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Zebrafish nanoparticle

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https://www.readbyqxmd.com/read/29227944/effects-of-starch-coating-of-magnetite-nanoparticles-on-cellular-uptake-toxicity-and-gene-expression-profiles-in-adult-zebrafish
#1
Min Zheng, Jianguo Lu, Dongye Zhao
Engineered magnetite nanoparticles (Fe3O4 NPs) have been used in many fields. To prevent particle agglomeration, stabilizers or coatings are often required. While such coatings have been shown to enhance performances, the environmental impact or toxicity of stabilized or coated Fe3O4 NPs remain poorly understood. In an effort to understand the impacts of such coatings on the toxicity of Fe3O4 NPs, we used the transcriptome sequencing (RNA-seq) technique to characterize the gill and liver transcriptomes from adult zebrafish when exposed to bare and starch-stabilized Fe3O4 NPs for 7days, demonstrating remarkable differences in gene expression profiles, also known as differentially expressed genes (DEGs) profiles, in both tissues...
December 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29214897/ss-31-peptide-enables-mitochondrial-targeting-drug-delivery-a-promising-therapeutic-alteration-to-prevent-hair-cell-damage-from-aminoglycosides
#2
Xiao Kuang, Shuang Zhou, Weiling Guo, Zhenjie Wang, Yanhui Sun, Hongzhuo Liu
Aminoglycoside-induced hearing loss stems from damage or loss of mechanosensory hair cells in the inner ear. Intrinsic mitochondrial cell death pathway plays a key role in that cellular dysfunction for which no proven effective therapies against oto-toxicities exist. Therefore, the aim of the present study was to develop a new mitochondrial targeting drug delivery system (DDS) that provided improved protection from gentamicin. Particularly, SS-31 peptide-conjugated geranylgeranylacetone (GGA) loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles were constructed successfully via emulsion-solvent evaporation method...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29197232/uptake-tissue-distribution-and-toxicity-of-polystyrene-nanoparticles-in-developing-zebrafish-danio-rerio
#3
Jordan A Pitt, Jordan S Kozal, Nishad Jayasundara, Andrey Massarsky, Rafael Trevisan, Nick Geitner, Mark Wiesner, Edward D Levin, Richard T Di Giulio
Plastic pollution is a critical environmental concern and comprises the majority of anthropogenic debris in the ocean, including macro, micro, and likely nanoscale (less than 100nm in at least one dimension) plastic particles. While the toxicity of macroplastics and microplastics is relatively well studied, the toxicity of nanoplastics is largely uncharacterized. Here, fluorescent polystyrene nanoparticles (PS NPs) were used to investigate the potential toxicity of nanoplastics in developing zebrafish (Danio rerio), as well as to characterize the uptake and distribution of the particles within embryos and larvae...
November 24, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29190539/dysbiosis-of-gut-microbiota-by-chronic-coexposure-to-titanium-dioxide-nanoparticles-and-bisphenol-a-implications-for-host-health-in-zebrafish
#4
Lianguo Chen, Yongyong Guo, Chenyan Hu, Paul K S Lam, James C W Lam, Bingsheng Zhou
Gut microbiota is of critical relevance to host health. However, toxicological understanding of environmental pollutants on gut microbiota is limited, not to mention their combined effects. In the present study, adult zebrafish (Danio rerio) were exposed to titanium dioxide nanoparticles (nano-TiO2; 100 μg/L), bisphenol A (BPA; 0, 2, and 20 μg/L) or their binary mixtures for three months. Sequencing of 16S rRNA amplicons found that nano-TiO2 and BPA coexposure shifted the intestinal microbial community, interacting in an antagonistic manner when the BPA concentration was low but in a synergistic manner at a higher BPA concentration...
November 27, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29176605/mechanistic-insight-to-ros-and-apoptosis-regulated-cytotoxicity-inferred-by-green-synthesized-cuo-nanoparticles-from-calotropis-gigantea-to-embryonic-zebrafish
#5
Puja Kumari, Pritam Kumar Panda, Ealisha Jha, Khushboo Kumari, Kumari Nisha, M Anwar Mallick, Suresh K Verma
With the rapid development of nanotechnology, much has been anticipated with copper oxide nanoparticles (CuO NP) due to their extensive industrial and commercial application. However, it has raised concern over the environmental safety and human health effects. In this study, CuO nanoparticles were synthesized using the green method with floral extract of Calotropis gigantea and characterized by standard physiochemical techniques like DLS, Zeta potential determination, UV- Visible Spectroscopy, XRD, FTIR, FESEM, and TEM...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150731/cellular-and-molecular-responses-of-adult-zebrafish-after-exposure-to-cuo-nanoparticles-or-ionic-copper
#6
Unai Vicario-Parés, Jose M Lacave, Paul Reip, Miren P Cajaraville, Amaia Orbea
Due to their antimicrobial, electrical and magnetic properties, copper nanoparticles (NPs) are suitable for a vast array of applications. Copper can be toxic to biota, making it necessary to assess the potential hazard of copper nanomaterials. Zebrafish (Danio rerio) were exposed to 10 µg Cu/L of CuO NPs of ≈100 nm (CuO-poly) or ionic copper to compare the effects provoked after 3 and 21 days of exposure and at 6 months post-exposure (mpe). At 21 days, significant copper accumulation was only detected in fish exposed to ionic copper...
November 17, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/29117438/metallic-nano-composite-toxicity-evaluation-by-zebrafish-embryo-toxicity-test-with-identification-of-specific-exposure-biomarkers
#7
Roberta Pecoraro, Antonio Salvaggio, Fabio Marino, Gianfranco Di Caro, Fabiano Capparucci, Bianca Maria Lombardo, Giuseppina Messina, Elena Maria Scalisi, Maurizio Tummino, Francesco Loreto, Giusi D'Amante, Roberto Avola, Daniele Tibullo, Maria Violetta Brundo
Nanomaterials (NM) have different shapes and can be composed of different materials such as carbon, silicon, and some metals like gold, silver, and titanium. They are used as fillers, catalysts, semiconductors, cosmetics, drug carriers in medicine, energy storage systems, and antifriction coatings. NM are the parent compounds of nanoparticles (NPs), which may be divided into two groups: fullerenes and engineered nanoparticles (ENPs). After crossing the cell membrane, NPs may be stored in vesicles, mitochondria, and additional organelles within epithelial cells...
November 8, 2017: Current Protocols in Toxicology
https://www.readbyqxmd.com/read/29113114/a-novel-experimental-and-modelling-strategy-for-nanoparticle-toxicity-testing-enabling-the-use-of-small-quantities
#8
Marinda van Pomeren, Willie J G M Peijnenburg, Nadja R Brun, Martina G Vijver
Metallic nanoparticles (NPs) differ from other metal forms with respect to their large surface to volume ratio and subsequent inherent reactivity. Each new modification to a nanoparticle alters the surface to volume ratio, fate and subsequently the toxicity of the particle. Newly-engineered NPs are commonly available only in low quantities whereas, in general, rather large amounts are needed for fate characterizations and effect studies. This challenge is especially relevant for those NPs that have low inherent toxicity combined with low bioavailability...
November 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29066782/altered-physiochemical-properties-in-industrially-synthesized-zno-nanoparticles-regulate-oxidative-stress-induce-in-vivo-cytotoxicity-in-embryonic-zebrafish-by-apoptosis
#9
Suresh K Verma, Pritam Kumar Panda, Ealisha Jha, Mrutyunjay Suar, S K S Parashar
This study investigates the in vivo cytotoxicity of ZnO nanoparticles synthesized at industrial scale with embryonic Zebrafish. Industrial synthesis of ZnO nanoparticles was mimicked at lab scale by high energy ball milling technique by milling bulk ZnO particles for 15 h. Synthesized 7 h and 10 h ZnO nanoparticles showed significant alteration of size, zeta potential and optical properties in comparison to Bulk ZnO. Mortality and hatching rate in Zebrafish embryos were influenced by these alterations...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29058062/comparison-of-dissolved-nickel-and-nickel-nanoparticles-toxicity-in-larval-zebrafish-in-terms-of-gene-expression-and-dna-damage
#10
Halis Boran, Savaş Şaffak
With the use of nanoparticles (NPs) in many industrial activities and consumer products, it is important to evaluate the effects of their release into the environment. Metal NPs (e.g., Ni-NPs or Cu-NPs) can release metal ions that are toxic to aquatic organisms; however, whether the toxicity is from metal ions rather than unique "nano-scale" effects of the NPs is unresolved. This research investigated Ni-NP toxicity in zebrafish Danio rerio larvae to clarify whether toxic effects are attributable to release of Ni ions...
October 22, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29035311/modeling-of-interactions-between-the-zebrafish-hatching-enzyme-zhe1-and-a-series-of-metal-oxide-nanoparticles-nano-qsar-and-causal-analysis-of-inactivation-mechanisms
#11
Natalia Sizochenko, Danuta Leszczynska, Jerzy Leszczynski
The quantitative relationships between the activity of zebrafish ZHE1 enzyme and a series of experimental and physicochemical features of 24 metal oxide nanoparticles were revealed. Vital characteristics of the nanoparticles' structure were reflected using both experimental and theoretical descriptors. The developed quantitative structure-activity relationship model for nanoparticles (nano-QSAR) was capable of predicting the enzyme inactivation based on four descriptors: the hydrodynamic radius, mass density, the Wigner-Seitz radius, and the covalent index...
October 16, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29029321/rapid-novel-facile-biosynthesized-silver-nanoparticles-from-bacterial-release-induce-biogenicity-and-concentration-dependent-in-vivo-cytotoxicity-with-embryonic-zebrafish-a-mechanistic-insight
#12
Suresh K Verma, Ealisha Jha, Pritam Kumar Panda, Anurag Mishra, Arun Thirumurugan, Biswadeep Das, S K S Parashar, Mrutyunjay Suar
In this study, rapid one step facile synthesis of silver nanoparticles (AgNP) was done using culture supernatant of two Gram positive (B.thuringiensis, S.aureus) and Gram negative (E.coli, S.typhimurium) bacterial strains and were termed as "BTAgNP", "SAAgNP", "ECAgNP" and "STAgNP" respectively. Synthesized AgNPs were well characterized with the help of different standard techniques like FESEM, DLS, UV-Vis spectroscopy and FTIR. Mechanism of AgNPs synthesis was elucidated using in silico approach. In vivo cytotoxicity of synthesized AgNPs was assessed in embryonic Zebrafish model with the help of uptake, oxidative stress and apoptosis induction experimental assays and the mechanism was investigated through in silico approach at the molecular level...
September 28, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28993268/nanotoxicological-and-teratogenic-effects-a-linkage-between-dendrimer-surface-charge-and-zebrafish-developmental-stages
#13
Maria Natalia Calienni, Daniela Agustina Feas, Daniela Edith Igartúa, Nadia Silvia Chiaramoni, Silvia Del Valle Alonso, Maria Jimena Prieto
This article reports novel results about nanotoxicological and teratogenic effects of the PAMAM dendrimers DG4 and DG4.5 in zebrafish (Danio rerio). Zebrafish embryos and larvae were used as a rapid, high-throughput, cost-effective whole-animal model. The objective was to provide a more comprehensive and predictive developmental toxicity screening of DG4 and DG4.5 and test the influence of their surface charge. Nanotoxicological and teratogenic effects were assessed at developmental, morphological, cardiac, neurological and hepatic level...
December 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28987218/cover-story-zebrafish-as-a-screening-tool-for-the-systemic-circulation-of-nanoparticles
#14
EDITORIAL
Kinam Park
No abstract text is available yet for this article.
October 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28957717/copper-impairs-zebrafish-swimbladder-development-by-down-regulating-wnt-signaling
#15
JiangPing Xu, RuiTao Zhang, Ting Zhang, Guang Zhao, Yan Huang, HuanLing Wang, Jing-Xia Liu
Copper nanoparticles (CuNPs) are used widely in different fields due to their attractive and effective abilities in inhibiting bacteria and fungi, but little information is available about their biological effects and potential molecular mechanisms on fish development. Here, CuNPs and copper (II) ions (Cu(2+)) were revealed to inhibit the specification and formation of three layers of zebrafish embryonic posterior swimbladder and impair its inflation in a stage-specific manner. CuNPs and Cu(2+) were also revealed to down-regulate Wnt signaling in embryos...
September 21, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28943148/in%C3%A2-vivo-safety-evaluation-of-antibacterial-silver-chloride-nanoparticles-from-streptomyces-exfoliatus-icn25-in-zebrafish-embryos
#16
Appadurai Muthamil Iniyan, Rajaretinam Rajesh Kannan, Francis-Joseph Rosemary Sharmila Joseph, Thankaraj Rajam Jabila Mary, Mani Rajasekar, Puthenpurayil Chellappan Sumy, Arul Maximus Rabel, Dasnamoorthy Ramachandran, Samuel Gnana Prakash Vincent
Silver chloride nanoparticles were synthesized from the cell-free culture supernatant of Streptomyces strain using green synthesis approach with good yield. The nanoparticles were characterized by UV-Vis, IR, SEM, AFM and XRD techniques. These nanoparticles exhibited broad spectrum of antibacterial activity towards Methicillin-resistant Staphylococcus aureus, Methicillin sensitive S. aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumonia at ≤ 2 μg/ml minimal inhibitory concentrations...
September 21, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28912673/improving-the-delivery-of-sod1-antisense-oligonucleotides-to-motor-neurons-using-calcium-phosphate-lipid-nanoparticles
#17
Liyu Chen, Clare Watson, Marco Morsch, Nicholas J Cole, Roger S Chung, Darren N Saunders, Justin J Yerbury, Kara L Vine
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease affecting the upper and lower motor neurons in the motor cortex and spinal cord. Abnormal accumulation of mutant superoxide dismutase I (SOD1) in motor neurons is a pathological hallmark of some forms of the disease. We have shown that the orderly progression of the disease may be explained by misfolded SOD1 cell-to-cell propagation, which is reliant upon its active endogenous synthesis. Reducing the levels of SOD1 is therefore a promising therapeutic approach...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28884420/relation-between-biophysical-properties-of-nanostructures-and-their-toxicity-on-zebrafish
#18
REVIEW
C S Martinez, D E Igartúa, M N Calienni, D A Feas, M Siri, J Montanari, N S Chiaramoni, S Del V Alonso, M J Prieto
In recent years, the use of commercial nanoparticles in different industry and health fields has increased exponentially. However, the uncontrolled application of nanoparticles might present a potential risk to the environment and health. Toxicity of these nanoparticles is usually evaluated by a fast screening assay in zebrafish (Danio rerio). The use of this vertebrate animal model has grown due to its small size, great adaptability, high fertilization rate and fast external development of transparent embryos...
October 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28876356/a-versatile-upconversion-surface-evaluation-platform-for-bio-nano-surface-selection-for-the-nervous-system
#19
Libing Fu, Marco Morsch, Bingyang Shi, Guoying Wang, Albert Lee, Rowan Radford, Yiqing Lu, Dayong Jin, Roger Chung
There is considerable interest in developing diagnostic nanotools for early detection and delivery of various therapeutic agents for treatment of neurodegenerative diseases. However, a key challenge remains in the selection of suitable surfaces to overcome the nano-bio interface issue, namely that many nanoparticle surfaces demonstrate instability when administered into biological environments and show substantial cytotoxicity to the central nervous system. In this study, we fabricated an evaluation platform for bio-nano surface selection based on the combination of upconversion nanoparticles (UCNPs), cultured neural cells and zebra fish, and systemically demonstrated how it can evaluate the suitability of nanoparticle surfaces for applications in the central nervous system...
September 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28866281/integrated-assessment-of-toxic-effects-of-maghemite-%C3%AE-fe2o3-nanoparticles-in-zebrafish
#20
Rolando A R Villacis, José S Filho, Benjamin Piña, Ricardo B Azevedo, Aline Pic-Taylor, Juliana F Mazzeu, Cesar K Grisolia
The increasing use of nanotechnology in the last decade has raised concerns about the impact of nanoparticles in the environment. In particular, the potential harmful effects of iron oxide nanoparticles (IONPs) in aquatic organisms have been poorly addressed. We analyze here the toxic effects induced by IONPs in zebrafish using a combination of classical (genotoxicity, oxidative stress) and molecular (transcriptomic) methodologies. Adult animals were exposed for 96h to five sub-lethal IONP concentrations, ranging from 4...
August 8, 2017: Aquatic Toxicology
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