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https://www.readbyqxmd.com/read/28346222/sign-determination-methods-for-the-respiratory-signal-in-data-driven-pet-gating
#1
Ottavia Bertolli, Simon Arridge, Scott D Wollenweber, Charles W Stearns, Brian F Hutton, Kris Thielemans
Patient respiratory motion during PET image acquisition leads to blurring in the reconstructed images and may cause significant artifacts, resulting in decreased lesion detectability, inaccurate standard uptake value calculation and incorrect treatment planning in radiation therapy. To reduce these effects data can be regrouped into (nearly) 'motion-free' gates prior to reconstruction by selecting the events with respect to the breathing phase. This gating procedure therefore needs a respiratory signal: on current scanners it is obtained from an external device, whereas with data driven (DD) methods it can be directly obtained from the raw PET data...
March 27, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28338865/assessment-of-public-exposure-form-wlans-in-the-west-bank-palestine
#2
Adnan Lahham, Afifeh Sharabati, Hussein ALMasri
A total of 271 measurements were conducted at 69 different sites including homes, hospitals, educational institutions and other public places to assess the exposure to radiofrequency emission from wireless local area networks (WLANs). Measurements were conducted at different distances from 40 to 10 m from the access points (APs) in real life conditions using Narda SRM-3000 selective radiation meter. Three measurements modes were considered at 1 m distance from the AP which are transmit mode, idle mode, and from the client card (laptop computer)...
March 3, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28336783/three-dimensional-dosimetry-for-radiation-safety-estimates-from-intrathecal-administration
#3
Jacob Hesterman, Susan Kost, Robert Holt, Howard Dobson, Ajay Verma, P David Mozley
Intrathecal (IT) administration is of growing interest for drug delivery and its utility is being increasingly investigated through imaging. In this work, the three-dimensional (3D) Voxel-Based Internal Dosimetry Application (VIDA) and 4D Extended Cardiac Torso Phantom (XCAT) were extended to provide radiation safety estimates specific to intrathecal administration. Methods: The 3D VIDA dosimetry application Monte Carlo simulation was run using a modified XCAT phantom with additional and edited cerebrospinal fluid (CSF) regions to produce voxel-level absorbed dose per unit cumulated activity maps for nine selected source regions...
March 23, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28336780/biodistribution-and-radiation-dosimetry-for-the-tau-tracer-18-f-thk-5351-in-healthy-human-subjects
#4
Ing-Tsung Hsiao, Kun-Ju Lin, Kuo-Lun Huang, Chin-Chang Huang, Han-Shiuan Chen, Shiaw-Pyng Wey, Tzu-Chen Yen, Nobuyuki Okamura, Jung-Lung Hsu
(18)F-THK-5351 is a novel radiotracer that demonstrates high binding selectivity and affinity for tau pathology and exhibits better pharmacokinetics in the living brain than previous THK tau probes. The aim of the present study was to estimate the radiation dose of (18)F-THK-5351 in humans and to compare the clinical radiation dosimetry results to estimations published previously with preclinical data. Methods: Serial whole-body positron emission tomography/computed tomography (PET/CT) imaging was performed for 240 min on 12 healthy volunteers after injecting (18)F-THK-5351 (mean administered activity: 377...
March 23, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28291159/67cu-radiolabeling-of-a-multimeric-rgd-peptide-for-%C3%AE-v%C3%AE-3-integrin-targeted-radionuclide-therapy-stability-therapeutic-efficacy-and-safety-studies-in-mice
#5
Zhao-Hui Jin, Takako Furukawa, Tomoyuki Ohya, Mélissa Degardin, Aya Sugyo, Atsushi B Tsuji, Yasuhisa Fujibayashi, Ming-Rong Zhang, Tatsuya Higashi, Didier Boturyn, Pascal Dumy, Tsuneo Saga
OBJECTIVE: Copper-67 (Cu) is one of the most promising radionuclides for internal radiation therapy. Globally, several projects have recently been initiated for developing innovative approaches for the large-scale production of Cu. Encouraged by these, we performed Cu-radiolabeling of a tetrameric cyclic Arg-Gly-Asp (cRGD) peptide conjugate, cyclam-RAFT-c(-RGDfK-)4, which selectively targets αVβ3 integrin (αVβ3), the transmembrane receptor involved in tumor invasion, angiogenesis, and metastasis...
April 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28260960/clinical-hematological-and-cytogenetic-profile-of-adult-myelodysplastic-syndrome-in-a-tertiary-care-center
#6
Santhosh Narayanan
BACKGROUND: Myelodysplastic syndrome (MDS), a disorder of clonal hematopoiesis, is an important clinical entity, but most of the studies available are conducted among the Western population. Its etiological factors and clinicohematological profile in the Indian population are quite diverse. The information regarding its prognostic factors and cytogenetics is very scarce. OBJECTIVES: (1) To assess the clinicohematological profile, cytogenetics, prognostic factors, and outcome of MDS and (2) to study its progression to acute myeloid leukemia (AML) in the selected patients over the study period...
2017: Journal of Blood Medicine
https://www.readbyqxmd.com/read/28257069/a-technical-approach-to-the-evaluation-of-radiofrequency-radiation-emissions-from-mobile-telephony-base-stations
#7
Raimondas Buckus, Birute Strukčinskienė, Juozas Raistenskis, Rimantas Stukas, Aurelija Šidlauskienė, Rimantė Čerkauskienė, Dorina Nicolina Isopescu, Jan Stabryla, Igor Cretescu
During the last two decades, the number of macrocell mobile telephony base station antennas emitting radiofrequency (RF) electromagnetic radiation (EMR) in residential areas has increased significantly, and therefore much more attention is being paid to RF EMR and its effects on human health. Scientific field measurements of public exposure to RF EMR (specifically to radio frequency radiation) from macrocell mobile telephony base station antennas and RF electromagnetic field (EMF) intensity parameters in the environment are discussed in this article...
March 1, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28255386/variation-in-uterus-position-prior-to-brachytherapy-of-the-cervix-a-case-report
#8
M T Georgescu, R Anghel
Rationale: brachytherapy is administered in the treatment of patients with locally advanced cervical cancer following chemoradiotherapy. Lack of local anatomy evaluation prior to this procedure might lead to the selection of an inappropriate brachytherapy applicator, increasing the risk of side effects (e.g. uterus perforation, painful procedure ...). Objective: To assess the movement of the uterus and cervix prior to brachytherapy in patients with gynecological cancer, in order to select the proper type of brachytherapy applicator...
January 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/28242163/adjuvant-radiotherapy-use-by-us-radiation-oncologists-after-radical-cystectomy-for-muscle-invasive-bladder-cancer
#9
A A Solanki, B Martin, M Korpics, C Small, M M Harkenrider, T Mitin
AIMS: Historic trials suggested significant toxicity with adjuvant radiotherapy (ART) after radical cystectomy for muscle-invasive bladder cancer (MIBC). However, recent trials have found improved locoregional control and the 2016 National Comprehensive Cancer Network (NCCN) guidelines recommend ART consideration for select patients at high risk of local recurrence. ART practice patterns among US radiation oncologists are unknown and we carried out a survey to explore current trends. MATERIALS AND METHODS: We conducted a survey of US radiation oncologists regarding the management of patients with cT2-3N0M0 transitional cell MIBC...
February 24, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28237869/the-role-of-image-guided-therapy-in-the-management-of-colorectal-cancer-metastatic-disease
#10
REVIEW
Thierry de Baere, Lambros Tselikas, Steven Yevich, Valérie Boige, Frederic Deschamps, Michel Ducreux, Diane Goere, France Nguyen, David Malka
The European Society for Medical Oncology (ESMO) have stressed that the option for treating oligometastatic disease is a strategy of local ablative therapy, the goal of which is to improve disease control. The spectrum of the local ablative therapy toolbox described by the ESMO includes surgical R0 resection, percutaneous ablation and intra-arterial therapies, the choice of treatment being left to the multidisciplinary team. Interventional therapy involving image-guided treatment offers the possibility of less invasive treatments for colorectal cancer metastases in the liver, lung and bone by preserving from toxicity distant healthy organs or even parts of the diseased organs...
February 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28237401/unraveling-biophysical-interactions-of-radiation-pneumonitis-in-non-small-cell-lung-cancer-via-bayesian-network-analysis
#11
Yi Luo, Issam El Naqa, Daniel L McShan, Dipankar Ray, Ines Lohse, Martha M Matuszak, Dawn Owen, Shruti Jolly, Theodore S Lawrence, Feng-Ming Spring Kong, Randall K Ten Haken
BACKGROUND: In non-small-cell lung cancer radiotherapy, radiation pneumonitis≥grade 2 (RP2) depends on patients' dosimetric, clinical, biological and genomic characteristics. METHODS: We developed a Bayesian network (BN) approach to explore its potential for interpreting biophysical signaling pathways influencing RP2 from a heterogeneous dataset including single nucleotide polymorphisms, micro RNAs, cytokines, clinical data, and radiation treatment plans before and during the course of radiotherapy...
February 22, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28236539/individual-case-review-in-a-phase-3-randomized-trial-to-investigate-the-role-of-internal-mammary-lymph-node-irradiation-for-breast-cancer-korean-radiation-oncology-group-08-06-study
#12
Hong In Yoon, Jeongmin Yoon, Yoonsun Chung, Chung Mo Nam, Hyejung Cha, Jinhyun Choi, Jeongshim Lee, Hee Ji Han, Yeona Cho, Yong Bae Kim, Chang-Ok Suh
PURPOSE/OBJECTIVE: This study aimed to assess protocol compliance based on an individual case review (ICR) of the Korean Radiation Oncology Group-0806 trial. METHODS AND MATERIALS: For the ICR, 747 participants were divided into eight subgroups based on internal mammary node irradiation (IMNI), tumor laterality, and surgery type. Next, 15% of patients were randomly selected within each subgroup, and corresponding hospitals were subsequently requested to upload information related to radiation therapy (RT) planning...
February 21, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28213624/oligometastatic-colorectal-cancer-is-single-site-bony-colorectal-metastasis-a-treatable-condition
#13
Noel Cassar, Adrian Ben Cresswell, Brendan Moran
INTRODUCTION: A potentially resectable bony metastasis in the context of oligometastatic colorectal cancer is uncommon. Bony metastases are usually considered a late event with poor prognosis and generally associated with liver and/or lung metastases. INDEX CASE: A previously healthy 33-year-old gentleman, with no family history of colorectal cancer, presented with rectal bleeding and at colonoscopy had a biopsy-proven adenocarcinoma of the rectum, 7 cm from the anal verge...
February 17, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28202430/vespro-an-individual-patient-data-prospective-meta-analysis-of-selective-internal-radiation-therapy-versus-sorafenib-for-advanced-locally-advanced-or-recurrent-hepatocellular-carcinoma-of-the-sarah-and-sirvenib-trials
#14
Val Gebski, Emma Gibbs, Mihir Gandhi, Gilles Chatellier, Aurelia Dinut, Helena Pereira, Pierce Kh Chow, Valérie Vilgrain
BACKGROUND: Untreated advanced hepatocellular carcinoma (HCC) has an overall poor prognosis. Currently there are 2 ongoing prospective randomized controlled trials that are evaluating the efficacy and safety of sorafenib and selective internal radiation therapy (SIRT) with yttrium-90 resin microspheres in patients with advanced HCC. The SorAfenib versus Radioembolisation in Advanced Hepatocellular carcinoma (SARAH; 459 patients) trial is being performed in Europe and the SIRt VErsus SorafeNIB (SIRveNIB; 360 patients) trial in the Asia Pacific region...
February 15, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28190843/application-of-internal-standard-method-for-several-3d-transition-metallic-elements-in-flame-atomic-absorption-spectrometry-using-a-multi-wavelength-high-resolution-spectrometer
#15
Yusuke Toya, Toshiko Itagaki, Kazuaki Wagatsuma
We investigated a simultaneous internal standard method in flame atomic absorption spectrometry (FAAS), in order to better the analytical precision of 3d-transition metals contained in steel materials. For this purpose, a new spectrometer system for FAAS, comprising a bright xenon lamp as the primary radiation source and a high-resolution Echelle monochromator, was employed to measure several absorption lines at a wavelength width of ca. 0.3 nm at the same time, which enables the absorbances of an analytical line and also an internal standard line to be estimated...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28177190/improving-patient-selection-for-selective-internal-radiation-therapy-of-intra-hepatic-cholangiocarcinoma-a-meta-regression-study
#16
Alessandro Cucchetti, Alberta Cappelli, Cristina Mosconi, Jian-Hong Zhong, Matteo Cescon, Antonio Daniele Pinna, Rita Golfieri
BACKGROUND & AIMS: Selective Internal Radiation Therapy (SIRT) is emerging as a potential therapy for unresectable intra-hepatic cholangiocarcinoma (iCCA), able to prolong life-expectancy. Aim of the study was to collect available literature, meta-analyze data and results and investigate sources of heterogeneity through a meta-regression approach, before suggesting SIRT as a valuable option. METHODS: A systematic review of studies published until 1 September 2016 in PubMed and Scopus databases was performed...
February 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28164066/giant-cell-tumor-developing-in-paget-s-disease-of-bone-a-case-report-with-review-of-literature
#17
Vivek Verma, Ajay Puri, Sanket Shah, Bharat Rekhi, Ashish Gulia
INTRODUCTION: Paget's disease of bone (PDB) is a disease of elderly characterized by disorganized bone remodeling. Development of secondary neoplasm in PDB is a known but rare phenomenon. Development of giant cell tumor in PDB (GCT-PDB) is extremely rare, and little is known about its etiopathogenesis and management. We present a case report of such a development with a review of the literature and the role of various new modalities of treatment available in the management of this rare condition...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28139424/the-impact-of-active-breathing-control-on-internal-mammary-lymph-node-coverage-and-normal-tissue-exposure-in-breast-cancer-patients-planned-for-left-sided-postmastectomy-radiation-therapy
#18
Aisling Barry, Kathy Rock, Claudio Sole, Mohammad Rahman, Melania Pintilie, Grace Lee, Anthony Fyles, C Anne Koch
PURPOSE: The purpose of this study was to evaluate the impact of the active breathing control (ABC) technique on IMN coverage and organs at risk in patients planned for postmastectomy radiation therapy (PMRT), with the inclusion of the internal mammary lymph nodes (IMNs). The effect of body mass index (BMI) on recorded dosimetric parameters was examined in the same patient cohort. METHODS AND MATERIALS: Fifty left-sided postmastectomy patients with breast cancer who underwent free-breathing (FB) and ABC-Elekta CT simulation scans were selected at random from an institutional breast cancer database between 2008 and 2014...
December 7, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28124561/%C3%AE-irradiation-effects-on-the-formation-and-stability-of-camoo4-in-a-soda-lime-borosilicate-glass-ceramic-for-nuclear-waste-storage
#19
Karishma B Patel, Bruno Boizot, Sébastien P Facq, Giulio I Lampronti, Sylvain Peuget, Sophie Schuller, Ian Farnan
Molybdenum solubility is a limiting factor to actinide loading in nuclear waste glasses, as it initiates the formation of water-soluble crystalline phases such as alkali molybdates. To increase waste loading efficiency, alternative glass ceramic structures are sought that prove resistant to internal radiation resulting from radioisotope decay. In this study, selective formation of water-durable CaMoO4 in a soda lime borosilicate is achieved by introducing up to 10 mol % MoO3 in a 1:1 ratio to CaO using a sintering process...
January 26, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28111907/seilacher-konstruktions-morphologie-morphodynamics-and-the-evolution-of-form
#20
Derek E G Briggs
Adolf Seilacher (1925-2014) was a German paleontologist who made the concept of Konstruktions-Morphologie (constructional morphology) his own, recognizing that organism morphology is not simply an adaptive response to selection pressure but incorporates phylogenetic and structural influences as well. He was particularly interested in "fabricational noise," nonadaptive features that are a consequence of available materials and modes of growth, but he also elucidated the nature of adaptive radiations-in bivalves and sand dollars, for example...
January 23, 2017: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
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