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JOURNAL ARTICLE
Parnia Geransar, Simon Lal, Palle B Jeppesen, Loris Pironi, Ewelina Rzepa, Stéphane M Schneider
BACKGROUND AND AIM: Chronic intestinal failure (IF) is a rare but life-altering condition, care delivery of which is complex. The ATLAS Programme was initiated in 2016 to increase disease awareness and address inconsistencies in delivery of care across Europe. We describe the results of a non-interventional study that aimed to explore how adult patients with chronic IF are managed across Europe. MATERIALS AND METHODS: This mixed-methods, non-interventional, cross-sectional study comprised a desk-based landscape assessment (Phase 1), qualitative interviews (Phase 2), and an online quantitative survey (Phase 3) completed by healthcare professionals (HCPs) involved in the management of adult patients with chronic IF during the period November 2020 to January 2021...
April 2023: Clinical Nutrition ESPEN
#22
JOURNAL ARTICLE
Chirag Kulkarni, Shivani Sharma, Konica Porwal, Swati Rajput, Sreyanko Sadhukhan, Vaishnavi Singh, Akanksha Singh, Sanjana Baranwal, Saroj Kumar, Aboli Girme, Alka Raj Pandey, Suriya Pratap Singh, Koneni V Sashidhara, Navin Kumar, Lal Hingorani, Naibedya Chattopadhyay
INTRODUCTION: In obese humans, Coleus forskohlii root extract (CF) protects against weight gain owing to the presence of forskolin, an adenylate cyclase (AC) activator. As AC increases intracellular cyclic adenosine monophosphate (cAMP) levels in osteoblasts that has an osteogenic effect, we thus tested the skeletal effects of a standardized CF (CFE) in rats. METHODS: Concentrations of forskolin and isoforskolin were measured in CFE by HPLC. CFE and forskolin (the most abundant compound present in CFE) were studied for their osteogenic efficacy in vitro by alkaline phosphatase (ALP), cAMP and cyclic guanosine monophosphate (cGMP) assays...
2023: Frontiers in Endocrinology
#23
JOURNAL ARTICLE
Anne Marie Sowerbutts, Simon Lal, Loris Pironi, Debra Jones, Chloe French, Marianne Riis, Andrew Clamp, Jennifer McCracken, Leanne Williamson, Carolyn Wheatley, Bethany Johnson, Sorrel Burden
BACKGROUND & AIMS: Home parenteral nutrition (HPN) is the primary treatment for chronic intestinal failure (CIF) due to non-malignant disease and is increasingly used in patients with a diagnosis of cancer. This project engaged with patients, family members and healthcare professionals to ascertain what questions they want researched. METHODS: This study followed the five-stage process of the James Lind Alliance that involved (1) setting up a steering group, (2) carrying out an initial survey to gather participants' questions, (3) data processing, (4) an interim priority setting survey and (5) final priority setting workshop...
February 2023: Clinical Nutrition ESPEN
#24
JOURNAL ARTICLE
Emily Haeuser, Audrey L Serfes, Michael A Cork, Mingyou Yang, Hedayat Abbastabar, E S Abhilash, Maryam Adabi, Oladimeji M Adebayo, Victor Adekanmbi, Daniel Adedayo Adeyinka, Saira Afzal, Bright Opoku Ahinkorah, Keivan Ahmadi, Muktar Beshir Ahmed, Yonas Akalu, Rufus Olusola Akinyemi, Chisom Joyqueenet Akunna, Fares Alahdab, Fahad Mashhour Alanezi, Turki M Alanzi, Kefyalew Addis Alene, Robert Kaba Alhassan, Vahid Alipour, Amir Almasi-Hashiani, Nelson Alvis-Guzman, Edward Kwabena Ameyaw, Saeed Amini, Dickson A Amugsi, Robert Ancuceanu, Davood Anvari, Seth Christopher Yaw Appiah, Jalal Arabloo, Olatunde Aremu, Mulusew A Asemahagn, Mohammad Asghari Jafarabadi, Atalel Fentahun Awedew, Beatriz Paulina Ayala Quintanilla, Martin Amogre Ayanore, Yared Asmare Aynalem, Samad Azari, Zelalem Nigussie Azene, B B Darshan, Tesleem Kayode Babalola, Atif Amin Baig, Maciej Banach, Till Winfried Bärnighausen, Arielle Wilder Bell, Akshaya Srikanth Bhagavathula, Nikha Bhardwaj, Pankaj Bhardwaj, Krittika Bhattacharyya, Ali Bijani, Zebenay Workneh Bitew, Somayeh Bohlouli, Obasanjo Afolabi Bolarinwa, Archith Boloor, Ivana Bozicevic, Zahid A Butt, Rosario Cárdenas, Felix Carvalho, Jaykaran Charan, Vijay Kumar Chattu, Mohiuddin Ahsanul Kabir Chowdhury, Dinh-Toi Chu, Richard G Cowden, Saad M A Dahlawi, Giovanni Damiani, Eugene Kofuor Maafo Darteh, Aso Mohammad Darwesh, José das Neves, Nicole Davis Weaver, Diego De Leo, Jan-Walter De Neve, Kebede Deribe, Keshab Deuba, Samath Dharmaratne, Mostafa Dianatinasab, Daniel Diaz, Alireza Didarloo, Shirin Djalalinia, Fariba Dorostkar, Eleonora Dubljanin, Bereket Duko, Maha El Tantawi, Shaimaa I El-Jaafary, Babak Eshrati, Sharareh Eskandarieh, Oghenowede Eyawo, Ifeanyi Jude Ezeonwumelu, Sayeh Ezzikouri, Farshad Farzadfar, Nazir Fattahi, Nelsensius Klau Fauk, Eduarda Fernandes, Irina Filip, Florian Fischer, Nataliya A Foigt, Masoud Foroutan, Takeshi Fukumoto, Mohamed M Gad, Abhay Motiramji Gaidhane, Birhan Gebresillassie Gebregiorgis, Ketema Bizuwork Gebremedhin, Lemma Getacher, Keyghobad Ghadiri, Ahmad Ghashghaee, Mahaveer Golechha, Mohammed Ibrahim Mohialdeen Gubari, Harish Chander Gugnani, Rafael Alves Guimarães, Mohammad Rifat Haider, Arvin Haj-Mirzaian, Samer Hamidi, Abdiwahab Hashi, Soheil Hassanipour, Hadi Hassankhani, Khezar Hayat, Claudiu Herteliu, Hung Chak Ho, Ramesh Holla, Mostafa Hosseini, Mehdi Hosseinzadeh, Bing-Fang Hwang, Segun Emmanuel Ibitoye, Olayinka Stephen Ilesanmi, Irena M Ilic, Milena D Ilic, Rakibul M Islam, Chidozie C D Iwu, Mihajlo Jakovljevic, Ravi Prakash Jha, John S Ji, Kimberly B Johnson, Nitin Joseph, Vasna Joshua, Farahnaz Joukar, Jacek Jerzy Jozwiak, Leila R Kalankesh, Rohollah Kalhor, Naser Kamyari, Tanuj Kanchan, Behzad Karami Matin, Salah Eddin Karimi, Gbenga A Kayode, Ali Kazemi Karyani, Maryam Keramati, Ejaz Ahmad Khan, Gulfaraz Khan, Md Nuruzzaman Khan, Khaled Khatab, Jagdish Khubchandani, Yun Jin Kim, Adnan Kisa, Sezer Kisa, Jacek A Kopec, Soewarta Kosen, Sindhura Lakshmi Koulmane Laxminarayana, Ai Koyanagi, Kewal Krishan, Barthelemy Kuate Defo, Nuworza Kugbey, Vaman Kulkarni, Manasi Kumar, Nithin Kumar, Dian Kusuma, Carlo La Vecchia, Dharmesh Kumar Lal, Iván Landires, Heidi Jane Larson, Savita Lasrado, Paul H Lee, Shanshan Li, Xuefeng Liu, Afshin Maleki, Preeti Malik, Mohammad Ali Mansournia, Francisco Rogerlândio Martins-Melo, Walter Mendoza, Ritesh G Menezes, Endalkachew Worku Mengesha, Tuomo J Meretoja, Tomislav Mestrovic, Andreea Mirica, Babak Moazen, Osama Mohamad, Yousef Mohammad, Abdollah Mohammadian-Hafshejani, Reza Mohammadpourhodki, Salahuddin Mohammed, Shafiu Mohammed, Ali H Mokdad, Masoud Moradi, Paula Moraga, Sumaira Mubarik, Getaneh Baye B Mulu, Lillian Mwanri, Ahamarshan Jayaraman Nagarajan, Mukhammad David Naimzada, Muhammad Naveed, Javad Nazari, Rawlance Ndejjo, Ionut Negoi, Frida N Ngalesoni, Georges Nguefack-Tsague, Josephine W Ngunjiri, Cuong Tat Nguyen, Huong Lan Thi Nguyen, Chukwudi A Nnaji, Jean Jacques Noubiap, Virginia Nuñez-Samudio, Vincent Ebuka Nwatah, Bogdan Oancea, Oluwakemi Ololade Odukoya, Andrew T Olagunju, Babayemi Oluwaseun Olakunde, Bolajoko Olubukunola Olusanya, Jacob Olusegun Olusanya, Ahmed Omar Bali, Obinna E Onwujekwe, Orish Ebere Orisakwe, Nikita Otstavnov, Stanislav S Otstavnov, Mayowa O Owolabi, P A Mahesh, Jagadish Rao Padubidri, Adrian Pana, Ashok Pandey, Seithikurippu R Pandi-Perumal, Fatemeh Pashazadeh Kan, George C Patton, Shrikant Pawar, Emmanuel K Peprah, Maarten J Postma, Liliana Preotescu, Zahiruddin Quazi Syed, Navid Rabiee, Amir Radfar, Alireza Rafiei, Fakher Rahim, Vafa Rahimi-Movaghar, Amir Masoud Rahmani, Kiana Ramezanzadeh, Juwel Rana, Chhabi Lal Ranabhat, Sowmya J Rao, David Laith Rawaf, Salman Rawaf, Reza Rawassizadeh, Lemma Demissie Regassa, Nima Rezaei, Aziz Rezapour, Mavra A Riaz, Ana Isabel Ribeiro, Jennifer M Ross, Enrico Rubagotti, Susan Fred Rumisha, Godfrey M Rwegerera, Sahar Saeedi Moghaddam, Rajesh Sagar, Biniyam Sahiledengle, Maitreyi Sahu, Marwa Rashad Salem, Hossein Samadi Kafil, Abdallah M Samy, Benn Sartorius, Brijesh Sathian, Abdul-Aziz Seidu, Amira A Shaheen, Masood Ali Shaikh, Morteza Shamsizadeh, Wondimeneh Shibabaw Shiferaw, Jae Il Shin, Roman Shrestha, Jasvinder A Singh, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Shahin Soltani, Mu'awiyyah Babale Sufiyan, Takahiro Tabuchi, Eyayou Girma Tadesse, Nuno Taveira, Fisaha Haile Tesfay, Rekha Thapar, Marcos Roberto Tovani-Palone, Gebiyaw Wudie Tsegaye, Chukwuma David Umeokonkwo, Bhaskaran Unnikrishnan, Jorge Hugo Villafañe, Francesco S Violante, Bay Vo, Giang Thu Vu, Yohannes Dibaba Wado, Yasir Waheed, Richard G Wamai, Yanzhong Wang, Paul Ward, Nuwan Darshana Wickramasinghe, Katherine Wilson, Sanni Yaya, Paul Yip, Naohiro Yonemoto, Chuanhua Yu, Mikhail Sergeevich Zastrozhin, Yunquan Zhang, Zhi-Jiang Zhang, Simon I Hay, Laura Dwyer-Lindgren
BACKGROUND: Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is still among the leading causes of disease burden and mortality in sub-Saharan Africa (SSA), and the world is not on track to meet targets set for ending the epidemic by the Joint United Nations Programme on HIV/AIDS (UNAIDS) and the United Nations Sustainable Development Goals (SDGs). Precise HIV burden information is critical for effective geographic and epidemiological targeting of prevention and treatment interventions...
December 19, 2022: BMC Medicine
#25
Meghan Brown, Nika Z Garbajs, Simon Zec, Hisham Mushtaq, Anwar Khedr, Abbas B Jama, Ibtisam Rauf, Mikael Mir, Aishwarya R Korsapati, Shikha Jain, Thoyaja Koritala, Ramesh Adhikari, Amos Lal, Ognjen Gajic, Juan Pablo Domecq, Sarah Goksoy, Brian Bartlett, Amit Sharma, Nitesh Kumar Jain, Syed Anjum Khan
Multisystem inflammatory syndrome is a life-threatening condition associated with elevated inflammatory markers and multiple organ injury. A diagnosis of exclusion, it has been reported after severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2) in children and adults; recently it has been described in some post-COVID-19 vaccinated individuals. The prognosis with supportive care and immunomodulatory therapy is good, although some individuals may require treatment in the intensive care unit (ICU)...
2022: Journal of Community Hospital Internal Medicine Perspectives
#26
REVIEW
Shalini Lal, Stephanie Tremblay, Danielle Starcevic, Melina Mauger-Lavigne, Dana Anaby
Aim: This scoping review aims to better understand the extent and nature of research activity on the topic of mental health problems in young people with childhood-onset physical disabilities. Specifically, we document what has been investigated in terms of the occurrence and experience of mental health problems among young people with childhood-onset physical disabilities, and their access to mental health services. Methods: We searched four databases (Medline, PsycINFO, CINAHL, Embase) for articles published between 2007 and 2019...
2022: Front Rehabil Sci
#27
RANDOMIZED CONTROLLED TRIAL
Steven J Russell, Roy W Beck, Edward R Damiano, Firas H El-Khatib, Katrina J Ruedy, Courtney A Balliro, Zoey Li, Peter Calhoun, R Paul Wadwa, Bruce Buckingham, Keren Zhou, Mark Daniels, Philip Raskin, Perrin C White, Jane Lynch, Jeremy Pettus, Irl B Hirsch, Robin Goland, John B Buse, Davida Kruger, Nelly Mauras, Andrew Muir, Janet B McGill, Fran Cogen, Jill Weissberg-Benchell, Jordan S Sherwood, Luz E Castellanos, Mallory A Hillard, Marwa Tuffaha, Melissa S Putman, Mollie Y Sands, Gregory Forlenza, Robert Slover, Laurel H Messer, Erin Cobry, Viral N Shah, Sarit Polsky, Rayhan Lal, Laya Ekhlaspour, Michael S Hughes, Marina Basina, Betul Hatipoglu, Leann Olansky, Amrit Bhangoo, Nikta Forghani, Himala Kashmiri, Francoise Sutton, Abha Choudhary, Jimmy Penn, Rabab Jafri, Maria Rayas, Elia Escaname, Catherine Kerr, Ruby Favela-Prezas, Schafer Boeder, Subbulaxmi Trikudanathan, Kristen M Williams, Natasha Leibel, M Sue Kirkman, Kate Bergamo, Klara R Klein, Jean M Dostou, Sriram Machineni, Laura A Young, Jamie C Diner, Arti Bhan, J Kimberly Jones, Matthew Benson, Keisha Bird, Kimberly Englert, Joe Permuy, Kristina Cossen, Eric Felner, Maamoun Salam, Julie M Silverstein, Samantha Adamson, Andrea Cedeno, Seema Meighan, Andrew Dauber
BACKGROUND: Currently available semiautomated insulin-delivery systems require individualized insulin regimens for the initialization of therapy and meal doses based on carbohydrate counting for routine operation. In contrast, the bionic pancreas is initialized only on the basis of body weight, makes all dose decisions and delivers insulin autonomously, and uses meal announcements without carbohydrate counting. METHODS: In this 13-week, multicenter, randomized trial, we randomly assigned in a 2:1 ratio persons at least 6 years of age with type 1 diabetes either to receive bionic pancreas treatment with insulin aspart or insulin lispro or to receive standard care (defined as any insulin-delivery method with unblinded, real-time continuous glucose monitoring)...
September 29, 2022: New England Journal of Medicine
#28
JOURNAL ARTICLE
Jagadeesh Menon, Babu Ram Thapa, Rajni Kumari, Srikanth Puttaiah Kadyada, Satyavati Rana, Sadhna B Lal
OBJECTIVE: Pediatric irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder with variable response to various therapeutic agents. Psyllium has been proven to be effective in adults; however, there is no study in children. To evaluate the efficacy of psyllium husk as compared to placebo in Pediatric IBS patients. METHODS: In this double blind Randomized controlled trial, 43 children were assigned to psyllium arm (Group A) and 38 into placebo arm (Group B)...
September 22, 2022: Journal of Pediatric Gastroenterology and Nutrition
#29
REVIEW
Eleni Ioanna Katsigianni, Panagiotis Petrou
OBJECTIVE: The objective of this paper is to assess the economic profile of enzyme replacement therapy (ERT) to symptomatic patients with Pompe, Fabry, Gaucher disease and Lysosomal acid lipase (LAL) deficiency. METHODS: A systematic search was performed to retrieve and critically assess economic evaluations of enzyme replacement therapy. Publications were screened according to predefined criteria and evaluated according to the Quality of Economic Studies. Data were narratively synthesized...
September 19, 2022: Cost Effectiveness and Resource Allocation: C/E
#30
JOURNAL ARTICLE
Patricia Lam, Anna Ashbrook, Deborah A Zygmunt, Cong Yan, Hong Du, Paul T Martin
Lysosomal acid lipase deficiency (LAL-D) presents as one of two rare autosomal recessive diseases: Wolman disease (WD), a severe disorder presenting in infancy characterized by absent or very low LAL activity, and cholesteryl ester storage disease (CESD), a less severe, later onset disease form. Recent clinical studies have shown efficacy of enzyme replacement therapy for both forms of LAL-D; however, no gene therapy approach has yet been developed for clinical use. Here, we show that rscAAVrh74.miniCMV. LIPA gene therapy can significantly improve disease symptoms in the Lipa -/- mouse model of LAL-D...
September 8, 2022: Molecular Therapy. Methods & Clinical Development
#31
JOURNAL ARTICLE
Sangeeta Maurya, Amitabh Krishna, Bechan Lal, Ajit Singh
Asprosin is an orexigenic adipokine that regulates appetite and glucose homeostasis in mammals. To date, only fragmentary findings are reported regarding its role in testicular activities. In the current investigation, immunolocalization and direct action of asprosin in adult mice testis was evaluated. Immunohistochemical and immunoblot studies were performed to analyse the testicular expression of asprosin. Intratesticular treatment of asprosin (0.1 μg and 1.0 μg per testis) was given to evaluate its direct action on testicular functions...
September 3, 2022: Andrologia
#32
MULTICENTER STUDY
Kevin H M Kuo, D Mark Layton, Ashutosh Lal, Hanny Al-Samkari, Joy Bhatia, Penelope A Kosinski, Bo Tong, Megan Lynch, Katrin Uhlig, Elliott P Vichinsky
BACKGROUND: Patients with non-transfusion-dependent thalassaemia (NTDT), although they do not require regular blood transfusions for survival, can still accrue a heavy burden of comorbidities. No approved disease-modifying therapies exist for these patients. We aimed to investigate the safety and efficacy of mitapivat (Agios Pharmaceuticals, Cambridge, MA, USA), a pyruvate kinase activator, in adults with non-transfusion-dependent (NTD) α-thalassaemia or NTD β-thalassaemia...
August 13, 2022: Lancet
#33
REVIEW
Ashley Jia Wen Yip, Zheng Yao Low, Vincent T K Chow, Sunil K Lal
Molnupiravir is a β-d-N4-hydroxycytidine-5'-isopropyl ester (NHC) compound that exerts antiviral activity against various RNA viruses such as influenza, SARS, and Ebola viruses. Thus, the repurposing of Molnupiravir has gained significant attention for combatting infection with SARS-CoV-2, the etiological agent of COVID-19. Recently, Molnupiravir was granted authorization for the treatment of mild-to-moderate COVID-19 in adults. Findings from in vitro experiments, in vivo studies and clinical trials reveal that Molnupiravir is effective against SARS-CoV-2 by inducing viral RNA mutagenesis, thereby giving rise to mutated complementary RNA strands that generate non-functional viruses...
June 20, 2022: Viruses
#34
JOURNAL ARTICLE
Ramakant Dandriyal, Vishakha Lal, Kolli Yada Giri, Niranjanaprasad Indra Bavanthabettu, Archana Chaurasia, Swati Pant
Objective: The purpose of the study was to analyse the long-term results of ameloblastoma, which was treated at our centre. Study Design: We carried out a retrospective study of 10 years of clinical records from 2007 to 2016 with 102 consecutive cases of ameloblastoma. Data of all patients were collected and analysed with follow-up to 9 years. Results: The data analysis revealed male (59.8%) predominance over female (40.2%) with a mean age of 30...
June 2022: Journal of Maxillofacial and Oral Surgery
#35
JOURNAL ARTICLE
Sajad Khaliq Dar, Sudershan Kumar, Sovan Maiti, Shilpi Dhawan, Sadhna Joglekar, Upasana Arora, Rinku Kalra, Sumit Madan, Altaf A Lal, Venugopal Singamaneni, Prasoon Gupta, Utpal Nandi, Deepika Singh, Arshad H Khuroo
Background and aim: Dengue a worldwide concern for public health has no effective vaccine or drug available for its prevention or treatment. There are billions of people who are at risk of contracting the dengue virus (DENV) infections with only anti-mosquito strategies to combat this disease. Based on the reports, particularly in vitro studies and small animal studies showing anti-viral activity of aqueous extract of Cocculus hirsutus (AQCH), studies were conducted on AQCH tablets as a potential for the treatment of dengue and COVID-19 infections...
May 2022: Heliyon
#36
RANDOMIZED CONTROLLED TRIAL
Anh Duc Dang, Thiem Dinh Vu, Ha Hai Vu, Van Thanh Ta, Anh Thi Van Pham, Mai Thi Ngoc Dang, Be Van Le, Thai Huu Duong, Duoc Van Nguyen, Saranath Lawpoolsri, Pailinrut Chinwangso, Jason S McLellan, Ching-Lin Hsieh, Adolfo Garcia-Sastre, Peter Palese, Weina Sun, Jose L Martinez, Irene Gonzalez-Dominguez, Stefan Slamanig, Juan Manuel Carreño, Johnstone Tcheou, Florian Krammer, Ariel Raskin, Huong Minh Vu, Thang Cong Tran, Huong Mai Nguyen, Laina D Mercer, Rama Raghunandan, Manjari Lal, Jessica A White, Richard Hjorth, Bruce L Innis, Rami Scharf
Production of affordable coronavirus disease 2019 (COVID-19) vaccines in low- and middle-income countries is needed. NDV-HXP-S is an inactivated egg-based Newcastle disease virus (NDV) vaccine expressing the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Wuhan-Hu-1. The spike protein was stabilized and incorporated into NDV virions by removing the polybasic furin cleavage site, introducing the transmembrane domain and cytoplasmic tail of the fusion protein of NDV, and introducing six prolines for stabilization in the prefusion state...
June 9, 2022: Vaccine
#37
Manuela Ferrari, Judith Sabetti, Sarah V McIlwaine, Sahar Fazeli, S M Hani Sadati, Jai L Shah, Suzanne Archie, Katherine M Boydell, Shalini Lal, Joanna Henderson, Mario Alvarez-Jimenez, Neil Andersson, Rune Kristian Lundedal Nielsen, Jennifer A Reynolds, Srividya N Iyer
Nearly all young people use the internet daily. Many youth with mental health concerns, especially since the Covid-19 pandemic, are using this route to seek help, whether through digital mental health treatment, illness prevention tools, or supports for mental wellbeing. Videogames also have wide appeal among young people, including those who receive mental health services. This review identifies the literature on videogame interventions for young people, ages 12-29, and maps the data on game use by those with mental health and substance use problems, focusing on evidence for the capacity of games to support treatment in youth mental health services; how stakeholders are involved in developing or evaluating games; and any potential harms and ethical remedies identified...
2022: Frontiers in digital health
#38
JOURNAL ARTICLE
Barbara K Burton, Alejandra Consuelo Sanchez, Maria Kostyleva, Ana Maria Martins, Sachin Marulkar, Florian Abel, Ivo Barić
OBJECTIVES: Sebelipase alfa is approved for treatment of lysosomal acid lipase deficiency (LAL-D). This single-arm, open-label study (NCT02112994) evaluated sebelipase alfa efficacy and safety in patients with LAL-D. METHODS: Patients >8 months of age diagnosed with LAL-D received sebelipase alfa 1.0 mg/kg by intravenous infusion every other week (qow) for up to 144 weeks. Dose escalation to 3.0 mg/kg qow and subsequently to 3.0 mg/kg weekly was permitted, per protocol; dose reductions for tolerability were permitted to 0...
April 20, 2022: Journal of Pediatric Gastroenterology and Nutrition
#39
JOURNAL ARTICLE
Vijairam Selvaraj, Amos Lal, Arkadiy Finn, Joshua Ray Tanzer, Muhammad Baig, Atin Jindal, Kwame Dapaah-Afriyie, George Bayliss
BACKGROUND: Since the beginning of corona virus disease 2019 (COVID-19) pandemic, there has been a widespread use of remdesivir in adults and children. There is little known information about its outcomes in patients with end stage renal disease who are on dialysis. AIM: To assess the clinical outcomes with use of remdesivir in adult patients with end stage kidney failure on hemodialysis. METHODS: A retrospective, multicenter study was conducted on patients with end stage renal disease on hemodialysis that were discharged after treatment for COVID-19 between April 1, 2020 and December 31, 2020...
January 9, 2022: World Journal of Critical Care Medicine
#40
JOURNAL ARTICLE
Srinivas Govindarajulu, Thirumugam Muthuvel, Vivek Lal, Karthikeyan P Rajendran, Sudha Seshayyan
BACKGROUND: Skin lesions are the most common early symptoms of leprosy, often ignored by patients at an early stage and misdiagnosed as other dermatological diseases by healthcare personnel, leading to delay in diagnosis and treatment of leprosy precipitating permanent neurological deficit, deformities and serious disabilities. AIMS: The objective is to evaluate the duration of delay and factors responsible for the delay in reporting of patients, among the newly detected leprosy cases (Grade 1 and Grade 2 disability patients)...
March 24, 2022: Indian Journal of Dermatology, Venereology and Leprology
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