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https://www.readbyqxmd.com/read/28318912/less-liver-fibrosis-in-metabolically-healthy-compared-with-metabolically-unhealthy-obese-patients-with-non-alcoholic-fatty-liver-disease
#1
Y Gutiérrez-Grobe, E Juárez-Hernández, B A Sánchez-Jiménez, M H Uribe-Ramos, M H Ramos-Ostos, M Uribe, N C Chávez-Tapia
AIM: This cross-sectional study evaluated liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD), and compared the characteristics of metabolically healthy obese (MHO) with metabolically unhealthy obese (MUHO) patients. METHODS: The study was nested within a randomized clinical trial (RCT) and included obese patients with NAFLD, as determined by liver ultrasonography. Fibrosis was assessed by transient elastography, and AST-to-platelet ratio index (APRI) and NAFLD score...
March 16, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28297803/-correlation-of-liver-stiffness-measured-by-fibrotouch-and-fibroscan-with-ishak-fibrosis-score-in-patients-with-chronic-hepatitis-b
#2
G F Chen, J Ping, H T Gu, Z M Zhao, Y Zhou, F Xing, Y Y Tao, Y P Mu, P Liu, C H Liu
Objective: To investigate the correlation of liver stiffness measured by FibroTouch (FT) and FibroScan (FS) with Ishak fibrosis score in patients with chronic hepatitis B. Methods: A total of 313 patients with chronic hepatitis B who visited Department of Liver Cirrhosis in Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from November 2014 to May 2016 were enrolled. All the patients underwent liver biopsy, and FT and FS were used to determine liver stiffness measurement (LSM)...
February 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28293380/fibrosis-assessment-using-fibrometer-combined-to-first-generation-tests-in-hepatitis-c
#3
Maria Chiara Chindamo, Jerome Boursier, Ronir Raggio Luiz, Isabelle Fouchard-Hubert, Vera Lúcia Nunes Pannain, João Marcello de Araújo Neto, Henrique Sérgio Moraes Coelho, Renata de Mello Perez, Paul Calès, Cristiane Alves Villela-Nogueira
AIM: To evaluate the performance of FibroMeter(Virus3G) combined to the first generation tests aspartate aminotransferase-to-platelet ratio index (APRI) or Forns index to assess significant fibrosis in chronic hepatitis C (CHC). METHODS: First generation tests APRI or Forns were initially applied in a derivation population from Rio de Janeiro in Brazil considering cut-offs previously reported in the literature to evaluate significant fibrosis. FibroMeter(Virus3G) was sequentially applied to unclassified cases from APRI or Forns...
February 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28267407/the-evolving-relationship-between-adiponectin-and-insulin-sensitivity-in-hepatitis-c-patients-during-viral-clearance
#4
Ming-Ling Chang, Chia-Jung Kuo, Li-Heng Pao, Chen-Ming Hsu, Cheng-Tang Chiu
BACKGROUND: The evolution of the relationship between adiponectin and insulin sensitivity in hepatitis C virus (HCV) patients during viral clearance is unclear and warrants investigation. METHODS: A prospective study including 747 consecutive chronic hepatitis C (CHC) patients, of whom 546 had completed a course of anti-HCV therapy and underwent pre-, peri- and post-therapy surveys for anthropomorphic, viral, metabolic and hepatic profiles and adiponectin levels, was conducted in a tertiary care center...
March 7, 2017: Virulence
https://www.readbyqxmd.com/read/28247581/vap-score-as-a-novel-non-invasive-liver-fibrosis-model-in-patients-with-chronic-hepatitis-c
#5
H Elham Ahmed Hassan, Sharaf E L-Din Abd El-Rehim, Zain El-Abdeen Ahmed Sayed, Emad Farah Mohamed Kholef, Abeer Sabry, Noha Abd El-Rehim Abo Elhagag
AIM: Assessment of liver fibrosis in chronic hepatitis C (CHC) patients is necessary before antiviral treatment. This study aimed to evaluate the effectiveness of eight noninvasive models (AAR, APRI, FCI, FI, FIB-4, FibroQ, King and VITRO scores) for predicting fibrosis compared with liver biopsy and to create a new score for predicting different fibrosis stages with increased accuracy. METHODS: We prospectively studied 127 treatment-naive CHC patients who underwent liver biopsy...
February 28, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28243319/comparison-of-fib-4-index-and-aspartate-aminotransferase-to-platelet-ratio-index-on-carcinogenesis-in-chronic-hepatitis-b-treated-with-entecavir
#6
Hiroki Nishikawa, Norihiro Nishijima, Hirayuki Enomoto, Azusa Sakamoto, Akihiro Nasu, Hideyuki Komekado, Takashi Nishimura, Ryuichi Kita, Toru Kimura, Hiroko Iijima, Shuhei Nishiguchi, Yukio Osaki
AIMS: We sought to compare the effects of FIB-4 index and aspartate aminotransferase to platelet ratio index (APRI) on hepatocellular carcinoma (HCC) incidence in chronic hepatitis B (CHB) patients undergoing entecavir (ETV) therapy. PATIENT AND METHODS: A total of 338 nucleosides analogue therapy naïve CHB patients initially treated with ETV were analyzed. The optimal cutoff points in each continuous variable were determined by receiver operating curve (ROC) analysis...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28225987/can-fib4-and-nafld-fibrosis-scores-help-endocrinologists-refer-patients-with-non-alcoholic-fat-liver-disease-to-a-hepatologist
#7
Rodrigo Bremer Nones, Cláudia Pontes Ivantes, Maria Lucia Alves Pedroso
Objective: The objective of this study is to evaluate the performance of mathematical models used in non-invasive diagnosis of liver fibrosis in nonalcoholic fatty liver disease (NAFLD) patients to determine when the patient needs to be referred to a hepatologist. Subjects and methods: Patients referred by endocrinologists to the liver outpatient departments in two hospitals in Curitiba, Brazil, over a 72-month period were analyzed. The results calculated using the APRI, FIB 4, FORNS and NAFLD Fibrosis Score non-invasive liver fibrosis assessment models were analyzed and compared with histological staging of this population...
February 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28222249/are-non-invasive-fibrosis-markers-for-chronic-hepatitis-b-reliable-in-sub-saharan-africa
#8
Hailemichael Desalegn, Hanna Aberra, Nega Berhe, Svein Gunnar Gundersen, Asgeir Johannessen
BACKGROUND: In the absence of liver biopsy, the World Health Organization (WHO) recommends non-invasive tests, such as APRI (aspartate aminotransferase to platelet ratio index) and FIB-4, to assess liver fibrosis in patients with chronic hepatitis B (CHB). However, these tests are not well validated in sub-Saharan Africa. Recently, a new marker, GPR (gamma-glutamyl transpeptidase to platelet ratio), was found to be more accurate in an African setting, but this needs confirmation in other cohorts...
February 21, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28211229/serum-micrornas-as-predictors-for-liver-fibrosis-staging-in-hepatitis-c-virus-associated-chronic-liver-disease-patients
#9
Olfat G Shaker, Mahmoud A Senousy
Accurate staging of liver fibrosis is important for clinical decision making and personalized management. Liver fibrosis is influenced by patients' genomics, including IFNL3 genotype and microRNA expression. However, incorporating microRNAs into fibrosis prediction algorithms has not been investigated. We examined the potential of 8 selected serum microRNAs; miR-122, miR-126, miR-129, miR-199a, miR-155, miR-203a, miR-221, and miR-223 as non-invasive biomarkers to stage liver fibrosis in HCV-associated chronic liver disease (HCV-CLD)...
February 17, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28202850/hypermethylation-of-the-n-myc-downstream-regulated-gene-2-promoter-in-peripheral-blood-mononuclear-cells-is-associated-with-liver-fibrosis-in-chronic-hepatitis-b
#10
Xin-Yuan Liu, Yu-Chen Fan, Shuai Gao, Jing Zhao, Feng Li, Jun Zhang, Kai Wang
DNA methylation is a fundamental epigenetic modification to regulate gene expression. N-Myc downstream-regulated gene (NDRG) 2 is a cytoplasmic protein and participates in the pathogenesis of liver fibrosis. In this study, the mRNA expression and methylation status of NDRG2 was evaluated in patients with chronic hepatitis B (CHB). The study included 143 CHB patients and 65 normal controls (NC). The mRNA expression of NDRG2 in peripheral blood mononuclear cells (PBMCs) was detected by quantitative real-time polymerase chain reaction...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28195363/liver-fibrosis-scores-predict-liver-disease-mortality-in-the-united-states-population
#11
Aynur Unalp-Arida, Constance E Ruhl
BACKGROUND AND RATIONALE: Fatty liver disease is common in the United States and worldwide due to changing lifestyles and can progress to fibrosis and cirrhosis contributing to premature death. We examined whether liver fibrosis scores were associated with increased overall and disease-specific mortality in a U.S. population-based prospective survey with up to 23 years of linked-mortality data. METHODS: Data were analyzed from 14,841 viral hepatitis negative adult participants in the third National Health and Nutrition Examination Survey, 1988-1994...
February 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28195177/prevalence-of-nonalcoholic-steatohepatitis-associated-cirrhosis-in-the-united-states-an-analysis-of-national-health-and-nutrition-examination-survey-data
#12
Mohammad Nasser Kabbany, Praveen Kumar Conjeevaram Selvakumar, Kymberly Watt, Rocio Lopez, Zade Akras, Nizar Zein, William Carey, Naim Alkhouri
OBJECTIVES: Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of manifestations ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), fibrosis and eventually cirrhosis. The prevalence of NAFLD has been shown to be increasing over time; however, the prevalence of NASH cirrhosis and advanced fibrosis over time has not been well studied. Estimate the changes in prevalence of NASH cirrhosis and NAFLD-associated advanced fibrosis among adults in the United States...
February 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28180191/doppler-ultrasonography-combined-with-transient-elastography-improves-the-non-invasive-assessment-of-fibrosis-in-patients-with-chronic-liver-diseases
#13
Tamara Alempijevic, Simon Zec, Vladimir Nikolic, Aleksandar Veljkovic, Zoran Stojanovic, Vera Matovic, Tomica Milosavljevic
AIMS: Accurate clinical assessment of liver fibrosis is essential and the aim of our study was to compare and combine hemodynamic Doppler ultrasonography, liver stiffness by transient elastography, and non-invasive serum biomarkers with the degree of fibrosis confirmed by liver biopsy, and thereby to determine the value of combining non-invasive method in the prediction significant liver fibrosis. MATERIAL AND METHODS: We included 102 patients with chronic liver disease of various etiology...
January 31, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28177543/changes-in-liver-stiffness-measurements-and-fibrosis-scores-following-sofosbuvir-based-treatment-regimens-without-interferon
#14
Aisha Elsharkawy, Shereen Abdel Alem, Rabab Fouad, Maissa El Raziky, Wafaa El Akel, Mahmoud Abdo, Omnia Tantawi, Mohamed AbdAllah, Marc Bourliere, Gamal Esmat
BACKGROUND AND AIM: Accurate evaluation of the degree of liver fibrosis in patients with chronic liver diseases is crucial, as liver fibrosis is important in order to make therapeutic decisions, determine prognosis of liver disease and to follow-up disease progression. Multiple non-invasive methods have been used successfully in the prediction of fibrosis however early changes in non-invasive biomarkers of hepatic fibrosis under effective antiviral therapy are widely unknown. AIM: To evaluate changes of Transient elastography values as well as FIB-4 and AST to platelet ratio index in patients (APRI) treated with sofosbuvir- based treatment regimen...
February 8, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28169971/health-related-quality-of-life-in-pediatric-patients-with-chronic-hepatitis-b-living-in-the-united-states-and-canada
#15
Sarah Jane Schwarzenberg, Simon C Ling, Yona Keich Cloonan, Hsing-Hua S Lin, Donna M Evon, Karen F Murray, Norberto Rodriguez-Baez, Philip Rosenthal, Jeffrey Teckman, Kathleen B Schwarz
OBJECTIVES: To determine if selected socio-demographic and HBV-specific clinical factors are associated with health-related quality of life (HRQoL) among pediatric patients chronically infected with hepatitis B virus (HBV). METHODS: Children with chronic HBV enrolled in the Hepatitis B Research Network completed the Child Health Questionnaire (CHQ) at study entry. Caregivers of children 5- < 10 years completed the parent-reported PF50; youth 10- < 18 years completed the child-reported CF87...
February 4, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28164635/microrna-122-as-a-novel-non-invasive-marker-of-liver-fibrosis-in-hepatitis-c-virus-patients
#16
Ahmed A S Omran, Khalid S Osman, Hanan M Kamel, Emad A Abdel-Naem, Dalia E El-Deen Hasan
BACKGROUND: Noninvasive evaluation of hepatic fibrosis is a growing scientific effort in medicine and is of particular interest as early diagnosis is important for the timely prevention and treatment of liver fibrosis and cirrhosis. Non-invasive markers of liver fibrosis have recently been developed as an alternative to liver biopsy. Aim of the work: The aim of this study was to assess the diagnostic value of serum microRNA 122 in Egyptian chronic hepatitis C virus infected patients. This may be a useful tool as a non invasive diagnostic test to detect early stages of fibrosis in comparison to 4 non invasive indexes (APRI, Forns, FIB-4, and FI) vs...
July 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28130908/aspartate-transaminase-platelet-ratio-and-fibrosis-4-indices-as-effective-markers-for-monitoring-esophageal-varices-in-hiv-hepatitis-c-virus-co-infected-patients-due-to-contaminated-blood-products-for-hemophilia
#17
Koji Natsuda, Mitsuhisa Takatsuki, Takayuki Tanaka, Akihiko Soyama, Tomohiko Adachi, Shinichiro Ono, Takanobu Hara, Zhassulan Baimakhanov, Hajime Imamura, Satomi Okada, Masaaki Hidaka, Susumu Eguchi
AIM: We examined the feasibility of the aspartate transaminase (AST)-platelet ratio index (APRI) and Fibrosis-4 (FIB4) score, which are well-established markers for liver fibrosis, as indicators for monitoring esophageal varices in patients who were co-infected with HIV and hepatitis C virus (HCV) due to contaminated blood products for hemophilia in Japan. METHODS: Forty-three HIV/HCV co-infected patients were enrolled. All were hemophilic men (median age 41 years; range, 29-66 years)...
January 28, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28130852/a-novel-noninvasive-algorithm-for-the-assessment-of-liver-fibrosis-in-patients-with-chronic-hepatitis-b-virus-infection
#18
Ming-Yu Zhu, Xia Zou, Qiang Li, De-Min Yu, Zhi-Tao Yang, Dao Huang, Jie Chen, Qi-Ming Gong, Dong-Hua Zhang, Yan Zhang, Liang Chen, Pei-Zhan Chen, Xin-Xin Zhang
Several noninvasive blood biomarkers have been established for the assessment of liver fibrosis in patients with chronic hepatitis B virus (HBV) infection, but their clinical performance remains inconclusive. Here, we compared the diagnostic performance of these biomarkers and developed a novel algorithm for assessing liver fibrosis. Six hundred and sixteen chronic HBV-infected and treatment-naïve patients who underwent liver biopsy were enrolled and randomly divided into training (N = 410) and internal validation cohorts (N = 206)...
January 27, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28127890/microrna-profile-analysis-in-the-liver-fibrotic-tissues-of-chronic-hepatitis-b-patients
#19
Rong Chen, Jun-Cheng Wu, Ting Liu, Ying Qu, Lun-Gen Lu, Ming-Yi Xu
OBJECTIVE: The miRNAs play an important role in the development of human fibrosis diseases. However, the mechanisms of miRNA related to liver fibrosis are not fully exploited. Our study aims to identify the miRNAs features during fibrotic stage S0 to S4,which would be associated with hepatitis B virus (HBV) related liver fibrosis. METHED: Liver tissues were collected from 40 chronic hepatitis B (CHB) patients with fibrotic from stage S0 to S4. Microarray of miRNA and genomic informatics analysis were performed...
January 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28105257/ultrasound-shear-wave-elastography-and-liver-fibrosis-a-prospective-multicenter-study
#20
Joyce Anyona Sande, Suleman Verjee, Sudhir Vinayak, Farin Amersi, Munir Ghesani
AIM: To assess the accuracy of shear wave elastography (SWE) alone and in combination with aminotransferase platelet ratio index (APRI) score in the staging of liver fibrosis. METHODS: A multicenter prospective study was conducted to assess the accuracy of SWE (medians) and APRI to predict biopsy results. The analysis focused on distinguishing the different stages of liver disease, namely, F0 from F1-4, F0-1 from F2-4, F0-2 from F3-4 and F0-3 from F4; F0-F1 from F2-F4 being of primary interest...
January 8, 2017: World Journal of Hepatology
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