keyword
MENU ▼
Read by QxMD icon Read
search

Zebrafish nanoparticle

keyword
https://www.readbyqxmd.com/read/28720487/pdms-b-pmoxa-polymersomes-for-hepatocyte-targeting-and-assessment-of-toxicity
#1
Klara Kiene, Susanne H Schenk, Fabiola Porta, Alexandra Ernst, Dominik Witzigmann, Philip Grossen, Jörg Huwyler
Nanoparticles, such as polymersomes, can be directed to the hepatic asialoglycoprotein receptor to achieve targeted drug delivery. In this study, we prepared asialofetuin conjugated polymersomes based on the amphiphilic di-block copolymer poly(dimethylsiloxane)-b-poly(2-methyloxazoline) (PDMS-b-PMOXA). They had an average diameter of 150nm and formed monodisperse vesicles. Drug encapsulation and sustained release was monitored using the hydrophilic model compound carboxyfluorescein. Asialoglycoprotein receptor specific uptake by HepG2 cells in vitro was energy dependent and could be competitively inhibited by the free targeting ligand...
July 15, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28711009/comprehensive-gene-and-microrna-expression-profiling-on-cardiovascular-system-in-zebrafish-co-exposured-of-sinps-and-mehg
#2
Hejing Hu, Yanfeng Shi, Yannan Zhang, Jing Wu, Collins Otieno Asweto, Lin Feng, Xiaozhe Yang, Junchao Duan, Zhiwei Sun
Air pollution has been shown to increase cardiovascular diseases. However, little attention has been paid to the combined effects of PM and air pollutants on the cardiovascular system. To explore this, a high-throughput sequencing technology was used to determine combined effects of silica nanoparticles (SiNPs) and MeHg in zebrafish. Our study demonstrated that SiNPs and MeHg co-exposure could cause significant changes in mRNA and miRNA expression patterns in zebrafish. The differentially expressed (DE) genes in profiles 17 and 26 of STC analysis suggest that SiNPs and MeHg co-exposure had more proinflammatory and cardiovascular toxicity in zebrafish than single exposure...
July 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28709896/comparative-study-on-antifungal-activities-of-chitosan-nanoparticles-and-chitosan-silver-nano-composites-against-fusarium-oxysporum-species-complex
#3
S H S Dananjaya, W K C U Erandani, Cheol-Hee Kim, Chamilani Nikapitiya, Jehee Lee, Mahanama De Zoysa
Though the metal nanoparticles (NPs) have been shown favorable results against fungal diseases, erratic environmental toxicity of NPs have raised serious concerns against their applications. Hence, it is vital to modify antifungal compounds into safe substitutes over synthetic chemicals. In this study, antifungal effects of chitosan nanoparticles (CNPs) and chitosan silver nanocomposites (CAgNCs) were compared against Fusarium oxysporum species complex. CNPs and CAgNCs were synthesized, characterized and compared based on the transmission electron microscope, X-ray diffraction, UV-vis absorbance spectra, particle size distribution, zeta potential and thermal stability analysis...
July 11, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28704675/effect-of-single-wall-carbon-nanotubes-on-bioconcentration-and-toxicity-of-perfluorooctane-sulfonate-in-zebrafish-danio-rerio
#4
Yaxuan Li, Bin Men, Yi He, Haiming Xu, Meiqi Liu, Dongsheng Wang
The wide application of nanoparticles will lead its release into the aquatic environment, which may alter the bioavailability and toxicity of other contaminants to aquatic organisms. This work aimed to study the effects of perfluorooctane sulfonate (PFOS), single-wall carbon nanotubes (SWCNT), and their mixture on PFOS accumulation, antioxidant defenses and acetylcholinesterase (AChE) activity in zebrafish. The fish was dissected after being exposed (24, 48, 72 and 96h) separately to PFOS, SWCNT and PFOS+SWCNT co-exposure...
July 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28702993/gold-nanorod-induced-warming-of-embryos-from-the-cryogenic-state-enhances-viability
#5
Kanav Khosla, Yiru Wang, Mary Hagedorn, Zhenpeng Qin, John Bischof
Zebrafish embryos can attain a stable cryogenic state by microinjection of cryoprotectants followed by rapid cooling, but the massive size of the embryo has consistently led to failure during the convective warming process. Here we address this zebrafish cryopreservation problem by using gold nanorods (GNRs) to assist in the warming process. Specifically, we microinjected the cryoprotectant propylene glycol into zebrafish embryos along with GNRs, and the samples were cooled at a rate of 90 000 °C/min in liquid nitrogen...
July 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28696918/gold-nanorods-induce-early-embryonic-developmental-delay-and-lethality-in-zebrafish-danio-rerio
#6
Bárbara Mesquita, Isabel Lopes, Susana Silva, Maria João Bessa, Maksim Starykevich, Jorge Carneiro, Tiago L P Galvão, Mário G S Ferreira, João Tedim, João Paulo Teixeira, Sónia Fraga
Due to their unique electronic and optical features, gold nanoparticles (AuNP) have received a great deal of attention for application in different fields such as catalysis, electronics, and biomedicine. The large-volume manufacturing predicted for future decades and the inevitable release of these substances into the environment necessitated an assessment of potential adverse human and ecological risks due to exposure to AuNP. Accordingly, this study aimed to examine the acute and developmental toxicity attributed to a commercial suspension of Au nanorods stabilized with cetyltrimethylammonium bromide (CTAB-AuNR) using early embryonic stages of zebrafish (Danio rerio), a well-established model in ecotoxicology...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28686897/exploring-uptake-and-biodistribution-of-polystyrene-nano-particles-in-zebrafish-embryos-at-different-developmental-stages
#7
M van Pomeren, N R Brun, W J G M Peijnenburg, M G Vijver
In ecotoxicology, it is continuously questioned whether (nano)particle exposure results in particle uptake and subsequent biodistribution or if particles adsorb to the epithelial layer only. To contribute to answering this question, we investigated different uptake routes in zebrafish embryos and how they affect particle uptake into organs and within whole organisms. This is addressed by exposing three different life stages of the zebrafish embryo in order to cover the following exposure routes: via chorion and dermal exposure; dermal exposure; oral and dermal exposure...
June 19, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28652584/mapping-the-glyco-gold-nanoparticles-of-different-shapes-toxicity-biodistribution-and-sequestration-in-adult-zebrafish
#8
Sivakoti Sangabathuni, Raghavendra Vasudeva Murthy, Preeti Madhukar Chaudhary, Balamurugan Subramani, Suraj Toraskar, Raghavendra Kikkeri
Glyconanotechnology offers a broad range of applications across basic and translation research. Despite the tremendous progress in glyco-nanomaterials, there is still a huge gap between the basic research and therapeutic applications of these molecules. It has been reported that complexity and the synthetic challenges in glycans synthesis, the cost of the high order in vivo models and large amount of sample consumptions limited the effort to translate the glyco-nanomaterials into clinical applications. In this regards, several promising simple animal models for preliminary, quick analysis of the nanomaterials activities has been proposed...
June 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28650045/targeted-delivery-of-geranylgeranylacetone-to-mitochondria-by-triphenylphosphonium-modified-nanoparticles-a-promising-strategy-to-prevent-aminoglycoside-induced-hearing-loss
#9
Zhenjie Wang, Xiao Kuang, Jia Shi, Weiling Guo, Hongzhuo Liu
Prevention of hair cell death is an important target for the prevention of hearing loss. Here, we report the engineering of biodegradable poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) decorated with triphenylphosphonium (TPP) cations as a robust mitochondrial delivery platform, with the aim of preserving mitochondrial integrity and shutting off the initiation of cell death. Geranylgeranylacetone (GGA), a 70 kDa heat shock protein (HSP70) inducer, was used as a therapeutic molecule to attenuate gentamicin (Gen) induced hearing loss...
June 26, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28627489/treatment-of-francisella-infections-via-plga-and-lipid-based-nanoparticle-delivery-of-antibiotics-in-a-zebrafish-model
#10
Lilia S Ulanova, Marina Pinheiro, Carina Vibe, Claudia Nunes, Dorna Misaghian, Steven Wilson, Kaizheng Zhu, Federico Fenaroli, Hanne C Winther-Larsen, Salette Reis, Gareth Griffiths
We tested the efficiency of 2 different antibiotics, rifampicin and oxolinic acid, against an established infection caused by fish pathogen Francisella noatunensis ssp. orientalis (F.n.o.) in zebrafish. The drugs were tested in the free form as well as encapsulated into biodegradable nanoparticles, either polylactic-co-glycolic acid (PLGA) nanoparticles or nanostructured lipid carriers. The most promising therapies were PLGA-rifampicin nanoparticles and free oxolinic acid; the PLGA nanoparticles significantly delayed embryo mortality while free oxolinic acid prevented it...
June 19, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28623802/developmental-toxicity-of-glycine-coated-silica-nanoparticles-in-embryonic-zebrafish
#11
Eduard Dumitrescu, Dinusha P Karunaratne, Morgan K Prochaska, Xiaobo Liu, Kenneth N Wallace, Silvana Andreescu
Nanoparticle (NP) surface coatings are known to influence the toxicity of engineered nanomaterials. This work examines the effect of glycine functionalization on silica NPs and investigates changes in viability and developmental defects in the organs of zebrafish embryos upon exposure. Silica NPs and glycine-functionalized silica NPs are synthesized and characterized. Exposure of zebrafish embryos to glycine-silica NPs affects the mortality percentage in a similar manner to soluble glycine. Developmental defects are observed in embryos exposed to soluble glycine, glycine-silica NPs, or silica NPs in comparison with the unexposed embryos...
June 14, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28570891/silica-nanoparticles-inhibit-macrophage-activity-and-angiogenesis-via-vegfr2-mediated-mapk-signaling-pathway-in-zebrafish-embryos
#12
Junchao Duan, Hejing Hu, Lin Feng, Xiaozhe Yang, Zhiwei Sun
The safety evaluation of silica nanoparticles (SiNPs) are getting great attention due to its widely-used in food sciences, chemical industry and biomedicine. However, the adverse effect and underlying mechanisms of SiNPs on cardiovascular system, especially on angiogenesis is still unclear. This study was aimed to illuminate the possible mechanisms of SiNPs on angiogenesis in zebrafish transgenic lines, Tg(fli-1:EGFP) and Albino. SiNPs caused the cardiovascular malformations in a dose-dependent manner via intravenous microinjection...
May 24, 2017: Chemosphere
https://www.readbyqxmd.com/read/28521150/the-effects-of-copper-oxide-nanoparticles-on-dorsoventral-patterning-convergent-extension-and-neural-and-cardiac-development-of-zebrafish
#13
Jia Xu, Qiuping Zhang, Xu Li, Sihui Zhan, Lifeng Wang, Dongyan Chen
Currently, nanoparticles are widely used in biomedicine and industry. CuO nanoparticles (CuO-NPs) are versatile materials in our daily life and their toxicity has drawn extensive attention. In this study, we concentrate on the effect of CuO-NPs on early zebrafish development. The results reveal that CuO-NPs can induce abnormal phenotypes of a smaller head and eyes and delayed epiboly. The gene expression pattern shows that CuO-NPs spatially narrow the expression of dorsal genes chordin and goosecoid and alter the expression of dlx3, ntl and hgg which are related to the cell migration of gastrulation...
May 4, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28503921/fluorescent-nanoparticles-with-tissue-dependent-affinity-for-live-zebrafish-imaging
#14
Deepak Kumar Khajuria, Vijay Bhooshan Kumar, David Karasik, Aharon Gedanken
Carbon quantum dots (CDs) are widely investigated because of their low toxicity, outstanding water solubility, and high biocompatibility. Specifically, fluorescent CDs have attracted ever-increasing interest. However, so far, only a few studies have focused on assessing the fluorescence of nitrogen-doped CDs (N@CDs) during in vivo exposure. Here, we describe a strategy for low-cost, one-pot synthesis of N@CDs. The low toxicity and suitability of the N@CDs for fluorescence imaging are validated using zebrafish (ZF) as a model...
June 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28486138/the-effects-of-titanium-dioxide-nanoparticles-on-ultrastructure-of-zebrafish-testis-danio-rerio
#15
Tuğba Kotil, Cansu Akbulut, Nazan Deniz Yön
INTRODUCTION: Nanotechnology investigates materials at nanoscale level (0.1-100nm in diameter). There are many commercially nanoproducts such as silver, silicon, titanium, zinc, and gold. They are used in a variety of applications and released to the environment. Titanium dioxide (TiO2) is one of the most commonly used nanoparticles (NP). In this study, the ultrastructural effects of TiO2-NP on zebrafish testis tissue were evaluated. MATERIAL AND METHOD: Zebrafish were divided into four groups (N=60) as one control and 3 experimental groups (1mg/L, 2mg/L and 4mg/L TiO2)...
September 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28451175/controllable-no-release-from-cu1-6s-nanoparticle-decomposition-of-s-nitrosoglutathiones-following-photothermal-disintegration-of-polymersomes-to-elicit-cerebral-vasodilatory-activity
#16
Po-Tsung Kao, I-Ju Lee, Ian Liau, Chen-Sheng Yeh
Since the discovery of nitric oxide (NO) as a vasodilator, numerous NO therapies have been attempted to remedy disorders related to pathological vasoconstriction such as coronary artery disease. Despite the advances, clinical applications of NO therapies remain limited mainly because of the low stability of molecular NO donors (and NO molecules), and concerns about the increased oxidative stress and reduced arterial pressure associated with the systemic administration of NO. Here we design a photo-responsive polymersome with nitrosothiols and Cu1...
January 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28441729/the-influence-of-hydroxyapatite-nanoparticle-morphology-on-embryonic-development-in-a-zebrafish-exposure-model
#17
Shiuli Pujari-Palmer, Xi Lu, Marjam Karlsson Ott
Nanomaterials are used in many different industries such as cosmetics, food, clothing, and electronics. There is increasing concern that exposure to nanoparticles (NPs) during pregnancy can adversely affect fetal development. It is well known that the size, charge, and chemistry of a nanoparticle can modulate embryological development. The role that particle morphology plays on early development, however, is still widely unknown. The present study aims to investigate the effect of hydroxyapatite nanoparticle (HANP) morphology on embryological development in a zebrafish exposure model...
April 22, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28436959/peptide-mhc-based-nanomedicines-for-autoimmunity-function-as-t-cell-receptor-microclustering-devices
#18
Santiswarup Singha, Kun Shao, Yang Yang, Xavier Clemente-Casares, Patricia Solé, Antonio Clemente, Jesús Blanco, Qin Dai, Fayi Song, Shang Wan Liu, Jun Yamanouchi, Channakeshava Sokke Umeshappa, Roopa Hebbandi Nanjundappa, Pascal Detampel, Matthias Amrein, César Fandos, Robert Tanguay, Susan Newbigging, Pau Serra, Anmar Khadra, Warren C W Chan, Pere Santamaria
We have shown that nanoparticles (NPs) can be used as ligand-multimerization platforms to activate specific cellular receptors in vivo. Nanoparticles coated with autoimmune disease-relevant peptide-major histocompatibility complexes (pMHC) blunted autoimmune responses by triggering the differentiation and expansion of antigen-specific regulatory T cells in vivo. Here, we define the engineering principles impacting biological activity, detail a synthesis process yielding safe and stable compounds, and visualize how these nanomedicines interact with cognate T cells...
July 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28415449/complementary-approaches-for-the-evaluation-of-biocompatibility-of-90-y-labeled-superparamagnetic-citric-acid-fe-er-3o4-coated-nanoparticles
#19
Bratislav Antic, Marko Boskovic, Jasmina Nikodinovic-Runic, Yue Ming, Hongguo Zhang, Emil S Bozin, Drina Janković, Vojislav Spasojevic, Sanja Vranjes-Djuric
Magnetic nanoparticles (MNPs) are of immense interest for diagnostic and therapeutic applications in medicine. Design and development of new iron oxide-based MNPs for such applications is of rather limited breadth without reliable and sensitive methods to determine their levels in body tissues. Commonly used methods, such as ICP, are quite problematic, due to the inability to decipher the origin of the detected iron, i.e. whether it originates from the MNPs or endogenous from tissues and bodily fluids. One of the approaches to overcome this problem and to increase reliability of tracing MNPs is to partially substitute iron ions in the MNPs with Er...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28411182/pegylation-rate-influences-peptide-based-nanoparticles-mediated-sirna-delivery-in-vitro-and-in-vivo
#20
Gudrun Aldrian, Anaïs Vaissière, Karidia Konate, Quentin Seisel, Eric Vivès, Frédéric Fernandez, Véronique Viguier, Coralie Genevois, Franck Couillaud, Héléne Démèné, Dina Aggad, Aurélie Covinhes, Stéphanie Barrère-Lemaire, Sébastien Deshayes, Prisca Boisguerin
Small interfering RNAs (siRNAs) present a strong therapeutic potential because of their ability to inhibit the expression of any desired protein. Recently, we developed the retro-inverso amphipathic RICK peptide as novel non-covalent siRNA carrier. This peptide is able to form nanoparticles (NPs) by self-assembling with the siRNA resulting in the fully siRNA protection based on its protease resistant peptide sequence. With regard to an in vivo application, we investigated here the influence of the polyethylene glycol (PEG) grafting to RICK NPs on their in vitro and in vivo siRNA delivery properties...
June 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
keyword
keyword
116537
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"