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https://www.readbyqxmd.com/read/29140684/janus-gold-nanoplatform-for-synergetic-chemoradiotherapy-and-computed-tomography-imaging-of-hepatocellular-carcinoma
#1
Zheng Wang, Dan Shao, Zhimin Chang, Mengmeng Lu, Yingshuai Wang, Juan Yue, Dian Yang, Mingqiang Li, Qiaobing Xu, Wen-Fei Dong
There is a pressing need to develop nanoplatforms that integrate multimodal therapeutics to improve treatment responses and prolong the survival of patients with unresectable hepatocellular carcinoma (HCC). Mesoporous silica-coated gold nanomaterials have emerged as a novel multifunctional platform combining tunable surface plasmon resonance and mesoporous properties that exhibit multimodality properties in cancer theranostics. However, their reduced radiation-absorption efficiency and limited surface area hinder their further radiochemotherapeutic applications...
November 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/29113650/laparoscopic-parenchymal-preserving-liver-resections-for-colorectal-liver-metastases-in-the-era-of-highly-effective-systemic-therapy-and-selective-internal-radiation-therapy-can-often-prevent-a-hemihepatectomy-with-video
#2
Mathieu D'Hondt, Frédéric Ververken, Frederiek Nuytens
BACKGROUND: Preservation of hepatic parenchyma is important in liver surgery to prevent postoperative liver failure and according to some reports it could offer a prolonged survival and lower recurrence rates compared to major hepatectomies in patients with colorectal liver metastases. However, laparoscopic parenchyma-preserving liver resections can be technically challenging. The aim of this video is to illustrate the concept of laparoscopic parenchymal-preserving liver resections after conversion chemotherapy with targeted therapy...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113030/recent-advances-in-transarterial-embolotherapies-in-the-treatment-of-hepatocellular-carcinoma
#3
Edward Wolfgang Lee, Sarah Khan
Management of hepatocellular carcinoma (HCC) can be maximized with the utilization of multiple treatment modalities including transplant, surgical resection and locoregional therapies including ablative therapies and transarterial embolotherapies. Although transplant and surgical resection offer the best clinical outcomes, a limited number of patients are amenable to these surgical treatment options due to the advanced disease at presentation. Transarterial embolotherapies including conventional transarterial chemoembolization (cTACE), bland transarterial embolization (TAE), drug-eluting beads transarterial chemoembolization (DEB-TACE) and selective internal radiation therapy (SIRT) with Yttrium 90 (90Y) have played an increasingly important role for these patients with unresectable HCC...
November 8, 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29105051/tumour-bed-boost-radiotherapy-for-women-after-breast-conserving-surgery
#4
REVIEW
Isabelle Kindts, Annouschka Laenen, Tom Depuydt, Caroline Weltens
BACKGROUND: Breast-conserving therapy, involving breast-conserving surgery followed by whole-breast irradiation and optionally a boost to the tumour bed, is a standard therapeutic option for women with early-stage breast cancer. A boost to the tumour bed means that an extra dose of radiation is applied that covers the initial tumour site. The rationale for a boost of radiotherapy to the tumour bed is that (i) local recurrence occurs mostly at the site of the primary tumour because remaining microscopic tumour cells are most likely situated there; and (ii) radiation can eliminate these causative microscopic tumour cells...
November 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29101605/cholesterol-homeostasis-and-cell-proliferation-by-mitogenic-homologs-insulin-benzo-%C3%AE-pyrene-and-uv-radiation
#5
Hemlata Pandey, Ayantika Talukdar, Jeremy S Gangte, S Datta Gupta, N C Chandra
Low-Density Lipoprotein (LDL) is known to promote the unregulated proliferation of cells that is progression of cancer. We aimed to investigate the effect of mitogens on the expression of cell cycle proteins, nuclear cholesterol and cell proliferation. We observed that insulin and benzo-α-pyrene (BaP) induced the expression of Low-Density Lipoprotein receptor (LDLR) on HepG2 cells, thereby enhancing the uptake of LDL. The internalized LDL increased the concentration of cholesterol in the cytoplasm and nucleus of the cell...
November 3, 2017: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/29098563/melanization-affects-the-content-of-selected-elements-in-parmelioid-lichens
#6
Lorenzo Fortuna, Elena Baracchini, Gianpiero Adami, Mauro Tretiach
Lichens belonging to Parmeliaceae are highly diversified, but most of them share an extremely conserved morpho-chemical trait: the lower cortex is heavily melanized. The adaptive value of this character is still uncertain. Melanins are ubiquitous compounds found in most organisms since they fulfil several biological functions including defense against UV radiation, oxidizing agents, microbial stress, and metal complexation. This work aims to establish whether melanization can affect the elemental content of lichen thalli...
November 3, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/29095187/defining-the-role-of-free-flaps-for-transoral-robotic-surgery
#7
Kyle M Hatten, Robert M Brody, Gregory S Weinstein, Jason G Newman, Andres M Bur, Ara A Chalian, Bert W OʼMalley, Christopher H Rassekh, Steven B Cannady
BACKGROUND: Transoral surgical techniques for oropharyngeal tumors have been widely accepted, yet often results in a significant functional deficit. Current reports on the safety, feasibility, and swallowing performance after microvascular reconstruction are limited to small volume case series. MATERIALS AND METHODS: Retrospective review of 42 consecutive patients, between December 2013 and May 2016, who underwent transoral robotic surgery oropharyngectomy followed by microvascular reconstruction...
October 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29090358/predictive-sirt-dosimetry-based-on-a-territorial-model
#8
Nadine Spahr, Philipp Schilling, Smita Thoduka, Nasreddin Abolmaali, Andrea Schenk
BACKGROUND: In the planning of selective internal radiation therapy (SIRT) for liver cancer treatment, one major aspect is to determine the prescribed activity and to estimate the resulting absorbed dose inside normal liver and tumor tissue. An optimized partition model for SIRT dosimetry based on arterial liver territories is proposed. This model is dedicated to characterize the variability of dose within the whole liver. For an arbitrary partition, the generalized absorbed dose is derived from the classical partition model...
October 31, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/29063851/development-and-internal-validation-of-a-clinical-risk-score-to-predict-pain-response-after-palliative-radiation-therapy-in-patients-with-bone-metastases
#9
Joanne M van der Velden, Max Peters, Jorrit-Jan Verlaan, Anne L Versteeg, Liying Zhang, May Tsao, Cyril Danjoux, Elizabeth Barnes, Marco van Vulpen, Edward Chow, Helena M Verkooijen
PURPOSE: To investigate the relationship between patient and tumor characteristics and pain response in patients with metastatic bone disease, and construct and internally validate a clinical prediction model for pain response to guide individualized treatment decision making. MATERIAL AND METHODS: A total of 965 patients with painful bone metastases undergoing palliative radiation therapy at a tertiary referral center between 1999 and 2007 were identified. Pain scores were measured at 1, 2, and 3 months after radiation therapy...
November 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29054450/a-portable-precision-ionization-chamber-the-transfer-ionization-reference-chamber
#10
Frédéric Juget, Youcef Nedjadi, Thierry Buchillier, Teresa Durán, François Bochud, Christian Kottler, Claude Bailat
A portable instrument was developed at the Institute of Radiation Physics (IRA) for on-site radionuclides measurements. It will enable the measurement of short-lived radionuclides in nuclear medicine departments or isotope production centres. The system involves an ionization chamber read directly by an electrometer and it was optimized to ensure a good reproducibility through the selection of an appropriate vial, filling volume and source position in the well chamber, as well as monitoring the external background and performing a detailed uncertainty estimation...
October 12, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29042472/technical-advances-in-image-guidance-of-radionuclide-therapy
#11
Casper Beijst, Britt Kunnen, Marnix Lam, Hugo de Jong
Internal radiation therapy with radionuclides (i.e. radionuclide therapy) owes its success to the many advantages over other, more conventional treatment options. One distinct advantage of radionuclide therapies is the potential to use (part of) the emitted radiation for imaging of the radionuclide distribution. The combination of diagnostic and therapeutic properties in a set of matched radiopharmaceuticals (sometimes combined in single a radiopharmaceutical) is often referred to as theranostics and allows accurate diagnostic imaging prior to therapy...
October 17, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29032802/radioembolisation-of-hepatocellular-carcinoma-a-primer
#12
REVIEW
N Venkatanarasimha, A Gogna, K T A Tong, K Damodharan, P K H Chow, R H G Lo, S Chandramohan
Transarterial radioembolisation (TARE) has gained increasing acceptance as an additional/alternative locoregional treatment option for hepatocellular carcinoma, and colorectal hepatic metastases that present beyond potentially curative options. This is a catheter-based transarterial selective internal brachytherapy that involves injection of radioactive microspheres (usually Y-90) that are delivered selectively to the liver tumours. Owing to the combined radioactive and microembolic effect, the findings at follow-up imaging are significantly different from that seen with other transarterial treatment options...
October 9, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29030462/selective-ophthalmic-artery-chemosurgery-soac-for-retinoblastoma-fluoroscopic-time-and-radiation-dose-parameters-a-baseline-study
#13
Srikanth R Boddu, David H Abramson, Brian P Marr, Jasmine H Francis, Y Pierre Gobin
OBJECTIVE: To evaluate fluoroscopic time and radiation dose parameters, and factors affecting these parameters, during selective ophthalmic artery chemosurgery (SOAC) for retinoblastoma. MATERIALS AND METHODS: Retrospective review from the prospective database of all patients with retinoblastoma treated with SOAC over a 5-year period (September 2009-January 2015) at a single institution after receiving institutional review board approval. Patient demographics, arterial approach, access device, side of treatment, number of SOAC cycles/patient, number of drugs/SOAC, and radiation parameters (outcome variables), including the fluoroscopic time, dose-area product (DAP), and total radiation dose, were obtained from the database...
November 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28994576/combined-computed-nanotomography-and-nanoscopic-x-ray-fluorescence-imaging-of-cobalt-nanoparticles-in-caenorhabditis-elegans
#14
Simone Cagno, Dag Anders Brede, Gert Nuyts, Frederik Vanmeert, Alexandra Pacureanu, Remi Tucoulou, Peter Cloetens, Gerald Falkenberg, Koen Janssens, Brit Salbu, Ole Christian Lind
Synchrotron radiation phase-contrast computed nanotomography (nano-CT) and two- and three-dimensional (2D and 3D) nanoscopic X-ray fluorescence (nano-XRF) were used to investigate the internal distribution of engineered cobalt nanoparticles (Co NPs) in exposed individuals of the nematode Caenorhabditis elegans. Whole nematodes and selected tissues and organs were 3D-rendered: anatomical 3D renderings with 50 nm voxel size enabled the visualization of spherical nanoparticle aggregates with size up to 200 nm within intact C...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28990929/multiparametric-magnetic-resonance-imaging-for-active-surveillance-of-prostate-cancer
#15
Julie Y An, Abhinav Sidana, Peter L Choyke, Bradford Wood, Peter A Pinto, İsmail Barış Türkbey
Active surveillance has gained popularity as an acceptable management option for men with low-risk prostate cancer. Successful utilization of this strategy can delay or prevent unnecessary interventions - thereby reducing morbidity associated with overtreatment. The usefulness of active surveillance primarily depends on correct identification of patients with low-risk disease. However, current population-wide algorithms and tools do not adequately exclude high-risk disease, thereby limiting the confidence of clinicians and patients to go on active surveillance...
September 29, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28982361/distribution-of-plga-modified-nanoparticles-in-3d-cell-culture-models-of-hypo-vascularized-tumor-tissue
#16
Lee B Sims, Maya K Huss, Hermann B Frieboes, Jill M Steinbach-Rankins
BACKGROUND: Advanced stage cancer treatments are often invasive and painful-typically comprised of surgery, chemotherapy, and/or radiation treatment. Low transport efficiency during systemic chemotherapy may require high chemotherapeutic doses to effectively target cancerous tissue, resulting in systemic toxicity. Nanotherapeutic platforms have been proposed as an alternative to more safely and effectively deliver therapeutic agents directly to tumor sites. However, cellular internalization and tumor penetration are often diametrically opposed, with limited access to tumor regions distal from vasculature, due to irregular tissue morphologies...
October 5, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28981883/radon-concentration-in-the-area-of-waste-rock-dumps-brod-cr-case-study
#17
L Thinova, R Bican, A Fronka, K Johnova, J Solc, J Vosahlik
There are ~7000 mining waste storage facilities including waste rock dumps in the Czech Republic. One of the radiation protection present subjects is a health impact estimation of the huge mass of material in waste rock dumps left after uranium mining. In this document are presented selected results of waste rock dump long-term monitoring in the area of shaft No. 15 (Pribram, CR) and its estimated health impact to the representative person in a village Brod. The external irradiation was estimated based on in situ gamma spectrometry measurement results and on a Monte Carlo model and it turned out to be negligible (tens μSv), while the internal irradiation (RAMARN, ALGADE Environmental and RAMONIS detection systems) is more significant...
September 15, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28975561/liver-transarterial-embolizations-in-metastatic-neuroendocrine-tumors
#18
REVIEW
Louis de Mestier, Magaly Zappa, Olivia Hentic, Valérie Vilgrain, Philippe Ruszniewski
The management of patients with well-differentiated neuroendocrine tumors (NET) and non-resectable liver metastases is challenging. Liver-directed transarterial embolization (TAE), transarterial chemo-embolization (TACE) and selective internal radiation therapy (SIRT) have a place of choice among other treatment modalities. However, their utilization relies on a low level of proof, due to the lack of prospective data, the absence of comparative studies and considerable heterogeneity between local practices...
October 3, 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28974597/selective-internal-radiation-therapy-for-liver-tumours
#19
Francis X Sundram, John R Buscombe
Primary and secondary liver malignancies are common and associated with a poor prognosis. Surgical resection is the treatment of choice; however, many patients have unresectable disease. In these cases, several liver directed therapies are available, including selective internal radiation therapy (SIRT). SIRT is a multidisciplinary treatment involving nuclear medicine, interventional radiology and oncology. High doses of localised internal radiation are selectively delivered to liver tumour tissues, with relative sparing of adjacent normal liver parenchyma...
October 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28951007/-18-f-fdg-pet-image-biomarkers-improve-prediction-of-late-radiation-induced-xerostomia
#20
Lisanne V van Dijk, Walter Noordzij, Charlotte L Brouwer, Ronald Boellaard, Johannes G M Burgerhof, Johannes A Langendijk, Nanna M Sijtsema, Roel J H M Steenbakkers
BACKGROUND AND PURPOSE: Current prediction of radiation-induced xerostomia 12months after radiotherapy (Xer12m) is based on mean parotid gland dose and baseline xerostomia (Xerbaseline) scores. The hypothesis of this study was that prediction of Xer12m is improved with patient-specific characteristics extracted from (18)F-FDG PET images, quantified in PET image biomarkers (PET-IBMs). PATIENTS AND METHODS: Intensity and textural PET-IBMs of the parotid gland were collected from pre-treatment (18)F-FDG PET images of 161 head and neck cancer patients...
September 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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