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https://www.readbyqxmd.com/read/28211229/serum-micrornas-as-predictors-for-liver-fibrosis-staging-in-hepatitis-c-virus-associated-chronic-liver-disease-patients
#1
Olfat G Shaker, Mahmoud A Senousy
Accurate staging of liver fibrosis is important for clinical decision making and personalized management. Liver fibrosis is influenced by patients' genomics, including IFNL3 genotype and microRNA expression. However, incorporating microRNAs into fibrosis prediction algorithms has not been investigated. We examined the potential of 8 selected serum microRNAs; miR-122, miR-126, miR-129, miR-199a, miR-155, miR-203a, miR-221, and miR-223 as non-invasive biomarkers to stage liver fibrosis in HCV-associated chronic liver disease (HCV-CLD)...
February 17, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28202850/hypermethylation-of-the-n-myc-downstream-regulated-gene-2-promoter-in-peripheral-blood-mononuclear-cells-is-associated-with-liver-fibrosis-in-chronic-hepatitis-b
#2
Xin-Yuan Liu, Yu-Chen Fan, Shuai Gao, Jing Zhao, Feng Li, Jun Zhang, Kai Wang
DNA methylation is a fundamental epigenetic modification to regulate gene expression. N-Myc downstream-regulated gene (NDRG) 2 is a cytoplasmic protein and participates in the pathogenesis of liver fibrosis. In this study, the mRNA expression and methylation status of NDRG2 was evaluated in patients with chronic hepatitis B (CHB). The study included 143 CHB patients and 65 normal controls (NC). The mRNA expression of NDRG2 in peripheral blood mononuclear cells (PBMCs) was detected by quantitative real-time polymerase chain reaction...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28195363/liver-fibrosis-scores-predict-liver-disease-mortality-in-the-united-states-population
#3
Aynur Unalp-Arida, Constance E Ruhl
BACKGROUND AND RATIONALE: Fatty liver disease is common in the United States and worldwide due to changing lifestyles and can progress to fibrosis and cirrhosis contributing to premature death. We examined whether liver fibrosis scores were associated with increased overall and disease-specific mortality in a U.S. population-based prospective survey with up to 23 years of linked-mortality data. METHODS: Data were analyzed from 14,841 viral hepatitis negative adult participants in the third National Health and Nutrition Examination Survey, 1988-1994...
February 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28195177/prevalence-of-nonalcoholic-steatohepatitis-associated-cirrhosis-in-the-united-states-an-analysis-of-national-health-and-nutrition-examination-survey-data
#4
Mohammad Nasser Kabbany, Praveen Kumar Conjeevaram Selvakumar, Kymberly Watt, Rocio Lopez, Zade Akras, Nizar Zein, William Carey, Naim Alkhouri
OBJECTIVES: Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of manifestations ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), fibrosis and eventually cirrhosis. The prevalence of NAFLD has been shown to be increasing over time; however, the prevalence of NASH cirrhosis and advanced fibrosis over time has not been well studied. Estimate the changes in prevalence of NASH cirrhosis and NAFLD-associated advanced fibrosis among adults in the United States...
February 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28180191/doppler-ultrasonography-combined-with-transient-elastography-improves-the-non-invasive-assessment-of-fibrosis-in-patients-with-chronic-liver-diseases
#5
Tamara Alempijevic, Simon Zec, Vladimir Nikolic, Aleksandar Veljkovic, Zoran Stojanovic, Vera Matovic, Tomica Milosavljevic
AIMS: Accurate clinical assessment of liver fibrosis is essential and the aim of our study was to compare and combine hemodynamic Doppler ultrasonography, liver stiffness by transient elastography, and non-invasive serum biomarkers with the degree of fibrosis confirmed by liver biopsy, and thereby to determine the value of combining non-invasive method in the prediction significant liver fibrosis. MATERIAL AND METHODS: We included 102 patients with chronic liver disease of various etiology...
January 31, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28177543/changes-in-liver-stiffness-measurements-and-fibrosis-scores-following-sofosbuvir-based-treatment-regimens-without-interferon
#6
Aisha Elsharkawy, Shereen Abdel Alem, Rabab Fouad, Maissa El Raziky, Wafaa El Akel, Mahmoud Abdo, Omnia Tantawi, Mohamed AbdAllah, Marc Bourliere, Gamal Esmat
BACKGROUND AND AIM: Accurate evaluation of the degree of liver fibrosis in patients with chronic liver diseases is crucial, as liver fibrosis is important in order to make therapeutic decisions, determine prognosis of liver disease and to follow-up disease progression. Multiple non-invasive methods have been used successfully in the prediction of fibrosis however early changes in non-invasive biomarkers of hepatic fibrosis under effective antiviral therapy are widely unknown. AIM: To evaluate changes of Transient elastography values as well as FIB-4 and AST to platelet ratio index in patients (APRI) treated with sofosbuvir- based treatment regimen...
February 8, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28169971/health-related-quality-of-life-in-pediatric-patients-with-chronic-hepatitis-b-living-in-the-united-states-and-canada
#7
Sarah Jane Schwarzenberg, Simon C Ling, Yona Keich Cloonan, Hsing-Hua S Lin, Donna M Evon, Karen F Murray, Norberto Rodriguez-Baez, Philip Rosenthal, Jeffrey Teckman, Kathleen B Schwarz
OBJECTIVES: To determine if selected socio-demographic and HBV-specific clinical factors are associated with health-related quality of life (HRQoL) among pediatric patients chronically infected with hepatitis B virus (HBV). METHODS: Children with chronic HBV enrolled in the Hepatitis B Research Network completed the Child Health Questionnaire (CHQ) at study entry. Caregivers of children 5- < 10 years completed the parent-reported PF50; youth 10- < 18 years completed the child-reported CF87...
February 4, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28164635/microrna-122-as-a-novel-non-invasive-marker-of-liver-fibrosis-in-hepatitis-c-virus-patients
#8
Ahmed A S Omran, Khalid S Osman, Hanan M Kamel, Emad A Abdel-Naem, Dalia E El-Deen Hasan
BACKGROUND: Noninvasive evaluation of hepatic fibrosis is a growing scientific effort in medicine and is of particular interest as early diagnosis is important for the timely prevention and treatment of liver fibrosis and cirrhosis. Non-invasive markers of liver fibrosis have recently been developed as an alternative to liver biopsy. Aim of the work: The aim of this study was to assess the diagnostic value of serum microRNA 122 in Egyptian chronic hepatitis C virus infected patients. This may be a useful tool as a non invasive diagnostic test to detect early stages of fibrosis in comparison to 4 non invasive indexes (APRI, Forns, FIB-4, and FI) vs...
July 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28130908/apri-and-fib4-as-effective-markers-for-monitoring-esophageal-varices-in-hiv-hcv-co-infected-patients-due-to-contaminated-blood-products-for-hemophilia
#9
Koji Natsuda, Mitsuhisa Takatsuki, Takayuki Tanaka, Akihiko Soyama, Tomohiko Adachi, Shinichiro Ono, Takanobu Hara, Zhassulan Baimakhanov, Hajime Imamura, Satomi Okada, Masaaki Hidaka, Susumu Eguchi
AIM: We examined the feasibility of the aspartate transaminase (AST)-platelet ratio index (APRI) and FIB4, which are well-established markers for liver fibrosis, as indicators for monitoring esophageal varices in patients who were co-infected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) due to contaminated blood products for hemophilia in Japan. PATIENTS AND METHODS: Forty-three HIV/HCV co-infected patients were enrolled. All were hemophilic men (median age 41, range 29-66 yrs)...
January 28, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28130852/a-novel-noninvasive-algorithm-for-the-assessment-of-liver-fibrosis-in-patients-with-chronic-hepatitis-b-virus-infection
#10
Ming-Yu Zhu, Xia Zou, Qiang Li, De-Min Yu, Zhi-Tao Yang, Dao Huang, Jie Chen, Qi-Ming Gong, Dong-Hua Zhang, Yan Zhang, Liang Chen, Pei-Zhan Chen, Xin-Xin Zhang
Several noninvasive blood biomarkers have been established for the assessment of liver fibrosis in patients with chronic hepatitis B virus (HBV) infection, but their clinical performance remains inconclusive. Here, we compared the diagnostic performance of these biomarkers and developed a novel algorithm for assessing liver fibrosis. Six hundred and sixteen chronic HBV-infected and treatment-naïve patients who underwent liver biopsy were enrolled and randomly divided into training (N = 410) and internal validation cohorts (N = 206)...
January 27, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28127890/microrna-profile-analysis-in-the-liver-fibrotic-tissues-of-chronic-hepatitis-b-patients
#11
Rong Chen, Jun-Cheng Wu, Ting Liu, Ying Qu, Lun-Gen Lu, Ming-Yi Xu
OBJECTIVE: The miRNAs play an important role in the development of human fibrosis diseases. However, the mechanisms of miRNA related to liver fibrosis are not fully exploited. Our study aims to identify the miRNAs features during fibrotic stage S0 to S4,which would be associated with hepatitis B virus (HBV) related liver fibrosis. METHED: Liver tissues were collected from 40 chronic hepatitis B (CHB) patients with fibrotic from stage S0 to S4. Microarray of miRNA and genomic informatics analysis were performed...
January 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28105257/ultrasound-shear-wave-elastography-and-liver-fibrosis-a-prospective-multicenter-study
#12
Joyce Anyona Sande, Suleman Verjee, Sudhir Vinayak, Farin Amersi, Munir Ghesani
AIM: To assess the accuracy of shear wave elastography (SWE) alone and in combination with aminotransferase platelet ratio index (APRI) score in the staging of liver fibrosis. METHODS: A multicenter prospective study was conducted to assess the accuracy of SWE (medians) and APRI to predict biopsy results. The analysis focused on distinguishing the different stages of liver disease, namely, F0 from F1-4, F0-1 from F2-4, F0-2 from F3-4 and F0-3 from F4; F0-F1 from F2-F4 being of primary interest...
January 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28100410/comp-serum-levels-a-new-non-invasive-biomarker-of-liver-fibrosis-in-patients-with-chronic-viral-hepatitis
#13
Kalliopi Zachou, Stella Gabeta, Zakera Shums, Nikolaos K Gatselis, George K Koukoulis, Gary L Norman, George N Dalekos
BACKGROUND & AIMS: Recently we have shown that cartilage oligomeric matrix protein (COMP), a fibrillar collagen assembly regulator, is strongly associated with cirrhosis and hepatocellular carcinoma progression. Therefore, we assessed whether serum COMP levels can be used as a non-invasive fibrosis marker in patients with chronic viral hepatitis (CVH) and compared this marker with standard methods for disease stage assessment [histology, transient elastography (TE), APRI, FIB-4]. METHODS: Sera from 116 CVH patients, 66 HBV [24 female; median age 53(22-76)] and 50 HCV [21 female; median age 48...
January 15, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28095797/cocaine-crack-use-is-not-associated-with-fibrosis-progression-measured-by-ast-to-platelet-ratio-index-in-hiv-hcv-co-infected-patients-a-cohort-study
#14
Valérie Martel-Laferrière, Roy Nitulescu, Joseph Cox, Curtis Cooper, Mark Tyndall, Danielle Rouleau, Sharon Walmsley, Leo Wong, Marina B Klein
BACKGROUND: Cocaine and crack use has been associated with HIV and HCV infections, but its consequences on HCV progression have not been well established. We analyzed the impact of cocaine/crack use on liver fibrosis progression in a cohort of HIV-HCV co-infected patients. METHODS: A Canadian multicenter prospective cohort study followed 1238 HIV-HCV co-infected persons every 6 months between 2003 and 2013. Data were analyzed from 573 patients with positive HCV RNA, not on HCV treatment, without significant liver fibrosis (AST-to-Platelet Ratio Index (APRI) <1...
January 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28078847/real-time-shear-wave-elastrography-and-apri-index-for-evaluating-autoimmune-hepatitis-fibrosis
#15
L L Sun, G Dong, B Wang, Q Zheng, S Wang, R F Zhang
The objective of this study was to investigate the significance of real-time supersonic shear imaging (SSI) and serum biochemical index in evaluating the degree of autoimmune hepatitis fibrosis. Retrospective analysis was carried out to study 291 cases of patients with autoimmune hepatitis, and discuss the value of SSI application, APRI index and bilirubin on autoimmune hepatitis. The area under the receiver operating characteristic curve (AUROC) was taken for statistical analysis to determine its diagnostic accuracy...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28070199/performance-and-utility-of-transient-elastography-and-non-invasive-markers-of-liver-fiibrosis-in-patients-with-autoimmune-hepatitis-a-single-centre-experience
#16
Olympia E Anastasiou, Matthias Büchter, Hideo A Baba, Johannes Korth, Ali Canbay, Guido Gerken, Alisan Kahraman
OBJECTIVES: Autoimmune hepatitis (AIH) is a relatively rare cause of hepatic dysfunction, which can lead to acute liver failure (ALV) and cirrhosis if not treated. The performance of transient elastography (TE) compared to liver biopsy has been evaluated in many liver diseases. The aim of the present study was to evaluate the performance of TE and other non-invasive markers for liver fiibrosis in patients with biopsy-proven AIH. METHODS: Fifty-three patients who were treated at the department of gastroenterology and hepatology of the University Clinic Essen from 2008 to 2013 included in this retrospective study...
November 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/28067683/acoustic-radiation-force-impulse-elastography-comparison-and-combination-with-other-noninvasive-tests-for-the-diagnosis-of-compensated-liver-cirrhosis
#17
Lukas Pfeifer, Werner Adler, Steffen Zopf, Jürgen Siebler, Dane Wildner, Ruediger S Goertz, Barbara Schellhaas, Markus F Neurath, Deike Strobel
BACKGROUND AND AIMS: The aim of this study was to compare acoustic radiation force impulse (ARFI) elastography with other noninvasive tests and to develop a new score for the assessment of liver fibrosis/cirrhosis. MATERIALS AND METHODS: B-mode ultrasound (including high-frequency liver surface evaluation), routine blood tests, ARFI quantification, and mini-laparoscopic liver evaluation were obtained in compensated patients scheduled for mini-laparoscopic biopsy...
January 6, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28065745/alteration-of-methyl-cpg-binding-domain-family-in-patients-with-chronic-hepatitis-b
#18
Jing Zhao, Yu-Chen Fan, Long-Yan Chen, Shuai Gao, Feng Li, Kai Wang
BACKGROUND AND OBJECTIVE: Epigenetics contributes to the outcome of chronic hepatitis B virus (HBV) infection. However, the role of methyl-CpG binding domain (MBD) family in the natural history of chronic hepatitis B (CHB) has not been demonstrated. It is aimed to investigate the dynamic expression of MBD family and assess the potential association of MBD family in the progression of CHB. METHODS: Quantitative real-time polymerase chain reaction (RT-PCR) was used to determine the mRNA levels of MBD family in peripheral blood mononuclear cells (PBMCs) from 223 patients with CHB as training cohort, 146 patients with CHB as validation cohort [immune-tolerant (IT), immune clearance (IC), non/low-replicative (LR) and HBeAg negative hepatitis (ENH)], and 14 healthy controls (HCs)...
January 5, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28054587/method-for-removing-spectral-contaminants-to-improve-analysis-of-raman-imaging-data
#19
Xun Zhang, Sheng Chen, Zhe Ling, Xia Zhou, Da-Yong Ding, Yoon Soo Kim, Feng Xu
The spectral contaminants are inevitable during micro-Raman measurements. A key challenge is how to remove them from the original imaging data, since they can distort further results of data analysis. Here, we propose a method named "automatic pre-processing method for Raman imaging data set (APRI)", which includes the adaptive iteratively reweighted penalized least-squares (airPLS) algorithm and the principal component analysis (PCA). It eliminates the baseline drifts and cosmic spikes by using the spectral features themselves...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28039877/noninvasive-assessment-of-liver-fibrosis-stage-using-ultrasound-based-shear-wave-velocity-measurements-and-serum-algorithms-in-patients-with-viral-hepatitis-b-a-retrospective-cohort-study
#20
Jianxue Liu, Junzhi Zhao, Yaoren Zhang, Yonghao Ji, Shumei Lin, Guoliang Dun, Sujuan Guo
OBJECTIVES: Liver biopsy remains the reference standard for the assessment of liver fibrosis, but this procedure is invasive and can lead to complications. Thus, studies to determine the optimal noninvasive test are warranted. This study compared several noninvasive tests and their combinations for evaluating liver fibrosis stages in patients with chronic hepatitis B. METHODS: The shear wave velocity (SWV) and laboratory indicators were collected from 174 patients with chronic hepatitis B...
February 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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