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https://www.readbyqxmd.com/read/28213624/oligometastatic-colorectal-cancer-is-single-site-bony-colorectal-metastasis-a-treatable-condition
#1
Noel Cassar, Adrian Ben Cresswell, Brendan Moran
INTRODUCTION: A potentially resectable bony metastasis in the context of oligometastatic colorectal cancer is uncommon. Bony metastases are usually considered a late event with poor prognosis and generally associated with liver and/or lung metastases. INDEX CASE: A previously healthy 33-year-old gentleman, with no family history of colorectal cancer, presented with rectal bleeding and at colonoscopy had a biopsy-proven adenocarcinoma of the rectum, 7 cm from the anal verge...
February 17, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28202430/vespro-an-individual-patient-data-prospective-meta-analysis-of-selective-internal-radiation-therapy-versus-sorafenib-for-advanced-locally-advanced-or-recurrent-hepatocellular-carcinoma-of-the-sarah-and-sirvenib-trials
#2
Val Gebski, Emma Gibbs, Mihir Gandhi, Gilles Chatellier, Aurelia Dinut, Helena Pereira, Pierce Kh Chow, Valérie Vilgrain
BACKGROUND: Untreated advanced hepatocellular carcinoma (HCC) has an overall poor prognosis. Currently there are 2 ongoing prospective randomized controlled trials that are evaluating the efficacy and safety of sorafenib and selective internal radiation therapy (SIRT) with yttrium-90 resin microspheres in patients with advanced HCC. The SorAfenib versus Radioembolisation in Advanced Hepatocellular carcinoma (SARAH; 459 patients) trial is being performed in Europe and the SIRt VErsus SorafeNIB (SIRveNIB; 360 patients) trial in the Asia Pacific region...
February 15, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28190843/application-of-internal-standard-method-for-several-3d-transition-metallic-elements-in-flame-atomic-absorption-spectrometry-using-a-multi-wavelength-high-resolution-spectrometer
#3
Yusuke Toya, Toshiko Itagaki, Kazuaki Wagatsuma
We investigated a simultaneous internal standard method in flame atomic absorption spectrometry (FAAS), in order to better the analytical precision of 3d-transition metals contained in steel materials. For this purpose, a new spectrometer system for FAAS, comprising a bright xenon lamp as the primary radiation source and a high-resolution Echelle monochromator, was employed to measure several absorption lines at a wavelength width of ca. 0.3 nm at the same time, which enables the absorbances of an analytical line and also an internal standard line to be estimated...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28177190/improving-patient-selection-for-selective-internal-radiation-therapy-of-intra-hepatic-cholangiocarcinoma-a-meta-regression-study
#4
Alessandro Cucchetti, Alberta Cappelli, Cristina Mosconi, Jian-Hong Zhong, Matteo Cescon, Antonio Daniele Pinna, Rita Golfieri
BACKGROUND & AIMS: Selective Internal Radiation Therapy (SIRT) is emerging as a potential therapy for unresectable intra-hepatic cholangiocarcinoma (iCCA), able to prolong life-expectancy. Aim of the study was to collect available literature, meta-analyze data and results and investigate sources of heterogeneity through a meta-regression approach, before suggesting SIRT as a valuable option. METHODS: A systematic review of studies published until 1 September 2016 in PubMed and Scopus databases was performed...
February 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28164066/giant-cell-tumor-developing-in-paget-s-disease-of-bone-a-case-report-with-review-of-literature
#5
Vivek Verma, Ajay Puri, Sanket Shah, Bharat Rekhi, Ashish Gulia
INTRODUCTION: Paget's disease of bone (PDB) is a disease of elderly characterized by disorganized bone remodeling. Development of secondary neoplasm in PDB is a known but rare phenomenon. Development of giant cell tumor in PDB (GCT-PDB) is extremely rare, and little is known about its etiopathogenesis and management. We present a case report of such a development with a review of the literature and the role of various new modalities of treatment available in the management of this rare condition...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28139424/the-impact-of-active-breathing-control-on-internal-mammary-lymph-node-coverage-and-normal-tissue-exposure-in-breast-cancer-patients-planned-for-left-sided-postmastectomy-radiation-therapy
#6
Aisling Barry, Kathy Rock, Claudio Sole, Mohammad Rahman, Melania Pintilie, Grace Lee, Anthony Fyles, C Anne Koch
PURPOSE: The purpose of this study was to evaluate the impact of the active breathing control (ABC) technique on IMN coverage and organs at risk in patients planned for postmastectomy radiation therapy (PMRT), with the inclusion of the internal mammary lymph nodes (IMNs). The effect of body mass index (BMI) on recorded dosimetric parameters was examined in the same patient cohort. METHODS AND MATERIALS: Fifty left-sided postmastectomy patients with breast cancer who underwent free-breathing (FB) and ABC-Elekta CT simulation scans were selected at random from an institutional breast cancer database between 2008 and 2014...
December 7, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28124561/%C3%AE-irradiation-effects-on-the-formation-and-stability-of-camoo4-in-a-soda-lime-borosilicate-glass-ceramic-for-nuclear-waste-storage
#7
Karishma B Patel, Bruno Boizot, Sébastien P Facq, Giulio I Lampronti, Sylvain Peuget, Sophie Schuller, Ian Farnan
Molybdenum solubility is a limiting factor to actinide loading in nuclear waste glasses, as it initiates the formation of water-soluble crystalline phases such as alkali molybdates. To increase waste loading efficiency, alternative glass ceramic structures are sought that prove resistant to internal radiation resulting from radioisotope decay. In this study, selective formation of water-durable CaMoO4 in a soda lime borosilicate is achieved by introducing up to 10 mol % MoO3 in a 1:1 ratio to CaO using a sintering process...
January 26, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28111907/seilacher-konstruktions-morphologie-morphodynamics-and-the-evolution-of-form
#8
Derek E G Briggs
Adolf Seilacher (1925-2014) was a German paleontologist who made the concept of Konstruktions-Morphologie (constructional morphology) his own, recognizing that organism morphology is not simply an adaptive response to selection pressure but incorporates phylogenetic and structural influences as well. He was particularly interested in "fabricational noise," nonadaptive features that are a consequence of available materials and modes of growth, but he also elucidated the nature of adaptive radiations-in bivalves and sand dollars, for example...
January 23, 2017: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/28078116/pretreatment-tumor-volume-as-a-prognostic-factor-in-metastatic-colorectal-cancer-treated-with-selective-internal-radiation-to-the-liver-using-yttrium-90-resin-microspheres
#9
Neha Bhooshan, Navesh K Sharma, Shahed Badiyan, Adeel Kaiser, Fred M Moeslein, Young Kwok, Pradip P Amin, Svetlana Kudryasheva, Michael D Chuong
BACKGROUND: Yttrium-90 ((90)Y)-resin microspheres can prolong intrahepatic disease control and improve overall survival (OS) in patients with metastatic colorectal cancer (CRC). Prognostic factors for improved outcomes in patients undergoing selective internal radiation therapy (SIRT) have been studied, but the relationship between pre-SIRT liver tumor volume and outcomes has not well described. METHODS: We retrospectively reviewed the records of patients with metastatic CRC who were treated at our institution with (90)Y-resin microspheres...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28074772/-nuclear-medicine-techniques-for-selective-internal-radiotherapy-of-liver-cancer
#10
Peter Frøhlich Staanum, Anne Kirstine Arveschoug, Stine Maria Jentoft Kramer, Jens Erik Nielsen, Dennis Tønner Nielsen, Peter Ott, Henning Grønbæk, Gerda Elisabeth Villadsen
Selective internal radiation therapy (SIRT) of hepatocellular carcinoma has been introduced at Aarhus University Hospital. 90Y-microspheres are implanted in the tumour by catheterization of the tumour feeding liver artery. Pretreatment angiography and test treatment using 99mTc-labelled particles followed by scintigraphy ensure a feasible and effective treatment. Post-treatment imaging of radiation from 90Y visualize the localization of microspheres. Currently, SIRT is also applied for liver metastases of neuroendocrine tumours...
January 2, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28066004/prevalence-of-psychiatric-morbidity-among-cancer-patients-hospital-based-cross-sectional-survey
#11
Mohan Roy Gopalan, Vidhukumar Karunakaran, Anil Prabhakaran, Krishnannair Lalithamma Jayakumar
AIM: To study the prevalence of Psychiatric disorders in cancer patients and to find out the factors associated with Psychiatric disorders in Cancer Patients. SETTINGS AND DESIGN: Department of Radiotherapy, Medical College, Thiruvananthapuram, cross sectional survey design was used. METHODS AND MATERIAL: Adult patients (18 years of age and above), having a diagnosis of carcinoma were selected by consecutive sampling method.A questionnaire which included back ground data, socio economic variables, treatment variables like type of malignancy, exposure to radiation & chemotherapy prior to the evaluation and current treatment, co occurring medical illness & treatment and past & family history of psychiatric illness was used to collect data...
July 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28048367/th-a-207b-00-shear-wave-imaging-and-a-qiba-us-biomarker-update
#12
Paul Carson
: Imaging of tissue elastic properties is a relatively new and powerful approach to one of the oldest and most important diagnostic tools. Imaging of shear wave speed with ultrasound is has been added to most high-end ultrasound systems. Understanding this exciting imaging mode aiding its most effective use in medicine can be a rewarding effort for medical physicists and other medical imaging and treatment professionals. Assuring consistent, quantitative measurements across the many ultrasound systems in a typical imaging department will constitute a major step toward realizing the great potential of this technique and other quantitative imaging...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048122/su-f-j-182-investigation-of-systems-for-improved-accuracy-in-clinical-y-90-percent-delivered-calculations
#13
R McBeth, D Elder, A Kesner
PURPOSE: Y-90 Selective Internal Radiation Therapy (SIRT) is used to treat liver tumors, and by nature has variability in the percent of the intended dose that is actually delivered. To determine the quality of the administration, pre and post activity measurements are taken, and used to infer percent delivered. Vendor specifications indicate the use of an ion chamber to take these measurements. In our work, we investigated the accuracy of ion chambers, and compared them to other detector systems...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047721/th-a-207b-01-basics-and-current-implementations-of-ultrasound-imaging-of-shear-wave-speed-and-elasticity
#14
S Chen
: Imaging of tissue elastic properties is a relatively new and powerful approach to one of the oldest and most important diagnostic tools. Imaging of shear wave speed with ultrasound is has been added to most high-end ultrasound systems. Understanding this exciting imaging mode aiding its most effective use in medicine can be a rewarding effort for medical physicists and other medical imaging and treatment professionals. Assuring consistent, quantitative measurements across the many ultrasound systems in a typical imaging department will constitute a major step toward realizing the great potential of this technique and other quantitative imaging...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047673/su-d-207a-06-pediatric-abdominal-organ-motion-quantified-via-a-novel-4d-mri-method
#15
J Uh, M J Krasin, J T Lucas, C Tinkle, T E Merchant, C Hua
PURPOSE: To develop a 4D MRI method for assessing respiration-induced abdominal organ motion in children receiving radiation therapy. METHODS: A 4D MRI using internal image-based respiratory surrogate has been developed and implemented on a clinical scanner (1.5T Siemens Avanto). Ten patients (younger group: N=6, 2-5 years, anesthetized; older group: N=4, 11-15 years) with neuroblastoma, Wilm's tumor rhabdomyosarcoma, or desmoplastic small round cell tumor received free breathing 4D MRI scans for treatment planning...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047072/th-a-207b-02-qiba-ultrasound-elasticity-imaging-system-biomarker-qualification-and-user-testing-of-systems
#16
B Garra
: Imaging of tissue elastic properties is a relatively new and powerful approach to one of the oldest and most important diagnostic tools. Imaging of shear wave speed with ultrasound is has been added to most high-end ultrasound systems. Understanding this exciting imaging mode aiding its most effective use in medicine can be a rewarding effort for medical physicists and other medical imaging and treatment professionals. Assuring consistent, quantitative measurements across the many ultrasound systems in a typical imaging department will constitute a major step toward realizing the great potential of this technique and other quantitative imaging...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046843/su-f-t-665-confocal-microscopy-imaging-of-cell-cycle-distribution-in-cells-treated-with-pegylated-gold-nanoshells
#17
D Sadetaporn, D Flint, C McFadden, A Asaithamby, G Sawakuchi
PURPOSE: To use confocal microscopy to distinguish cells in different phases of the cell cycle before and after treatment with pegylated gold nanoshells (PEG-AuNSs). METHODS: Transfected fibrosarcoma cells (HT1080-EYFP-53BP1-FUCCI) were cultured in T-25 flasks and seeded in glass bottom dishes. These cells express the fluorescent probe AmCyan during the G2/S phases of the cell cycle, mCherry during the G1 phase, and EYFP tagged to the DNA repair protein 53BP1. After allowing cells 4 h to adhere to dishes, PEG-AuNS (Nanospectra Biosciences, Houston, TX) at a concentration of 0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046479/we-ab-bra-05-pet-guided-delivery-quality-evaluation-of-yttrium-90-microsphere-radioembolizaton-for-hepatocellular-carcinoma-patients-the-optimal-sequence-of-radioembolizaton-and-chemoembolization-treatments
#18
M Lin, B Saboury
PURPOSE: Selective-internal-radiation-therapy (SIRT) and transarterial-chemoembolization (TACE) are commonly used for treatment of liver tumors. The use of TACE, which is macroembolic, prior to SIRT may cause hemodynamic changes in tumor vasculature that impair yttrium-90 (90Y) microsphere delivery to the targeted lesions. This work aims to quantify dosimetric tumor coverage using 90Y positron emission tomography (PET) dosimetry after SIRT alone compared to TACE followed by SIRT. METHODS: A total of 40 consecutive hepatocellular carcinoma (HCC) SIRT patients who had a post-SIRT 90Y PET/CT scan were evaluated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046457/su-f-t-355-evaluation-of-knowledge-based-planning-model-for-the-cervical-cancer-radiotherapy
#19
X Chen, J Wang, W Hu
PURPOSE: The Varian RapidPlan™ is a commercial knowledge-based optimization process which uses a set of clinically used treatment plans to train a model that can predict individualized dose-volume objectives. The purpose of this study is to evaluate the performance of RapidPlan to generate intensity modulated radiation therapy (IMRT) plans for cervical cancer. METHODS: Totally 70 IMRT plans for cervical cancer with varying clinical and physiological indications were enrolled in this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044260/summary-of-the-proceedings-of-the-international-forum-2016-imaging-referral-guidelines-and-clinical-decision-support-how-can-radiologists-implement-imaging-referral-guidelines-in-clinical-routine
#20
(no author information available yet)
: The International Forum is held once a year by the ESR and its international radiological partner societies with the aim to address and discuss selected subjects of global relevance in radiology. In 2016, the issue of implementing imaging referral guidelines in clinical routine was analysed. The legal environment in the USA requires that after January 1, 2017, physicians must consult government-approved, evidence-based appropriate-use criteria through a clinical decision support system when ordering advanced diagnostic imaging exams...
February 2017: Insights Into Imaging
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