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Mizuki Yamamoto, Toshihiro Tokiwa, Miki Tobiume, Shigeru Akamatsu, Kayoko Matsuo, Junji Moribe, Kazunori Ike
Hepatozoon apri n. sp. is described from Japanese wild boars Sus scrofa leucomystax in Japan. The gamonts in the peripheral blood leukocytes were 11.6 ± 1.4 × 6.7 ± 1.3 μm in size. The meronts in the muscle tissues were 35.0-47.5 μm in length and 26.5-30 μm in width. A high rate (53.0%) of infection was found by nested PCR using muscle specimens from 181 wild boars captured in Tokushima, Japan. A phylogenetic analysis based on 18S rRNA gene sequences revealed that H. apri n. sp. detected in wild boars is closely related to Hepatozoon spp...
December 2017: International Journal for Parasitology. Parasites and Wildlife
Antonietta Romano, Paolo Angeli, Sara Piovesan, Franco Noventa, Georgios Anastassopoulos, Liliana Chemello, Luisa Cavalletto, Martina Gambato, Francesco Paolo Russo, Patrizia Burra, Valter Vincenzi, Pier Giorgio Scotton, Sandro Panese, Diego Tempesta, Tosca Bertin, Maurizio Carrara, Antonio Carlotto, Franco Capra, Giada Carolo, Giovanna Scroccaro, Alfredo Alberti
BACKGROUND & AIMS: Direct-acting antiviral agents (DAAs) are safe and effective in patients with hepatitis C. Conflicting data were reported on the risk of Hepatocellular carcinoma (HCC) during/after therapy with DAAs. Aim of this study was to evaluate incidence of newly diagnosed hepatocellular carcinoma and associated risk factors in patients with advanced hepatitis C treated with DAAs. METHODS: The study is based on the NAVIGATORE platform, a prospectively recording database of all patients with hepatitis C receiving DAAs in Veneto region (Italy)...
March 15, 2018: Journal of Hepatology
Xihui Jiang, Ya Wang, Zhengyan Su, Fang Yang, Houning Lv, Lin Lin, Chao Sun
We aimed to investigate the relationship between the histologic severity and red blood cell distribution width to platelet ratio (RPR) in patients with primary biliary cholangitis (PBC). One hundred and seven consecutive patients with liver biopsy-proven and as yet treatment-naïve PBC were enrolled as the primary and validation cohort. The histologic stages were divided into early stage (Scheuer's stage 1 & 2) and late stage (Scheuer's stage 3 & 4). The overall patient demographics, clinical manifestations, hematological tests and biochemical profile were retrospectively collected from our database...
March 13, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
Yunes Panahi, Parisa Kianpour, Reza Mohtashami, Stephen L Atkin, Alexandra E Butler, Ramezan Jafari, Roghayeh Badeli, Amirhossein Sahebkar
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and is potentially treatable, though there are few therapeutic agents available. Artichoke leaf extract (ALE) has shown potential as a hepatoprotective agent. This study sought to determine if ALE had therapeutic utility in patients with established NAFLD. In this randomized double-blind placebo-controlled parallel-group trial, 100 subjects with ultrasound-diagnosed NAFLD were randomized to either ALE 600 mg daily or placebo for a 2-month period...
March 9, 2018: Phytotherapy Research: PTR
Jennifer Y Chen, Yanjie Ren, Peng Yan, Morgan E Belina, Raymond T Chung, Adeel A Butt
Recent preclinical studies have suggested an antifibrotic role for tricyclic antidepressants. Using the Electronically Retrieved Cohort of HCV Infected Veterans, we aimed to evaluate the impact of TCA use on fibrosis progression and development of hepatocellular carcinoma (HCC) among HCV-infected persons. Subjects were categorized according to use of tricyclic antidepressants, selective serotonin reuptake inhibitors, or no antidepressants. tricyclic antidepressants or selective serotonin uptake inhibitors use was defined according to cumulative defined daily dose, and categories were mutually exclusive...
February 25, 2018: Journal of Viral Hepatitis
Ahmed Cordie, Ahmed Salama, Marwa El-Sharkawy, Saeed M El-Nahaas, Marwa Khairy, Aisha Elsharkawy, Mohamed Hassany, Gamal Esmat
BACKGROUND: Assessment of hepatic fibrosis in chronic hepatitis C virus patients by liver biopsy is not widely accepted despite its accuracy, being invasive, carrying complications and adding cost. This paved the way to development and use of non-invasive markers of fibrosis in diagnosis of hepatic fibrosis. AIM: Evaluating the efficiency of Fib-4, Egy-score, Aspartate-to-platelet ratio index (APRI) and Göteborg University Cirrhosis Index (GUCI) in comparison to liver biopsy, in the assessment of hepatic fibrosis in chronic hepatitis C patients Methods: Cross sectional study including 200 chronic HCV patients were divided into two groups according to stage of fibrosis (Metavir score) into non-significant fibrosis (<F2) and significant fibrosis (≥F2)...
February 24, 2018: Journal of Medical Virology
Dipendra Khadka, Sushil Prajapati, Sudhamshu Kc, Jeetendra Kaji Shrestha, Niyanta Karki, Bikash Jaishi, Kiran Regmi, Sandip Khadka
INTRODUCTION: Upper gastro-intestinal endoscopy remains the gold standard for screening for esophageal varices but it has its own limitations. It is an invasive, expensive and uncomfortable procedure and needs clinical expertise. Accordingly, this study was conducted to establish the role of non-invasive markers for prediction of esophageal varices in liver cirrhosis. METHODS: A hospital based descriptive cross-sectional study was carried out in Liver unit of National Academy of Medical Sciences, Bir Hospital, from October 2016 to September 2017...
October 2017: JNMA; Journal of the Nepal Medical Association
Zhongfeng Wang, Xu Liu, Hongqin Xu, Limei Qu, Dezhi Zhang, Pujun Gao
The aim of this study was to evaluate the ability of noninvasive markers to identify the histological severity of primary biliary cholangitis (PBC).Fifty-eight treatment-naïve PBC patients who had undergone liver biopsy were enrolled in our study. The patients' histological stages were based on the classifications of Ludwig and Scheuer. Aspartate aminotransferase-to-platelet ratio index (APRI), fibrosis index based on the 4 factors (FIB-4), red blood cell distribution width to platelet ratio (RPR), and platelet count to spleen thickness (PC/ST) ratio were calculated...
February 2018: Medicine (Baltimore)
Melissa Louise Kelly, Stephen M Riordan, Rohan Bopage, Andrew R Lloyd, Jeffrey John Post
INTRODUCTION: Achievement of the 2030 World Health Organisation (WHO) global hepatitis C virus (HCV) elimination targets will be underpinned by scale-up of testing and use of direct-acting antiviral treatments. In Australia, despite publically-funded testing and treatment, less than 15% of patients were treated in the first year of treatment access, highlighting the need for greater efficiency of health service delivery. To this end, non-invasive fibrosis algorithms were examined to reduce reliance on transient elastography (TE) which is currently utilised for the assessment of cirrhosis in most Australian clinical settings...
2018: PloS One
X-Z Yang, A-W Gen, J-C Xian, L Xiao
OBJECTIVE: Hepatic fibrosis is a repair response to chronic liver injury. This study evaluated the diagnostic value of various noninvasive indicators for hepatic fibrosis in patients with chronic liver disease. PATIENTS AND METHODS: 95 patients with liver biopsy were enrolled in this study. Routine clinical and laboratory examinations were collected, including age, sex, blood routine, biochemistry, serum fibrosis, and FibroTouch. APRI and FIB4 scores were calculated...
January 2018: European Review for Medical and Pharmacological Sciences
Xin-Min Xu, Xiao-Yang Zhou, Xiang-Yu Li, Jie Guo, Hui-Zhu Wang, Yue Li, Cheng-Cheng Yang, Teng-Hui Liu, Jian-Ping Cai
To evaluate the urinary levels of 8-oxo-7,8-dihydro-2'deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn) in liver injury patients with hepatitis B virus (HBV) infection and to explore the relationship between urinary 8-oxo-dGsn or 8-oxo-Gsn and degree of liver damage. We enrolled 138 liver injury patients with HBV infection and 169 age- and sex-matched healthy controls in this study. A sensitive and accurate isotope-diluted liquid chromatograph mass spectrometer/mass spectrometer (LC-MS/MS) method was used to measure the urinary levels of 8-oxo-Gsn and 8-oxo-dGsn...
February 27, 2018: Free Radical Research
Christopher Sung-Huan Yeh, Chao-Wei Hsu, Kung-Hao Liang, Yi-Cheng Chen, Chih-Lang Lin, Rong-Nan Chien, Tsung-Hui Hu, Wey-Ran Lin, Ming-Wei Lai, Yu-De Chu, Chau-Ting Yeh
BACKGROUND AND AIM: Commonly used non-invasive fibrosis scores usually included serum transaminase levels in the equations, including aspartate-to-platelet-ratio-index (APRI) and fibrosis-4 (FIB-4). Transaminases fluctuated significantly in chronic hepatitis B (CHB) patients with exacerbations, leading to unsteady score values. As such, here, we aim to develop a transaminase-free score suitable for pretherapeutic evaluation of fibrosis stages. METHODS: Firstly, 1082 treatment-naïve CHB patients were enrolled and divided into modeling (n = 541) and verification (n = 541) cohorts...
February 8, 2018: Journal of Gastroenterology and Hepatology
Mohammed Tag-Adeen, Maha Zeinelabedin Omar, Fatma Mohamed Abd-Elsalam, Ali Hasaneen, Mohamed Ahmed Mohamed, Hala Mohamed Elfeky, Ebada Mohamed Said, Badawy Abdul-Aziz, Amira Hefney Osman, Enas Sebaey Ahmed, Ghada Sidky Osman, Taghreed Abdul-Samie
Fibrosis assessment in chronic hepatitis B (CHB) is essential for prediction of long-term prognosis and proper treatment decision. This study was conducted to assess predictability of 5 simple noninvasive fibrosis indexes in comparison to liver biopsy in CHB patients.A total of 200 CHB adult Egyptian patients were consecutively included in this study, all were subjected to liver biopsy with staging of fibrosis using METAVIR scoring system. Fibrosis indexes including S-index, red cell distribution width to platelets ratio index (RPR), fibrosis-4 index (Fib-4), AST to platelets ratio index (APRI), and AST/ALT ratio index (AAR) were compared to biopsy result and their predictabilities for the different fibrosis stages were assessed using area under receiver operating characteristic curve (AUROC) analysis...
February 2018: Medicine (Baltimore)
Zaixing Yang, Yan Liang, Feng Lin, Zhencheng Zhang, Wanwan Luo, Yuting Zhang, Renqian Zhong
BACKGROUND: Stromal cell-derived factor-1 (SDF-1), also called chemokine (C-X-C motif) ligand 12 (CXCL12), as a chemokine for premature B cells, T cells and monocytes, is detected in liver, pancreas, spleen and heart. However, its diagnostic value for primary biliary cholangitis (PBC) as well as the association of SDF-1 with inflammatory and fibrotic progression is unclear. The aim of this study was to determine serum stromal cell-derived factor-1 (SDF-1) level and to explore its diagnostic value for primary biliary cholangitis (PBC) as well as the association of SDF-1 with inflammatory and fibrotic progression of PBC...
February 2, 2018: International Immunopharmacology
Andrea Dória Batista, Carlos Jonnatan Pimentel Barros, Tássia Brena Barroso Carneiro Costa, Michele Maria Gonçalves de Godoy, Ronaldo Dionísio Silva, Joelma Carvalho Santos, Mariana Montenegro de Melo Lira, Norma Thomé Jucá, Edmundo Pessoa de Almeida Lopes, Ricardo Oliveira Silva
AIM: To develop metabonomic models (MMs), using 1 H nuclear magnetic resonance (NMR) spectra of serum, to predict significant liver fibrosis (SF: Metavir ≥ F2), advanced liver fibrosis (AF: METAVIR ≥ F3) and cirrhosis (C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C (CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4). METHODS: Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included...
January 27, 2018: World Journal of Hepatology
Jing Li, Ri-Cheng Mao, Xiao-Ling Li, Jin-Wei Zheng, Xun Qi, Quan Yuan, Jun Zhang, Ji-Ming Zhang, Ning-Shao Xia
BACKGROUNDS: The evaluation of liver fibrosis stages is essential for the clinical management of chronic hepatitis B (CHB). AIMS: To develop and validate a novel noninvasive index for moderate to severe fibrosis (≥S2) in CHB patients. METHODS: A total of 401 CHB patients who underwent liver biopsy were divided into the training (n = 300) and validation (n = 101) cohort. Histological severity was scored using a modified Scheuer system...
January 5, 2018: Digestive and Liver Disease
Tiziana Vinciguerra, Andrea Brunati, Ezio David, Filomena Longo, Michele Pinon, Fulvio Ricceri, Luisa Castellino, Antonio Piga, Maria Teresa Giraudo, Francesco Tandoi, Fabio Cisarò, Dominic Dell Olio, Giuseppe Isolato, Renato Romagnoli, Mauro Salizzoni, Pier Luigi Calvo
As graft survival in pediatric LT is often affected by progressive fibrosis, numerous centers carry out protocol liver biopsies. Follow-up biopsy protocols differ from center to center, but all biopsies are progressively spaced out, as time from transplant increases. Therefore, there is a need for non-invasive techniques to evaluate graft fibrosis progression in those children who have no clinical or serological signs of liver damage. Indirect markers, such as the APRI, should be relied on with caution because their sensitivity in predicting fibrosis can be strongly influenced by the etiology of liver disease, severity of fibrosis, and patient age...
January 25, 2018: Pediatric Transplantation
Qiang Li, Liang Chen, Yu Zhou
Noninvasive fibrosis tests have been used widely for evaluation of liver fibrosis in patients with chronic hepatitis B (CHB). We aimed to investigate the influence of antiviral treatment on FibroScan, APRI, and FIB-4 in CHB patients with significant liver histological changes (SLHC) defined as inflammatory grade ≥ A2 and/or fibrosis stage ≥ F2. A total of 104 CHB patients with SLHC at the baseline were included. FibroScan, APRI, and FIB-4 values were compared before and after 3-year entecavir (ETV) treatment...
January 19, 2018: Clinical and Experimental Medicine
Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Yi-You Chiou, Chien-Wei Su, Yun-Hsuan Lee, Yi-Hsiang Huang, Fa-Yauh Lee, Ming-Chih Hou, Teh-Ia Huo
Liver functional capacity is a crucial survival determinant for hepatocellular carcinoma (HCC). Noninvasive models were proposed to assess hepatic reserve, but their performance in outcome prediction is unclear. We aimed to investigate 10 currently used liver function models in HCC patients undergoing radiofrequency ablation (RFA). A total 499 HCC patients were prospectively identified. Homogeneity and corrected Akaike information criteria (AICc) were compared. Cox proportional hazards model was used to identify independent survival predictors...
January 16, 2018: Scientific Reports
Jennifer H Benbow, April D Elam, Krista L Bossi, Danae L Massengill, Elizabeth Brandon-Warner, William E Anderson, Catherine R Culberson, Mark W Russo, Andrew S deLemos, Laura W Schrum
BACKGROUND AND AIM: Hepatitis C virus (HCV)-related cirrhosis, one of the most common etiologies of liver cirrhosis in the Western world, is a risk factor for hepatocellular carcinoma. To confirm and improve current effectiveness of screening and prognosis of patients with established cirrhosis, a credible, simple plasma biomarker is needed. Hepatic stellate cell activation, a pivotal event in cirrhosis development, results in increased secretion of extracellular matrix proteins, including tenascin-C (TnC)...
March 2018: Digestive Diseases and Sciences
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