keyword
MENU ▼
Read by QxMD icon Read
search

Zebrafish nanoparticle

keyword
https://www.readbyqxmd.com/read/27918645/redox-and-ph-dual-responsive-polymer-based-nanoparticles-for-in-vivo-drug-delivery
#1
Chung Yen Ang, Si Yu Tan, Cathleen Teh, Jia Min Lee, Mun Fei Eddy Wong, Qiuyu Qu, Li Qing Poh, Menghuan Li, Yuanyuan Zhang, Vladimir Korzh, Yanli Zhao
Responsive nanomaterials have emerged as promising candidates as drug delivery vehicles in order to address biomedical diseases such as cancer. In this work, polymer-based responsive nanoparticles prepared by a supramolecular approach are loaded with doxorubicin (DOX) for the cancer therapy. The nanoparticles contain disulfide bonds within the polymer network, allowing the release of the DOX payload in a reducing environment within the endoplasm of cancer cells. In addition, the loaded drug can also be released under acidic environment...
December 5, 2016: Small
https://www.readbyqxmd.com/read/27915140/two-zinc-aminoclays-in-vitro-cytotoxicity-assessment-in-hela-cells-and-in-vivo-embryotoxicity-assay-in-zebrafish
#2
Hang-Suk Chun, Duckshin Park, Song Eun Lim, Kwang-Hun Jeong, Ji-Seon Park, Han-Jin Park, Shinyoung Kang, Kyoung Suk Kang, Hyun Gyu Park, Ha-Rim An, Yun Suk Huh, Young-Chul Lee
Two zinc-aminoclays [ZnACs] with functionalized primary amines [(-CH2)3NH2] were prepared by a simple sol-gel reaction using cationic metal precursors of ZnCl2 and Zn(NO3)2 with 3-aminopropyl triethoxysilane [APTES] under ambient conditions. Due to the facile interaction of heavy metals with primary amine sites and Zn-related intrinsic antimicrobial activity, toxicity assays of ZnACs nanoparticles (NPs) prior to their environmental and human-health applications are essential. However, such reports remain rare...
December 1, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27872490/use-of-zebrafish-larvae-as-a-multi-endpoint-platform-to-characterize-the-toxicity-profile-of-silica-nanoparticles
#3
Duc-Hung Pham, Bert De Roo, Xuan-Bac Nguyen, Mattias Vervaele, Angela Kecskés, Annelii Ny, Daniëlle Copmans, Hanne Vriens, Jean-Pierre Locquet, Peter Hoet, Peter A M de Witte
Nanomaterials are being extensively produced and applied in society. Human and environmental exposures are, therefore, inevitable and so increased attention is being given to nanotoxicity. While silica nanoparticles (NP) are one of the top five nanomaterials found in consumer and biomedical products, their toxicity profile is poorly characterized. In this study, we investigated the toxicity of silica nanoparticles with diameters 20, 50 and 80 nm using an in vivo zebrafish platform that analyzes multiple endpoints related to developmental, cardio-, hepato-, and neurotoxicity...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27836271/glutathione-and-zebrafish-old-assays-to-address-a-current-issue
#4
Andrey Massarsky, Jordan S Kozal, Richard T Di Giulio
Several xenobiotic agents (e.g. metals, polycyclic aromatic hydrocarbons, nanoparticles, etc.) commonly involve the generation of reactive oxygen species (ROS) and oxidative stress as part of their toxic mode of action. Among piscine models, the zebrafish is a popular vertebrate model to study toxicity of various xenobiotic agents. Similarly to other vertebrates, zebrafish possess an extensive antioxidant system, including the reduced form of glutathione (GSH), which is an important antioxidant that acts alone or in conjunction with enzymes, such as glutathione peroxidase (GPx)...
November 8, 2016: Chemosphere
https://www.readbyqxmd.com/read/27831560/manipulating-the-air-filled-zebrafish-swim-bladder-as-a-neutrophilic-inflammation-model-for-acute-lung-injury
#5
Yuefei Zhang, Hongcui Liu, Junlin Yao, Yanfeng Huang, Shenlu Qin, Zheng Sun, Yingchun Xu, Shu Wan, Hongqiang Cheng, Chunqi Li, Xue Zhang, Yuehai Ke
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are life-threatening diseases that are associated with high mortality rates due to treatment limitations. Neutrophils play key roles in the pathogenesis of ALI/ARDS by promoting the inflammation and injury of the alveolar microenvironment. To date, in vivo functional approaches have been limited by the inaccessibility to the alveolar sacs, which are located at the anatomical terminal of the respiratory duct in mammals...
November 10, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27826026/chitosan-nanoparticles-and-their-tween-80-modified-counterparts-disrupt-the-developmental-profile-of-zebrafish-embryos
#6
Zhongyue Yuan, Ying Li, Yulan Hu, Jian You, Kazuma Higashisaka, Kazuya Nagano, Yasuo Tsutsumi, Jianqing Gao
Chitosan nanoparticles (CS-NPs) and their Tween 80 modified counterparts (TmCS-NPs) are among the most commonly used brain-targeted vehicles. However, their potential developmental toxicity is poorly understood. In this study, zebrafish embryos are introduced as an in vivo platform. Both NPs showed a dose-dependent increase in developmental toxicity (decreased hatching rate, increased mortality and incidences of malformation). Neurobehavioral changes included decreased spontaneous movement in TmCS-NP treated embryos and hyperactive effect in CS-NP treated larvae...
November 5, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27798195/diet-sourced-carbon-based-nanoparticles-induce-lipid-alterations-in-tissues-of-zebrafish-danio-rerio-with-genomic-hypermethylation-changes-in-brain
#7
Eva Gorrochategui, Junyi Li, Nigel J Fullwood, Guang-Guo Ying, Meiping Tian, Li Cui, Heqing Shen, Sílvia Lacorte, Romà Tauler, Francis L Martin
With rising environmental levels of carbon-based nanoparticles (CBNs), there is an urgent need to develop an understanding of their biological effects in order to generate appropriate risk assessment strategies. Herein, we exposed zebrafish via their diet to one of four different CBNs: C60 fullerene (C60), single-walled carbon nanotubes (SWCNT), short multi-walled carbon nanotubes (MWCNTs) or long MWCNTs. Lipid alterations in male and female zebrafish were explored post-exposure in three target tissues (brain, gonads and gastrointestinal tract) using 'omic' procedures based in liquid chromatography coupled with mass spectrometry (LC-MS) data files...
October 26, 2016: Mutagenesis
https://www.readbyqxmd.com/read/27797177/one-pot-microwave-synthesis-of-water-dispersible-high-fluorescence-silicon-nanoparticles-and-their-imaging-applications-in-vitro-and-in-vivo
#8
Hong-Li Ye, Shi-Jiao Cai, Si Li, Xi-Wen He, Wen-You Li, Yu-Hao Li, YuKui Zhang
Silicon nanoparticles (SiNPs) have been reported to be synthesized by microwave-assisted method under high pressure. However, there is still a lack of knowledge about the synthesis of SiNPs via microwave-assisted method under normal pressure. Here we developed a new facile one-pot microwave-assisted synthesis method of the excellent water-soluble SiNPs (~ 4.2 nm) under normal pressure by employing glycerol as the solvent. Meanwhile, glycerol might be responsible for the photoluminescence quantum yield (PLQY) value of the resultant SiNPs up to 47% for its nature of the organic solvent to contribute to yield less surface defects of the nanoparticles than those of being prepared in aqueous solution and thus to improve the fluorescent efficiency...
October 31, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27780087/surface-modification-of-nanostructure-lipid-carrier-nlc-by-oleoyl-quaternized-chitosan-as-a-mucoadhesive-nanocarrier
#9
Jakarwan Yostawonkul, Suvimol Surassmo, Tawin Iempridee, Wittaya Pimtong, Kunat Suktham, Warayuth Sajomsang, Pattarapond Gonil, Uracha Rungsardthong Ruktanonchai
A nanostructure lipid carrier (NLC) composed of solid, and liquid lipid as a core has been developed as a delivery system for hydrophobic drug molecules. The aim of this research was to fabricate an oleoyl-quaternized-chitosan (CS)-coated NLC, where the mucoadhesive property of nanoparticles is enhanced for more efficient drug delivery. NLC loaded with alpha-mangostin (AP), a model hydrophobic drug, were fabricated using a high pressure homogenization process and subsequently coated with CS. The fabricated nanoparticles showed particle sizes in the range of 200-400nm, with low polydispersity, high physical stability and excellent encapsulation efficiency (EE>90%)...
September 29, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27771568/effect-of-surfactant-in-mitigating-cadmium-oxide-nanoparticle-toxicity-implications-for-mitigating-cadmium-toxicity-in-environment
#10
Sricharani Rao Balmuri, Uthra Selvaraj, Vadivel Vinod Kumar, Savarimuthu Philip Anthony, Aristides Michael Tsatsakis, Kirill Sergeevich Golokhvast, Thiagarajan Raman
Cadmium (Cd), classified as human carcinogen, is an extremely toxic heavy metal pollutant, and there is an increasing environmental concern for cadmium exposure through anthropogenic sources including cigarette smoke. Though Cd based nanoparticles such as cadmium oxide (CdO) are being widely used in a variety of clinical and industrial applications, the toxicity of CdO nanoparticles has not been well characterized. Herein we report the toxicity of CdO nanoparticles employing zebrafish as a model. Two different CdO nanoparticles were prepared, calcination of Cd(OH)2 without any organic molecule (CdO-1) and calcination of Cd-citrate coordination polymer (CdO-2), to evaluate and compare the toxicity of these two different CdO nanoparticles...
January 2017: Environmental Research
https://www.readbyqxmd.com/read/27720925/broadening-the-antibacterial-spectrum-of-histidine-kinase-autophosphorylation-inhibitors-via-the-use-of-%C3%AE%C2%B5-poly-l-lysine-capped-mesoporous-silica-based-nanoparticles
#11
Nadya Velikova, Nuria Mas, Laura Miguel-Romero, Lorena Polo Aguado, Ellen Stolte, Edoardo Zaccaria, Rui Cao, Nico Taverne, José Ramón Murguía, Ramon Martinez-Manez, Alberto Marina, Jerry Wells
Two-component systems (TCS) regulate diverse processes such as virulence, stress responses, metabolism and antibiotic resistance in bacteria but are absent in humans, making them promising targets for novel antibacterials. By incorporating recently described TCS histidine kinase autophosphorylation inhibitors (HKAIs) into ε-poly-L-lysine capped nanoparticles (NPs) we could overcome the Gram negative (Gr-) permeability barrier for the HKAIs. The observed bactericidal activity against Gr- bacteria was shown to be due to the enhanced delivery and internalization of the HKAIs and not an inhibitory or synergistic effect of the NPs...
October 5, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27720543/colloidal-properties-and-stability-of-aqueous-suspensions-of-few-layer-graphene-importance-of-graphene-concentration
#12
Yu Su, Guoqing Yang, Kun Lu, Elijah J Petersen, Liang Mao
Understanding the colloidal stability of graphene is essential for predicting its transport and ecological risks in aquatic environments. We investigated the agglomeration of (14)C-labeled few-layer graphene (FLG) at concentrations spanning nearly four orders of magnitude (2 μg/L to 10 mg/L) using dynamic light scattering and sedimentation measurements. FLG agglomerates formed rapidly in deionized water at concentrations >3 mg/L. From 1 mg/L to 3 mg/L, salt-induced agglomeration was decreased with dilution of FLG suspensions; the critical coagulation concentration of the more concentrated suspension (3 mg/L) was significantly lower than the dilute suspension (1 mg/L) in the presence of NaCl (1...
January 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27693782/differentially-transcriptional-regulation-on-cell-cycle-pathway-by-silver-nanoparticles-from-ionic-silver-in-larval-zebrafish-danio-rerio
#13
Jae Soon Kang, Jinjong Bong, Jin-Soo Choi, Theodore B Henry, June-Woo Park
Silver nanoparticles (AgNPs) have a strong antibacterial activity and the relevant modes of actions have regarded as direct or indirect causes of toxicity observed in the environment. In this study, the transcriptomic profiles in larval zebrafish (Danio rerio) exposed to AgNPs (about 50 nm in size) and AgNO3 as a comparative ionic silver were investigated and analyzed using differential expressed gene (DEG), Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathway analyses. Results indicated that underlying molecular mechanisms are different each other...
October 28, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27670289/plga-nanoparticles-for-intravitreal-peptide-delivery-optimization-characterization-and-toxicity-evaluation
#14
Rohit Bisht, Ilva D Rupenthal
Frequent intravitreal injections are currently used to overcome the ocular barriers and provide sufficient drug to the posterior eye segment. However, intravitreal injections have been associated with a number of complications and high treatment costs. To overcome these limitations, peptide-loaded poly(d,l-lactic-co-glycolic acid) nanoparticles (PLGA NPs) were developed using the nanoprecipitation technique and were optimized via Box-Behnken Design (BBD) and Response Surface Methodology (RSM). Developed NPs were evaluated for potential toxicity and cell apoptosis using the zebrafish embryo toxicity (ZET) model with titanium dioxide NPs and ethanol (1% v/v) serving as positive controls...
September 27, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27626946/curcumin-encapsulated-into-methoxy-poly-ethylene-glycol-poly-%C3%AE%C2%B5-caprolactone-nanoparticles-increases-cellular-uptake-and-neuroprotective-effect-in-glioma-cells
#15
Gregory Marslin, Bruno Filipe Carmelino Cardoso Sarmento, Gregory Franklin, José Alberto Ribeiro Martins, Carlos Jorge Ribeiro Silva, Andreia Ferreira Castro Gomes, Marisa Passos Sárria, Olga Maria Fernandes Pereira Coutinho, Alberto Carlos Pires Dias
Curcumin is a natural polyphenolic compound isolated from turmeric (Curcuma longa) with well-demonstrated neuroprotective and anticancer activities. Although curcumin is safe even at high doses in humans, it exhibits poor bioavailability, mainly due to poor absorption, fast metabolism, and rapid systemic elimination. To overcome these issues, several approaches, such as nanoparticle-mediated targeted delivery, have been undertaken with different degrees of success. The present study was conducted to compare the neuroprotective effect of curcumin encapsulated in poly(ε-caprolactone) and methoxy poly(ethylene glycol) poly(ε-caprolactone) nanoparticles in U251 glioblastoma cells...
September 14, 2016: Planta Medica
https://www.readbyqxmd.com/read/27615739/combined-tumor-and-neovascular-dual-targeting-gene-chemo-therapy-suppresses-tumor-growth-and-angiogenesis
#16
Bei Xu, Quansheng Jin, Jun Zeng, Ting Yu, Yan Chen, Shuangzhi Li, Daoqiong Gong, Lili He, Xiaoyue Tan, Li Yang, Gu He, Jinhui Wu, Xiangrong Song
A rational combination is critical to achieve efficiently synergistic therapeutic efficacy for tumor treatment. Hence, we designed novel antitumor combinations (T-NPs) by integrating the tumor vascular and tumor cells dual-targeting ligand with antiangiogenesis/antitumor agents. The truncated bFGF peptide (tbFGF), which could effectively bind to FGFR1 overexpressed on tumor neovasculature endothelial cells and tumor cells, was selected to modify PLGA nanoparticles (D/P-NPs) simultaneously loaded with PEDF gene and paclitaxel in this study...
October 5, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27593282/effects-of-zno-nanoparticles-on-perfluorooctane-sulfonate-induced-thyroid-disrupting-on-zebrafish-larvae
#17
Jia Du, Shutao Wang, Hong You, Zhongqiang Liu
Perfluorooctane sulfonate (PFOS) and ZnO nanoparticles (nano-ZnO) are widely distributed in the environment. However, the potential toxicity of co-exposure to PFOS and nano-ZnO remains to be fully elucidated. The test investigated the effects of co-exposure to PFOS and nano-ZnO on the hypothalamic-pituitary-thyroid (HPT) axis in zebrafish. Zebrafish embryos were exposed to a combination of PFOS (0.2, 0.4, 0.8mg/L) and nano-ZnO (50mg/L) from their early stages of life (0-14days). The whole-body content of TH and the expression of genes and proteins related to the HPT axis were analyzed...
September 2016: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/27570552/silica-nanoparticles-target-a-wnt-signal-transducer-for-degradation-and-impair-embryonic-development-in-zebrafish
#18
Hongyang Yi, Zhuyao Wang, Xiaojiao Li, Min Yin, Lihua Wang, Ali Aldalbahi, Nahed Nasser El-Sayed, Hui Wang, Nan Chen, Chunhai Fan, Haiyun Song
Many types of biocompatible nanomaterials have proven of low cytotoxicity and hold great promise for various applications in nanomedicine. Whereas they generally do not cause apparent organ toxicity or tissue damage in adult animals, it is yet to determine their biological consequences in more general contexts. In this study, we investigate how silica nanoparticles (NPs) affect cellular activities and functions under several physiological or pathological conditions. Although silica NPs are generally regarded as "inert" nanocarriers and widely employed in biomedical studies, we find that they actively affect Wnt signaling in various types of cell lines, diminishing its anti-adipogenic effect in preadipocytes and pro-invasive effect in breast cancer cells, and more significantly, impair Wnt-regulated embryonic development in Zebrafish...
2016: Theranostics
https://www.readbyqxmd.com/read/27544212/zebrafish-a-complete-animal-model-to-enumerate-the-nanoparticle-toxicity
#19
REVIEW
Chiranjib Chakraborty, Ashish Ranjan Sharma, Garima Sharma, Sang-Soo Lee
Presently, nanotechnology is a multi-trillion dollar business sector that covers a wide range of industries, such as medicine, electronics and chemistry. In the current era, the commercial transition of nanotechnology from research level to industrial level is stimulating the world's total economic growth. However, commercialization of nanoparticles might offer possible risks once they are liberated in the environment. In recent years, the use of zebrafish (Danio rerio) as an established animal model system for nanoparticle toxicity assay is growing exponentially...
2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27537402/montmorillonite-clay-alters-toxicity-of-silver-nanoparticles-in-zebrafish-danio-rerio-eleutheroembryo
#20
Govind Sharan Gupta, Alok Dhawan, Rishi Shanker
An exponential development in the use of silver nanoparticles (AgNPs) in consumer products has accelerated their release in aquatic environment. As the AgNPs enters into the aquatic systems, their fate may change due to interactions with abiotic (e.g. clay particles) or biotic factors. The abundantly present clay particles are expected to more prone for interaction with nanoparticles in aquatic systems. In the present study, it is demonstrated that AgNPs interacts with clay particles and forms heteroagglomerates...
November 2016: Chemosphere
keyword
keyword
116537
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"