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Sepsis, ARDS, mechanical ventilation, critical ill,

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https://www.readbyqxmd.com/read/27042657/clinical-characteristics-and-30-day-outcomes-of-intermittent-hemodialysis-for-acute-kidney-injury-in-an-african-intensive-care-unit
#1
Arthur Kwizera, Janat Tumukunde, Lameck Ssemogerere, Emmanuel Ayebale, Peter Agaba, Jamali Yakubu, Aggrey Lubikire, Mary Nabukenya, Robert Kalyesubula
INTRODUCTION: Acute kidney injury (AKI) is a common occurrence in the intensive care unit (ICU). Studies have looked at outcomes of renal replacement therapy using intermittent haemodialysis (IHD) in ICUs with varying results. Little is known about the outcomes of using IHD in resource-limited settings where continuous renal replacement therapy (CRRT) is limited. We sought to determine outcomes of IHD among critically ill patients admitted to a low-income country ICU. METHODS: A retrospective review of patient records was conducted...
2016: BioMed Research International
https://www.readbyqxmd.com/read/26820274/what-is-the-evidence-for-harm-of-neuromuscular-blockade-and-corticosteroid-use-in-the-intensive-care-unit
#2
Djillali Annane
Neuromuscular blocking agents and corticosteroids are widely used in medicine and in particular in the intensive care unit (ICU). Neuromuscular blockade is commonly used to ease tracheal intubation, to optimize mechanical ventilation and oxygenation in acute respiratory disorders such as status asthmaticus and acute respiratory distress syndrome (ARDS), to prevent shivering during therapeutic hypothermia, and also in patients with elevated intracranial pressure. In the ICU, patients with sepsis, ARDS, community-acquired pneumonia, exacerbation of chronic obstructive pulmonary disease, severe asthma, or trauma may receive corticosteroids...
February 2016: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/26336861/scoring-systems-in-assessing-survival-of-critically-ill-icu-patients
#3
Ana D Sekulic, Sladjana V Trpkovic, Aleksandar P Pavlovic, Olivera M Marinkovic, Aleksandra N Ilic
BACKGROUND: The aim of this study was to determine which of the most commonly used scoring systems for evaluation of critically ill patients in the ICU is the best and simplest to use in our hospital. MATERIAL AND METHODS: This prospective study included 60 critically ill patients. After admittance to the ICU, APACHE II, SAPS II, and MPM II0 were calculated. During further treatment in the ICU, SOFA and MPM II were calculated at 24 h, 48 h, and 72 h and 7 days after admittance using laboratory and radiological measures...
2015: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/26015869/effect-of-enteral-diet-enriched-with-eicosapentaenoic-acid-gamma-linolenic-acid-and-antioxidants-in-patients-with-sepsis-induced-acute-respiratory-distress-syndrome
#4
Kunihiro Shirai, Shozo Yoshida, Naoki Matsumaru, Izumi Toyoda, Shinji Ogura
BACKGROUND: In this study, the effects of an enteral diet enriched with eicosapentaenoic acid (EPA), γ-linolenic acid (GLA), and antioxidants were compared with a standard enteral diet in critically ill patients with sepsis-induced acute respiratory distress syndrome (ARDS). METHODS: This study was a single-center, prospective, randomized, single-blind, controlled trial in our Advanced Critical Care Center. Patients were randomized to receive a continuous EPA, GLA, and antioxidant-enriched diet (study group), or an isocaloric standard diet (control group)...
2015: Journal of Intensive Care
https://www.readbyqxmd.com/read/24651234/serum-mmp-8-and-timp-1-in-critically-ill-patients-with-acute-respiratory-failure-timp-1-is-associated-with-increased-90-day-mortality
#5
Johanna Hästbacka, Rita Linko, Taina Tervahartiala, Tero Varpula, Seppo Hovilehto, Ilkka Parviainen, Suvi T Vaara, Timo Sorsa, Ville Pettilä
BACKGROUND: Matrix metalloproteinases (MMPs) likely have an important role in the pathophysiology of acute lung injury. In a recent study, high matrix metalloproteinases (MMP-8) levels in tracheal aspirates of pediatric acute respiratory distress syndrome (ARDS) patients were associated with worse outcome. In patients with sepsis, an imbalance between MMPs and their tissue inhibitors (TIMPs) has been associated with impaired survival. We hypothesized that the elevated systemic MMP-8 and TIMP-1 are associated with worse outcome in acute respiratory failure...
April 2014: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/24074819/bacterial-respiratory-tract-infections-are-promoted-by-systemic-hyperglycemia-after-severe-burn-injury-in-pediatric-patients
#6
Robert Kraft, David N Herndon, Ronald P Mlcak, Celeste C Finnerty, Robert A Cox, Felicia N Williams, Marc G Jeschke
BACKGROUND: Burns are associated with hyperglycemia leading to increased incidence of infections with pneumonia being one of the most prominent and adverse complications. Recently, various studies in critically ill patients indicated that increased pulmonary glucose levels with airway/blood glucose threshold over 150 mg/dl lead to an overwhelming growth of bacteria in the broncho-pulmonary system, subsequently resulting in an increased risk of pulmonary infections. The aim of the present study was to determine whether a similar cutoff value exists for severely burned pediatric patients...
May 2014: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/23699445/to-determine-the-predictors-of-mortality-and-morbidity-of-sepsis-in-medical-icu-of-all-india-institute-of-medical-sciences-aiims-new-delhi-india
#7
Prajowl Shrestha, Anant Mohan, Surendra Sharma, Randeep Guleria, Naval Vikram, Naveet Wig, Ravindra Pandey
SESSION TYPE: Sepsis/Shock PostersPRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PMPURPOSE: Although sepsis is one of the leading cause of mortality in hospitalized patients, information regarding early predictive factors for mortality and morbidity is limited.METHODS: Patients fulfilling the Infectious Disease Society of America criteria of sepsis within the Medical ICU were included randomly. Apart from baseline hematological, biochemical and metabolic parameters, Acute Physiology and Chronic Health Evaluation II (APACHE II), Simplified acute physiology score II and III (SAPS II and SAPS III) and Sequential organ function assessment (SOFA) scores were calculated on day 1 of admission...
October 1, 2012: Chest
https://www.readbyqxmd.com/read/23402373/heparin-binding-protein-hbp-in-critically-ill-patients-with-influenza-a-h1n1-infection
#8
K-M Kaukonen, R Linko, H Herwald, L Lindbom, E Ruokonen, T Ala-Kokko, V Pettilä
Heparin-binding protein (HBP) is an inducer of vascular endothelial leakage in severe infections. Fluid accumulation into alveoli is a general finding in acute respiratory distress syndrome (ARDS). Severe acute respiratory failure with ARDS is a complication of influenza A(H1N1) infection. Accordingly, we studied the HBP levels in critically ill patients with infection of influenza A(H1N1).Critically ill patients in four intensive care units (ICUs) with polymerase chain reaction (PCR) confirmed infection of influenza A(H1N1) were prospectively evaluated...
December 2013: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/23361625/surviving-sepsis-campaign-international-guidelines-for-management-of-severe-sepsis-and-septic-shock-2012
#9
R P Dellinger, Mitchell M Levy, Andrew Rhodes, Djillali Annane, Herwig Gerlach, Steven M Opal, Jonathan E Sevransky, Charles L Sprung, Ivor S Douglas, Roman Jaeschke, Tiffany M Osborn, Mark E Nunnally, Sean R Townsend, Konrad Reinhart, Ruth M Kleinpell, Derek C Angus, Clifford S Deutschman, Flavia R Machado, Gordon D Rubenfeld, Steven Webb, Richard J Beale, Jean-Louis Vincent, Rui Moreno
OBJECTIVE: To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008. DESIGN: A consensus committee of 68 international experts representing 30 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict of interest policy was developed at the onset of the process and enforced throughout...
February 2013: Intensive Care Medicine
https://www.readbyqxmd.com/read/23353941/surviving-sepsis-campaign-international-guidelines-for-management-of-severe-sepsis-and-septic-shock-2012
#10
R Phillip Dellinger, Mitchell M Levy, Andrew Rhodes, Djillali Annane, Herwig Gerlach, Steven M Opal, Jonathan E Sevransky, Charles L Sprung, Ivor S Douglas, Roman Jaeschke, Tiffany M Osborn, Mark E Nunnally, Sean R Townsend, Konrad Reinhart, Ruth M Kleinpell, Derek C Angus, Clifford S Deutschman, Flavia R Machado, Gordon D Rubenfeld, Steven A Webb, Richard J Beale, Jean-Louis Vincent, Rui Moreno
OBJECTIVE: To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008. DESIGN: A consensus committee of 68 international experts representing 30 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict of interest policy was developed at the onset of the process and enforced throughout...
February 2013: Critical Care Medicine
https://www.readbyqxmd.com/read/23100007/supar-and-pai-1-in-critically-ill-mechanically-ventilated-patients
#11
MULTICENTER STUDY
Ville Jalkanen, Runkuan Yang, Rita Linko, Heini Huhtala, Marjatta Okkonen, Tero Varpula, Ville Pettilä, Jyrki Tenhunen
PURPOSE: SuPAR (soluble urokinase plasminogen activator receptor) and PAI-1 (plasminogen activator inhibitor 1) are active in the coagulation-fibrinolysis pathway. Both have been suggested as biomarkers for disease severity. We evaluated them in prediction of mortality, acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), sepsis and renal replacement therapy (RRT) in operative and non-operative ventilated patients. METHODS: We conducted a prospective, multicenter, observational study...
March 2013: Intensive Care Medicine
https://www.readbyqxmd.com/read/23074408/extracorporeal-lung-support-technologies-bridge-to-recovery-and-bridge-to-lung-transplantation-in-adult-patients-an-evidence-based-analysis
#12
(no author information available yet)
UNLABELLED: For cases of acute respiratory distress syndrome (ARDS) and progressive chronic respiratory failure, the first choice or treatment is mechanical ventilation. For decades, this method has been used to support critically ill patients in respiratory failure. Despite its life-saving potential, however, several experimental and clinical studies have suggested that ventilator-induced lung injury can adversely affect the lungs and patient outcomes. Current opinion is that by reducing the pressure and volume of gas delivered to the lungs during mechanical ventilation, the stress applied to the lungs is eased, enabling them to rest and recover...
2010: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/22957224/goal-oriented-respiratory-management-for-critically-ill-patients-with-acute-respiratory-distress-syndrome
#13
Carmen Sílvia Valente Barbas, Gustavo Faissol Janot Matos, Marcelo Britto Passos Amato, Carlos Roberto Ribeiro Carvalho
This paper, based on relevant literature articles and the authors' clinical experience, presents a goal-oriented respiratory management for critically ill patients with acute respiratory distress syndrome (ARDS) that can help improve clinicians' ability to care for these patients. Early recognition of ARDS modified risk factors and avoidance of aggravating factors during hospital stay such as nonprotective mechanical ventilation, multiple blood products transfusions, positive fluid balance, ventilator-associated pneumonia, and gastric aspiration can help decrease its incidence...
2012: Critical Care Research and Practice
https://www.readbyqxmd.com/read/22882846/mortality-and-morbidity-of-acute-hypoxemic-respiratory-failure-and-acute-respiratory-distress-syndrome-in-infants-and-young-children
#14
Yan-Feng Zhu, Feng Xu, Xiu-Lan Lu, Ying Wang, Jian-Li Chen, Jian-Xin Chao, Xiao-Wen Zhou, Jian-Hui Zhang, Yan-Zhi Huang, Wen-Liang Yu, Min-Hui Xie, Chao-Ying Yan, Zhu-Jin Lu, Bo Sun
BACKGROUND: Acute hypoxemic respiratory failure (AHRF) often develops acute respiratory distress syndrome (ARDS), and its incidence and mortalities in critically ill pediatric patients in China were 2% and 40% respectively. This study aimed at prospectively investigating incidence, causes, mortality and its risk factors, and any relationship to initial tidal volume (V(T)) levels of mechanical ventilation, in children £5 years of age with AHRF and ARDS. METHODS: In 12 consecutive months in 23 pediatric intensive care units (PICU), AHRF and ARDS were identified in those requiring > 12 hour intratracheal mechanical ventilation and followed up for 90 days or until death or discharge...
July 2012: Chinese Medical Journal
https://www.readbyqxmd.com/read/22801199/-efficacy-of-continuous-blood-purification-on-rescue-therapy-of-the-critically-ill-children-with-acute-lung-injury-and-acute-respiratory-distress-syndrome
#15
Yu-cai Zhang, Liang Xu, Qun-fang Rong, Yan Zhu, Rong-xin Chen
OBJECTIVE: To investigate the efficacy of continuous blood purification(CBP) in the treatment of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) in children. METHODS: One hundred and forty seven cases of ALI/ARDS were hospitalized to our pediatric intensive care unit, and 32 cases were treated with continuous blood purification (CBP) from June, 2006 to May, 2011. The model for CBP was continuous veno-venous hemofiltration dialysis (CVVHDF). CBP treatment persisted for at least 8 hours and replacement + dialysis fluid dose was 35 - 100 ml/(kg·h)...
March 2012: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/22507624/tumor-necrosis-factor-tnf-and-lymphotoxin-alpha-lta-single-nucleotide-polymorphisms-importance-in-ards-in-septic-pediatric-critically-ill-patients
#16
Z M Azevedo, D B Moore, F C Lima, C C Cardoso, R Bougleux, G I Matos, R A Luz, P Xavier-Elsas, E P Sampaio, M I Gaspar-Elsas, M O Moraes
Accumulating evidence indicates that genetic background influences the outcome of sepsis, which despite medical advances continues to be a major cause of morbidity and mortality. This study aimed to evaluate the influence of SNPs LTA +252A>G, TNF-863C>A and TNF-308G>A on susceptibility to sepsis, acute respiratory distress syndrome (ARDS), septic shock and sepsis mortality. A prospective case-control study was carried out in a Brazilian pediatric intensive care unit and included 490 septic pediatric patients submitted to mechanical ventilation and 610 healthy children...
June 2012: Human Immunology
https://www.readbyqxmd.com/read/22461369/inflammasome-regulated-cytokines-are-critical-mediators-of-acute-lung-injury
#17
COMPARATIVE STUDY
Tamás Dolinay, Young Sam Kim, Judie Howrylak, Gary M Hunninghake, Chang Hyeok An, Laura Fredenburgh, Anthony F Massaro, Angela Rogers, Lee Gazourian, Kiichi Nakahira, Jeffrey A Haspel, Roberto Landazury, Sabitha Eppanapally, Jason D Christie, Nuala J Meyer, Lorraine B Ware, David C Christiani, Stefan W Ryter, Rebecca M Baron, Augustine M K Choi
RATIONALE: Despite advances in clinical management, there are currently no reliable diagnostic and therapeutic targets for acute respiratory distress syndrome (ARDS). The inflammasome/caspase-1 pathway regulates the maturation and secretion of proinflammatory cytokines (e.g., IL-18). IL-18 is associated with injury in animal models of systemic inflammation. OBJECTIVES: We sought to determine the contribution of the inflammasome pathway in experimental acute lung injury and human ARDS...
June 1, 2012: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/22323569/the-changing-pattern-of-acute-respiratory-distress-syndrome-over-time-a-comparison-of-two-periods
#18
COMPARATIVE STUDY
Charalampos Pierrakos, Jean-Louis Vincent
This study aimed to assess whether patterns and outcomes of acute respiratory distress syndrome (ARDS) have changed due to improvements in mechanical ventilation techniques and support of critically ill patients, by comparing patients from two different periods in the same hospital. We reviewed data from all patients with a diagnosis of ARDS (according to American-European Consensus Conference criteria) who were treated in our multidisciplinary department of intensive care (Erasme Hospital, Brussels) between January 2006 and April 2009 (group B, n=210) and compared them with our previously reported data (January 1993 to February 1995) (group A, n=129)...
September 2012: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/22120856/clinical-characteristics-and-outcomes-of-patients-with-acute-lung-injury-and-ards
#19
R R Bhadade, R A de Souza, M J Harde, A Khot
BACKGROUND: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are critical illnesses associated with significant morbidity and mortality. AIMS: This was designed to assess various etiologies of ALI/ARDS, to determine the correlation between the diagnostic criteria and need of mechanical ventilation, and to correlate biochemical factors with the outcome of patients. SETTINGS AND DESIGN: An observational, prospective study was conducted in a medical intensive care unit (MICU) of a tertiary care hospital, for a period of 1 year...
October 2011: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/22065262/critically-ill-children-during-the-2009-2010-influenza-pandemic-in-the-united-states
#20
MULTICENTER STUDY
Adrienne G Randolph, Frances Vaughn, Ryan Sullivan, Lewis Rubinson, B Taylor Thompson, Grace Yoon, Elizabeth Smoot, Todd W Rice, Laura L Loftis, Mark Helfaer, Allan Doctor, Matthew Paden, Heidi Flori, Christopher Babbitt, Ana Lia Graciano, Rainer Gedeit, Ronald C Sanders, John S Giuliano, Jerry Zimmerman, Timothy M Uyeki
BACKGROUND: The 2009 pandemic influenza A (H1N1) (pH1N1) virus continues to circulate worldwide. Determining the roles of chronic conditions and bacterial coinfection in mortality is difficult because of the limited data for children with pH1N1-related critical illness. METHODS: We identified children (<21 years old) with confirmed or probable pH1N1 admitted to 35 US PICUs from April 15, 2009, through April 15, 2010. We collected data on demographics, baseline health, laboratory results, treatments, and outcomes...
December 2011: Pediatrics
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