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https://www.readbyqxmd.com/read/29045978/-clinicopathologic-features-of-infant-dysembryoplastic-neuroepithelial-tumor-a-case-report-and-literature-review
#1
H Wang, J T Ye, H X Yao, D Li, Y Dong
Dysembryoplastic neuroepithelial tumor (DNT) has traditionally been viewed as rare benign tumors that present with seizure widely considered curable with surgery alone. Most DNTs occur in childhood and young adults. However, rare reported cases occur in infants. This paper reported an infant case of DNT and its diagnosis, differential diagnosis, treatment, molecular features and prognosis based on the review of current literatures. The age onset of this patient was only 11 months old. The clinical manifestations were partial seizures and the imaging data untypical; CT and MRI were all supportive of astrocytoma...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045303/riluzole-serum-concentration-in-pediatric-patients-treated-for-obsessive-compulsive-disorder
#2
Paul Grant, Cristan Farmer, Jane Song, Timothy Kish, Susan Swedo
PURPOSE/BACKGROUND: The goals of this study were to determine whether pediatric serum concentration of riluzole is similar to that observed in adults and to determine whether riluzole serum concentration is associated with adverse effects or efficacy in children and adolescents with treatment-refractory obsessive-compulsive disorder. METHODS/PROCEDURES: Data were drawn from previously published studies: 1 open-label trial and 1 randomized controlled trial with an open-label extension phase...
October 17, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29045264/patterns-of-failure-in-patients-with-adult-medulloblastoma-presenting-without-extraneural-metastasis
#3
Meriem Mokhtech, Christopher G Morris, Daniel J Indelicato, Michael S Rutenberg, Robert J Amdur
OBJECTIVES: The objective of this study is to evaluate long-term outcomes, specifically patterns of tumor recurrence, in patients with adult medulloblastoma treated with radiotherapy. METHODS: We recorded outcomes of 28 (median age, 25 y) patients 18 years old or above with M0 to M3 medulloblastoma treated between 1971 and 2012. Among them, 61% had standard-risk disease. All received craniospinal irradiation with a posterior fossa boost. Median dose to the craniospinal axis was 36 Gy...
October 17, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29044832/understanding-acceptability-of-and-engagement-with-web-based-interventions-aiming-to-improve-quality-of-life-in-cancer-survivors-a-synthesis-of-current-research
#4
REVIEW
Teresa Corbett, Karmpaul Singh, Liz Payne, Katherine Bradbury, Claire Foster, Eila Watson, Alison Richardson, Paul Little, Lucy Yardley
PURPOSE: This review sought to summarize existing knowledge in order to inform the development of an online intervention that aims to improve quality of life after cancer treatment. METHODS: To inform our intervention, we searched for studies relating to web-based interventions designed to improve QoL in adults who have completed primary treatment for breast, prostate and colorectal cancer (as these are three of the most common cancers and impact a large number of cancer survivors)...
October 17, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29044764/estimated-glomerular-filtration-rate-and-the-risk-benefit-profile-of-intensive-blood-pressure-control-among-non-diabetic-patients-a-post-hoc-analysis-of-a-randomized-clinical-trial
#5
Yoshitsugu Obi, Kamyar Kalantar-Zadeh, Ayumi Shintani, Csaba P Kovesdy, Takayuki Hamano
BACKGROUND: The Systolic Blood Pressure Intervention Trial (SPRINT; ClinicalTrials. gov, NCT01206062) reported reduced cardiovascular events by intensive blood pressure (BP) control among hypertensive patients without diabetes. However, the risk-benefit profile of intensive BP control may differ across estimated glomerular filtration rate (eGFR) levels. METHODS: This is a post-hoc analysis of the SPRINT. Non-diabetic hypertensive adults (n=9,361) with eGFR >20 mL/min/1...
October 16, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29044737/chronic-bmy7378-treatment-alters-behavioral-circadian-rhythms
#6
Jhenkruthi Vijaya Shankara, Angélique Orr, Richelle Mychasiuk, Michael C Antle
The mammalian circadian clock is synchronized to the day:night cycle by light. Serotonin modulates the circadian effects of light, with agonists inhibiting response to light and antagonists enhancing responses to light. A special class of serotonergic compounds, the mixed 5-HT1A agonist/antagonists, potentiate light-induced phase advances by up to 400% when administered acutely. In this study, we examine the effects of one of these mixed 5-HT1A agonist/antagonists, BMY7378, when administered chronically. Thirty adult male hamsters were administered either vehicle or BMY7378 via surgically implanted osmotic minipumps over a period of 28 days...
October 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29044212/a-pilot-study-on-tocilizumab-for-treating-refractory-adult-onset-still-s-disease
#7
Ting Li, Liyang Gu, Xiaodong Wang, Li Guo, Hui Shi, Chengde Yang, Sheng Chen
To investigate the efficacy and safety of Tocilizumab (TCZ) in patients with refractory adult-onset Still's disease (AOSD). We enrolled 8 female patients from October 2013 to July 2014. All patients fulfilled Japan's Yamaguch AOSD classification and recognized as refractory AOSD. All Patients received TCZ treatment 4-8 mg/kg every 4 weeks. Evaluation of efficacy was conducted after 3 months and 6 months, including clinical manifestations of AOSD patients, improvement of inflammatory markers as well as glucocorticoids dosage adjustments...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043971/-what-are-the-treatment-needs-in-adults-an-evaluation-of-258-cases-by-the-iotn
#8
Sarah Gebeile-Chauty, William Birraux
INTRODUCTION: The aim of this epidemiological study was to evaluate the need for orthodontic treatment in a sample of adults living in France. MATERIALS AND METHODS: The indicator selected was the dental component, IOTN (index of orthodontic treatment need). RESULTS: Among the 258 adults evaluated, 37% of patients had a strong need and 21% had a moderate need; 29% of those aged 35 and under were in strong need for treatment compared with 47% of those over 35 years, with the need for treatment increasing with age...
September 2017: L' Orthodontie Française
https://www.readbyqxmd.com/read/29043488/hair-analysis-does-not-allow-to-discriminate-between-acute-and-chronic-administrations-of-a-drug-in-young-children
#9
Jean Claude Alvarez, Laetitia Lasne, Isabelle Etting, Gérard Chéron, Véronique Abadie, Nicolas Fabresse, Islam Amine Larabi
There are many differences between the hair from children and that of adult subjects, the hair being thinner, more porous with a different growth rate from the usual 1 cm/month observed in adults. In order to determine whether hair analysis could discriminate between chronic use and acute administration of a drug in children like in adults, we analyzed hair from 18 children aged between 1 day and 15 years in whom the administration of different drugs was known (single therapeutic administration or acute intoxication)...
October 18, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29043209/perianal-langerhans-cell-histiocytosis-a-rare-presentation-in-an-adult-male
#10
Asmaa Gaber Abdou, Doha MaherTaie
Langerhans cell histiocytosis (LCH) is a rare disease characterized by a proliferation of cells that show immunophenotypic and ultrastructural similarities with antigen-presenting Langerhans cells of mucosal sites and skin. LCH in adults is rare, and there are still many undiagnosed/misdiagnosed patients. We describe LCH involvement of the perianal region of a 33-year-old male with a previous history of diabetes insipidus. The differential diagnosis and all the reported cases of LCH of the perianal skin involvement since its description in 1984 till 2016 are discussed...
July 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/29043079/acute-coronary-syndromes-in-the-elderly
#11
REVIEW
Niels Engberding, Nanette K Wenger
The clinical evidence for treatment of acute coronary syndrome (ACS) in the elderly is less robust than in patients younger than 75 years. The elderly have the highest incidence of cardiovascular disease and frequently present with ACS. This number can be expected to increase over time because society is aging. Older adults often sustain unfavorable outcomes from ACS because of atypical presentation and delay in recognition. In addition, elderly patients commonly do not receive optimal guideline-directed ACS treatment...
2017: F1000Research
https://www.readbyqxmd.com/read/29042809/implementation-of-gina-guidelines-in-asthma-management-by-primary-care-physicians-in-vietnam
#12
Vinh Nhu Nguyen, Quynh Nhat Nguyen, Pham Le An, Niels H Chavannes
BACKGROUND: Asthma control is suboptimal in Vietnam. Lack of knowledge of primary care physicians (PCPs) for asthma management may potentially be one of the causes. PURPOSE: The aim of this study was to assess the knowledge and practice of PCPs' asthma management based on the Global Initiative for Asthma (GINA) guidelines (2015 update). METHODS: A cross-sectional study with convenience sampling was conducted among PCPs in an urban and rural area of Vietnam using questionnaires related to asthma patients daily practice: use of spirometry and the asthma control test (ACT), prescription of asthma medications, and frequency of consultations...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/29042362/comparative-safety-of-direct-oral-anticoagulants-and-warfarin-in-venous-thromboembolism-multicentre-population-based-observational-study
#13
Min Jun, Lisa M Lix, Madeleine Durand, Matt Dahl, J Michael Paterson, Colin R Dormuth, Pierre Ernst, Shenzhen Yao, Christel Renoux, Hala Tamim, Cynthia Wu, Salaheddin M Mahmud, Brenda R Hemmelgarn
Objective To determine the safety of direct oral anticoagulant (DOAC) use compared with warfarin use for the treatment of venous thromboembolism.Design Retrospective matched cohort study conducted between 1 January 2009 and 31 March 2016.Setting Community based, using healthcare data from six jurisdictions in Canada and the United States.Participants 59 525 adults (12 489 DOAC users; 47 036 warfarin users) with a new diagnosis of venous thromboembolism and a prescription for a DOAC or warfarin within 30 days of diagnosis...
October 17, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29042332/the-relevance-of-simpson-grade-resectionsin-the-modern-neurosurgical-treatment-of-world-health-organization-grade-1-2-and-3meningiomas
#14
Jeff S Ehresman, Tomas Garzon-Muvdi, Davis Rogers, Michael Lim, Gary L Gallia, Jon Weingart, Henry Brem, Chetan Bettegowda, Kaisorn L Chaichana
OBJECT: The Simpson grading system has played an important role in the surgical resections of meningiomas. This study set out to determine if this grading system predicts meningioma recurrence in a modern cohort of patients with tumors of all World Health Organization (WHO) grades. METHODS: Adult patients who underwent primary, non-biopsy resection of a meningioma at a tertiary care institution between 2007 and 2015 were retrospectively reviewed. Stepwise multivariate proportional hazard analyses were used to identify associations with recurrence following resection...
October 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29042032/clinical-outcomes-and-predictors-of-patient-satisfaction-in-displaced-midshaft-clavicle-fractures-in-adults-results-from-a-retrospective-multicentre-study
#15
Eric D Tutuhatunewa, Martin Stevens, Ron L Diercks
BACKGROUND: The optimal treatment of displaced midshaft clavicle fractures (Robinson Type 2B1 & 2B2) in adults remains controversial. Little is known about patient satisfaction with treatment for this type of injury. The purpose of this study was to compare clinical outcomes and explore predictors of patient satisfaction after nonoperative and direct-operative treatment of displaced midshaft clavicle fractures in adults. METHODS: A retrospective multicentre study was conducted...
October 7, 2017: Injury
https://www.readbyqxmd.com/read/29041008/increase-of-substance-p-concentration-in-saliva-after-pharyngeal-electrical-stimulation-in-severely-dysphagic-stroke-patients-an-indicator-of-decannulation-success
#16
Paul Muhle, Sonja Suntrup-Krueger, Stefan Bittner, Tobias Ruck, Inga Claus, Thomas Marian, Jens B Schröder, Jens Minnerup, Tobias Warnecke, Sven G Meuth, Rainer Dziewas
BACKGROUND/AIMS: Substance P (SP) is a neuropeptide, likely acting as a neurotransmitter in the pharyngeal mucosa enhancing the swallow and cough reflex. Pharyngeal Electrical Stimulation (PES) induces a temporary increase of salivary SP levels in healthy adults. Previous evidence suggests that post-stroke dysphagia is related to reduced SP levels. Here, we investigated the effects of PES on SP levels in severely dysphagic stroke patients and a possible link between increase of SP and treatment success...
October 17, 2017: Neuro-Signals
https://www.readbyqxmd.com/read/29040956/antihyperlipidemic-effect-of-pistacia-khinjuk
#17
Faiza Kamal, Muhammad Shahzad, Tanveer Ahmad, Zaheer Ahmed, Rasool Bakhash Tareen, Rabiya Naz, Ali Ahmad
BACKGROUND: Hyperlipidemia is a metabolic disorder that is caused by high levels of triglycerides and cholesterol in blood. Using of plants for the treatment of various ailments is a traditional practice in developing countries. The main objective of the study is to analyse the nutritional composition of Pistacia khinjuk and to assess its anti-hyperlipidemic activity. MATERIALS AND METHODS: In the present study, the ethanolic extract of Pistacia khinjuk leaves was evaluated for antihyperlipidemic activity...
October 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29040827/effects-of-lorcaserin-belviq-%C3%A2-on-nicotine-and-food-maintained-responding-in-non-human-primates
#18
David S Jacobs, Claire E Barkin, Michelle R Kohut, Jack Bergman, Stephen J Kohut
BACKGROUND: Accumulating evidence suggests that the FDA-approved serotonin 5-HT2C receptor agonist, lorcaserin (Belviq(®)), may be a promising candidate for the management of substance use disorders, including nicotine addiction. The present study was conducted to determine the efficacy and selectivity of acute or continuous lorcaserin treatment for decreasing the reinforcing effects of nicotine in a primate species. METHODS: Adult rhesus monkeys (n=4) with a history of nicotine self-administration (>2years) responded for injections of nicotine (0...
October 10, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29040512/fertility-related-knowledge-and-reproductive-goals-in-childhood-cancer-survivors-short-communication
#19
V Lehmann, M C Keim, L Nahata, E L Shultz, J L Klosky, M A Tuinman, C A Gerhardt
STUDY QUESTION: Do young adult survivors of childhood cancer know their fertility status, in the context of their parenthood goals and screening for gonadal functioning? SUMMARY ANSWER: While 80% of survivors (who were without children) wanted children in the future, most did not know their fertility status, and screening for gonadal functioning was underutilized. WHAT IS KNOWN ALREADY: Survivors of childhood cancer are at risk for infertility, but fertility counseling and assessment are underutilized...
September 29, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040331/primary-care-models-for-treating-opioid-use-disorders-what-actually-works-a-systematic-review
#20
Pooja Lagisetty, Katarzyna Klasa, Christopher Bush, Michele Heisler, Vineet Chopra, Amy Bohnert
BACKGROUND: Primary care-based models for Medication-Assisted Treatment (MAT) have been shown to reduce mortality for Opioid Use Disorder (OUD) and have equivalent efficacy to MAT in specialty substance treatment facilities. OBJECTIVE: The objective of this study is to systematically analyze current evidence-based, primary care OUD MAT interventions and identify program structures and processes associated with improved patient outcomes in order to guide future policy and implementation in primary care settings...
2017: PloS One
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