang Yu, Yang Li, Lijing Wang, Zehao Wu, Yueyue Chen, Mark R Miller, Zhiwei Sun
Nowadays, nanotechnology environmental health and safety (nanoEHS) is gaining attention. We previously found that silica nanoparticles (SiNPs) could induce vascular endothelial damage. However, the subsequent toxicologic response to SiNPs-induced endothelial damage was still largely unknown. In this study, we explored the inflammation-coagulation response and thrombotic effects of SiNPs in endothelial cells and zebrafish embryos. For in vitro study, swollen mitochondria and autophagosome were observed in ultrastructural analysis...
June 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29656436/comparative-analysis-of-the-toxicity-of-gold-nanoparticles-in-zebrafish
#18
Srinath Patibandla, Yinan Zhang, Ali Mohammad Tohari, Peng Gu, James Reilly, Yu Chen, Xinhua Shu
The use of nanoparticles - particles that range in size from 1 to 100 nm - has become increasingly prevalent in recent years, bringing with it a variety of potential toxic effects. Zebrafish embryos were exposed during the 3 day postfertilization period to gold nanospheres (GNSs), gold nanorods (GNRs), GNRs coated with polystyrene sulphate (PSS-GNRs) and GNRs coated with both PSS and polyallamine hydrochloride (PAH-PSS-GNRs). All nanorods were stabilized with cetyltrimethylammonium bromide. GNSs were the least toxic of the nanoparticles studied, with exposure resulting in no significant changes in mortality, hatching or heart rate...
April 15, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29656193/trade-offs-in-ecosystem-impacts-from-nanomaterial-versus-organic-chemical-ultraviolet-filters-in-sunscreens
#19
David Hanigan, Lisa Truong, Jared Schoepf, Takayuki Nosaka, Anjali Mulchandani, Robert L Tanguay, Paul Westerhoff
Both nanoparticulate (nZnO and nTiO2 ) and organic chemical ultraviolet (UV) filters are active ingredients in sunscreen and protect against skin cancer, but limited research exists on the environmental effects of sunscreen release into aquatic systems. To examine the trade-offs of incorporating nanoparticles (NPs) into sunscreens over the past two decades, we targeted endpoints sensitive to the potential risks of different UV filters: solar reactive oxygen production in water and disruption of zebrafish embryo development...
August 1, 2018: Water Research
https://www.readbyqxmd.com/read/29656190/effect-of-titanium-dioxide-nanoparticles-on-the-bioavailability-and-neurotoxicity-of-cypermethrin-in-zebrafish-larvae
#20
Meng Li, Qiong Wu, Qiangwei Wang, Dandan Xiang, Guonian Zhu
In aquatic environment, the presence of nanoparticles (NPs) has been reported to modify the bioavailability and toxicity of the organic toxicants. Nevertheless, the combined toxicity of NPs and the pesticides that were used world-widely still remains unclear. Cypermethrin (CYP), a synthetic pyrethroid insecticide, is commonly used for controlling agricultural and indoor pests. Therefore, the effects of titanium dioxide NPs (nTiO2 ) on CYP bioconcentration and its effects on the neuronal development in zebrafish were investigated in our study...
June 2018: Aquatic Toxicology
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