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https://www.readbyqxmd.com/read/29351089/aggressive-variants-of-papillary-thyroid-carcinoma-hobnail-tall-cell-columnar-and-solid
#1
Meryl C Nath, Lori A Erickson
Papillary thyroid carcinomas are the most common endocrine cancer and are usually associated with good survival. However, some variants of papillary thyroid carcinomas may behave more aggressively than classic papillary thyroid carcinomas. The tall cell variant of papillary thyroid carcinoma is the most common aggressive variant of papillary thyroid carcinoma. The aggressive behavior has been ascribed to the histologic subtype and/or to the clinicopathologic features, an issue that remains controversial. The columnar variant of papillary thyroid carcinoma can be aggressive, particularly in older patients, with larger tumors showing a diffusely infiltrative growth pattern and extrathyroidal extension...
January 18, 2018: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/29349484/overall-survival-of-papillary-thyroid-carcinoma-patients-a-single-institution-long-term-follow-up-of-5897-patients
#2
Yasuhiro Ito, Akira Miyauchi, Minoru Kihara, Mitsuhiro Fukushima, Takuya Higashiyama, Akihiro Miya
INTRODUCTION: Papillary thyroid carcinoma (PTC) generally shows an excellent prognosis except in cases with aggressive backgrounds or clinicopathological features. Although the cause-specific survival (CSS) of PTC patients has been extensively investigated, the overall survival (OS) of these patients is unclear. We herein investigated both the OS and CSS of a large PTC patient series. MATERIALS AND METHODS: We enrolled 5897 PTC patients who underwent initial surgery between 1987 and 2005 (658 males and 5339 females; median age 51 years)...
January 18, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29345728/analytical-performance-of-the-thyroseq-v3-genomic-classifier-for-cancer-diagnosis-in-thyroid-nodules
#3
Marina N Nikiforova, Stephanie Mercurio, Abigail I Wald, Michelle Barbi de Moura, Keith Callenberg, Lucas Santana-Santos, William E Gooding, Linwah Yip, Robert L Ferris, Yuri E Nikiforov
BACKGROUND: Molecular tests have clinical utility for thyroid nodules with indeterminate fine-needle aspiration (FNA) cytology, although their performance requires further improvement. This study evaluated the analytical performance of the newly created ThyroSeq v3 test. METHODS: ThyroSeq v3 is a DNA- and RNA-based next-generation sequencing assay that analyzes 112 genes for a variety of genetic alterations, including point mutations, insertions/deletions, gene fusions, copy number alterations, and abnormal gene expression, and it uses a genomic classifier (GC) to separate malignant lesions from benign lesions...
January 18, 2018: Cancer
https://www.readbyqxmd.com/read/29344271/clinical-pathological-characteristics-and-prognostic-factors-for-papillary-thyroid-microcarcinoma-in-the-elderly
#4
Jing Tang, Hans B Liu, Lujiao Yu, Xin Meng, Sean X Leng, Haiyan Zhang
Background: The incidence of papillary thyroid microcarcinoma (PTMC) has increased dramatically over the past three decades worldwide. The annual rate of increase in the elderly (≥65) PTMC patients is 1.4 times higher than that in the adult (<65) PTMC patients. The aim of the present study is to identify the clinical-pathological characteristics and prognostic factors in the elderly PTMC patients. Methods: The source population is PTMC patients whose information is available in the Surveillance, Epidemiology and End Results (SEER) database (2004-2013)...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29344210/microrna-335-is-downregulated-in-papillary-thyroid-cancer-and-suppresses-cancer-cell-growth-migration-and-invasion-by-directly-targeting-zeb2
#5
Quan'e Kan, Yong Su, Huihui Yang
MicroRNAs (miRs) are a group of short, endogenous, non-protein-coding and single-stranded RNAs that regulate gene expression by binding to the 3'-untranslated region (3'UTR) of mRNAs, which results in their degradation or translational repression. The aim of the present study was to investigate the expression and function of miR-335 in human papillary thyroid cancer (PTC). Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was performed to quantify the relative miR-335 expression levels in PTC tissues and cell lines...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343651/determining-patient-selection-tool-and-response-predictor-for-outpatient-30-mci-radioiodine-ablation-dose-in-non-metastatic-differentiated-thyroid-carcinoma-a-japanese-perspective
#6
Tetsuya Higuchi, Arifudin Achmad, Duong Duc Binh, Anu Bhattarai, Yoshito Tsushima
The lack of isolation ward throughout Japan has long been limiting the 131I radioactive iodine (RAI) ablation for differentiated thyroid cancer (DTC) cases. The 30 mCi RAI ablation was only recently permitted for outpatient basis. However, no patient selection tool nor response predictor has been proposed. This study evaluated factors to find response predictor and determinant for the suitable patients. The retrospective study reviewed 47 eligible non-metastatic papillary DTC patients whose had first 30 mCi RAI ablation after total thyroidectomy...
January 16, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29343212/clinical-characteristics-of-subtypes-of-follicular-variant-papillary-thyroid-carcinoma
#7
Min Joo Kim, Jae-Kyung Won, Kyeong Cheon Jung, Ji-Hoon Kim, Sun Wook Cho, Do Joon Park, Young Joo Park
Background Among follicular variant papillary thyroid carcinomas (FVPTCs), the non-invasive encapsulated subtype has an excellent prognosis. For this reason, re-classification of non-invasive encapsulated FVPTC (EFVPTC) as a new entity called "non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)" has been proposed, but controversy remains. To characterize non-invasive EFVPTC in an Asian population, we compared the clinicopathological features of each FVPTC subtype in a Korean population...
January 17, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29342254/distinctive-desmoplastic-3d-morphology-associated-with-brafv600e-in-papillary-thyroid-cancers
#8
M Tarabichi, A Antoniou, S Le Pennec, D Gacquer, N de Saint Aubain, L Craciun, T Cielen, I Laios, D Larsimont, G Andry, J E Dumont, C Maenhaut, V Detours
Context: Although 60% of papillary thyroid carcinomas are BRAFV600E mutant (PTCV600E), the higher aggressiveness of these cancers is still debated. Objective: In PTCV600E we aimed to further characterize the extent of the stroma and its activation, the 3D tumor-stroma interface, and the proliferation rates of tumor and stromal fibroblasts. Design: We analyzed exomes, trancriptomes and images of 364 PTC from The Cancer Genome Atlas (TCGA), including 211 PTCV600E; stained 22 independent PTC for BRAFV600E and Ki67; sequenced the exomes and stained BRAFV600E in 5 primary tumor blocks and 4 nodal metastases from one PTCV600E patient; and reconstructed the 3D volumes of one tumor and one metastatic blocks at histological resolution...
January 12, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29341469/downregulation-of-csn6-attenuates-papillary-thyroid-carcinoma-progression-by-reducing-wnt-%C3%AE-catenin-signaling-and-sensitizes-cancer-cells-to-fh535-therapy
#9
Duo Wen, Tian Liao, Ben Ma, Ning Qu, Rong-Liang Shi, Zhong-Wu Lu, Yu-Long Wang, Wen-Jun Wei, Qing-Hai Ji
The incidence of thyroid cancer has increased worldwide at a rate higher than that of any other cancer. CSN6 is overexpressed in many types of cancers, and such expression is linked to oncogenic activity. However, the detailed biological functions of CSN6 in papillary thyroid cancer (PTC) have not been well characterized. We investigated CSN6 expression in PTC specimens and cell lines. We used short-hairpin RNA-mediated gene silencing to explore the biological effects of CSN6 depletion in PTC cells. The combined effects of CSN6 silencing and FH535 therapy were assessed in terms of cell viability...
January 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29340905/expression-of-vhl-tumor-suppressor-mrna-and-mir-92a-in-papillary-thyroid-carcinoma-and-their-correlation-with-clinical-and-pathological-parameters
#10
Lidija Todorović, Boban Stanojević, Vesna Mandušić, Nina Petrović, Vladan Živaljević, Ivan Paunović, Aleksandar Diklić, Vladimir Saenko, Shunichi Yamashita
A growing body of evidence suggests a role of the von Hippel-Lindau (VHL) tumor suppressor gene in the progression of papillary thyroid carcinoma (PTC). Our previous study of VHL in PTCs showed that lower VHL expression was associated with aggressive tumor features, but we found no evidence for VHL downregulation through common genetic or epigenetic modifications. Several studies pointed to a role of microRNA-92a (miR-92a) in the regulation of VHL expression in different cancers. In the present study, we examined the expression levels of VHL mRNA and miR-92a in 42 pairs of PTCs and matched non-tumor thyroid tissues by means of quantitative RT-PCR...
January 16, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29340156/hepatotoxicity-in-hyperthyroid-patient-after-consecutive-methimazole-and-propylthiouracil-therapies
#11
Fernando Gomez-Peralta, Pablo Velasco-Martínez, Cristina Abreu, María Cepeda, Marta Fernández-Puente
Methimazole (MMI) and propylthiouracil (PTU) are widely used antithyroid drugs (ATD) that have been approved for the treatment of hyperthyroidism. Hepatotoxicity may be induced by these drugs, though they exert dissimilar incidence rates of hepatotoxicity and, possibly, with different underlying pathogenic mechanisms. We report the case of a 55-year-old woman with no relevant medical history diagnosed with hyperthyroidism due to Graves' disease, who developed two episodes of acute hepatitis concurrent with the consecutive administration of two different ATDs, first MMI and then PTU...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29339640/application-of-immunocytochemistry-on-cell-block-sections-for-the-investigation-of-thyroid-lesions
#12
Niki Margari, Ilias Giovannopoulos, Abraham Pouliakis, Emmanouil Mastorakis, Alina Roxani Gouloumi, Ioannis G Panayiotides, Petros Karakitsos
OBJECTIVE: To investigate the potential of Classification and Regression Trees (CARTs) for the diagnosis of thyroid lesions based on cell block immunocytochemistry and cytological outcome. STUDY DESIGN: A total of 956 histologically confirmed cases (673 benign and 283 malignant) from patients with thyroid nodules were prepared via liquid-based cytology and evaluated; 4 additional slides were stained for cytokeratin 19 (CK-19), galectin 3 (Gal-3), Hector Battifora mesothelial cell 1 (HBME-1), and thyroglobulin...
January 16, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29339178/the-evolving-diagnosis-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp
#13
EDITORIAL
Ricardo V Lloyd, Sylvia L Asa, Virginia A LiVolsi, Peter M Sadow, Arthur S Tischler, Ronald A Ghossein, R Michael Tuttle, Yuri E Nikiforov
No abstract text is available yet for this article.
January 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29338082/racial-ethnic-differences-in-thyroid-cancer-incidence-in-the-united-states-2007-2014
#14
Kristin S Weeks, Amanda R Kahl, Charles F Lynch, Mary E Charlton
BACKGROUND: Small tumor diagnostic tools including ultrasound-guided fine needle aspiration (FNA) and computed tomography (CT) could be causing rising and racially/ethnically different thyroid cancer incidence rates due to variable overdiagnosis of indolent tumors. Papillary tumors and <40 mm tumors are most likely to be overdiagnosed as indolent tumors by FNA and CT. METHODS: Age-adjusted incidence rates (AAIRs) for the years 2007-2014 were calculated for race/ethnicity (white, Hispanic, Asian, African American, Native American) by patient/tumor characteristics for microscopically confirmed malignant thyroid cancer cases in the Surveillance, Epidemiology, and End Results Program 18 database (SEER 18; N = 93,607)...
January 16, 2018: Cancer
https://www.readbyqxmd.com/read/29337176/comparison-of-the-diagnostic-performances-of-ultrasonography-ct-and-fine-needle-aspiration-cytology-for-the-prediction-of-lymph-node-metastasis-in-patients-with-lymph-node-dissection-of-papillary-thyroid-carcinoma-a-retrospective-cohort-study
#15
Na Lae Eun, Eun Ju Son, Jeong-Ah Kim, Hye Mi Gweon, Jung-Hyun Kang, Ji Hyun Youk
PURPOSE: To evaluate the diagnostic performances of ultrasonographic (US) findings, computed tomography (CT) findings and fine needle aspiration cytology (FNAC) for the prediction of cervical lymph node (LN) metastases of papillary thyroid carcinoma (PTC) to determine which LN should be dissected. METHODS: 376 LNs in 302 patients who underwent both US-guided skin surface LN markings and CT before LN dissection were analyzed retrospectively. Indications for LN dissection were suspicious US findings of LN metastases (n = 300), suspicious CT findings (n = 67) or surgeon's request (n = 9)...
January 11, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29336760/cancer-frequency-in-retrosternal-goiter
#16
Nuri A Sahbaz, Firat Tutal, Nihat Aksakal, Sami Acar, Kadir I Aksu, Umut Barbaros, Yesim Erbil
Retrosternal goiter prevalence is 5 to 40 per cent according to classifications in goiter series. Goiters with mediastinal extension were reported to be related with higher cancer rates. In our study, we aimed to investigate whether cancer incidence increased in retrosternal goiters compared with the cervical ones. Three hundred and ninety consecutive patients, who had surgery because of retrosternal goiter in Istanbul University Medical Faculty Department of General Surgery between 2005 and 2015 were included in the study (Group 1)...
December 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29331886/anti-cancer-effects-of-hnha-and-lenvatinib-by-the-suppression-of-emt-mediated-drug-resistance-in-cancer-stem-cells
#17
Yong Sang Lee, Seok-Mo Kim, Bup-Woo Kim, Ho Jin Chang, Soo Young Kim, Cheong Soo Park, Ki Cheong Park, Hang-Seok Chang
Anaplastic thyroid cancer (ATC) constitutes less than 2% of total thyroid cancers but accounts for 20-40% of thyroid cancer-related deaths. Cancer stem cell drug resistance represents a primary factor hindering treatment. This study aimed to develop targeted agents against thyroid malignancy, focusing on individual and synergistic effects of HNHA (histone deacetylase), lenvatinib (FGFR), and sorafenib (tyrosine kinase) inhibitors. Patients with biochemically and histologically proven papillary thyroid cancer (PTC) and ATC were included...
January 11, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29331885/autonomously-hyperfunctioning-cystic-nodule-harbouring-thyroid-carcinoma-case-report-and-literature-review
#18
Maria João Lima, Virgínia Soares, Pedro Koch, Artur Silva, António Taveira-Gomes
INTRODUCTION: Hyperthyroidism is rarely associated with malignancy, but it cannot rule out thyroid cancer. Although there is published data describing this coexistence, thyroid carcinomas inside autonomously functioning nodules are uncommon. PRESENTATION OF CASE: A 49-year-old woman presented with a cervical mass, unexplained weight loss and anxiousness, sweating and insomnia. On physical examination, she had a palpable left thyroid nodule. Thyroid function tests showed suppressed TSH (<0,1 uUI/mL), thyroxine 1,44 ng/dL (normal range 0,70-1,48) and triiodothyronine 4,33 pg/mL (normal range 1,71-3,71)...
January 8, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29329789/lateral-lymph-node-metastasis-in-papillary-thyroid-carcinoma-a-systematic-review-and-meta-analysis-for-prevalence-risk-factors-and-location
#19
REVIEW
Yoon Kyoung So, Min-Ji Kim, Seonwoo Kim, Young-Ik Son
BACKGROUND: Lymph node metastasis (LNM) is frequent in papillary thyroid carcinoma (PTC) and is associated with a poor prognosis. Unlike central LNM (CLNM), there are few studies focusing on LLNM. We aimed to investigate the prevalence and the risk factors for LLNM, with its most prevalent sites. METHODS: We performed a comprehensive literature search using the PubMed and EMBASE databases for relevant studies published prior to November 2016 that examined the risk factors for LLNM...
January 9, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29328463/construction-and-investigation-of-lncrna-associated-cerna-regulatory-network-in-papillary-thyroid-cancer
#20
Yangjing Zhao, Hui Wang, Chengjiang Wu, Meina Yan, Haojie Wu, Jingzhe Wang, Xinxin Yang, Qixiang Shao
Increasing evidence has experimentally proved the competitive endogenous RNA (ceRNA) hypothesis that long non-coding RNA (lncRNA) can affect the expression of RNA targets by competitively combining microRNA (miRNA) via miRNA response elements. However, an extensive ceRNA network of thyroid carcinoma in a large cohort has not been evaluated. We analyzed the RNAseq and miRNAseq data of 348 cases of primary papillary thyroid cancer (PTC) patients with clinical information downloaded from The Cancer Genome Atlas (TCGA) project to search for potential biomarkers or therapeutic targets...
January 10, 2018: Oncology Reports
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