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https://www.readbyqxmd.com/read/29350286/changes-of-fibroscan-apri-and-fib-4-in-chronic-hepatitis-b-patients-with-significant-liver-histological-changes-receiving-3-year-entecavir-therapy
#1
Qiang Li, Liang Chen, Yu Zhou
Noninvasive fibrosis tests have been used widely for evaluation of liver fibrosis in patients with chronic hepatitis B (CHB). We aimed to investigate the influence of antiviral treatment on FibroScan, APRI, and FIB-4 in CHB patients with significant liver histological changes (SLHC) defined as inflammatory grade ≥ A2 and/or fibrosis stage ≥ F2. A total of 104 CHB patients with SLHC at the baseline were included. FibroScan, APRI, and FIB-4 values were compared before and after 3-year entecavir (ETV) treatment...
January 19, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29339752/prognostic-performance-of-ten-liver-function-models-in-patients-with-hepatocellular-carcinoma-undergoing-radiofrequency-ablation
#2
Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Yi-You Chiou, Chien-Wei Su, Yun-Hsuan Lee, Yi-Hsiang Huang, Fa-Yauh Lee, Ming-Chih Hou, Teh-Ia Huo
Liver functional capacity is a crucial survival determinant for hepatocellular carcinoma (HCC). Noninvasive models were proposed to assess hepatic reserve, but their performance in outcome prediction is unclear. We aimed to investigate 10 currently used liver function models in HCC patients undergoing radiofrequency ablation (RFA). A total 499 HCC patients were prospectively identified. Homogeneity and corrected Akaike information criteria (AICc) were compared. Cox proportional hazards model was used to identify independent survival predictors...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330728/analysis-of-plasma-tenascin-c-in-post-hcv-cirrhosis-a-prospective-study
#3
Jennifer H Benbow, April D Elam, Krista L Bossi, Danae L Massengill, Elizabeth Brandon-Warner, William E Anderson, Catherine R Culberson, Mark W Russo, Andrew S deLemos, Laura W Schrum
BACKGROUND AND AIM: Hepatitis C virus (HCV)-related cirrhosis, one of the most common etiologies of liver cirrhosis in the Western world, is a risk factor for hepatocellular carcinoma. To confirm and improve current effectiveness of screening and prognosis of patients with established cirrhosis, a credible, simple plasma biomarker is needed. Hepatic stellate cell activation, a pivotal event in cirrhosis development, results in increased secretion of extracellular matrix proteins, including tenascin-C (TnC)...
January 12, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29324587/linkage-to-care-of-hbsag-positive-and-anti-hcv-positive-patients-after-a-systematic-screening-approach-in-the-german-primary-care-setting
#4
Anja Lüllau, David Petroff, Olaf Bätz, Jan Kramer, Katrin Jedrysiak, Hannelore Tenckhoff, Thomas Berg, Ingmar Wolffram, Johannes Wiegand
BACKGROUND: Identification of previously unknown cases is important to lower the burden of chronic hepatitis B and C infection. However, a screening program in the primary care setting has not yet been established. Therefore, a systematic screening project was conducted in 21 008 patients (Wolffram and colleagues). Here, we describe linkage to care of identified HbsAg-positive and anti-hepatitis C virus (HCV)-positive patients. METHODS: General practitioners characterized further medical care by a standardized questionnaire...
January 10, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29320552/first-report-of-occult-hepatitis-b-infection-among-art-na%C3%A3-ve-hiv-seropositive-individuals-in-maputo-mozambique
#5
Awa Abdul Carimo, Eduardo Samo Gudo, Cremildo Maueia, Nédio Mabunda, Lúcia Chambal, Adolfo Vubil, Ana Flora, Francisco Antunes, Nilesh Bhatt
BACKGROUND: The prevalence of hepatitis B virus (HBV) infection and human immunodeficiency virus (HIV) infection in Mozambique is one of the highest in the world, though in spite of this the prevalence of occult hepatitis B infection (OBI) is unknown. OBJECTIVES: This study was conducted with the aim to investigate the prevalence of OBI and frequency of isolated hepatitis B core antibody (anti-HBc alone) among antiretroviral (ART) naïve HIV-positive patients in Mozambique...
2018: PloS One
https://www.readbyqxmd.com/read/29318450/the-utility-of-noninvasive-scores-in-assessing-the-prevalence-of-nonalcoholic-fatty-liver-disease-and-advanced-fibrosis-in-type-1-diabetic-patients
#6
Amandeep Singh, Phuc Le, Rocio Lopez, Naim Alkhouri
GOALS: The aim of our study is to assess the prevalence of nonalcoholic fatty liver disease (NAFLD) and advanced hepatic fibrosis in patients with type 1 diabetes (T1D) using simple noninvasive scores. BACKGROUND: There is paucity of data on the prevalence of NAFLD in T1D. Moreover, T1D could be a risk factor for advanced disease in NAFLD patients. STUDY: Using ICD-9 codes, all patients with the diagnosis of T1D were reviewed and a retrospective chart analysis was carried out on 23,314 patients between the ages of 18 and 80...
January 9, 2018: Hepatology International
https://www.readbyqxmd.com/read/29315684/a-novel-predictor-of-severe-dengue-the-aspartate-aminotransferase-platelet-count-ratio-index-apri
#7
Zhang Hao, Xie Zhiwei, Xie Xushuo, Ou Yingyan, Zeng Wenting, Zhou Yuanping
OBJECTIVE: To evaluate risk factors for the development of dengue into severe dengue in Guangdong. METHODS: A retrospective analysis of clinical data from 212 dengue patients between June and October 2014. RESULTS: 174 (82.1%) patients in our study had classic dengue, of which 38 (17.9%) had severe diseases. The frequencies of jaundice, pleural effusion, ascites and vaginal bleeding were significantly different between the two groups (p < 0...
January 5, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29315641/novel-scores-combining-afp-with-non-invasive-markers-for-prediction-of-liver-fibrosis-in-chronic-hepatitis-c-patients
#8
Mohamed Gamil, Mohamed Alboraie, Mohammad El-Sayed, Aisha Elsharkawy, Noha Asem, Tamer Elbaz, Mohammad Mohey, Bahaa Abbas, Mai Mehrez, Gamal Esmat
BACKGROUND: Serum levels of alpha-fetoprotein (AFP) were reported to increase in patients with significant or advanced hepatic fibrosis. Combination of non-invasive tests decreases the use of liver biopsy in large proportion of chronic HCV patients. AIM: To compare and combine AFP with commonly used non-invasive fibrosis tests in novel scores for prediction of different stages of hepatic fibrosis. PATIENTS AND METHODS: Six hundred and fifty two treatment naïve chronic hepatitis C patients were enrolled...
January 6, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29314613/validation-and-comparison-of-seventeen-noninvasive-models-for-evaluating-liver-fibrosis-in-chinese-hepatitis-b-patients
#9
Minhui Dong, Jingwen Wu, Xueping Yu, Jing Li, Sisi Yang, Xun Qi, Richeng Mao, Yongmei Zhang, Jie Yu, Haoxiang Zhu, Feifei Yang, Yanli Qin, Jiming Zhang
BACKGROUND & AIMS: To avoid liver biopsy, many noninvasive models comprised of serum markers for liver fibrosis assessment have been developed. Given that most of them were developed in hepatitis C cohorts and few of them have been validated in Chinese hepatitis B patients, we aim to conduct this validation and compare their diagnostic accuracies in such a population. METHODS: A total of 937 HBV infected patients who underwent liver biopsy were included in this single-center retrospective study...
January 3, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29311616/yield-and-resource-use-efficiency-of-plukenetia-volubilis-plants-at-two-distinct-growth-stages-as-affected-by-irrigation-and-fertilization
#10
He-De Gong, Yan-Jing Geng, Chun Yang, Dong-Ying Jiao, Liang Chen, Zhi-Quan Cai
This study is to test how seedlings (vegetative) and large plants (reproductive) of an oilseed crop (Plukenetia volubilis) responded to regulated deficit irrigation techniques (conventional deficit irrigation, DI; alternative partial root-zone irrigation, APRI) in a tropical humid monsoon area. Seedlings were more sensitive to water deficit than large plants. Although APRI did better than DI in saving water for both seedlings and large plants at the same amount of irrigation, full irrigation (FI) is optimal for faster seedling growth at the expense of water-use efficiency (WUE)...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29279441/data-mining-machine-learning-algorithms-using-il28b-genotype-and-biochemical-markers-best-predicted-advanced-liver-fibrosis-in-chronic-hcv
#11
Hend Ibrahim Shousha, Abubakr Hussein Awad, Dalia Abdelhamid Omran, Mayada Mohamed Elnegouly, Mahasen Mabrouk
  IL28 single nucleotide polymorphism (rs12979860) is an aetiology-independent predictor of hepatitis C virus (HCV) related hepatic fibrosis. Data mining is a method of predictive analysis which can explore tremendous volumes of information found in health records to discover hidden patterns and relationships. The study aims to evaluate and compare the prediction accuracy of APRI, FIB-4 versus data mining for prediction of HCV related advanced fibrosis. This retrospective study included 427 patients with chronic HCV...
December 26, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29251384/aspartate-transaminase-to-platelet-ratio-index-and-gamma-glutamyl-transpeptidase-to-platelet-ratio-outweigh-fibrosis-index-based-on-four-factors-and-red-cell-distribution-width-platelet-ratio-in-diagnosing-liver-fibrosis-and-inflammation-in-chronic-hepatitis
#12
Xiaojuan Wu, Bei Cai, Zhenzhen Su, Yamei Li, Jin Xu, Rong Deng, Lanlan Wang
BACKGROUND: The benefits of using serum markers to diagnose stages of liver disease in chronic hepatitis B (CHB) patients are controversial. We conducted a study to compare the clinical significance of four markers in evaluating liver inflammation and fibrosis in CHB patients. METHODS: A total of 323 treatment-naive CHB patients who received a liver biopsy and routine laboratory testing were enrolled in our study. We used the Scheuer scoring system as a pathological standard for diagnosing liver inflammation and fibrosis...
December 18, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29244873/fatty-acids-in-non-alcoholic-steatohepatitis-focus-on-pentadecanoic-acid
#13
Wonbeak Yoo, Donjeta Gjuka, Heather L Stevenson, Xiaoling Song, Hong Shen, Suk Young Yoo, Jing Wang, Michael Fallon, George N Ioannou, Stephen A Harrison, Laura Beretta
Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease and ranges from isolated steatosis to NASH. To determine whether circulating fatty acids could serve as diagnostic markers of NAFLD severity and whether specific fatty acids could contribute to the pathogenesis of NASH, we analyzed two independent NAFLD patient cohorts and used the methionine- and choline-deficient diet (MCD) NASH mouse model. We identified six fatty acids that could serve as non-invasive markers of NASH in patients with NAFLD...
2017: PloS One
https://www.readbyqxmd.com/read/29235488/nomogram-for-cirrhosis-in-patients-with-chronic-hepatitis-b-a-simple-self-assessed-scale-for-individual-risk-of-cirrhosis
#14
Zhiqiao Zhang, Jing Li, Peng Wang, Tingshan He, Yanling Ouyang, Yiyan Huang
The aim of this retrospective study was to establish a simple self-assessed scale for individual risk of cirrhosis in patients with chronic hepatitis B. A total of 1808 consecutive patients were enrolled and analyzed. According to the results of multivariate logistic regression analysis, a simple nomogram was calculated for cirrhosis. The area under receiver operating characteristic curves (AUROCs) were calculated to compare the diagnostic accuracy of nomogram with aspartate aminotransferase to platelet ratio index (APRI), fibrosis index based on the four factors (FIB-4), and S index...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29231188/major-hepatic-complications-in-ursodeoxycholic-acid-treated-patients-with-primary-biliary-cholangitis-risk-factors-and-time-trends-in-incidence-and-outcome
#15
Maren H Harms, Willem J Lammers, Douglas Thorburn, Christophe Corpechot, Pietro Invernizzi, Harry L A Janssen, Pier M Battezzati, Frederik Nevens, Keith D Lindor, Annarosa Floreani, Cyriel Y Ponsioen, Marlyn J Mayo, George N Dalekos, Tony Bruns, Albert Parés, Andrew L Mason, Xavier Verhelst, Kris V Kowdley, Jorn C Goet, Gideon M Hirschfield, Bettina E Hansen, Henk R van Buuren
OBJECTIVES: In this era of near universal ursodeoxycholic acid (UDCA) treatment for primary biliary cholangitis (PBC), progression to cirrhosis still occurs in an important proportion of patients. The aim of this study was to describe the incidence of cirrhosis-associated complications in patients with PBC and assess risk factors and impact on survival. METHODS: Cohorts of UDCA-treated patients from 16 European and North-American liver centers were included. We used Cox proportional hazards assumptions and Kaplan-Meier estimates...
December 12, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29230907/comparative-evaluation-of-gpr-versus-apri-and-fib-4-in-predicting-different-levels-of-liver-fibrosis-of-chronic-hepatitis-b
#16
D-P Liu, W Lu, Z-Q Zhang, Y-B Wang, R-R Ding, X-L Zhou, D Huang, X-F Li
It is of great significance to develop and evaluate noninvasive indexes predicting the level of liver fibrosis. The aim of this study was to comparatively evaluate gamma-glutamyl transpeptidase-to-platelet ratio (GPR) versus aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis index based on 4 factors (FIB-4) in predicting different levels of liver fibrosis of chronic hepatitis B (CHB) within the framework of HBeAg-positive and HBeAg-negative patients. A total of 1157 HBeAg-positive and 859 HBeAg-negative CHB patients were enrolled, among whom the pathological stage ≥S2, ≥S3, ≥S4 were defined as significant fibrosis, extensive fibrosis and cirrhosis, respectively...
December 12, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29226638/reference-values-of-certain-serum-indicators-of-liver-fibrosis
#17
Blagovesta Pencheva, Rossen Mihajlov, Adelaida Ruseva, Rumyana Mitova, Kaloyan Petrov, Gergana Taneva, Jordan Genov
BACKGROUND: Liver fibrosis shows a continuously increasing trend worldwide, due to alcohol abuse, obesity, and, to a lesser extent, chronic hepatitis B and C. Biopsy is still considered the "gold standard" for diagnosis of liver fibrosis. However, it has a number of limitations, such as invasiveness, high cost, need for specialists to conduct and interpret biopsy results, risk of complications, inability to dynamically monitor the pathological process, low patient compliance, and uneven fibrosis distribution...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29226524/the-usefulness-of-virtual-touch-quantification-for-staging-liver-fibrosis-in-patients-with-hepatitis-c-and-the-factors-affecting-liver-stiffness-measurement-failure-compared-with-liver-biopsy
#18
Natsumi Tsukano, Shiho Miyase, Tatsuhiko Saeki, Keiko Mizobe, Hirofumi Iwashita, Nobuyuki Arima, Shigetoshi Fujiyama
AIM: Assessing liver fibrosis in patients with hepatitis C is important to predict carcinogenesis. In this study, we evaluated the usefulness of virtual touch quantification (VTQ) for staging liver fibrosis, and investigated factors causing the discrepancy between the estimated fibrosis stage using VTQ and the pathological fibrosis stage. METHODS: Patients with hepatitis C (n=302) were assessed using VTQ and underwent pathological liver investigation within 1 week before and after VTQ...
December 11, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29215435/noninvasive-fibrosis-markers-and-chronic-kidney-disease-among-adults-with-nonalcoholic-fatty-liver-in-usa
#19
Karn Wijarnpreecha, Charat Thongprayoon, Melissa Scribani, Patompong Ungprasert, Wisit Cheungpasitporn
BACKGROUND/AIMS: Studies have shown that nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of chronic kidney disease (CKD). However, it is unknown whether severe liver fibrosis is associated with a higher prevalence of CKD among NAFLD. We examined the diagnostic performance of noninvasive fibrosis markers in identifying prevalent CKD among NAFLD. METHODS: This study represents an analysis of the National Health and Nutrition Examination Survey conducted in the USA between 1988 and 1994...
December 5, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29209127/prediction-of-hepatocellular-carcinoma-development-by-aminotransferase-to-platelet-ratio-index-in-primary-biliary-cholangitis
#20
Ka-Shing Cheung, Wai-Kay Seto, James Fung, Lung-Yi Mak, Ching-Lung Lai, Man-Fung Yuen
AIM: To investigate the usefulness of aspartate aminotransferase to platelet ratio index (APRI) in predicting hepatocellular carcinoma (HCC) risk in primary biliary cholangitis (PBC). METHODS: We identified PBC patients between 2000 and 2015 by searching the electronic medical database of a tertiary center. The hazard ratio (HR) of HCC with different risk factors was determined by Cox proportional hazards model. RESULTS: One hundred and forty-four PBC patients were recruited...
November 28, 2017: World Journal of Gastroenterology: WJG
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