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https://www.readbyqxmd.com/read/28571996/the-effect-of-the-use-of-a-tnf-alpha-inhibitor-in-hypothermic-machine-perfusion-on-kidney-function-after-transplantation
#1
Piotr Diuwe, Piotr Domagala, Magdalena Durlik, Janusz Trzebicki, Andrzej Chmura, Artur Kwiatkowski
One of the most important problems in transplantation medicine is the ischemia/reperfusion injury of the organs to be transplanted. The aim of the present study was to assess the effect of tumor necrosis factor-alpha (TNF-alpha) inhibitor etanercept on the machine perfusion hypothermia of renal allograft kidney function and organ perfusion. No statistically significant differences were found in the impact of the applied intervention on kidney machine perfusion during which the average flow and vascular resistance were evaluated...
May 29, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28562595/pre-transplant-immune-factors-may-be-associated-with-bk-polyomavirus-reactivation-in-kidney-transplant-recipients
#2
David DeWolfe, Jinal Gandhi, Matthew R Mackenzie, Thomas A Broge, Evelyn Bord, Amaara Babwah, Didier A Mandelbrot, Martha Pavlakis, Francesca Cardarelli, Raphael Viscidi, Anil Chandraker, Chen S Tan
BK polyomavirus (BKPyV) reactivation in kidney transplant recipients can lead to allograft damage and loss. The elements of the adaptive immune system that are permissive of reactivation and responsible for viral control remain incompletely described. We performed a prospective study evaluating BKPyV-specific T-cell response, humoral response and overall T-cell phenotype beginning pre-transplant through one year post-transplant in 28 patients at two centers. We performed an exploratory analysis of risk factors for the development of viremia and viruria as well as compared the immune response to BKPyV in these groups and those who remained BK negative...
2017: PloS One
https://www.readbyqxmd.com/read/28438668/non-neuronal-neuropeptide-y-and-its-receptors-during-acute-rejection-of-rat-pulmonary-allografts
#3
Jessica Schmitz, Anna Zakrzewicz, Sigrid Wilker, Jitka Kuncová, Andreas Hecker, Veronika Grau, Winfried Padberg, Julia P N Holler
This study tested the hypothesis that neuropeptide Y (NPY) and NPY receptors 1 (Y1) and 2 (Y2) participate in lung allograft rejection. Inflammation in grafts may include interaction between blood leukocytes and graft endothelial cells and marked accumulation of intravascular blood leukocytes. Fewer leukocytes accumulate in lung than in kidney allografts. Lung transplantion was performed in the Dark Agouti to Lewis rat strain combination. Intravascular and intraalveolar leukocytes were isolated from the grafts, and we evaluated the mRNA expression of NPY, Y1, and Y2 by real-time RT-PCR as well as the peptide expression of NPY by radioimmunoassay and immunohistochemistry...
April 21, 2017: Transplant Immunology
https://www.readbyqxmd.com/read/28405598/clearance-of-bk-virus-nephropathy-by-combination-antiviral-therapy-with-intravenous-immunoglobulin
#4
Kathy Kable, Carmen D Davies, Philip J O'connell, Jeremy R Chapman, Brian John Nankivell
BACKGROUND: Reactivation of BK polyoma virus causes a destructive virus allograft nephropathy (BKVAN) with graft loss in 46%. Treatment options are limited to reduced immunosuppression and largely ineffective antiviral agents. Some studies suggest benefit from intravenous immunoglobulin (IVIG). METHODS: We evaluated effectiveness of adjuvant IVIG to eliminate virus from blood and tissue, in a retrospective, single-center cohort study, against standard-of-care controls...
April 2017: Transplantation Direct
https://www.readbyqxmd.com/read/27920569/does-calcium-channel-blockade-have-a-role-in-prevention-of-expression-of-sepsis-in-renal-transplant-recipients
#5
REVIEW
John A D'Elia, Ray E Gleason, Anthony P Monaco, Larry A Weinrauch
Many antihypertensive agents have been demonstrated to assist in preservation of kidney function, among them those that modulate calcium channels. Calcium channel blockers may also be of value in protecting hemodialysis patients from complications of sepsis. In diabetic recipients of kidney transplant allografts treated with cyclosporine, calcium channel blockade has been retrospectively linked to improved graft preservation and to fewer episodes of sepsis. This brief review outlines clinical and experimental publications on potential protection from sepsis by addition of calcium channel blockers to standard antibiotic therapy in individuals who may or may not have normal kidney function, or in the presence or absence of immunosuppression...
2016: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/27878046/back-to-back-comparison-of-mini-open-vs-laparoscopic-technique-for-living-kidney-donation
#6
Christie Rampersad, Premal Patel, Joshua Koulack, Thomas McGregor
INTRODUCTION: Laparoscopic living donor nephrectomy is the standard of care at high-volume renal transplant centres, with benefits over the open approach well-documented in the literature. Herein, we present a retrospective analysis of our single-institution donor nephrectomy series comparing the mini-open donor nephrectomy (mini-ODN) to the laparoscopic donor nephrectomy (LDN) with regards to operative, donor, and recipient outcomes. METHODS: From 2007-2011, there were 89 cases of mini-ODN, at which point our centre transitioned to LDN; 94 cases were performed from 2011-2014...
August 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27862962/effect-of-replacing-race-with-apolipoprotein-l1-genotype-in-calculation-of-kidney-donor-risk-index
#7
B A Julian, R S Gaston, W M Brown, A M Reeves-Daniel, A K Israni, D P Schladt, S O Pastan, S Mohan, B I Freedman, J Divers
Renal allografts from deceased African American donors with two apolipoprotein L1 gene (APOL1) renal-risk variants fail sooner than kidneys from donors with fewer variants. The Kidney Donor Risk Index (KDRI) was developed to evaluate organ offers by predicting allograft longevity and includes African American race as a risk factor. Substituting APOL1 genotype for race may refine the KDRI. For 622 deceased African American kidney donors, we applied a 10-fold cross-validation approach to estimate contribution of APOL1 variants to a revised KDRI...
June 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/27753183/tolerability-of-up-to-200%C3%A2-days-of-prophylaxis-with-valganciclovir-oral-solution-and-or-film-coated-tablets-in-pediatric-kidney-transplant-recipients-at-risk-of-cytomegalovirus-disease
#8
MULTICENTER STUDY
G Varela-Fascinetto, C Benchimol, R Reyes-Acevedo, M Genevray, D Bradley, J Ives, H T Silva
This multicenter, open-label study evaluated the tolerability of extended prophylaxis with valganciclovir in pediatric kidney transplant recipients at risk of CMV disease. Fifty-six patients aged 4 months to 16 years received once-daily valganciclovir oral solution and/or tablets, dosed by BSA and renal function, for up to 200 days. The most common AEs on treatment were upper respiratory tract infection (33.9%), urinary tract infection (33.9%), diarrhea (32.1%), leukopenia (25.0%), neutropenia (23.2%), and headache (21...
February 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/27105881/combined-liver-and-kidney-transplantation-in-children-analysis-of-renal-graft-outcome
#9
Randula Ranawaka, Carla Lloyd, Pat J McKiernan, Sally A Hulton, Khalid Sharif, David V Milford
BACKGROUND: Combined liver-kidney transplantation (CLKT) is the accepted treatment for patients with both liver failure and progressive renal insufficiency. Long-term outcome data for CLKT in children is sparse and controversy exists as to whether simultaneous CLKT with organs from the same donor confers immunologic and survival benefit to the kidney allograft. We report the long-term renal graft outcomes of 40 patients who had simultaneous CLKT. METHODS: A retrospective analysis of kidney graft survival (time from transplantation to death, return to dialysis or last follow-up event) in all pediatric patients (age < 18 years old) who underwent CLKT from March 1994 to January 2015...
September 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/26476207/abo-incompatible-renal-transplants-and-decreased-likelihood-for-developing-immune-responses-to-hla-and-kidney-self-antigens
#10
Vijay Subramanian, Muthukumar Gunasekaran, Joseph P Gaut, Donna Phelan, Neeta Vachharajani, Rowena Delos Santos, Jason Wellen, Surendra Shenoy, T Mohanakumar
Immune responses to HLA and tissue-restricted self-antigens (SAgs) have been proposed to play a role in the pathogenesis of renal allograft (KTx) rejection. However, ABO incompatible (ABOi) KTx recipients (KTxR) following depletion of antibodies (Abs) to blood group antigens had fewer rejections. To determine the mechanisms, pre- and post-transplant sera from ABOi (n=18) and ABO-compatible (ABOc) (n=45) KTxR were analyzed for Abs against HLA class I and II by LABScreen single antigen assay. The development of Abs to SAgs was measured by ELISA...
January 2016: Human Immunology
https://www.readbyqxmd.com/read/26465152/a-randomized-2x2-factorial-clinical-trial-of-renal-transplantation-steroid-free-maintenance-immunosuppression-with-calcineurin-inhibitor-withdrawal-after-six-months-associates-with-improved-renal-function-and-reduced-chronic-histopathology
#11
RANDOMIZED CONTROLLED TRIAL
R Brian Stevens, Kirk W Foster, Clifford D Miles, Andre C Kalil, Diana F Florescu, John P Sandoz, Theodore H Rigley, Tamer Malik, Lucile E Wrenshall
INTRODUCTION: The two most significant impediments to renal allograft survival are rejection and the direct nephrotoxicity of the immunosuppressant drugs required to prevent it. Calcineurin inhibitors (CNI), a mainstay of most immunosuppression regimens, are particularly nephrotoxic. Until less toxic antirejection agents become available, the only option is to optimize our use of those at hand. AIM: To determine whether intensive rabbit anti-thymocyte globulin (rATG) induction followed by CNI withdrawal would individually or combined improve graft function and reduce graft chronic histopathology-surrogates for graft and, therefore, patient survival...
2015: PloS One
https://www.readbyqxmd.com/read/26281145/effects-of-two-preemptive-post-transplant-desensitization-regimens-upon-renal-allograft-survival-and-dsa-elaboration
#12
Pamela M Kimball, Felecia A McDougan, Anne King
We used a simple point-based algorithm to identify patients who might benefit from desensitization because of their higher risk of antibody-mediated chronic rejection and graft failure. Points were assigned to known but easily determined risk factors (panel reactive antibody, flow crossmatch, delayed graft function) and calculated immediately after deceased donor kidney transplantation. Point totals were used to identify: 1) which patients would receive desensitization; and, 2) which regimen each patient would receive...
2014: Clinical Transplants
https://www.readbyqxmd.com/read/26274817/changing-kidney-allograft-histology-early-posttransplant-prognostic-implications-of-1-year-protocol-biopsies
#13
F G Cosio, M El Ters, L D Cornell, C A Schinstock, M D Stegall
Allograft histology 1 year posttransplant is an independent correlate to long-term death-censored graft survival. We assessed prognostic implications of changes in histology first 2 years posttransplant in 938 first kidney recipients, transplanted 1999-2010, followed for 93.4 ± 37.7 months. Compared to implantation biopsies, histology changed posttransplant showing at 1 year that 72.6% of grafts had minor abnormalities (favorable histology), 20.2% unfavorable histology, and 7.2% glomerulonephritis. Compared to favorable, graft survival was reduced in recipients with unfavorable histology (hazards ratio [HR] = 4...
January 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/26193627/peripheral-phenotype-and-gene-expression-profiles-of-combined-liver-kidney-transplant-patients
#14
MULTICENTER STUDY
Erwan Dumontet, Richard Danger, Parsia A Vagefi, Maria-Carlota Londoño, Annaïck Pallier, Juan José Lozano, Magali Giral, Nicolas Degauque, Jean-Paul Soulillou, Marc Martínez-Llordella, Herman Lee, Marianne Latournerie, Karim Boudjema, Joelle Dulong, Karin Tarte, Alberto Sanchez-Fueyo, Sandy Feng, Sophie Brouard, Sophie Conchon
BACKGROUND AND AIMS: The beneficial effect of one graft on another has been reported in combined transplantation but the associated mechanisms and biological influence of each graft have not yet been established. METHODS: In multiple analyses, we explored the PBMC phenotype and signature of 45 immune-related messenger RNAs and 754 microRNAs from a total of 235 patients, including combined liver-kidney transplant recipients (CLK), patients with a liver (L-STA) or kidney (K-STA) graft only under classical immunosuppression and patients with tolerated liver (L-TOL) or kidney grafts (K-TOL)...
March 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/26071493/capillary-c4d-and-kidney-allograft-outcome-in-relation-to-morphologic-lesions-suggestive-of-antibody-mediated-rejection
#15
Željko Kikić, Alexander Kainz, Nicolas Kozakowski, Rainer Oberbauer, Heinz Regele, Gregor Bond, Georg A Böhmig
BACKGROUND AND OBJECTIVES: Recent studies highlighting a role of C4d- antibody-mediated rejection (ABMR) have debated whether C4d staining has independent value as a rejection marker. Considering the presumed role of complement as an important effector of graft injury, this study hypothesized that capillary C4d, a footprint of antibody-triggered complement activation, indicates a particularly severe manifestation of ABMR. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This large retrospective clinicopathologic study sought to assess the clinical predictive value of C4d staining in relation to ABMR morphology...
August 7, 2015: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/25266215/role-of-allograft-nephrectomy-following-kidney-graft-failure-preliminary-experience-with-pre-operative-angiographic-kidney-embolization
#16
Samer M T Al-Geizawi, Rajinder P Singh, Jack M Zuckerman, Jay A Requarth, Alan C Farney, Jeffrey Rogers, Jacob Taussig, Giuseppe Orlando, Robert J Stratta
INTRODUCTION: Allograft nephrectomy (AN) is not without morbidity following graft failure (GF) in kidney transplantation (KT). METHODS: Single center retrospective review of all adult patients undergoing AN following KT, including a subset of patients who underwent pre-operative angiographic kidney embolization (PAKE). RESULTS: Over a 104 month period, 853 adult patients underwent deceased donor KT. With a median follow-up of 3.5 years, 174 patients (20...
June 2015: Journal of Nephrology
https://www.readbyqxmd.com/read/24903438/long-term-results-in-recipients-of-combined-hla-mismatched-kidney-and-bone-marrow-transplantation-without-maintenance-immunosuppression
#17
T Kawai, D H Sachs, B Sprangers, T R Spitzer, S L Saidman, E Zorn, N Tolkoff-Rubin, F Preffer, K Crisalli, B Gao, W Wong, H Morris, S A LoCascio, P Sayre, B Shonts, W W Williams, R-N Smith, R B Colvin, M Sykes, A B Cosimi
We report here the long-term results of HLA-mismatched kidney transplantation without maintenance immunosuppression (IS) in 10 subjects following combined kidney and bone marrow transplantation. All subjects were treated with nonmyeloablative conditioning and an 8- to 14-month course of calcineurin inhibitor with or without rituximab. All 10 subjects developed transient chimerism, and in seven of these, IS was successfully discontinued for 4 or more years. Currently, four subjects remain IS free for periods of 4...
July 2014: American Journal of Transplantation
https://www.readbyqxmd.com/read/24753207/antibody-mediated-rejection-in-kidney-transplantation-a-review-of-pathophysiology-diagnosis-and-treatment-options
#18
REVIEW
Miae Kim, Spencer T Martin, Keri R Townsend, Steven Gabardi
Antibody-mediated rejection (AMR), also known as B-cell-mediated or humoral rejection, is a significant complication after kidney transplantation that carries a poor prognosis. Although fewer than 10% of kidney transplant patients experience AMR, as many as 30% of these patients experience graft loss as a consequence. Although AMR is mediated by antibodies against an allograft and results in histologic changes in allograft vasculature that differ from cellular rejection, it has not been recognized as a separate disease process until recently...
July 2014: Pharmacotherapy
https://www.readbyqxmd.com/read/24741575/hla-g-dimers-in-the-prolongation-of-kidney-allograft-survival
#19
Maureen Ezeakile, Vera Portik-Dobos, Juan Wu, Daniel D Horuzsko, Rajan Kapoor, Muralidharan Jagadeesan, Laura L Mulloy, Anatolij Horuzsko
Human leukocyte antigen-G (HLA-G) contributes to acceptance of allografts in solid organ/tissue transplantation. Most studies have determined that soluble HLA-G isoforms are systematically detected in serum/plasma of transplanted patients with significantly fewer episodes of acute and/or chronic rejection of allogeneic tissue/organ. Current models of the interactions of HLA-G and its specific receptors explain it as functioning in a monomeric form. However, in recent years, new data has revealed the ability of HLA-G to form disulfide-linked dimeric complexes with high preferential binding and functional activities...
2014: Journal of Immunology Research
https://www.readbyqxmd.com/read/24463770/causes-and-prognostic-value-of-pre-transplant-elevated-kynurenine-level-in-kidney-allograft-recipients
#20
Jürgen Kaden, Dietmar Abendroth, Andreas Völp, Michael Marzinzig, Claus Wesslau
BACKGROUND: The activation of the tryptophane catabolizing enzyme Indoleamine 2,3-dioxygenase leads to the formation of kynurenine and other metabolites that counter-regulate immune activation resulting in restoration of immune homeostasis. But in chronic immune activation, as in hemodialysed patients, the immunosuppressive feedback mechanisms continue as indicated by elevated kynurenine concentrations. However, its relevance is still a matter of debate. MATERIAL/METHODS: This retrospective analysis presents the pre-transplant kynurenine levels (quantified photometrically) of 307 kidney graft recipients in connection with some pre- and post-transplant variables and the type of immunosuppression (cyclosporine-based triple drug therapy without/with ATG-Fresenius-induction)...
2014: Annals of Transplantation: Quarterly of the Polish Transplantation Society
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