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Zebrafish nanoparticle

Srinath Patibandla, Yinan Zhang, Ali Mohammad Tohari, Peng Gu, James Reilly, Yu Chen, Xinhua Shu
The use of nanoparticles - particles that range in size from 1 to 100 nm - has become increasingly prevalent in recent years, bringing with it a variety of potential toxic effects. Zebrafish embryos were exposed during the 3 day postfertilization period to gold nanospheres (GNSs), gold nanorods (GNRs), GNRs coated with polystyrene sulphate (PSS-GNRs) and GNRs coated with both PSS and polyallamine hydrochloride (PAH-PSS-GNRs). All nanorods were stabilized with cetyltrimethylammonium bromide. GNSs were the least toxic of the nanoparticles studied, with exposure resulting in no significant changes in mortality, hatching or heart rate...
April 15, 2018: Journal of Applied Toxicology: JAT
David Hanigan, Lisa Truong, Jared Schoepf, Takayuki Nosaka, Anjali Mulchandani, Robert L Tanguay, Paul Westerhoff
Both nanoparticulate (nZnO and nTiO2 ) and organic chemical ultraviolet (UV) filters are active ingredients in sunscreen and protect against skin cancer, but limited research exists on the environmental effects of sunscreen release into aquatic systems. To examine the trade-offs of incorporating nanoparticles (NPs) into sunscreens over the past two decades, we targeted endpoints sensitive to the potential risks of different UV filters: solar reactive oxygen production in water and disruption of zebrafish embryo development...
March 27, 2018: Water Research
Meng Li, Qiong Wu, Qiangwei Wang, Dandan Xiang, Guonian Zhu
In aquatic environment, the presence of nanoparticles (NPs) has been reported to modify the bioavailability and toxicity of the organic toxicants. Nevertheless, the combined toxicity of NPs and the pesticides that were used world-widely still remains unclear. Cypermethrin (CYP), a synthetic pyrethroid insecticide, is commonly used for controlling agricultural and indoor pests. Therefore, the effects of titanium dioxide NPs (nTiO2 ) on CYP bioconcentration and its effects on the neuronal development in zebrafish were investigated in our study...
March 31, 2018: Aquatic Toxicology
Sven H C Askes, Nelli Bossert, Jeroen Bussmann, Victorio Saez Talens, Michael S Meijer, Roxanne E Kieltyka, Alexander Kros, Sylvestre Bonnet, Doris Heinrich
The long-term fate of biomedical nanoparticles after endocytosis is often only sparsely addressed in vitro and in vivo, while this is a crucial parameter to conclude on their utility. In this study, dual-fluorescent polyisobutylene-polyethylene glycol (PiB-PEG) polymersomes were studied for several days in vitro and in vivo. In order to optically track the vesicles' integrity, one fluorescent probe was located in the membrane and the other in the aqueous interior compartment. These non-toxic nanovesicles were quickly endocytosed in living A549 lung carcinoma cells but unusually slowly transported to perinuclear lysosomal compartments, where they remained intact and luminescent for at least 90 h without being exocytosed...
March 22, 2018: Biomaterials
Shuang Zhou, Yanhui Sun, Xiao Kuang, Shanshan Hou, Zhenjie Wang, Zhe Qian, Hongzhuo Liu
One of the major challenges in the treatment of hearing loss is the low efficacy of therapeutic candidates. To achieve the optimum drug efficacy, we designed a novel peptide (D-Arg-Dmt-Arg-Phe-NH2 )-mediated mitochondrial targeted delivery nanosystem for a promising candidate, geranylgeranylacetone (GGA). The zebrafish lateral line system, a robust model for mammalian hair cells, was used to identify the efficacy against gentamicin, a well-known ototoxic agent. The nanosystem facilitated lysosomal escape and mitochondrial accumulation, and thus conferred superior protective efficacy against a wide range of gentamicin compared with unmodified NPs and free drugs...
March 29, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Minling Gao, Yujuan Yang, Mengting Lv, Wenhua Song, Zhengguo Song
This study investigated the acute and sub-acute toxicity responses in zebrafish following their exposure to hydroxyapatite-loaded cadmium nanoparticles (nHAP-Cd). The results indicate that cadmium chloride (Cd2+ ), 20 nm nHAP-Cd (nHAP20 -Cd), and 40 nm nHAP-Cd (nHAP40 -Cd) caused toxicity in zebrafish; the toxicity levels were in the following order: Cd2+  > nHAP20 -Cd > nHAP40 -Cd. Furthermore, nHAP-Cd showed level II grade of acute toxicity in zebrafish; the gradation was done on the guidelines of the Organization for Economic Co-operation and Development 203...
March 21, 2018: Chemosphere
Jing Tu, Jeroen Bussmann, Guangsheng Du, Yue Gao, Joke A Bouwstra, Alexander Kros
Hemoglobin (Hb)-loaded mesoporous silica nanoparticles (MSNs) coated with a lipid bilayer (LB-MSNs) were investigated as an erythrocyte mimic. MSNs with a large average pore size (10 nm) act as a rigid core and provide a protective environment for Hb encapsulated inside the pores. The colloidal stability of Hb-loaded MSNs was enhanced upon the application of a lipid bilayer, through fusion of PEGylated liposomes onto the exterior surface of Hb-loaded MSNs. The morphology and mesostructure of the MSNs were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and surface area analysis...
March 19, 2018: International Journal of Pharmaceutics
Khan Behlol Ayaz Ahmed, Thiagarajan Raman, Anbazhagan Veerappan
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
March 20, 2018: Scientific Reports
Zhiqi Xie, Wangwei Guo, Ningning Guo, Mingyi Huangfu, Huina Liu, Mengting Lin, WenHong Xu, Jiejian Chen, TianTian Wang, Qichun Wei, Min Han, Jianqing Gao
Although existing nanomedicines have focused on the tumor microenvironment with the goal of improving the effectiveness of conventional chemotherapy, the penetration of a tumor's core still represents a formidable barrier for existing drug delivery systems. Therefore, a novel multifunctional hypoxia-induced size-shrinkable nanoparticle has been designed to increase the penetration of drugs, nucleic acids, or probes into tumors. This cooperative strategy relies on three aspects: (i) the responsiveness of nanoparticles to hypoxia, which shrink when triggered by low oxygen concentrations; (ii) the core of a nanoparticle involves an internal cavity and strong positive charges on the surface to deliver both doxorubicin and siRNA; and (iii) a reactive oxygen species (ROS) probe is incorporated in the nanoparticle to monitor its preliminary therapeutic response in real time, which is expected to realize the enhanced efficacy together with the ability to self-monitor the anticancer activity...
March 12, 2018: Acta Biomaterialia
Gyo Eun Gu, Chul Soon Park, Hyun-Ju Cho, Tai Hwan Ha, Joonwon Bae, Oh Seok Kwon, Jeong-Soo Lee, Chang-Soo Lee
Fluorescent polydopamine nanoparticles (FPNPs) are prepared via the ethylenediamine (EDA)-induced degradation of as-prepared non-fluorescent polydopamine (PDA) and used for targeted bioimaging. The reductive treatment of PDA in the presence of EDA yields fluorescent precipitates, inspiring us to seek various biological approaches to preparing FPNPs with excellent optical and biocompatible properties. Moreover, we firstly found that FPNPs selectively label neuromast hair cells in the lateral line of zebrafish, their applications as a reliable fluorescent indicator to investigate the neuromast hair cells, to in turn determine the viability of hair cells, was demonstrated...
March 13, 2018: Scientific Reports
Narahari Rishitha, Arunachalam Muthuraman
BACKGROUND: Quercetin is a major flavonoid in various plants. It possesses the multiple pharmacological actions like vascular integrity and regulatory action of the blood-brain barrier. AIMS: The present study is focused on evaluating the role of solid lipid nanoparticle of quercetin in pentylenetetrazole (PTZ) induced cognitive impairment of Danio rerio species. MAIN METHODS: The memory impairment of zebrafish was induced by exposing of PTZ in 7...
March 6, 2018: Life Sciences
Chamilani Nikapitiya, S H S Dananjaya, B C J De Silva, Gang-Joon Heo, Chulhong Oh, Mahanama De Zoysa, Jehee Lee
Chitosan nanoparticles (CNPs) were synthesized by ionic gelation method and its immunomodulatory properties were investigated in zebrafish larvae. Average particle size and zeta potential were 181.2 nm and +37.2 mv, respectively. Initially, toxicity profile was tested in zebrafish embryo at 96 h post fertilization (hpf) stage using medium molecular weight chitosan (MMW-C) and CNPs. At 5 μg/mL, the hatching rate was almost similar in both treatments, however, the survival rate was lower in MMW-C compared to CNPs exposure, suggesting that toxicity effect of CNPs in hatched larvae was minimal at 5 μg/mL compared to MMW-C...
March 3, 2018: Fish & Shellfish Immunology
Bohan Yin, Kin Hei Kelvin Li, Lok Wai Cola Ho, Cecilia Ka Wing Chan, Chung Hang Jonathan Choi
A longstanding and widely accepted bottleneck in the targeted delivery of intravenously injected nanoparticles lies in their clearance by macrophages in the liver and spleen. In this Perspective, we call for deeper understanding of the critical role of endothelial cells in the sequestration of nanoparticles in vivo. In this issue of ACS Nano, Campbell et al. used a combination of real-time imaging and genome-editing methods to demonstrate that stabilin-2 is an important receptor for removing anionic liposomes from blood circulation in a zebrafish model...
February 27, 2018: ACS Nano
Jingwen Huang, Xiangyu Zhang, Zhihao Wu, Yufeng Wu, Xiaojie Wu, Yunguang Wang, Hao Jiang, Jing Ma, Zelai He
(Arginine-Glycine-Aspartic)-methoxy polyethylene glycol-(1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N) (abbreviation: RGD-PEG2000-DSPE or RGD-PD) was successfully synthesized and verified by 1H-NMR and MALDI-TOF MS. Polyethylene glycol-poly-L-lysine/RGD-PD/phospholipid/calcium phosphate nanoparticles (PEG-PLL/RGD-PD/PL/CaP NPs or MNPs) were prepared using a novel, simple method conducted at room temperature. Transmission electron microscopy (TEM) analysis showed that the MNPs were spheres of uniform size, with a diameter of ∼30 nm, and smooth surface...
January 1, 2018: Journal of Biomedical Nanotechnology
Khan Behlol Ayaz Ahmed, Thiagarajan Raman, Anbazhgan Veerappan
Bacterial resistance is a major clinical problem, which is compounded by both a lack of new antibiotics and emergence of multi- and extremely-drug resistant microbes. In this context, non-toxic nanoparticles could play an important role in conferring protection against bacterial infections and in this study we have made an attempt to show the usefulness of jacalin capped platinum nanoparticles in protecting zebrafish against multiple infections with Aeromonas hydrophila. Our results also indicate that use of nanoparticles promotes adaptive immune response against the pathogen, so much so that zebrafish is able to survive repetitive infection even after twenty one days of being treated with jacalin-capped platinum nanoparticles...
February 2, 2018: Scientific Reports
Clay Patton, Gist H Farr, Ding An, Paolo G V Martini, Lisa Maves
Lipid nanoparticles (LNPs) are an attractive platform for the delivery of therapeutic RNA molecules because LNPs are versatile, have been validated in clinical trials, and are well tolerated. Here, we test whether LNPs can be used to deliver a reporter green fluorescent protein (gfp) mRNA to different tissues in zebrafish embryos. We show that LNP-packaged gfp mRNA can be delivered, through injection, and taken up by cells in multiple tissues in zebrafish embryos without any apparent detrimental effects on embryonic health or survival...
January 25, 2018: Zebrafish
Wubshet Mekonnen Girma, Shin-Hwa Tzing, Po-Jen Tseng, Chih-Ching Huang, Yong-Chien Ling, Jia-Yaw Chang
In this study, for the first time, CuFeS2 nanocrystals were successfully prepared through a facile noninjection-based synthetic strategy, by reacting Cu and Fe precursors with dodecanethiol in a 1-octadecene solvent. This one-pot noninjection strategy features easy handling, large-scale production, and high synthetic reproducibility. Following hyaluronic acid (HA) encapsulation, CuFeS2 nanocrystals coated with HA (CuFeS2 @HA) not only readily dispersed in water and showed improved biocompatibility but also possessed a tumor-specific targeting ability of cancer cells bearing the cluster determinant 44 (CD44) receptors...
February 7, 2018: ACS Applied Materials & Interfaces
Reena C Jhamtani, Saurabh Shukla, P Sivaperumal, M S Dahiya, Rakhi Agarwal
Aldrin (ALD), a persistent-organic-pollutant (POP), an organochlorine-cyclodiene-pesticide is highly toxic in nature. Titanium dioxide nanoparticles (TNP) are widely used for various industrial applications. Despite the remarkable research on pesticide toxicity, the work with impact of nanoparticles on POP has been dealt with marginally. Chemicals co-exist in the environment and exhibit interactive effects. An investigation was carried out to evaluate the individual and combined effects of ALD (6 ppm) and TNP (60 ppm) exposure at sub-lethal concentration for 24 h in zebrafish...
March 2018: Environmental Toxicology and Pharmacology
Frederick Campbell, Frank L Bos, Sandro Sieber, Gabriela Arias-Alpizar, Bjørn E Koch, Jörg Huwyler, Alexander Kros, Jeroen Bussmann
Up to 99% of systemically administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells), although significant nanoparticle interactions with other hepatic cells have also been observed. To achieve effective cell-specific targeting of drugs through nanoparticle encapsulation, improved mechanistic understanding of nanoparticle-liver interactions is required. Here, we show the caudal vein of the embryonic zebrafish ( Danio rerio) can be used as a model for assessing nanoparticle interactions with mammalian liver sinusoidal (or scavenger) endothelial cells (SECs) and macrophages...
March 27, 2018: ACS Nano
Xiaojiao Li, Lele Song, Xingjie Hu, Chang Liu, Jiye Shi, Hui Wang, Lixing Zhan, Haiyun Song
Titanium dioxide nanoparticles (TiO2 NPs) are among the most widely manufactured nanomaterials with broad applications in food industry, cosmetics, and medicine. Although the toxicity of TiO2 NPs at high doses has been extensively explored, the potential health risks of TiO2 NPs exposure at nontoxic concentrations remain poorly understood. Epithelial-mesenchymal transition (EMT) plays pivotal roles in a diversity of physiological and pathological processes, including tissue regeneration and cancer metastasis...
January 31, 2018: ACS Applied Materials & Interfaces
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