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Papillary thyroid

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https://www.readbyqxmd.com/read/29792101/utility-of-a-novel-elastic-traction-system-in-endoscopic-thyroidectomy-via-breast-approach-initial-experience-with-34-patients
#1
Yi-Jun Lyu, Fang Shen, Hai Zhang, Gao-Xiang Chen
Objective To summarize our experiences in using an elastic traction, space-making technique for endoscopic thyroidectomy via breast approach in the treatment of early-stage differentiated papillary thyroid carcinoma. Methods A retrospective analysis was performed on patients who underwent endoscopic thyroidectomy via breast approach for thyroid carcinoma in our department. We used our self-developed "mini elastic traction space-maker" in a group of 34 patients; another 45 patients who underwent the procedure with the conventional CO2 insufflation method were enlisted as the control group...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29791660/potential-role-of-sorafenib-as-neoadjuvant-therapy-in-unresectable-papillary-thyroid-cancer
#2
Debora L S Danilovic, Gilberto Castro, Felipe S R Roitberg, Felipe A B Vanderlei, Fernanda A Bonani, Ricardo M C Freitas, George B Coura-Filho, Rosalinda Y Camargo, Marco A Kulcsar, Suemi Marui, Ana O Hoff
Total thyroidectomy, radioiodine (RAI) therapy, and TSH suppression are the mainstay treatment for differentiated thyroid carcinomas (DTCs). Treatments for metastatic disease include surgery, external-beam radiotherapy, RAI, and kinase inhibitors for progressive iodine-refractory disease. Unresectable locoregional disease remains a challenge, as standard therapy with RAI becomes unfeasible. We report a case of a young patient who presented with unresectable papillary thyroid carcinoma (PTC), and treatment with sorafenib allowed total thyroidectomy and RAI therapy...
May 17, 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29791655/accuracy-of-sentinel-lymph-node-mapping-in-detecting-occult-neck-metastasis-in-papillary-thyroid-carcinoma
#3
Jose Higino Steck, Elaine Stabenow, Gustavo Baldove Bettoni, Samuel Steck, Claudio Roberto Cernea
OBJECTIVES: The objectives of this study were to evaluate the following: 1) the accuracy of sentinel lymph node mapping (SLNM) in detecting metastasis in papillary thyroid carcinoma (PTC), and 2) if SLNM could modify the American Joint Committee on Cancer (AJCC) staging of previous cN0 PTC patients. SUBJECTS AND METHODS: Forty SLNM were performed prospectively in 38 consecutive cN0 PTC patients, with total thyroidectomy and elective compartment neck dissection (CND)...
May 17, 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29791602/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-achieving-better-agreement-by-refining-diagnostic-criteria
#4
EDITORIAL
Venancio A F Alves, Kennichi Kakudo, Virginia LiVolsi, Ricardo V Lloyd, Yuri E Nikiforov, Vania Nosé, Mauro Papotti, Lester D R Thompson
No abstract text is available yet for this article.
May 21, 2018: Clinics
https://www.readbyqxmd.com/read/29791034/high-expression-of-cd10-in-anaplastic-thyroid-carcinomas
#5
Tadao Nakazawa, Tetsuo Kondo, Huy Gia Vunong, Toru Odate, Masataka Kawai, Ippei Tahara, Kazunari Kasai, Tomohiro Inoue, Naoki Oishi, Kunio Mochizuki, Koichi Ito, Ryohei Katoh
AIMS: CD10 is an endopeptidase that degrades variable bioactive peptides in extra-cellular matrix. In addition to the enzymatic degradation, it affects multiple intra-cellular signal transduction pathways. CD10 expression has been extensively studied in human epithelial cancers of numerous organs and sites. However, its presence is not fully determined in thyroid carcinomas, especially in anaplastic thyroid carcinoma (ATC). METHODS AND RESULTS: We examined CD10 by immunohistochemistry (IHC) in 152 thyroid lesions: 9 adenomatous goiters (AGs) and 143 tumors including 47 anaplastic carcinomas...
May 23, 2018: Histopathology
https://www.readbyqxmd.com/read/29790216/decreased-expression-of-hsa_circ_0137287-predicts-aggressive-clinicopathologic-characteristics-in-papillary-thyroid-carcinoma
#6
Xiabin Lan, Jun Cao, Jiajie Xu, Chao Chen, Chuanming Zheng, Jiafeng Wang, Xuhang Zhu, Xin Zhu, Minghua Ge
BACKGROUND: Circular RNA (circRNA) is a new type of noncoding RNA that can serve as ideal biomarkers. Evidence has showed that circRNAs play an important role in carcinogenesis and cancer development. However, little is known about the diagnostic value of circRNAs in papillary thyroid carcinoma (PTC) as well as their associations with clinicopathologic characteristics of patients with PTC. METHODS: The expression levels of hsa_circ_0137287 were detected in 120 PTC and 60 adjacent noncancerous thyroid tissues by quantitative real-time polymerase chain reaction...
May 22, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29788738/hashimoto-s-thyroiditis-nodular-goiter-or-follicular-adenoma-combined-with-papillary-thyroid-carcinoma-play-protective-role-in-patients
#7
H Ma, L Li, K Li, T Wang, Y Zhang, C Zhang, Y Xu, X Wu, J Yu, H Wang, B Xiang, R Zhang, W Wang
Papillary thyroid carcinoma (PTC) is often combined with other types of thyroid disease, such as Hashimoto's thyroiditis(HT), nodular goiter(NG), Follicular adenoma(FA) and other types. However, the function of these diseases in PTC tumorigenesis and development is not well understood. In this research, 563 PTC patients were recruited and divided into two groups according to pathological diagnosis, namely simple PTC (PTC) and PTC combined with other thyroid diseases (PTC+). Clinicopathological characteristics and BRAFV600E mutation status were compared between PTC and PTC+...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29786427/diallyl-trisulfide-induces-apoptosis-of-human-papillary-thyroid-carcinoma-bcpap-cells-through-activating-mapk-signaling-pathway
#8
Jie Pan, Li Zhang, Shichen Xu, Xian Cheng, Huixin Yu, Jiandong Bao, Rong-Rong Lu
This study aimed to elucidate the potential effects of diallyl trisulfide (DATS) on human papillary thyroid carcinoma BCPAP cells and its underling mechanisms. DATS is one of the organosulfur compounds which derived from garlic. In this study, we demonstrated that compared to the solvent control, DATS treatment at concentrations of 5, 10 and 20 μΜ decreased cell survival rate of BCPAP cells to 84.51 ± 2.67%, 57.16 ± 1.18%, 41.22 ± 1.19% respectively. DATS also caused cell cycle arrest at G0/G1 phase and the proportion of cells arrested in G0/G1 phase rose from 68...
May 22, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29786126/prophylactic-central-compartment-neck-dissection-in-papillary-thyroid-cancer-and-effect-on-locoregional-recurrence
#9
David T Hughes, Jennifer E Rosen, Douglas B Evans, Elizabeth Grubbs, Tracy S Wang, Carmen C Solórzano
BACKGROUND: Prophylactic central compartment neck dissection (pCCND) in addition to total thyroidectomy (TT) includes removal of central compartment lymph nodes in the absence of clinical involvement on preoperative and intraoperative evaluation. The data regarding the influence of pCCND on oncologic outcomes and surgical complication rates is mixed and, therefore, is the focus of this analysis. METHODS: A systematic review of the literature on total thyroidectomy with prophylactic central compartment neck dissection (TT + pCCND) from January 1990 to October 2017 identified 221 abstracts of which 17 met inclusion criteria and were reviewed (1 randomized-control trial, 13 retrospective cohort studies, and 3 meta-analyses)...
May 21, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29785209/acute-suppurative-thyroiditis-caused-by-thyroid-papillary-carcinoma-in-the-right-thyroid-lobe-of-a-healthy-woman
#10
Hazuki Otani, Masakazu Notsu, Sayo Koike, Miwa Morita, Masahiro Yamamoto, Mika Yamauchi, Takahumi Fuchiwaki, Ichiro Morikura, Noriaki Aoi, Hideyuki Kawauchi, Teruaki Iwabashi, Asuka Araki, Noriyoshi Ishikawa, Riruke Maruyama, Toshitsugu Sugimoto
Background: The thyroid gland is resistant to microbial infection, because of its organ characteristics such as encapsulation, iodine content, and rich blood supply. Therefore, acute suppurative thyroiditis (AST), as a bacterial infection of the thyroid gland, is rarely seen. AST typically takes places on the left side the neck region in children, because of the coincidence of the left piriform sinus fistula, as a most common route of infection. AST is also usually seen in immunocompromised hosts...
2018: Thyroid Research
https://www.readbyqxmd.com/read/29785019/cribriform-morular-variant-of-thyroid-carcinoma-a-neoplasm-with-distinctive-phenotype-associated-with-the-activation-of-the-wnt-%C3%AE-catenin-pathway
#11
REVIEW
José Manuel Cameselle-Teijeiro, Diego Peteiro-González, Javier Caneiro-Gómez, María Sánchez-Ares, Ihab Abdulkader, Catarina Eloy, Miguel Melo, Isabel Amendoeira, Paula Soares, Manuel Sobrinho-Simões
Cribriform-morular variant of thyroid carcinoma is classically associated with familial adenomatous polyposis but, it can also occur as a sporadic neoplasm. This neoplasm is much more frequently observed in women than in men (ratio of 61:1). In familial adenomatous polyposis patients, tumors are generally multifocal and/or bilateral (multinodular appearance), whereas in the sporadic cases tumors tend to occur as single nodules. The tumors are well delimited, and characteristically show a blending of follicular, cribriform, papillary, trabecular, solid, and morular patterns...
May 21, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29783802/-clinicopathologic-and-molecular-features-of-cribriform-morular-variant-of-papillary-thyroid-carcinoma
#12
X J Cui, H O Zhao, P Su, J Chen, R Y Zhang, Y Pan, X M Ouyang, J Liu, J Q Zhang, Y Yang, R Yang, L Ding, Z Y Liu
Objective: To investigate the clinicopathologic and molecular features of the rare cribriform morular variant of papillary thyroid carcinoma (CMV-PTC). Methods: The clinicopathologic data of 10 patients with CMV-PTC were retrospectively reviewed. Immunohistochemical (IHC) staining was done using LSAB method. DNA sequencing for APC were applied using Sanger method. BRAF V600E mutation was examined using ARMS method. The cytological, morphological, IHC and molecular features were analyzed. Results: All patients were female at an average age of 27 years old...
May 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29783666/the-long-non-coding-rna-rp5-1024c24-1-and-its-associated-gene-mpped2-are-down-regulated-in-human-thyroid-neoplasias-and-act-as-tumour-suppressors
#13
Romina Sepe, Simona Pellecchia, Pierre Serra, Daniela D'Angelo, Antonella Federico, Maddalena Raia, Ricardo Cortez Cardoso Penha, Myriam Decaussin-Petrucci, Luigi Del Vecchio, Alfredo Fusco, Pierlorenzo Pallante
Background : Well-differentiated papillary thyroid carcinoma (PTC) represents the thyroid neoplasia with the highest incidence. Long non-coding RNAs (lncRNAs) have been found deregulated in several human carcinomas, and hence, proposed as potential diagnostic and prognostic markers. Therefore, the aim of our study was to investigate their role in thyroid carcinogenesis. Methods : We analysed the lncRNA expression profile of 12 PTC and four normal thyroid tissues through a lncRNA microarray. Results : We identified 669 up- and 2470 down-regulated lncRNAs with a fold change >2...
May 18, 2018: Cancers
https://www.readbyqxmd.com/read/29781213/thyroid-microcalcifications-in-the-absence-of-identifiable-nodules-and-their-association-with-thyroid-cancer
#14
Carolina Whittle, Marisol García, Eleonora Horvath, Jeannie Slater, Carmen Carrasco
OBJECTIVES: To determine ultrasound (US) and clinical findings of thyroid microcalcifications in the absence of a nodule and their association with the risk of malignancy. METHODS: The Institutional Review Board approved a 5-year retrospective study. Twenty-one patients with clustered or scattered thyroid microcalcifications in the absence of nodules on US images who underwent fine-needle aspiration biopsies (FNABs) were included. Demographic and clinical data, US findings, and pathologic results were registered...
May 21, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29778126/is-parenteral-levothyroxine-therapy-safe-in-intractable-hypothyroidism
#15
Hande Peynirci, Bengur Taskiran, Erdinc Erturk, Pınar Sisman, Canan Ersoy
CASE: A 32-year old woman was admitted to the hospital due to intractable hypothyroidism refractory to high dose of oral l-thyroxine therapy. She underwent total thyroidectomy and radioactive iodine therapy due to papillary thyroid cancer. After excluding poor adherence to therapy and malabsorption, levothyroxine absorption test was performed. No response was detected. Transient neurologic symptoms developed during the test. She developed 3 attacks consisting of neurologic symptoms during high dose administration...
June 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29776698/transoral-videolaryngoscopic-surgery-for-papillary-carcinoma-arising-in-lingual-thyroid
#16
Chisato Mogi, Hirotaka Shinomiya, Natsumi Fujii, Tomoyuki Tsuruta, Naruhiko Morita, Tatsuya Furukawa, Masanori Teshima, Maki Kanzawa, Mitsuyoshi Hirokawa, Naoki Otsuki, Ken-Ichi Nibu
Carcinoma arising in lingual thyroid is an extremely rare entity accounting for only 1% of all reported ectopic thyroids. Here, we report a case of carcinoma arising in lingual thyroid, which has been successfully managed by transoral resection and bilateral neck dissections. A lingual mass 4-cm in diameter with calcification was incidentally detected by computed tomography at medical check-up. No thyroid tissue was observed in normal position. Ultrasound examination showed bilateral multiple lymphadenopathies...
May 15, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29775008/-skull-base-metastasis-from-differentiated-thyroid-carcinoma-3-cases-report-and-review-of-literature
#17
Z Chen, Q H Qiu, Q H Zhang, Z C Zhu, Y Peng, H Liu
Skull base metastasis from differentiated thyroid carcinoma (DTC), including papillary and follicular thyroid carcinoma, is a rare manifestation and easily misdiagnosed. In this study, we reported three cases whose initial clinical presentation was skull base metastasis complaints with the presence of silent primary sites. Based on the thyroid ultrasound and histopathology (identifying skull base and primary thyroid tumor), the final diagnoses of DTC metastasis to skull base were confirmed. Two patients underwent removal of metastasizing tumors in the skull base and primary thyroid cancer, and have respectively survived 58 months and 4 months since then...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29774315/retrospective-analysis-of-patients-with-synchronous-primary-breast-and-thyroid-carcinoma
#18
İlker Murat Arer, Hakan Yabanoğlu, Murat Kuş, Aydıncan Akdur, Tevfik Avcı
Objective: Breast and thyroid cancers are commonly encountered malignancies. Increased risk of breast cancer in follow-up period of thyroid cancer or vice versa has been reported. However, they have some associations, synchronous presentation of these tumors is rare. We presented 12 patients diagnosed as breast and thyroid cancer and treated at the same time. Materials and Methods: Mastectomy and thyroidectomy were performed in 19 patients at the same time. 7 patients were excluded because of benign thyroid pathology...
April 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29770933/risk-factors-for-central-neck-lymph-node-metastases-in-follicular-variant-vs-classic-papillary-thyroid-carcinoma
#19
Marco Raffaelli, Carmela De Crea, Luca Sessa, Guido Fadda, Celestino Pio Lombardi, Rocco Bellantone
PURPOSE: Histological variants of papillary thyroid carcinoma (PTC) have been advocated as possible risk factors for central neck nodal metastases (CNM). A lower incidence of CNM in follicular variant of papillary thyroid carcinoma (fvPTC) when compared with classic PTC (cPTC) has been observed. We aimed to compare risk factors for CNM in patients with fvPTC and cPTC. METHODS: The medical records of 1737 patients with a diagnosis of cPTC or fvPTC were reviewed. Demographic, clinical and pathological findings were prospectively registered...
May 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29770856/risk-factors-associated-with-intrathyroid-extension-of-thyroid-microcarcinomas
#20
Nikola Slijepcevic, Vladan Zivaljevic, Aleksandar Diklic, Milan Jovanovic, Branislav Oluic, Ivan Paunovic
PURPOSE: The aims of this study were to investigate the rate of intrathyroid extension of papillary thyroid microcarcinoma (PTMC) in patients operated for benign thyroid disease and to identify independent risk factors associated with it. METHODS: A retrospective study of 301 patients operated for benign thyroid diseases (hyperthyroid diseases, multinodular goitre, Hashimoto thyroiditis and benign thyroid tumours) was performed at a high-volume endocrine surgery unit of a tertiary referral academic hospital, in a 5-year period...
May 17, 2018: Langenbeck's Archives of Surgery
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