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https://www.readbyqxmd.com/read/29677354/retinoic-acid-maintains-function-of-neural-crest-derived-ocular-and-craniofacial-structures-in-adult-zebrafish
#1
Bahaar Chawla, William Swain, Antionette L Williams, Brenda L Bohnsack
Purpose: Retinoic acid (RA) is required for embryonic formation of the anterior segment of the eye and craniofacial structures. The present study further investigated the role of RA in maintaining the function of these neural crest-derived structures in adult zebrafish. Methods: Morphology and histology were analyzed by using live imaging, methylacrylate sections, and TUNEL assay. Functional analysis of vision and aqueous humor outflow were assayed with real-time imaging...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677148/oxygen-consumption-and-acoustic-activity-of-adult-callosobruchus-maculatus-f-coleoptera-chrysomelidae-bruchinae-during-hermetic-storage
#2
Anastasia W Njoroge, Richard W Mankin, Bradley W Smith, Dieudonne Baributsa
Acoustic monitoring was applied to consider hermetic exposure durations and oxygen levels required to stop adult Callosobruchus maculatus activity and economic damage on cowpea. A 15-d study was conducted with six treatments of 25, 50, and 100 C. maculatus adults in 500 and 1000 mL jars using acoustic probes inserted through stoppers sealing the jars. Acoustic activity as a result of locomotion, mating, and egg-laying was measured by identifying sound impulses with frequency spectra representative of known insect sounds, and counting trains (bursts) of impulses separated by intervals of <200 ms, that typically are produced only by insects...
April 20, 2018: Insects
https://www.readbyqxmd.com/read/29676534/consensus-based-european-guidelines-for-treatment-of-atopic-eczema-atopic-dermatitis-in-adults-and-children-part-i
#3
A Wollenberg, S Barbarot, T Bieber, S Christen-Zaech, M Deleuran, A Fink-Wagner, U Gieler, G Girolomoni, S Lau, A Muraro, M Czarnecka-Operacz, T Schäfer, P Schmid-Grendelmeier, D Simon, Z Szalai, J C Szepietowski, A Taïeb, A Torrelo, T Werfel, J Ring
This guideline was developed as a joint interdisciplinary European project, including physicians from all relevant disciplines as well as patients. It is a consensus-based guideline, taking available evidence from other guidelines, systematic reviews and published studies into account. This first part of the guideline covers methods, patient perspective, general measures and avoidance strategies, basic emollient treatment and bathing, dietary intervention, topical anti-inflammatory therapy, phototherapy and antipruritic therapy, whereas the second part covers antimicrobial therapy, systemic treatment, allergen-specific immunotherapy, complementary medicine, psychosomatic counselling and educational interventions...
May 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29676530/short-and-long-term-changes-in-health-related-quality-of-life-with-weight-loss-results-from-a-randomized-controlled-trial
#4
Rebecca L Pearl, Thomas A Wadden, Jena Shaw Tronieri, Robert I Berkowitz, Ariana M Chao, Naji Alamuddin, Sharon M Leonard, Raymond Carvajal, Zayna M Bakizada, Emilie Pinkasavage, Kathryn A Gruber, Olivia A Walsh, Nasreen Alfaris
OBJECTIVE: The objective of this study was to determine the effects of weight loss and weight loss maintenance (WLM) on weight-specific health-related quality of life in a 66-week trial. METHODS: Adults with obesity (N = 137, 86.1% female, 68.6% black, mean age = 46.1 years) who had lost ≥ 5% of initial weight in a 14-week intensive lifestyle intervention/low-calorie diet (LCD) program were randomly assigned to lorcaserin or placebo for an additional 52-week WLM program...
April 20, 2018: Obesity
https://www.readbyqxmd.com/read/29676439/oral-and-sublingual-immunotherapy-for-egg-allergy
#5
REVIEW
Olga Romantsik, Maria Angela Tosca, Simona Zappettini, Maria Grazia Calevo
BACKGROUND: Clinical egg allergy is a common food allergy. Current management relies upon strict allergen avoidance. Oral immunotherapy might be an optional treatment, through desensitization to egg allergen. OBJECTIVES: To determine the efficacy and safety of oral and sublingual immunotherapy in children and adults with immunoglobulin E (IgE)-mediated egg allergy as compared to a placebo treatment or an avoidance strategy. SEARCH METHODS: We searched 13 databases for journal articles, conference proceedings, theses and trials registers using a combination of subject headings and text words (last search 31 March 2017)...
April 20, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29675987/the-usage-of-procalcitonin-in-finland
#6
B Tujula, M Kokki, K Pulkki, J Romppanen, S Sjövall, H Tuominen, H Kokki
BACKGROUND: We have surveyed the use of procalcitonin (PCT) in Finland with a specific emphasis on intensive care unit (ICU) patients. METHODS: The PCT use was surveyed from all 11 laboratories providing services for all 15 secondary and all five tertiary care hospitals in Finland. The laboratories reported the PCT use of each hospital in 2014 and 2015. Four hospitals were analysed for the first 100 adult ICU patients with PCT measurements in 2015. The indication for PCT measurement and whether PCT values affected antibiotic treatment were collected from patient records...
April 19, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29675951/genomic-profiling-of-anaplastic-meningioma-identifies-recurrent-genetic-alterations-with-relevance-to-lower-grade-meningioma
#7
Patrick J Cimino, Rebecca A Yoda, Hans-Georg Wirsching, Joshua I Warrick, Michael O Dorschner, Manuel Ferriera
Meningiomas are the most common primary intracranial tumor in adults [1]. The majority of meningiomas are histologically and clinically benign and can be cured by gross total surgical resection [2]. Current histopathology-based grading does not account for a subset of meningiomas with benign histology, but nonetheless aggressive clinical behavior and a need for additional treatment [3]. This article is protected by copyright. All rights reserved.
April 19, 2018: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29675841/early-life-conditions-that-impact-song-learning-in-male-zebra-finches-also-impact-neural-and-behavioral-responses-to-song-in-females
#8
Kendra B Sewall, Rindy C Anderson, Jill A Soha, Susan Peters, Stephen Nowicki
Early life stressors can impair song in songbirds by negatively impacting brain development and subsequent learning. Even in species in which only males sing, early life stressors might also impact female behavior and its underlying neural mechanisms, but fewer studies have examined this possibility. We manipulated brood size in zebra finches to simultaneously examine the effects of developmental stress on male song learning and female behavioral and neural response to song. Although adult male HVC volume was unaffected, we found that males from larger broods imitated tutor song less accurately...
April 20, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29675797/treatment-intensification-in-type-2-diabetes-a-real-world-study-of-2-oad-regimens-glp-1-ras-or-basal-insulin
#9
Lawrence Blonde, Denis Raccah, Elisheva Lew, Juliana Meyers, Elena Nikonova, Mayank Ajmera, Keith L Davis, Monica Bertolini, Bruno Guerci
INTRODUCTION: Treatment guidelines recommend a stepwise approach to glycemia management in patients with type 2 diabetes (T2D), but this may result in uncontrolled glycated hemoglobin A1c (HbA1c) between steps. This retrospective analysis compared clinical and economic outcomes among patients with uncontrolled T2D initiating two oral antidiabetes drugs (OADs), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), or basal insulin in a real-world setting. METHODS: Adults with T2D on OAD monotherapy were identified in the MarketScan claims database (2007-2014)...
April 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29675752/preliminary-report-on-endoscopic-pilonidal-sinus-treatment-in-children-results-of-a-multicentric-series
#10
Alessio Pini Prato, Cinzia Mazzola, Girolamo Mattioli, Maria Escolino, Ciro Esposito, Antonio D'Alessio, Laura Caterina Abati, Lorenzo Leonelli, Claudio Carlini, Franco Rotundi, Pier Carlo Meinero
BACKGROUND: Pilonidal disease is a troublesome acquired condition for whom various surgical treatments have been proposed with relatively high recurrence and complication rates. Since EPSiT technique has been described in 2013, it became an alternative treatment in adult practice. Our study reports the results of a multicentre series of pediatric patients who underwent EPSiT procedure over a 21-month period. METHODS: Between July 2015 and March 2017, all consecutive patients undergoing EPSiT in four different pediatric surgical units have been enrolled...
April 19, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29675548/exercise-headache-a-review
#11
REVIEW
Claire H Sandoe, William Kingston
PURPOSE OF REVIEW: Exercise headache refers to headache that is triggered by exercise or exertion. Although secondary causes must be excluded, most cases of exercise headache are benign, idiopathic, and self-limited. This article reviews the revised diagnostic criteria for primary exercise headache (PEH) and discusses recent research into the clinical presentation, epidemiology, pathophysiology, suggested workup, and treatment of this condition. RECENT FINDINGS: Recent studies estimate that PEH affects from 1 to 26% of the adult population...
April 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29674772/total-hip-arthroplasty-for-patients-with-residual-poliomyelitis-at-a-mean-eight-years-of-follow-up
#12
Mayumi Sonekatsu, Motoki Sonohata, Masaru Kitajima, Shunsuke Kawano, Masaaki Mawatari
In patients with poliomyelitis, degenerative arthritis of the hip may be encountered in the paralytic or normal contralateral limb because of leg length discrepancy, pelvic obliquity, or severe deformities of the affected hip. Although total hip arthroplasty (THA) is one of the most common orthopedic procedures, there are few reports of THA in adult patients with residual poliomyelitis. From March 2001 to January 2011, 5 patients with residual poliomyelitis (6 hips) underwent THA using uncemented implants at our hospital...
April 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29674329/regional-variability-in-fecal-microbiota-transplantation-practices-a-survey-of-the-southern-ontario-fecal-microbiota-transplantation-movement
#13
Susy S Hota, Salman Surangiwala, Aimee S Paterson, Bryan Coburn, Susan M Poutanen
BACKGROUND: There is growing evidence that fecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile infection, but little guidance exists for implementation of FMT programs. The objective of this study is to describe the program characteristics and protocols of 9 planned or operating FMT programs in the Southern Ontario Fecal Microbiota Transplantation (SOFT) Movement, to help guide future FMT program implementation. METHODS: A 59-item survey was administered electronically to clinical leads of the SOFT Movement on June 2, 2016...
April 18, 2018: CMAJ Open
https://www.readbyqxmd.com/read/29673891/burden-of-acute-myeloid-leukemia-among-older-newly-diagnosed-patients-retrospective-analysis-of-data-from-the-2010-2012-medicare-limited-data-set
#14
Naomi C Sacks, Philip L Cyr, Arthur C Louie, Yanmei Liu, Michael T Chiarella, Abhishek Sharma, Karen C Chung
PURPOSE: Acute myeloid leukemia (AML) disproportionately affects older adults; the prognosis in this subpopulation is generally poor, with variable use of inpatient chemotherapy. This study characterizes treatment patterns, hospitalizations, and outcomes among older patients with AML. METHODS: Using the Centers for Medicare & Medicaid Services' 2010-2012 100% Limited Data Set (LDS), data from all hospital claims from fee-for-service Medicare beneficiaries between 60 and 75 years of age with newly diagnosed AML and ≥1 hospitalization were analyzed...
April 16, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29673470/hypertension-across-a-woman-s-life-cycle
#15
REVIEW
Nanette K Wenger, Anita Arnold, C Noel Bairey Merz, Rhonda M Cooper-DeHoff, Keith C Ferdinand, Jerome L Fleg, Martha Gulati, Ijeoma Isiadinso, Dipti Itchhaporia, KellyAnn Light-McGroary, Kathryn J Lindley, Jennifer H Mieres, Mary L Rosser, George R Saade, Mary Norine Walsh, Carl J Pepine
Hypertension accounts for 1 in 5 deaths among American women, posing a greater burden for women than men, and is among their most important risk factors for death and development of cardiovascular and other diseases. Hypertension affects women in all phases of life, with specific characteristics relating to risk factors and management for primary prevention of hypertension in teenage and young adult women; hypertension in pregnancy; hypertension during use of oral contraceptives and assisted reproductive technologies, lactation, menopause, or hormone replacement; hypertension in elderly women; and issues of race and ethnicity...
April 24, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29673452/-modified-cheng-s-juanbi-decoction-reduces-camp-level-of-t-lymphocytes-in-peripheral-blood-and-cd4-cd8-t-cell-ratio-among-rats-with-adjuvant-arthritis
#16
Xia Xu, Huan DU, Yalan Wu, Hui Cheng, Jian Cao, Qingwei Meng, Mengyuan Guo
Objective To investigate the effects of modified Cheng's Juanbi Decoction (CJBD) on the level of cAMP in T lymphocytes and CD4+ /CD8+ T cell ratio among rats with adjuvant arthritis (AA). Methods Male adult SD rats were randomly divided into normal control group, AA group, CJBD group, and tripterygium glycosides tablet (TGT) group. Blowing/cold water and Freund's complete adjuvant were used to establish a rat model of AA with wind-cold-dampness arthralgia. The control group was given normal saline by gavage, and the CJBD group and TGT group were given respective therapies...
February 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29673371/radiographic-and-clinical-outcomes-following-mis-tlif-in-patients-with-adult-lumbar-degenerative-scoliosis
#17
Yongfei Zhao, Yan Liang, Keya Mao
BACKGROUND: Patients suffering from adult lumbar degenerative scoliosis (ALDS) are commonly complicated with advanced age, osteoporosis, cardiopulmonary insufficiency, and some other medical comorbidity. Therefore, the traditional open surgery can lead to high rate of postoperative complications. The purposes of this study were to introduce our experiences and explore the efficacy and feasibility of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in the treatment of patients with ALDS...
April 19, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29673070/mycn-is-a-novel-oncogenic-target-in-adult-b-all-that-activates-the-wnt-%C3%AE-catenin-pathway-by-suppressing-dkk3
#18
Desheng Kong, Linlin Zhao, Lili Sun, Shengjin Fan, Huibo Li, Yanqiu Zhao, Zhibo Guo, Leilei Lin, Lin Cui, Ke Wang, Wenjia Chen, Yihui Zhang, Jin Zhou, Yinghua Li
Dickkopf-3 (DKK3) is frequently down-regulated by promoter hypermethylation and is closely associated with a poor prognosis in many cancers. Our previous studies have shown that miR-708 down-regulates DKK3 at the post-transcriptional level in B-ALL. However, whether transcriptional mechanisms lead to DKK3 silencing remains unclear. Here, we analysed the promoter regions of DKK3 by bioinformatics and found binding sites for MYCN. A dual-luciferase reporter gene assay and ChIP experiments revealed that MYCN negatively regulates DKK3 at the transcriptional level in B-ALL cell lines, and using bisulphite sequencing PCR, we affirmed that MYCN has no effect on the methylation of the DKK3 promoter...
April 19, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29672852/responses-of-insect-herbivores-and-their-food-plants-to-wind-exposure-and-the-importance-of-predation-risk
#19
Cong Chen, Arjen Biere, Rieta Gols, Wouter Halfwerk, Kees van Oers, Jeffrey A Harvey
1.Wind is an important abiotic factor that influences an array of biological processes, but it is rarely considered in studies on plant-herbivore interactions. 2.Here, we tested whether wind exposure could directly or indirectly affect the performance of two insect herbivores, Plutella xylostella and Pieris brassicae, feeding on Brassica nigra plants. 3.In a greenhouse study using a factorial design, B. nigra plants were exposed to different wind regimes generated by fans before and after caterpillars were introduced on plants in an attempt to separate the effects of direct and indirect wind exposure on herbivores...
April 19, 2018: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29672542/attrition-when-providing-antiretroviral-treatment-at-cd4-counts-500cells-%C3%AE-l-at-three-government-clinics-included-in-the-hptn-071-popart-trial-in-south-africa
#20
Peter Bock, Geoffrey Fatti, Nathan Ford, Karen Jennings, James Kruger, Colette Gunst, Françoise Louis, Nelis Grobbelaar, Kwame Shanaube, Sian Floyd, Ashraf Grimwood, Richard Hayes, Helen Ayles, Sarah Fidler, Nulda Beyers
INTRODUCTION: WHO recommends antiretroviral treatment (ART) for all HIV-positive individuals. This study evaluated the association between baseline CD4 count and attrition in a cohort of HIV positive adults initiating ART at three department of health (DOH) clinics routinely providing ART at baseline CD4 counts >500cells/μL for the HPTN 071 (PopART) trial. METHODS: All clients attending the DOH clinics were managed according to standard care guidelines with the exception that those starting ART outside of pertinent local guidelines signed research informed consent...
2018: PloS One
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