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https://www.readbyqxmd.com/read/28938634/a-novel-predictive-model-using-routinely-clinical-parameters-to-predict-liver-fibrosis-in-patients-with-chronic-hepatitis-b
#1
Jian Wang, Xiaomin Yan, Yue Yang, Haiyan Chang, Bei Jia, Xiang-An Zhao, Guangmei Chen, Juan Xia, Yong Liu, Yuxin Chen, Guiyang Wang, Li Wang, Zhaoping Zhang, Weimao Ding, Rui Huang, Chao Wu
OBJECTIVES: Noninvasive models have been established for the assessment of liver fibrosis in patients with chronic hepatitis B(CHB). However, the predictive performance of these established models remains inconclusive. We aimed to develop a novel predictive model for liver fibrosis in CHB based on routinely clinical parameters. RESULTS: Platelets(PLT), the standard deviation of red blood cell distribution width(RDW-SD), alkaline phosphatase(ALP) and globulin were independent predictors of significant fibrosis by multivariable analysis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938582/effect-of-hepatic-steatosis-on-the-progression-of-chronic-hepatitis-b-a-prospective-cohort-and-in-vitro-study
#2
Yangqin Chen, Chunlei Fan, Yuhan Chen, Hui Liu, Shanshan Wang, Peiling Dong, Lei Li, Huiguo Ding
AIM: To characterize the effect of hepatic steatosis (HS) on the progression of chronic hepatitis B. METHODS: A total of 162 chronic hepatitis B (CHB) patients confirmed by liver biopsy were involved in this study. All subjects were prospectively followed-up for 5 years in real-life clinical practice. Fibrosis stage was determined using aspartate aminotransferase-to-platelet ratio index (APRI). The end-point was cirrhosis, liver cancer or death. The effects of steatosis on the biological behavior of hepatocellular carcinoma cells were investigated using oleic acid-induced lipid accumulation in HepG2, HLE, PLC, and SMMC-7721 cells...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28931062/factors-associated-with-hepatitis-c-prevalence-differ-by-the-stage-of-liver-fibrosis-a-cross-sectional-study-in-the-general-population-in-poland-2012-2016
#3
Magdalena Rosińska, Natalia Parda, Agnieszka Kołakowska, Paulina Godzik, Karolina Zakrzewska, Kazimierz Madaliński, Andrzej Zieliński, Anna Boguradzka, Rafał Gierczyński, Małgorzata Stępień
BACKGROUND & AIMS: There is a considerable burden of hepatitis C in Europe related to the lack of prompt diagnosis. We aimed to estimate the prevalence and related risk factors of HCV infections by the stages of liver fibrosis, using non-invasive methods, to understand testing needs in Poland. METHODS: A cross-sectional study was conducted in 2012-2016 adopting a stratified random sampling of primary health care units followed by systematic sampling of patients within each unit...
2017: PloS One
https://www.readbyqxmd.com/read/28922440/real-life-use-of-3-direct-acting-antiviral-regimen-in-a-large-cohort-of-patients-with-genotype-1b-hcv-compensated-cirrhosis
#4
Liana Gheorghe, Speranta Iacob, Manuela Curescu, Ciprian Brisc, Cristina Cijevschi, Florin Caruntu, Carol Stanciu, Iulia Simionov, Ioan Sporea, Cristian Gheorghe, Razvan Iacob, Victoria Arama, Roxana Sirli, Anca Trifan
BACKGROUND AND AIMS: Ombitasvir/Paritaprevir/ritonavir/Dasabuvir (OBV/PTV/r+DSV) is one of the elective direct-acting antivirals (DAAs) recommended by international guidelines and the only one covered by the National Insurance System in Romania until November 2016. Our aim was to present the first prospective Romanian cohort evaluating the effectiveness and safety in clinical practice of this 3DAA combination in patients with HCV genotype-1b Child A liver cirrhosis. METHODS: 681 patients received OBV/PTV/r+DSV+RBV for 12 weeks and were assessed clinically and biologically at baseline, week 4, 8, 12 (end of treatment, EOT), and 12 weeks after therapy (sustained viral response, SVR)...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28914448/significant-burden-of-nonalcoholic-fatty-liver-disease-with-advanced-fibrosis-in-the-us-a-cross-sectional-analysis-of-2011-2014-national-health-and-nutrition-examination-survey
#5
R J Wong, B Liu, T Bhuket
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease in the US. Understanding the epidemiology of NAFLD, with specific focus on individuals with hepatic fibrosis is important to guide healthcare resource planning. AIM: To evaluate prevalence and predictors of hepatic fibrosis among US adults with NAFLD. METHODS: We performed a cross-sectional study using data from the updated 2011-2014 National Health and Nutrition Examination Survey, a national, stratified, multistage sampling survey of non-institutionalised US adults age ≥ 20...
September 15, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28902848/the-effect-of-hiv-infection-and-hcv-viremia-on-inflammatory-mediators-and-hepatic-injury-the-women-s-interagency-hiv-study
#6
Sheila M Keating, Jennifer L Dodge, Philip J Norris, John Heitman, Stephen J Gange, Audrey L French, Marshall J Glesby, Brian R Edlin, Patricia S Latham, Maria C Villacres, Ruth M Greenblatt, Marion G Peters
Hepatitis C virus infection induces inflammation and while it is believed that HIV co-infection enhances this response, HIV control may reduce inflammation and liver fibrosis in resolved or viremic HCV infection. Measurement of systemic biomarkers in co-infection could help define the mechanism of inflammation on fibrosis and determine if HIV control reduces liver pathology. A nested case-control study was performed to explore the relationship of systemic biomarkers of inflammation with liver fibrosis in HCV viremic and/or seropositive women with and without HIV infection...
2017: PloS One
https://www.readbyqxmd.com/read/28885276/performance-of-simple-noninvasive-scoring-systems-for-the-prediction-of-advanced-fibrosis-in-patients-with-chronic-hepatitis-b
#7
Sonja Lang, Fabian Kütting, Agnes Staub, Jessica Schramowski, Christoph Schramm, Philipp Kasper, Tobias Goeser, Hans-Michael Steffen, Münevver Demir
BACKGROUND AND AIM: The aim of the study was to analyze the diagnostic performance and clinical utility of simple noninvasive tests for the detection of advanced fibrosis in patients with chronic hepatitis B (CHB) infection seen at a tertiary referral center in Germany. PATIENTS AND METHODS: We retrospectively analyzed 239 adult CHB patients with available liver biopsies. Patient demographics, hepatitis B markers, antiviral treatment, laboratory parameters, results from liver imaging, and histology were recorded...
September 6, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28884309/globulin-platelet-model-predicts-significant-fibrosis-and-cirrhosis-in-chb-patients-with-high-hbv-dna-and-mildly-elevated-alanine-transaminase-levels
#8
Qiang Li, Chuan Lu, Weixia Li, Yuxian Huang, Liang Chen
The globulin-platelet model (GP) is a new noninvasive liver fibrosis model developed in chronic hepatitis B (CHB) patients. This study aimed to evaluate the diagnostic performance of GP model for liver fibrosis and cirrhosis in CHB patients with high HBV DNA and mildly elevated alanine transaminase (ALT) levels. We enrolled 316 CHB patients with HBV DNA ≥ 4 log 10 copies/mL and 40 IU/L < ALT ≤ 80 IU/L. The GP, aspartate transaminase-to-platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4) were calculated...
September 7, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/28883700/diagnostic-value-of-fib-4-aspartate-aminotransferase-to-platelet-ratio-index-and-liver-stiffness-measurement-in-hepatitis-b-virus-infected-patients-with-persistently-normal-alanine-aminotransferase
#9
You-Wen Tan, Xing-Bei Zhou, Yun Ye, Cong He, Guo-Hong Ge
AIM: To assess the diagnostic value of FIB-4, aspartate aminotransferase-to-platelet ratio index (APRI), and liver stiffness measurement (LSM) in patients with hepatitis B virus infection who have persistently normal alanine transaminase (PNALT). METHODS: We enrolled 245 patients with chronic hepatitis B: 95 in PNALT group, 86 in intermittently elevated alanine transaminase (PIALT1) group [alanine transaminase (ALT) within 1-2 × upper limit of normal value (ULN)], and 64 in PIALT2 group (ALT > 2 × ULN)...
August 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28883388/retrospective-clinical-study-of-the-effects-of-t-tube-placement-for-bile-duct-stricture
#10
İbrahim Tayfun Şahiner, Murat Kendirci
BACKGROUND T-tube placement in the common bile duct (CBD) is a surgical alternative to bile duct reconstruction in cholecystectomy for cholecysto-choledocholithiasis, or gallstones. The aim of this retrospective clinical study was to investigate the incidence of late complications of T-tube placement. MATERIAL AND METHODS Retrospective review identified 35 patients who had T-tube placement during cholecystectomy. Clinical data were collected on surgical indications, patient demographics, and clinical symptoms...
September 8, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28851259/does-transient-elastography-correlate-with-liver-fibrosis-in-patients-with-psc-laennec-score-based-analysis-of-explanted-livers
#11
Marcin Krawczyk, Joanna Ligocka, Mariusz Ligocki, Joanna Raszeja-Wyszomirska, Małgorzata Milkiewicz, Grzegorz Szparecki, Tomasz Ilczuk, Barbara Górnicka, Krzysztof Zieniewicz, Marek Krawczyk, Frank Lammert, Piotr Milkiewicz
BACKGROUND AND AIMS: Previous studies demonstrated a close correlation between transient elastography (TE) and liver histology in chronic liver diseases. Data on the accuracy of TE in primary sclerosing cholangitis (PSC) remains scarce. Here, we investigated the association between TE, serum marker of liver injury and histology of explanted livers in PSC patients. METHODS: Thirty patients were prospectively recruited. TE (Fibroscan(®)) and blood sampling were performed during evaluation for liver transplantation (LT); the second blood sampling was performed on the day of LT...
August 29, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28844464/non-invasive-assessment-of-liver-fibrosis-with-elastpq-comparison-with-transient-elastography-and-serologic-fibrosis-marker-tests-and-correlation-with-liver-pathology-results
#12
Jeong Eun Lee, Kyung Sook Shin, June-Sik Cho, Sun Kyoung You, Ji Hye Min, Kyung-Hee Kim, In Sang Song, Kwang Sik Cheon
We investigated the feasibility of using ultrasound shear wave elastography point quantification (ElastPQ) for liver fibrosis staging and compared it with other non-invasive tools with respect to efficacy in liver stiffness measurement. A total of 106 patients who underwent liver stiffness measurements, using ElastPQ and biochemical investigations, before parenchymal liver biopsy or surgery were included. Among these, 51 also underwent transient elastography (TE). Correlations of ElastPQ, TE and aspartate aminotransferase-to-platelet ratio index (APRI) with histopathological findings (as the reference standard) were determined using Spearman's correlation coefficient...
November 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28841822/diminished-accuracy-of-biomarkers-of-fibrosis-in-low-replicative-chronic-hepatitis-b
#13
Faisal M Sanai, Taha Farah, Khalid Albeladi, Faisal Batwa, Yaser Dahlan, Mohammed A Babatin, Hamad Al-Ashgar, Hadeel AlMana, Khaled S Alsaad, Khalid AlSwat, Abdulrahman Aljumah, Ibrahim H AlTraif, Bahaa E Kailani, Khalid I Bzeizi
BACKGROUND: We evaluated the diagnostic accuracy of aspartate aminotransferase (AST)-to-platelet ratio index (APRI), fibrosis-4 index (FIB-4), AST/alanine aminotransferase (ALT) ratio (AAR), and age-platelet index (API) for significant fibrosis (Metavir F2-4) in low-replicative (HBV DNA <20,000 IU/mL) chronic hepatitis B virus (HBV) patients. METHODS: The sensitivity, specificity, and area under the receiver-operating characteristic curve (AUROC) of HBeAg-negative, low-replicative (n = 213) and high-replicative (HBV DNA ≥20,000 IU/mL, n = 153) patients was assessed...
August 25, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28840521/utility-of-serum-inflammatory-markers-for-predicting-microvascular-invasion-and-survival-for-patients-with-hepatocellular-carcinoma
#14
Jian Zheng, Ken Seier, Mithat Gonen, Vinod P Balachandran, T Peter Kingham, Michael I D'Angelica, Peter J Allen, William R Jarnagin, Ronald P DeMatteo
BACKGROUND: Preoperative serum inflammatory markers have been correlated with outcome after resection of hepatocellular carcinoma (HCC), but studies have had conflicting results. This study aimed to evaluate the association of six inflammatory markers with recurrence-free survival (RFS), overall survival (OS), and microvascular invasion (MVI), a well-known prognostic factor. METHODS: This study investigated 370 patients who underwent resection of HCC from 1992 to 2016, retrospectively evaluating their inflammatory indices and individual components including their neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), prognostic nutritional index (PNI), aspartate aminotransferase-to-platelet ratio index (APRI), and aspartate aminotransferase-to-neutrophil ratio index (ANRI)...
August 24, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28839517/serum-cholinesterase-a-predictive-biomarker-of-hepatic-reserves-in-chronic-hepatitis-d
#15
Minaam Abbas, Zaigham Abbas
AIM: To determine the predictive performance of cholinesterase compared to existing prognostic models in evaluating liver function in patients with chronic hepatitis D. METHODS: In an observational, cross-sectional and retrospective study, consecutive patients with hepatitis D cirrhosis were evaluated. Demographic, clinical and laboratory parameters were recorded. Serum cholinesterase levels were correlated with existing scoring models for chronic liver disease and Liver function tests...
August 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28831282/gamma-glutamyl-transpeptidase-to-platelet-ratio-predicts-significant-liver-fibrosis-of-chronic-hepatitis-b-patients-in-china
#16
Tianyi Ren, Huan Wang, Ruihong Wu, Junqi Niu
BACKGROUND AND AIMS: We want to investigate whether a novel noninvasive marker is suitable for Chinese CHB patients. METHODS: A total of 160 treatment-naïve CHB patients who underwent liver biopsy were enrolled in our study, and we assessed the diagnostic accuracies of GPR, aspartate transaminase-to-platelet ratio index (APRI), and the fibrosis index based on 4 factors (FIB-4) in them. RESULTS: Of these 160 CHB patients, the numbers of F0, F1, F2, F3, and F4 are 34 (21...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28820885/diagnostic-efficacy-of-noninvasive-liver-fibrosis-indexes-in-predicting-portal-hypertension-in-patients-with-cirrhosis
#17
Le Wang, Yuemin Feng, Xiaowen Ma, Guangchuan Wang, Hao Wu, Xiaoyu Xie, Chunqing Zhang, Qiang Zhu
BACKGROUND: Recent data suggest that noninvasive liver fibrosis indexes could be useful for predicting esophageal varices (EV) in cirrhotic patients. However, thus far, the diagnostic efficacy of these indexes in predicting portal hypertension (PH) in cirrhotic patients has been poorly evaluated. AIMS: To evaluate the diagnostic efficacy of noninvasive liver fibrosis indexes in the diagnosis of PH. METHODS: A total of 238 cirrhotic patients underwent hepatic venous pressure gradient (HVPG) evaluation and relevant serum tests to analyze the variables associated with PH grade...
2017: PloS One
https://www.readbyqxmd.com/read/28819319/gamma-glutamyl-transpeptidase-to-platelet-ratio-is-not-superior-to-apri-fib-4-and-rpr-for-diagnosing-liver-fibrosis-in-chb-patients-in-china
#18
Rui Huang, Guiyang Wang, Chen Tian, Yong Liu, Bei Jia, Jian Wang, Yue Yang, Yang Li, Zhenhua Sun, Xiaomin Yan, Juan Xia, Yali Xiong, Peixin Song, Zhaoping Zhang, Weimao Ding, Chao Wu
The gamma-glutamyl transpeptidase to platelet ratio (GPR) is a novel index to estimate liver fibrosis in chronic hepatitis B (CHB). Few studies compared diagnostic accuracy of GPR with other non-invasive fibrosis tests based on blood parameters. We analyzed diagnostic values of GPR for detecting liver fibrosis and compared diagnostic performances of GPR with APRI (aspartate aminotransferase-to-platelet ratio index), FIB-4 (fibrosis index based on the four factors), NLR (neutrophil-to-lymphocyte ratio), AAR (aspartate aminotransferase/alanine aminotransferase ratio) and RPR (red cell distribution width-to-platelet ratio) in HBeAg positive CHB and HBeAg negative CHB...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28796410/steatosis-severity-affects-the-diagnostic-performances-of-noninvasive-fibrosis-tests-in-nonalcoholic-fatty-liver-disease
#19
Sae Kyung Joo, Won Kim, Donghee Kim, Jung Ho Kim, Sohee Oh, Kook Lae Lee, Mee Soo Chang, Yong Jin Jung, Young Ho So, Myoung Seok Lee, Jeong Mo Bae, Byeong Gwan Kim
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of heterogeneous metabolic subtypes. This study compared the diagnostic performances of noninvasive fibrosis tests in predicting advanced fibrosis among patients with NAFLD and examined the effects of the subgroups on their diagnostic performances. METHODS: Three hundred fifteen patients with biopsy-proven NAFLD were prospectively enrolled. Acoustic radiation force impulse imaging (ARFI) was performed to obtain liver stiffness measurements (LSMs)...
August 10, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28792861/predictive-value-of-the-aspartate-aminotransferase-to-platelet-ratio-index-for-parenteral-nutrition-associated-cholestasis-in-premature-infants-with-intestinal-perforation
#20
Kannikar Vongbhavit, Mark A Underwood
BACKGROUND: Parenteral nutrition-associated cholestasis (PNAC) is a major cause of morbidity and mortality in premature infants. Early predictors of PNAC would have clinical value. We sought to evaluate risk factors and liver function testing as predictors of PNAC in premature infants with intestinal perforation. METHODS: Medical records of infants with a gestational age <34 weeks, birth weight <2000 g, and intestinal perforation due to either necrotizing enterocolitis or spontaneous intestinal perforation were reviewed...
August 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
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